{ "directed": true, "multigraph": false, "graph": {}, "nodes": [ { "id": "reaction_10315596", "map_id": "none", "name": "KIR3DL2 interacting with HLA-A3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q2V3", "map_id": "A0A6I8Q2V3", "name": "Ig lambda chain V region 4A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RZZ7", "map_id": "A0A6I8RZZ7", "name": "Ig lambda chain V region 4A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SEP6", "map_id": "A0A6I8SEP6", "name": "Ig lambda chain V region 4A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QNA7", "map_id": "A0A6I8QNA7", "name": "Ig lambda chain V region 4A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", 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"type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RFV0", "map_id": "A0A6I8RFV0", "name": "A0A6I8RFV0", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035252", "map_id": "ENSXETG00000035252", "name": "A0A6I8RFV0", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q3Z3", "map_id": "A0A6I8Q3Z3", "name": "A0A6I8Q3Z3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039491", "map_id": "ENSXETG00000039491", "name": "A0A6I8Q3Z3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QXJ1", "map_id": "A0A6I8QXJ1", 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region ARH-77", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RGY2", "map_id": "A0A6I8RGY2", "name": "Ig heavy chain V-II region ARH-77", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8STT9", "map_id": "A0A6I8STT9", "name": "Ig heavy chain V-II region ARH-77", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RG22", "map_id": "A0A6I8RG22", "name": "Ig heavy chain V-II region ARH-77", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SK71", "map_id": "A0A6I8SK71", "name": "Ig heavy chain V-II region ARH-77", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QZL1", "map_id": "A0A6I8QZL1", "name": "Ig heavy chain V-II region ARH-77", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RUJ4", "map_id": "A0A6I8RUJ4", "name": "Ig heavy chain V-II region ARH-77", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QKP4", "map_id": "A0A6I8QKP4", "name": "Ig heavy chain V-II region ARH-77", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RNX1", "map_id": "A0A6I8RNX1", "name": "Ig heavy chain V-II region ARH-77", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10315562", "map_id": "none", "name": "CD40LG trimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F6WJ69", "map_id": "F6WJ69", "name": "ltb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000005335", "map_id": "ENSXETT00000005335", "name": "ltb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PXA6", "map_id": "A0A6I8PXA6", "name": "tnfsf10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000030595", "map_id": "ENSXETG00000030595", "name": "tnfsf10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10315566", "map_id": "none", "name": "CD40 trimer", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10315568", "map_id": "none", "name": "CD40:CD40L trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10313549", "map_id": "none", "name": "COMT transfer CH3 from AdoMet to 3,4DHBNZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_175977", "map_id": "CHEBI:36062", "name": "3,4DHBNZ", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_71284", "map_id": "CHEBI:15414", "name": "AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_175978", "map_id": "CHEBI:63797", "name": "3H,4MBNZ", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_71285", "map_id": "CHEBI:16680", "name": "AdoHcy", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10313546", "map_id": "A9UMU1", "name": "LOC100135405", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000064849", "map_id": "ENSXETT00000064849", "name": "LOC100135405", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10313556", "map_id": "none", "name": "NNMT transfers CH3 from AdoMet to PY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_175973", "map_id": "CHEBI:16227", "name": "PY", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_175979", "map_id": "CHEBI:15761", "name": "MP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10313553", "map_id": "A0A6I8PN79", "name": "nnmt", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000028049", "map_id": "ENSXETG00000028049", "name": "nnmt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329809", "map_id": "none", "name": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29356", "map_id": "CHEBI:15377", "name": "H2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113592", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_174390", "map_id": "CHEBI:57844", "name": "L-Met", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111294", "map_id": "CHEBI:29888", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29372", "map_id": "CHEBI:43474", "name": "Pi", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10329806", "map_id": "none", "name": "MAT2B:MAT2A:K+:2Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_109496", "map_id": "CHEBI:18420", "name": "Mg2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "F6X2C1", "map_id": "F6X2C1", "name": "wasll", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000002716", "map_id": "ENSXETT00000002716", "name": "wasll", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_74126", "map_id": "CHEBI:29103", "name": "K+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "Q566L8", "map_id": "Q566L8", "name": "mat2b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000015071", "map_id": "ENSXETG00000015071", "name": "mat2b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312209", "map_id": "none", "name": "CYP1A2 S-demethylates 6MMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_113534", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_156540", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76384", "map_id": "CHEBI:28279", "name": "6MMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113601", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_143501", "map_id": "CHEBI:16842", "name": "CH2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113519", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113564", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_33153", "map_id": "CHEBI:2208", "name": "6MP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10312204", "map_id": "A4IGV4", "name": "cyp1a1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETT00000061279", "map_id": "ENSXETT00000061279", "name": "cyp1a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10331414", "map_id": "none", "name": "ABHD10 hydrolyses MPAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5694574", "map_id": "CHEBI:64689", "name": "AMPAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113521", "map_id": "CHEBI:15377", "name": "H2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5694569", "map_id": "CHEBI:15748", "name": "GlcA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5694565", "map_id": "CHEBI:168396", "name": "MPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10331411", "map_id": "F7EUE5", "name": "abhd10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "ENSXETT00000020196", "map_id": "ENSXETT00000020196", "name": "abhd10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10313610", "map_id": "none", "name": "GST trimers transfer GS from GSH to luminal substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_158543", "map_id": "CHEBI:16856", "name": "GSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_176065", "map_id": "none", "name": "electrophilic substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_156523", "map_id": "CHEBI:30725", "name": "AFXBO", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_38987", "map_id": "CHEBI:27561", "name": "EtO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76396", "map_id": "CHEBI:29132", "name": "NABQI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_176048", "map_id": "none", "name": "electrophilic substrate:SG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:32639", "map_id": "CHEBI:32639", "name": "CHEBI:32639", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:2505", "map_id": "CHEBI:2505", "name": "CHEBI:2505", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:35896", "map_id": "CHEBI:35896", "name": "CHEBI:35896", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10313607", "map_id": "none", "name": "MGST trimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A6I8RJ83", "map_id": "A0A6I8RJ83", "name": "mgst2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036671", "map_id": "ENSXETG00000036671", "name": "mgst2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6PX96", "map_id": "F6PX96", "name": "mgst1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000016673", "map_id": "ENSXETT00000016673", "name": "mgst1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6VC96", "map_id": "F6VC96", "name": "mgst3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000010309", "map_id": "ENSXETT00000010309", "name": "mgst3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10331194", "map_id": "none", "name": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29366", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692212", "map_id": "CHEBI:81626", "name": "BaPtDHD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692216", "map_id": "CHEBI:87752", "name": "BaP-7,8-dione", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29364", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10330359", "map_id": "Q28FD1", "name": "akr1a1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000007570", "map_id": "ENSXETT00000007570", "name": "akr1a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10322294", "map_id": "none", "name": "GGCT transforms gGluCys to OPRO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174393", "map_id": "CHEBI:17515", "name": "gGluCys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111707", "map_id": "CHEBI:35235", "name": "L-Cys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1247942", "map_id": "CHEBI:18183", "name": "OPRO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10322291", "map_id": "none", "name": "GGCT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F6PKI1", "map_id": "F6PKI1", "name": "ggct", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000047646", "map_id": "ENSXETT00000047646", "name": "ggct", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10313587", "map_id": "none", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29450", "map_id": "CHEBI:16856", "name": "GSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176070", "map_id": "none", "name": "Electrophilic substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:34718", "map_id": "CHEBI:34718", "name": "CHEBI:34718", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:30614", "map_id": "CHEBI:30614", "name": "CHEBI:30614", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_176049", "map_id": "none", "name": "electrophilic substrate:SG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:8927", "map_id": "CHEBI:8927", "name": "CHEBI:8927", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34479", "map_id": "CHEBI:34479", "name": "CHEBI:34479", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10313584", "map_id": "none", "name": "GST dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8S817", "map_id": "A0A6I8S817", "name": "LOC100496158", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036388", "map_id": "ENSXETG00000036388", "name": "LOC100496158", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6SJ37", "map_id": "F6SJ37", "name": "HPGDS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000045440", "map_id": "ENSXETT00000045440", "name": "HPGDS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QYI0", "map_id": "A0A6I8QYI0", "name": "GSTT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038870", "map_id": "ENSXETG00000038870", "name": "GSTT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10331421", "map_id": "none", "name": "ABHD14B hydrolyses PNPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5695960", "map_id": "CHEBI:85867", "name": "PNPB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5695950", "map_id": "CHEBI:16836", "name": "PNP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76179", "map_id": "CHEBI:30772", "name": "BUT", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10331418", "map_id": "Q0VFB6", "name": "abhd14b", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000063063", "map_id": "ENSXETT00000063063", "name": "abhd14b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336924", "map_id": "none", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_742343", "map_id": "CHEBI:17985", "name": "PAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_2022884", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_8851226", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_8953493", "map_id": "CHEBI:16027", "name": "adenosine 5'-monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10336921", "map_id": "none", "name": "IMPAD1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "Q28CL4", "map_id": "Q28CL4", "name": "bpnt2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000012482", "map_id": "ENSXETT00000012482", "name": "bpnt2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8953505", "map_id": "CHEBI:49713", "name": "Li+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10313663", "map_id": "none", "name": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_158471", "map_id": "CHEBI:17980", "name": "PAPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176626", "map_id": "CHEBI:28689", "name": "DHEA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176496", "map_id": "CHEBI:16814", "name": "DHEA-SO4", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_158466", "map_id": "CHEBI:17985", "name": "PAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10313660", "map_id": "none", "name": "SULTs active on DHEA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8PTM1", "map_id": "A0A6I8PTM1", "name": "XB5850668", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033931", "map_id": "ENSXETG00000033931", "name": "XB5850668", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0BM84", "map_id": "B0BM84", "name": "sult2a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000064929", "map_id": "ENSXETT00000064929", "name": "sult2a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10313656", "map_id": "none", "name": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176565", "map_id": "CHEBI:17179", "name": "taurolithocholate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176483", "map_id": "CHEBI:17864", "name": "taurolithocholate sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10313634", "map_id": "none", "name": "SULT2A1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10313658", "map_id": "none", "name": "cholesterol + PAPS => cholesterol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176478", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176618", "map_id": "CHEBI:41321", "name": "cholesterol sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10313643", "map_id": "none", "name": "SULT2B1-2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10313654", "map_id": "none", "name": "lithocholate + PAPS => lithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176655", "map_id": "CHEBI:16325", "name": "LCA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_176555", "map_id": "CHEBI:35421", "name": "lithocholate sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10313649", "map_id": "none", "name": "SULTs transfer (SO4)2- group to PREG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193103", "map_id": "CHEBI:16581", "name": "PREG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176665", "map_id": "CHEBI:35420", "name": "PREGS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10313651", "map_id": "none", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176667", "map_id": "CHEBI:28774", "name": "T3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176564", "map_id": "CHEBI:35432", "name": "3,5,3'-triiodothyronine 4-sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10313636", "map_id": "none", "name": "SULT dimers (T2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F6QKH7", "map_id": "F6QKH7", "name": "SULT1C2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000042862", "map_id": "ENSXETT00000042862", "name": "SULT1C2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "L7N312", "map_id": "L7N312", "name": "sult6b1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000017267", "map_id": "ENSXETT00000017267", "name": "sult6b1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10313682", "map_id": "none", "name": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176566", "map_id": "CHEBI:17931", "name": "N-hydroxy-2-acetylaminofluorene", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176500", "map_id": "CHEBI:35424", "name": "AAF-N-S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10313679", "map_id": "none", "name": "SULTs active on NH2AAF", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10313677", "map_id": "none", "name": "estrone + PAPS => estrone 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176575", "map_id": "CHEBI:17263", "name": "E1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176501", "map_id": "CHEBI:17474", "name": "E1S", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10313646", "map_id": "none", "name": "SULTs transfer (SO4)2- group to 27HCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176617", "map_id": "CHEBI:17703", "name": "27HCHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_176502", "map_id": "CHEBI:35419", "name": "27HCHOL3S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10336939", "map_id": "none", "name": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10336928", "map_id": "A0A6I8QX40", "name": "podxl2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "ENSXETG00000039537", "map_id": "ENSXETG00000039537", "name": "podxl2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_741440", "map_id": "CHEBI:17980", "name": "PAPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10336932", "map_id": "A0A6I8QX40", "name": "podxl2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10336936", "map_id": "A0A6I8SWI1", "name": "tpst1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000017664", "map_id": "ENSXETG00000017664", "name": "tpst1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10313674", "map_id": "none", "name": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176600", "map_id": "CHEBI:35422", "name": "p-nitrophenol sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10313671", "map_id": "none", "name": "SULT1C2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10313639", "map_id": "none", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176486", "map_id": "CHEBI:35430", "name": "3,3'-diiodothyronine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176519", "map_id": "CHEBI:35431", "name": "3,3'-diiodothyronine 4-sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10313039", "map_id": "none", "name": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_159549", "map_id": "CHEBI:57305", "name": "Gly", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_159447", "map_id": "CHEBI:15515", "name": "BEZ-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29374", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159564", "map_id": "CHEBI:18089", "name": "HIPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10313036", "map_id": "none", "name": "GLYAT-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A0A6I8RQD3", "map_id": "A0A6I8RQD3", "name": "GLYAT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038499", "map_id": "ENSXETG00000038499", "name": "GLYAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10313024", "map_id": "none", "name": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113593", "map_id": "CHEBI:30616", "name": "ATP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_159446", "map_id": "CHEBI:30746", "name": "BENZA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159448", "map_id": "CHEBI:16027", "name": "adenosine 5'-monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159450", "map_id": "CHEBI:29888", "name": "PPi", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10313019", "map_id": "F6TG65", "name": "acsm3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "ENSXETT00000036505", "map_id": "ENSXETT00000036505", "name": "acsm3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10313808", "map_id": "none", "name": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_177153", "map_id": "CHEBI:8082", "name": "phenylacetate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_177137", "map_id": "CHEBI:15537", "name": "phenylacetyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10313045", "map_id": "none", "name": "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_159559", "map_id": "CHEBI:16914", "name": "SAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159557", "map_id": "CHEBI:32587", "name": "Salicylate-CoA thioester", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10313047", "map_id": "none", "name": "salicylate-CoA + glycine => salicyluric acid + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_159572", "map_id": "CHEBI:9008", "name": "SUA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10332302", "map_id": "none", "name": "CMBL hydrolyses OM to OLMS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6786175", "map_id": "CHEBI:31932", "name": "OM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6786194", "map_id": "CHEBI:48416", "name": "OLMS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6786179", "map_id": "CHEBI:46640", "name": "diketone", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10332299", "map_id": "Q6P7K0", "name": "cmbl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000054521", "map_id": "ENSXETT00000054521", "name": "cmbl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10331432", "map_id": "none", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113532", "map_id": "CHEBI:15343", "name": "CH3CHO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113526", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113529", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29362", "map_id": "CHEBI:57945", "name": "NADH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113539", "map_id": "CHEBI:30089", "name": "CH3COO-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10311857", "map_id": "none", "name": "ALDH2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A0A6I8RHR6", "map_id": "A0A6I8RHR6", "name": "aldh2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000020930", "map_id": "ENSXETG00000020930", "name": "aldh2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311851", "map_id": "none", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30203", "map_id": "CHEBI:16236", "name": "EtOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29360", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_70106", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29510", "map_id": "CHEBI:15343", "name": "CH3CHO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73473", "map_id": "CHEBI:57945", "name": "NADH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311848", "map_id": "none", "name": "alcohol dehydrogenase complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8RYK1", "map_id": "A0A6I8RYK1", "name": "LOC100486839", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000032351", "map_id": "ENSXETG00000032351", "name": "LOC100486839", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29426", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "F7DZV1", "map_id": "F7DZV1", "name": "adh5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000020485", "map_id": "ENSXETT00000020485", "name": "adh5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6YU63", "map_id": "F6YU63", "name": "ADH4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000024409", "map_id": "ENSXETT00000024409", "name": "ADH4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PVR9", "map_id": "A0A6I8PVR9", "name": "LOC100488099", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000032433", "map_id": "ENSXETG00000032433", "name": "LOC100488099", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10331211", "map_id": "none", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692221", "map_id": "CHEBI:48926", "name": "S-HMGSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692249", "map_id": "CHEBI:16225", "name": "S-FGSH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10331208", "map_id": "none", "name": "ADH5:2xZn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10311860", "map_id": "none", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10331448", "map_id": "none", "name": "AOC1 deaminates Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_109276", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_390899", "map_id": "CHEBI:18295", "name": "Hist", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_352327", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351626", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_2022135", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351629", "map_id": "CHEBI:16240", "name": "H2O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_5696128", "map_id": "CHEBI:27398", "name": "I4AH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10331445", "map_id": "none", "name": "AOC1 dimer:2xCu2+:4xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_74112", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:28694", "map_id": "CHEBI:28694", "name": "CHEBI:28694", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R549", "map_id": "A0A6I8R549", "name": "aoc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000011988", "map_id": "ENSXETG00000011988", "name": "aoc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316604", "map_id": "none", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_217315", "map_id": "CHEBI:50673", "name": "MTZ", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_217320", "map_id": "CHEBI:63828", "name": "MTZ-SOX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10316601", "map_id": "none", "name": "FMO2:FAD:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_113596", "map_id": "CHEBI:16238", "name": "FAD", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "A0A6I8RVH1", "map_id": "A0A6I8RVH1", "name": "fmo5.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000009900", "map_id": "ENSXETG00000009900", "name": "fmo5.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R1H4", "map_id": "A0A6I8R1H4", "name": "LOC100489254", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000025145", "map_id": "ENSXETG00000025145", "name": "LOC100489254", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312825", "map_id": "none", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_30373", "map_id": "CHEBI:18139", "name": "TMA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_140963", "map_id": "CHEBI:15724", "name": "TMAO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10312822", "map_id": "none", "name": "FMO3:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A6I8Q243", "map_id": "A0A6I8Q243", "name": "fmo3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000025142", "map_id": "ENSXETG00000025142", "name": "fmo3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316593", "map_id": "none", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_159154", "map_id": "CHEBI:41774", "name": "TAM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_217269", "map_id": "CHEBI:63825", "name": "TAMO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10316590", "map_id": "none", "name": "FMO1:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10312236", "map_id": "none", "name": "PTGIS, CYP8A1 isomerise PGH2 to PGI2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_30138", "map_id": "CHEBI:15554", "name": "PGH2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_31593", "map_id": "CHEBI:15552", "name": "PGI2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10312233", "map_id": "A0A6I8SE66", "name": "ptgis", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000001780", "map_id": "ENSXETG00000001780", "name": "ptgis", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316443", "map_id": "none", "name": "CYP26A1,B1 4-hydroxylate atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_215573", "map_id": "CHEBI:15367", "name": "atRA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_215584", "map_id": "CHEBI:63795", "name": "4OH-atRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10316440", "map_id": "Q08D50", "name": "cyp26b1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000021546", "map_id": "ENSXETG00000021546", "name": "cyp26b1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316086", "map_id": "none", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29368", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8963870", "map_id": "CHEBI:28940", "name": "VD3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8963879", "map_id": "CHEBI:17933", "name": "25(OH)D", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10316083", "map_id": "F7A051", "name": "crlf3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETT00000021283", "map_id": "ENSXETT00000021283", "name": "crlf3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312222", "map_id": "none", "name": "Coumarin is 7-hydroxylated by CYP2A6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_76328", "map_id": "CHEBI:28794", "name": "COUM", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_76452", "map_id": "CHEBI:27510", "name": "HCOU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10312219", "map_id": "none", "name": "Cytochrome P450 (CYP2A3 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A6I8T1P2", "map_id": "A0A6I8T1P2", "name": "cyp2g1p", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000027556", "map_id": "ENSXETG00000027556", "name": "cyp2g1p", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316377", "map_id": "none", "name": "CYP3A4 can N-demethylate loperamide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_213155", "map_id": "CHEBI:6532", "name": "LPAM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_213151", "map_id": "CHEBI:64043", "name": "N-demethylated loperamide", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10316374", "map_id": "none", "name": "Cytochrome P450 (CYPIIIA4 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "F7B981", "map_id": "F7B981", "name": "CYP3A4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000026362", "map_id": "ENSXETT00000026362", "name": "CYP3A4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q6H5", "map_id": "A0A6I8Q6H5", "name": "CYP3A4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316372", "map_id": "none", "name": "CYP2C19 5-hydroxylates omeprazole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211892", "map_id": "CHEBI:7772", "name": "Losec", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211944", "map_id": "CHEBI:63840", "name": "HOMZ", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10316367", "map_id": "none", "name": "Cytochrome P450 (CYP2C8 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A6I8PUP3", "map_id": "A0A6I8PUP3", "name": "cyp2c8.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033706", "map_id": "ENSXETG00000033706", "name": "cyp2c8.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316436", "map_id": "none", "name": "CYP2F1 dehydrogenates 3-methylindole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_213162", "map_id": "CHEBI:9171", "name": "MIND", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_213163", "map_id": "CHEBI:63905", "name": "3MEIN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10316433", "map_id": "none", "name": "Cytochrome P450 (CYP2F1 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A6I8QHP5", "map_id": "A0A6I8QHP5", "name": "cyp2a6.5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035878", "map_id": "ENSXETG00000035878", "name": "cyp2a6.5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316564", "map_id": "none", "name": "CYP3A4,5 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_156522", "map_id": "CHEBI:2504", "name": "AFB1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10316561", "map_id": "none", "name": "Cytochrome P450 (CYP3A5 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10316370", "map_id": "none", "name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211906", "map_id": "CHEBI:45863", "name": "PTXL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211894", "map_id": "CHEBI:63859", "name": "HPTXL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10316365", "map_id": "none", "name": "CYP3A7 can 6beta-hydroxylate testosterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_30321", "map_id": "CHEBI:17347", "name": "TES", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_213144", "map_id": "CHEBI:34477", "name": "6BHT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10316362", "map_id": "none", "name": "Cytochrome P450 (CYP3A7 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10316431", "map_id": "none", "name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211939", "map_id": "CHEBI:8107", "name": "Phenytoin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211927", "map_id": "CHEBI:63804", "name": "HPHT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10316428", "map_id": "none", "name": "Cytochrome P450 (CYP2C18 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10312207", "map_id": "none", "name": "N-hydroxylation of 4-aminobiphenyl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_47687", "map_id": "CHEBI:1784", "name": "ABPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_34889", "map_id": "CHEBI:16580", "name": "NHABP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10312215", "map_id": "none", "name": "N-atom dealkylation of caffeine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_40727", "map_id": "CHEBI:27732", "name": "CAF", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_76424", "map_id": "CHEBI:25858", "name": "Paraxanthine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10316426", "map_id": "none", "name": "Cyclophosphamide is 4-hydroxylated by CYP2B6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211977", "map_id": "CHEBI:4026", "name": "CPM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211967", "map_id": "CHEBI:1864", "name": "HCPM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10316423", "map_id": "none", "name": "Cytochrome P450 (CYP2B6 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10316421", "map_id": "none", "name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211855", "map_id": "CHEBI:27999", "name": "TBM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211937", "map_id": "CHEBI:63799", "name": "HTOLB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10312227", "map_id": "none", "name": "Ethylene is oxidized to Ethylene oxide by CYP1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_38985", "map_id": "CHEBI:18153", "name": "C2H4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10312224", "map_id": "A4IGV4", "name": "cyp1a1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10312217", "map_id": "none", "name": "Dehalogenation of carbon tetrachloride to form a free radical", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_40887", "map_id": "CHEBI:27385", "name": "CCl4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_29572", "map_id": "CHEBI:17996", "name": "Cl-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76433", "map_id": "none", "name": "Trichloromethyl radical", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10312197", "map_id": "none", "name": "Cytochrome P450 (CYP2E1 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10312200", "map_id": "none", "name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_39417", "map_id": "CHEBI:28509", "name": "VC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_156524", "map_id": "CHEBI:29129", "name": "2CEO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10312213", "map_id": "none", "name": "Benzene is hydroxylated to phenol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_31711", "map_id": "CHEBI:16716", "name": "C6H6", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_29630", "map_id": "CHEBI:15882", "name": "PhOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10312229", "map_id": "none", "name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_40795", "map_id": "CHEBI:5615", "name": "HALO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76474", "map_id": "CHEBI:47266", "name": "HBr", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76473", "map_id": "CHEBI:29138", "name": "TFAC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10312881", "map_id": "none", "name": "MEOS oxidizes ethanol to acetaldehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_113748", "map_id": "CHEBI:16236", "name": "EtOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113745", "map_id": "CHEBI:15343", "name": "CH3CHO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10312211", "map_id": "none", "name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_39427", "map_id": "CHEBI:46195", "name": "Acetaminophen (TN TYLENOL)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113555", "map_id": "CHEBI:18276", "name": "H2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10316354", "map_id": "none", "name": "Coumarin is 7-hydroxylated by CYP2A13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10316351", "map_id": "none", "name": "Cytochrome P450 (CYP2A13 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "F6SM60", "map_id": "F6SM60", "name": "LOC100494106", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000031981", "map_id": "ENSXETT00000031981", "name": "LOC100494106", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RC71", "map_id": "A0A6I8RC71", "name": "cyp2a6.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000024858", "map_id": "ENSXETG00000024858", "name": "cyp2a6.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q180", "map_id": "A0A6I8Q180", "name": "cyp2a6.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000027561", "map_id": "ENSXETG00000027561", "name": "cyp2a6.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6XRS5", "map_id": "F6XRS5", "name": "XB5919979", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000042326", "map_id": "ENSXETT00000042326", "name": "XB5919979", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316349", "map_id": "none", "name": "CYP2S1 4-hydroxylates atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_10312173", "map_id": "A0A6I8QHP5", "name": "cyp2a6.5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10316394", "map_id": "none", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_140356", "map_id": "CHEBI:15843", "name": "ARA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_216620", "map_id": "CHEBI:63998", "name": "19HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10316391", "map_id": "F6W5W2", "name": "cyp2r1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETT00000042586", "map_id": "ENSXETT00000042586", "name": "cyp2r1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316419", "map_id": "none", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_216547", "map_id": "CHEBI:16881", "name": "INDOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_216598", "map_id": "CHEBI:31697", "name": "Oxindole", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10316416", "map_id": "none", "name": "Homologues of CYP2W1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A6I8PZZ5", "map_id": "A0A6I8PZZ5", "name": "cyp2b6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034285", "map_id": "ENSXETG00000034285", "name": "cyp2b6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7AA19", "map_id": "F7AA19", "name": "CYP2W1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000010485", "map_id": "ENSXETT00000010485", "name": "CYP2W1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S3Z7", "map_id": "A0A6I8S3Z7", "name": "LOC100491773", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034657", "map_id": "ENSXETG00000034657", "name": "LOC100491773", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QTX8", "map_id": "A0A6I8QTX8", "name": "CYP2W1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q285", "map_id": "A0A6I8Q285", "name": "LOC100492165", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031264", "map_id": "ENSXETG00000031264", "name": "LOC100492165", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316387", "map_id": "none", "name": "CYP3A43 6b-hydroxylates TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_10316360", "map_id": "none", "name": "Homologues of CYP3A7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10314222", "map_id": "none", "name": "CYP46A1 24-hydroxylates CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193384", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_192060", "map_id": "CHEBI:34310", "name": "24OH-CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10314219", "map_id": "A0A6I8PZJ9", "name": "LOC100498621", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000032861", "map_id": "ENSXETG00000032861", "name": "LOC100498621", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314297", "map_id": "none", "name": "CYP11B1 oxidises 11DCORT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113533", "map_id": "CHEBI:15379", "name": "O2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_193998", "map_id": "CHEBI:28324", "name": "11DCORT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113600", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113563", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_194011", "map_id": "CHEBI:17650", "name": "CORT", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10314289", "map_id": "A0A6I8SR26", "name": "LOC101731070", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "ENSXETG00000037871", "map_id": "ENSXETG00000037871", "name": "LOC101731070", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314299", "map_id": "none", "name": "CYP11B2 oxidises 11DCORST to CORST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_193988", "map_id": "CHEBI:16973", "name": "11DCORST", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_194005", "map_id": "CHEBI:16827", "name": "CORST", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10314292", "map_id": "none", "name": "CYP11B2 oxidises 18HCORST to ALDO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_194012", "map_id": "CHEBI:16485", "name": "18HCORST", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_193982", "map_id": "CHEBI:27584", "name": "ALDO", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10314294", "map_id": "none", "name": "CYP11B2 18-hydroxylates CORST to 18HCORST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10316384", "map_id": "none", "name": "CYP1B1 4-hydroxylates EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193132", "map_id": "CHEBI:16469", "name": "EST17b", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_211973", "map_id": "CHEBI:62845", "name": "4OH-EST17b", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10316381", "map_id": "A0A6I8SJ30", "name": "cyp1b1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000038590", "map_id": "ENSXETG00000038590", "name": "cyp1b1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314224", "map_id": "none", "name": "CYP27A1 27-hydroxylates CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_193840", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_193846", "map_id": "CHEBI:17703", "name": "27OH-CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10314187", "map_id": "A0A6I8SX48", "name": "cyp27a1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "ENSXETG00000039601", "map_id": "ENSXETG00000039601", "name": "cyp27a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10331223", "map_id": "none", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692409", "map_id": "CHEBI:196991", "name": "4HPCP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692433", "map_id": "CHEBI:3410", "name": "CXPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10331220", "map_id": "F6X8Y6", "name": "aldh3a2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000029530", "map_id": "ENSXETT00000029530", "name": "aldh3a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10331315", "map_id": "none", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_5693702", "map_id": "CHEBI:27958", "name": "COCN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5693711", "map_id": "CHEBI:17790", "name": "MeOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5693712", "map_id": "CHEBI:41001", "name": "BEG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10331312", "map_id": "none", "name": "CES1 trimer, CES2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "A0A6I8Q0V4", "map_id": "A0A6I8Q0V4", "name": "LOC100493819", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000030902", "map_id": "ENSXETG00000030902", "name": "LOC100493819", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A5G3JDL4", "map_id": "A0A5G3JDL4", "name": "ces3.4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000103127", "map_id": "ENSXETT00000103127", "name": "ces3.4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336179", "map_id": "none", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_163579", "map_id": "CHEBI:17002", "name": "CHEST", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_8876730", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_216762", "map_id": "CHEBI:16113", "name": "CHOL", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10336176", "map_id": "none", "name": "Homologues of CES3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10336114", "map_id": "none", "name": "MARC1,MARC2 reduce N-hydroxylated compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8936443", "map_id": "CHEBI:47823", "name": "NOHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29468", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10336111", "map_id": "none", "name": "MARC1:Mo-MPT:MARC2:Mo-MPT:CYB5B:CYB5R3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "A0A1B8Y4Y6", "map_id": "A0A1B8Y4Y6", "name": "mtarc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000087008", "map_id": "ENSXETT00000087008", "name": "mtarc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:21437", "map_id": "CHEBI:21437", "name": "CHEBI:21437", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6WBG7", "map_id": "F6WBG7", "name": "CYB5B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000038708", "map_id": "ENSXETT00000038708", "name": "CYB5B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329678", "map_id": "none", "name": "CYP1A2, 3A4 oxidise AFB1 to AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5423605", "map_id": "CHEBI:2504", "name": "AFB1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5423663", "map_id": "CHEBI:78586", "name": "AFNBO", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10329675", "map_id": "none", "name": "CYP1A2,3A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A4IGV4", "map_id": "A4IGV4", "name": "cyp1a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329673", "map_id": "none", "name": "CYP3A4,5 hydroxylates AFB1 to AFQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5423660", "map_id": "CHEBI:78582", "name": "AFQ1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10329670", "map_id": "none", "name": "CYP3A4,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10329707", "map_id": "none", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5490236", "map_id": "none", "name": "AFXBO-NAC,AFNBO-NAC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:78580", "map_id": "CHEBI:78580", "name": "CHEBI:78580", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78585", "map_id": "CHEBI:78585", "name": "CHEBI:78585", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2022890", "map_id": "CHEBI:15366", "name": "CH3COO-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_5490231", "map_id": "none", "name": "AFXBO-C,AFNBO-C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:78583", "map_id": "CHEBI:78583", "name": "CHEBI:78583", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78578", "map_id": "CHEBI:78578", "name": "CHEBI:78578", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10329704", "map_id": "none", "name": "ACY1:Zn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8PUM5", "map_id": "A0A6I8PUM5", "name": "LOC101735201", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000032120", "map_id": "ENSXETG00000032120", "name": "LOC101735201", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329668", "map_id": "none", "name": "MGST trimers transfer GS from GSH to AFXBO and AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5423723", "map_id": "none", "name": "AFXBO,AFNBO", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5423730", "map_id": "none", "name": "AFXBO-SG,AFNBO-SG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:78581", "map_id": "CHEBI:78581", "name": "CHEBI:78581", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78587", "map_id": "CHEBI:78587", "name": "CHEBI:78587", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312902", "map_id": "none", "name": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_159211", "map_id": "CHEBI:30725", "name": "AFXBO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312899", "map_id": "none", "name": "CYP1A2,3A4,3A5,2A13", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10337910", "map_id": "none", "name": "ACY3:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337907", "map_id": "none", "name": "ACY3:Zn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q5BJ91", "map_id": "Q5BJ91", "name": "acy3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000019664", "map_id": "ENSXETT00000019664", "name": "acy3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329680", "map_id": "none", "name": "CYP1A2 hydroxylates AFB1 to AFM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5423629", "map_id": "CHEBI:78576", "name": "AFM1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10329666", "map_id": "none", "name": "CYP2A13 oxidises AFM1 to AFM1E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5423657", "map_id": "CHEBI:78577", "name": "AFM1E", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312195", "map_id": "none", "name": "Homologues of CYP2A13", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10315625", "map_id": "none", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_199622", "map_id": "CHEBI:18385", "name": "THMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_196934", "map_id": "CHEBI:18385", "name": "THMN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10315622", "map_id": "none", "name": "SLC19A2/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PTQ0", "map_id": "A0A6I8PTQ0", "name": "LOC100489406", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000014772", "map_id": "ENSXETG00000014772", "name": "LOC100489406", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6TI71", "map_id": "F6TI71", "name": "slc19a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000005158", "map_id": "ENSXETT00000005158", "name": "slc19a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314029", "map_id": "none", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10314001", "map_id": "none", "name": "CCNA:p-T160-CDK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "F6T0J1", "map_id": "F6T0J1", "name": "cdk19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000046130", "map_id": "ENSXETT00000046130", "name": "cdk19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10314025", "map_id": "A0A6I8QJI3", "name": "e2f3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000000021", "map_id": "ENSXETG00000000021", "name": "phospho-e2f3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10314027", "map_id": "none", "name": "CCNA:p-T160-CDK2:E2F1/E2F3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8QJI3", "map_id": "A0A6I8QJI3", "name": "phospho-e2f3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314040", "map_id": "none", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_29358", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113582", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10314037", "map_id": "none", "name": "CCNA:p-T160-CDK2:p-E2F1/p-E2F3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10327234", "map_id": "none", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10327232", "map_id": "P62205", "name": "phospho-plk1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000022754", "map_id": "ENSXETT00000022754", "name": "phospho-plk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10313135", "map_id": "P62205", "name": "phospho-plk1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10328464", "map_id": "none", "name": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328459", "map_id": "A0A6I8RBK3", "name": "foxm1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000035621", "map_id": "ENSXETG00000035621", "name": "foxm1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328462", "map_id": "A0A6I8RBK3", "name": "phospho-foxm1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10335127", "map_id": "none", "name": "GTSE1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10335118", "map_id": "Q28DF6", "name": "phospho-gtse1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000061292", "map_id": "ENSXETT00000061292", "name": "gtse1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335125", "map_id": "Q28DF6", "name": "phospho-gtse1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10335121", "map_id": "none", "name": "PLK1 phosphorylates GTSE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10335115", "map_id": "none", "name": "GTSE1:p-T210-PLK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q28DF6", "map_id": "Q28DF6", "name": "gtse1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P62205", "map_id": "P62205", "name": "phospho-plk1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29370", "map_id": "CHEBI:456216", "name": "ADP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10335123", "map_id": "none", "name": "GTSE1 binds PLK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10335113", "map_id": "Q28DF6", "name": "gtse1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10328475", "map_id": "none", "name": "PLK1 phosphorylates FOXM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328466", "map_id": "none", "name": "p-T611-FOXM1:p-T210-PLK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8RBK3", "map_id": "A0A6I8RBK3", "name": "foxm1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328472", "map_id": "A0A6I8RBK3", "name": "phospho-foxm1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10328468", "map_id": "none", "name": "PLK1 binds FOXM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10324271", "map_id": "none", "name": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629770", "map_id": "CHEBI:17401", "name": "IP6", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629740", "map_id": "CHEBI:62919", "name": "1-PP-IP5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10324253", "map_id": "F7EB21", "name": "ppip5k1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000018584", "map_id": "ENSXETT00000018584", "name": "ppip5k1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324302", "map_id": "none", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629765", "map_id": "CHEBI:30164", "name": "5-PP-IP5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10324235", "map_id": "F7D664", "name": "ip6k2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000020549", "map_id": "ENSXETT00000020549", "name": "ip6k2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324296", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_994141", "map_id": "CHEBI:16322", "name": "I(1,3,4,5,6)P5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629755", "map_id": "CHEBI:62928", "name": "5-PP-IP4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10324262", "map_id": "none", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629732", "map_id": "CHEBI:62923", "name": "1,5-(PP)2-IP4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10324240", "map_id": "none", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629759", "map_id": "CHEBI:62985", "name": "5-PPP-IP5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10324256", "map_id": "none", "name": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10324259", "map_id": "none", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629736", "map_id": "CHEBI:62926", "name": "1-PP-IP4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629738", "map_id": "CHEBI:62931", "name": "1,5-(PP)2-IP3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10331934", "map_id": "none", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10331927", "map_id": "none", "name": "CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SGS6", "map_id": "A0A6I8SGS6", "name": "cyld", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031250", "map_id": "ENSXETG00000031250", "name": "cyld", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RKP9", "map_id": "A0A6I8RKP9", "name": "ikbkg", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031817", "map_id": "ENSXETG00000031817", "name": "ikbkg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28DL4", "map_id": "Q28DL4", "name": "traf6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000007549", "map_id": "ENSXETG00000007549", "name": "traf6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10331931", "map_id": "none", "name": "TRAF2,TRAF6,IKBKG,RIPK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10313391", "map_id": "none", "name": "K63polyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8PW00", "map_id": "A0A6I8PW00", "name": "UBC(533-608)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036372", "map_id": "ENSXETG00000036372", "name": "UBC(533-608)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RD22", "map_id": "A0A6I8RD22", "name": "ubc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037858", "map_id": "ENSXETG00000037858", "name": "ubc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10320632", "map_id": "none", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10320623", "map_id": "A0A6I8SFY9", "name": "ddx58", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000009200", "map_id": "ENSXETG00000009200", "name": "ddx58", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320625", "map_id": "A0A6I8SFY9", "name": "ddx58", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312116", "map_id": "none", "name": "Ub", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10320629", "map_id": "A0A6I8SGS6", "name": "cyld", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10331914", "map_id": "none", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_113518", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10331767", "map_id": "none", "name": "USP12:WDR48:WDR20,USP26:PolyUb-AR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8RK73", "map_id": "A0A6I8RK73", "name": "ar", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000005089", "map_id": "ENSXETG00000005089", "name": "ar", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10331911", "map_id": "none", "name": "PolyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10331769", "map_id": "none", "name": "USP12:WDR48:WDR20,USP26:AR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10332196", "map_id": "none", "name": "USP30 deubiquitinates Ub-MOM proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10331979", "map_id": "none", "name": "USP30:PolyUb-MOM proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q6DFM9", "map_id": "Q6DFM9", "name": "tomm20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000098526", "map_id": "ENSXETT00000098526", "name": "tomm20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A4QNN3", "map_id": "A4QNN3", "name": "usp30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000048254", "map_id": "ENSXETT00000048254", "name": "usp30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10332193", "map_id": "none", "name": "PolyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10331995", "map_id": "none", "name": "USP30:MOM proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10330999", "map_id": "none", "name": "USP16,USP21 deubiquitinate Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10330994", "map_id": "none", "name": "USP16,USP21:Ub-histone H2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q0VA64", "map_id": "Q0VA64", "name": "usp16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000020255", "map_id": "ENSXETG00000020255", "name": "usp16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10327687", "map_id": "none", "name": "Ub", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10330996", "map_id": "none", "name": "USP16,USP22:Histone H2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10332214", "map_id": "none", "name": "USP24 deubiquitinates DDB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10332207", "map_id": "none", "name": "USP24:PolyUb-DDB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q66JG1", "map_id": "Q66JG1", "name": "ddb2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000008619", "map_id": "ENSXETT00000008619", "name": "ddb2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SCT2", "map_id": "A0A6I8SCT2", "name": "usp24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000009543", "map_id": "ENSXETG00000009543", "name": "usp24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10332211", "map_id": "none", "name": "USP24:DDB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10331760", "map_id": "none", "name": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10331549", "map_id": "none", "name": "USP17:PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F7BNK9", "map_id": "F7BNK9", "name": "emp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000015033", "map_id": "ENSXETT00000015033", "name": "emp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SFY9", "map_id": "A0A6I8SFY9", "name": "ddx58", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7ZT68", "map_id": "B7ZT68", "name": "rce1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000056088", "map_id": "ENSXETT00000056088", "name": "rce1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10331555", "map_id": "none", "name": "USP17L1,USP17L2:RCE1, CDC25A, DDX58, IFIH1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10331757", "map_id": "none", "name": "PolyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10331173", "map_id": "none", "name": "BRISC complex deubiquitinates NLRP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10331164", "map_id": "none", "name": "BRISC complex:K63polyUb-NLRP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q5M8J0", "map_id": "Q5M8J0", "name": "babam1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000025571", "map_id": "ENSXETG00000025571", "name": "babam1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4VA72", "map_id": "Q4VA72", "name": "brcc3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000026184", "map_id": "ENSXETG00000026184", "name": "brcc3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6P4W0", "map_id": "Q6P4W0", "name": "abraxas2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000023627", "map_id": "ENSXETG00000023627", "name": "abraxas2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6DJ78", "map_id": "Q6DJ78", "name": "babam2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000010201", "map_id": "ENSXETG00000010201", "name": "babam2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10331168", "map_id": "none", "name": "BRISC complex:NLRP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10331071", "map_id": "none", "name": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10331006", "map_id": "none", "name": "BAP1:K48polyUb,K63polyUb-HCFC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8QTP5", "map_id": "A0A6I8QTP5", "name": "hcfc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000014251", "map_id": "ENSXETG00000014251", "name": "hcfc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q66JB6", "map_id": "Q66JB6", "name": "bap1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000000091", "map_id": "ENSXETG00000000091", "name": "bap1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10331010", "map_id": "none", "name": "BAP1:HCFC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10331068", "map_id": "none", "name": "K48-polyUb, K63-polyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10331073", "map_id": "none", "name": "BAP1 binds Ub-HCFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10330919", "map_id": "Q66JB6", "name": "bap1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10331004", "map_id": "A0A6I8QTP5", "name": "hcfc1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10335867", "map_id": "none", "name": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10335864", "map_id": "none", "name": "OTUD7B,TNFAIP3,ZRANB1:K63polyUb-TRAF6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "B1H2Q2", "map_id": "B1H2Q2", "name": "zranb1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000023629", "map_id": "ENSXETG00000023629", "name": "zranb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QSL0", "map_id": "A0A6I8QSL0", "name": "otud7b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000015765", "map_id": "ENSXETG00000015765", "name": "otud7b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10331090", "map_id": "none", "name": "OTUD7B,TNFAIP3,ZRANB1:TRAF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10331093", "map_id": "none", "name": "OTUD7B,TNFAIP3 deubiquitinate TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10331088", "map_id": "none", "name": "OTUD7B,TNFAIP3,ZRANB1:K48polyUb-TRAF6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10330519", "map_id": "none", "name": "K48polyUb", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10330909", "map_id": "none", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10313389", "map_id": "none", "name": "K63-Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10330906", "map_id": "F7CV37", "name": "JOSD2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000006019", "map_id": "ENSXETT00000006019", "name": "JOSD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325869", "map_id": "none", "name": "KIBRA (WWC1) binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10325797", "map_id": "F6U2R0", "name": "lats1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000026288", "map_id": "ENSXETT00000026288", "name": "lats1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10325865", "map_id": "A4IIJ3", "name": "wwc1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000016462", "map_id": "ENSXETG00000016462", "name": "wwc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10325867", "map_id": "none", "name": "KIBRA:LATS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A4IIJ3", "map_id": "A4IIJ3", "name": "wwc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6U2R0", "map_id": "F6U2R0", "name": "lats1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325851", "map_id": "none", "name": "Translocation of YAP1 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10325815", "map_id": "A0A6I8SYU4", "name": "yap1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000032689", "map_id": "ENSXETG00000032689", "name": "yap1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10325849", "map_id": "A0A6I8SYU4", "name": "yap1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10325835", "map_id": "none", "name": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312802", "map_id": "none", "name": "YWHAB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q5XGC8", "map_id": "Q5XGC8", "name": "ywhab", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000022830", "map_id": "ENSXETG00000022830", "name": "ywhab", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10325818", "map_id": "A0A6I8SYU4", "name": "phospho-yap1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10325833", "map_id": "none", "name": "p-YAP1:YWHAB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SYU4", "map_id": "A0A6I8SYU4", "name": "yap1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325829", "map_id": "none", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10325803", "map_id": "Q28FB5", "name": "phospho-mob1a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000073958", "map_id": "ENSXETT00000073958", "name": "phospho-mob1a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10325805", "map_id": "none", "name": "LATS:p-MOB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q28FB5", "map_id": "Q28FB5", "name": "phospho-mob1a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325942", "map_id": "none", "name": "NPHP4 protein binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10325938", "map_id": "A0A6I8SDY8", "name": "nphp4.2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000002886", "map_id": "ENSXETG00000002886", "name": "nphp4.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10325940", "map_id": "none", "name": "NPHP4:LATS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SDY8", "map_id": "A0A6I8SDY8", "name": "nphp4.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325843", "map_id": "none", "name": "AMOT proteins bind YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10325839", "map_id": "A0A6I8SVS3", "name": "amotl1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000006385", "map_id": "ENSXETG00000006385", "name": "amotl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10325841", "map_id": "none", "name": "AMOT:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SVS3", "map_id": "A0A6I8SVS3", "name": "amotl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325827", "map_id": "none", "name": "Phosphorylation of YAP by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10325824", "map_id": "A0A6I8SYU4", "name": "phospho-yap1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10325811", "map_id": "none", "name": "p-LATS:p-MOB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10335596", "map_id": "none", "name": "SL (surrogate light chain) binds IgH to form pre-BCR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10335536", "map_id": "none", "name": "IgM Heavy Chain", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10335592", "map_id": "none", "name": "Pre-B Cell Surrogate Light Chain", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8QGS1", "map_id": "A0A6I8QGS1", "name": "VPREB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040831", "map_id": "ENSXETG00000040831", "name": "VPREB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SZD5", "map_id": "A0A6I8SZD5", "name": "LOC105948249", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034688", "map_id": "ENSXETG00000034688", "name": "LOC105948249", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QDF6", "map_id": "A0A6I8QDF6", "name": "LOC105948245", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037057", "map_id": "ENSXETG00000037057", "name": "LOC105948245", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S531", "map_id": "A0A6I8S531", "name": "VPREB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q881", "map_id": "A0A6I8Q881", "name": "VPREB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RG89", "map_id": "A0A6I8RG89", "name": "VPREB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R6G0", "map_id": "A0A6I8R6G0", "name": "LOC105948244", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040853", "map_id": "ENSXETG00000040853", "name": "LOC105948244", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335594", "map_id": "none", "name": "Immunoglobulin Mu with Surrogate Light Chain", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10315803", "map_id": "none", "name": "Heterodimerization of CEACAMs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10315799", "map_id": "none", "name": "Neutrophil CEACAMs affecting integrin binding to fibronectin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8QZM7", "map_id": "A0A6I8QZM7", "name": "ceacam8l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000032631", "map_id": "ENSXETG00000032631", "name": "ceacam8l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R329", "map_id": "A0A6I8R329", "name": "CEACAM8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038658", "map_id": "ENSXETG00000038658", "name": "CEACAM8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PPZ5", "map_id": "A0A6I8PPZ5", "name": "CEACAM8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SB02", "map_id": "A0A6I8SB02", "name": "CEACAM8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10315801", "map_id": "none", "name": "CEACAM heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10327047", "map_id": "none", "name": "E-selectin binds E-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10315815", "map_id": "A0A6I8R2I7", "name": "SELPLG", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000038109", "map_id": "ENSXETG00000038109", "name": "SELPLG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10315821", "map_id": "A0A6I8SFE9", "name": "SELE", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000039556", "map_id": "ENSXETG00000039556", "name": "SELP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10327045", "map_id": "none", "name": "2xSELE ligands:SELE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8SFE9", "map_id": "A0A6I8SFE9", "name": "SELP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R2I7", "map_id": "A0A6I8R2I7", "name": "SELPLG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10315831", "map_id": "none", "name": "JAM3 dimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10315807", "map_id": "A0A6I8SUC1", "name": "jam3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000040710", "map_id": "ENSXETG00000040710", "name": "jam3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10315829", "map_id": "none", "name": "JAM3 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8SUC1", "map_id": "A0A6I8SUC1", "name": "jam3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335414", "map_id": "none", "name": "FCAMR binds IgA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10335410", "map_id": "A0A6I8QSY3", "name": "FCAMR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10326437", "map_id": "none", "name": "2xIgA:JCHAIN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8R5U7", "map_id": "A0A6I8R5U7", "name": "jchain", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034776", "map_id": "ENSXETG00000034776", "name": "jchain", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335412", "map_id": "none", "name": "FCAMR:2xIgA:JCHAIN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10335808", "map_id": "none", "name": "EPCAM binds itself to form homotypic cell adhesion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10335804", "map_id": "Q5U4Z2", "name": "epcam", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000060362", "map_id": "ENSXETT00000060362", "name": "epcam", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335806", "map_id": "none", "name": "EPCAM dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q5U4Z2", "map_id": "Q5U4Z2", "name": "epcam", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10315827", "map_id": "none", "name": "P-selectin binds P-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10315823", "map_id": "none", "name": "Selectins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10315825", "map_id": "none", "name": "Selectins:2xSELPG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10327054", "map_id": "none", "name": "SLC9B1/C2 exchange Na+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_74113", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_83910", "map_id": "CHEBI:29101", "name": "Na+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10327051", "map_id": "A4IHB9", "name": "slc9b2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000021321", "map_id": "ENSXETG00000021321", "name": "slc9b2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327555", "map_id": "none", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_74016", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10327552", "map_id": "none", "name": "TRPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8QKQ2", "map_id": "A0A6I8QKQ2", "name": "trpv5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031787", "map_id": "ENSXETG00000031787", "name": "trpv5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SES7", "map_id": "A0A6I8SES7", "name": "trpv2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000005811", "map_id": "ENSXETG00000005811", "name": "trpv2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SY50", "map_id": "A0A6I8SY50", "name": "trpm6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000001048", "map_id": "ENSXETG00000001048", "name": "trpm6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RF46", "map_id": "A0A6I8RF46", "name": "mcoln3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000008633", "map_id": "ENSXETG00000008633", "name": "mcoln3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327002", "map_id": "none", "name": "ASIC trimers:H+ transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10326999", "map_id": "none", "name": "ASIC5 trimer:H+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F6W3B8", "map_id": "F6W3B8", "name": "ASIC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000027176", "map_id": "ENSXETT00000027176", "name": "ASIC5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2672379", "map_id": "none", "name": "amiloride", "type": "inhibitor", "sub_type": "other", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_2672383", "map_id": "CHEBI:35475", "name": "NSAID", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10335653", "map_id": "none", "name": "ASICs bind STOML3, (STOM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10335649", "map_id": "A0A1B8Y5B7", "name": "stom", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000104043", "map_id": "ENSXETT00000104043", "name": "stom", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335651", "map_id": "none", "name": "ASIC trimers:H+:STOML3,(STOM)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A1B8Y5B7", "map_id": "A0A1B8Y5B7", "name": "stom", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10338020", "map_id": "none", "name": "ASIC trimers bind H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10338018", "map_id": "none", "name": "ASIC5 trimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10327041", "map_id": "none", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_352022", "map_id": "CHEBI:17996", "name": "Cl-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_188972", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10327038", "map_id": "Q0V9V9", "name": "ttyh1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000003389", "map_id": "ENSXETG00000003389", "name": "ttyh1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327027", "map_id": "none", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10327018", "map_id": "none", "name": "ANOs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8SNU5", "map_id": "A0A6I8SNU5", "name": "ano6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031444", "map_id": "ENSXETG00000031444", "name": "ano6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SCS5", "map_id": "A0A6I8SCS5", "name": "LOC101732476", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034667", "map_id": "ENSXETG00000034667", "name": "LOC101732476", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PYE3", "map_id": "A0A6I8PYE3", "name": "ANO9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031447", "map_id": "ENSXETG00000031447", "name": "ANO9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10327023", "map_id": "A0A6I8S060", "name": "clca4.1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000039090", "map_id": "ENSXETG00000039090", "name": "clca4.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329555", "map_id": "none", "name": "CLCAs self cleave", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10329542", "map_id": "A0A6I8S060", "name": "clca4.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10329548", "map_id": "A0A6I8S060", "name": "clca4.1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10327059", "map_id": "none", "name": "SLC9B2 exchanges Na+, Li+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_2889081", "map_id": "none", "name": "Na+/Li+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "species_2889062", "map_id": "none", "name": "Na+/Li+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_163953", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10327056", "map_id": "A4IHB9", "name": "slc9b2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10325871", "map_id": "none", "name": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046066", "map_id": "CHEBI:15531", "name": "Malonyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046053", "map_id": "CHEBI:15514", "name": "AA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_162743", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_159751", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046060", "map_id": "CHEBI:63544", "name": "DTA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10319021", "map_id": "Q5M8U1", "name": "elovl5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETT00000034904", "map_id": "ENSXETT00000034904", "name": "elovl5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325880", "map_id": "none", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046042", "map_id": "CHEBI:15508", "name": "GLA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046045", "map_id": "CHEBI:27979", "name": "DGL-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10325878", "map_id": "none", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046050", "map_id": "CHEBI:63546", "name": "TPA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211579", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_5228339", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_2046055", "map_id": "CHEBI:63546", "name": "TPA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_211606", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10317279", "map_id": "A0A6I8Q353", "name": "abcd1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "ENSXETG00000007705", "map_id": "ENSXETG00000007705", "name": "abcd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10320759", "map_id": "none", "name": "GABRR pentamers:GABA transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10320756", "map_id": "none", "name": "GABRR pentamers:GABA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_428571", "map_id": "CHEBI:59888", "name": "GABA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "A0A6I8QVR1", "map_id": "A0A6I8QVR1", "name": "LOC100486148", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000030855", "map_id": "ENSXETG00000030855", "name": "LOC100486148", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10320748", "map_id": "none", "name": "HTR3 pentamers:5HT transport Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_29804", "map_id": "CHEBI:29103", "name": "K+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10320745", "map_id": "none", "name": "HTR3 pentamers:5HT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_114523", "map_id": "CHEBI:28790", "name": "5HT", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "A0A6I8QAS1", "map_id": "A0A6I8QAS1", "name": "htr3a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031115", "map_id": "ENSXETG00000031115", "name": "htr3a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RJM1", "map_id": "A0A6I8RJM1", "name": "htr3b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031022", "map_id": "ENSXETG00000031022", "name": "htr3b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10338012", "map_id": "none", "name": "HTR3A pentamer:5HT transports Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10338009", "map_id": "none", "name": "HTR3A pentamer:5HT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10337600", "map_id": "none", "name": "p-S363,S380,T573 RS6K translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10337590", "map_id": "none", "name": "p-S221,T359.S363,S380,T573,T732-RSK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F7DTA9", "map_id": "F7DTA9", "name": "phospho-LOC100498287", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000051850", "map_id": "ENSXETT00000051850", "name": "phospho-LOC100498287", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6YXI9", "map_id": "F6YXI9", "name": "phospho-p-S221,T459,S363,S380,T573,T732-RPS6KA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000008599", "map_id": "ENSXETT00000008599", "name": "phospho-p-S221,T459,S363,S380,T573,T732-RPS6KA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337598", "map_id": "none", "name": "p-S221,T359,S363,S380,T573,T732-RSK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10338016", "map_id": "none", "name": "HTR3A pentamer binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10338014", "map_id": "none", "name": "HTR3A pentamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10316794", "map_id": "none", "name": "Loading of dopamine into synaptic veiscles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_374932", "compartment_display": "clathrin-sculpted monoamine transport vesicle lumen" }, { "id": "species_159362", "map_id": "CHEBI:18243", "name": "DA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_351601", "map_id": "CHEBI:18243", "name": "DA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10316791", "map_id": "A0A6I8R508", "name": "SLC18A2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_374940", "compartment_display": "clathrin-sculpted monoamine transport vesicle membrane", "complex": "false" }, { "id": "ENSXETG00000038313", "map_id": "ENSXETG00000038313", "name": "SLC18A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317198", "map_id": "none", "name": "loading of Serotonin in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_374932", "compartment_display": "clathrin-sculpted monoamine transport vesicle lumen" }, { "id": "species_209914", "map_id": "CHEBI:28790", "name": "5HT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_380585", "map_id": "CHEBI:28790", "name": "5HT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_374932", "compartment_display": "clathrin-sculpted monoamine transport vesicle lumen", "complex": "false" }, { "id": "reaction_10333989", "map_id": "none", "name": "NAAA hydrolyses NAEs to FAs and ethanolamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605715", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6803725", "map_id": "none", "name": "NAEs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "CHEBI:71466", "map_id": "CHEBI:71466", "name": "CHEBI:71466", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:2700", "map_id": "CHEBI:2700", "name": "CHEBI:2700", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:85299", "map_id": "CHEBI:85299", "name": "CHEBI:85299", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:85263", "map_id": "CHEBI:85263", "name": "CHEBI:85263", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:71464", "map_id": "CHEBI:71464", "name": "CHEBI:71464", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:85262", "map_id": "CHEBI:85262", "name": "CHEBI:85262", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6803745", "map_id": "CHEBI:16000", "name": "ETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6803778", "map_id": "none", "name": "FAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_3632881", "map_id": "CHEBI:15756", "name": "PALM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:30805", "map_id": "CHEBI:30805", "name": "CHEBI:30805", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:9254", "map_id": "CHEBI:9254", "name": "CHEBI:9254", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28875", "map_id": "CHEBI:28875", "name": "CHEBI:28875", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16196", "map_id": "CHEBI:16196", "name": "CHEBI:16196", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10333986", "map_id": "none", "name": "NAAA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q6DJ82", "map_id": "Q6DJ82", "name": "naaa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000057513", "map_id": "ENSXETT00000057513", "name": "naaa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10320187", "map_id": "none", "name": "Synthesis of GABA by GAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane" }, { "id": "species_29404", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_352011", "map_id": "CHEBI:59888", "name": "GABA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113528", "map_id": "CHEBI:16526", "name": "CO2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10320184", "map_id": "none", "name": "PXLP-K396-GAD2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane", "complex": "true" }, { "id": "F6YRI6", "map_id": "F6YRI6", "name": "gad1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000012900", "map_id": "ENSXETT00000012900", "name": "gad1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10320192", "map_id": "none", "name": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10320189", "map_id": "Q6DIV6", "name": "slc32a1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane", "complex": "false" }, { "id": "ENSXETT00000054324", "map_id": "ENSXETT00000054324", "name": "slc32a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316559", "map_id": "none", "name": "L-Glutamine transport into neurons", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_212615", "map_id": "CHEBI:58359", "name": "L-Gln", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_29472", "map_id": "CHEBI:58359", "name": "L-Gln", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10316556", "map_id": "Q5XH90", "name": "slc38a2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000014662", "map_id": "ENSXETG00000014662", "name": "slc38a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316154", "map_id": "none", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10316149", "map_id": "none", "name": "Empty Glutamate Synaptic Vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q28H43", "map_id": "Q28H43", "name": "rab3a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000090296", "map_id": "ENSXETT00000090296", "name": "rab3a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q05B21", "map_id": "Q05B21", "name": "slc17a7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000082042", "map_id": "ENSXETT00000082042", "name": "slc17a7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q031", "map_id": "A0A6I8Q031", "name": "vamp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000008255", "map_id": "ENSXETG00000008255", "name": "vamp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10316151", "map_id": "none", "name": "Glutamate loaded synaptic vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_210382", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10316115", "map_id": "none", "name": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10316108", "map_id": "A0A6I8QSR9", "name": "slc1a1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000011685", "map_id": "ENSXETG00000011685", "name": "slc1a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10316113", "map_id": "B2GUF7", "name": "arl6ip5", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000102749", "map_id": "ENSXETT00000102749", "name": "arl6ip5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316133", "map_id": "none", "name": "Ca2+ influx through voltage gated Ca2+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10316130", "map_id": "none", "name": "calcium channel multimer of P/Q type VGCC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PYQ9", "map_id": "A0A6I8PYQ9", "name": "cacnb4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000021694", "map_id": "ENSXETG00000021694", "name": "cacnb4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SXZ7", "map_id": "A0A6I8SXZ7", "name": "cacna1a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000005585", "map_id": "ENSXETG00000005585", "name": "cacna1a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337901", "map_id": "none", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9634838", "map_id": "none", "name": "ACHEIs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10316781", "map_id": "none", "name": "Homologues of ACHE", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10316784", "map_id": "none", "name": "ACHE:ACHEIs", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10317200", "map_id": "none", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_380598", "map_id": "CHEBI:50157", "name": "HIALD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_380593", "map_id": "CHEBI:27823", "name": "HIAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10317171", "map_id": "none", "name": "COMT transfers Met to DOPAC to form HVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9677997", "map_id": "CHEBI:41941", "name": "DOPAC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9677992", "map_id": "CHEBI:545959", "name": "HVA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_174369", "map_id": "CHEBI:17230", "name": "HCYS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10317160", "map_id": "A9UMU1", "name": "LOC100135405", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10317165", "map_id": "none", "name": "COMT transfers Met to DA to form 3MT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8954997", "map_id": "CHEBI:1582", "name": "3MT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10317163", "map_id": "none", "name": "COMT:COMT inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A9UMU1", "map_id": "A9UMU1", "name": "LOC100135405", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336969", "map_id": "none", "name": "LRTOMT transfers Met to DA, forming 3MT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10336966", "map_id": "A0A6I8RH01", "name": "LOC100490284", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000039768", "map_id": "ENSXETG00000039768", "name": "LOC100490284", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10338104", "map_id": "none", "name": "COMT binds COMT Inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9679778", "map_id": "none", "name": "COMT inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10316786", "map_id": "none", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_372533", "map_id": "CHEBI:15355", "name": "AcCho", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_1524044", "map_id": "CHEBI:30089", "name": "acetate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_264638", "map_id": "CHEBI:15354", "name": "Cho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10316552", "map_id": "none", "name": "Glutamine transport from astrocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10316549", "map_id": "A0A6I8Q5F6", "name": "slc38a1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000041195", "map_id": "ENSXETG00000041195", "name": "slc38a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311522", "map_id": "none", "name": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31633", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311519", "map_id": "none", "name": "GLUL decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F6VAG8", "map_id": "F6VAG8", "name": "glul-like.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000027374", "map_id": "ENSXETT00000027374", "name": "glul-like.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10338094", "map_id": "none", "name": "C-ter TLR7 dimer binds HCQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10338090", "map_id": "none", "name": "C-ter TLR7 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "F7EDI8", "map_id": "F7EDI8", "name": "tlr9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000013094", "map_id": "ENSXETT00000013094", "name": "tlr9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9678628", "map_id": "none", "name": "HCQ", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10338092", "map_id": "none", "name": "C-ter TLR7 dimer:HCQ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10313351", "map_id": "none", "name": "NFkB complex is transported from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10313343", "map_id": "none", "name": "NFKB1(1-433), NFKB2(1-454):RELA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SZP6", "map_id": "A0A6I8SZP6", "name": "nfkb1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000021325", "map_id": "ENSXETG00000021325", "name": "nfkb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PS73", "map_id": "A0A6I8PS73", "name": "rela", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000026173", "map_id": "ENSXETG00000026173", "name": "rela", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10313349", "map_id": "none", "name": "NFkB Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10312161", "map_id": "none", "name": "Formation of RAD52 heptameric ring structure complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10312157", "map_id": "A0A6I8RDE5", "name": "rad52", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000009413", "map_id": "ENSXETG00000009413", "name": "rad52", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312159", "map_id": "none", "name": "RAD52 heptamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8RDE5", "map_id": "A0A6I8RDE5", "name": "rad52", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337038", "map_id": "none", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10317378", "map_id": "none", "name": "PAK2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8T271", "map_id": "A0A6I8T271", "name": "pak2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000011808", "map_id": "ENSXETG00000011808", "name": "pak2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312717", "map_id": "none", "name": "RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q6GL60", "map_id": "Q6GL60", "name": "rac1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000092508", "map_id": "ENSXETT00000092508", "name": "rac1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29438", "map_id": "CHEBI:15996", "name": "GTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10317376", "map_id": "A0A6I8T271", "name": "pak2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10317380", "map_id": "none", "name": "PAK1,2,3:CDC42:GTP, RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10330050", "map_id": "none", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10329598", "map_id": "A0A6I8T271", "name": "phospho-pak2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10314369", "map_id": "none", "name": "PI3K produces PIP3 and other phosphatidyl inositides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane" }, { "id": "species_179856", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_179838", "map_id": "CHEBI:16618", "name": "PI(3,4,5)P3", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10314366", "map_id": "none", "name": "Phospho-IRS1/2:PI3K(p85:p110)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8RAF1", "map_id": "A0A6I8RAF1", "name": "phospho-LOC100498409", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039550", "map_id": "ENSXETG00000039550", "name": "phospho-LOC100498409", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q186", "map_id": "A0A6I8Q186", "name": "pik3r2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000012933", "map_id": "ENSXETG00000012933", "name": "pik3r2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RUB1", "map_id": "A0A6I8RUB1", "name": "pik3ca", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000007252", "map_id": "ENSXETG00000007252", "name": "pik3ca", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337673", "map_id": "none", "name": "NTRK3 dimers trans-autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10337661", "map_id": "none", "name": "NTF3:NTRK3 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F6VUP1", "map_id": "F6VUP1", "name": "NTF3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000036251", "map_id": "ENSXETT00000036251", "name": "NTF3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8T1S6", "map_id": "A0A6I8T1S6", "name": "ntrk3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033787", "map_id": "ENSXETG00000033787", "name": "ntrk3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337670", "map_id": "none", "name": "NTF3:p-5Y-NTRK3 homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10334500", "map_id": "none", "name": "DHCR7 reduces 7-dehydroCHOL to CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6807057", "map_id": "CHEBI:17759", "name": "7-dehydroCHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10314334", "map_id": "Q6P4M0", "name": "dhcr7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000008945", "map_id": "ENSXETG00000008945", "name": "dhcr7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334502", "map_id": "none", "name": "DHCR24 reduces ZYMOL to ZYMSTNL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_194691", "map_id": "CHEBI:18252", "name": "ZYMOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_6807048", "map_id": "CHEBI:16608", "name": "ZYMSTNL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10314341", "map_id": "A0A6I8Q4J3", "name": "dhcr24", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000020010", "map_id": "ENSXETG00000020010", "name": "dhcr24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334498", "map_id": "none", "name": "SC5D desaturates LTHSOL to 7-dehydroCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6807054", "map_id": "CHEBI:17168", "name": "LTHSOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10314319", "map_id": "A0A6I8SXZ8", "name": "sc5d", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000040073", "map_id": "ENSXETG00000040073", "name": "sc5d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10332459", "map_id": "none", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10332455", "map_id": "B5DE93", "name": "cdk12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000023695", "map_id": "ENSXETG00000023695", "name": "cdk12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312628", "map_id": "F7CLE9", "name": "ssbp2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000049621", "map_id": "ENSXETT00000049621", "name": "ssbp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10332457", "map_id": "none", "name": "CCNK:CDK12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "F7CLE9", "map_id": "F7CLE9", "name": "ssbp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B5DE93", "map_id": "B5DE93", "name": "cdk12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10332465", "map_id": "none", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10332461", "map_id": "B5DE93", "name": "cdk12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10332463", "map_id": "none", "name": "CCNK:CDK13", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10314021", "map_id": "none", "name": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10313994", "map_id": "A0A6I8SFF7", "name": "CDKN1B", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000038125", "map_id": "ENSXETG00000038125", "name": "phospho-p-S10 CDKN1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10313486", "map_id": "none", "name": "CCNA:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10314013", "map_id": "none", "name": "Cyclin A:Cdk2:p21/p27 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8SFF7", "map_id": "A0A6I8SFF7", "name": "phospho-p-S10 CDKN1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10330057", "map_id": "none", "name": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30533", "map_id": "CHEBI:28602", "name": "D-Fructose 2,6-bisphosphate", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29512", "map_id": "CHEBI:57634", "name": "Fru(6)P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10330054", "map_id": "B1WAX6", "name": "tigar", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000005971", "map_id": "ENSXETG00000005971", "name": "tigar", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10330082", "map_id": "none", "name": "DDIT4 binds 14-3-3 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312804", "map_id": "none", "name": "14-3-3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6P4Z5", "map_id": "Q6P4Z5", "name": "ywhaz", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000013608", "map_id": "ENSXETT00000013608", "name": "ywhaz", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330078", "map_id": "Q6P4J6", "name": "ddit4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000083124", "map_id": "ENSXETT00000083124", "name": "ddit4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330080", "map_id": "none", "name": "DDIT4:14-3-3 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6P4J6", "map_id": "Q6P4J6", "name": "ddit4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10333927", "map_id": "none", "name": "STEAP3 binds BNIP3L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10333923", "map_id": "F7AAW4", "name": "bnip3l", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "ENSXETT00000022422", "map_id": "ENSXETT00000022422", "name": "bnip3l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320592", "map_id": "F6YGT5", "name": "grm2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "ENSXETT00000016208", "map_id": "ENSXETT00000016208", "name": "grm2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10333925", "map_id": "none", "name": "STEAP3:BNIP3L", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "F6YGT5", "map_id": "F6YGT5", "name": "grm2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7AAW4", "map_id": "F7AAW4", "name": "bnip3l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10333915", "map_id": "none", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10333911", "map_id": "A0A6I8PT43", "name": "phospho-pidd1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000033984", "map_id": "ENSXETG00000033984", "name": "phospho-pidd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10333913", "map_id": "A0A6I8PT43", "name": "phospho-pidd1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10320843", "map_id": "none", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_936706", "map_id": "CHEBI:15811", "name": "O-P-Ser", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_200736", "map_id": "CHEBI:33384", "name": "L-Ser", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10320840", "map_id": "none", "name": "PSPH:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8R2I0", "map_id": "A0A6I8R2I0", "name": "psph", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000041151", "map_id": "ENSXETG00000041151", "name": "psph", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335757", "map_id": "none", "name": "ARRB bind GPCRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10335751", "map_id": "none", "name": "Homologues of ARRB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F6SUX3", "map_id": "F6SUX3", "name": "arr3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000050169", "map_id": "ENSXETT00000050169", "name": "arr3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6SKI7", "map_id": "F6SKI7", "name": "sag", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000021189", "map_id": "ENSXETT00000021189", "name": "sag", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335753", "map_id": "none", "name": "ARRB-binding GPCRs", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10335755", "map_id": "none", "name": "ARRB:ARRB-binding GPCRs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10338108", "map_id": "none", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9648300", "map_id": "none", "name": "chlorpromazine", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10335334", "map_id": "none", "name": "AP-2 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8RNH9", "map_id": "A0A6I8RNH9", "name": "ap2b1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000013480", "map_id": "ENSXETG00000013480", "name": "ap2b1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PJR6", "map_id": "A0A6I8PJR6", "name": "ap2a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000009033", "map_id": "ENSXETG00000009033", "name": "ap2a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6P856", "map_id": "Q6P856", "name": "ap2m1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000017276", "map_id": "ENSXETG00000017276", "name": "ap2m1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335769", "map_id": "none", "name": "AP2:chlorpromazine", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10335647", "map_id": "none", "name": "STON2 binds SYT proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10335633", "map_id": "none", "name": "SYT9 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PYV5", "map_id": "A0A6I8PYV5", "name": "syt9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034334", "map_id": "ENSXETG00000034334", "name": "syt9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335643", "map_id": "none", "name": "STON2,1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SQ61", "map_id": "A0A6I8SQ61", "name": "STON2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038939", "map_id": "ENSXETG00000038939", "name": "STON2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335645", "map_id": "none", "name": "STON2,1:SYT dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10335771", "map_id": "none", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10335765", "map_id": "none", "name": "AP-2 cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F7BD23", "map_id": "F7BD23", "name": "CD4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000017485", "map_id": "ENSXETT00000017485", "name": "CD4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QYZ2", "map_id": "A0A6I8QYZ2", "name": "tgoln2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039705", "map_id": "ENSXETG00000039705", "name": "tgoln2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QZE2", "map_id": "A0A6I8QZE2", "name": "TFRC(1-760)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040690", "map_id": "ENSXETG00000040690", "name": "TFRC(1-760)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_912516", "map_id": "CHEBI:29034", "name": "Fe3+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "Q501K5", "map_id": "Q501K5", "name": "tf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000011814", "map_id": "ENSXETG00000011814", "name": "tf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QXB4", "map_id": "A0A6I8QXB4", "name": "igf2r", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000021138", "map_id": "ENSXETG00000021138", "name": "igf2r", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335767", "map_id": "none", "name": "AP-2:cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10335824", "map_id": "none", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10335810", "map_id": "A0A6I8Q031", "name": "vamp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10335820", "map_id": "none", "name": "PICALMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8Q6S5", "map_id": "A0A6I8Q6S5", "name": "picalm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000032563", "map_id": "ENSXETG00000032563", "name": "picalm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335822", "map_id": "none", "name": "PICALM:VAMP2,3,8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10335841", "map_id": "none", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_392417", "map_id": "CHEBI:17526", "name": "PI4P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10323969", "map_id": "F7CC78", "name": "pip5k1a", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000042073", "map_id": "ENSXETT00000042073", "name": "pip5k1a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327264", "map_id": "none", "name": "STING ubiquitination by TRIM32 or TRIM56", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10324513", "map_id": "none", "name": "STING:TRIM32/TRIM56", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A6I8SBS8", "map_id": "A0A6I8SBS8", "name": "LOC100488610", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039978", "map_id": "ENSXETG00000039978", "name": "LOC100488610", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8E5V9", "map_id": "A8E5V9", "name": "sting1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000016088", "map_id": "ENSXETG00000016088", "name": "sting1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10327258", "map_id": "A8E5V9", "name": "sting1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10324511", "map_id": "A0A6I8SBS8", "name": "LOC100488610", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10324515", "map_id": "none", "name": "STING binds TRIM32 or TRIM56 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10324507", "map_id": "A8E5V9", "name": "sting1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10316740", "map_id": "none", "name": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352091", "map_id": "none", "name": "ligands of SLC38A2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_29432", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_379717", "map_id": "CHEBI:60039", "name": "L-Pro", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "CHEBI:57926", "map_id": "CHEBI:57926", "name": "CHEBI:57926", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:58048", "map_id": "CHEBI:58048", "name": "CHEBI:58048", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29588", "map_id": "CHEBI:57427", "name": "L-Leu", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_352088", "map_id": "none", "name": "ligands of SLC38A2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10316756", "map_id": "none", "name": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352229", "map_id": "none", "name": "ligands of SLC7A5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_29500", "map_id": "CHEBI:57912", "name": "L-Trp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:58045", "map_id": "CHEBI:58045", "name": "CHEBI:58045", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29612", "map_id": "CHEBI:32513", "name": "L-His", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:58315", "map_id": "CHEBI:58315", "name": "CHEBI:58315", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_351993", "map_id": "CHEBI:58095", "name": "L-Phe", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "CHEBI:57762", "map_id": "CHEBI:57762", "name": "CHEBI:57762", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_352227", "map_id": "none", "name": "ligands of SLC7A5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10316753", "map_id": "none", "name": "SLC7A5:SLC3A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "B5DDZ9", "map_id": "B5DDZ9", "name": "slc7a5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000061667", "map_id": "ENSXETT00000061667", "name": "slc7a5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6YKM8", "map_id": "F6YKM8", "name": "slc3a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000042158", "map_id": "ENSXETT00000042158", "name": "slc3a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316743", "map_id": "none", "name": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352123", "map_id": "none", "name": "ligands of SLC38A1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_352105", "map_id": "none", "name": "ligands of SLC38A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10317169", "map_id": "none", "name": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_351964", "map_id": "CHEBI:57427", "name": "L-Leu", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351977", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10317013", "map_id": "none", "name": "SLC7A6:SLC3A2 heterodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q28I80", "map_id": "Q28I80", "name": "slc7a6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000014625", "map_id": "ENSXETT00000014625", "name": "slc7a6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316738", "map_id": "none", "name": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352101", "map_id": "none", "name": "ligands of SLC43A1 and SLC43A2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_352114", "map_id": "none", "name": "ligands of SLC43A1 and SLC43A2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10316735", "map_id": "A4IHK6", "name": "slc43a2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000022279", "map_id": "ENSXETG00000022279", "name": "slc43a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317920", "map_id": "none", "name": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10317917", "map_id": "A0A6I8QPK3", "name": "slc24a4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000010290", "map_id": "ENSXETG00000010290", "name": "slc24a4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335224", "map_id": "none", "name": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2162252", "map_id": "CHEBI:16680", "name": "AdoHcy", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162265", "map_id": "CHEBI:15414", "name": "AdoMet", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10335221", "map_id": "Q6GLA2", "name": "slc25a26", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "ENSXETG00000026858", "map_id": "ENSXETG00000026858", "name": "slc25a26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317940", "map_id": "none", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10317937", "map_id": "none", "name": "SLC9A1-5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PNM9", "map_id": "A0A6I8PNM9", "name": "slc9a4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033166", "map_id": "ENSXETG00000033166", "name": "slc9a4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S3I9", "map_id": "A0A6I8S3I9", "name": "slc9a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040616", "map_id": "ENSXETG00000040616", "name": "slc9a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317927", "map_id": "none", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_425999", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_173031", "compartment_display": "late endosome lumen", "complex": "false" }, { "id": "species_425977", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_173031", "compartment_display": "late endosome lumen", "complex": "false" }, { "id": "species_10317924", "map_id": "F6SMT4", "name": "ocel1.2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "ENSXETT00000029654", "map_id": "ENSXETT00000029654", "name": "ocel1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318058", "map_id": "none", "name": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428027", "map_id": "none", "name": "L-Glu,L-Asp,D-Asp", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_29448", "map_id": "CHEBI:29991", "name": "L-Asp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6810061", "map_id": "CHEBI:17364", "name": "D-Asp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_427997", "map_id": "none", "name": "L-Glu,L-Asp,D-Asp", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10318141", "map_id": "none", "name": "SLC5A8 transports monocarboxylates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429739", "map_id": "none", "name": "monocarboxylates transported by SLC5A8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_29398", "map_id": "CHEBI:15361", "name": "PYR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_373863", "map_id": "CHEBI:422", "name": "LACT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "CHEBI:32544", "map_id": "CHEBI:32544", "name": "CHEBI:32544", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29416", "map_id": "CHEBI:15366", "name": "CH3COO-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:30768", "map_id": "CHEBI:30768", "name": "CHEBI:30768", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_429748", "map_id": "none", "name": "monocarboxylates transported by SLC5A8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:15940", "map_id": "CHEBI:15940", "name": "CHEBI:15940", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318138", "map_id": "A0A6I8SA52", "name": "LOC100488353", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000031274", "map_id": "ENSXETG00000031274", "name": "LOC100488353", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318063", "map_id": "none", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane" }, { "id": "species_428548", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20600", "compartment_display": "synaptic vesicle", "complex": "false" }, { "id": "species_428614", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20600", "compartment_display": "synaptic vesicle", "complex": "false" }, { "id": "species_10318060", "map_id": "Q05B21", "name": "slc17a7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane", "complex": "false" }, { "id": "reaction_10318144", "map_id": "none", "name": "Passive I- efflux mediated by SMCT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_209785", "map_id": "CHEBI:16382", "name": "I-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_209818", "map_id": "CHEBI:16382", "name": "I-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10318084", "map_id": "none", "name": "Vesicular inhibitory amino acid transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane" }, { "id": "species_428592", "map_id": "none", "name": "Inhibitory amino acids", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_428632", "map_id": "none", "name": "Inhibitory amino acids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20600", "compartment_display": "synaptic vesicle", "complex": "true" }, { "id": "species_10318081", "map_id": "Q6DIV6", "name": "slc32a1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane", "complex": "false" }, { "id": "reaction_10318014", "map_id": "none", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10318011", "map_id": "A4IIF2", "name": "slc26a9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000005947", "map_id": "ENSXETG00000005947", "name": "slc26a9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335952", "map_id": "none", "name": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8876310", "map_id": "none", "name": "LACT, PYR, NCA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_8876304", "map_id": "none", "name": "LACT, PYR, NCA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10335949", "map_id": "A0A6I8R6K5", "name": "slc5a12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000025601", "map_id": "ENSXETG00000025601", "name": "slc5a12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318034", "map_id": "none", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_111627", "map_id": "CHEBI:17544", "name": "HCO3-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_425425", "map_id": "CHEBI:17544", "name": "HCO3-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10318031", "map_id": "A0A6I8SFZ9", "name": "slc26a6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000016188", "map_id": "ENSXETG00000016188", "name": "slc26a6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318027", "map_id": "none", "name": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_109277", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10318024", "map_id": "none", "name": "Type III Na+/Pi cotransporters", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q28E01", "map_id": "Q28E01", "name": "slc20a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000009532", "map_id": "ENSXETG00000009532", "name": "slc20a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5BL44", "map_id": "Q5BL44", "name": "slc20a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000041138", "map_id": "ENSXETT00000041138", "name": "slc20a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312261", "map_id": "none", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10312257", "map_id": "Q6DIE2", "name": "ncbp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000010179", "map_id": "ENSXETG00000010179", "name": "ncbp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312253", "map_id": "Q6DES0", "name": "ncbp2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000041997", "map_id": "ENSXETT00000041997", "name": "ncbp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312259", "map_id": "none", "name": "Cap Binding Complex (CBC)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q6DES0", "map_id": "Q6DES0", "name": "ncbp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6DIE2", "map_id": "Q6DIE2", "name": "ncbp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318606", "map_id": "none", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_450523", "map_id": "none", "name": "mRNA Transcript Targeted by BRF1", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10318588", "map_id": "A0A6I8SGT0", "name": "XB5726464", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000030723", "map_id": "ENSXETG00000030723", "name": "phospho-XB5726464", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318590", "map_id": "none", "name": "BRF1:mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SGT0", "map_id": "A0A6I8SGT0", "name": "phospho-XB5726464", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318952", "map_id": "none", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312800", "map_id": "Q5XGC8", "name": "ywhab", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10318596", "map_id": "none", "name": "Phosphorylated BRF1 (Ser54, Ser92, Ser203):mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10318950", "map_id": "none", "name": "Phosphorylated BRF1 (Ser54, Ser92, Ser203):mRNA:14-3-3 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10318586", "map_id": "none", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10318582", "map_id": "none", "name": "Phosphorylated BRF1 (Ser92, Ser203):mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10318584", "map_id": "none", "name": "Phosphorylated BRF1 (Ser92, Ser203):mRNA:14-3-3 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10318604", "map_id": "none", "name": "HuR binds mRNAs in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10318600", "map_id": "Q6GLB5", "name": "elavl1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000008752", "map_id": "ENSXETG00000008752", "name": "phospho-elavl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_450613", "map_id": "none", "name": "mRNA Transcript Targeted by HuR with Unknown Phosphorylation", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10318602", "map_id": "none", "name": "HuR with Unknown Phosphorylation: mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q6GLB5", "map_id": "Q6GLB5", "name": "phospho-elavl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10319007", "map_id": "none", "name": "p-S318,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10318610", "map_id": "Q6GLB5", "name": "phospho-elavl1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_517622", "map_id": "none", "name": "mRNA Transcript Targeted by HuR Phosphorylated on Ser221 and Ser318", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10319005", "map_id": "none", "name": "HuR with phosphoserine221 and phosphoserine318:mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10319003", "map_id": "none", "name": "p-S158,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_450605", "map_id": "none", "name": "mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318.", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10318613", "map_id": "Q6GLB5", "name": "phospho-elavl1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10319001", "map_id": "none", "name": "HuR with phosphoserine221 and phosphoserine158:mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10314047", "map_id": "none", "name": "Digestion of linear starch (amylose) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_189075", "map_id": "none", "name": "starch (amylose)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_70113", "map_id": "CHEBI:17925", "name": "Glc", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_191103", "map_id": "CHEBI:27931", "name": "maltotriose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_188986", "map_id": "CHEBI:17306", "name": "Mal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10314044", "map_id": "A0A6I8STN7", "name": "amy2a", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000010847", "map_id": "ENSXETG00000010847", "name": "amy2a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314056", "map_id": "none", "name": "lactose + H2O => D-glucose + D-galactose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_188973", "map_id": "CHEBI:17716", "name": "Lac", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_70115", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_188995", "map_id": "CHEBI:17118", "name": "Gal", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10314053", "map_id": "none", "name": "LCT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8SYH9", "map_id": "A0A6I8SYH9", "name": "lct.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000025031", "map_id": "ENSXETG00000025031", "name": "lct.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314145", "map_id": "none", "name": "Digestion of branched starch (amylopectin) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_189071", "map_id": "none", "name": "starch (amylopectin)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_189108", "map_id": "CHEBI:28912", "name": "limit dextrins", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10328964", "map_id": "none", "name": "PIAS3 SUMOylates RELA with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10327222", "map_id": "none", "name": "SUMO3:UBE2I", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q6DK72", "map_id": "Q6DK72", "name": "sumo3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000062462", "map_id": "ENSXETT00000062462", "name": "sumo3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28CQ4", "map_id": "Q28CQ4", "name": "ube2i", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000054232", "map_id": "ENSXETT00000054232", "name": "ube2i", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328953", "map_id": "none", "name": "RELA:RELA:DNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10328962", "map_id": "none", "name": "SUMO3-RELA:SUMO3-RELA:DNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10327128", "map_id": "Q28CQ4", "name": "ube2i", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10328492", "map_id": "A0A6I8S7F8", "name": "pias3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000018642", "map_id": "ENSXETG00000018642", "name": "pias3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334705", "map_id": "none", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_429785", "map_id": "CHEBI:16110", "name": "PC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_6814303", "map_id": "CHEBI:35366", "name": "fatty acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8848483", "map_id": "CHEBI:17504", "name": "2-lysophosphatidylcholine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10318101", "map_id": "B1WAZ6", "name": "pla2g4a", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000066288", "map_id": "ENSXETT00000066288", "name": "phospho-pla2g4a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335199", "map_id": "none", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10335194", "map_id": "none", "name": "RAB7A:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "F7A377", "map_id": "F7A377", "name": "RAB7A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000029250", "map_id": "ENSXETT00000029250", "name": "RAB7A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335196", "map_id": "none", "name": "RAB7A:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_29420", "map_id": "CHEBI:17552", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10335189", "map_id": "none", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10335180", "map_id": "none", "name": "RAB35:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "Q6P7Z7", "map_id": "Q6P7Z7", "name": "rab35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000056541", "map_id": "ENSXETT00000056541", "name": "rab35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335182", "map_id": "none", "name": "RAB35:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10335187", "map_id": "Q08CX5", "name": "tbc1d24", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000043751", "map_id": "ENSXETT00000043751", "name": "tbc1d24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335207", "map_id": "none", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10335205", "map_id": "none", "name": "RAB7:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10335984", "map_id": "none", "name": "p-ULK1 phosphorylates DENND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10335969", "map_id": "F6W6Z5", "name": "DENND3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000054527", "map_id": "ENSXETT00000054527", "name": "phospho-p-S472,S490-DENND3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335973", "map_id": "F6W6Z5", "name": "phospho-p-S472,S490-DENND3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10335981", "map_id": "A0A6I8QPJ0", "name": "phospho-ulk1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000002028", "map_id": "ENSXETG00000002028", "name": "ulk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318634", "map_id": "none", "name": "Microtubule-independent trafficking of connexons to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10318628", "map_id": "none", "name": "Connexin 26 Connexon", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_190626", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment", "complex": "true" }, { "id": "Q28ED4", "map_id": "Q28ED4", "name": "gjb2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000055228", "map_id": "ENSXETT00000055228", "name": "gjb2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318632", "map_id": "none", "name": "Connexon 26", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10314143", "map_id": "none", "name": "Connexin oligomerization in endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10314138", "map_id": "Q6NVT8", "name": "gjb1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETT00000055497", "map_id": "ENSXETT00000055497", "name": "gjb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10314140", "map_id": "none", "name": "Connexin 32 connexon", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q6NVT8", "map_id": "Q6NVT8", "name": "gjb1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335934", "map_id": "none", "name": "ACBD3 binds GOLGB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10335924", "map_id": "F6WGE2", "name": "acbd3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETT00000048980", "map_id": "ENSXETT00000048980", "name": "acbd3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335930", "map_id": "none", "name": "GOLGB1 homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "A0A6I8PMP5", "map_id": "A0A6I8PMP5", "name": "golgb1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033340", "map_id": "ENSXETG00000033340", "name": "golgb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335932", "map_id": "none", "name": "ACBD3:GOLGB1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "F6WGE2", "map_id": "F6WGE2", "name": "acbd3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326647", "map_id": "none", "name": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane" }, { "id": "species_10326631", "map_id": "none", "name": "Platelet glycoprotein IV:Ligand", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_426658", "map_id": "CHEBI:16749", "name": "PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "CHEBI:28640", "map_id": "CHEBI:28640", "name": "CHEBI:28640", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2186967", "map_id": "CHEBI:60156", "name": "oxidized phospholipids", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_30495", "map_id": "CHEBI:15904", "name": "LCFA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:37671", "map_id": "CHEBI:37671", "name": "CHEBI:37671", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PU04", "map_id": "A0A6I8PU04", "name": "XB5857568", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033423", "map_id": "ENSXETG00000033423", "name": "XB5857568", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_171126", "map_id": "CHEBI:17855", "name": "TAGs", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_171142", "map_id": "CHEBI:16247", "name": "PL", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:60479", "map_id": "CHEBI:60479", "name": "CHEBI:60479", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:64009", "map_id": "CHEBI:64009", "name": "CHEBI:64009", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:64294", "map_id": "CHEBI:64294", "name": "CHEBI:64294", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RKY6", "map_id": "A0A6I8RKY6", "name": "apob", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000026768", "map_id": "ENSXETG00000026768", "name": "apob", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:24654", "map_id": "CHEBI:24654", "name": "CHEBI:24654", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S279", "map_id": "A0A6I8S279", "name": "CD36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037724", "map_id": "ENSXETG00000037724", "name": "CD36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326645", "map_id": "none", "name": "Platelet glycoprotein IV:Ligand", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10318182", "map_id": "none", "name": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_400452", "map_id": "CHEBI:15756", "name": "PALM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10318179", "map_id": "A0A6I8S279", "name": "4xPalmC-CD36", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10329322", "map_id": "none", "name": "DAG and Ca+2 bind to PKC and tether it to membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10329318", "map_id": "A8KBH6", "name": "phospho-prkcb", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000017294", "map_id": "ENSXETG00000017294", "name": "prkcb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5221124", "map_id": "CHEBI:17815", "name": "DAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_29496", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10329320", "map_id": "none", "name": "DAG:active PKC:Ca+2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "species_114519", "map_id": "CHEBI:17815", "name": "DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "A8KBH6", "map_id": "A8KBH6", "name": "prkcb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326334", "map_id": "none", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10326327", "map_id": "none", "name": "PHF8:Nucleosome with H3K4me2/3:H4K20me1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_435347", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "A0A6I8RKR7", "map_id": "A0A6I8RKR7", "name": "HIST1H4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035354", "map_id": "ENSXETG00000035354", "name": "HIST1H4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113671", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113685", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_29478", "map_id": "CHEBI:16842", "name": "CH2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10326331", "map_id": "none", "name": "PHF8:Nucleosome with H3K4me2/3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_159942", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_159939", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10326658", "map_id": "none", "name": "SETD8 monomethylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_77087", "map_id": "CHEBI:15414", "name": "AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_77502", "map_id": "CHEBI:16680", "name": "AdoHcy", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10326655", "map_id": "Q0V9E9", "name": "kmt5a", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000012803", "map_id": "ENSXETT00000012803", "name": "kmt5a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326218", "map_id": "none", "name": "MASTL (GWL) phosphorylates ARPP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10326205", "map_id": "Q28GU6", "name": "arpp19", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000027097", "map_id": "ENSXETG00000027097", "name": "phospho-arpp19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326208", "map_id": "Q28GU6", "name": "phospho-arpp19", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10326215", "map_id": "B1WAR9", "name": "phospho-mastl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000018741", "map_id": "ENSXETG00000018741", "name": "phospho-mastl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326837", "map_id": "none", "name": "MASTL phosphorylates ENSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10326832", "map_id": "Q6NVR1", "name": "ensa", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000056121", "map_id": "ENSXETT00000056121", "name": "phospho-ensa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326835", "map_id": "Q6NVR1", "name": "phospho-ensa", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10337987", "map_id": "none", "name": "EML4 trimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337983", "map_id": "Q6DIP5", "name": "eml4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000006002", "map_id": "ENSXETG00000006002", "name": "eml4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337985", "map_id": "none", "name": "EML4 homotrimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6DIP5", "map_id": "Q6DIP5", "name": "eml4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10313138", "map_id": "none", "name": "Down Regulation of Emi1 through Phosphorylation of Emi1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10313127", "map_id": "Q28GK6", "name": "fbxo5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000018545", "map_id": "ENSXETG00000018545", "name": "phospho-fbxo5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10313130", "map_id": "Q28GK6", "name": "phospho-fbxo5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10337822", "map_id": "none", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9624879", "map_id": "none", "name": "Nuclear envelope vesicle", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10337818", "map_id": "none", "name": "RAN:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6GL85", "map_id": "Q6GL85", "name": "ran", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000027832", "map_id": "ENSXETG00000027832", "name": "ran", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337820", "map_id": "none", "name": "RAN:GTP:Nuclear envelope vesicles", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10313996", "map_id": "none", "name": "Translocation of p27 to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10313992", "map_id": "A0A6I8SFF7", "name": "CDKN1B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10314011", "map_id": "none", "name": "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10314003", "map_id": "none", "name": "Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10314008", "map_id": "none", "name": "Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10313473", "map_id": "none", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10311363", "map_id": "F6T0J1", "name": "cdk19", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10313428", "map_id": "none", "name": "CCNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10313471", "map_id": "none", "name": "CCNA:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10313488", "map_id": "none", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_10314032", "map_id": "none", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10311391", "map_id": "A0A6I8QXT8", "name": "phospho-rb1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000031493", "map_id": "ENSXETG00000031493", "name": "phospho-rb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312634", "map_id": "A0A6I8QXT8", "name": "phospho-rb1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10314018", "map_id": "none", "name": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10314015", "map_id": "none", "name": "Cyclin A:Cdk2:phospho-p27/p21 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10311361", "map_id": "none", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10311355", "map_id": "none", "name": "MCM2-7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q561P5", "map_id": "Q561P5", "name": "mcm5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000000253", "map_id": "ENSXETG00000000253", "name": "mcm5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6GL41", "map_id": "Q6GL41", "name": "mcm4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000004854", "map_id": "ENSXETG00000004854", "name": "mcm4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6DIH3", "map_id": "Q6DIH3", "name": "mcm2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000002059", "map_id": "ENSXETG00000002059", "name": "mcm2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28BS0", "map_id": "Q28BS0", "name": "zmcm3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000021701", "map_id": "ENSXETG00000021701", "name": "zmcm3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6NX31", "map_id": "Q6NX31", "name": "mcm7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000074596", "map_id": "ENSXETT00000074596", "name": "mcm7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6P1V8", "map_id": "Q6P1V8", "name": "zmcm6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000014891", "map_id": "ENSXETG00000014891", "name": "zmcm6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10311333", "map_id": "Q28BS0", "name": "zmcm3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10311353", "map_id": "Q6DIH3", "name": "mcm2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10311359", "map_id": "none", "name": "Mcm4,6,7 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10311341", "map_id": "Q561P5", "name": "mcm5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10338031", "map_id": "none", "name": "RB1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10338029", "map_id": "A0A6I8QXT8", "name": "rb1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311367", "map_id": "A0A6I8QXT8", "name": "rb1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10322470", "map_id": "none", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10322466", "map_id": "F6UBS5", "name": "dcstamp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000008804", "map_id": "ENSXETT00000008804", "name": "dcstamp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10322468", "map_id": "none", "name": "RBL1:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "F6UBS5", "map_id": "F6UBS5", "name": "dcstamp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326109", "map_id": "none", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2142836", "map_id": "CHEBI:63998", "name": "19-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10326106", "map_id": "none", "name": "CYP(2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A6I8SJ30", "map_id": "A0A6I8SJ30", "name": "cyp1b1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6W5W2", "map_id": "F6W5W2", "name": "cyp2r1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326121", "map_id": "none", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2142780", "map_id": "CHEBI:34306", "name": "20-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10326118", "map_id": "none", "name": "CYP(3)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10326104", "map_id": "none", "name": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2161639", "map_id": "none", "name": "16/17/18-HETE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:63995", "map_id": "CHEBI:63995", "name": "CHEBI:63995", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:63994", "map_id": "CHEBI:63994", "name": "CHEBI:63994", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:63579", "map_id": "CHEBI:63579", "name": "CHEBI:63579", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326101", "map_id": "none", "name": "CYP(1)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10316618", "map_id": "none", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10316611", "map_id": "A0A6I8RXS2", "name": "phospho-cop1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000009192", "map_id": "ENSXETG00000009192", "name": "phospho-cop1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10316615", "map_id": "none", "name": "ubiquitinated phospho-COP1(ser-387)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8RXS2", "map_id": "A0A6I8RXS2", "name": "phospho-cop1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316613", "map_id": "none", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10316609", "map_id": "A0A6I8RXS2", "name": "phospho-cop1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10320461", "map_id": "none", "name": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_914003", "map_id": "CHEBI:16264", "name": "UDP-GlcNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10320438", "map_id": "none", "name": "Core 1 mucins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "A0A6I8R3H8", "map_id": "A0A6I8R3H8", "name": "Core 8 (MUC15)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039522", "map_id": "ENSXETG00000039522", "name": "Core 8 (MUC15)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QYJ7", "map_id": "A0A6I8QYJ7", "name": "Core 8 (MUC3A)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037294", "map_id": "ENSXETG00000037294", "name": "Core 8 (MUC3A)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QTA8", "map_id": "A0A6I8QTA8", "name": "muc6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000018869", "map_id": "ENSXETG00000018869", "name": "muc6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RWC5", "map_id": "A0A6I8RWC5", "name": "muc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036774", "map_id": "ENSXETG00000036774", "name": "muc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320454", "map_id": "none", "name": "Core 2 mucins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_205687", "map_id": "CHEBI:17659", "name": "UDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10320458", "map_id": "A0A6I8PZN3", "name": "GCNT3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000032293", "map_id": "ENSXETG00000032293", "name": "GCNT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10320365", "map_id": "none", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_735682", "map_id": "CHEBI:18307", "name": "UDP-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10320292", "map_id": "none", "name": "Tn antigens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10320363", "map_id": "none", "name": "Core 8 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10320383", "map_id": "none", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10320381", "map_id": "none", "name": "Core 6 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10320479", "map_id": "none", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_735700", "map_id": "CHEBI:16650", "name": "UDP-GalNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10320477", "map_id": "none", "name": "Core 7 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10331400", "map_id": "none", "name": "A4GNT transfers GlcNAc to core 2 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10331393", "map_id": "none", "name": "Core 2a mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10331397", "map_id": "A0A6I8RCG9", "name": "LOC100493232", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000037302", "map_id": "ENSXETG00000037302", "name": "LOC100493232", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10320347", "map_id": "none", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10320345", "map_id": "none", "name": "Core 5 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10320327", "map_id": "none", "name": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10320276", "map_id": "none", "name": "Mucins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10320324", "map_id": "none", "name": "GALNTs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q6DJR8", "map_id": "Q6DJR8", "name": "galnt11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040522", "map_id": "ENSXETG00000040522", "name": "galnt11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SNY2", "map_id": "A0A6I8SNY2", "name": "galnt11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6VQB1", "map_id": "F6VQB1", "name": "galnt3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000045011", "map_id": "ENSXETT00000045011", "name": "galnt3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6R8Z5", "map_id": "F6R8Z5", "name": "galnt13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000046964", "map_id": "ENSXETT00000046964", "name": "galnt13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10332295", "map_id": "none", "name": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10332290", "map_id": "none", "name": "Core 2S mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10332292", "map_id": "A0A6I8Q6E3", "name": "chst5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000040380", "map_id": "ENSXETG00000040380", "name": "chst5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10320422", "map_id": "none", "name": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10320399", "map_id": "none", "name": "Core 3 mucins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10320419", "map_id": "none", "name": "B3GNTs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "A0A6I8SXK5", "map_id": "A0A6I8SXK5", "name": "B3GNT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040687", "map_id": "ENSXETG00000040687", "name": "B3GNT6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6P3P5", "map_id": "Q6P3P5", "name": "b3gnt5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000055015", "map_id": "ENSXETT00000055015", "name": "b3gnt5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10320497", "map_id": "none", "name": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10320495", "map_id": "none", "name": "Core 4 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10316180", "map_id": "none", "name": "Phosphorylated FOXO1A is excluded from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10315552", "map_id": "Q66JJ0", "name": "phospho-foxo1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000101788", "map_id": "ENSXETT00000101788", "name": "phospho-foxo1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10316178", "map_id": "Q66JJ0", "name": "phospho-foxo1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10338106", "map_id": "none", "name": "ROCK1,2 bind ROCKi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9686558", "map_id": "none", "name": "ROCKi", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10317786", "map_id": "A0A6I8Q6H0", "name": "rock2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000023782", "map_id": "ENSXETG00000023782", "name": "rock2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317790", "map_id": "none", "name": "ROCK1,ROCK2:ROCKi", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8Q6H0", "map_id": "A0A6I8Q6H0", "name": "rock2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317792", "map_id": "none", "name": "ROCK activation by RHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10317689", "map_id": "none", "name": "RHOA/B/C:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q6NVL3", "map_id": "Q6NVL3", "name": "rhob", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000056231", "map_id": "ENSXETT00000056231", "name": "rhob", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317788", "map_id": "none", "name": "Activated ROCK:RhoA/B/C:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10336907", "map_id": "none", "name": "ADPRHL2 hydrolyses poly(ADP-ribose)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8952909", "map_id": "none", "name": "poly(ADP-ribose)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_8952905", "map_id": "CHEBI:57967", "name": "ADP-ribose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10336904", "map_id": "Q28FQ6", "name": "adprs", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "ENSXETG00000004374", "map_id": "ENSXETG00000004374", "name": "adprs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312814", "map_id": "none", "name": "Translocation of activated BAD protein to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312810", "map_id": "A0A6I8PXS6", "name": "bad", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000031875", "map_id": "ENSXETG00000031875", "name": "bad", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312812", "map_id": "A0A6I8PXS6", "name": "bad", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10312808", "map_id": "none", "name": "Sequestration of BAD protein by 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312790", "map_id": "A0A6I8PXS6", "name": "phospho-bad", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312806", "map_id": "none", "name": "14-3-3 proteins:p-S99-BAD complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8PXS6", "map_id": "A0A6I8PXS6", "name": "bad", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312632", "map_id": "none", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10312624", "map_id": "Q6GLD8", "name": "cdk9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000024742", "map_id": "ENSXETG00000024742", "name": "cdk9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312630", "map_id": "none", "name": "P-TEFb complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q6GLD8", "map_id": "Q6GLD8", "name": "cdk9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328189", "map_id": "none", "name": "WLS:WNT complex is internalized for maturation into exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10327498", "map_id": "none", "name": "WLS:WNT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PTQ1", "map_id": "A0A6I8PTQ1", "name": "wls", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000012387", "map_id": "ENSXETG00000012387", "name": "wls", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QGQ0", "map_id": "A0A6I8QGQ0", "name": "wnt5b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039930", "map_id": "ENSXETG00000039930", "name": "wnt5b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328169", "map_id": "none", "name": "WLS:WNT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828050", "compartment_display": "multivesicular body, internal vesicle", "complex": "true" }, { "id": "reaction_10327518", "map_id": "none", "name": "WLS is endocytosed to the early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10327484", "map_id": "A0A6I8PTQ1", "name": "wls", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10327516", "map_id": "A0A6I8PTQ1", "name": "wls", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "reaction_10327512", "map_id": "none", "name": "secretion of WNT ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10327510", "map_id": "none", "name": "WNTs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8PXW7", "map_id": "A0A6I8PXW7", "name": "wnt10a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031623", "map_id": "ENSXETG00000031623", "name": "wnt10a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PX82", "map_id": "A0A6I8PX82", "name": "wnt10b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000011173", "map_id": "ENSXETG00000011173", "name": "wnt10b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B2GUT4", "map_id": "B2GUT4", "name": "wnt11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000042046", "map_id": "ENSXETT00000042046", "name": "wnt11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R7P2", "map_id": "A0A6I8R7P2", "name": "wnt2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031217", "map_id": "ENSXETG00000031217", "name": "wnt2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328187", "map_id": "none", "name": "WNTs are secreted in exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_383505", "compartment_display": "extracellular exosome" }, { "id": "species_10328185", "map_id": "none", "name": "WLS:WNT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_383505", "compartment_display": "extracellular exosome", "complex": "true" }, { "id": "reaction_10327482", "map_id": "none", "name": "WLS binds WNT ligands in the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10327472", "map_id": "none", "name": "palmitoleyl-N-glycosylated WNTs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10327478", "map_id": "A0A6I8PTQ1", "name": "wls", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10327480", "map_id": "none", "name": "WLS:WNT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10327514", "map_id": "none", "name": "WNT ligands traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10327474", "map_id": "none", "name": "WNT ligands traffic to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10327460", "map_id": "none", "name": "palmitoleyl-N-glycosylated WNTs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10312702", "map_id": "none", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10312698", "map_id": "none", "name": "Homologues of CYCS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "Q6PBF4", "map_id": "Q6PBF4", "name": "cyct", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000049267", "map_id": "ENSXETT00000049267", "name": "cyct", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q640U4", "map_id": "Q640U4", "name": "cycs", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000018532", "map_id": "ENSXETT00000018532", "name": "cycs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312660", "map_id": "none", "name": "Homologues of CYCS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10312700", "map_id": "none", "name": "Activated BAX,BAK oligomers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "A0A6I8QFQ5", "map_id": "A0A6I8QFQ5", "name": "BAK1 activated", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038338", "map_id": "ENSXETG00000038338", "name": "BAK1 activated", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6TEC3", "map_id": "F6TEC3", "name": "BAX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000031936", "map_id": "ENSXETT00000031936", "name": "BAX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337835", "map_id": "none", "name": "SMAC (DIABLO) forms dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312709", "map_id": "Q0IJ31", "name": "diablo", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000008194", "map_id": "ENSXETT00000008194", "name": "diablo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337828", "map_id": "none", "name": "DIABLO dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q0IJ31", "map_id": "Q0IJ31", "name": "diablo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312711", "map_id": "none", "name": "Release of SMAC (DIABLO) from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10312707", "map_id": "Q0IJ31", "name": "diablo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "reaction_10334049", "map_id": "none", "name": "APAF1 binds AVEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312666", "map_id": "none", "name": "APAF1:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8RCL3", "map_id": "A0A6I8RCL3", "name": "apaf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000006695", "map_id": "ENSXETG00000006695", "name": "apaf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10334045", "map_id": "A0A6I8PLL4", "name": "aven", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000017866", "map_id": "ENSXETG00000017866", "name": "aven", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10334047", "map_id": "none", "name": "APAF1:AVEN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8PLL4", "map_id": "A0A6I8PLL4", "name": "aven", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312672", "map_id": "none", "name": "CYCS binds to APAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312670", "map_id": "none", "name": "APAF1:ATP:CYCS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10337832", "map_id": "none", "name": "XIAP binds CASP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312650", "map_id": "none", "name": "Caspase-3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8PZK4", "map_id": "A0A6I8PZK4", "name": "casp3.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000030678", "map_id": "ENSXETG00000030678", "name": "casp3.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10329609", "map_id": "Q5BKL8", "name": "xiap", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000035327", "map_id": "ENSXETT00000035327", "name": "xiap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337826", "map_id": "none", "name": "XIAP:Caspase-3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q5BKL8", "map_id": "Q5BKL8", "name": "xiap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337830", "map_id": "none", "name": "DIABLO:XIAP:Caspase-3", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10337839", "map_id": "none", "name": "SMAC (DIABLO) binds XIAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337837", "map_id": "none", "name": "DIABLO dimer:XIAP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10328555", "map_id": "none", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_4419981", "map_id": "CHEBI:67132", "name": "pPNOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449221", "map_id": "CHEBI:16091", "name": "DCHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10328552", "map_id": "Q0P4J9", "name": "srd5a3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000021063", "map_id": "ENSXETG00000021063", "name": "srd5a3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336283", "map_id": "none", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8869353", "map_id": "CHEBI:14649", "name": "NMN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1132084", "map_id": "CHEBI:33019", "name": "PPi(3-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10314359", "map_id": "none", "name": "NMNAT2:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "A4IH61", "map_id": "A4IH61", "name": "nmnat2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000027403", "map_id": "ENSXETT00000027403", "name": "nmnat2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314362", "map_id": "none", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197220", "map_id": "CHEBI:15763", "name": "NAMN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_197256", "map_id": "CHEBI:18304", "name": "NAAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10335877", "map_id": "none", "name": "NMRK1 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8869377", "map_id": "CHEBI:15927", "name": "NR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10335871", "map_id": "A0A6I8QYR6", "name": "nmrk1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000031505", "map_id": "ENSXETG00000031505", "name": "nmrk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329621", "map_id": "none", "name": "NNMT transfers CH3 from SAM to NAM to form MNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197277", "map_id": "CHEBI:17154", "name": "NAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_549282", "map_id": "CHEBI:16797", "name": "MNA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10336214", "map_id": "none", "name": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8938276", "map_id": "CHEBI:133202", "name": "(ADP-D-ribosyl)(n)-acceptor", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8938282", "map_id": "CHEBI:133203", "name": "(ADP-D-ribosyl)(n+1)-acceptor", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10336211", "map_id": "none", "name": "PARPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A1B8XUU3", "map_id": "A0A1B8XUU3", "name": "parp10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000078735", "map_id": "ENSXETT00000078735", "name": "parp10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6YMQ2", "map_id": "F6YMQ2", "name": "parp8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000038413", "map_id": "ENSXETT00000038413", "name": "parp8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334496", "map_id": "none", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6807473", "map_id": "CHEBI:64085", "name": "R-NADPHX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6807477", "map_id": "CHEBI:64084", "name": "S-NADPHX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10334493", "map_id": "none", "name": "APOA1BP dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A0A5S6NBZ0", "map_id": "A0A5S6NBZ0", "name": "naxe", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000020391", "map_id": "ENSXETG00000020391", "name": "naxe", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335874", "map_id": "none", "name": "NMRK1 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8869365", "map_id": "CHEBI:58527", "name": "NAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10336978", "map_id": "none", "name": "NADK2 dimer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113581", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10336975", "map_id": "none", "name": "NADK2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q08CZ6", "map_id": "Q08CZ6", "name": "nadk2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000010405", "map_id": "ENSXETT00000010405", "name": "nadk2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314353", "map_id": "none", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29386", "map_id": "CHEBI:16238", "name": "FAD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73524", "map_id": "CHEBI:17621", "name": "FMN", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_76577", "map_id": "CHEBI:16027", "name": "AMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10314350", "map_id": "none", "name": "2xENPP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8RYX5", "map_id": "A0A6I8RYX5", "name": "enpp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000030043", "map_id": "ENSXETG00000030043", "name": "enpp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10315543", "map_id": "none", "name": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_76194", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10315540", "map_id": "A0A6I8PT64", "name": "slc25a16", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "ENSXETG00000030903", "map_id": "ENSXETG00000030903", "name": "slc25a16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327160", "map_id": "none", "name": "HLCS biotinylates PC:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_199207", "map_id": "CHEBI:15956", "name": "Btn", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10327148", "map_id": "none", "name": "4x(PC:Mn2+)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8QW74", "map_id": "A0A6I8QW74", "name": "pc.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000008415", "map_id": "ENSXETG00000008415", "name": "pc.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:29035", "map_id": "CHEBI:29035", "name": "CHEBI:29035", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10327153", "map_id": "none", "name": "4x(Btn-PC:Mn2+)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10327157", "map_id": "A0A6I8QGT9", "name": "hlcs", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000013028", "map_id": "ENSXETG00000013028", "name": "hlcs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327703", "map_id": "none", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10327240", "map_id": "none", "name": "4x(Btn-PC:Mn2+)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10331341", "map_id": "none", "name": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_5693984", "map_id": "CHEBI:12071", "name": "5,10-methylene-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_200671", "map_id": "CHEBI:15635", "name": "THF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_379732", "map_id": "CHEBI:33384", "name": "L-Ser", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10331338", "map_id": "none", "name": "PXLP-K280-SHMT2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "A0A6I8RGC7", "map_id": "A0A6I8RGC7", "name": "shmt2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000017162", "map_id": "ENSXETG00000017162", "name": "shmt2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10315636", "map_id": "none", "name": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197969", "map_id": "CHEBI:28624", "name": "THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29424", "map_id": "CHEBI:57305", "name": "Gly", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_200739", "map_id": "CHEBI:60473", "name": "5,10-methylene-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311706", "map_id": "none", "name": "SHMT1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8QRM0", "map_id": "A0A6I8QRM0", "name": "shmt1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000005754", "map_id": "ENSXETG00000005754", "name": "shmt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334535", "map_id": "none", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111353", "map_id": "CHEBI:28010", "name": "10-formyl-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10334532", "map_id": "none", "name": "ALDH1L1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q63ZT8", "map_id": "Q63ZT8", "name": "phospho-aldh1l1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000084678", "map_id": "ENSXETT00000084678", "name": "phospho-aldh1l1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10315634", "map_id": "none", "name": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10320707", "map_id": "none", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947539", "map_id": "CHEBI:25372", "name": "MoCo", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_947575", "map_id": "CHEBI:60102", "name": "sulfurated MoCo", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10320704", "map_id": "A0A6I8R0P4", "name": "MOCOS", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000038002", "map_id": "ENSXETG00000038002", "name": "MOCOS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327276", "map_id": "none", "name": "MMACHC:cob(II)alamin binds MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10327268", "map_id": "A0A6I8Q401", "name": "mmadhc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000004524", "map_id": "ENSXETG00000004524", "name": "mmadhc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10327246", "map_id": "none", "name": "MMACHC:cob(II)alamin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8Q1G4", "map_id": "A0A6I8Q1G4", "name": "mmachc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000003502", "map_id": "ENSXETG00000003502", "name": "mmachc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_3149564", "map_id": "CHEBI:16304", "name": "cob(II)alamin", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10327270", "map_id": "none", "name": "MMACHC:MMADHC:cob(II)alamin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8Q401", "map_id": "A0A6I8Q401", "name": "mmadhc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327279", "map_id": "none", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10327244", "map_id": "A0A6I8Q1G4", "name": "mmachc", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_3149505", "map_id": "CHEBI:17439", "name": "CNCbl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1130611", "map_id": "CHEBI:18407", "name": "HCN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10327274", "map_id": "none", "name": "cob(II)alamin dissociates from MMACHC:MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3149479", "map_id": "CHEBI:16304", "name": "cob(II)alamin", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10327272", "map_id": "none", "name": "MMACHC:MMADHC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10327290", "map_id": "none", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_3159260", "map_id": "CHEBI:15982", "name": "cob(I)alamin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_3159274", "map_id": "CHEBI:15266", "name": "PPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_3159297", "map_id": "CHEBI:18408", "name": "AdoCbl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10327287", "map_id": "none", "name": "3xMMAB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A0A6I8T0P0", "map_id": "A0A6I8T0P0", "name": "mmab", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040875", "map_id": "ENSXETG00000040875", "name": "mmab", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327249", "map_id": "none", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3000241", "map_id": "CHEBI:28911", "name": "Cbl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10327281", "map_id": "none", "name": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10327186", "map_id": "none", "name": "LMBRD1 transports lysosomal Cbl to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3000239", "map_id": "CHEBI:28911", "name": "Cbl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10327183", "map_id": "Q0VGV9", "name": "lmbrd1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "ENSXETT00000025716", "map_id": "ENSXETT00000025716", "name": "lmbrd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327301", "map_id": "none", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_965131", "map_id": "CHEBI:17310", "name": "PXL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_3204324", "map_id": "CHEBI:17405", "name": "PDXate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29408", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10327298", "map_id": "none", "name": "2xAOX1:cofactors", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8RQ40", "map_id": "A0A6I8RQ40", "name": "LOC100493336", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039500", "map_id": "ENSXETG00000039500", "name": "LOC100493336", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:33722", "map_id": "CHEBI:33722", "name": "CHEBI:33722", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:44074", "map_id": "CHEBI:44074", "name": "CHEBI:44074", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314427", "map_id": "none", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1497805", "map_id": "CHEBI:59513", "name": "Asc.-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10314424", "map_id": "none", "name": "CYB5A:heme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_189444", "map_id": "CHEBI:17627", "name": "heme", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10314422", "map_id": "none", "name": "CYB5A:ferriheme", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_917955", "map_id": "CHEBI:36144", "name": "FeHM", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_198816", "map_id": "CHEBI:38290", "name": "AscH-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10314434", "map_id": "none", "name": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_198836", "map_id": "CHEBI:38290", "name": "AscH-", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10314431", "map_id": "B0JZG0", "name": "slc23a2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000099885", "map_id": "ENSXETT00000099885", "name": "slc23a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326701", "map_id": "none", "name": "atREs binds to nascent CM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10326405", "map_id": "none", "name": "nascent CM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SNZ3", "map_id": "A0A6I8SNZ3", "name": "apoa5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038088", "map_id": "ENSXETG00000038088", "name": "apoa5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q08BT8", "map_id": "Q08BT8", "name": "ddah1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000008146", "map_id": "ENSXETT00000008146", "name": "ddah1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2534423", "map_id": "none", "name": "atREs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_2534407", "map_id": "CHEBI:17616", "name": "atR-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:70762", "map_id": "CHEBI:70762", "name": "CHEBI:70762", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:70760", "map_id": "CHEBI:70760", "name": "CHEBI:70760", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:70761", "map_id": "CHEBI:70761", "name": "CHEBI:70761", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326407", "map_id": "none", "name": "nascent CM:atREs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10326780", "map_id": "none", "name": "RBP4 binds atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_2395761", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10326766", "map_id": "F6UH11", "name": "rbp4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETT00000008077", "map_id": "ENSXETT00000008077", "name": "rbp4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326768", "map_id": "none", "name": "RBP4:atROL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "F6UH11", "map_id": "F6UH11", "name": "rbp4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_30209", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10326411", "map_id": "none", "name": "Cytosolic CMs translocate to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10326409", "map_id": "none", "name": "nascent CM:atREs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10320762", "map_id": "none", "name": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_975591", "map_id": "CHEBI:17616", "name": "RPALM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_975590", "map_id": "CHEBI:17336", "name": "atROL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_426576", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10314239", "map_id": "none", "name": "PNLIP:CLPS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "F6ZWX1", "map_id": "F6ZWX1", "name": "PNLIP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000007508", "map_id": "ENSXETT00000007508", "name": "PNLIP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326778", "map_id": "none", "name": "RBP4:atROL binds TTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10326774", "map_id": "none", "name": "TTR tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A4QNN7", "map_id": "A4QNN7", "name": "ttr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000010246", "map_id": "ENSXETT00000010246", "name": "ttr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326776", "map_id": "none", "name": "TTR:RBP4:atROL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10334456", "map_id": "none", "name": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_6806891", "map_id": "CHEBI:28869", "name": "menadione", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_6806657", "map_id": "CHEBI:57533", "name": "GGPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_6806362", "map_id": "CHEBI:78277", "name": "MK4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_6806656", "map_id": "CHEBI:29888", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10334453", "map_id": "Q28HR4", "name": "ubiad1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000017414", "map_id": "ENSXETG00000017414", "name": "ubiad1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323409", "map_id": "none", "name": "Salvage - Sepiapterin is reduced to BH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1497811", "map_id": "CHEBI:16095", "name": "sepiapterin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1497857", "map_id": "CHEBI:15375", "name": "BH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10323229", "map_id": "none", "name": "p-SPR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8PWL6", "map_id": "A0A6I8PWL6", "name": "phospho-spr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033127", "map_id": "ENSXETG00000033127", "name": "phospho-spr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323232", "map_id": "none", "name": "PTHP is reduced to BH4 by sepiapterin reductase (SPR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1474179", "map_id": "CHEBI:17804", "name": "PTHP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29870", "map_id": "CHEBI:15372", "name": "BH4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10323123", "map_id": "none", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1474124", "map_id": "CHEBI:18372", "name": "DHNTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1475054", "map_id": "CHEBI:15266", "name": "PPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10323120", "map_id": "none", "name": "p-PTPS hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8S775", "map_id": "A0A6I8S775", "name": "phospho-pts", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034891", "map_id": "ENSXETG00000034891", "name": "phospho-pts", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327167", "map_id": "none", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2162257", "map_id": "CHEBI:17407", "name": "FPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2995328", "map_id": "CHEBI:24480", "name": "heme O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10327164", "map_id": "A0A6I8SR62", "name": "COX10(?-443)", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "ENSXETG00000033101", "map_id": "ENSXETG00000033101", "name": "COX10(?-443)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314072", "map_id": "none", "name": "UROD decarboxylates URO3 to COPRO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_189407", "map_id": "CHEBI:15437", "name": "URO3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_189455", "map_id": "CHEBI:15439", "name": "COPRO3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10314069", "map_id": "none", "name": "2xUROD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8QYD9", "map_id": "A0A6I8QYD9", "name": "UROD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000041183", "map_id": "ENSXETG00000041183", "name": "UROD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314085", "map_id": "none", "name": "ALAD binds to Pb2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_190173", "map_id": "CHEBI:27889", "name": "Pb2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10314078", "map_id": "none", "name": "8x(ALAD:Zn2+)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F7BED4", "map_id": "F7BED4", "name": "alad", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000050679", "map_id": "ENSXETT00000050679", "name": "alad", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10314083", "map_id": "none", "name": "8xALAD:Pb2+:Zn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10314087", "map_id": "none", "name": "UROD decarboxylates URO1 to COPRO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_190157", "map_id": "CHEBI:28766", "name": "URO1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_190128", "map_id": "CHEBI:28607", "name": "COPRO1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10314081", "map_id": "none", "name": "ALAD condenses 2 dALAs to form PBG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_189489", "map_id": "CHEBI:356416", "name": "dALA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_189464", "map_id": "CHEBI:58126", "name": "PBG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10338037", "map_id": "none", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10338035", "map_id": "none", "name": "BIL:GSTA1, FABP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_189386", "map_id": "CHEBI:16990", "name": "BIL", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10313560", "map_id": "A0A6I8S817", "name": "LOC100496158", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10338039", "map_id": "none", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10311500", "map_id": "none", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76213", "map_id": "CHEBI:30744", "name": "OA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29406", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311497", "map_id": "none", "name": "PXLP-K259-GOT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F6VWW1", "map_id": "F6VWW1", "name": "got1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000039920", "map_id": "ENSXETT00000039920", "name": "got1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10332346", "map_id": "none", "name": "PXLP-K333-GADL1 decarboxylates acidic AAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787759", "map_id": "none", "name": "GADL1 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_6787748", "map_id": "CHEBI:16345", "name": "CSA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:17285", "map_id": "CHEBI:17285", "name": "CHEBI:17285", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6787762", "map_id": "none", "name": "GADL1 products", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_73590", "map_id": "CHEBI:16958", "name": "b-Ala", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1655445", "map_id": "CHEBI:16668", "name": "HTAU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:15891", "map_id": "CHEBI:15891", "name": "CHEBI:15891", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10332343", "map_id": "none", "name": "PXLP-K333-GADL1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q28D99", "map_id": "Q28D99", "name": "gadl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000014481", "map_id": "ENSXETG00000014481", "name": "gadl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311511", "map_id": "none", "name": "PXLP-K259-GOT1 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10331184", "map_id": "none", "name": "ASPA deacetylates NAA to acetate and L-aspartate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5691492", "map_id": "CHEBI:21547", "name": "NAA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10331181", "map_id": "none", "name": "ASPA:Zn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q28C61", "map_id": "Q28C61", "name": "aspa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000005789", "map_id": "ENSXETG00000005789", "name": "aspa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336962", "map_id": "none", "name": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113559", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113553", "map_id": "CHEBI:29991", "name": "L-Asp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8954466", "map_id": "CHEBI:21547", "name": "NAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10336959", "map_id": "A4II32", "name": "nat8l", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "ENSXETG00000002389", "map_id": "ENSXETG00000002389", "name": "nat8l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311532", "map_id": "none", "name": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113594", "map_id": "CHEBI:16810", "name": "2OG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113585", "map_id": "CHEBI:15729", "name": "L-Orn", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_31339", "map_id": "CHEBI:17232", "name": "L-Glu5S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113552", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10311529", "map_id": "none", "name": "OAT hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A0A6I8STU4", "map_id": "A0A6I8STU4", "name": "PXLP-OAT(26-439)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040155", "map_id": "ENSXETG00000040155", "name": "PXLP-OAT(26-439)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311513", "map_id": "none", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_517495", "map_id": "none", "name": "NAD(P)+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_517496", "map_id": "none", "name": "NAD(P)H", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_113561", "map_id": "CHEBI:28938", "name": "NH4+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10311506", "map_id": "none", "name": "GLUD hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q5XGI4", "map_id": "Q5XGI4", "name": "glud1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000103326", "map_id": "ENSXETT00000103326", "name": "glud1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113573", "map_id": "CHEBI:15996", "name": "GTP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10332232", "map_id": "none", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113590", "map_id": "CHEBI:17388", "name": "1PYR-5COOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10332229", "map_id": "none", "name": "PYCR2 decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "F7ALX3", "map_id": "F7ALX3", "name": "endoul2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000021260", "map_id": "ENSXETT00000021260", "name": "endoul2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311541", "map_id": "none", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10311538", "map_id": "none", "name": "PYCR1 decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10311509", "map_id": "none", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10336771", "map_id": "none", "name": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5693762", "map_id": "CHEBI:76931", "name": "NAAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10336766", "map_id": "A0A6I8T209", "name": "rimklb", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000030755", "map_id": "ENSXETG00000030755", "name": "rimklb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311674", "map_id": "none", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31365", "map_id": "CHEBI:15999", "name": "HPPYRA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_30337", "map_id": "CHEBI:16169", "name": "HGTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311671", "map_id": "none", "name": "HPD:AscH-:Fe2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F7AAG5", "map_id": "F7AAG5", "name": "HPD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000008159", "map_id": "ENSXETT00000008159", "name": "HPD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326051", "map_id": "none", "name": "IL4I1:FAD oxidises L-Phe to kPPV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_2160466", "map_id": "CHEBI:18005", "name": "kPPV", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10326048", "map_id": "none", "name": "IL4I1:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A5S6N697", "map_id": "A0A5S6N697", "name": "IL4I1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031027", "map_id": "ENSXETG00000031027", "name": "IL4I1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10332252", "map_id": "none", "name": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6784229", "map_id": "CHEBI:17742", "name": "HOG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_904849", "map_id": "CHEBI:16891", "name": "glyoxylate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113557", "map_id": "CHEBI:15361", "name": "PYR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10332249", "map_id": "none", "name": "HOGA1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q5M8W9", "map_id": "Q5M8W9", "name": "hoga1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000007453", "map_id": "ENSXETT00000007453", "name": "hoga1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10332243", "map_id": "none", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6784215", "map_id": "CHEBI:18240", "name": "HPRO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6784241", "map_id": "CHEBI:27391", "name": "1-pyrroline-3-hydroxy-5-carboxylate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10332240", "map_id": "none", "name": "PRODH2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "A0A6I8SGS7", "map_id": "A0A6I8SGS7", "name": "prodh2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040955", "map_id": "ENSXETG00000040955", "name": "prodh2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334594", "map_id": "none", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_113535", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_141343", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_113575", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389843", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6810070", "map_id": "CHEBI:30744", "name": "OA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10334591", "map_id": "none", "name": "DDO:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "F6TSP3", "map_id": "F6TSP3", "name": "ddo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000046108", "map_id": "ENSXETT00000046108", "name": "ddo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311490", "map_id": "none", "name": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_29896", "map_id": "CHEBI:17544", "name": "HCO3-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113548", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29676", "map_id": "CHEBI:17672", "name": "CAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10311487", "map_id": "A0A6I8Q7A1", "name": "cps1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "ENSXETG00000006919", "map_id": "ENSXETG00000006919", "name": "cps1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_30471", "map_id": "CHEBI:17533", "name": "NAcGlu", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10311481", "map_id": "none", "name": "PXLP-K314-GPT transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10311478", "map_id": "none", "name": "PXLP-K314-GPT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q28DB5", "map_id": "Q28DB5", "name": "gpt2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000007140", "map_id": "ENSXETG00000007140", "name": "gpt2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323908", "map_id": "none", "name": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_352015", "map_id": "CHEBI:17750", "name": "BET", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1614585", "map_id": "CHEBI:17724", "name": "DMGLY", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10323905", "map_id": "none", "name": "BHMT:Zn2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q5M8Z0", "map_id": "Q5M8Z0", "name": "bhmt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000001133", "map_id": "ENSXETT00000001133", "name": "bhmt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10331943", "map_id": "none", "name": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_4789070", "map_id": "CHEBI:17728", "name": "SMM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10331940", "map_id": "none", "name": "BHMT2:Zn2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10322223", "map_id": "none", "name": "Methylthio-ribose-P = Methylthio-ribulose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237165", "map_id": "CHEBI:58533", "name": "MTRIBP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1237107", "map_id": "CHEBI:58548", "name": "MTRIBUP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10322220", "map_id": "Q0VFN1", "name": "mri1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000047323", "map_id": "ENSXETT00000047323", "name": "mri1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10322232", "map_id": "none", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237155", "map_id": "CHEBI:58795", "name": "Acireductone", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29460", "map_id": "CHEBI:30751", "name": "HCOOH", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1237122", "map_id": "CHEBI:16723", "name": "4MTOBUTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10322229", "map_id": "none", "name": "ARD:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6DIY2", "map_id": "Q6DIY2", "name": "adi1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000000659", "map_id": "ENSXETT00000000659", "name": "adi1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10322241", "map_id": "none", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237176", "map_id": "CHEBI:58828", "name": "2,3-DMPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10322238", "map_id": "none", "name": "E1:Mg++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q28C69", "map_id": "Q28C69", "name": "enoph1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000012582", "map_id": "ENSXETG00000012582", "name": "enoph1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334661", "map_id": "none", "name": "PXLP-K333-GADL1 decarboxylates CSA to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10311608", "map_id": "none", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_34979", "map_id": "CHEBI:27384", "name": "4I-5PROA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_30158", "map_id": "CHEBI:18327", "name": "NF-Glu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311605", "map_id": "Q68EP2", "name": "amdhd1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000046755", "map_id": "ENSXETT00000046755", "name": "amdhd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10332309", "map_id": "none", "name": "CARNS1 transforms ATP, L-His, b-Ala to CARN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6786250", "map_id": "CHEBI:15727", "name": "CARN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10332306", "map_id": "A0A6I8QEC1", "name": "carns1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000034643", "map_id": "ENSXETG00000034643", "name": "carns1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311601", "map_id": "none", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30721", "map_id": "CHEBI:30817", "name": "UCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311598", "map_id": "none", "name": "UROC1:NAD+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8R5U8", "map_id": "A0A6I8R5U8", "name": "uroc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000011543", "map_id": "ENSXETG00000011543", "name": "uroc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336008", "map_id": "none", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane" }, { "id": "species_5662670", "map_id": "CHEBI:2003", "name": "DHICA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5668566", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_8878586", "map_id": "CHEBI:81394", "name": "IQCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5668574", "map_id": "CHEBI:15377", "name": "H2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_10336005", "map_id": "A0A6I8S8C5", "name": "tyrp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "false" }, { "id": "ENSXETG00000012905", "map_id": "ENSXETG00000012905", "name": "tyrp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311617", "map_id": "none", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113556", "map_id": "CHEBI:17917", "name": "2AMAS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_508531", "map_id": "CHEBI:17082", "name": "2AMA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10311614", "map_id": "none", "name": "ALDH7A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "F7BQF6", "map_id": "F7BQF6", "name": "aldh7a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000011316", "map_id": "ENSXETT00000011316", "name": "aldh7a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336981", "map_id": "none", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113597", "map_id": "CHEBI:16238", "name": "FAD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_164934", "map_id": "CHEBI:17877", "name": "FADH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10332236", "map_id": "A0A6I8SGS7", "name": "prodh2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10316697", "map_id": "none", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_353560", "map_id": "CHEBI:15746", "name": "SPN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76183", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_353575", "map_id": "CHEBI:17312", "name": "NASPN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10316694", "map_id": "A0A6I8SZY0", "name": "satl1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000039007", "map_id": "ENSXETG00000039007", "name": "satl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316699", "map_id": "none", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_204635", "map_id": "CHEBI:16610", "name": "SPM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_353555", "map_id": "CHEBI:17927", "name": "NASPM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10316690", "map_id": "none", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_351164", "map_id": "CHEBI:17431", "name": "AGM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10316687", "map_id": "A0A6I8QKY2", "name": "LOC100498594", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000040919", "map_id": "ENSXETG00000040919", "name": "LOC100498594", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311558", "map_id": "none", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29498", "map_id": "CHEBI:15729", "name": "L-Orn", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_29610", "map_id": "CHEBI:17148", "name": "Putrescine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311555", "map_id": "none", "name": "Homologues of PXLP-K69-ODC1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8QKY2", "map_id": "A0A6I8QKY2", "name": "LOC100498594", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6VJF3", "map_id": "F6VJF3", "name": "odc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000007603", "map_id": "ENSXETT00000007603", "name": "odc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311567", "map_id": "none", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70772", "map_id": "CHEBI:15488", "name": "bMC-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_70784", "map_id": "CHEBI:15467", "name": "bHMG-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10311564", "map_id": "none", "name": "AUH hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "F7DXL6", "map_id": "F7DXL6", "name": "AUH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000001790", "map_id": "ENSXETT00000001790", "name": "AUH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311576", "map_id": "none", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70718", "map_id": "CHEBI:15477", "name": "2MBUT-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_70799", "map_id": "CHEBI:15478", "name": "tiglyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_31649", "map_id": "CHEBI:17877", "name": "FADH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10311573", "map_id": "none", "name": "ACADSB tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "F6VHN6", "map_id": "F6VHN6", "name": "ivd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000035066", "map_id": "ENSXETT00000035066", "name": "ivd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311592", "map_id": "none", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_71847", "map_id": "CHEBI:28259", "name": "bHIB-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_573404", "map_id": "CHEBI:11805", "name": "bHIBA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10311589", "map_id": "Q28FR6", "name": "hibch", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "ENSXETT00000033364", "map_id": "ENSXETT00000033364", "name": "hibch", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311585", "map_id": "none", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70836", "map_id": "CHEBI:15476", "name": "2MACA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_70843", "map_id": "CHEBI:15539", "name": "PROP-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10311582", "map_id": "none", "name": "ACAT1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q5BKN8", "map_id": "Q5BKN8", "name": "acat1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000031684", "map_id": "ENSXETT00000031684", "name": "acat1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311725", "map_id": "none", "name": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30401", "map_id": "CHEBI:16344", "name": "GAA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29916", "map_id": "CHEBI:16919", "name": "CRET", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311722", "map_id": "Q6PBF6", "name": "gamt", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000003703", "map_id": "ENSXETG00000003703", "name": "gamt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311718", "map_id": "none", "name": "arginine + glycine => ornithine + guanidoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_113530", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_113545", "map_id": "CHEBI:57305", "name": "Gly", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_113543", "map_id": "CHEBI:16344", "name": "GAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_113586", "map_id": "CHEBI:15729", "name": "L-Orn", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10311715", "map_id": "none", "name": "GATM dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "Q6P832", "map_id": "Q6P832", "name": "gatm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000035125", "map_id": "ENSXETT00000035125", "name": "gatm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10332468", "map_id": "none", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6798194", "map_id": "CHEBI:15710", "name": "BETALD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6798202", "map_id": "CHEBI:17750", "name": "BET", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10311612", "map_id": "F7BQF6", "name": "aldh7a1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10311690", "map_id": "none", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29970", "map_id": "CHEBI:16946", "name": "L-KYN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_34351", "map_id": "CHEBI:17380", "name": "3HKYN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311687", "map_id": "Q6DIZ8", "name": "kmo", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000035436", "map_id": "ENSXETT00000035436", "name": "kmo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311683", "map_id": "none", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_33179", "map_id": "CHEBI:18377", "name": "NFK", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311680", "map_id": "none", "name": "TDO2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q5EBG2", "map_id": "Q5EBG2", "name": "tdo2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000048482", "map_id": "ENSXETT00000048482", "name": "tdo2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311699", "map_id": "none", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30487", "map_id": "CHEBI:15793", "name": "3HAA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_36027", "map_id": "CHEBI:29044", "name": "ACS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311696", "map_id": "none", "name": "HAAO", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6DIZ0", "map_id": "Q6DIZ0", "name": "haao", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000015771", "map_id": "ENSXETG00000015771", "name": "haao", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326790", "map_id": "none", "name": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5359016", "map_id": "none", "name": "reduced acceptor", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5357697", "map_id": "CHEBI:16633", "name": "Sec", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5357660", "map_id": "CHEBI:16503", "name": "H2Se", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5359011", "map_id": "none", "name": "acceptor", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10326787", "map_id": "none", "name": "PXLP-K259-SCLY dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q5U4Q9", "map_id": "Q5U4Q9", "name": "scly", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000026454", "map_id": "ENSXETT00000026454", "name": "scly", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311709", "map_id": "none", "name": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31503", "map_id": "CHEBI:15786", "name": "HTMLYS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31311", "map_id": "CHEBI:18020", "name": "TEABL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10311917", "map_id": "none", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_83928", "map_id": "CHEBI:17748", "name": "Thy-dRib", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_109366", "map_id": "CHEBI:17013", "name": "TMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10311914", "map_id": "none", "name": "TK1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SMB6", "map_id": "A0A6I8SMB6", "name": "tk1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000001323", "map_id": "ENSXETG00000001323", "name": "tk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312345", "map_id": "none", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500759", "map_id": "none", "name": "Cyt-Rib, Ura-Rib", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16704", "map_id": "CHEBI:16704", "name": "CHEBI:16704", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17562", "map_id": "CHEBI:17562", "name": "CHEBI:17562", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500761", "map_id": "none", "name": "CMP, UMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_727810", "map_id": "CHEBI:17361", "name": "CMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_109402", "map_id": "CHEBI:16695", "name": "UMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312342", "map_id": "none", "name": "UCK2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "B1H116", "map_id": "B1H116", "name": "uck2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000037794", "map_id": "ENSXETT00000037794", "name": "uck2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311908", "map_id": "none", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500829", "map_id": "none", "name": "Cyt-Rib, dC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:15698", "map_id": "CHEBI:15698", "name": "CHEBI:15698", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500430", "map_id": "none", "name": "(d)Ura", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16450", "map_id": "CHEBI:16450", "name": "CHEBI:16450", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10311905", "map_id": "none", "name": "CDA tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SN57", "map_id": "A0A6I8SN57", "name": "CDA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037611", "map_id": "ENSXETG00000037611", "name": "CDA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311993", "map_id": "none", "name": "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500173", "map_id": "none", "name": "Ade-Rib, dA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_8857850", "map_id": "CHEBI:16335", "name": "adenosine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "CHEBI:17256", "map_id": "CHEBI:17256", "name": "CHEBI:17256", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500172", "map_id": "none", "name": "Ino, dI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28997", "map_id": "CHEBI:28997", "name": "CHEBI:28997", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_83927", "map_id": "CHEBI:17596", "name": "Ino", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10311990", "map_id": "Q63ZU0", "name": "ada", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000003459", "map_id": "ENSXETG00000003459", "name": "ada", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312600", "map_id": "none", "name": "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_113599", "map_id": "CHEBI:17368", "name": "Hyp", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_500244", "map_id": "none", "name": "R1P, dRibP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28542", "map_id": "CHEBI:28542", "name": "CHEBI:28542", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:35425", "map_id": "CHEBI:35425", "name": "CHEBI:35425", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10311999", "map_id": "none", "name": "NP trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SRS9", "map_id": "A0A6I8SRS9", "name": "pnp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000016932", "map_id": "ENSXETG00000016932", "name": "pnp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312602", "map_id": "none", "name": "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_83956", "map_id": "CHEBI:16235", "name": "Gua", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_500245", "map_id": "none", "name": "G, dG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:17172", "map_id": "CHEBI:17172", "name": "CHEBI:17172", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16750", "map_id": "CHEBI:16750", "name": "CHEBI:16750", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312245", "map_id": "none", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29602", "map_id": "CHEBI:17202", "name": "IMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312242", "map_id": "none", "name": "AMPD2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SRY8", "map_id": "A0A6I8SRY8", "name": "ampd2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000002009", "map_id": "ENSXETG00000002009", "name": "ampd2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311986", "map_id": "none", "name": "guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73566", "map_id": "CHEBI:17111", "name": "PRPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_500259", "map_id": "none", "name": "Gua, Hyp", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500260", "map_id": "none", "name": "GMP, IMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5696194", "map_id": "CHEBI:17345", "name": "GMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10311983", "map_id": "none", "name": "HGPRT tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SQB1", "map_id": "A0A6I8SQB1", "name": "hprt1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000019768", "map_id": "ENSXETG00000019768", "name": "hprt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312364", "map_id": "none", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6788782", "map_id": "none", "name": "(d)NDPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28846", "map_id": "CHEBI:28846", "name": "CHEBI:28846", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16174", "map_id": "CHEBI:16174", "name": "CHEBI:16174", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17239", "map_id": "CHEBI:17239", "name": "CHEBI:17239", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6788778", "map_id": "none", "name": "(d)NMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:15918", "map_id": "CHEBI:15918", "name": "CHEBI:15918", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17713", "map_id": "CHEBI:17713", "name": "CHEBI:17713", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312361", "map_id": "none", "name": "AK5,7,8,9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6P618", "map_id": "Q6P618", "name": "ak8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000006260", "map_id": "ENSXETG00000006260", "name": "ak8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q090", "map_id": "A0A6I8Q090", "name": "ak5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033226", "map_id": "ENSXETG00000033226", "name": "ak5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312076", "map_id": "none", "name": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500006", "map_id": "none", "name": "(d)CDP, UDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_417888", "map_id": "CHEBI:17659", "name": "UDP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_500009", "map_id": "none", "name": "(d)CMP, UMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10311896", "map_id": "A0A6I8QT96", "name": "cmpk1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000036011", "map_id": "ENSXETG00000036011", "name": "cmpk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312366", "map_id": "none", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10312373", "map_id": "none", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312370", "map_id": "Q28F55", "name": "ak2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "ENSXETT00000057918", "map_id": "ENSXETT00000057918", "name": "ak2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312550", "map_id": "none", "name": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312547", "map_id": "A0A6I8SU32", "name": "glrx", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000026267", "map_id": "ENSXETG00000026267", "name": "glrx", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312544", "map_id": "A0A6I8SU32", "name": "glrx", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111745", "map_id": "CHEBI:17858", "name": "GSSG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10311926", "map_id": "none", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_500739", "map_id": "CHEBI:17625", "name": "dUTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113541", "map_id": "CHEBI:29888", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_500742", "map_id": "CHEBI:17622", "name": "dUMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10311923", "map_id": "none", "name": "DUT trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8RWX6", "map_id": "A0A6I8RWX6", "name": "dut", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036738", "map_id": "ENSXETG00000036738", "name": "dut", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326748", "map_id": "none", "name": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2395883", "map_id": "CHEBI:63728", "name": "8-oxo-dGDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2395817", "map_id": "CHEBI:63223", "name": "8-oxo-dGMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10326740", "map_id": "A0A6I8Q918", "name": "nudt18", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000037630", "map_id": "ENSXETG00000037630", "name": "nudt18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326751", "map_id": "none", "name": "NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2395963", "map_id": "CHEBI:70963", "name": "8-hydroxy-dADP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2395964", "map_id": "CHEBI:70964", "name": "8-hydroxy-dAMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10326734", "map_id": "none", "name": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2395852", "map_id": "CHEBI:63220", "name": "8-oxo-dGTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10326731", "map_id": "A0A6I8SF49", "name": "nudt15", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000039868", "map_id": "ENSXETG00000039868", "name": "nudt15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326746", "map_id": "none", "name": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10326724", "map_id": "none", "name": "NUDT1 hydrolyses 2-OH-dATP to 2-OH-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2395822", "map_id": "CHEBI:63208", "name": "2-hydroxy-dATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2395855", "map_id": "CHEBI:63211", "name": "2-hydroxy-dAMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10326721", "map_id": "none", "name": "NUDT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6GL35", "map_id": "Q6GL35", "name": "nudt1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000085967", "map_id": "ENSXETT00000085967", "name": "nudt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326727", "map_id": "none", "name": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10326743", "map_id": "none", "name": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2395880", "map_id": "CHEBI:65134", "name": "8-oxo-GDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2395877", "map_id": "CHEBI:65135", "name": "8-oxo-GMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10331430", "map_id": "none", "name": "ADPRM hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1131972", "map_id": "CHEBI:16960", "name": "ADP-D-ribose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73578", "map_id": "CHEBI:78679", "name": "R5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10331427", "map_id": "none", "name": "ADPRM:Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q66JJ3", "map_id": "Q66JJ3", "name": "adprm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000024142", "map_id": "ENSXETT00000024142", "name": "adprm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326736", "map_id": "none", "name": "NUDT1 hydrolyses 2-OH-ATP to 2-OH-AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2395868", "map_id": "CHEBI:65119", "name": "2-hydroxy-ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2395878", "map_id": "CHEBI:65129", "name": "2-hydroxy-AMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10312296", "map_id": "none", "name": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500125", "map_id": "none", "name": "(d)AMP, (d)GMP, (d)IMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_109330", "map_id": "CHEBI:28806", "name": "dIMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:16192", "map_id": "CHEBI:16192", "name": "CHEBI:16192", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500124", "map_id": "none", "name": "(d)A, (d)G, (d)I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10312291", "map_id": "none", "name": "NT5C1A tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8QEC6", "map_id": "A0A6I8QEC6", "name": "nt5c1b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037368", "map_id": "ENSXETG00000037368", "name": "nt5c1b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326856", "map_id": "none", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509835", "map_id": "CHEBI:28807", "name": "dITP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10326847", "map_id": "none", "name": "ITPA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SWT3", "map_id": "A0A6I8SWT3", "name": "itpa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036089", "map_id": "ENSXETG00000036089", "name": "itpa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29926", "map_id": "CHEBI:18420", "name": "Mg2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10312011", "map_id": "none", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500120", "map_id": "none", "name": "(d)GMP, (d)IMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500118", "map_id": "none", "name": "Gu-Rib, dG, Ino, dI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10312008", "map_id": "none", "name": "NT5C2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q5EBF1", "map_id": "Q5EBF1", "name": "nt5c2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000009475", "map_id": "ENSXETG00000009475", "name": "nt5c2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326853", "map_id": "none", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509848", "map_id": "CHEBI:10049", "name": "XTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111584", "map_id": "CHEBI:15652", "name": "XMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10312305", "map_id": "none", "name": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312302", "map_id": "none", "name": "NT5C dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8QJ17", "map_id": "A0A6I8QJ17", "name": "nt5m", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037325", "map_id": "ENSXETG00000037325", "name": "nt5m", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326850", "map_id": "none", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509836", "map_id": "CHEBI:16039", "name": "ITP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10312314", "map_id": "none", "name": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_500420", "map_id": "none", "name": "TMP, UMP, dU5MP, U2MP, U3MP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:28895", "map_id": "CHEBI:28895", "name": "CHEBI:28895", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28070", "map_id": "CHEBI:28070", "name": "CHEBI:28070", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500421", "map_id": "none", "name": "Thy-dRib, Ura-Rib, dU", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10312311", "map_id": "none", "name": "NT5M dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10312294", "map_id": "none", "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500347", "map_id": "none", "name": "(d)CMP, TMP, (d)UMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500346", "map_id": "none", "name": "(d)C, T, (d)U", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10312307", "map_id": "none", "name": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500414", "map_id": "none", "name": "TMP, U2MP, U3MP, UMP, dU3MP, dUMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:46322", "map_id": "CHEBI:46322", "name": "CHEBI:46322", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500415", "map_id": "none", "name": "Thy-Rib, (d)U", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10334973", "map_id": "none", "name": "NTPDase5 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8936165", "map_id": "none", "name": "ADP,GDP,CDP,UDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_8851369", "map_id": "none", "name": "AMP,GMP,CMP,UMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10334970", "map_id": "none", "name": "NPTDase5:Ca2+,Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8Q679", "map_id": "A0A6I8Q679", "name": "entpd5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000030591", "map_id": "ENSXETG00000030591", "name": "entpd5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334998", "map_id": "none", "name": "NTPDase7 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_528865", "compartment_display": "endocytic vesicle lumen" }, { "id": "species_8851517", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_528865", "compartment_display": "endocytic vesicle lumen", "complex": "false" }, { "id": "species_8851509", "map_id": "none", "name": "CTP,GTP,UTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_528865", "compartment_display": "endocytic vesicle lumen", "complex": "true" }, { "id": "CHEBI:15713", "map_id": "CHEBI:15713", "name": "CHEBI:15713", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17677", "map_id": "CHEBI:17677", "name": "CHEBI:17677", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8851513", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_528865", "compartment_display": "endocytic vesicle lumen", "complex": "false" }, { "id": "species_8851518", "map_id": "none", "name": "CDP,GDP,UDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_528865", "compartment_display": "endocytic vesicle lumen", "complex": "true" }, { "id": "species_10334995", "map_id": "none", "name": "NTPDase7:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane", "complex": "true" }, { "id": "Q28CF8", "map_id": "Q28CF8", "name": "entpd7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000003746", "map_id": "ENSXETG00000003746", "name": "entpd7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334848", "map_id": "none", "name": "NTPDase1 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8870907", "map_id": "CHEBI:17326", "name": "NTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8870906", "map_id": "CHEBI:16862", "name": "NDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10334845", "map_id": "none", "name": "NTPDase1:Ca2+,Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8QSY1", "map_id": "A0A6I8QSY1", "name": "ENTPD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037156", "map_id": "ENSXETG00000037156", "name": "ENTPD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334960", "map_id": "none", "name": "NTPDase2 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8936166", "map_id": "none", "name": "ATP,GTP,CTP,ITP,UTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_8851092", "map_id": "none", "name": "ADP,GDP,CDP,IDP,UDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:17808", "map_id": "CHEBI:17808", "name": "CHEBI:17808", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10334957", "map_id": "none", "name": "NTPDase2:Ca2+,Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "K9J7Q8", "map_id": "K9J7Q8", "name": "entpd8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000008576", "map_id": "ENSXETT00000008576", "name": "entpd8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334851", "map_id": "none", "name": "NTPDase1 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_8870962", "map_id": "CHEBI:26558", "name": "NMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10311933", "map_id": "none", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_113578", "map_id": "CHEBI:17345", "name": "GMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311930", "map_id": "A0A6I8QXB3", "name": "gmps", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000033049", "map_id": "ENSXETG00000033049", "name": "gmps", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312540", "map_id": "none", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_35141", "map_id": "CHEBI:15919", "name": "ADS", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312537", "map_id": "none", "name": "ADSS, ADSSL1 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6DIW6", "map_id": "Q6DIW6", "name": "adss1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000024695", "map_id": "ENSXETG00000024695", "name": "adss1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6P875", "map_id": "Q6P875", "name": "adss2-a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000014538", "map_id": "ENSXETG00000014538", "name": "adss2-a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_30014", "map_id": "CHEBI:32966", "name": "F1,6PP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10311946", "map_id": "none", "name": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111292", "map_id": "CHEBI:17284", "name": "PRA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111338", "map_id": "CHEBI:18349", "name": "PRGA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311937", "map_id": "A0A6I8RNQ3", "name": "gart", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000014148", "map_id": "ENSXETG00000014148", "name": "gart", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311940", "map_id": "none", "name": "FGAM + ATP => AIR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111369", "map_id": "CHEBI:18413", "name": "FGAM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111370", "map_id": "CHEBI:28843", "name": "AIR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10311943", "map_id": "none", "name": "GAR + 10-Formyl-THF => FGAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_419151", "map_id": "CHEBI:15637", "name": "10-formyl-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111354", "map_id": "CHEBI:18272", "name": "N-Formyl-GAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111355", "map_id": "CHEBI:15635", "name": "THF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10332370", "map_id": "none", "name": "LHPP:Mg2+ dimer hydrolyses PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10332367", "map_id": "none", "name": "LHPP:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8PWJ2", "map_id": "A0A6I8PWJ2", "name": "lhpp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031230", "map_id": "ENSXETG00000031230", "name": "lhpp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10315931", "map_id": "none", "name": "eNOS binds NOSIP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10315923", "map_id": "none", "name": "palmitoylated, myristoylated eNOS dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8RYH7", "map_id": "A0A6I8RYH7", "name": "nos3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000011979", "map_id": "ENSXETG00000011979", "name": "nos3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10315927", "map_id": "Q6P829", "name": "nosip", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000065273", "map_id": "ENSXETT00000065273", "name": "nosip", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10315929", "map_id": "none", "name": "eNOS:NOSIP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q6P829", "map_id": "Q6P829", "name": "nosip", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10315952", "map_id": "none", "name": "eNOS:NOSIP translocation from caveolae to intracellular compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10315950", "map_id": "none", "name": "eNOS:NOSIP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10315944", "map_id": "none", "name": "N-myristoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_184174", "map_id": "CHEBI:15532", "name": "MYS-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10315942", "map_id": "A0A6I8RYH7", "name": "nos3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10315712", "map_id": "A0A6I8RYH7", "name": "nos3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10315720", "map_id": "none", "name": "depalmitoylated eNOS translocates from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10315714", "map_id": "none", "name": "myristoylated eNOS dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10315718", "map_id": "none", "name": "myristoylated eNOS dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10315940", "map_id": "none", "name": "palmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_200993", "map_id": "CHEBI:15525", "name": "PALM-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10315933", "map_id": "A0A6I8RYH7", "name": "nos3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10315937", "map_id": "Q28F05", "name": "zdhhc21", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETT00000055800", "map_id": "ENSXETT00000055800", "name": "zdhhc21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329588", "map_id": "none", "name": "CYGB dioxygenates NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_202124", "map_id": "CHEBI:16480", "name": "NO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10329583", "map_id": "none", "name": "CYGB dimer:O2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6DEW1", "map_id": "Q6DEW1", "name": "cygb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000093870", "map_id": "ENSXETT00000093870", "name": "cygb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_432031", "map_id": "CHEBI:17632", "name": "NO3-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10329581", "map_id": "none", "name": "CYGB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10329585", "map_id": "none", "name": "CYGB binds O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10315954", "map_id": "none", "name": "eNOS translocation from Golgi to Caveolae", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10313418", "map_id": "none", "name": "Protons are translocated from the intermembrane space to the matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10313240", "map_id": "none", "name": "UCP dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "F7AQ05", "map_id": "F7AQ05", "name": "ucp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000055772", "map_id": "ENSXETT00000055772", "name": "ucp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A9ULC3", "map_id": "A9ULC3", "name": "ucp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000060557", "map_id": "ENSXETT00000060557", "name": "ucp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SUP0", "map_id": "A0A6I8SUP0", "name": "slc25a27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000016256", "map_id": "ENSXETG00000016256", "name": "slc25a27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QNV8", "map_id": "A0A6I8QNV8", "name": "ucp3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034740", "map_id": "ENSXETG00000034740", "name": "ucp3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_170037", "map_id": "none", "name": "Purine nucleotide", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10313247", "map_id": "none", "name": "FA anion flip-flops to the opposite surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10313242", "map_id": "none", "name": "FA anion:UCP dimer \"head-in\" complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_166216", "map_id": "CHEBI:28868", "name": "Fatty Acid anion \"head-out\"", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10313244", "map_id": "none", "name": "FA anion:UCP dimer \"head-out\" complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10313249", "map_id": "none", "name": "FA anion diffuses laterally to UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_166213", "map_id": "CHEBI:28868", "name": "Fatty Acid anion \"head-in\"", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10313251", "map_id": "none", "name": "The FA anion diffuses away laterally from UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "reaction_10338068", "map_id": "none", "name": "PM20D1 hydrolyzes oleoyl-phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9673044", "map_id": "CHEBI:134020", "name": "oleoyl-Phe", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_9673048", "map_id": "CHEBI:30823", "name": "oleate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10338063", "map_id": "Q08BT9", "name": "pm20d1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000005950", "map_id": "ENSXETG00000005950", "name": "pm20d1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10338066", "map_id": "none", "name": "PM20D1 transforms oleoyl-phe from oleate and phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10320175", "map_id": "none", "name": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_880046", "map_id": "CHEBI:57706", "name": "SUCCSA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_879997", "map_id": "CHEBI:32796", "name": "2HG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_880041", "map_id": "CHEBI:16724", "name": "HBUT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10320172", "map_id": "Q6P371", "name": "adhfe1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "ENSXETG00000023251", "map_id": "ENSXETG00000023251", "name": "adhfe1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10332223", "map_id": "none", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5694130", "map_id": "CHEBI:15694", "name": "(R)-S-LGSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29708", "map_id": "CHEBI:422", "name": "LACT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10332220", "map_id": "none", "name": "HAGH-2:2xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "B4F6K2", "map_id": "B4F6K2", "name": "hagh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000007202", "map_id": "ENSXETG00000007202", "name": "hagh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337199", "map_id": "none", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113587", "map_id": "CHEBI:30744", "name": "OAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29376", "map_id": "CHEBI:16526", "name": "CO2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10337196", "map_id": "none", "name": "FAHD1:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A0A6I8PLR1", "map_id": "A0A6I8PLR1", "name": "fahd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033843", "map_id": "ENSXETG00000033843", "name": "fahd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318622", "map_id": "none", "name": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_29938", "map_id": "CHEBI:151", "name": "ISCIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10318619", "map_id": "none", "name": "IDH2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "F6WI63", "map_id": "F6WI63", "name": "idh1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000017597", "map_id": "ENSXETT00000017597", "name": "idh1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311626", "map_id": "none", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_29654", "map_id": "CHEBI:30769", "name": "CIT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10311623", "map_id": "none", "name": "CS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q28DK1", "map_id": "Q28DK1", "name": "cs", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000020990", "map_id": "ENSXETT00000020990", "name": "cs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311649", "map_id": "none", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113536", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113588", "map_id": "CHEBI:18012", "name": "FUMA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10311646", "map_id": "none", "name": "SDH complex (ox.)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q6P355", "map_id": "Q6P355", "name": "sdhd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000057629", "map_id": "ENSXETT00000057629", "name": "sdhd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0BM36", "map_id": "B0BM36", "name": "sdhb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000013435", "map_id": "ENSXETG00000013435", "name": "sdhb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28ED0", "map_id": "Q28ED0", "name": "sdha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000087904", "map_id": "ENSXETT00000087904", "name": "sdha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311869", "map_id": "none", "name": "pyrophosphate + H2O => 2 orthophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10311866", "map_id": "none", "name": "PPA1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8S9S0", "map_id": "A0A6I8S9S0", "name": "ppa1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000014102", "map_id": "ENSXETG00000014102", "name": "ppa1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318570", "map_id": "none", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10318567", "map_id": "none", "name": "PPA2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10330207", "map_id": "none", "name": "SORD oxidizes D-sorbitol to Fru", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5652213", "map_id": "CHEBI:17924", "name": "D-sorbitol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29532", "map_id": "CHEBI:15824", "name": "Fru", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10330204", "map_id": "none", "name": "SORD tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8PMG1", "map_id": "A0A6I8PMG1", "name": "sord", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000023897", "map_id": "ENSXETG00000023897", "name": "sord", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337689", "map_id": "none", "name": "GAA hydrolyzes lysosomal glycogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10337678", "map_id": "none", "name": "glycogen-GYG1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "A0A6I8SJ17", "map_id": "A0A6I8SJ17", "name": "gyg1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000016072", "map_id": "ENSXETG00000016072", "name": "gyg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337682", "map_id": "none", "name": "poly((1,4)-alpha-glucosyl)GYG1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_1605745", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10337684", "map_id": "F6WCE6", "name": "adamts4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "ENSXETT00000002749", "map_id": "ENSXETT00000002749", "name": "adamts4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337919", "map_id": "none", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29548", "map_id": "CHEBI:16077", "name": "G1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_30537", "map_id": "CHEBI:58225", "name": "G6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10337916", "map_id": "none", "name": "PGM1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F6PKQ4", "map_id": "F6PKQ4", "name": "pgm1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000023697", "map_id": "ENSXETT00000023697", "name": "pgm1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311436", "map_id": "none", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10311433", "map_id": "none", "name": "phosphofructokinase, M4 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8RGQ8", "map_id": "A0A6I8RGQ8", "name": "pfkm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000007279", "map_id": "ENSXETG00000007279", "name": "pfkm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_76190", "map_id": "CHEBI:30769", "name": "CIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10333611", "map_id": "none", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_449701", "map_id": "CHEBI:15873", "name": "GlcN6P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10333608", "map_id": "none", "name": "GNPDA2 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A4IHW6", "map_id": "A4IHW6", "name": "gnpda2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000018476", "map_id": "ENSXETT00000018476", "name": "gnpda2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311418", "map_id": "none", "name": "HK1,2,3,GCK phosphorylate Glc to form G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10311413", "map_id": "L7N2L6", "name": "LOC100486155", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000005874", "map_id": "ENSXETT00000005874", "name": "LOC100486155", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311878", "map_id": "none", "name": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29800", "map_id": "CHEBI:57604", "name": "1,3BPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29728", "map_id": "CHEBI:58272", "name": "3PG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311459", "map_id": "none", "name": "PGK complexes", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SHY7", "map_id": "A0A6I8SHY7", "name": "pgk1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000007447", "map_id": "ENSXETG00000007447", "name": "pgk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311427", "map_id": "none", "name": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_75970", "map_id": "CHEBI:57642", "name": "DHAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29578", "map_id": "CHEBI:59776", "name": "GA3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311424", "map_id": "none", "name": "TPI1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "B0BM40", "map_id": "B0BM40", "name": "tpi1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000023924", "map_id": "ENSXETG00000023924", "name": "tpi1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327532", "map_id": "none", "name": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_113782", "map_id": "CHEBI:58225", "name": "G6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113551", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113780", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10327529", "map_id": "A0A6I8PUG8", "name": "g6pc3.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000032824", "map_id": "ENSXETG00000032824", "name": "g6pc3.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311471", "map_id": "none", "name": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10311468", "map_id": "none", "name": "pyruvate carboxylase holoenzyme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10314378", "map_id": "none", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_198498", "map_id": "CHEBI:30797", "name": "MAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10314375", "map_id": "none", "name": "malate dehydrogenase 1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6DIY9", "map_id": "Q6DIY9", "name": "mdh1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000101573", "map_id": "ENSXETT00000101573", "name": "mdh1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311445", "map_id": "none", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10311442", "map_id": "none", "name": "FBP1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6P8F7", "map_id": "Q6P8F7", "name": "fbp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000049063", "map_id": "ENSXETT00000049063", "name": "fbp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327525", "map_id": "none", "name": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10327522", "map_id": "Q5M7K3", "name": "slc37a2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETT00000094617", "map_id": "ENSXETT00000094617", "name": "slc37a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311876", "map_id": "none", "name": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10311873", "map_id": "A8WH23", "name": "g6pc.2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETT00000033981", "map_id": "ENSXETT00000033981", "name": "g6pc.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325949", "map_id": "none", "name": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10325677", "map_id": "none", "name": "HS(5)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "Q0V9W0", "map_id": "Q0V9W0", "name": "gpc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000104077", "map_id": "ENSXETT00000104077", "name": "gpc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R5Q9", "map_id": "A0A6I8R5Q9", "name": "phospho-sdc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035467", "map_id": "ENSXETG00000035467", "name": "phospho-sdc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PYW4", "map_id": "A0A6I8PYW4", "name": "sdc3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000007104", "map_id": "ENSXETG00000007104", "name": "sdc3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SBK0", "map_id": "A0A6I8SBK0", "name": "gpc3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000032333", "map_id": "ENSXETG00000032333", "name": "gpc3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R4L4", "map_id": "A0A6I8R4L4", "name": "gpc6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039039", "map_id": "ENSXETG00000039039", "name": "gpc6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10325691", "map_id": "none", "name": "HS/HPIN-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10325946", "map_id": "F7EF22", "name": "hs6st2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETT00000011900", "map_id": "ENSXETT00000011900", "name": "hs6st2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325593", "map_id": "none", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10325590", "map_id": "none", "name": "Heparan(3)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10325545", "map_id": "none", "name": "Heparan(4)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10325568", "map_id": "Q5U4X8", "name": "ndst1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000015804", "map_id": "ENSXETG00000015804", "name": "ndst1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10319098", "map_id": "none", "name": "SLC35D2 exchanges UDP-sugars for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_744229", "map_id": "none", "name": "UDP-GlcNAc, UDP-Glc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_744227", "map_id": "CHEBI:18066", "name": "UDP-Glc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_162756", "map_id": "CHEBI:16264", "name": "UDP-GlcNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_735698", "map_id": "CHEBI:16695", "name": "uridine 5'-monophosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_744234", "map_id": "none", "name": "UDP-GlcNAc, UDP-Glc", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10319093", "map_id": "A0A6I8T280", "name": "slc35d2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000041312", "map_id": "ENSXETG00000041312", "name": "slc35d2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325767", "map_id": "none", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10325693", "map_id": "none", "name": "HSPGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10325765", "map_id": "none", "name": "HSPGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10325571", "map_id": "none", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10325564", "map_id": "none", "name": "HS(1)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10324079", "map_id": "none", "name": "HGSNAT oligomer acetylates Heparan sulfate chain(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_2090040", "map_id": "CHEBI:63806", "name": "Heparan sulfate chain(3)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090069", "map_id": "CHEBI:63807", "name": "Heparan sulfate chain(4)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10324076", "map_id": "none", "name": "HGSNAT oligomer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "A0A6I8PYT1", "map_id": "A0A6I8PYT1", "name": "hgsnat", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036665", "map_id": "ENSXETG00000036665", "name": "hgsnat", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325961", "map_id": "none", "name": "IDUA hydrolyses Heparan sulfate chain(6)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090055", "map_id": "CHEBI:63809", "name": "Heparan sulfate chain(6)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090070", "map_id": "CHEBI:63810", "name": "Heparan sulfate chain(7)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1678617", "map_id": "CHEBI:28481", "name": "aldehydo-L-iduronic acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10324111", "map_id": "A0A6I8RGH2", "name": "idua", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "ENSXETG00000031913", "map_id": "ENSXETG00000031913", "name": "idua", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325963", "map_id": "none", "name": "HGSNAT oligomer acetylates Heparan chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_2090045", "map_id": "CHEBI:63811", "name": "Heparan chain(1)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090053", "map_id": "CHEBI:63645", "name": "Heparan chain(2)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10325601", "map_id": "none", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10324093", "map_id": "none", "name": "HS/HPIN-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10323951", "map_id": "none", "name": "HS/HPIN-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10324114", "map_id": "none", "name": "IDUA hydrolyses Heparan sulfate chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090033", "map_id": "CHEBI:63666", "name": "Heparan sulfate chain(1)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090072", "map_id": "CHEBI:63805", "name": "Heparan sulfate chain(2)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10337912", "map_id": "none", "name": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1889970", "map_id": "CHEBI:17200", "name": "UDP-GlcA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10324414", "map_id": "none", "name": "Gal-Gal-Xyl-proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "A0A6I8Q003", "map_id": "A0A6I8Q003", "name": "ncan", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000014328", "map_id": "ENSXETG00000014328", "name": "ncan", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A4IIC2", "map_id": "A4IIC2", "name": "dcn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000063928", "map_id": "ENSXETT00000063928", "name": "dcn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PV84", "map_id": "A0A6I8PV84", "name": "D2,4,4(S)3-CSPG4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000015273", "map_id": "ENSXETG00000015273", "name": "D2,4,4(S)3-CSPG4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10324442", "map_id": "none", "name": "GlcA-Gal-Gal-Xyl-proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10324448", "map_id": "none", "name": "B3GAT3:Mn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "F7DRX3", "map_id": "F7DRX3", "name": "b3gat1l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000049772", "map_id": "ENSXETT00000049772", "name": "b3gat1l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324451", "map_id": "none", "name": "B3GAT dimers transfer GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10324386", "map_id": "none", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10324351", "map_id": "none", "name": "GAG core proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_742361", "map_id": "CHEBI:16082", "name": "UDP-Xyl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10324379", "map_id": "none", "name": "xylosyl-core proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10324383", "map_id": "A0A6I8Q7D0", "name": "xylt2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000006839", "map_id": "ENSXETG00000006839", "name": "xylt2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325917", "map_id": "none", "name": "Extracellular KSPG translocates to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10325889", "map_id": "A0A6I8SFJ2", "name": "omd", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000040260", "map_id": "ENSXETG00000040260", "name": "omd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10324223", "map_id": "A0A6I8SFJ2", "name": "omd", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10325932", "map_id": "none", "name": "The keratan chain can be capped by N-acetylneuraminic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_727815", "map_id": "CHEBI:16556", "name": "CMP-Neu5Ac", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10325925", "map_id": "A0A6I8SFJ2", "name": "omd", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10325894", "map_id": "A0A6I8SFJ2", "name": "omd", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10325929", "map_id": "A0A6I8Q4Z5", "name": "st3gal6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000026104", "map_id": "ENSXETG00000026104", "name": "st3gal6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325774", "map_id": "none", "name": "B4GALTs transfer Gal to the N-glycan precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10325769", "map_id": "A0A6I8SFJ2", "name": "omd", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10325772", "map_id": "A0A6I8SFJ2", "name": "omd", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10320782", "map_id": "none", "name": "B4GALT3 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "A0A6I8QS90", "map_id": "A0A6I8QS90", "name": "b4galt3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034513", "map_id": "ENSXETG00000034513", "name": "b4galt3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325934", "map_id": "none", "name": "B4GALTs transfer Gal to a branch of keratan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10325920", "map_id": "A0A6I8SFJ2", "name": "omd", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10325915", "map_id": "none", "name": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10325885", "map_id": "A0A6I8SFJ2", "name": "omd", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10325912", "map_id": "none", "name": "CHST2,5,6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "A0A6I8Q6E3", "map_id": "A0A6I8Q6E3", "name": "chst5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PUA8", "map_id": "A0A6I8PUA8", "name": "CHST6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034141", "map_id": "ENSXETG00000034141", "name": "CHST6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325780", "map_id": "none", "name": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10325777", "map_id": "A0A6I8SFJ2", "name": "omd", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10320403", "map_id": "A0A6I8SXK5", "name": "B3GNT3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10325891", "map_id": "none", "name": "KSPG is secreted from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10325887", "map_id": "A0A6I8SFJ2", "name": "omd", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10325922", "map_id": "none", "name": "B4GALTs transfer Gal to the keratan chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10326060", "map_id": "none", "name": "HYAL1 hydrolyses (HA)50", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2160864", "map_id": "none", "name": "(HA)50", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_2142867", "map_id": "CHEBI:64024", "name": "GlcA-b1,3-GlcNAc", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_2160866", "map_id": "none", "name": "(HA)2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10324215", "map_id": "A0A6I8SP25", "name": "hyal1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "ENSXETG00000040650", "map_id": "ENSXETG00000040650", "name": "hyal1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326088", "map_id": "none", "name": "Receptor-mediated uptake of HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10326064", "map_id": "A0A6I8QK29", "name": "hyal2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000035220", "map_id": "ENSXETG00000035220", "name": "hyal2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326068", "map_id": "F7EIX5", "name": "lyve1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000004761", "map_id": "ENSXETT00000004761", "name": "lyve1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2160848", "map_id": "none", "name": "HA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10326070", "map_id": "none", "name": "HA:HAR:HYAL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F7EIX5", "map_id": "F7EIX5", "name": "lyve1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QK29", "map_id": "A0A6I8QK29", "name": "hyal2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326086", "map_id": "none", "name": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10326083", "map_id": "none", "name": "HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q6DK70", "map_id": "Q6DK70", "name": "phospho-chp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000057366", "map_id": "ENSXETT00000057366", "name": "phospho-chp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2160894", "map_id": "none", "name": "(HA)50", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10331295", "map_id": "none", "name": "CEMIP hydrolyses HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_5693343", "map_id": "CHEBI:64024", "name": "GlcA-b1,3-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10331292", "map_id": "A0A6I8QDU6", "name": "cemip", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000012981", "map_id": "ENSXETG00000012981", "name": "cemip", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326058", "map_id": "none", "name": "HAS1,2,3 mediate the polymerisation of HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_2142896", "map_id": "none", "name": "HA polymer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10326055", "map_id": "B1WB39", "name": "has1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000004083", "map_id": "ENSXETG00000004083", "name": "has1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325597", "map_id": "none", "name": "CSPG is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10325595", "map_id": "none", "name": "CSPGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10324884", "map_id": "none", "name": "CSPGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10324604", "map_id": "none", "name": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10324544", "map_id": "none", "name": "chondroitin(1)-core proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10324594", "map_id": "none", "name": "chondroitin(2)-core proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10324598", "map_id": "A0A6I8PKT3", "name": "CHSY3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000030580", "map_id": "ENSXETG00000030580", "name": "CHSY3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324796", "map_id": "none", "name": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10324555", "map_id": "none", "name": "chondroitin(3)-core proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10324789", "map_id": "none", "name": "C6S-PG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10324793", "map_id": "A0A6I8Q5E8", "name": "chst3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000032713", "map_id": "ENSXETG00000032713", "name": "chst3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324601", "map_id": "none", "name": "CHPF,CHSY3 transfer GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10324778", "map_id": "none", "name": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10324566", "map_id": "none", "name": "C4S-PG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10324771", "map_id": "none", "name": "CSE-PG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10324775", "map_id": "F7AJ35", "name": "cox6b1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETT00000038652", "map_id": "ENSXETT00000038652", "name": "cox6b1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337892", "map_id": "none", "name": "CHSY1 transfers GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10337886", "map_id": "A0A6I8QB22", "name": "chsy1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000018744", "map_id": "ENSXETG00000018744", "name": "chsy1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324583", "map_id": "none", "name": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10324580", "map_id": "none", "name": "CHST9,11,12,13", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q28E26", "map_id": "Q28E26", "name": "chst12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000079954", "map_id": "ENSXETT00000079954", "name": "chst12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q0S9", "map_id": "A0A6I8Q0S9", "name": "chst11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000001882", "map_id": "ENSXETG00000001882", "name": "chst11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PMV5", "map_id": "A0A6I8PMV5", "name": "chst8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000027548", "map_id": "ENSXETG00000027548", "name": "chst8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337889", "map_id": "none", "name": "CHSY1 transfers GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10324829", "map_id": "none", "name": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10324798", "map_id": "none", "name": "DSE,DSEL substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10324822", "map_id": "none", "name": "DSE,DSEL products", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10324826", "map_id": "B1H189", "name": "dse", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETT00000066016", "map_id": "ENSXETT00000066016", "name": "dse", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324954", "map_id": "none", "name": "DSPGs are secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10324952", "map_id": "none", "name": "DSPGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10324858", "map_id": "none", "name": "DSPGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10324218", "map_id": "none", "name": "HYAL1 hydrolyses Chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2065257", "map_id": "none", "name": "Chondroitin chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "CHEBI:63512", "map_id": "CHEBI:63512", "name": "CHEBI:63512", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:63513", "map_id": "CHEBI:63513", "name": "CHEBI:63513", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:63515", "map_id": "CHEBI:63515", "name": "CHEBI:63515", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:63511", "map_id": "CHEBI:63511", "name": "CHEBI:63511", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2065212", "map_id": "CHEBI:63505", "name": "CS/HS precursor", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10324211", "map_id": "none", "name": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2105025", "map_id": "CHEBI:63873", "name": "IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xyl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2104993", "map_id": "CHEBI:63868", "name": "CHEBI:63868 chain", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10324930", "map_id": "none", "name": "DSPG and CSPG translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10324928", "map_id": "none", "name": "DSPGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10324910", "map_id": "none", "name": "CSPGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10330365", "map_id": "none", "name": "SORD tetramer oxidizes xylitol to D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5660033", "map_id": "CHEBI:17151", "name": "xylitol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5661281", "map_id": "CHEBI:17140", "name": "D-xylulose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10330362", "map_id": "none", "name": "AKR1A1 reduces D-glucuronate to L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5661264", "map_id": "CHEBI:15748", "name": "D-glucuronate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5661268", "map_id": "CHEBI:13115", "name": "L-gulonate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10311741", "map_id": "none", "name": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29882", "map_id": "CHEBI:15721", "name": "SH7P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29878", "map_id": "CHEBI:16897", "name": "E4P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311738", "map_id": "none", "name": "TALDO1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SUP4", "map_id": "A0A6I8SUP4", "name": "LOC108644521", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000025887", "map_id": "ENSXETG00000025887", "name": "LOC108644521", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311732", "map_id": "none", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31467", "map_id": "CHEBI:16938", "name": "D-Glucono-1,5-lactone 6-phosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29996", "map_id": "CHEBI:16863", "name": "PDG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311729", "map_id": "A0A6I8QGW7", "name": "pgls", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000038389", "map_id": "ENSXETG00000038389", "name": "pgls", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335154", "map_id": "none", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_8853719", "map_id": "CHEBI:71553", "name": "GlcNAc:Man", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1678743", "map_id": "CHEBI:17411", "name": "GlcNAc", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_6799594", "map_id": "CHEBI:4208", "name": "Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10335151", "map_id": "A0A6I8SFY1", "name": "manba", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "ENSXETG00000002247", "map_id": "ENSXETG00000002247", "name": "manba", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337628", "map_id": "none", "name": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9033793", "map_id": "CHEBI:139351", "name": "H antigen-RBC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9033802", "map_id": "CHEBI:139352", "name": "A antigen-RBC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10337625", "map_id": "none", "name": "ABO-A:Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "A0A6I8SLE8", "map_id": "A0A6I8SLE8", "name": "LOC100491742", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038208", "map_id": "ENSXETG00000038208", "name": "LOC100491742", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337694", "map_id": "none", "name": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9036984", "map_id": "CHEBI:140162", "name": "Type 1 chain", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_205683", "map_id": "CHEBI:17009", "name": "GDP-Fuc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_205689", "map_id": "CHEBI:17552", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9037036", "map_id": "CHEBI:140180", "name": "H antigen-sec", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10337691", "map_id": "A0A6I8RP86", "name": "FUT2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000041078", "map_id": "ENSXETG00000041078", "name": "FUT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337646", "map_id": "none", "name": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9034101", "map_id": "CHEBI:140180", "name": "H antigen-sec", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_9034046", "map_id": "CHEBI:16650", "name": "UDP-GalNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_9037066", "map_id": "CHEBI:140186", "name": "A antigen-sec", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10337643", "map_id": "none", "name": "sABO-A:Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10337653", "map_id": "none", "name": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9034065", "map_id": "CHEBI:18307", "name": "UDP-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_9037067", "map_id": "CHEBI:140187", "name": "B antigen-sec", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10337650", "map_id": "none", "name": "sABO-B:Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10337639", "map_id": "none", "name": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9033798", "map_id": "CHEBI:139353", "name": "B antigen-RBC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10337636", "map_id": "none", "name": "ABO-B:Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10337619", "map_id": "none", "name": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9033790", "map_id": "CHEBI:139350", "name": "Type 2 chain", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10337616", "map_id": "A0A6I8RP86", "name": "FUT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10337740", "map_id": "none", "name": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605685", "map_id": "CHEBI:140918", "name": "Type 2 MSGG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10337743", "map_id": "none", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605595", "map_id": "CHEBI:140917", "name": "Type 1 MSGG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605615", "map_id": "CHEBI:140914", "name": "sLeA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10331319", "map_id": "A0A6I8PQF9", "name": "fut7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000032714", "map_id": "ENSXETG00000032714", "name": "fut7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337721", "map_id": "none", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605593", "map_id": "CHEBI:140911", "name": "LeX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10337718", "map_id": "none", "name": "FUT4,5,9(10,11)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "A0A6I8PN52", "map_id": "A0A6I8PN52", "name": "FUT9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037458", "map_id": "ENSXETG00000037458", "name": "FUT9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PQF9", "map_id": "A0A6I8PQF9", "name": "fut7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337736", "map_id": "none", "name": "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9604808", "map_id": "CHEBI:140876", "name": "GlcNAc-\u03b21,3-Gal-R", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10337733", "map_id": "none", "name": "Homologues of B3GALT5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "A0A6I8PS91", "map_id": "A0A6I8PS91", "name": "B3GALT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040256", "map_id": "ENSXETG00000040256", "name": "B3GALT5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PVV6", "map_id": "A0A6I8PVV6", "name": "B3GALT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337723", "map_id": "none", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605607", "map_id": "CHEBI:140878", "name": "LeA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10337749", "map_id": "none", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605661", "map_id": "CHEBI:140916", "name": "sLeX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10337700", "map_id": "none", "name": "FUT2 transfers Fuc to LeX to form LeY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605586", "map_id": "CHEBI:140912", "name": "LeY", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10337751", "map_id": "none", "name": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605718", "map_id": "CHEBI:140913", "name": "Sda", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10335255", "map_id": "A0A6I8QM48", "name": "B4GALNT2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000033376", "map_id": "ENSXETG00000033376", "name": "B4GALNT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337745", "map_id": "none", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605649", "map_id": "CHEBI:140919", "name": "Type 1 DSGG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605651", "map_id": "CHEBI:140915", "name": "dsLeA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10337698", "map_id": "none", "name": "FUT2 transfers Fuc to LeA to form LeB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605394", "map_id": "CHEBI:140910", "name": "LeB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10322454", "map_id": "none", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113531", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10322452", "map_id": "none", "name": "FXN:ISD11:NFS1:ISCU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A0A6I8R145", "map_id": "A0A6I8R145", "name": "fxn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039175", "map_id": "ENSXETG00000039175", "name": "fxn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q5L5", "map_id": "A0A6I8Q5L5", "name": "lyrm4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038488", "map_id": "ENSXETG00000038488", "name": "lyrm4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6P633", "map_id": "Q6P633", "name": "iscu", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000057208", "map_id": "ENSXETT00000057208", "name": "iscu", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10322436", "map_id": "none", "name": "2 Iron:FXN:NFS1:ISD11:ISCU", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10322449", "map_id": "none", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_379721", "map_id": "CHEBI:35235", "name": "L-Cys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10322442", "map_id": "none", "name": "FDX1 (red.)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:33738", "map_id": "CHEBI:33738", "name": "CHEBI:33738", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7CAB2", "map_id": "F7CAB2", "name": "fdx1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000030454", "map_id": "ENSXETT00000030454", "name": "fdx1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_379697", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10322446", "map_id": "none", "name": "FDX1 (ox.)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:33737", "map_id": "CHEBI:33737", "name": "CHEBI:33737", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10322444", "map_id": "none", "name": "FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:33739", "map_id": "CHEBI:33739", "name": "CHEBI:33739", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336048", "map_id": "none", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10336040", "map_id": "none", "name": "ISCA1:ISCA2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A0A6I8PNK1", "map_id": "A0A6I8PNK1", "name": "isca2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031871", "map_id": "ENSXETG00000031871", "name": "isca2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PY88", "map_id": "A0A6I8PY88", "name": "isca1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000030839", "map_id": "ENSXETG00000030839", "name": "isca1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10336030", "map_id": "none", "name": "GLRX5:2Fe-2S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q6DJ11", "map_id": "Q6DJ11", "name": "glrx5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000054920", "map_id": "ENSXETT00000054920", "name": "glrx5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10336042", "map_id": "none", "name": "ISCA1:ISCA2:4Fe-4S", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:49883", "map_id": "CHEBI:49883", "name": "CHEBI:49883", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10336028", "map_id": "Q6DJ11", "name": "glrx5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10336046", "map_id": "A0A6I8PSW4", "name": "hscb", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "ENSXETG00000026948", "map_id": "ENSXETG00000026948", "name": "hscb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317263", "map_id": "none", "name": "Potassium voltage-gated channels close in reponse to PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10317261", "map_id": "none", "name": "Potassium voltage-gated channels (beta cell, open)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PNT1", "map_id": "A0A6I8PNT1", "name": "kcnc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000032745", "map_id": "ENSXETG00000032745", "name": "kcnc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PSS9", "map_id": "A0A6I8PSS9", "name": "kcns3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000015573", "map_id": "ENSXETG00000015573", "name": "kcns3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317251", "map_id": "none", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10317243", "map_id": "none", "name": "Ca-channel (closed)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "F6XEN8", "map_id": "F6XEN8", "name": "nrxn1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000003958", "map_id": "ENSXETT00000003958", "name": "nrxn1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QV43", "map_id": "A0A6I8QV43", "name": "itpr1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000005153", "map_id": "ENSXETG00000005153", "name": "itpr1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317249", "map_id": "none", "name": "Ca-channel (open)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_114520", "map_id": "CHEBI:16595", "name": "I(1,4,5)P3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10317267", "map_id": "none", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10317265", "map_id": "none", "name": "RAP1A:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q640R7", "map_id": "Q640R7", "name": "rap1b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000104159", "map_id": "ENSXETT00000104159", "name": "rap1b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10316760", "map_id": "none", "name": "RAP1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10335625", "map_id": "none", "name": "HSD17B13 binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10331297", "map_id": "A8WGW3", "name": "LOC613063", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000002941", "map_id": "ENSXETT00000002941", "name": "LOC613063", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8866926", "map_id": "none", "name": "lipid droplet", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "true" }, { "id": "species_10335623", "map_id": "none", "name": "HSD17B13:lipid droplet", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "true" }, { "id": "A8WGW3", "map_id": "A8WGW3", "name": "LOC613063", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335344", "map_id": "none", "name": "FITM1, FITM2 bind TAGs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_549167", "map_id": "CHEBI:17855", "name": "TAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10335340", "map_id": "A0JP80", "name": "fitm2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000001773", "map_id": "ENSXETG00000001773", "name": "fitm2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335342", "map_id": "none", "name": "(FITM1,FITM2):TAGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0JP80", "map_id": "A0JP80", "name": "fitm2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10331439", "map_id": "none", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5696122", "map_id": "CHEBI:52575", "name": "alkylglycerol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76116", "map_id": "CHEBI:17754", "name": "Glycerol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5696116", "map_id": "CHEBI:35746", "name": "fatty aldehyde", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10331436", "map_id": "Q5M8F9", "name": "agmo", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000005052", "map_id": "ENSXETG00000005052", "name": "agmo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10333674", "map_id": "none", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6800352", "map_id": "CHEBI:17389", "name": "2AG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1500578", "map_id": "CHEBI:17984", "name": "acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76103", "map_id": "CHEBI:17815", "name": "DAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10333671", "map_id": "none", "name": "MOGAT1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q5M8H5", "map_id": "Q5M8H5", "name": "mogat2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000008697", "map_id": "ENSXETT00000008697", "name": "mogat2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28C88", "map_id": "Q28C88", "name": "mogat1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000002935", "map_id": "ENSXETG00000002935", "name": "mogat1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10319045", "map_id": "none", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_75967", "map_id": "CHEBI:37554", "name": "FACoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10319042", "map_id": "Q6P342", "name": "dgat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000025317", "map_id": "ENSXETG00000025317", "name": "dgat2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323897", "map_id": "none", "name": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429807", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1606609", "map_id": "CHEBI:16393", "name": "SPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1861754", "map_id": "CHEBI:33575", "name": "RCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10323894", "map_id": "none", "name": "ASAH2-like proteins", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10323915", "map_id": "none", "name": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_428270", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_1660674", "map_id": "CHEBI:18368", "name": "Glucosylceramide", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10323912", "map_id": "Q5BL38", "name": "ugcg", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETT00000084396", "map_id": "ENSXETT00000084396", "name": "ugcg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329573", "map_id": "none", "name": "GLTPD1 transports C1P from plasma membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1638840", "map_id": "CHEBI:16197", "name": "C1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_5339515", "map_id": "CHEBI:16197", "name": "C1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10329570", "map_id": "Q66JG2", "name": "cptp", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000024361", "map_id": "ENSXETT00000024361", "name": "cptp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323888", "map_id": "none", "name": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1606573", "map_id": "CHEBI:18390", "name": "GalCer", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605673", "map_id": "CHEBI:52639", "name": "CERA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10323885", "map_id": "Q0VA39", "name": "galc", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "ENSXETG00000016608", "map_id": "ENSXETG00000016608", "name": "galc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323922", "map_id": "none", "name": "CERK phosphorylates CERA to form C1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10323919", "map_id": "A0A6I8PSC9", "name": "XB5892679", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000030525", "map_id": "ENSXETG00000030525", "name": "XB5892679", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318077", "map_id": "none", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428206", "map_id": "none", "name": "NAD(P)H", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_428126", "map_id": "CHEBI:31488", "name": "DHCE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_428218", "map_id": "none", "name": "NAD(P)+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_428256", "map_id": "CHEBI:17761", "name": "CERA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10318074", "map_id": "Q68FB8", "name": "degs1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETT00000040228", "map_id": "ENSXETT00000040228", "name": "degs1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318094", "map_id": "none", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428203", "map_id": "CHEBI:37550", "name": "S1P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_428682", "map_id": "CHEBI:16393", "name": "SPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10318088", "map_id": "A0A6I8Q393", "name": "sgpp2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000030642", "map_id": "ENSXETG00000030642", "name": "sgpp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318091", "map_id": "none", "name": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428275", "map_id": "CHEBI:16893", "name": "SPAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_428694", "map_id": "CHEBI:16566", "name": "SPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10336999", "map_id": "none", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8959463", "map_id": "CHEBI:73204", "name": "CPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10336996", "map_id": "F6PVR7", "name": "SAMD8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETT00000042961", "map_id": "ENSXETT00000042961", "name": "SAMD8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318070", "map_id": "none", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428139", "map_id": "CHEBI:15541", "name": "ST-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_428163", "map_id": "CHEBI:16566", "name": "SPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10318067", "map_id": "F6ZH52", "name": "cers5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETT00000029263", "map_id": "ENSXETT00000029263", "name": "cers5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10331218", "map_id": "none", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_428671", "map_id": "CHEBI:17585", "name": "HD2NAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10331215", "map_id": "none", "name": "ALDH3A2-1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "F6X8Y6", "map_id": "F6X8Y6", "name": "aldh3a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314156", "map_id": "none", "name": "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191409", "map_id": "CHEBI:17211", "name": "GPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191362", "map_id": "CHEBI:16584", "name": "IPPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191385", "map_id": "CHEBI:17407", "name": "FAPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10314153", "map_id": "none", "name": "2(FDPS:3Mg2+)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8QKN8", "map_id": "A0A6I8QKN8", "name": "fdps", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040625", "map_id": "ENSXETG00000040625", "name": "fdps", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314159", "map_id": "none", "name": "Addition of isopentenyl pyrophosphate to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191324", "map_id": "CHEBI:16057", "name": "DMAPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10314175", "map_id": "none", "name": "Squalene 2,3-epoxide cyclizes, forming lanosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191309", "map_id": "CHEBI:15441", "name": "SQOX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_194634", "map_id": "CHEBI:16521", "name": "LNSOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10314172", "map_id": "F6S007", "name": "fcrl3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETT00000043201", "map_id": "ENSXETT00000043201", "name": "fcrl3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314168", "map_id": "none", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191374", "map_id": "CHEBI:15467", "name": "bHMG-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191424", "map_id": "CHEBI:17710", "name": "MVA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10314165", "map_id": "none", "name": "HMGCR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A6I8REP9", "map_id": "A0A6I8REP9", "name": "hmgcr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000005084", "map_id": "ENSXETG00000005084", "name": "hmgcr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314315", "map_id": "none", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_194681", "map_id": "CHEBI:17813", "name": "4,4DMCHtOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_194725", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_194688", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_194668", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_194704", "map_id": "CHEBI:18364", "name": "14DMLANOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10314312", "map_id": "A0A6I8R8E2", "name": "LBR", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "ENSXETG00000034786", "map_id": "ENSXETG00000034786", "name": "LBR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329482", "map_id": "none", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_171095", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10329479", "map_id": "B7ZSL6", "name": "arv1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETT00000055609", "map_id": "ENSXETT00000055609", "name": "arv1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314344", "map_id": "none", "name": "Reduction of desmosterol to cholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196420", "map_id": "CHEBI:17737", "name": "DESMOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10314337", "map_id": "none", "name": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_195655", "map_id": "CHEBI:27910", "name": "7dhDESOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10314322", "map_id": "none", "name": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_195691", "map_id": "CHEBI:16290", "name": "CHdOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10336886", "map_id": "none", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191265", "map_id": "CHEBI:15442", "name": "PSQPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8952135", "map_id": "CHEBI:134117", "name": "presqualene monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10336883", "map_id": "F7BMI1", "name": "plpp6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000041334", "map_id": "ENSXETT00000041334", "name": "plpp6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335903", "map_id": "none", "name": "STARD5 binds DCA, LCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10335899", "map_id": "A0A6I8PZC4", "name": "stard5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000030995", "map_id": "ENSXETG00000030995", "name": "stard5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5357505", "map_id": "CHEBI:28834", "name": "DCA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10335901", "map_id": "none", "name": "STARD5:DCA,LCA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8PZC4", "map_id": "A0A6I8PZC4", "name": "stard5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10313015", "map_id": "none", "name": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194073", "map_id": "none", "name": "choloyl-CoA; chenodeoxycholoyl-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_192356", "map_id": "CHEBI:15519", "name": "choloyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193472", "map_id": "CHEBI:28701", "name": "chenodeoxycholoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_194069", "map_id": "none", "name": "glycine; taurine", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_193416", "map_id": "none", "name": "bile salts", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:17687", "map_id": "CHEBI:17687", "name": "CHEBI:17687", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:36274", "map_id": "CHEBI:36274", "name": "CHEBI:36274", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16525", "map_id": "CHEBI:16525", "name": "CHEBI:16525", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28865", "map_id": "CHEBI:28865", "name": "CHEBI:28865", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10313012", "map_id": "F6UBG9", "name": "acot2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000000095", "map_id": "ENSXETT00000000095", "name": "acot2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335837", "map_id": "none", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8868399", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8868400", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10335834", "map_id": "none", "name": "OSBPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q0IJ05", "map_id": "Q0IJ05", "name": "osbpl9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000002831", "map_id": "ENSXETG00000002831", "name": "osbpl9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SCX9", "map_id": "A0A6I8SCX9", "name": "osbpl6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000015011", "map_id": "ENSXETG00000015011", "name": "osbpl6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314190", "map_id": "none", "name": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_192078", "map_id": "CHEBI:16496", "name": "5bCHOL3a,7a,12a-triol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_192201", "map_id": "CHEBI:17278", "name": "5bCHOL3a,7a,12a,27-tetrol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10314213", "map_id": "none", "name": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_191968", "map_id": "CHEBI:16466", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10314261", "map_id": "none", "name": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193463", "map_id": "none", "name": "glycine; taurine", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "species_193453", "map_id": "none", "name": "chenodeoxycholate bile salts", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "species_193514", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10314228", "map_id": "F6UBG9", "name": "acot2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10314263", "map_id": "none", "name": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_193387", "map_id": "CHEBI:28540", "name": "5beta-cholestan-3alpha,7alpha,26-triol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_193435", "map_id": "CHEBI:27428", "name": "3alpha,7alpha-dihydroxy-5beta-cholestan-26-al", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10314215", "map_id": "none", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_192161", "map_id": "CHEBI:18402", "name": "THCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10314231", "map_id": "none", "name": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193404", "map_id": "none", "name": "cholate bile salts", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10314257", "map_id": "none", "name": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_193436", "map_id": "CHEBI:28047", "name": "5beta-cholestan-3alpha, 7alpha-diol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10314211", "map_id": "none", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192064", "map_id": "CHEBI:2288", "name": "5beta-cholesten-7alpha, 12alpha-diol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_192087", "map_id": "CHEBI:16496", "name": "5beta-cholestan-3alpha,7alpha,12alpha-triol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10314208", "map_id": "none", "name": "Aldo-keto reductase family", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SP23", "map_id": "A0A6I8SP23", "name": "LOC100494522", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000041302", "map_id": "ENSXETG00000041302", "name": "LOC100494522", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RTD2", "map_id": "A0A6I8RTD2", "name": "LOC101733893", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038578", "map_id": "ENSXETG00000038578", "name": "LOC101733893", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314259", "map_id": "none", "name": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_193440", "map_id": "CHEBI:16577", "name": "DHCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10314226", "map_id": "none", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191980", "map_id": "CHEBI:2290", "name": "5beta-cholestan-7alpha-ol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_192030", "map_id": "CHEBI:28047", "name": "5beta-cholestan-3alpha,7alpha-diol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10335848", "map_id": "none", "name": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1806217", "map_id": "CHEBI:17526", "name": "PI4P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_8868393", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_1806234", "map_id": "CHEBI:17526", "name": "PI4P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10335845", "map_id": "A0A6I8RP96", "name": "osbp", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000020714", "map_id": "ENSXETG00000020714", "name": "osbp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314269", "map_id": "none", "name": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_193708", "map_id": "CHEBI:63833", "name": "5bCHOL3a,7a,24(s),27-tetrol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_193716", "map_id": "CHEBI:63848", "name": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10314271", "map_id": "none", "name": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_193757", "map_id": "CHEBI:48736", "name": "3,7,24THCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10314281", "map_id": "none", "name": "CYP27A1 27-hydroxylates 5-CHOL3,7,24(s)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_193720", "map_id": "CHEBI:63831", "name": "5\u03b2-CHOL3\u03b1,7\u03b1,24(s)-triol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10314267", "map_id": "none", "name": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_193785", "map_id": "CHEBI:63849", "name": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_193747", "map_id": "CHEBI:63824", "name": "TetraHCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10314277", "map_id": "none", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193707", "map_id": "CHEBI:63830", "name": "5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193728", "map_id": "CHEBI:63834", "name": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10314279", "map_id": "none", "name": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_193777", "map_id": "CHEBI:63834", "name": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_193782", "map_id": "CHEBI:63835", "name": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10314273", "map_id": "none", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193760", "map_id": "CHEBI:63829", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_213285", "map_id": "CHEBI:63831", "name": "5beta-cholestan-3alpha,7alpha,24(S)-triol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10314275", "map_id": "none", "name": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10314285", "map_id": "none", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193830", "map_id": "CHEBI:48778", "name": "5beta-cholestan-7alpha,27-diol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193842", "map_id": "CHEBI:28540", "name": "5beta-cholestan-3alpha,7alpha,26-triol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10314283", "map_id": "none", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193829", "map_id": "CHEBI:48834", "name": "5beta-cholestan-7alpha,12alpha,27-triol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193843", "map_id": "CHEBI:17278", "name": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10331300", "map_id": "none", "name": "HSD17B11 dehydrogenates EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193066", "map_id": "CHEBI:17263", "name": "E1", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10334610", "map_id": "none", "name": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176619", "map_id": "CHEBI:16469", "name": "E2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10334607", "map_id": "none", "name": "HSD17B14 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8S4B9", "map_id": "A0A6I8S4B9", "name": "hsd17b14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035086", "map_id": "ENSXETG00000035086", "name": "hsd17b14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314330", "map_id": "none", "name": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10314328", "map_id": "none", "name": "STAR:CHOL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "F7C998", "map_id": "F7C998", "name": "tmem221", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000006725", "map_id": "ENSXETT00000006725", "name": "tmem221", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10314326", "map_id": "F7C998", "name": "tmem221", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_193156", "map_id": "CHEBI:16113", "name": "CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10338216", "map_id": "none", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193057", "map_id": "CHEBI:17347", "name": "TEST", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_469662", "map_id": "CHEBI:16330", "name": "DHTEST", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10338213", "map_id": "none", "name": "SRD5A2 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10338210", "map_id": "A0A6I8PNY4", "name": "srd5a2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000025082", "map_id": "ENSXETG00000025082", "name": "srd5a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314308", "map_id": "none", "name": "HSD11B2,HSD11B1 dimer oxidise CORT to COR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_193977", "map_id": "CHEBI:17650", "name": "CORT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_194035", "map_id": "CHEBI:16962", "name": "COR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10314305", "map_id": "none", "name": "HSD11B1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A4IGM4", "map_id": "A4IGM4", "name": "hsd11b1l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000031363", "map_id": "ENSXETT00000031363", "name": "hsd11b1l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10322500", "map_id": "none", "name": "Corticosteroids bind to CBG in blood", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1449707", "map_id": "none", "name": "Corticosteroids", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:17026", "map_id": "CHEBI:17026", "name": "CHEBI:17026", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10322496", "map_id": "none", "name": "Homologues of SERPINA6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8S033", "map_id": "A0A6I8S033", "name": "LOC100488834", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000009423", "map_id": "ENSXETG00000009423", "name": "LOC100488834", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6SYS3", "map_id": "F6SYS3", "name": "SERPINA6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000046350", "map_id": "ENSXETT00000046350", "name": "SERPINA6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QL92", "map_id": "A0A6I8QL92", "name": "LOC105948230", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039008", "map_id": "ENSXETG00000039008", "name": "LOC105948230", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10322498", "map_id": "none", "name": "CBG:Corticosteroids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10319038", "map_id": "none", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_548812", "map_id": "CHEBI:50571", "name": "3OOD-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548836", "map_id": "CHEBI:50583", "name": "3HODC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10319035", "map_id": "Q28IU1", "name": "hsd17b12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETT00000048094", "map_id": "ENSXETT00000048094", "name": "hsd17b12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10315643", "map_id": "none", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10315640", "map_id": "A0A6I8QXS3", "name": "acsl6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000016588", "map_id": "ENSXETG00000016588", "name": "acsl6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10319031", "map_id": "none", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29508", "map_id": "CHEBI:15531", "name": "Mal-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10319028", "map_id": "A0A6I8QSB1", "name": "ELOVL6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000035907", "map_id": "ENSXETG00000035907", "name": "ELOVL6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10319024", "map_id": "none", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_548819", "map_id": "CHEBI:15514", "name": "AA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548816", "map_id": "CHEBI:63821", "name": "3ODCT-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10330576", "map_id": "none", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5676631", "map_id": "CHEBI:15456", "name": "VLC3HA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5676634", "map_id": "CHEBI:50998", "name": "2,3-TE-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10330573", "map_id": "none", "name": "PTPLs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A6I8T2J8", "map_id": "A0A6I8T2J8", "name": "hacd2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040752", "map_id": "ENSXETG00000040752", "name": "hacd2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334601", "map_id": "none", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6810523", "map_id": "CHEBI:37554", "name": "FA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6809360", "map_id": "CHEBI:37240", "name": "3',5'-ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6810530", "map_id": "CHEBI:47983", "name": "acyl-PPANT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10334598", "map_id": "F7C9X4", "name": "nudt19", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "ENSXETT00000054418", "map_id": "ENSXETT00000054418", "name": "nudt19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334696", "map_id": "none", "name": "ACBD4,5 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_5690520", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "CHEBI:33184", "map_id": "CHEBI:33184", "name": "CHEBI:33184", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:61907", "map_id": "CHEBI:61907", "name": "CHEBI:61907", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10334692", "map_id": "none", "name": "ACBD5,(ACBD4)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q640U0", "map_id": "Q640U0", "name": "acbd5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000040674", "map_id": "ENSXETT00000040674", "name": "acbd5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10334694", "map_id": "none", "name": "ACBD4,5:LCFA-CoA, MCFA-CoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10317404", "map_id": "none", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_390394", "map_id": "CHEBI:52966", "name": "C26:0 CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_390260", "map_id": "CHEBI:52966", "name": "C26:0 CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10317281", "map_id": "none", "name": "ABCD1 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "A0A6I8Q353", "map_id": "A0A6I8Q353", "name": "abcd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10330926", "map_id": "none", "name": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_5690539", "map_id": "none", "name": "MCFA, LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "CHEBI:59554", "map_id": "CHEBI:59554", "name": "CHEBI:59554", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330921", "map_id": "F6UBG9", "name": "acot2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10334585", "map_id": "none", "name": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6809801", "map_id": "CHEBI:85939", "name": "3Z-octenoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6809800", "map_id": "CHEBI:27537", "name": "2E-octenoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10334582", "map_id": "none", "name": "ECI2 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "A0A6I8RBB6", "map_id": "A0A6I8RBB6", "name": "eci3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000032831", "map_id": "ENSXETG00000032831", "name": "eci3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10332329", "map_id": "none", "name": "DECR2 reduces LCtE-CoA to t3enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193465", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6786723", "map_id": "CHEBI:83727", "name": "LCtE-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_113602", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6786715", "map_id": "CHEBI:27700", "name": "t3enoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389556", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10332326", "map_id": "F6TNJ3", "name": "decr2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "ENSXETT00000022727", "map_id": "ENSXETT00000022727", "name": "decr2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334554", "map_id": "none", "name": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390248", "map_id": "CHEBI:64972", "name": "3-hydroxyhexacosanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192307", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390241", "map_id": "CHEBI:52977", "name": "3-ketohexacosanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192305", "map_id": "CHEBI:57945", "name": "NADH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10334548", "map_id": "L7N381", "name": "ehhadh", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "ENSXETT00000023381", "map_id": "ENSXETT00000023381", "name": "ehhadh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334551", "map_id": "none", "name": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390249", "map_id": "CHEBI:52975", "name": "trans-2,3-dehydrohexacosanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10320834", "map_id": "none", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_977323", "map_id": "CHEBI:15531", "name": "Malonyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_353123", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389536", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10320831", "map_id": "A0A6I8RH42", "name": "mlycd", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "ENSXETG00000013233", "map_id": "ENSXETG00000013233", "name": "mlycd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317365", "map_id": "none", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389636", "map_id": "CHEBI:49189", "name": "Pristanal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6811612", "map_id": "CHEBI:77268", "name": "pristanate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10317362", "map_id": "none", "name": "ALDH3A2-2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10317391", "map_id": "none", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389893", "map_id": "CHEBI:64039", "name": "(2S) Pristanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389894", "map_id": "CHEBI:63803", "name": "trans-2,3-dehydropristanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10317388", "map_id": "none", "name": "ACOX3:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "A0A6I8PRN9", "map_id": "A0A6I8PRN9", "name": "acox3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031495", "map_id": "ENSXETG00000031495", "name": "acox3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325882", "map_id": "none", "name": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046059", "map_id": "CHEBI:63539", "name": "EPA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046057", "map_id": "CHEBI:63541", "name": "DPA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10325876", "map_id": "none", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046052", "map_id": "CHEBI:63545", "name": "SDA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046051", "map_id": "CHEBI:63542", "name": "ETA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10325874", "map_id": "none", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046054", "map_id": "CHEBI:63540", "name": "THA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_426639", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_2046047", "map_id": "CHEBI:63540", "name": "THA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10326111", "map_id": "none", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_29768", "map_id": "CHEBI:15843", "name": "AA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2142739", "map_id": "CHEBI:34450", "name": "5,6-EET", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10326116", "map_id": "none", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2161753", "map_id": "none", "name": "8,9/11,12/14,15-EET", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:34130", "map_id": "CHEBI:34130", "name": "CHEBI:34130", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34490", "map_id": "CHEBI:34490", "name": "CHEBI:34490", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34157", "map_id": "CHEBI:34157", "name": "CHEBI:34157", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326113", "map_id": "none", "name": "CYP(5)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10326136", "map_id": "none", "name": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142790", "map_id": "CHEBI:34145", "name": "12R-HpETE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10326133", "map_id": "none", "name": "ALOX12B:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8QVI1", "map_id": "A0A6I8QVI1", "name": "LOC100496875", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000018683", "map_id": "ENSXETG00000018683", "name": "LOC100496875", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R9T5", "map_id": "A0A6I8R9T5", "name": "alox15b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000000004", "map_id": "ENSXETG00000000004", "name": "alox15b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336762", "map_id": "none", "name": "ALOXE3 isomerises 12R-HpETE to HXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8942209", "map_id": "CHEBI:36190", "name": "HXA3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10336759", "map_id": "none", "name": "Homologues of ALOXE3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10331492", "map_id": "none", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_192172", "map_id": "CHEBI:17984", "name": "Acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5696426", "map_id": "CHEBI:75627", "name": "ARACOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5696412", "map_id": "CHEBI:10036", "name": "arachidyl ester", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10331489", "map_id": "Q6P342", "name": "dgat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10326094", "map_id": "none", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_879629", "map_id": "CHEBI:15555", "name": "PGD2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2142710", "map_id": "CHEBI:27595", "name": "11epi-PGF2a", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10314206", "map_id": "none", "name": "Homologues of AKR1C1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8R8Y6", "map_id": "A0A6I8R8Y6", "name": "LOC734139", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040684", "map_id": "ENSXETG00000040684", "name": "LOC734139", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326091", "map_id": "none", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_265283", "map_id": "CHEBI:15554", "name": "PGH2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_879535", "map_id": "CHEBI:15553", "name": "PGF2a", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10326099", "map_id": "none", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10326096", "map_id": "none", "name": "HPGDS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_1247892", "map_id": "CHEBI:16856", "name": "GSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10326143", "map_id": "none", "name": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142718", "map_id": "CHEBI:15628", "name": "15S-HpETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10326140", "map_id": "none", "name": "ALOX15B:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10312563", "map_id": "none", "name": "Hydrolysis of phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_426925", "map_id": "CHEBI:16110", "name": "PC", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_428981", "map_id": "CHEBI:17504", "name": "LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10312558", "map_id": "none", "name": "Active PLA2:phosphatidylcholine", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "B1WAZ6", "map_id": "B1WAZ6", "name": "phospho-pla2g4a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335800", "map_id": "none", "name": "MID1IP1 binds THRSP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10335794", "map_id": "Q6P8B2", "name": "mid1ip1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000087898", "map_id": "ENSXETT00000087898", "name": "mid1ip1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335796", "map_id": "Q6P8B2", "name": "mid1ip1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10335798", "map_id": "none", "name": "MID1IP1:THRSP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6P8B2", "map_id": "Q6P8B2", "name": "mid1ip1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10315632", "map_id": "none", "name": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_201050", "map_id": "CHEBI:17490", "name": "L-PCARN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_201023", "map_id": "CHEBI:17126", "name": "CAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77281", "map_id": "CHEBI:15525", "name": "PalmCoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10315629", "map_id": "Q6P4X5", "name": "cpt2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "ENSXETT00000017686", "map_id": "ENSXETT00000017686", "name": "cpt2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10330939", "map_id": "none", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5690044", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5690064", "map_id": "none", "name": "MCFA, LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10330936", "map_id": "none", "name": "Cytosolic ACOTs, THEM4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6DER5", "map_id": "Q6DER5", "name": "acot13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000054972", "map_id": "ENSXETT00000054972", "name": "acot13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6UBG9", "map_id": "F6UBG9", "name": "acot2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10330950", "map_id": "none", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5690540", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_5690519", "map_id": "none", "name": "MCFA, LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10330947", "map_id": "none", "name": "ACOT2,9, THEM4,5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A0A6I8RQ71", "map_id": "A0A6I8RQ71", "name": "LOC101735170", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036041", "map_id": "ENSXETG00000036041", "name": "LOC101735170", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336900", "map_id": "none", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77343", "map_id": "CHEBI:10723", "name": "tdec2-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77308", "map_id": "CHEBI:28493", "name": "DEC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10336897", "map_id": "none", "name": "MECR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q28GQ2", "map_id": "Q28GQ2", "name": "mecr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000031439", "map_id": "ENSXETT00000031439", "name": "mecr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324062", "map_id": "none", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_202247", "map_id": "CHEBI:16152", "name": "PI(3,4)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1806276", "map_id": "CHEBI:17283", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10324057", "map_id": "A0A6I8SEN5", "name": "inpp4a", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000019407", "map_id": "ENSXETG00000019407", "name": "inpp4a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324025", "map_id": "none", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10324015", "map_id": "A0A6I8RPT3", "name": "synj1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000009899", "map_id": "ENSXETG00000009899", "name": "synj1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323994", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10323991", "map_id": "none", "name": "PI4K2A/2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q28G26", "map_id": "Q28G26", "name": "pi4k2b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000000962", "map_id": "ENSXETG00000000962", "name": "pi4k2b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q505I0", "map_id": "Q505I0", "name": "pi4k2a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000013516", "map_id": "ENSXETG00000013516", "name": "pi4k2a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324053", "map_id": "none", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10324020", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1806224", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10324048", "map_id": "none", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10312068", "map_id": "none", "name": "PI3K", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10323981", "map_id": "none", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1806240", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10323978", "map_id": "none", "name": "PIP4K2C:PIP4K2C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6GL14", "map_id": "Q6GL14", "name": "pip4k2c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000006229", "map_id": "ENSXETG00000006229", "name": "pip4k2c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324043", "map_id": "none", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10324037", "map_id": "none", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10323972", "map_id": "none", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10324070", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10324031", "map_id": "none", "name": "MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8QJY3", "map_id": "A0A6I8QJY3", "name": "mtmr3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000016428", "map_id": "ENSXETG00000016428", "name": "mtmr3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RPT3", "map_id": "A0A6I8RPT3", "name": "synj1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324065", "map_id": "none", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10324034", "map_id": "none", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10324045", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806205", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_1806259", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10323998", "map_id": "F6VED7", "name": "MTMR2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000011460", "map_id": "ENSXETT00000011460", "name": "MTMR2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324060", "map_id": "none", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806238", "map_id": "CHEBI:16152", "name": "PI(3,4)P2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1806200", "map_id": "CHEBI:17283", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "reaction_10324022", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806199", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_1806180", "map_id": "CHEBI:17526", "name": "PI4P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "reaction_10324050", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "reaction_10334562", "map_id": "none", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10334558", "map_id": "A0A6I8R2K2", "name": "mtmr12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000015585", "map_id": "ENSXETG00000015585", "name": "mtmr12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10334560", "map_id": "none", "name": "MTMR2:MTMR12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F6VED7", "map_id": "F6VED7", "name": "MTMR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R2K2", "map_id": "A0A6I8R2K2", "name": "mtmr12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334573", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5676030", "map_id": "CHEBI:26034", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10334568", "map_id": "none", "name": "MTMR2:SBF1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A6I8Q167", "map_id": "A0A6I8Q167", "name": "sbf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000023079", "map_id": "ENSXETG00000023079", "name": "sbf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334570", "map_id": "none", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10334566", "map_id": "A0A6I8Q167", "name": "sbf1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10324004", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10323989", "map_id": "Q28G26", "name": "pi4k2b", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10334576", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6809774", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_422529", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10324011", "map_id": "none", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1806165", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10324008", "map_id": "A0A6I8QH48", "name": "INPP5E", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000038322", "map_id": "ENSXETG00000038322", "name": "INPP5E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324067", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1524146", "map_id": "CHEBI:16749", "name": "PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10335920", "map_id": "none", "name": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane" }, { "id": "species_8874484", "map_id": "none", "name": "PI(4,5)P2, PI(3,4,5)P3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "species_8874460", "map_id": "none", "name": "PI(4,5)P2, PI(3,4,5)P3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10335917", "map_id": "none", "name": "TNFAIP8 proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8R443", "map_id": "A0A6I8R443", "name": "tnfaip8l3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036250", "map_id": "ENSXETG00000036250", "name": "tnfaip8l3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324040", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_1806289", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "species_1806212", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "reaction_10324001", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_1806198", "map_id": "CHEBI:17283", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "species_1806195", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "reaction_10335862", "map_id": "none", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1602448", "map_id": "CHEBI:16337", "name": "PA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_426755", "map_id": "CHEBI:16337", "name": "PA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10335859", "map_id": "A0A6I8QNC5", "name": "pitpnm3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000020679", "map_id": "ENSXETG00000020679", "name": "pitpnm3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323390", "map_id": "none", "name": "PETA is dephosphorylated to ETA by PHOSPHO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428686", "map_id": "CHEBI:17553", "name": "PETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1498751", "map_id": "CHEBI:16000", "name": "ETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10323387", "map_id": "none", "name": "PHOSPHO1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8PRS6", "map_id": "A0A6I8PRS6", "name": "phospho1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033588", "map_id": "ENSXETG00000033588", "name": "phospho1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323403", "map_id": "none", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10323371", "map_id": "none", "name": "CHKB:CHKB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8PNM3", "map_id": "A0A6I8PNM3", "name": "chkb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031132", "map_id": "ENSXETG00000031132", "name": "chkb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323365", "map_id": "none", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500603", "map_id": "CHEBI:16732", "name": "CDP-ETA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1500596", "map_id": "CHEBI:17815", "name": "DAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1500581", "map_id": "CHEBI:16038", "name": "PE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_109395", "map_id": "CHEBI:17361", "name": "CMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10323362", "map_id": "none", "name": "CEPT1/EPT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q28H54", "map_id": "Q28H54", "name": "cept1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000009560", "map_id": "ENSXETT00000009560", "name": "cept1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QF66", "map_id": "A0A6I8QF66", "name": "EPT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036824", "map_id": "ENSXETG00000036824", "name": "EPT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323400", "map_id": "none", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_264618", "map_id": "CHEBI:15354", "name": "Cho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1500646", "map_id": "CHEBI:18303", "name": "PS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10323397", "map_id": "A0A6I8QLL3", "name": "ptdss1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000036605", "map_id": "ENSXETG00000036605", "name": "ptdss1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323381", "map_id": "none", "name": "PE is converted to PS by PTDSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10323378", "map_id": "A0A6I8RQH9", "name": "ptdss2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000027078", "map_id": "ENSXETG00000027078", "name": "ptdss2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323309", "map_id": "none", "name": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524072", "map_id": "CHEBI:28494", "name": "cardiolipin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524079", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524075", "map_id": "CHEBI:16110", "name": "PC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1498773", "map_id": "CHEBI:60430", "name": "MLCL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10323303", "map_id": "F6X419", "name": "taz", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "ENSXETT00000007327", "map_id": "ENSXETT00000007327", "name": "taz", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323341", "map_id": "none", "name": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524089", "map_id": "CHEBI:29017", "name": "1-acyl LPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524083", "map_id": "CHEBI:16038", "name": "PE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10323290", "map_id": "none", "name": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1498753", "map_id": "CHEBI:60431", "name": "DLCL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524085", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10323287", "map_id": "none", "name": "PLA2G4A:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10323332", "map_id": "none", "name": "DLCL is acylated to MLCL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524080", "map_id": "CHEBI:60431", "name": "DLCL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1524069", "map_id": "CHEBI:60430", "name": "MLCL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10312131", "map_id": "F7A464", "name": "lpgat1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETT00000031524", "map_id": "ENSXETT00000031524", "name": "lpgat1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323328", "map_id": "none", "name": "MLCL is acylated to CL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524081", "map_id": "CHEBI:28494", "name": "CL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10331497", "map_id": "none", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5696449", "map_id": "CHEBI:17408", "name": "MAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_6782195", "map_id": "CHEBI:17984", "name": "Acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10331494", "map_id": "Q6P342", "name": "dgat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10323338", "map_id": "none", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500594", "map_id": "CHEBI:17855", "name": "TAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10334710", "map_id": "none", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10334707", "map_id": "Q6P342", "name": "dgat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10323276", "map_id": "none", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498722", "map_id": "CHEBI:37646", "name": "2-acyl LPS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10312127", "map_id": "Q28C60", "name": "lpcat4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETT00000037017", "map_id": "ENSXETT00000037017", "name": "lpcat4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323343", "map_id": "none", "name": "PS is hydrolyzed to 2-acyl LPS by PLA2[10]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524021", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10323253", "map_id": "none", "name": "PLA2G4A:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10323299", "map_id": "none", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[9]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498724", "map_id": "CHEBI:52603", "name": "1-acyl LPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10323296", "map_id": "none", "name": "PLA2(9)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8PMU8", "map_id": "A0A6I8PMU8", "name": "plaat4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000029956", "map_id": "ENSXETG00000029956", "name": "plaat4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323266", "map_id": "none", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10323810", "map_id": "none", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602419", "map_id": "CHEBI:52603", "name": "1-acyl LPS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1602366", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10323805", "map_id": "none", "name": "PLA2(16)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q28GM9", "map_id": "Q28GM9", "name": "pla2g12a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000083864", "map_id": "ENSXETT00000083864", "name": "pla2g12a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6TK24", "map_id": "F6TK24", "name": "PLA2G10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000024072", "map_id": "ENSXETT00000024072", "name": "PLA2G10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336015", "map_id": "none", "name": "ACP6 hydrolyses MYS-LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8878649", "map_id": "CHEBI:62833", "name": "MYS-LPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8934414", "map_id": "CHEBI:75562", "name": "1-MMG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10336012", "map_id": "F7EEN4", "name": "LOC100498221", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "ENSXETT00000009623", "map_id": "ENSXETT00000009623", "name": "LOC100498221", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312153", "map_id": "none", "name": "DHAP is converted to G3P by GPD1/GPD1L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76114", "map_id": "CHEBI:15978", "name": "G3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312150", "map_id": "none", "name": "GPD1/GPD1L homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F6XXP1", "map_id": "F6XXP1", "name": "mtfr2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000038446", "map_id": "ENSXETT00000038446", "name": "mtfr2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6P824", "map_id": "Q6P824", "name": "gpd1l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000032859", "map_id": "ENSXETT00000032859", "name": "gpd1l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312136", "map_id": "none", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500604", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312133", "map_id": "none", "name": "AGPAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q28C60", "map_id": "Q28C60", "name": "lpcat4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7A464", "map_id": "F7A464", "name": "lpgat1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323256", "map_id": "none", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_1500590", "map_id": "CHEBI:16337", "name": "PA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_1500580", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_1524103", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10336024", "map_id": "none", "name": "ALPI dimer hydrolyses phosphate monoesters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8878780", "map_id": "CHEBI:7794", "name": "phosphate monoester", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8878776", "map_id": "CHEBI:30879", "name": "Alcohol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10336021", "map_id": "none", "name": "ALPI:2Ca2+:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8RU07", "map_id": "A0A6I8RU07", "name": "alpi.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000032063", "map_id": "ENSXETG00000032063", "name": "alpi.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10332427", "map_id": "none", "name": "LIPH, I hydrolyse PA to 2-acyl LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_6792472", "map_id": "CHEBI:17936", "name": "2-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10332424", "map_id": "none", "name": "LIPH, I", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q5XGE9", "map_id": "Q5XGE9", "name": "liph", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000005849", "map_id": "ENSXETG00000005849", "name": "liph", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6XB15", "map_id": "F6XB15", "name": "lipg", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000048464", "map_id": "ENSXETT00000048464", "name": "lipg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "L7N2H3", "map_id": "L7N2H3", "name": "LOC100487482", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000002050", "map_id": "ENSXETT00000002050", "name": "LOC100487482", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336954", "map_id": "none", "name": "PLD6 dimer hydrolyses cardiolipin to PA and PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_189422", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_8954419", "map_id": "CHEBI:28494", "name": "cardiolipin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_8954401", "map_id": "CHEBI:17517", "name": "PG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10336945", "map_id": "none", "name": "PLD6 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q28DT3", "map_id": "Q28DT3", "name": "pld6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000005747", "map_id": "ENSXETG00000005747", "name": "pld6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10336952", "map_id": "none", "name": "MIGA2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "A0A6I8QVP8", "map_id": "A0A6I8QVP8", "name": "miga2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000018962", "map_id": "ENSXETG00000018962", "name": "miga2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323818", "map_id": "none", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602447", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10323270", "map_id": "none", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10323283", "map_id": "none", "name": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10323280", "map_id": "A0A6I8QDV9", "name": "gpat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "ENSXETG00000033567", "map_id": "ENSXETG00000033567", "name": "gpat2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10332322", "map_id": "none", "name": "DDHD1,2 hydrolyse PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10332319", "map_id": "none", "name": "DDHD1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SK52", "map_id": "A0A6I8SK52", "name": "ddhd2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000015184", "map_id": "ENSXETG00000015184", "name": "ddhd2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QC54", "map_id": "A0A6I8QC54", "name": "ddhd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038294", "map_id": "ENSXETG00000038294", "name": "ddhd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323321", "map_id": "none", "name": "PE is hydrolyzed to 2-acyl LPE by PLA2[4]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498729", "map_id": "CHEBI:28936", "name": "2-acyl LPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10323336", "map_id": "none", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498738", "map_id": "CHEBI:29017", "name": "1-acyl LPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10323313", "map_id": "A0A6I8S9K5", "name": "pnpla8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000015758", "map_id": "ENSXETG00000015758", "name": "pnpla8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323272", "map_id": "none", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10335402", "map_id": "none", "name": "HRASLS transfer acyl group from PC to PE to form NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5694568", "map_id": "CHEBI:61232", "name": "NAPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_6814253", "map_id": "CHEBI:58168", "name": "LysoPtdCho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10335399", "map_id": "none", "name": "HRASLS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SG35", "map_id": "A0A6I8SG35", "name": "HRASLS2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035934", "map_id": "ENSXETG00000035934", "name": "HRASLS2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RYC6", "map_id": "A0A6I8RYC6", "name": "plaat3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038318", "map_id": "ENSXETG00000038318", "name": "plaat3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q9S3", "map_id": "A0A6I8Q9S3", "name": "HRASLS2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323268", "map_id": "none", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10323334", "map_id": "none", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10323814", "map_id": "none", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602375", "map_id": "CHEBI:16038", "name": "PE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1602372", "map_id": "CHEBI:29017", "name": "1-acyl LPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10323262", "map_id": "none", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498737", "map_id": "CHEBI:62746", "name": "2-acyl LPI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10323248", "map_id": "A0A6I8SZ57", "name": "mboat7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000036938", "map_id": "ENSXETG00000036938", "name": "mboat7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323812", "map_id": "none", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602420", "map_id": "CHEBI:28914", "name": "1-acyl LPI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10323318", "map_id": "none", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[11]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498733", "map_id": "CHEBI:28914", "name": "1-acyl LPI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10323251", "map_id": "none", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10323259", "map_id": "none", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_975614", "map_id": "CHEBI:16728", "name": "2-acyl LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1498750", "map_id": "CHEBI:16870", "name": "GPCho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10323274", "map_id": "none", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524028", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10323374", "map_id": "none", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1524071", "map_id": "CHEBI:36700", "name": "PCho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10318360", "map_id": "none", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10318357", "map_id": "B0JZD0", "name": "slc44a5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000002987", "map_id": "ENSXETG00000002987", "name": "slc44a5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323354", "map_id": "none", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524060", "map_id": "CHEBI:16436", "name": "CDP-Cho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10323351", "map_id": "none", "name": "CEPT1:Mg2+/Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10323393", "map_id": "none", "name": "PCho is dephosphorylated to Cho by PHOSPHO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10335730", "map_id": "none", "name": "MFSD2A transports LPC from extracellular region to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8865642", "map_id": "CHEBI:64567", "name": "LPC (22:6)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8865629", "map_id": "CHEBI:64567", "name": "LPC (22:6)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10335727", "map_id": "Q0IHM1", "name": "mfsd2a", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000002564", "map_id": "ENSXETT00000002564", "name": "mfsd2a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323325", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10323244", "map_id": "none", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10323816", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_429802", "map_id": "CHEBI:16110", "name": "PC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1602390", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10323316", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10323239", "map_id": "none", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10323330", "map_id": "none", "name": "PC is hydrolysed to 2-acyl LPC by PLA2[7]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10323242", "map_id": "none", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498740", "map_id": "CHEBI:62747", "name": "1-acyl LPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1483256", "map_id": "CHEBI:17517", "name": "PG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10323345", "map_id": "none", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10323264", "map_id": "none", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498730", "map_id": "CHEBI:27923", "name": "2-acyl LPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10323808", "map_id": "none", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602402", "map_id": "CHEBI:17517", "name": "PG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1602415", "map_id": "CHEBI:62747", "name": "1-acyl LPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10311977", "map_id": "none", "name": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_73871", "map_id": "CHEBI:15345", "name": "ACA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10311959", "map_id": "none", "name": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_73911", "map_id": "CHEBI:17066", "name": "bHBA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_73909", "map_id": "CHEBI:15344", "name": "ACA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10311952", "map_id": "none", "name": "BDH1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "F6RPR3", "map_id": "F6RPR3", "name": "LOC100497276", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000007485", "map_id": "ENSXETT00000007485", "name": "LOC100497276", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10331407", "map_id": "none", "name": "AACS ligates CoA-SH to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29666", "map_id": "CHEBI:13705", "name": "ACA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191293", "map_id": "CHEBI:15345", "name": "ACA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10331404", "map_id": "Q28BL6", "name": "aacs", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000001210", "map_id": "ENSXETG00000001210", "name": "aacs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335941", "map_id": "none", "name": "ACSS3 ligates CoA to CH3COO-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10335938", "map_id": "A0A6I8Q3I8", "name": "acss3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "ENSXETG00000014528", "map_id": "ENSXETG00000014528", "name": "acss3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10332359", "map_id": "none", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10332356", "map_id": "none", "name": "HMGCLL1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8PVX1", "map_id": "A0A6I8PVX1", "name": "hmgcll1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000007070", "map_id": "ENSXETG00000007070", "name": "hmgcll1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311955", "map_id": "none", "name": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10331506", "map_id": "none", "name": "BDH2 dehydrogenates 3HBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5696461", "map_id": "CHEBI:10983", "name": "3HBA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10331503", "map_id": "none", "name": "BDH2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8RES0", "map_id": "A0A6I8RES0", "name": "bdh2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000021320", "map_id": "ENSXETG00000021320", "name": "bdh2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337487", "map_id": "none", "name": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024765", "map_id": "CHEBI:138642", "name": "7(S)-Hp-17(S)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024768", "map_id": "CHEBI:138646", "name": "7S(8)-epoxy-17(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10318105", "map_id": "A0A6I8R1G6", "name": "alox5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000007490", "map_id": "ENSXETG00000007490", "name": "alox5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337499", "map_id": "none", "name": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024815", "map_id": "CHEBI:138640", "name": "17(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337493", "map_id": "none", "name": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024797", "map_id": "CHEBI:138641", "name": "4(S)-Hp-17(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337495", "map_id": "none", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024781", "map_id": "CHEBI:138647", "name": "4S(5)-epoxy-17(S)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337485", "map_id": "none", "name": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024463", "map_id": "CHEBI:91137", "name": "17(R)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024479", "map_id": "CHEBI:138602", "name": "7(S)-Hp-17(R)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337497", "map_id": "none", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024576", "map_id": "CHEBI:138601", "name": "4(S)-Hp-17(R)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024577", "map_id": "CHEBI:138612", "name": "4S(5)-epoxy-17(R)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337489", "map_id": "none", "name": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024602", "map_id": "CHEBI:138613", "name": "7S(8)-epoxy-17(R)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337491", "map_id": "none", "name": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10337534", "map_id": "none", "name": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9025012", "map_id": "CHEBI:140220", "name": "14(S)-Hp-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024989", "map_id": "CHEBI:140196", "name": "7(S),14(S)-diHp-DHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337565", "map_id": "none", "name": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9027049", "map_id": "CHEBI:137346", "name": "14(R)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9027324", "map_id": "none", "name": "14(R),21(S/R)-diHDHA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:137368", "map_id": "CHEBI:137368", "name": "CHEBI:137368", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:137361", "map_id": "CHEBI:137361", "name": "CHEBI:137361", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312165", "map_id": "A0A6I8PUP3", "name": "cyp2c8.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10337560", "map_id": "none", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024011", "map_id": "CHEBI:28125", "name": "DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10337557", "map_id": "none", "name": "CYP1A2,2C8,2C9,2D6,2E1,3A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10337563", "map_id": "none", "name": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9027029", "map_id": "CHEBI:137347", "name": "14(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9027326", "map_id": "none", "name": "14(S),21(S/R)-diHDHA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:137360", "map_id": "CHEBI:137360", "name": "CHEBI:137360", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:137354", "map_id": "CHEBI:137354", "name": "CHEBI:137354", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337696", "map_id": "none", "name": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_9024886", "map_id": "CHEBI:138655", "name": "(N)PD1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9037755", "map_id": "CHEBI:140243", "name": "22-OH-(N)PD1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337555", "map_id": "none", "name": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9026915", "map_id": "CHEBI:140268", "name": "RCTR1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10337550", "map_id": "none", "name": "LTC4S trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A6I8QSM3", "map_id": "A0A6I8QSM3", "name": "LTC4S", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036146", "map_id": "ENSXETG00000036146", "name": "LTC4S", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337553", "map_id": "none", "name": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9025001", "map_id": "CHEBI:132228", "name": "13(S),14(S)-epoxy-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9026761", "map_id": "CHEBI:138202", "name": "MCTR1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337567", "map_id": "none", "name": "ALOX5 oxidises DHA to 7-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9028274", "map_id": "CHEBI:72623", "name": "7-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337569", "map_id": "none", "name": "ALOX5 oxidises EPA to 5-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2026977", "map_id": "CHEBI:28364", "name": "EPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9028283", "map_id": "CHEBI:72801", "name": "5-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337571", "map_id": "none", "name": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9608444", "map_id": "CHEBI:53488", "name": "DPAn-3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9028240", "map_id": "CHEBI:140250", "name": "7-HDPAn-3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337542", "map_id": "none", "name": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9026293", "map_id": "CHEBI:140222", "name": "14(S)-Hp-DPAn-3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9026311", "map_id": "CHEBI:140258", "name": "MaR3n-3 DPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337544", "map_id": "none", "name": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9026400", "map_id": "CHEBI:91274", "name": "13(R)-HDPAn-3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9026394", "map_id": "none", "name": "RvT1-4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:137020", "map_id": "CHEBI:137020", "name": "CHEBI:137020", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:137011", "map_id": "CHEBI:137011", "name": "CHEBI:137011", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:137018", "map_id": "CHEBI:137018", "name": "CHEBI:137018", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:137019", "map_id": "CHEBI:137019", "name": "CHEBI:137019", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337540", "map_id": "none", "name": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9026047", "map_id": "CHEBI:140226", "name": "17(S)-Hp-DPAn-3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9026046", "map_id": "CHEBI:140224", "name": "16(S),17(S)-epoxy-DPAn-3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337536", "map_id": "none", "name": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9026034", "map_id": "CHEBI:140248", "name": "7,17-diHp-DPAn-3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9026050", "map_id": "CHEBI:140234", "name": "7,8-epoxy,17-HDPAn-3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337538", "map_id": "none", "name": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10337481", "map_id": "none", "name": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9023651", "map_id": "CHEBI:81563", "name": "18(R)-HEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9023702", "map_id": "CHEBI:132908", "name": "5(S)-Hp-18(R)-HEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337483", "map_id": "none", "name": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9023708", "map_id": "CHEBI:138563", "name": "5S,6S-epoxy-18(R)-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337477", "map_id": "none", "name": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9020474", "map_id": "CHEBI:132801", "name": "18(S)-HEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9020602", "map_id": "CHEBI:132802", "name": "5(S)-Hp-18(S)-HEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337479", "map_id": "none", "name": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9022655", "map_id": "CHEBI:138490", "name": "5S,6S-epoxy-18(S)-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10312123", "map_id": "none", "name": "DHRS7B reduces GO3P to HXDG3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_75973", "map_id": "CHEBI:17197", "name": "GO3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_390422", "map_id": "CHEBI:63818", "name": "HXDG3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312120", "map_id": "Q0VFE7", "name": "dhrs7b", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "ENSXETT00000013330", "map_id": "ENSXETT00000013330", "name": "dhrs7b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334716", "map_id": "none", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10334713", "map_id": "none", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8848577", "map_id": "CHEBI:16125", "name": "HXOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8848499", "map_id": "CHEBI:75584", "name": "PALM-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10326149", "map_id": "none", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161185", "map_id": "none", "name": "abacavir", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2162081", "map_id": "CHEBI:64192", "name": "abacavir 5'-carboxylic acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311790", "map_id": "none", "name": "ADH1A:2Zn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10326146", "map_id": "none", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161514", "map_id": "none", "name": "carbovir", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2161176", "map_id": "none", "name": "carbovir monophosphate", "type": "product", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10324293", "map_id": "none", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10324290", "map_id": "none", "name": "PLCdegh", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8QLK5", "map_id": "A0A6I8QLK5", "name": "plce1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000030514", "map_id": "ENSXETG00000030514", "name": "plce1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SLR0", "map_id": "A0A6I8SLR0", "name": "plcg2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000003578", "map_id": "ENSXETG00000003578", "name": "plcg2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QCS0", "map_id": "A0A6I8QCS0", "name": "plch1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000007772", "map_id": "ENSXETG00000007772", "name": "plch1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324274", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_994170", "map_id": "CHEBI:16783", "name": "I(1,3,4,5)P4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_994123", "map_id": "CHEBI:18228", "name": "I(1,3,4)P3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10324265", "map_id": "none", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629746", "map_id": "CHEBI:28858", "name": "I(3,4)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629731", "map_id": "CHEBI:18169", "name": "I3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10324246", "map_id": "none", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629769", "map_id": "CHEBI:18225", "name": "I(1,3)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10324243", "map_id": "none", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629739", "map_id": "CHEBI:17816", "name": "I(1,4)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10324268", "map_id": "none", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023929", "map_id": "CHEBI:17401", "name": "IP6", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2023940", "map_id": "CHEBI:30164", "name": "5-PP-IP5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10324230", "map_id": "F7D664", "name": "ip6k2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10324249", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023901", "map_id": "CHEBI:16322", "name": "I(1,3,4,5,6)P5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2023922", "map_id": "CHEBI:62928", "name": "5-PP-IP4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10324233", "map_id": "none", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023932", "map_id": "CHEBI:62919", "name": "1-PP-IP5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2023931", "map_id": "CHEBI:62923", "name": "1,5-(PP)2-IP4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10324299", "map_id": "none", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023941", "map_id": "CHEBI:62985", "name": "5-PPP-IP5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10324305", "map_id": "none", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023948", "map_id": "CHEBI:62931", "name": "1,5-(PP)2-IP3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10323209", "map_id": "none", "name": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1237009", "map_id": "CHEBI:16526", "name": "CO2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10322211", "map_id": "none", "name": "CA4:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8QID1", "map_id": "A0A6I8QID1", "name": "ca4.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034545", "map_id": "ENSXETG00000034545", "name": "ca4.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323220", "map_id": "none", "name": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10323222", "map_id": "none", "name": "Carbonic anhydrase hydrates carbon dioxide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10323215", "map_id": "none", "name": "CA7:Zinc", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q28CD7", "map_id": "Q28CD7", "name": "ca7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000069496", "map_id": "ENSXETT00000069496", "name": "ca7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323218", "map_id": "none", "name": "Carbonic anhydrase dehydrates bicarbonate (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10331322", "map_id": "none", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_5693930", "map_id": "CHEBI:18915", "name": "Gal1,3GlcNAc group", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_5693933", "map_id": "CHEBI:18914", "name": "Gal1,3Fuc1,4GlcNAc group", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10321826", "map_id": "none", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_975910", "map_id": "CHEBI:59520", "name": "NGP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_1028779", "map_id": "none", "name": "NGP:1,6-GlcNAc", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10321823", "map_id": "Q6NVP8", "name": "fut8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETT00000016641", "map_id": "ENSXETT00000016641", "name": "fut8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318217", "map_id": "none", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen" }, { "id": "species_216785", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "species_10318214", "map_id": "Q28CE7", "name": "slc30a5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "false" }, { "id": "ENSXETG00000000472", "map_id": "ENSXETG00000000472", "name": "slc30a5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318231", "map_id": "none", "name": "ZnT6 transports zinc into the golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_216667", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10318228", "map_id": "Q5I0B2", "name": "slc30a6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETT00000054089", "map_id": "ENSXETT00000054089", "name": "slc30a6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318224", "map_id": "none", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10318221", "map_id": "Q5XHB4", "name": "slc30a8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "false" }, { "id": "ENSXETG00000027945", "map_id": "ENSXETG00000027945", "name": "slc30a8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318210", "map_id": "none", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_158417", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10318207", "map_id": "A0A6I8SQD1", "name": "LOC101730999", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000034450", "map_id": "ENSXETG00000034450", "name": "LOC101730999", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336888", "map_id": "none", "name": "SLC38A9 binds Ragulator:Rag dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10330239", "map_id": "A0A6I8RIW4", "name": "slc38a9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "ENSXETG00000028090", "map_id": "ENSXETG00000028090", "name": "slc38a9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330253", "map_id": "none", "name": "Ragulator:RagA,B:GTP:RagC,D:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "F6W400", "map_id": "F6W400", "name": "RRAGB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000041436", "map_id": "ENSXETT00000041436", "name": "RRAGB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B4F6Y3", "map_id": "B4F6Y3", "name": "lamtor3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000026765", "map_id": "ENSXETG00000026765", "name": "lamtor3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6DF40", "map_id": "Q6DF40", "name": "lamtor2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000020403", "map_id": "ENSXETG00000020403", "name": "lamtor2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A9UL91", "map_id": "A9UL91", "name": "lamtor5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000103950", "map_id": "ENSXETT00000103950", "name": "lamtor5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6P2W7", "map_id": "Q6P2W7", "name": "lamtor1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000024963", "map_id": "ENSXETG00000024963", "name": "lamtor1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330255", "map_id": "none", "name": "Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "A0A6I8RIW4", "map_id": "A0A6I8RIW4", "name": "slc38a9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336891", "map_id": "none", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428011", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10338102", "map_id": "none", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10338098", "map_id": "F7BKJ1", "name": "FKBP1A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000003463", "map_id": "ENSXETT00000003463", "name": "FKBP1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9678687", "map_id": "none", "name": "sirolimus", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10338100", "map_id": "none", "name": "FKBP1A:sirolimus", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F7BKJ1", "map_id": "F7BKJ1", "name": "FKBP1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10338253", "map_id": "none", "name": "FeHM oxidises LDL,HDL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10338243", "map_id": "none", "name": "LDL,HDL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_917877", "map_id": "CHEBI:17627", "name": "heme", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10338251", "map_id": "none", "name": "oxidized LDL,HDL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10338255", "map_id": "none", "name": "BACH1 binds MAFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10321780", "map_id": "F7A9R6", "name": "MAFK", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000041786", "map_id": "ENSXETT00000041786", "name": "MAFK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10338235", "map_id": "F6Y302", "name": "BACH1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000017505", "map_id": "ENSXETT00000017505", "name": "BACH1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10338237", "map_id": "none", "name": "BACH1:MAFK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "F6Y302", "map_id": "F6Y302", "name": "BACH1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7A9R6", "map_id": "F7A9R6", "name": "MAFK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10338231", "map_id": "none", "name": "FeHM dissociates from MetHb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10326232", "map_id": "none", "name": "MetHb", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "P07428", "map_id": "P07428", "name": "hba-A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000002494", "map_id": "ENSXETT00000002494", "name": "hba-A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P07429", "map_id": "P07429", "name": "hbb1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000054566", "map_id": "ENSXETT00000054566", "name": "hbb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P08423", "map_id": "P08423", "name": "hbb2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000024627", "map_id": "ENSXETG00000024627", "name": "hbb2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10338229", "map_id": "none", "name": "ApoHb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10338241", "map_id": "none", "name": "Hemes bind to BACH1:MAFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_9707575", "map_id": "none", "name": "Hemes", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10338239", "map_id": "none", "name": "BACH1:Hemes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10338226", "map_id": "none", "name": "H2O2 oxidises ferrohemoglobin to MetHb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10338222", "map_id": "none", "name": "ferrohemoglobin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_9707624", "map_id": "CHEBI:29191", "name": "hydroxyl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_9707647", "map_id": "CHEBI:16234", "name": "hydroxide", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10338224", "map_id": "none", "name": "COHb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_9709335", "map_id": "CHEBI:17245", "name": "CO", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10327581", "map_id": "none", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1222424", "map_id": "CHEBI:18421", "name": "O2.-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10327578", "map_id": "none", "name": "2xHC-SOD1:Zn2+:Cu2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_209799", "map_id": "CHEBI:29036", "name": "Cu2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "Q0IIW3", "map_id": "Q0IIW3", "name": "sod1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000015994", "map_id": "ENSXETT00000015994", "name": "sod1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10331455", "map_id": "none", "name": "NUDT2 hydrolyses GP4G to GTP, GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5696199", "map_id": "CHEBI:15883", "name": "GP4G", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10331452", "map_id": "F6Q6H7", "name": "nudt2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "ENSXETT00000004614", "map_id": "ENSXETT00000004614", "name": "nudt2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327705", "map_id": "none", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_3341308", "map_id": "CHEBI:18421", "name": "O2-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10313148", "map_id": "none", "name": "Cytochrome c (oxidised)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "CHEBI:38574", "map_id": "CHEBI:38574", "name": "CHEBI:38574", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_189461", "map_id": "CHEBI:15379", "name": "O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10313146", "map_id": "none", "name": "Cytochrome c (reduced)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "CHEBI:38573", "map_id": "CHEBI:38573", "name": "CHEBI:38573", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328075", "map_id": "none", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10327691", "map_id": "Q641J6", "name": "txn2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "ENSXETT00000089705", "map_id": "ENSXETT00000089705", "name": "txn2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_3697881", "map_id": "CHEBI:25941", "name": "Peroxynitrite", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_3697842", "map_id": "CHEBI:16301", "name": "Nitrite", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10327694", "map_id": "Q641J6", "name": "txn2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10327698", "map_id": "F7ESR7", "name": "prdx5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "ENSXETT00000013225", "map_id": "ENSXETT00000013225", "name": "prdx5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328149", "map_id": "none", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_189481", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10328146", "map_id": "none", "name": "SOD1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "reaction_10327701", "map_id": "none", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_1614617", "map_id": "CHEBI:16240", "name": "H2O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10327715", "map_id": "none", "name": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_3341331", "map_id": "CHEBI:17858", "name": "GSSG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10327712", "map_id": "none", "name": "GPX3 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q6P8G5", "map_id": "Q6P8G5", "name": "gpx3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000098364", "map_id": "ENSXETT00000098364", "name": "gpx3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10333618", "map_id": "none", "name": "GPX5,6 reduce H2O2 to H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10333613", "map_id": "Q6P8G5", "name": "gpx3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10338265", "map_id": "none", "name": "CO binds to free ferrohemoglobin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10338267", "map_id": "none", "name": "H2O2 reduces MetHb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10338261", "map_id": "none", "name": "BACH1 translocates from the nucleoplasm to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10338259", "map_id": "F6Y302", "name": "BACH1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_3785707", "map_id": "CHEBI:26523", "name": "ROS", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10321885", "map_id": "none", "name": "HIF-alpha translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10321881", "map_id": "A0A6I8Q6W5", "name": "epas1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000026167", "map_id": "ENSXETG00000026167", "name": "epas1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10321883", "map_id": "A0A6I8Q6W5", "name": "epas1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10328289", "map_id": "none", "name": "CEBPB homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328281", "map_id": "Q3SYP1", "name": "phospho-cebpb", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000085676", "map_id": "ENSXETT00000085676", "name": "phospho-cebpb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328283", "map_id": "none", "name": "p-T235,S321-CEBPB homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q3SYP1", "map_id": "Q3SYP1", "name": "phospho-cebpb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327348", "map_id": "none", "name": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10327345", "map_id": "none", "name": "CDKN2A Gene:Nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8QNX3", "map_id": "A0A6I8QNX3", "name": "HIST1H3A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039206", "map_id": "ENSXETG00000039206", "name": "HIST1H3A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SS59", "map_id": "A0A6I8SS59", "name": "HIST2H3A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039803", "map_id": "ENSXETG00000039803", "name": "HIST2H3A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10327343", "map_id": "none", "name": "CDKN2A Gene:H3K27Me3-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10316473", "map_id": "none", "name": "PRC2 (EZH2) Core", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q28DT7", "map_id": "Q28DT7", "name": "eed", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000022912", "map_id": "ENSXETT00000022912", "name": "eed", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6P315", "map_id": "Q6P315", "name": "rbbp7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000002157", "map_id": "ENSXETT00000002157", "name": "rbbp7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28D84", "map_id": "Q28D84", "name": "ezh2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000020146", "map_id": "ENSXETG00000020146", "name": "ezh2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327310", "map_id": "none", "name": "Phosphorylated ERF translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10327306", "map_id": "A0A6I8PZK0", "name": "phospho-erf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000012067", "map_id": "ENSXETG00000012067", "name": "phospho-erf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10327308", "map_id": "A0A6I8PZK0", "name": "phospho-erf", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10312580", "map_id": "none", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_30389", "map_id": "CHEBI:17489", "name": "cAMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10312577", "map_id": "none", "name": "Adenylate cyclase (Mg2+ cofactor)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "L7N333", "map_id": "L7N333", "name": "ADCY1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000019255", "map_id": "ENSXETT00000019255", "name": "ADCY1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6WUY6", "map_id": "F6WUY6", "name": "ADCY9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000027105", "map_id": "ENSXETT00000027105", "name": "ADCY9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312589", "map_id": "none", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312586", "map_id": "none", "name": "activated PDE1C dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F6YP15", "map_id": "F6YP15", "name": "LOC100497503", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000040456", "map_id": "ENSXETT00000040456", "name": "LOC100497503", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312591", "map_id": "none", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10335005", "map_id": "none", "name": "GALNT3 transfers GalNAc to FGF23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10335000", "map_id": "A0A6I8PM12", "name": "fgf23.2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "ENSXETG00000026353", "map_id": "ENSXETG00000026353", "name": "fgf23.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335002", "map_id": "A0A6I8PM12", "name": "fgf23.2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10320310", "map_id": "F6VQB1", "name": "galnt3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10335007", "map_id": "none", "name": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10314114", "map_id": "A0A6I8PM12", "name": "fgf23.2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10320127", "map_id": "none", "name": "P2X7 mediates loss of intracellular K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10320124", "map_id": "none", "name": "ATP:P2X7 oligomer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8S619", "map_id": "A0A6I8S619", "name": "LOC100490828", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000041261", "map_id": "ENSXETG00000041261", "name": "LOC100490828", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10320159", "map_id": "none", "name": "PSTPIP1 binds Pyrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10320155", "map_id": "none", "name": "PSTPIP1 trimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8QK31", "map_id": "A0A6I8QK31", "name": "pstpip1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033202", "map_id": "ENSXETG00000033202", "name": "pstpip1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320139", "map_id": "none", "name": "Pyrin trimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "K9J7V3", "map_id": "K9J7V3", "name": "TRIM39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000014255", "map_id": "ENSXETT00000014255", "name": "TRIM39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7CTL7", "map_id": "F7CTL7", "name": "LOC100495443", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000018292", "map_id": "ENSXETT00000018292", "name": "LOC100495443", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320157", "map_id": "none", "name": "PSTPIP1 trimer:Pyrin trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10320120", "map_id": "none", "name": "NLRP1 senses MDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_708341", "map_id": "CHEBI:59414", "name": "MDP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10320110", "map_id": "none", "name": "Homologues of NLRP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8QL30", "map_id": "A0A6I8QL30", "name": "NLRP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038851", "map_id": "ENSXETG00000038851", "name": "NLRP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q7C5", "map_id": "A0A6I8Q7C5", "name": "NLRP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PU00", "map_id": "A0A6I8PU00", "name": "LOC108644487", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038253", "map_id": "ENSXETG00000038253", "name": "LOC108644487", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320112", "map_id": "none", "name": "MDP:NLRP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10320149", "map_id": "none", "name": "Bcl-2 and Bcl-XL bind NLRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10320145", "map_id": "none", "name": "Bcl-2/Bcl-X(L)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "A0A6I8QYM7", "map_id": "A0A6I8QYM7", "name": "bcl2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035771", "map_id": "ENSXETG00000035771", "name": "bcl2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6XC18", "map_id": "F6XC18", "name": "BCL2L1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000050759", "map_id": "ENSXETT00000050759", "name": "BCL2L1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320147", "map_id": "none", "name": "Bcl-2/Bcl-X(L):NLRP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10320118", "map_id": "none", "name": "NLRP1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10320114", "map_id": "none", "name": "MDP:NLRP1:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10320116", "map_id": "none", "name": "MDP:NLRP1:ATP oligomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10320161", "map_id": "none", "name": "MDP:NLRP1 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10320168", "map_id": "none", "name": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_879559", "map_id": "none", "name": "LCFAs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_879544", "map_id": "none", "name": "LCFAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10320165", "map_id": "A0A6I8S4U3", "name": "slc27a4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000037018", "map_id": "ENSXETG00000037018", "name": "slc27a4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10322403", "map_id": "none", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10322400", "map_id": "none", "name": "TWIK2 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F7AEN8", "map_id": "F7AEN8", "name": "kcnk18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000009094", "map_id": "ENSXETT00000009094", "name": "kcnk18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10322456", "map_id": "none", "name": "GHBP binds GHR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10320900", "map_id": "A0A6I8PXI3", "name": "ghr", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000037965", "map_id": "ENSXETG00000037965", "name": "ghr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320910", "map_id": "A0A6I8PXI3", "name": "ghr", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10320912", "map_id": "none", "name": "GHBP:GHR", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PXI3", "map_id": "A0A6I8PXI3", "name": "ghr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10320917", "map_id": "none", "name": "Growth hormone receptor binds JAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10320904", "map_id": "A0A6I8QZL9", "name": "jak2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000000586", "map_id": "ENSXETG00000000586", "name": "jak2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320906", "map_id": "none", "name": "Growth Hormone Receptor:JAK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8QZL9", "map_id": "A0A6I8QZL9", "name": "jak2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10320914", "map_id": "none", "name": "Growth hormone receptor dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10320908", "map_id": "none", "name": "Growth Hormone Receptor-JAK2 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10330559", "map_id": "none", "name": "2xRANK binds RANKL,sRANKL trimer:RANK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10330551", "map_id": "F7DPT4", "name": "tnfrsf11a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000001109", "map_id": "ENSXETT00000001109", "name": "tnfrsf11a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330553", "map_id": "none", "name": "RANK:RANKL,sRANKL trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F7DPT4", "map_id": "F7DPT4", "name": "tnfrsf11a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330557", "map_id": "none", "name": "3xRANK:RANKL,sRANKL trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10330555", "map_id": "none", "name": "RANKL,sRANKL trimer binds RANK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10330455", "map_id": "none", "name": "RANKL,sRANKL trimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10330429", "map_id": "none", "name": "EDA binds EDAR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10330421", "map_id": "A0A6I8RPF6", "name": "eda", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000039649", "map_id": "ENSXETG00000039649", "name": "eda", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330425", "map_id": "Q6DF68", "name": "edar", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000004819", "map_id": "ENSXETT00000004819", "name": "edar", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330427", "map_id": "none", "name": "EDA:EDAR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q6DF68", "map_id": "Q6DF68", "name": "edar", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RPF6", "map_id": "A0A6I8RPF6", "name": "eda", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10330437", "map_id": "none", "name": "EDA-3 binds EDA2R", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10330433", "map_id": "F7D7R4", "name": "eda2r", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000025196", "map_id": "ENSXETT00000025196", "name": "eda2r", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330435", "map_id": "none", "name": "EDA-3:EDA2R", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F7D7R4", "map_id": "F7D7R4", "name": "eda2r", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10330465", "map_id": "none", "name": "LTA trimer binds TNFRSF1A,1B,14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10330459", "map_id": "none", "name": "LTA trimer", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10330461", "map_id": "none", "name": "TNFRSF1A,1B,14", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PXQ3", "map_id": "A0A6I8PXQ3", "name": "tnfrsf14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035588", "map_id": "ENSXETG00000035588", "name": "tnfrsf14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PW21", "map_id": "A0A6I8PW21", "name": "tnfrsf1a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000032118", "map_id": "ENSXETG00000032118", "name": "tnfrsf1a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330463", "map_id": "none", "name": "LTA trimer:TNFRSF1A,1B,14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10332225", "map_id": "none", "name": "CRLF1 binds CLCF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10331527", "map_id": "none", "name": "Homologues of CLCF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "F6UWV2", "map_id": "F6UWV2", "name": "clcf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000045077", "map_id": "ENSXETT00000045077", "name": "clcf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SGV0", "map_id": "A0A6I8SGV0", "name": "CLCF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036989", "map_id": "ENSXETG00000036989", "name": "CLCF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10331531", "map_id": "A0A6I8PWA6", "name": "crlf1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000023198", "map_id": "ENSXETG00000023198", "name": "crlf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10331533", "map_id": "none", "name": "CRLF1:CLCF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8PWA6", "map_id": "A0A6I8PWA6", "name": "crlf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337128", "map_id": "none", "name": "TBK1 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10320676", "map_id": "A0A6I8SCC5", "name": "tbk1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000007322", "map_id": "ENSXETG00000007322", "name": "phospho-tbk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337126", "map_id": "A0A6I8SCC5", "name": "phospho-tbk1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10327030", "map_id": "none", "name": "NFKB1:RELA translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10332406", "map_id": "none", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10332404", "map_id": "A0A6I8T1M9", "name": "hsp90b1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "ENSXETG00000005359", "map_id": "ENSXETG00000005359", "name": "hsp90b1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10332274", "map_id": "none", "name": "IL4R binds JAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10332270", "map_id": "A0A6I8S2C9", "name": "il4r", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000040733", "map_id": "ENSXETG00000040733", "name": "il4r", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10332272", "map_id": "none", "name": "IL4R:JAK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8S2C9", "map_id": "A0A6I8S2C9", "name": "il4r", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318525", "map_id": "none", "name": "IL34 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10318521", "map_id": "A0A6I8QP85", "name": "il34", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000038235", "map_id": "ENSXETG00000038235", "name": "il34", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318523", "map_id": "none", "name": "IL34 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8QP85", "map_id": "A0A6I8QP85", "name": "il34", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318556", "map_id": "none", "name": "CD4 binds Interleukin-16", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10318546", "map_id": "A0A6I8SKD0", "name": "il16", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000031478", "map_id": "ENSXETG00000031478", "name": "il16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318552", "map_id": "F7BD23", "name": "CD4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10318554", "map_id": "none", "name": "CD4:IL16(1212-1332)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8SKD0", "map_id": "A0A6I8SKD0", "name": "il16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337036", "map_id": "none", "name": "IL34 dimer binds PTPRZ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10337032", "map_id": "A0A6I8QZW2", "name": "ptprz1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000022735", "map_id": "ENSXETG00000022735", "name": "ptprz1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337034", "map_id": "none", "name": "IL34 dimer:PTPRZ1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8QZW2", "map_id": "A0A6I8QZW2", "name": "ptprz1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318548", "map_id": "none", "name": "Interleukin-16 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10318541", "map_id": "A0A6I8SKD0", "name": "il16", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10318544", "map_id": "none", "name": "Caspase-3 cleaves pro-interleukin-16", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10318537", "map_id": "A0A6I8SKD0", "name": "il16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10318539", "map_id": "A0A6I8SKD0", "name": "il16", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10324152", "map_id": "none", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10324128", "map_id": "none", "name": "ISGylated 4EHP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8S9G6", "map_id": "A0A6I8S9G6", "name": "ube2l3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036095", "map_id": "ENSXETG00000036095", "name": "ube2l3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QSS2", "map_id": "A0A6I8QSS2", "name": "mgc89871", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000027885", "map_id": "ENSXETG00000027885", "name": "mgc89871", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10324148", "map_id": "none", "name": "eIF4F:mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SXK0", "map_id": "A0A6I8SXK0", "name": "eif4g1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000017287", "map_id": "ENSXETG00000017287", "name": "eif4g1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28ET8", "map_id": "Q28ET8", "name": "eif4e3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000015908", "map_id": "ENSXETG00000015908", "name": "eif4e3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7ZTW1", "map_id": "B7ZTW1", "name": "eif4a3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000030049", "map_id": "ENSXETT00000030049", "name": "eif4a3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6V5S1", "map_id": "F6V5S1", "name": "zcchc24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000039793", "map_id": "ENSXETT00000039793", "name": "zcchc24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10324146", "map_id": "none", "name": "EIF4F", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10324150", "map_id": "none", "name": "ISGylated 4EHP:mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10320256", "map_id": "none", "name": "UBP43 binds IFNAR2 and prevents JAK1 interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10320248", "map_id": "A0A6I8QPM9", "name": "IFNAR2-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000038384", "map_id": "ENSXETG00000038384", "name": "IFNGR1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320252", "map_id": "A0A6I8R9K6", "name": "usp18", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000034297", "map_id": "ENSXETG00000034297", "name": "usp18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320254", "map_id": "none", "name": "IFNAR2c:UBP43", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8R9K6", "map_id": "A0A6I8R9K6", "name": "usp18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QPM9", "map_id": "A0A6I8QPM9", "name": "IFNGR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10338086", "map_id": "none", "name": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10338082", "map_id": "none", "name": "IFNGR1:JAK1:INFGR2:JAK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PL76", "map_id": "A0A6I8PL76", "name": "il10rb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000030084", "map_id": "ENSXETG00000030084", "name": "il10rb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9678984", "map_id": "none", "name": "JAK1,2 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10338084", "map_id": "none", "name": "IFNGR1:JAK1:INFGR2:JAK2:JAK1,2 inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10315732", "map_id": "none", "name": "PLC-gamma1 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_112275", "map_id": "CHEBI:18035", "name": "DAGs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10315729", "map_id": "A0A6I8SLR0", "name": "phospho-plcg2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10317382", "map_id": "none", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10317356", "map_id": "none", "name": "BTLA interacts with HVEM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10317348", "map_id": "A0A6I8QYL7", "name": "BTLA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000040606", "map_id": "ENSXETG00000040606", "name": "phospho-p-Y226,Y257,Y282-BTLA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317352", "map_id": "A0A6I8PXQ3", "name": "tnfrsf14", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10317354", "map_id": "none", "name": "BTLA-HVEM complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8QYL7", "map_id": "A0A6I8QYL7", "name": "phospho-p-Y226,Y257,Y282-BTLA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317402", "map_id": "none", "name": "Grb2 binds pBTLA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10317398", "map_id": "none", "name": "p-BTLA-HVEM complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10312043", "map_id": "Q66II3", "name": "grb2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000027387", "map_id": "ENSXETT00000027387", "name": "grb2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317400", "map_id": "none", "name": "GRB2:pBTLA:HVEM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q66II3", "map_id": "Q66II3", "name": "grb2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10338149", "map_id": "none", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9678991", "map_id": "none", "name": "tacrolimus", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10338147", "map_id": "none", "name": "FKBP1A:tacrolimus", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10321852", "map_id": "none", "name": "NF-kappaB translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10321840", "map_id": "none", "name": "NF-kappaB p50,p65,c-Rel dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SJP9", "map_id": "A0A6I8SJP9", "name": "rel", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000002209", "map_id": "ENSXETG00000002209", "name": "rel", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10321850", "map_id": "none", "name": "NF-kappaB p50,p65,c-Rel dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10321828", "map_id": "none", "name": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312735", "map_id": "A8KBH6", "name": "prkcb", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312741", "map_id": "none", "name": "Activated PKC beta", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10316771", "map_id": "none", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10316762", "map_id": "none", "name": "RAP1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10316768", "map_id": "none", "name": "CalDAG-GEFs:DAG:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8S7H2", "map_id": "A0A6I8S7H2", "name": "rasgrp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040253", "map_id": "ENSXETG00000040253", "name": "rasgrp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317651", "map_id": "none", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10317648", "map_id": "A0A6I8PXJ9", "name": "sipa1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000034215", "map_id": "ENSXETG00000034215", "name": "sipa1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335085", "map_id": "none", "name": "BTNL2 binds activated T cells surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_8851965", "map_id": "none", "name": "Activated T Cell surface", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10335081", "map_id": "none", "name": "Homologues of BTNL2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8RCC8", "map_id": "A0A6I8RCC8", "name": "BTNL2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000021506", "map_id": "ENSXETT00000021506", "name": "BTNL2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SQD0", "map_id": "A0A6I8SQD0", "name": "btn1a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000030055", "map_id": "ENSXETG00000030055", "name": "btn1a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PY83", "map_id": "A0A6I8PY83", "name": "BTNL2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QRU2", "map_id": "A0A6I8QRU2", "name": "LOC101733331", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037889", "map_id": "ENSXETG00000037889", "name": "LOC101733331", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7AL17", "map_id": "F7AL17", "name": "BTNL2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "K9J7V7", "map_id": "K9J7V7", "name": "BTNL2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SWS4", "map_id": "A0A6I8SWS4", "name": "LOC100495215", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000041242", "map_id": "ENSXETG00000041242", "name": "LOC100495215", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8T2C4", "map_id": "A0A6I8T2C4", "name": "LOC101733623", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000006889", "map_id": "ENSXETG00000006889", "name": "LOC101733623", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335083", "map_id": "none", "name": "BTNL2: activated T Cell surface", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10334889", "map_id": "none", "name": "BTN2A1 binds DC-SIGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10334885", "map_id": "none", "name": "Homologues of BTN2A1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10329899", "map_id": "none", "name": "Homologues of CD209", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8T2E2", "map_id": "A0A6I8T2E2", "name": "CD209", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035088", "map_id": "ENSXETG00000035088", "name": "CD209", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SP31", "map_id": "A0A6I8SP31", "name": "fcer2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000012998", "map_id": "ENSXETG00000012998", "name": "fcer2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10334887", "map_id": "none", "name": "BTN2A1:CD209", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10336232", "map_id": "none", "name": "BTN3A1 and BTN1A1 binds periplakin (PPL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10336224", "map_id": "none", "name": "BTN3A1,BTN1A1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10336228", "map_id": "A0A6I8RD21", "name": "ppl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000009137", "map_id": "ENSXETG00000009137", "name": "ppl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10336230", "map_id": "none", "name": "BTN3A1,BTN1A1:PPL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8RD21", "map_id": "A0A6I8RD21", "name": "ppl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334949", "map_id": "none", "name": "BTN3A1 binds prenylated phosphoantigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_8851032", "map_id": "none", "name": "phosphoantigens (pAgs)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10334945", "map_id": "none", "name": "BTN3A1(BTN3A2,BTN3A3)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10334947", "map_id": "none", "name": "BTN3A1(BTN3A2,BTN3A3):pAgs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10335063", "map_id": "none", "name": "BTN2A2 binds T cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10335059", "map_id": "none", "name": "Homologues of BTN2A2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10335061", "map_id": "none", "name": "BTN2A2:activated T Cell surface", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10335041", "map_id": "none", "name": "BTNL9 binds immune cell surfaces", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_8851998", "map_id": "none", "name": "Immune Cell surface", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10335037", "map_id": "none", "name": "Homologues of BTNL9", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10335039", "map_id": "none", "name": "BTNL9:Immune cell surface", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10335107", "map_id": "none", "name": "BTNL8 binds resting T cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_8851976", "map_id": "none", "name": "Resting T Cell surface", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10335103", "map_id": "none", "name": "Homologues of BTNL8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10335105", "map_id": "none", "name": "BTNL8: resting T cell surface", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10326539", "map_id": "none", "name": "Formation of MHC II alpha beta heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane" }, { "id": "species_10326535", "map_id": "none", "name": "HLA II beta chain", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A6I8Q5N0", "map_id": "A0A6I8Q5N0", "name": "hla-dra", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040091", "map_id": "ENSXETG00000040091", "name": "hla-dra", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PRA1", "map_id": "A0A6I8PRA1", "name": "LOC100495183", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034043", "map_id": "ENSXETG00000034043", "name": "LOC100495183", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326509", "map_id": "none", "name": "HLA II alpha chain", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10326537", "map_id": "none", "name": "MHC II alpha beta heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10326006", "map_id": "none", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2213225", "map_id": "none", "name": "unfolded antigen", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2213226", "map_id": "none", "name": "MHC class II epitopes", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10326003", "map_id": "none", "name": "Cathepsin", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "A0A6I8RUR5", "map_id": "A0A6I8RUR5", "name": "LOC105948322", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035955", "map_id": "ENSXETG00000035955", "name": "LOC105948322", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QK05", "map_id": "A0A6I8QK05", "name": "ctsv", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000027581", "map_id": "ENSXETG00000027581", "name": "ctsv", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335318", "map_id": "none", "name": "LAG3 (CD233) binds MHC II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10335314", "map_id": "none", "name": "MHC class II alpha/beta dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10335260", "map_id": "A0A6I8PSX8", "name": "il1r2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000004981", "map_id": "ENSXETG00000004981", "name": "il1r2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335316", "map_id": "none", "name": "LAG3:MHC II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PSX8", "map_id": "A0A6I8PSX8", "name": "il1r2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326627", "map_id": "none", "name": "Loading of antigenic peptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10326623", "map_id": "none", "name": "peptide free MHC II:HLA-DM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10326625", "map_id": "none", "name": "peptide loaded MHC class II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10326567", "map_id": "none", "name": "HLA-DM/HLA-DO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10321631", "map_id": "none", "name": "Journey of cargo through Golgi complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13945", "compartment_display": "ER to Golgi transport vesicle membrane" }, { "id": "species_10321513", "map_id": "none", "name": "Antigen peptide bound class I MHC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13945", "compartment_display": "ER to Golgi transport vesicle membrane", "complex": "true" }, { "id": "CHEBI:59080", "map_id": "CHEBI:59080", "name": "CHEBI:59080", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10321629", "map_id": "none", "name": "Antigen peptide bound class I MHC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10321747", "map_id": "none", "name": "Expression of peptide bound class I MHC on cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10314568", "map_id": "none", "name": "Antigen peptide bound class I MHC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10322204", "map_id": "none", "name": "Export of peptide loaded MHC class I complex to PM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane" }, { "id": "species_10322202", "map_id": "none", "name": "Ag peptide bound class I MHC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10322086", "map_id": "none", "name": "Translocation of peptide bound MHC class I complex to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10322080", "map_id": "none", "name": "Antigen peptide bound class I MHC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_1236727", "map_id": "CHEBI:25676", "name": "Antigen peptide", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10322082", "map_id": "none", "name": "Loading of antigen peptide onto MHC class I molecule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171043", "compartment_display": "early endosome lumen" }, { "id": "species_10322078", "map_id": "none", "name": "Class I MHC:B2M", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10321964", "map_id": "none", "name": "Internalization of receptor bound antigen into clathrin coted vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10321942", "map_id": "none", "name": "MR:soluble antigen", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_1236715", "map_id": "CHEBI:16670", "name": "Exogenous soluble antigen", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "L7N3D8", "map_id": "L7N3D8", "name": "CD207", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000028489", "map_id": "ENSXETT00000028489", "name": "CD207", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10321962", "map_id": "none", "name": "MR:soluble antigen", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10322084", "map_id": "none", "name": "Movement of clathrin coated vesicles into early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10321920", "map_id": "none", "name": "MR:soluble antigen", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10321922", "map_id": "none", "name": "Exogenous soluble antigen targeted to more stable early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171043", "compartment_display": "early endosome lumen" }, { "id": "species_10321918", "map_id": "none", "name": "MR/other probable receptors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10321357", "map_id": "none", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10321345", "map_id": "none", "name": "E3:Ub:substrate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F7DJL8", "map_id": "F7DJL8", "name": "LOC100492142", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000025117", "map_id": "ENSXETT00000025117", "name": "LOC100492142", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7EP40", "map_id": "F7EP40", "name": "znrf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000016718", "map_id": "ENSXETT00000016718", "name": "znrf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S8J7", "map_id": "A0A6I8S8J7", "name": "siah1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000008090", "map_id": "ENSXETG00000008090", "name": "siah1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6P1V3", "map_id": "Q6P1V3", "name": "wsb1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000046179", "map_id": "ENSXETT00000046179", "name": "wsb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QHG5", "map_id": "A0A6I8QHG5", "name": "znrf2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039845", "map_id": "ENSXETG00000039845", "name": "znrf2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8T262", "map_id": "A0A6I8T262", "name": "spsb1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035671", "map_id": "ENSXETG00000035671", "name": "spsb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q07G42", "map_id": "Q07G42", "name": "rnf12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000004580", "map_id": "ENSXETG00000004580", "name": "rnf12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B4F6W9", "map_id": "B4F6W9", "name": "trip12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000085319", "map_id": "ENSXETT00000085319", "name": "trip12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S237", "map_id": "A0A6I8S237", "name": "RNF144B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034411", "map_id": "ENSXETG00000034411", "name": "RNF144B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S0I4", "map_id": "A0A6I8S0I4", "name": "rbx1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035313", "map_id": "ENSXETG00000035313", "name": "rbx1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6Y9J3", "map_id": "F6Y9J3", "name": "fbxo9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000073985", "map_id": "ENSXETT00000073985", "name": "fbxo9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RJ77", "map_id": "A0A6I8RJ77", "name": "FBXO6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036916", "map_id": "ENSXETG00000036916", "name": "FBXO6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SWC6", "map_id": "A0A6I8SWC6", "name": "cdrt1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031311", "map_id": "ENSXETG00000031311", "name": "cdrt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SN42", "map_id": "A0A6I8SN42", "name": "FBXO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036844", "map_id": "ENSXETG00000036844", "name": "FBXO2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6ZT52", "map_id": "F6ZT52", "name": "poc1b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000091115", "map_id": "ENSXETT00000091115", "name": "poc1b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q4I3", "map_id": "A0A6I8Q4I3", "name": "fbxl22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038110", "map_id": "ENSXETG00000038110", "name": "fbxl22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7CA07", "map_id": "F7CA07", "name": "fbxw2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000042434", "map_id": "ENSXETT00000042434", "name": "fbxw2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B2GUS9", "map_id": "B2GUS9", "name": "fbxl8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000063698", "map_id": "ENSXETT00000063698", "name": "fbxl8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5XGI3", "map_id": "Q5XGI3", "name": "fbxl5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000020331", "map_id": "ENSXETG00000020331", "name": "fbxl5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R265", "map_id": "A0A6I8R265", "name": "fbxo40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000030638", "map_id": "ENSXETG00000030638", "name": "fbxo40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5XGG5", "map_id": "Q5XGG5", "name": "ccnf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000027235", "map_id": "ENSXETT00000027235", "name": "ccnf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0D2D2", "map_id": "Q0D2D2", "name": "fbxo31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000037873", "map_id": "ENSXETT00000037873", "name": "fbxo31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PWZ7", "map_id": "A0A6I8PWZ7", "name": "fbxo27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039521", "map_id": "ENSXETG00000039521", "name": "fbxo27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6TXL5", "map_id": "F6TXL5", "name": "SKP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000035098", "map_id": "ENSXETT00000035098", "name": "SKP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RA00", "map_id": "A0A6I8RA00", "name": "mib2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000019608", "map_id": "ENSXETG00000019608", "name": "mib2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10321339", "map_id": "none", "name": "Ubiquitin:E2 conjugating enzymes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6GL05", "map_id": "Q6GL05", "name": "ube2a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000101990", "map_id": "ENSXETT00000101990", "name": "ube2a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10321352", "map_id": "none", "name": "E3:K48-polyubiquitinated substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10321337", "map_id": "none", "name": "E2 Ubiquitin-conjugating enzyme", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10321359", "map_id": "none", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10321281", "map_id": "none", "name": "E3 ligases in proteasomal degradation", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_983035", "map_id": "none", "name": "antigenic substrate", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10321341", "map_id": "none", "name": "Ag-substrate:E3:E2:Ub", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10321354", "map_id": "none", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_983123", "map_id": "none", "name": "K48polyUb-antigenic substrate", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10321348", "map_id": "none", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10334525", "map_id": "none", "name": "BPI binds LPS on the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6803081", "map_id": "CHEBI:16412", "name": "LPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222574", "compartment_display": "cell wall", "complex": "false" }, { "id": "species_10313204", "map_id": "A0A6I8REW5", "name": "bpi.4", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000017331", "map_id": "ENSXETG00000017331", "name": "bpi.4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10334523", "map_id": "none", "name": "BPI:LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8REW5", "map_id": "A0A6I8REW5", "name": "bpi.4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_166005", "map_id": "CHEBI:16412", "name": "LPS", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10333951", "map_id": "none", "name": "REG3A oligomerize to form a pore complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10333945", "map_id": "none", "name": "REG3A(38-175):anionic phospholipids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:62643", "map_id": "CHEBI:62643", "name": "CHEBI:62643", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PQ14", "map_id": "A0A6I8PQ14", "name": "reg4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033383", "map_id": "ENSXETG00000033383", "name": "reg4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10333949", "map_id": "none", "name": "REG3A hexamer:anionic phospholipid", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10321873", "map_id": "none", "name": "Lactoferrin scavenges iron ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen" }, { "id": "species_2101051", "map_id": "CHEBI:41609", "name": "CO3(2-)", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1222611", "map_id": "CHEBI:29034", "name": "Fe3+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_10321869", "map_id": "Q501K5", "name": "tf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_10321871", "map_id": "none", "name": "LTF:2xFe3+:2xCO3(2-)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "reaction_10333978", "map_id": "none", "name": "RNASEs bind bacterial LPS, PGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10333974", "map_id": "none", "name": "RNASE3,RNASE7,RNASE6,(RNASE8)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8R6T7", "map_id": "A0A6I8R6T7", "name": "RNASE3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038487", "map_id": "ENSXETG00000038487", "name": "RNASE3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6803074", "map_id": "none", "name": "LPS, PGN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222574", "compartment_display": "cell wall", "complex": "true" }, { "id": "CHEBI:55478", "map_id": "CHEBI:55478", "name": "CHEBI:55478", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6789198", "map_id": "CHEBI:55424", "name": "GlcNac-(1-->4)MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10333976", "map_id": "none", "name": "RNASEs 3,6,7,(8):LPS,PGN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10334646", "map_id": "none", "name": "ELANE, CTSG or PRTN3 binds bacteria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10334642", "map_id": "none", "name": "ELANE, CTSG, PRTN3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8RBC3", "map_id": "A0A6I8RBC3", "name": "cela1.5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037351", "map_id": "ENSXETG00000037351", "name": "cela1.5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5HZU5", "map_id": "Q5HZU5", "name": "cela1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000093455", "map_id": "ENSXETT00000093455", "name": "cela1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QPJ5", "map_id": "A0A6I8QPJ5", "name": "cela1.6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039590", "map_id": "ENSXETG00000039590", "name": "cela1.6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7EHU5", "map_id": "F7EHU5", "name": "ctsg", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000037000", "map_id": "ENSXETT00000037000", "name": "ctsg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8879165", "map_id": "none", "name": "Microbial cell surface", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10334644", "map_id": "none", "name": "ELANE,CTSG, PRTN3:microbial cell surface", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10334033", "map_id": "none", "name": "INTL1 binds bacterial glycans", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10334029", "map_id": "none", "name": "ITLN1 trimer:Ca2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "F7BS21", "map_id": "F7BS21", "name": "itln1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000047100", "map_id": "ENSXETT00000047100", "name": "itln1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6804535", "map_id": "none", "name": "INTL1 ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222574", "compartment_display": "cell wall", "complex": "true" }, { "id": "CHEBI:42976", "map_id": "CHEBI:42976", "name": "CHEBI:42976", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:59496", "map_id": "CHEBI:59496", "name": "CHEBI:59496", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:85986", "map_id": "CHEBI:85986", "name": "CHEBI:85986", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10334031", "map_id": "none", "name": "INTL1:bacterial glycan", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10334640", "map_id": "none", "name": "LEAP2 binds bacteria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10334636", "map_id": "A0A6I8QY26", "name": "leap2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000030080", "map_id": "ENSXETG00000030080", "name": "leap2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8931784", "map_id": "none", "name": "Anionic phospholipids:microbial cell surface", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10334638", "map_id": "none", "name": "LEAP2:bacterial phospholipids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8QY26", "map_id": "A0A6I8QY26", "name": "leap2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10333966", "map_id": "none", "name": "REG3A,REG3G binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10333943", "map_id": "A0A6I8PQ14", "name": "reg4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10333964", "map_id": "none", "name": "REG3A(38-175), REG3G(38-175):peptidoglycan", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10333960", "map_id": "none", "name": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10333953", "map_id": "A0A6I8PQ14", "name": "reg4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10333955", "map_id": "A0A6I8PQ14", "name": "reg4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10333957", "map_id": "none", "name": "Trypsin 2, 3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "F7A271", "map_id": "F7A271", "name": "plat", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000036622", "map_id": "ENSXETT00000036622", "name": "plat", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R8N0", "map_id": "A0A6I8R8N0", "name": "LOC105945797", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000026148", "map_id": "ENSXETG00000026148", "name": "LOC105945797", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336840", "map_id": "none", "name": "RNASEs bind bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10336838", "map_id": "none", "name": "RNASEs 3,6,7,(8):anionic phospholipids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10333962", "map_id": "none", "name": "REG3A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10335621", "map_id": "none", "name": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10335616", "map_id": "none", "name": "LYZ:PGN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8RID5", "map_id": "A0A6I8RID5", "name": "lyz", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037293", "map_id": "ENSXETG00000037293", "name": "lyz", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6788991", "map_id": "none", "name": "MurNAc:Peptide", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222574", "compartment_display": "cell wall", "complex": "true" }, { "id": "CHEBI:21615", "map_id": "CHEBI:21615", "name": "CHEBI:21615", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6788982", "map_id": "CHEBI:28009", "name": "betaGlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222574", "compartment_display": "cell wall", "complex": "false" }, { "id": "reaction_10334628", "map_id": "none", "name": "PI3 binds the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10334624", "map_id": "none", "name": "PI3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8RZ58", "map_id": "A0A6I8RZ58", "name": "PI3(23-117)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038864", "map_id": "ENSXETG00000038864", "name": "PI3(23-117)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QJ14", "map_id": "A0A6I8QJ14", "name": "XB22169518", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036342", "map_id": "ENSXETG00000036342", "name": "XB22169518", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10334626", "map_id": "none", "name": "PI3:LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10333638", "map_id": "none", "name": "PGLYRP3,4 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10333634", "map_id": "none", "name": "PGLYRP3,4 dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q5BKE6", "map_id": "Q5BKE6", "name": "pglyrp1-like.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000089406", "map_id": "ENSXETT00000089406", "name": "pglyrp1-like.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10333636", "map_id": "none", "name": "PGLYRP3,4 dimer:peptidoglycan", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10332387", "map_id": "none", "name": "PGLYRP1 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen" }, { "id": "species_10332383", "map_id": "none", "name": "PGLYRP1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "species_10332385", "map_id": "none", "name": "PGLYRP1dimer:peptidoglycan", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "species_1562550", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "reaction_10335618", "map_id": "none", "name": "LYZ binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10332888", "map_id": "A0A6I8RID5", "name": "lyz", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10327260", "map_id": "none", "name": "STING dimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10326753", "map_id": "none", "name": "STING:STING", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10327352", "map_id": "none", "name": "STING binds cyclic GMP-AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_3244587", "map_id": "CHEBI:71580", "name": "c-GMP-AMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10327350", "map_id": "none", "name": "STING:cGAMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "reaction_10326762", "map_id": "none", "name": "STING binds c-di-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2395973", "map_id": "CHEBI:49537", "name": "c-di-GMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10326760", "map_id": "none", "name": "STING:c-di-GMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "reaction_10337738", "map_id": "none", "name": "NFkB complex translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10329903", "map_id": "none", "name": "CD209 binds ICAM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10314660", "map_id": "none", "name": "Homologues of ICAM2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PWA4", "map_id": "A0A6I8PWA4", "name": "icam5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000027690", "map_id": "ENSXETG00000027690", "name": "icam5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q7U5", "map_id": "A0A6I8Q7U5", "name": "ICAM2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000022064", "map_id": "ENSXETG00000022064", "name": "ICAM2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10329901", "map_id": "none", "name": "CD209:ICAM2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10330318", "map_id": "none", "name": "p-S276-RELA binds RELB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10330314", "map_id": "A0A6I8PZ90", "name": "relb", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000031521", "map_id": "ENSXETG00000031521", "name": "relb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10329932", "map_id": "A0A6I8PS73", "name": "phospho-rela", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10330316", "map_id": "none", "name": "p-S276-RELA:RELB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8PZ90", "map_id": "A0A6I8PZ90", "name": "relb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329907", "map_id": "none", "name": "CD209 binds ICAM3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10314666", "map_id": "none", "name": "Homologues of ICAM3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10329905", "map_id": "none", "name": "CD209:ICAM3:Ca+2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10329834", "map_id": "none", "name": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10329832", "map_id": "A0A6I8SLR0", "name": "phospho-plcg2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10329827", "map_id": "A0A6I8SLR0", "name": "phospho-plcg2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10329830", "map_id": "none", "name": "p-Y753,Y759-PLCG2 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10335614", "map_id": "none", "name": "CLEC10A binds Tn-MUC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10335610", "map_id": "none", "name": "Tn antigens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10335598", "map_id": "A0A6I8Q6M7", "name": "LOC100493006", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000041320", "map_id": "ENSXETG00000041320", "name": "LOC100493006", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335612", "map_id": "none", "name": "CLEC10A:Tn antigens", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8Q6M7", "map_id": "A0A6I8Q6M7", "name": "LOC100493006", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10332377", "map_id": "none", "name": "HV1-mediated H+ transfer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1470067", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_10332374", "map_id": "none", "name": "HV1 channel", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "Q5M8L8", "map_id": "Q5M8L8", "name": "hvcn1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000045238", "map_id": "ENSXETT00000045238", "name": "hvcn1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317728", "map_id": "none", "name": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29968", "map_id": "CHEBI:16349", "name": "L-Cit", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10313407", "map_id": "none", "name": "Secreted CD14 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10313202", "map_id": "none", "name": "LBP:bacterial LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8QVF2", "map_id": "A0A6I8QVF2", "name": "LOC100494799", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038104", "map_id": "ENSXETG00000038104", "name": "LOC100494799", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QHS4", "map_id": "A0A6I8QHS4", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037015", "map_id": "ENSXETG00000037015", "name": "LBP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10313403", "map_id": "A0A6I8PVH6", "name": "CD14(20-345)", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000031516", "map_id": "ENSXETG00000031516", "name": "GPIN-CD14(20-345)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10313200", "map_id": "none", "name": "Homologues of LBP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10313405", "map_id": "none", "name": "LPS:secreted CD14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8PVH6", "map_id": "A0A6I8PVH6", "name": "GPIN-CD14(20-345)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10313216", "map_id": "none", "name": "GPI-bound CD14 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10313212", "map_id": "A0A6I8PVH6", "name": "GPIN-CD14(20-345)", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10313214", "map_id": "none", "name": "LPS:GPI-anchored CD14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10326889", "map_id": "none", "name": "TIRAP binds PIP2-rich regions in the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10326885", "map_id": "A0A6I8QHE1", "name": "LOC100491693", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000031764", "map_id": "ENSXETG00000031764", "name": "LOC100491693", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326887", "map_id": "none", "name": "TIRAP:PI(4,5)P2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8QHE1", "map_id": "A0A6I8QHE1", "name": "LOC100491693", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10313206", "map_id": "none", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10335885", "map_id": "none", "name": "oxPL binds CD14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10335883", "map_id": "none", "name": "CD14:oxPL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10335881", "map_id": "none", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10335879", "map_id": "none", "name": "LBP:oxPL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10313401", "map_id": "none", "name": "Ligand binds to TLR10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10313395", "map_id": "A0A6I8PMY8", "name": "tlr6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000018477", "map_id": "ENSXETG00000018477", "name": "tlr6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_168948", "map_id": "none", "name": "Ligand recognized by TLR10", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10313399", "map_id": "none", "name": "TLR10 homodimer bound to ligand", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PMY8", "map_id": "A0A6I8PMY8", "name": "tlr6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324331", "map_id": "none", "name": "Cross-linking of FCGRIIA with IgG-coated Ag", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10324321", "map_id": "none", "name": "Antigen:IgG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10324327", "map_id": "none", "name": "Homologues of FCGR2A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10324329", "map_id": "none", "name": "IgG-Ag:FCGRIIA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10326828", "map_id": "none", "name": "Interaction of DAP12 and IREM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10326824", "map_id": "A0A6I8SNS8", "name": "CD300E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10316092", "map_id": "none", "name": "DAP12 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8QP54", "map_id": "A0A6I8QP54", "name": "tyrobp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039786", "map_id": "ENSXETG00000039786", "name": "tyrobp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326826", "map_id": "none", "name": "IREM2:DAP12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10316104", "map_id": "none", "name": "Interaction of DAP12 and TREM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10316100", "map_id": "A0A6I8QSY3", "name": "TREM2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10316102", "map_id": "none", "name": "DAP12 dimer:TREM2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10326264", "map_id": "none", "name": "Interaction of SIGLEC14/15/16 and DAP12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10326260", "map_id": "none", "name": "SIGLEC14/15/16", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8Q2E3", "map_id": "A0A6I8Q2E3", "name": "SIGLEC15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031297", "map_id": "ENSXETG00000031297", "name": "SIGLEC15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326262", "map_id": "none", "name": "SIGLEC14/15/16:DAP12 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10326651", "map_id": "none", "name": "Interaction of DAP12 and KIR2DS5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10315610", "map_id": "A0A6I8Q0D7", "name": "KIR2DS2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10326649", "map_id": "none", "name": "KIR2DS5:DAP12 dimer:KIR2DS5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10325991", "map_id": "none", "name": "Dimerization of DAP12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10315608", "map_id": "A0A6I8QP54", "name": "tyrobp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10326822", "map_id": "none", "name": "Interaction of DAP12 and CLM7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10326818", "map_id": "A0A6I8SNS8", "name": "CD300LB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10326820", "map_id": "none", "name": "CLM7:DAP12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10316096", "map_id": "none", "name": "Interaction of DAP12 and NKp44", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10316090", "map_id": "A0A6I8PSB6", "name": "trem2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10316094", "map_id": "none", "name": "DAP12:NKp44", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10320644", "map_id": "none", "name": "NLRX1 inhibits MAVS-DDX58 interaction.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10320640", "map_id": "A0A6I8PYZ4", "name": "nlrx1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "ENSXETG00000021586", "map_id": "ENSXETG00000021586", "name": "nlrx1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320636", "map_id": "A0A6I8PQE8", "name": "MAVS", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "ENSXETG00000032111", "map_id": "ENSXETG00000032111", "name": "MAVS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320642", "map_id": "none", "name": "MAVS:NLRX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "A0A6I8PQE8", "map_id": "A0A6I8PQE8", "name": "MAVS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PYZ4", "map_id": "A0A6I8PYZ4", "name": "nlrx1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10338275", "map_id": "none", "name": "MAVS binds TOMM70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10331987", "map_id": "A0A6I8QP49", "name": "tomm70", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "ENSXETG00000011867", "map_id": "ENSXETG00000011867", "name": "tomm70", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10338273", "map_id": "none", "name": "MAVS:TOMM70", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "A0A6I8QP49", "map_id": "A0A6I8QP49", "name": "tomm70", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10333758", "map_id": "none", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6800424", "compartment_display": "ficolin-1-rich granule membrane" }, { "id": "species_10333750", "map_id": "none", "name": "Ficolin-rich granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6800424", "compartment_display": "ficolin-1-rich granule membrane", "complex": "true" }, { "id": "A0A6I8PUI6", "map_id": "A0A6I8PUI6", "name": "CLEC4D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037491", "map_id": "ENSXETG00000037491", "name": "CLEC4D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QHU4", "map_id": "A0A6I8QHU4", "name": "atp6ap2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000015523", "map_id": "ENSXETG00000015523", "name": "atp6ap2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SYN8", "map_id": "A0A6I8SYN8", "name": "ITGAM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035544", "map_id": "ENSXETG00000035544", "name": "ITGAM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q475", "map_id": "A0A6I8Q475", "name": "ITGAM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PQG1", "map_id": "A0A6I8PQG1", "name": "dsg2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034243", "map_id": "ENSXETG00000034243", "name": "dsg2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QZT4", "map_id": "A0A6I8QZT4", "name": "tcirg1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000015766", "map_id": "ENSXETG00000015766", "name": "tcirg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6WCE6", "map_id": "F6WCE6", "name": "adamts4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6NVR9", "map_id": "Q6NVR9", "name": "atad3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000028394", "map_id": "ENSXETT00000028394", "name": "atad3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SS44", "map_id": "A0A6I8SS44", "name": "stbd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034408", "map_id": "ENSXETG00000034408", "name": "stbd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1A5G6", "map_id": "A1A5G6", "name": "atp6v0a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000007635", "map_id": "ENSXETG00000007635", "name": "atp6v0a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SM80", "map_id": "A0A6I8SM80", "name": "FPR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000041332", "map_id": "ENSXETG00000041332", "name": "FPR1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SWF4", "map_id": "A0A6I8SWF4", "name": "FPR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q632", "map_id": "A0A6I8Q632", "name": "FPR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q814", "map_id": "A0A6I8Q814", "name": "FPR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0VA77", "map_id": "Q0VA77", "name": "enpp4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000035499", "map_id": "ENSXETT00000035499", "name": "enpp4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6P8C8", "map_id": "Q6P8C8", "name": "arl8a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000001981", "map_id": "ENSXETT00000001981", "name": "arl8a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6WSE4", "map_id": "F6WSE4", "name": "CD97", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000003359", "map_id": "ENSXETT00000003359", "name": "CD97", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10333756", "map_id": "none", "name": "Ficolin-rich granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10333460", "map_id": "none", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1470028", "compartment_display": "azurophil granule lumen" }, { "id": "species_10333416", "map_id": "none", "name": "Azurophil granule lumen proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1470028", "compartment_display": "azurophil granule lumen", "complex": "true" }, { "id": "Q6DIW0", "map_id": "Q6DIW0", "name": "C6ORF120", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000053781", "map_id": "ENSXETT00000053781", "name": "C6ORF120", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PNH6", "map_id": "A0A6I8PNH6", "name": "DYNC1H1", "type": "complex_component", "sub_type": 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SLF2", "map_id": "A0A6I8SLF2", "name": "LOC101731406", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037404", "map_id": "ENSXETG00000037404", "name": "LOC101731406", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PQQ3", "map_id": "A0A6I8PQQ3", "name": "PLAUR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033079", "map_id": "ENSXETG00000033079", "name": "PLAUR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PVI0", "map_id": "A0A6I8PVI0", "name": "adam10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000010850", "map_id": "ENSXETG00000010850", "name": "adam10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6ZRG8", "map_id": "F6ZRG8", "name": "cyba", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000037913", "map_id": "ENSXETT00000037913", "name": "cyba", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0BM39", "map_id": "B0BM39", "name": "tspan9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000065869", "map_id": "ENSXETT00000065869", "name": "tspan9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q68FB8", "map_id": "Q68FB8", "name": "degs1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6Z744", "map_id": "F6Z744", "name": "AP1M1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000019976", "map_id": "ENSXETT00000019976", "name": "AP1M1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PZB2", "map_id": "A0A6I8PZB2", "name": "atp11a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000001905", "map_id": "ENSXETG00000001905", "name": "atp11a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10333600", "map_id": "none", "name": "Specific granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10332898", "map_id": "none", "name": "Exocytosis of tertiary granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6800173", "compartment_display": "tertiary granule lumen" }, { "id": "species_10332852", "map_id": "none", "name": "Tertiary granule lumen proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6800173", "compartment_display": "tertiary granule lumen", "complex": "true" }, { "id": "species_10332896", "map_id": "none", "name": "Tertiary granule lumen proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10333042", "map_id": "none", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6799713", "compartment_display": "tertiary granule membrane" }, { "id": "species_10333006", "map_id": "none", "name": "Tertiary granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6799713", "compartment_display": "tertiary granule membrane", "complex": "true" }, { "id": "F6TV21", "map_id": "F6TV21", "name": "diras2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000001805", "map_id": "ENSXETT00000001805", "name": "diras2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28H62", "map_id": "Q28H62", "name": "cystm1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000054186", "map_id": "ENSXETT00000054186", "name": "cystm1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10333040", "map_id": "none", "name": "Tertiary granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10320878", "map_id": "none", "name": "C4b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10313268", "map_id": "none", "name": "C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8Q4R4", "map_id": "A0A6I8Q4R4", "name": "c4a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000005203", "map_id": "ENSXETG00000005203", "name": "c4a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_983438", "map_id": "none", "name": "Cell surface", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10313290", "map_id": "none", "name": "Cell surface:C4b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10313294", "map_id": "none", "name": "Formation of Classical C3 convertase (C4b:C2a complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10313274", "map_id": "A0A6I8R253", "name": "c2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000041348", "map_id": "ENSXETG00000041348", "name": "c2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10313292", "map_id": "none", "name": "Cell surface:C4b:C2a", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8R253", "map_id": "A0A6I8R253", "name": "c2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10313469", "map_id": "none", "name": "Factor D cleaves C3(H2O)-bound Factor B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10313458", "map_id": "none", "name": "C3(H2O):CFB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8S693", "map_id": "A0A6I8S693", "name": "cfb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039379", "map_id": "ENSXETG00000039379", "name": "cfb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10313462", "map_id": "A0A6I8S693", "name": "cfb", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10313320", "map_id": "none", "name": "C3(H2O):Bb", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10313466", "map_id": "Q6P326", "name": "ami", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10313981", "map_id": "none", "name": "Factor B binds to surface-associated C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10313456", "map_id": "A0A6I8S693", "name": "cfb", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10313326", "map_id": "none", "name": "Cell surface:C3b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10313977", "map_id": "none", "name": "Cell surface:C3b:CFB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10320876", "map_id": "none", "name": "C3b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10313307", "map_id": "none", "name": "C3b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10313454", "map_id": "none", "name": "Spontaneous hydrolysis of C3 thioester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10313303", "map_id": "none", "name": "Complement factor 3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10313314", "map_id": "none", "name": "C3(H2O)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10313979", "map_id": "none", "name": "Factor D cleaves C3b-bound Factor B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10313324", "map_id": "none", "name": "Cell surface:C3b:Bb", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10313460", "map_id": "none", "name": "Factor B binds to C3(H2O)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10313984", "map_id": "none", "name": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10313309", "map_id": "A0A6I8Q3I4", "name": "LOC100170611", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10334989", "map_id": "none", "name": "CFHR dimers bind C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10334985", "map_id": "none", "name": "CFHR dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8PQF3", "map_id": "A0A6I8PQF3", "name": "f13b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031728", "map_id": "ENSXETG00000031728", "name": "f13b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10334987", "map_id": "none", "name": "Cell surface:C3b:CFHR dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10321772", "map_id": "none", "name": "Factor H binds host cell surface markers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10320787", "map_id": "A0A6I8PQF3", "name": "f13b", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_1006146", "map_id": "none", "name": "Host cell surface", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_1604784", "map_id": "CHEBI:24505", "name": "Heparins", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10320851", "map_id": "none", "name": "CFH:Host cell surface", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10320856", "map_id": "none", "name": "Factor H displaces Bb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10320849", "map_id": "none", "name": "Cell surface:CFH, CFHR3:C3bBb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10313318", "map_id": "A0A6I8S693", "name": "cfb", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10320847", "map_id": "none", "name": "Cell surface:FH,FHR3:C3b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10320853", "map_id": "none", "name": "Factor H binds to C3bBb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10320791", "map_id": "none", "name": "Factor H binds to C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10320789", "map_id": "none", "name": "CFH:C3b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10320880", "map_id": "none", "name": "Factor H binds to membrane-associated C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10327043", "map_id": "none", "name": "Hydrolysis of internal thioester in C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10313281", "map_id": "none", "name": "deamidated-Q1013-C4A-derived C4b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10313452", "map_id": "none", "name": "Formation of classic pathway C5 convertase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10313328", "map_id": "none", "name": "C4b:C2a:C3b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10313333", "map_id": "none", "name": "Cleavage of C3 by C3 convertases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10313330", "map_id": "none", "name": "C3 convertases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10337951", "map_id": "none", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337948", "map_id": "none", "name": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "B5DE70", "map_id": "B5DE70", "name": "tifa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000052013", "map_id": "ENSXETT00000052013", "name": "tifa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QX94", "map_id": "A0A6I8QX94", "name": "alpk1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000024103", "map_id": "ENSXETG00000024103", "name": "alpk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9645519", "map_id": "CHEBI:15915", "name": "ADP-heptose", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10337966", "map_id": "none", "name": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10320680", "map_id": "Q28DL4", "name": "traf6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10337964", "map_id": "none", "name": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10337953", "map_id": "none", "name": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10337976", "map_id": "none", "name": "ALPK1:ADP-heptose binds TIFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337937", "map_id": "none", "name": "ALPK1:ADP heptose", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10337972", "map_id": "none", "name": "TIFA:TIFA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10337974", "map_id": "none", "name": "ALPK1:ADP-heptose:TIFA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10337979", "map_id": "none", "name": "ALPK1 phosphorylates TIFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337960", "map_id": "none", "name": "ALPK1:ADP-heptose:p-T9-TIFA dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10337962", "map_id": "none", "name": "TIFA oligomerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337946", "map_id": "none", "name": "ALPK1:ADP-heptose:p-T9-TIFA oligomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10337956", "map_id": "none", "name": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10337958", "map_id": "none", "name": "ALPK1 binds ADP-heptose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337935", "map_id": "A0A6I8QX94", "name": "alpk1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337968", "map_id": "none", "name": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10330607", "map_id": "none", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10324029", "map_id": "A0A6I8QJY3", "name": "mtmr3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10330623", "map_id": "none", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane" }, { "id": "species_10330602", "map_id": "none", "name": "LC3:PE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "Q5BIZ2", "map_id": "Q5BIZ2", "name": "gabarapl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000083554", "map_id": "ENSXETT00000083554", "name": "gabarapl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28FC7", "map_id": "Q28FC7", "name": "map1lc3c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000085573", "map_id": "ENSXETT00000085573", "name": "map1lc3c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330621", "map_id": "none", "name": "LC3:PE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane", "complex": "true" }, { "id": "species_10320527", "map_id": "none", "name": "ESCRT-III", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q5FW14", "map_id": "Q5FW14", "name": "chmp7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000016810", "map_id": "ENSXETG00000016810", "name": "chmp7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5BKM3", "map_id": "Q5BKM3", "name": "chmp3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000038990", "map_id": "ENSXETT00000038990", "name": "chmp3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6NVL7", "map_id": "Q6NVL7", "name": "chmp2b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000016617", "map_id": "ENSXETT00000016617", "name": "chmp2b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6DFS6", "map_id": "Q6DFS6", "name": "chmp2a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000041697", "map_id": "ENSXETT00000041697", "name": "chmp2a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6GL11", "map_id": "Q6GL11", "name": "chmp4b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000021424", "map_id": "ENSXETG00000021424", "name": "chmp4b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336858", "map_id": "none", "name": "p-S13-FUNDC1 is dephosphorylated by PGAM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10336847", "map_id": "B1H3B1", "name": "phospho-fundc1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "ENSXETG00000004831", "map_id": "ENSXETG00000004831", "name": "phospho-fundc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10336844", "map_id": "B1H3B1", "name": "fundc1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10336855", "map_id": "Q6GL33", "name": "pgam5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "ENSXETG00000023845", "map_id": "ENSXETG00000023845", "name": "pgam5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336851", "map_id": "none", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10330653", "map_id": "A0A6I8QPJ0", "name": "ulk1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10336849", "map_id": "A0A6I8QPJ0", "name": "ulk1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10336867", "map_id": "none", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10336864", "map_id": "B1H3B1", "name": "phospho-fundc1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10330657", "map_id": "none", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10330651", "map_id": "none", "name": "p-S758-ULK1:ATG13:RB1CC1:ATG101", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8QPJ0", "map_id": "A0A6I8QPJ0", "name": "ulk1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A4IIM9", "map_id": "A4IIM9", "name": "atg13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000004248", "map_id": "ENSXETT00000004248", "name": "atg13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330655", "map_id": "none", "name": "ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10337853", "map_id": "none", "name": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10337843", "map_id": "A0A6I8Q015", "name": "neil3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000030606", "map_id": "ENSXETG00000030606", "name": "neil3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337849", "map_id": "none", "name": "Gh-Telomeric DNA:Shelterin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q28D37", "map_id": "Q28D37", "name": "HIST3H3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000104494", "map_id": "ENSXETT00000104494", "name": "HIST3H3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B8QB46", "map_id": "B8QB46", "name": "terf2ip", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000012487", "map_id": "ENSXETG00000012487", "name": "terf2ip", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PVF6", "map_id": "A0A6I8PVF6", "name": "terf2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031339", "map_id": "ENSXETG00000031339", "name": "terf2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7E8S9", "map_id": "F7E8S9", "name": "terf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000020406", "map_id": "ENSXETT00000020406", "name": "terf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337851", "map_id": "none", "name": "NEIL3:Gh-Telomeric DNA:Shelterin", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8Q015", "map_id": "A0A6I8Q015", "name": "neil3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337864", "map_id": "none", "name": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10337861", "map_id": "none", "name": "NEIL3:AP-Telomeric DNA:Shelterin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_9629218", "map_id": "CHEBI:142614", "name": "Gh", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10312491", "map_id": "none", "name": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10312486", "map_id": "none", "name": "MUTYH:(8oxoG:Ade)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8QBS0", "map_id": "A0A6I8QBS0", "name": "mutyh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000003533", "map_id": "ENSXETG00000003533", "name": "mutyh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5635947", "map_id": "CHEBI:16708", "name": "Ade", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10312488", "map_id": "none", "name": "MUTYH:AP-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10337882", "map_id": "none", "name": "NEIL3 cleaves spiroiminodihydantoin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10337879", "map_id": "none", "name": "NEIL3:Sp-DNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_9629439", "map_id": "CHEBI:142623", "name": "Sp", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10337872", "map_id": "none", "name": "NEIL3:AP-DNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10337875", "map_id": "none", "name": "NEIL3 cleaves 5-guanidinohydantoin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10337868", "map_id": "none", "name": "NEIL3:Gh-DNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10328441", "map_id": "none", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10327136", "map_id": "none", "name": "SUMO1:C93-UBE2I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q6DEP7", "map_id": "Q6DEP7", "name": "sumo1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000022072", "map_id": "ENSXETG00000022072", "name": "sumo1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328439", "map_id": "none", "name": "SUMO1:K14-UBE2I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10328589", "map_id": "none", "name": "SUMOylation of TDG with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10312379", "map_id": "A0A6I8RWH5", "name": "tdg", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000025927", "map_id": "ENSXETG00000025927", "name": "tdg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328587", "map_id": "none", "name": "SUMO1:TDG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8RWH5", "map_id": "A0A6I8RWH5", "name": "tdg", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328620", "map_id": "none", "name": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328610", "map_id": "A8WH10", "name": "xrcc4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000057859", "map_id": "ENSXETT00000057859", "name": "xrcc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328618", "map_id": "none", "name": "SUMO1:XRCC4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A8WH10", "map_id": "A8WH10", "name": "xrcc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328508", "map_id": "A0A6I8Q277", "name": "pias2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000021519", "map_id": "ENSXETG00000021519", "name": "pias2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327230", "map_id": "none", "name": "SUMOylation of PML with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10327188", "map_id": "A0A6I8SBS8", "name": "LOC100488610", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10327227", "map_id": "A0A6I8SBS8", "name": "LOC100488610", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10328606", "map_id": "none", "name": "SUMOylation of TDG with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328443", "map_id": "none", "name": "UBE2I:SUMO2,UBE2I:SUMO3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q28H04", "map_id": "Q28H04", "name": "sumo2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000027383", "map_id": "ENSXETT00000027383", "name": "sumo2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328604", "map_id": "A0A6I8RWH5", "name": "tdg", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10328632", "map_id": "none", "name": "SUMOylation of RAD52 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328630", "map_id": "none", "name": "3SUMO1:RAD52", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10328682", "map_id": "none", "name": "SUMOylation of MDC1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328677", "map_id": "A0A6I8SUQ0", "name": "mdc1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000039209", "map_id": "ENSXETG00000039209", "name": "mdc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328680", "map_id": "A0A6I8SUQ0", "name": "mdc1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10328644", "map_id": "none", "name": "SUMOylation of BLM with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328636", "map_id": "A0A6I8PXE0", "name": "blm", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000007847", "map_id": "ENSXETG00000007847", "name": "blm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328642", "map_id": "A0A6I8PXE0", "name": "blm", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10328692", "map_id": "none", "name": "SUMOylation of MDC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328690", "map_id": "none", "name": "SUMO1:MDC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8SUQ0", "map_id": "A0A6I8SUQ0", "name": "mdc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327201", "map_id": "none", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10327198", "map_id": "none", "name": "3SUMO1:PML", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10328673", "map_id": "none", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328663", "map_id": "A0A6I8PUF7", "name": "xpc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000033244", "map_id": "ENSXETG00000033244", "name": "xpc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328671", "map_id": "none", "name": "SUMO1:XPC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8PUF7", "map_id": "A0A6I8PUF7", "name": "xpc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328579", "map_id": "none", "name": "SUMOylation of RPA1 (RPA70) with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10311307", "map_id": "Q5FW17", "name": "rpa1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000013538", "map_id": "ENSXETG00000013538", "name": "rpa1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328576", "map_id": "Q5FW17", "name": "rpa1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10328649", "map_id": "none", "name": "SUMOylation of Histone H4 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10313794", "map_id": "A0A6I8RKR7", "name": "HIST1H4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10328647", "map_id": "A0A6I8RKR7", "name": "SUMO3-HIST1H4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10328739", "map_id": "none", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328729", "map_id": "F6QFY1", "name": "HDAC2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000023583", "map_id": "ENSXETT00000023583", "name": "SUMO1-K462-HDAC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328737", "map_id": "none", "name": "SUMO1:HDAC2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "F6QFY1", "map_id": "F6QFY1", "name": "SUMO1-K462-HDAC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328659", "map_id": "none", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328657", "map_id": "none", "name": "SUMO1:HIST1H4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10328722", "map_id": "none", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10321877", "map_id": "A0A6I8SGY5", "name": "hdac1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000005253", "map_id": "ENSXETG00000005253", "name": "hdac1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328720", "map_id": "none", "name": "2SUMO1:HDAC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8SGY5", "map_id": "A0A6I8SGY5", "name": "hdac1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328845", "map_id": "none", "name": "PIAS2,3,4 SUMOylate RORA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10317102", "map_id": "A0A6I8QBV8", "name": "rora", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000021123", "map_id": "ENSXETG00000021123", "name": "rora", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328843", "map_id": "none", "name": "SUMO1:RORA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8QBV8", "map_id": "A0A6I8QBV8", "name": "rora", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328832", "map_id": "none", "name": "PIAS2-2,PIAS3,PIAS4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8Q277", "map_id": "A0A6I8Q277", "name": "pias2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S7F8", "map_id": "A0A6I8S7F8", "name": "pias3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328572", "map_id": "none", "name": "PIAS1,3 SUMOylates NR5A1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10317110", "map_id": "F7EHW3", "name": "NR5A1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000025024", "map_id": "ENSXETT00000025024", "name": "NR5A2-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328570", "map_id": "none", "name": "2SUMO1:NR5A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "F7EHW3", "map_id": "F7EHW3", "name": "NR5A2-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328511", "map_id": "none", "name": "PIAS1,2-1 SUMOylates AR with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10317088", "map_id": "A0A6I8RK73", "name": "ar", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10328504", "map_id": "none", "name": "2SUMO1:AR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10328942", "map_id": "none", "name": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328932", "map_id": "none", "name": "NR5A2:cis-bicyclo(3.3.0)oct-2-ene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "CHEBI:77361", "map_id": "CHEBI:77361", "name": "CHEBI:77361", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328940", "map_id": "none", "name": "SUMO1:NR5A2:cis-bicyclo(3.3.0)oct-2-ene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10328536", "map_id": "none", "name": "SUMOylation of NR3C1 (GR) with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328523", "map_id": "none", "name": "NR3C1:(ALDO,11DCORST,CORST,CORT) dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8S149", "map_id": "A0A6I8S149", "name": "nr3c1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040373", "map_id": "ENSXETG00000040373", "name": "nr3c1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328534", "map_id": "none", "name": "2SUMO1:NR3C1:Glucocorticoid ligand dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10328548", "map_id": "none", "name": "PIAS3 SUMOylates PGR with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10317074", "map_id": "F6SI83", "name": "nr3c2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000040897", "map_id": "ENSXETT00000040897", "name": "nr3c2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328546", "map_id": "none", "name": "3SUMO1:PGR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "F6SI83", "map_id": "F6SI83", "name": "nr3c2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328951", "map_id": "none", "name": "SUMOylation of NR1I2 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328944", "map_id": "none", "name": "NR1I2:rifampicin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8RH34", "map_id": "A0A6I8RH34", "name": "nr1i3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031759", "map_id": "ENSXETG00000031759", "name": "nr1i3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28077", "map_id": "CHEBI:28077", "name": "CHEBI:28077", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328949", "map_id": "none", "name": "SUMO3-NR1I2:rifampicin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10328561", "map_id": "none", "name": "PIAS1,3 SUMOylates NR5A1 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10327209", "map_id": "none", "name": "SUMO2:UBE2I", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10328559", "map_id": "F7EHW3", "name": "SUMO2-K119,K194-NR5A1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10328835", "map_id": "none", "name": "PIAS2,3,4 SUMOylate RORA with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328830", "map_id": "A0A6I8QBV8", "name": "rora", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10328495", "map_id": "none", "name": "PIAS1,3 SUMOylate MBD1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328479", "map_id": "A0A6I8RGR4", "name": "mbd1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000040845", "map_id": "ENSXETG00000040845", "name": "mbd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328488", "map_id": "none", "name": "2SUMO1:MBD1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8RGR4", "map_id": "A0A6I8RGR4", "name": "mbd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328219", "map_id": "none", "name": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328201", "map_id": "none", "name": "TRIM28:ZNF350", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8QJW7", "map_id": "A0A6I8QJW7", "name": "trim28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000019245", "map_id": "ENSXETG00000019245", "name": "trim28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RRG3", "map_id": "A0A6I8RRG3", "name": "LOC108647836", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040574", "map_id": "ENSXETG00000040574", "name": "LOC108647836", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RGG7", "map_id": "A0A6I8RGG7", "name": "LOC100493797", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035980", "map_id": "ENSXETG00000035980", "name": "LOC100493797", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328216", "map_id": "none", "name": "SUMO1:TRIM28:ZNF350", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10320733", "map_id": "A0A6I8QJW7", "name": "trim28", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10328336", "map_id": "none", "name": "SUMOylation of DDX5 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328325", "map_id": "F7CZ58", "name": "DDX5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000044525", "map_id": "ENSXETT00000044525", "name": "DDX5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328333", "map_id": "none", "name": "SUMO1:DDX5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "F7CZ58", "map_id": "F7CZ58", "name": "DDX5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337527", "map_id": "none", "name": "Histone acetyltransferases are recruited to the TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10337523", "map_id": "none", "name": "ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q6DEQ4", "map_id": "Q6DEQ4", "name": "gtf2a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000056546", "map_id": "ENSXETT00000056546", "name": "gtf2a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28GG8", "map_id": "Q28GG8", "name": "tbp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000018725", "map_id": "ENSXETT00000018725", "name": "tbp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "L7N2Q7", "map_id": "L7N2Q7", "name": "XB877260", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000009600", "map_id": "ENSXETT00000009600", "name": "XB877260", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8AWH1", "map_id": "Q8AWH1", "name": "foxa1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000025867", "map_id": "ENSXETG00000025867", "name": "foxa1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:142773", "map_id": "CHEBI:142773", "name": "CHEBI:142773", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:27974", "map_id": "CHEBI:27974", "name": "CHEBI:27974", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28F07", "map_id": "Q28F07", "name": "prmt1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000094658", "map_id": "ENSXETT00000094658", "name": "prmt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337509", "map_id": "A0A6I8SAY5", "name": "cited1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000041035", "map_id": "ENSXETG00000041035", "name": "cited1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337525", "map_id": "none", "name": "ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8SAY5", "map_id": "A0A6I8SAY5", "name": "cited1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317879", "map_id": "none", "name": "Parathyroid hormone receptor can bind parathyroid hormone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317875", "map_id": "A0A6I8QXF2", "name": "PTH2(62-100)", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000037389", "map_id": "ENSXETG00000037389", "name": "PTH2(62-100)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317871", "map_id": "none", "name": "Homologues of PTH2R", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q5G7I8", "map_id": "Q5G7I8", "name": "cox1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000000004", "map_id": "ENSXETT00000000004", "name": "cox1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6UDH6", "map_id": "F6UDH6", "name": "LOC100487239", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000022720", "map_id": "ENSXETT00000022720", "name": "LOC100487239", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317877", "map_id": "none", "name": "PTH1R,PTH2R:PTH1R,PTH2R ligands", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8QXF2", "map_id": "A0A6I8QXF2", "name": "PTH2(62-100)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318448", "map_id": "none", "name": "EGF-TM7 receptors bind chondroitin sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_444761", "map_id": "CHEBI:37397", "name": "CHS", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10318444", "map_id": "none", "name": "EGF-7TMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10318446", "map_id": "none", "name": "EGF-7TMs:CHS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10317843", "map_id": "none", "name": "The adrenomedullin receptor can bind adrenomedullin and intermedin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"compartment_display": "none" }, { "id": "CHEBI:16226", "map_id": "CHEBI:16226", "name": "CHEBI:16226", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:27613", "map_id": "CHEBI:27613", "name": "CHEBI:27613", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:5547", "map_id": "CHEBI:5547", "name": "CHEBI:5547", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:2825", "map_id": "CHEBI:2825", "name": "CHEBI:2825", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:73232", "map_id": "CHEBI:73232", "name": "CHEBI:73232", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:18305", "map_id": "CHEBI:18305", "name": "CHEBI:18305", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:3445", "map_id": "CHEBI:3445", "name": "CHEBI:3445", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:36773", "map_id": "CHEBI:36773", "name": "CHEBI:36773", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:2622", "map_id": "CHEBI:2622", "name": "CHEBI:2622", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:73237", "map_id": "CHEBI:73237", "name": "CHEBI:73237", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:2366", "map_id": "CHEBI:2366", "name": "CHEBI:2366", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:3941", "map_id": "CHEBI:3941", "name": "CHEBI:3941", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:7939", "map_id": "CHEBI:7939", "name": "CHEBI:7939", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:351346", "map_id": "CHEBI:351346", "name": "CHEBI:351346", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:8692", "map_id": "CHEBI:8692", "name": "CHEBI:8692", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:73239", "map_id": "CHEBI:73239", "name": "CHEBI:73239", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:15854", "map_id": "CHEBI:15854", "name": "CHEBI:15854", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:9162", "map_id": "CHEBI:9162", "name": "CHEBI:9162", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:26948", "map_id": "CHEBI:26948", "name": "CHEBI:26948", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:50042", "map_id": "CHEBI:50042", "name": "CHEBI:50042", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:69236", "map_id": "CHEBI:69236", "name": "CHEBI:69236", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:73222", "map_id": "CHEBI:73222", "name": "CHEBI:73222", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17698", "map_id": "CHEBI:17698", "name": "CHEBI:17698", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:73236", "map_id": "CHEBI:73236", "name": "CHEBI:73236", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:2853", "map_id": "CHEBI:2853", "name": "CHEBI:2853", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320036", "map_id": "none", "name": "TAS2Rs:Bitter-tasting compounds", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10316852", "map_id": "none", "name": "Metabotropic glutamate receptors bind glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10316848", "map_id": "A0A6I8RDQ8", "name": "grm4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000006732", "map_id": "ENSXETG00000006732", "name": "grm4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10316850", "map_id": "none", "name": "GRM1-8:L-Glu", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8RDQ8", "map_id": "A0A6I8RDQ8", "name": "grm4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317446", "map_id": "none", "name": "DRD1,5 bind DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317442", "map_id": "A0A6I8PSM8", "name": "drd5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000026496", "map_id": "ENSXETG00000026496", "name": "drd5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_380873", "map_id": "CHEBI:18243", "name": "DA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10317444", "map_id": "none", "name": "DRD1,5:DA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PSM8", "map_id": "A0A6I8PSM8", "name": "drd5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317454", "map_id": "none", "name": "HRH2 binds hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317450", "map_id": "A0A6I8Q5E3", "name": "HRH2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000029997", "map_id": "ENSXETG00000029997", "name": "HRH2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317452", "map_id": "none", "name": "HRH2:histamine", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8Q5E3", "map_id": "A0A6I8Q5E3", "name": "HRH2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317462", "map_id": "none", "name": "HRH1 binds hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317458", "map_id": "A0A6I8QYI9", "name": "hrh1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000007717", "map_id": "ENSXETG00000007717", "name": "hrh1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317460", "map_id": "none", "name": "HRH1:Hist", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8QYI9", "map_id": "A0A6I8QYI9", "name": "hrh1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317438", "map_id": "none", "name": "CHRM1,3,5 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317434", "map_id": "none", "name": "CHRM1,3,5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PJ30", "map_id": "A0A6I8PJ30", "name": "chrm5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000017868", "map_id": "ENSXETG00000017868", "name": "chrm5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SRX2", "map_id": "A0A6I8SRX2", "name": "chrm1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037602", "map_id": "ENSXETG00000037602", "name": "chrm1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317436", "map_id": "none", "name": "CHRM1,3,5:AcCho", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10337759", "map_id": "none", "name": "3-agonists bind ADRB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9611836", "map_id": "none", "name": "\u03b23-agonists", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10319102", "map_id": "A0A6I8PZ77", "name": "ADRB3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000030790", "map_id": "ENSXETG00000030790", "name": "ADRB3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337757", "map_id": "none", "name": "\u03b23-agonists:ADBR3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PZ77", "map_id": "A0A6I8PZ77", "name": "ADRB3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317422", "map_id": "none", "name": "ADRA1A,B,D bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317414", "map_id": "none", "name": "ADRA1A,B,D", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F6SBD0", "map_id": "F6SBD0", "name": "adra1d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000037826", "map_id": "ENSXETT00000037826", "name": "adra1d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RMZ6", "map_id": "A0A6I8RMZ6", "name": "adra1a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035197", "map_id": "ENSXETG00000035197", "name": "adra1a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_390627", "map_id": "none", "name": "ADR, NAd", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:28918", "map_id": "CHEBI:28918", "name": "CHEBI:28918", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:18357", "map_id": "CHEBI:18357", "name": "CHEBI:18357", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317416", "map_id": "none", "name": "ADRA1A,B,D:ADR,NAd", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10317420", "map_id": "none", "name": "\u03b11-agonists:ADRA1A,B,D", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10317418", "map_id": "none", "name": "\u03b11-antagonists:ADRA1A,B,D", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10337755", "map_id": "none", "name": "-blockers bind ADRB1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9609307", "map_id": "none", "name": "\u03b2-blockers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10337753", "map_id": "none", "name": "ADRB1,2,3:\u03b2-blockers", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10337761", "map_id": "none", "name": "ADRB3 bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10319104", "map_id": "none", "name": "ADRB3:ADR,NAd", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10317574", "map_id": "none", "name": "Trace amine-associated receptors can bind trace amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317570", "map_id": "none", "name": "Trace amine-associated receptor", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8RAX0", "map_id": "A0A6I8RAX0", "name": "taar1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039183", "map_id": "ENSXETG00000039183", "name": "taar1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_391200", "map_id": "CHEBI:18397", "name": "PEA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10317572", "map_id": "none", "name": "Trace amine-associated receptor:PEA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10317480", "map_id": "none", "name": "HTR1 and 5A receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317476", "map_id": "none", "name": "HTR1B,D,E,F,HTR5A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8R5Z0", "map_id": "A0A6I8R5Z0", "name": "htr1e", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038202", "map_id": "ENSXETG00000038202", "name": "htr1e", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QW91", "map_id": "A0A6I8QW91", "name": "HTR1D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040924", "map_id": "ENSXETG00000040924", "name": "HTR1D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QWR5", "map_id": "A0A6I8QWR5", "name": "htr5a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036447", "map_id": "ENSXETG00000036447", "name": "htr5a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317478", "map_id": "none", "name": "HTR1B,D,E,F,HTR5A:5HT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10317496", "map_id": "none", "name": "5-HT4, 6 and 7 receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317492", "map_id": "A0A6I8PXU4", "name": "HTR7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000031961", "map_id": "ENSXETG00000031961", "name": "HTR7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317494", "map_id": "none", "name": "HTR4,6,7:5HT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PXU4", "map_id": "A0A6I8PXU4", "name": "HTR7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10338203", "map_id": "none", "name": "HTR1A binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10338199", "map_id": "F7CKP0", "name": "htr1b", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000025697", "map_id": "ENSXETT00000025697", "name": "htr1b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10338201", "map_id": "none", "name": "HTR1A:5HT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F7CKP0", "map_id": "F7CKP0", "name": "htr1b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317488", "map_id": "none", "name": "5-HT2 receptor can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317484", "map_id": "F7D3H9", "name": "hrh4.b2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000009523", "map_id": "ENSXETT00000009523", "name": "hrh4.b2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317486", "map_id": "none", "name": "HTR2A-C:5HT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F7D3H9", "map_id": "F7D3H9", "name": "hrh4.b2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334962", "map_id": "none", "name": "GPR143 binds L-Dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10319146", "map_id": "F6TV02", "name": "gpr143", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000044971", "map_id": "ENSXETT00000044971", "name": "gpr143", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8851314", "map_id": "CHEBI:15765", "name": "L-Dopa", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10319148", "map_id": "none", "name": "GPR143:L-Dopa", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F6TV02", "map_id": "F6TV02", "name": "gpr143", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334041", "map_id": "none", "name": "GPR35 binds kynurenic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10334037", "map_id": "A0A6I8PMC3", "name": "GPR35", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000032766", "map_id": "ENSXETG00000032766", "name": "GPR35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6805204", "map_id": "CHEBI:18344", "name": "Kynurenic acid", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10334039", "map_id": "none", "name": "GPR35:Kynurenic acid", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PMC3", "map_id": "A0A6I8PMC3", "name": "GPR35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318999", "map_id": "none", "name": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10318995", "map_id": "A0A6I8Q5A1", "name": "gpr18", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000032224", "map_id": "ENSXETG00000032224", "name": "gpr18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_517533", "map_id": "CHEBI:58961", "name": "NAGLY", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10318997", "map_id": "none", "name": "GPR18:NAGLY", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8Q5A1", "map_id": "A0A6I8Q5A1", "name": "gpr18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318398", "map_id": "none", "name": "FPR is a receptor for formyl peptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10318394", "map_id": "none", "name": "Homologues of FPR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_444519", "map_id": "CHEBI:53490", "name": "FMLP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10318396", "map_id": "none", "name": "FPR1:FMLP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10318384", "map_id": "none", "name": "FPRL2 receptor binds a wide range of ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10318376", "map_id": "none", "name": "Homologues of FPR3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10318380", "map_id": "Q6DJ66", "name": "hebp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETT00000057031", "map_id": "ENSXETT00000057031", "name": "hebp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318382", "map_id": "none", "name": "FPR3:FPR3 ligands", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q6DJ66", "map_id": "Q6DJ66", "name": "hebp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317308", "map_id": "none", "name": "Endothelin receptors bind endothelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317300", "map_id": "A0A6I8QC71", "name": "edn2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000041205", "map_id": "ENSXETG00000041205", "name": "edn2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317304", "map_id": "F6RQM0", "name": "ednrb", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000033726", "map_id": "ENSXETT00000033726", "name": "ednrb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317306", "map_id": "none", "name": "EDNRA,EDNRB:Endothelin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F6RQM0", "map_id": "F6RQM0", "name": "ednrb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QC71", "map_id": "A0A6I8QC71", "name": "edn2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316908", "map_id": "none", "name": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10316886", "map_id": "none", "name": "Homologues of CXCR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10316904", "map_id": "none", "name": "CXCR1 ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10316906", "map_id": "none", "name": "CXCR1:CXCR1 ligands", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10318316", "map_id": "none", "name": "Receptor ACKR2 binds most inflammatory CC chemokines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10318292", "map_id": "F7C531", "name": "rxfp4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000003445", "map_id": "ENSXETT00000003445", "name": "rxfp4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318312", "map_id": "none", "name": "CCBP2 ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8SVN2", "map_id": "A0A6I8SVN2", "name": "LOC101730633", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037100", "map_id": "ENSXETG00000037100", "name": "LOC101730633", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SYD2", "map_id": "A0A6I8SYD2", "name": "CCL11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036196", "map_id": "ENSXETG00000036196", "name": "CCL11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SI97", "map_id": "A0A6I8SI97", "name": "CCL11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318314", "map_id": "none", "name": "ACKR2:CCBP2 ligands", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F7C531", "map_id": "F7C531", "name": "rxfp4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316975", "map_id": "none", "name": "Receptors CXCR4 and 7 bind CXCL12 ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10316967", "map_id": "Q07FZ4", "name": "cxcr4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000032559", "map_id": "ENSXETT00000032559", "name": "cxcr4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10316971", "map_id": "Q5EBF6", "name": "cxcl12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETT00000068483", "map_id": "ENSXETT00000068483", "name": "cxcl12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10316973", "map_id": "none", "name": "CXCR4,7:CXCL12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q5EBF6", "map_id": "Q5EBF6", "name": "cxcl12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q07FZ4", "map_id": "Q07FZ4", "name": "cxcr4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316942", "map_id": "none", "name": "Receptor CXCR2 binds ligands CXCL1 to 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10316938", "map_id": "none", "name": "CXCR2 ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10316910", "map_id": "A0A6I8T2T2", "name": "CXCR2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10316940", "map_id": "none", "name": "CXCR2:CXCR2 ligands", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10316872", "map_id": "none", "name": "CX3CR1 binds CX3CL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10316818", "map_id": "none", "name": "Homologues of CCR3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8R4J8", "map_id": "A0A6I8R4J8", "name": "CCR5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000041335", "map_id": "ENSXETG00000041335", "name": "CCR5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6RFH7", "map_id": "F6RFH7", "name": "ccr7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000046189", "map_id": "ENSXETT00000046189", "name": "ccr7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10316868", "map_id": "none", "name": "Homologues of CX3CL1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10316870", "map_id": "none", "name": "CX3CR1:CX3CL1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10335627", "map_id": "none", "name": "CCR2, CCR3 bind CCL13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10320058", "map_id": "none", "name": "Homologues of CCL13", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10320060", "map_id": "none", "name": "CCR2,CCR3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10320062", "map_id": "none", "name": "CCL13:CCL2,CCR3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10316836", "map_id": "none", "name": "Receptors CCR3, 4 and 5 bind CCL5 ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10316832", "map_id": "none", "name": "CCR3,4,5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10316808", "map_id": "none", "name": "Homologues of CCL5(24-91)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10316834", "map_id": "none", "name": "CCR3,4,5:CCL5(24-91)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10334964", "map_id": "none", "name": "CCR8 binds CCL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10320070", "map_id": "none", "name": "Homologues of CCL1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10316812", "map_id": "A0A6I8R4J8", "name": "CCR3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10320072", "map_id": "none", "name": "CCR8:CCL1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10317326", "map_id": "none", "name": "Neurotensin receptors can bind neurotensins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317316", "map_id": "A0A6I8QBR7", "name": "nts", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000040562", "map_id": "ENSXETG00000040562", "name": "nts", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317320", "map_id": "A0A6I8S4R6", "name": "ntsr2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000037844", "map_id": "ENSXETG00000037844", "name": "ntsr2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317324", "map_id": "none", "name": "NTSR1,NTSR2:NTS(151-163)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8S4R6", "map_id": "A0A6I8S4R6", "name": "ntsr2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QBR7", "map_id": "A0A6I8QBR7", "name": "nts", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317048", "map_id": "none", "name": "Bombesin-like receptors bind bombesin homologues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317040", "map_id": "F7CE29", "name": "grp", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETT00000045737", "map_id": "ENSXETT00000045737", "name": "grp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317044", "map_id": "A0A6I8Q016", "name": "grpr", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000030584", "map_id": "ENSXETG00000030584", "name": "grpr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317046", "map_id": "none", "name": "Bombesin-like receptor:bombesin-like peptide", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8Q016", "map_id": "A0A6I8Q016", "name": "grpr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7CE29", "map_id": "F7CE29", "name": "grp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337771", "map_id": "none", "name": "ARBs bind AGRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10316946", "map_id": "B3DLC0", "name": "agtr1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000023026", "map_id": "ENSXETT00000023026", "name": "agtr1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9615246", "map_id": "none", "name": "ARBs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10316960", "map_id": "none", "name": "ARBs:AGTR1", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "B3DLC0", "map_id": "B3DLC0", "name": "agtr1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318464", "map_id": "none", "name": "Relaxin 3 receptor 1 binds relaxin 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10318452", "map_id": "F7E376", "name": "ltb4r2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000037509", "map_id": "ENSXETT00000037509", "name": "ltb4r2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318460", "map_id": "none", "name": "Relaxin-3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "B1AAQ2", "map_id": "B1AAQ2", "name": "rln3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000062741", "map_id": "ENSXETT00000062741", "name": "rln3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318462", "map_id": "none", "name": "RXFP3:Relaxin-3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F7E376", "map_id": "F7E376", "name": "ltb4r2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318480", "map_id": "none", "name": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10318466", "map_id": "F7E376", "name": "ltb4r2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10318476", "map_id": "none", "name": "RXFP4 ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8SQK1", "map_id": "A0A6I8SQK1", "name": "insl5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036496", "map_id": "ENSXETG00000036496", "name": "insl5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318478", "map_id": "none", "name": "RXFP4:RXFP4 ligands", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10317344", "map_id": "none", "name": "Orexin 2 receptor can bind orexin-B neuropeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317336", "map_id": "A0A6I8RRB4", "name": "hcrt", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000036925", "map_id": "ENSXETG00000036925", "name": "hcrt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317340", "map_id": "F6UHP0", "name": "avpr2.2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000034321", "map_id": "ENSXETT00000034321", "name": "avpr2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317342", "map_id": "none", "name": "HCRTR2:HCRT(70-97)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F6UHP0", "map_id": "F6UHP0", "name": "avpr2.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RRB4", "map_id": "A0A6I8RRB4", "name": "hcrt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316962", "map_id": "none", "name": "AGT(34-41) binds to AGTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10316956", "map_id": "none", "name": "Homologues of AGT(34-41)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q6P614", "map_id": "Q6P614", "name": "serpinf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000057632", "map_id": "ENSXETT00000057632", "name": "serpinf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7BFR9", "map_id": "F7BFR9", "name": "AGT(34-41)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000050417", "map_id": "ENSXETT00000050417", "name": "AGT(34-41)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10316958", "map_id": "none", "name": "AGTR1:AGT(34-41)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10320722", "map_id": "none", "name": "Melanin-concentrating hormone receptors bind MCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10319136", "map_id": "F6YI59", "name": "mchr2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000065305", "map_id": "ENSXETT00000065305", "name": "mchr2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10319140", "map_id": "A0A6I8PX40", "name": "pmch", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000030934", "map_id": "ENSXETG00000030934", "name": "pmch", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10319142", "map_id": "none", "name": "MCHR1,MCHR2:PMCH(147-165)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PX40", "map_id": "A0A6I8PX40", "name": "pmch", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6YI59", "map_id": "F6YI59", "name": "mchr2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317817", "map_id": "none", "name": "S1PR2-5 bind S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_419305", "map_id": "CHEBI:37550", "name": "S1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10317813", "map_id": "none", "name": "S1PR2-5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PRW9", "map_id": "A0A6I8PRW9", "name": "s1pr3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033700", "map_id": "ENSXETG00000033700", "name": "s1pr3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B1WAQ2", "map_id": "B1WAQ2", "name": "s1pr5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000070659", "map_id": "ENSXETT00000070659", "name": "s1pr5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317815", "map_id": "none", "name": "S1PR2-5:S1P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10317803", "map_id": "none", "name": "LPA-binding receptors bind LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317799", "map_id": "A0A6I8RG49", "name": "LPAR5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000039332", "map_id": "ENSXETG00000039332", "name": "LPAR5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_417891", "map_id": "CHEBI:52288", "name": "LPA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10317801", "map_id": "none", "name": "LPAR1,2,3,5:LPA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8RG49", "map_id": "A0A6I8RG49", "name": "LPAR5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318412", "map_id": "none", "name": "HCAR2 binds HCAR2 ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10318408", "map_id": "A0A6I8PVP2", "name": "hcar2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000033184", "map_id": "ENSXETG00000033184", "name": "hcar2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_3296262", "map_id": "none", "name": "HCAR2 ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:20067", "map_id": "CHEBI:20067", "name": "CHEBI:20067", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318410", "map_id": "none", "name": "HCAR2:HCAR2 ligands", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PVP2", "map_id": "A0A6I8PVP2", "name": "hcar2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317756", "map_id": "none", "name": "The UDP/CysLT (P2Y17) receptor can bind UTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317614", "map_id": "A0A6I8Q294", "name": "gpr17", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000030217", "map_id": "ENSXETG00000030217", "name": "gpr17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317754", "map_id": "none", "name": "GPR17:UDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8Q294", "map_id": "A0A6I8Q294", "name": "gpr17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317705", "map_id": "none", "name": "P2Y2 receptor binds ATP and UTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317701", "map_id": "A0A6I8T2N1", "name": "p2ry2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000039207", "map_id": "ENSXETG00000039207", "name": "p2ry2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_511955", "map_id": "none", "name": "ATP,UTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10317703", "map_id": "none", "name": "P2RY2:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8T2N1", "map_id": "A0A6I8T2N1", "name": "p2ry2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317752", "map_id": "none", "name": "A1 and A3 receptors bind adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317746", "map_id": "A0A6I8QZP2", "name": "adora3.1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000031634", "map_id": "ENSXETG00000031634", "name": "adora3.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_83908", "map_id": "CHEBI:16335", "name": "Ade-Rib", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10317750", "map_id": "none", "name": "ADORA1,3:Ade-Rib", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8QZP2", "map_id": "A0A6I8QZP2", "name": "adora3.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327569", "map_id": "none", "name": "HCAR3 binds HCAR3 ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10320048", "map_id": "A0A6I8PVP2", "name": "hcar2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_3296330", "map_id": "none", "name": "HCAR3 ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:37098", "map_id": "CHEBI:37098", "name": "CHEBI:37098", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320050", "map_id": "none", "name": "HCAR3:HCAR3 ligands", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10327571", "map_id": "none", "name": "HCAR1 binds LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10320044", "map_id": "A0A6I8PVP2", "name": "hcar2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10320046", "map_id": "none", "name": "HCAR1:LACT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10327567", "map_id": "none", "name": "GPR31 is a receptor for 12(S)-HETE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10320086", "map_id": "A0A6I8PVP2", "name": "hcar2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_3296298", "map_id": "CHEBI:34146", "name": "12(S)-HETE", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10320088", "map_id": "none", "name": "GPR31:12(S)-HETE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10318324", "map_id": "none", "name": "Receptor FFAR3 binds carboxylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10318320", "map_id": "A0A6I8RL92", "name": "FFAR3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000034865", "map_id": "ENSXETG00000034865", "name": "FFAR3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_444074", "map_id": "none", "name": "FFAR3 ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:31011", "map_id": "CHEBI:31011", "name": "CHEBI:31011", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318322", "map_id": "none", "name": "FFAR3:FFAR3 ligands", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8RL92", "map_id": "A0A6I8RL92", "name": "FFAR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318339", "map_id": "none", "name": "Receptor FFAR2 binds carboxylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_444210", "map_id": "none", "name": "FFAR2 ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:17120", "map_id": "CHEBI:17120", "name": "CHEBI:17120", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318335", "map_id": "A0A6I8RL92", "name": "FFAR2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10318337", "map_id": "none", "name": "FFAR2:FFAR2 ligands", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10327559", "map_id": "none", "name": "SUCNR1 binds SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_433123", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10320040", "map_id": "A0A6I8S407", "name": "SUCNR1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000039349", "map_id": "ENSXETG00000039349", "name": "SUCNR1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320042", "map_id": "none", "name": "SUCNR1:SUCCA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8S407", "map_id": "A0A6I8S407", "name": "SUCNR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318406", "map_id": "none", "name": "Zinc is an agonist of GPR39", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10318402", "map_id": "A0A6I8RPP0", "name": "LOC101732366", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000036628", "map_id": "ENSXETG00000036628", "name": "LOC101732366", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318404", "map_id": "none", "name": "GPR39:Zn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8RPP0", "map_id": "A0A6I8RPP0", "name": "LOC101732366", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318432", "map_id": "none", "name": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10318428", "map_id": "none", "name": "pH sensing receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F7AA76", "map_id": "F7AA76", "name": "gpr68", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000034427", "map_id": "ENSXETT00000034427", "name": "gpr68", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QT77", "map_id": "A0A6I8QT77", "name": "GPR68", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040511", "map_id": "ENSXETG00000040511", "name": "GPR68", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PUB9", "map_id": "A0A6I8PUB9", "name": "gpr4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033328", "map_id": "ENSXETG00000033328", "name": "gpr4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318430", "map_id": "none", "name": "pH sensing receptors:H+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10317644", "map_id": "none", "name": "IP receptor can bind prostacyclin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317640", "map_id": "A0A6I8PVP3", "name": "PTGIR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000031128", "map_id": "ENSXETG00000031128", "name": "PTGIR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_391926", "map_id": "CHEBI:15552", "name": "PGI2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10317642", "map_id": "none", "name": "PTGIR:PGI2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PVP3", "map_id": "A0A6I8PVP3", "name": "PTGIR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317610", "map_id": "none", "name": "DP2 receptor can bind PGD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317606", "map_id": "none", "name": "Homologues of PTGDR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PVU0", "map_id": "A0A6I8PVU0", "name": "PTGDR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035176", "map_id": "ENSXETG00000035176", "name": "PTGDR2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QNA8", "map_id": "A0A6I8QNA8", "name": "LOC101731906", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036987", "map_id": "ENSXETG00000036987", "name": "LOC101731906", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QGG0", "map_id": "A0A6I8QGG0", "name": "PTGDR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_416911", "map_id": "CHEBI:15555", "name": "PGD2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10317608", "map_id": "none", "name": "PTGDR2:PGD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10317697", "map_id": "none", "name": "FP receptor can bind PGF2-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_391928", "map_id": "CHEBI:15553", "name": "PGF2a", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10317693", "map_id": "A0A6I8S7J6", "name": "PTGFR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000036599", "map_id": "ENSXETG00000036599", "name": "PTGFR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317695", "map_id": "none", "name": "PTGFR:PGF2a", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8S7J6", "map_id": "A0A6I8S7J6", "name": "PTGFR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317588", "map_id": "none", "name": "Oxoeicosanoid receptor can bind oxoeicosanoid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317584", "map_id": "A0A6I8PVP2", "name": "hcar2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_416428", "map_id": "CHEBI:52449", "name": "5-oxoETE", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10317586", "map_id": "none", "name": "OXER1:5-oxoETE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10317636", "map_id": "none", "name": "BLT receptors can bind LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317632", "map_id": "none", "name": "LTB4R,LTB4R2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F7B9R6", "map_id": "F7B9R6", "name": "LTB4R2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000038060", "map_id": "ENSXETT00000038060", "name": "LTB4R2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S269", "map_id": "A0A6I8S269", "name": "LTB4R", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036845", "map_id": "ENSXETG00000036845", "name": "LTB4R", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_416436", "map_id": "CHEBI:15647", "name": "LTB4", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10317634", "map_id": "none", "name": "LTB4R,LTB4R2:LTB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10317618", "map_id": "none", "name": "UDP/CysLT receptor can bind cysteinyl leukotrienes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_416372", "map_id": "none", "name": "LTC4,LTD4,LTE4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:28666", "map_id": "CHEBI:28666", "name": "CHEBI:28666", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16978", "map_id": "CHEBI:16978", "name": "CHEBI:16978", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:15650", "map_id": "CHEBI:15650", "name": "CHEBI:15650", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317616", "map_id": "none", "name": "GPR17:Cysteinyl leukotrienes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10317742", "map_id": "none", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10312731", "map_id": "none", "name": "G-protein alpha (13):GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "B1H2U7", "map_id": "B1H2U7", "name": "gna13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000094272", "map_id": "ENSXETT00000094272", "name": "gna13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317739", "map_id": "none", "name": "G-protein alpha (13):GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10317795", "map_id": "none", "name": "GEFs activate RhoA,B,C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10317687", "map_id": "none", "name": "RhoA,B,C:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10316070", "map_id": "none", "name": "GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8QGS5", "map_id": "A0A6I8QGS5", "name": "arhgef17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038787", "map_id": "ENSXETG00000038787", "name": "arhgef17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7DKF6", "map_id": "F7DKF6", "name": "zbtb22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000044021", "map_id": "ENSXETT00000044021", "name": "zbtb22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A4II46", "map_id": "A4II46", "name": "abr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000074782", "map_id": "ENSXETT00000074782", "name": "abr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q734", "map_id": "A0A6I8Q734", "name": "sos2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000009131", "map_id": "ENSXETG00000009131", "name": "sos2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "L7N3Q8", "map_id": "L7N3Q8", "name": "VAV1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000043225", "map_id": "ENSXETT00000043225", "name": "VAV1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312776", "map_id": "none", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane" }, { "id": "species_139827", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_114580", "compartment_display": "platelet dense tubular network lumen", "complex": "false" }, { "id": "species_10312773", "map_id": "none", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane", "complex": "true" }, { "id": "reaction_10317957", "map_id": "none", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76108", "map_id": "CHEBI:29089", "name": "1,2-daG3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10317954", "map_id": "none", "name": "Diacylglycerol kinase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8SXY7", "map_id": "A0A6I8SXY7", "name": "dgkh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000014560", "map_id": "ENSXETG00000014560", "name": "dgkh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SPG5", "map_id": "A0A6I8SPG5", "name": "dgkb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000005053", "map_id": "ENSXETG00000005053", "name": "dgkb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7DCA2", "map_id": "F7DCA2", "name": "dgkd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000006488", "map_id": "ENSXETT00000006488", "name": "dgkd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312816", "map_id": "none", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312771", "map_id": "none", "name": "IP3R tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane", "complex": "true" }, { "id": "reaction_10331377", "map_id": "none", "name": "ABHD6,12 hydrolyse 3AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5694509", "map_id": "CHEBI:75571", "name": "3AG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_422506", "map_id": "CHEBI:15843", "name": "AA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10331374", "map_id": "B4F753", "name": "abhd12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000012789", "map_id": "ENSXETG00000012789", "name": "abhd12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326350", "map_id": "none", "name": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312049", "map_id": "none", "name": "GRB2-1:SOS1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10326342", "map_id": "none", "name": "HB-EGF:p-6Y-EGFR dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8QCY1", "map_id": "A0A6I8QCY1", "name": "hbegf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039798", "map_id": "ENSXETG00000039798", "name": "hbegf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7C8B9", "map_id": "F7C8B9", "name": "phospho-p-4Y-EGFR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000006761", "map_id": "ENSXETT00000006761", "name": "phospho-p-4Y-EGFR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326348", "map_id": "none", "name": "GRB2:SOS1:HB-EGF:p-6Y-EGFR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10326344", "map_id": "none", "name": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10313820", "map_id": "F7C8B9", "name": "EGFR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10313836", "map_id": "A0A6I8QCY1", "name": "hbegf", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10320122", "map_id": "none", "name": "Gastrin binds to CCK-B receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10319126", "map_id": "F6ZEU0", "name": "ghsr", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000050945", "map_id": "ENSXETT00000050945", "name": "ghsr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10319130", "map_id": "F6W277", "name": "gast", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETT00000027311", "map_id": "ENSXETT00000027311", "name": "gast", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10319132", "map_id": "none", "name": "Gastrin:CCKBR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F6W277", "map_id": "F6W277", "name": "gast", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6ZEU0", "map_id": "F6ZEU0", "name": "ghsr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317737", "map_id": "none", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10317734", "map_id": "none", "name": "Phosphodiesterases, cyclic AMP-selective", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F6T8H7", "map_id": "F6T8H7", "name": "pde4d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000040889", "map_id": "ENSXETT00000040889", "name": "pde4d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SHT5", "map_id": "A0A6I8SHT5", "name": "pde4a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000011637", "map_id": "ENSXETG00000011637", "name": "pde4a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10338257", "map_id": "none", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312595", "map_id": "A0A6I8SHT5", "name": "pde4a", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337052", "map_id": "none", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10337050", "map_id": "none", "name": "G alpha (i):GDP:RGS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F7ANT3", "map_id": "F7ANT3", "name": "gsto1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000036860", "map_id": "ENSXETT00000036860", "name": "gsto1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5M8L6", "map_id": "Q5M8L6", "name": "rgs1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000012507", "map_id": "ENSXETT00000012507", "name": "rgs1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RVJ2", "map_id": "A0A6I8RVJ2", "name": "rgs8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035236", "map_id": "ENSXETG00000035236", "name": "rgs8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320096", "map_id": "none", "name": "G-protein alpha (i):GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10337048", "map_id": "none", "name": "RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10312560", "map_id": "none", "name": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312556", "map_id": "B1WAZ6", "name": "phospho-pla2g4a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10312598", "map_id": "none", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10337061", "map_id": "none", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10337056", "map_id": "none", "name": "G alpha (i):GTP:RGS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10337058", "map_id": "none", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10337054", "map_id": "none", "name": "G alpha (i): GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10318153", "map_id": "none", "name": "Aquaporin-4 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10318150", "map_id": "none", "name": "AQP4 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PZD7", "map_id": "A0A6I8PZD7", "name": "aqp4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033655", "map_id": "ENSXETG00000033655", "name": "aqp4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318981", "map_id": "none", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10318974", "map_id": "none", "name": "AQP0,1,2,3,4,5,7,8,9,10,11,12A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8Q4T0", "map_id": "A0A6I8Q4T0", "name": "aqp7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000002150", "map_id": "ENSXETG00000002150", "name": "aqp7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318983", "map_id": "none", "name": "Aquaporins passively transport glycerol out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_192438", "map_id": "CHEBI:17754", "name": "glycerol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10318159", "map_id": "none", "name": "AQP7 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10318977", "map_id": "none", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10318979", "map_id": "none", "name": "Aquaporins passively transport glycerol into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10318162", "map_id": "none", "name": "Aquaporin-7 passively transports glycerol out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10336143", "map_id": "none", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10336130", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "F6TAI6", "map_id": "F6TAI6", "name": "sin3a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000033424", "map_id": "ENSXETT00000033424", "name": "sin3a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0JYW5", "map_id": "B0JYW5", "name": "prmt6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000009939", "map_id": "ENSXETG00000009939", "name": "prmt6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10336140", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10336152", "map_id": "none", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10336147", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10336149", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10336170", "map_id": "none", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10336165", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10336167", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10336161", "map_id": "none", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10336156", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10336158", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10326663", "map_id": "none", "name": "PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10326660", "map_id": "none", "name": "Activator:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F7CWY4", "map_id": "F7CWY4", "name": "LOC101735178", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000011877", "map_id": "ENSXETT00000011877", "name": "LOC101735178", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S7Y3", "map_id": "A0A6I8S7Y3", "name": "phospho-erbb2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000015145", "map_id": "ENSXETG00000015145", "name": "phospho-erbb2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C0IMZ9", "map_id": "C0IMZ9", "name": "phospho-dgcr8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000038110", "map_id": "ENSXETT00000038110", "name": "phospho-dgcr8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SIL3", "map_id": "A0A6I8SIL3", "name": "epgn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031904", "map_id": "ENSXETG00000031904", "name": "epgn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7AYD2", "map_id": "F7AYD2", "name": "XB5893022", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000010416", "map_id": "ENSXETT00000010416", "name": "XB5893022", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316685", "map_id": "none", "name": "Caspase mediated cleavage of vimentin at IDVD (259)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10315647", "map_id": "A0A6I8QV65", "name": "vim", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000007462", "map_id": "ENSXETG00000007462", "name": "vim", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10316674", "map_id": "A0A6I8QV65", "name": "vim", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10316672", "map_id": "A0A6I8QV65", "name": "vim", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10316682", "map_id": "none", "name": "active caspase-8 ", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8Q0P2", "map_id": "A0A6I8Q0P2", "name": "casp8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000032748", "map_id": "ENSXETG00000032748", "name": "casp8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10315899", "map_id": "none", "name": "Caspase mediated cleavage of alpha-II-Fodrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10315893", "map_id": "A0A6I8SVI1", "name": "sptan1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10315895", "map_id": "A0A6I8SVI1", "name": "sptan1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10315897", "map_id": "A0A6I8SVI1", "name": "sptan1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10315654", "map_id": "none", "name": "Caspase-mediated cleavage of vimentin at DSVD (85)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10315651", "map_id": "A0A6I8QV65", "name": "vim", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10315649", "map_id": "A0A6I8QV65", "name": "vim", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10315889", "map_id": "none", "name": "Caspase mediated cleavage of HIP-55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10315883", "map_id": "A0A6I8RKW5", "name": "dbnl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10315887", "map_id": "A0A6I8RKW5", "name": "dbnl", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10315885", "map_id": "A0A6I8RKW5", "name": "dbnl", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10315664", "map_id": "none", "name": "Caspase-mediated cleavage of Tau", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10315658", "map_id": "A0A6I8Q481", "name": "map2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000001624", "map_id": "ENSXETG00000001624", "name": "map2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10315662", "map_id": "A0A6I8Q481", "name": "map2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10315660", "map_id": "A0A6I8Q481", "name": "map2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10322285", "map_id": "none", "name": "Hemoglobin A binds O2, releasing H+ and CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10322281", "map_id": "none", "name": "Protonated Carbamino DeoxyHbA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10322261", "map_id": "none", "name": "OxyHbA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10322216", "map_id": "none", "name": "CA4:Zn2+ dehydrates HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10314265", "map_id": "none", "name": "NF-kB migrates to the nucleus and turns on transcription", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_10318346", "map_id": "none", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_140912", "map_id": "CHEBI:28938", "name": "NH4+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10318343", "map_id": "Q6WRY0", "name": "rhcg", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000017762", "map_id": "ENSXETG00000017762", "name": "rhcg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318353", "map_id": "none", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10318350", "map_id": "Q0IIV2", "name": "rhbg", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000019898", "map_id": "ENSXETG00000019898", "name": "rhbg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318497", "map_id": "none", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10318499", "map_id": "none", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10328233", "map_id": "none", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328125", "map_id": "none", "name": "Acetylated core histone octamer", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10328131", "map_id": "none", "name": "Core histone octamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5566518", "map_id": "CHEBI:30089", "name": "acetate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10328230", "map_id": "A0A6I8QMC7", "name": "hdac10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000031474", "map_id": "ENSXETG00000031474", "name": "hdac10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328226", "map_id": "none", "name": "HDAC8 deacetylates histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328223", "map_id": "B1H369", "name": "hdac8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000044353", "map_id": "ENSXETT00000044353", "name": "hdac8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317294", "map_id": "none", "name": "Glucagon-like Peptide 1 is secreted from intestinal L cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317286", "map_id": "F7D9G8", "name": "gcg", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "ENSXETT00000028848", "map_id": "ENSXETT00000028848", "name": "gcg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317231", "map_id": "F7D9G8", "name": "gcg", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10317292", "map_id": "A0A6I8QCK1", "name": "lep", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000038809", "map_id": "ENSXETG00000038809", "name": "lep", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317907", "map_id": "none", "name": "Proglucagon translocates from the ER Lumen to secretory granules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10317903", "map_id": "F7D9G8", "name": "gcg", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10317905", "map_id": "F7D9G8", "name": "gcg", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "reaction_10317913", "map_id": "none", "name": "ProGIP translocates from the ER Lumen to secretory granules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10317909", "map_id": "A1DPK1", "name": "gip", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "ENSXETT00000062069", "map_id": "ENSXETT00000062069", "name": "gip", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317911", "map_id": "A1DPK1", "name": "gip", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "reaction_10317675", "map_id": "none", "name": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317671", "map_id": "A1DPK1", "name": "gip", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "species_10317673", "map_id": "A1DPK1", "name": "gip", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10313060", "map_id": "none", "name": "Furin cleaves pro-factor IX to factor IX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10313049", "map_id": "Q5M8Y0", "name": "f9", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "ENSXETT00000025939", "map_id": "ENSXETT00000025939", "name": "f9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10313051", "map_id": "Q5M8Y0", "name": "f9", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10313053", "map_id": "Q5M8Y0", "name": "f9", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10313057", "map_id": "A0A6I8RZJ7", "name": "furin", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000015462", "map_id": "ENSXETG00000015462", "name": "furin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334519", "map_id": "none", "name": "Furin cleaves pro-BGLAP to BGLAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10334513", "map_id": "Q6DJ00", "name": "bglap", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "ENSXETT00000005554", "map_id": "ENSXETT00000005554", "name": "bglap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10334515", "map_id": "Q6DJ00", "name": "bglap", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10334517", "map_id": "Q6DJ00", "name": "bglap", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10313171", "map_id": "none", "name": "Furin cleaves pro-protein Z to protein Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10313165", "map_id": "Q5M8Y0", "name": "f9", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10313169", "map_id": "Q5M8Y0", "name": "f9", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10313167", "map_id": "Q5M8Y0", "name": "f9", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10322355", "map_id": "none", "name": "KCNJs transport K+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10322352", "map_id": "none", "name": "KCNJ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q0IJ30", "map_id": "Q0IJ30", "name": "ddx25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000049657", "map_id": "ENSXETT00000049657", "name": "ddx25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10315917", "map_id": "none", "name": "Association of profilin with monomeric actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10315905", "map_id": "none", "name": "G-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6P378", "map_id": "Q6P378", "name": "actg1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000057558", "map_id": "ENSXETT00000057558", "name": "actg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10315913", "map_id": "none", "name": "PFN", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10315915", "map_id": "none", "name": "Profilin:G-actin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10328317", "map_id": "none", "name": "ppDVL binds DAAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10328291", "map_id": "none", "name": "pp-DVL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q05AS8", "map_id": "Q05AS8", "name": "phospho-dvl2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000017212", "map_id": "ENSXETG00000017212", "name": "phospho-dvl2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328313", "map_id": "A0A6I8SJ25", "name": "daam1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000017030", "map_id": "ENSXETG00000017030", "name": "daam1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328315", "map_id": "none", "name": "ppDVL:DAAM1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SJ25", "map_id": "A0A6I8SJ25", "name": "daam1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10330409", "map_id": "none", "name": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10330405", "map_id": "none", "name": "DIAPH3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8RD71", "map_id": "A0A6I8RD71", "name": "diaph3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000018144", "map_id": "ENSXETG00000018144", "name": "diaph3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330399", "map_id": "none", "name": "RHOB:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10330407", "map_id": "none", "name": "RHOB:GTP:DIAPH1,DIAPH3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10329929", "map_id": "none", "name": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10329921", "map_id": "none", "name": "PKN1-3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8R6D3", "map_id": "A0A6I8R6D3", "name": "pkn2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000006092", "map_id": "ENSXETG00000006092", "name": "pkn2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PK39", "map_id": "A0A6I8PK39", "name": "phospho-p-T774-PKN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039434", "map_id": "ENSXETG00000039434", "name": "phospho-p-T774-PKN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10329925", "map_id": "none", "name": "RHOA,RHOB,RHOC,RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10329927", "map_id": "none", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10329945", "map_id": "none", "name": "Phosphorylated PKN1 binds androgen receptor (AR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10329937", "map_id": "A0A6I8PK39", "name": "phospho-p-T774-PKN1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10329941", "map_id": "none", "name": "AR:Androgens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16422", "map_id": "CHEBI:16422", "name": "CHEBI:16422", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:29117", "map_id": "CHEBI:29117", "name": "CHEBI:29117", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10329943", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10329961", "map_id": "none", "name": "PKN1 stimulates association of AR with NCOA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10329957", "map_id": "B5DE09", "name": "ncoa2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000015926", "map_id": "ENSXETG00000015926", "name": "ncoa2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10329951", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10329959", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen:NCOA2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "B5DE09", "map_id": "B5DE09", "name": "ncoa2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329973", "map_id": "none", "name": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10329969", "map_id": "none", "name": "KLK2,3 Gene:Nucleosome with Me3K-10-H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10329971", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10330023", "map_id": "none", "name": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10330008", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10330020", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10329990", "map_id": "none", "name": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10329987", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10329953", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10330047", "map_id": "none", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10330039", "map_id": "none", "name": "RAC1,CDC42:GTP:IQGAPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8S827", "map_id": "A0A6I8S827", "name": "iqgap3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000020384", "map_id": "ENSXETG00000020384", "name": "iqgap3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330043", "map_id": "none", "name": "F-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10330045", "map_id": "none", "name": "RAC1,CDC42:GTP:IQGAP:F-actin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10330041", "map_id": "none", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10330037", "map_id": "none", "name": "IQGAP3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10337088", "map_id": "none", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10337081", "map_id": "none", "name": "Mitochondrial targeting peptides (from inner membrane proteins)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A0A6I8SHX8", "map_id": "A0A6I8SHX8", "name": "ndufb8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000041384", "map_id": "ENSXETG00000041384", "name": "ndufb8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337085", "map_id": "Q28BR5", "name": "pitrm1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "ENSXETG00000009818", "map_id": "ENSXETG00000009818", "name": "pitrm1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329865", "map_id": "none", "name": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane" }, { "id": "species_10329855", "map_id": "none", "name": "SMO dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane", "complex": "true" }, { "id": "A0A6I8RRT2", "map_id": "A0A6I8RRT2", "name": "smo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000014939", "map_id": "ENSXETG00000014939", "name": "smo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10329859", "map_id": "none", "name": "SMO dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "true" }, { "id": "species_10329863", "map_id": "A0A6I8QDD8", "name": "ptch1", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_261122", "compartment_display": "ciliary membrane", "complex": "false" }, { "id": "ENSXETG00000014834", "map_id": "ENSXETG00000014834", "name": "ptch1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329849", "map_id": "none", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10329846", "map_id": "none", "name": "adenylate cyclases:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10330636", "map_id": "none", "name": "CCDC59 binds TTF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10330628", "map_id": "F6XAD1", "name": "ccdc59", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000031815", "map_id": "ENSXETT00000031815", "name": "ccdc59", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330632", "map_id": "A0A6I8R1F2", "name": "ttf1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000040672", "map_id": "ENSXETG00000040672", "name": "ttf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330634", "map_id": "none", "name": "CCDC59:TTF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8R1F2", "map_id": "A0A6I8R1F2", "name": "ttf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6XAD1", "map_id": "F6XAD1", "name": "ccdc59", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10330828", "map_id": "none", "name": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10330816", "map_id": "none", "name": "PALM-C100-CKAP4:SFTPAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8SVN5", "map_id": "A0A6I8SVN5", "name": "sftpa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000009325", "map_id": "ENSXETG00000009325", "name": "sftpa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330826", "map_id": "none", "name": "PALM-C100-CKAP4:SFTPAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_80738", "compartment_display": "lamellar body", "complex": "true" }, { "id": "reaction_10337007", "map_id": "none", "name": "SFTPD binds with itself to form SFTPD 12mer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10337003", "map_id": "none", "name": "SFTPD trimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A6I8R9D1", "map_id": "A0A6I8R9D1", "name": "mbl2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034779", "map_id": "ENSXETG00000034779", "name": "mbl2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337005", "map_id": "none", "name": "SFTPD 12mer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10330798", "map_id": "none", "name": "SFTPAs translocate from ER membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10330794", "map_id": "none", "name": "SFTPA1 18mer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10330796", "map_id": "none", "name": "SFTPA1 18mer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10330830", "map_id": "none", "name": "PALM-C100-CKAP4 binds SFTPAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10330814", "map_id": "F6ULZ5", "name": "PALM-C100-CKAP4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10330809", "map_id": "none", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen" }, { "id": "species_5685882", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "false" }, { "id": "species_10330697", "map_id": "A0A6I8PPP7", "name": "sftpc", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "false" }, { "id": "ENSXETG00000031314", "map_id": "ENSXETG00000031314", "name": "sftpc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330802", "map_id": "A0A6I8PPP7", "name": "sftpc", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "false" }, { "id": "species_10330800", "map_id": "A0A6I8PPP7", "name": "sftpc", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "false" }, { "id": "species_10330806", "map_id": "F6RFS6", "name": "LOC100493461", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "false" }, { "id": "ENSXETT00000003012", "map_id": "ENSXETT00000003012", "name": "LOC100493461", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10331288", "map_id": "none", "name": "CECRI deaminates Ade-Rib to Ino", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_83921", "map_id": "CHEBI:17596", "name": "Ino", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10331285", "map_id": "none", "name": "CECR1:Zn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10330699", "map_id": "none", "name": "pro-SFTPC translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10330695", "map_id": "A0A6I8PPP7", "name": "sftpc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10337812", "map_id": "none", "name": "SFTPD 12mer translocates from ER membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10337810", "map_id": "none", "name": "SFTPD 12mer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10336078", "map_id": "none", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10336068", "map_id": "Q6GL04", "name": "vcp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10336071", "map_id": "Q6GL04", "name": "vcp", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10336075", "map_id": "A0A6I8RIY5", "name": "vcpkmt", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000037439", "map_id": "ENSXETG00000037439", "name": "vcpkmt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336088", "map_id": "none", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312906", "map_id": "A0A6I8SR75", "name": "EEF1A1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10336081", "map_id": "A0A6I8SR75", "name": "Me3K318-EEF1A1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10336085", "map_id": "A0A6I8SWI2", "name": "eef1akmt2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000030721", "map_id": "ENSXETG00000030721", "name": "eef1akmt2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336059", "map_id": "none", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10336052", "map_id": "A0A6I8SR75", "name": "Me3K79-EEF1A1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10336056", "map_id": "A0A6I8Q576", "name": "eef1akmt1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000033485", "map_id": "ENSXETG00000033485", "name": "eef1akmt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10313177", "map_id": "none", "name": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10313175", "map_id": "Q5M8Y0", "name": "f9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10334521", "map_id": "none", "name": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10334511", "map_id": "Q6DJ00", "name": "bglap", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10313066", "map_id": "none", "name": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10313064", "map_id": "Q5M8Y0", "name": "f9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10316020", "map_id": "none", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10316005", "map_id": "A0A6I8QVW9", "name": "eif5a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000034500", "map_id": "ENSXETG00000034500", "name": "eif5a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_204628", "map_id": "CHEBI:15725", "name": "1,3-diaminopropane", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10316009", "map_id": "A0A6I8QVW9", "name": "eif5a", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10316017", "map_id": "none", "name": "DHPS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F6RYK2", "map_id": "F6RYK2", "name": "dhps", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000012343", "map_id": "ENSXETT00000012343", "name": "dhps", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316036", "map_id": "none", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10316025", "map_id": "A0A6I8QVW9", "name": "eif5a", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10316033", "map_id": "none", "name": "DOHH:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SV44", "map_id": "A0A6I8SV44", "name": "dohh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040489", "map_id": "ENSXETG00000040489", "name": "dohh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10338051", "map_id": "none", "name": "TPST1,2 transfer SO4(2-) from PAPS to FVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10338041", "map_id": "A0A6I8SC83", "name": "Factor VIII precursor", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "ENSXETG00000038196", "map_id": "ENSXETG00000038196", "name": "Factor VIII precursor", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10338049", "map_id": "A0A6I8SC83", "name": "OSulf-6Y-FVIII precursor", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10321802", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10321798", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_927893", "compartment_display": "endoplasmic reticulum quality control compartment", "complex": "true" }, { "id": "species_10321800", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:60627", "map_id": "CHEBI:60627", "name": "CHEBI:60627", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:60628", "map_id": "CHEBI:60628", "name": "CHEBI:60628", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:59092", "map_id": "CHEBI:59092", "name": "CHEBI:59092", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:60629", "map_id": "CHEBI:60629", "name": "CHEBI:60629", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:59087", "map_id": "CHEBI:59087", "name": "CHEBI:59087", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335136", "map_id": "none", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8853371", "map_id": "none", "name": "unfolded protein:GlcNAc", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8853381", "map_id": "none", "name": "GlcNAc (Man)9-5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:91280", "map_id": "CHEBI:91280", "name": "CHEBI:91280", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:91284", "map_id": "CHEBI:91284", "name": "CHEBI:91284", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:91283", "map_id": "CHEBI:91283", "name": "CHEBI:91283", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:91282", "map_id": "CHEBI:91282", "name": "CHEBI:91282", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:91281", "map_id": "CHEBI:91281", "name": "CHEBI:91281", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335133", "map_id": "A9JTM7", "name": "otop3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000043623", "map_id": "ENSXETT00000043623", "name": "otop3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328409", "map_id": "none", "name": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_4086285", "map_id": "CHEBI:61248", "name": "Gal-R", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_4086277", "map_id": "CHEBI:75127", "name": "Neu5Ac-2,3-Gal-R", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10328407", "map_id": "none", "name": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_4088006", "map_id": "CHEBI:75133", "name": "Neu5Ac-R", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_4087982", "map_id": "CHEBI:75130", "name": "Neu5Ac-2,8-Neu5Ac-R", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10328404", "map_id": "none", "name": "ST8SIA1-6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "A0A6I8Q045", "map_id": "A0A6I8Q045", "name": "st8sia2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000024127", "map_id": "ENSXETG00000024127", "name": "st8sia2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1KQY5", "map_id": "A1KQY5", "name": "st8sia4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000075006", "map_id": "ENSXETT00000075006", "name": "st8sia4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6DNG6", "map_id": "Q6DNG6", "name": "st8sia1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000023481", "map_id": "ENSXETG00000023481", "name": "st8sia1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QSS5", "map_id": "A0A6I8QSS5", "name": "st8sia3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035254", "map_id": "ENSXETG00000035254", "name": "st8sia3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S6X4", "map_id": "A0A6I8S6X4", "name": "st8sia5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039548", "map_id": "ENSXETG00000039548", "name": "st8sia5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328418", "map_id": "none", "name": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_4088096", "map_id": "none", "name": "Neu5Ac, Neu5Gc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_975925", "map_id": "CHEBI:17012", "name": "Neu5Ac", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "CHEBI:29025", "map_id": "CHEBI:29025", "name": "CHEBI:29025", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_4088099", "map_id": "none", "name": "ManNAc,ManNGc", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:17122", "map_id": "CHEBI:17122", "name": "CHEBI:17122", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28255", "map_id": "CHEBI:28255", "name": "CHEBI:28255", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328415", "map_id": "none", "name": "NPL tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q5M905", "map_id": "Q5M905", "name": "npl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000033244", "map_id": "ENSXETT00000033244", "name": "npl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10333998", "map_id": "none", "name": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6803785", "map_id": "none", "name": "GlcNAc, GlcNGc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:27459", "map_id": "CHEBI:27459", "name": "CHEBI:27459", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6803738", "map_id": "none", "name": "GlcNAc-6-P, GlcNGc-6-P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:15784", "map_id": "CHEBI:15784", "name": "CHEBI:15784", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:88130", "map_id": "CHEBI:88130", "name": "CHEBI:88130", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10333995", "map_id": "none", "name": "NAGK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A5K1VLH5", "map_id": "A0A5K1VLH5", "name": "NAGK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000012241", "map_id": "ENSXETT00000012241", "name": "NAGK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318563", "map_id": "none", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10318560", "map_id": "F6RT68", "name": "LOC101733834", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000029938", "map_id": "ENSXETT00000029938", "name": "LOC101733834", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10319089", "map_id": "none", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_742368", "map_id": "CHEBI:17009", "name": "GDP-Fuc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10319086", "map_id": "A0A6I8SDV6", "name": "slc35c1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000036219", "map_id": "ENSXETG00000036219", "name": "slc35c1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10332336", "map_id": "none", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787678", "map_id": "CHEBI:42589", "name": "beta-Fuc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6787542", "map_id": "CHEBI:12387", "name": "Fuc1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10332333", "map_id": "A0A6I8QCT1", "name": "fcsk", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000040982", "map_id": "ENSXETG00000040982", "name": "fcsk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10320776", "map_id": "none", "name": "Addition of GlcNAc to position 5 by MGAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_981617", "map_id": "none", "name": "Glycoprotein with GlcNAc in position 5", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10320773", "map_id": "A0A6I8QXN5", "name": "mgat5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000000514", "map_id": "ENSXETG00000000514", "name": "mgat5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10321819", "map_id": "none", "name": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_981615", "map_id": "none", "name": "Glycoprotein-Neu5Ac", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10321816", "map_id": "none", "name": "ST8SIA2,3,6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10320769", "map_id": "none", "name": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_981616", "map_id": "none", "name": "Glycoprotein with GlcNAc in position 4", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10320766", "map_id": "A4IID1", "name": "mgat4a", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000019401", "map_id": "ENSXETG00000019401", "name": "mgat4a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10320785", "map_id": "none", "name": "Addition of galactose by beta 4-galactosyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_981618", "map_id": "none", "name": "Glycoprotein with galactose", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10320729", "map_id": "none", "name": "Alternative endo-mannosidase I route", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_964754", "map_id": "CHEBI:59084", "name": "(Glc)3 (GlcNAc)2 (Man)9 (Asn)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_964744", "map_id": "CHEBI:59089", "name": "(GlcNAc)2 (Man)8 (Asn)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_964746", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10320726", "map_id": "A0A6I8RK32", "name": "manea", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "ENSXETG00000038826", "map_id": "ENSXETG00000038826", "name": "manea", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335243", "map_id": "none", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8855720", "map_id": "CHEBI:37396", "name": "proteoglycan", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10335239", "map_id": "none", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10335241", "map_id": "none", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2:proteoglycan", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10335258", "map_id": "none", "name": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10335248", "map_id": "A0A6I8SVT9", "name": "UMOD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "ENSXETG00000037485", "map_id": "ENSXETG00000037485", "name": "Sda-UMOD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335251", "map_id": "A0A6I8SVT9", "name": "Sda-UMOD", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10335149", "map_id": "none", "name": "OTULIN,USP5 cleaves UBB yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10335147", "map_id": "A0A6I8RD22", "name": "ubc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312090", "map_id": "A0A6I8RD22", "name": "ubc", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312094", "map_id": "A0A6I8RD22", "name": "ubc", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312092", "map_id": "A0A6I8RD22", "name": "ubc", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10335142", "map_id": "F6S3V8", "name": "otulin", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000003610", "map_id": "ENSXETT00000003610", "name": "otulin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335145", "map_id": "none", "name": "OTULIN,USP5 cleaves UBC yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10335138", "map_id": "A0A6I8PW00", "name": "UBC", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312114", "map_id": "A0A6I8PW00", "name": "UBC(609-684)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312098", "map_id": "A0A6I8PW00", "name": "UBC(1-76)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312112", "map_id": "A0A6I8PW00", "name": "UBC(533-608)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312102", "map_id": "A0A6I8PW00", "name": "UBC(153-228)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312100", "map_id": "A0A6I8PW00", "name": "UBC(77-152)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312106", "map_id": "A0A6I8PW00", "name": "UBC(305-380)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312104", "map_id": "A0A6I8PW00", "name": "UBC(229-304)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312110", "map_id": "A0A6I8PW00", "name": "UBC(457-532)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312108", "map_id": "A0A6I8PW00", "name": "UBC(381-456)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10313091", "map_id": "none", "name": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10313078", "map_id": "none", "name": "Homologues of N-glycyl-glycosylphosphatidylinositolethanolamine-PLAUR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10313084", "map_id": "none", "name": "Homologues of PLAUR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10313088", "map_id": "A0A6I8Q1P3", "name": "pgap1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000034065", "map_id": "ENSXETG00000034065", "name": "pgap1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10313104", "map_id": "none", "name": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855660", "map_id": "CHEBI:77364", "name": "(ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10313101", "map_id": "none", "name": "PIGF:PIGG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A6I8QRW2", "map_id": "A0A6I8QRW2", "name": "pigg", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000003720", "map_id": "ENSXETG00000003720", "name": "pigg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7ZT49", "map_id": "B7ZT49", "name": "pigf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000055317", "map_id": "ENSXETT00000055317", "name": "pigf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10313123", "map_id": "none", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8855657", "map_id": "CHEBI:15935", "name": "N-acetylglucosaminyl-PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8855661", "map_id": "CHEBI:24275", "name": "glucosaminyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10313120", "map_id": "A0A6I8QB74", "name": "pigl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000038618", "map_id": "ENSXETG00000038618", "name": "pigl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327110", "map_id": "none", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10327093", "map_id": "none", "name": "UBA2:SAE1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q28DS0", "map_id": "Q28DS0", "name": "sae1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000000333", "map_id": "ENSXETT00000000333", "name": "sae1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28GH3", "map_id": "Q28GH3", "name": "uba2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000002374", "map_id": "ENSXETG00000002374", "name": "uba2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10327097", "map_id": "Q6DEP7", "name": "sumo1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10327107", "map_id": "none", "name": "SUMO1:UBA2:SAE1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_164121", "map_id": "CHEBI:16027", "name": "AMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10327143", "map_id": "none", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10327141", "map_id": "A9ULH0", "name": "rwdd3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000025843", "map_id": "ENSXETG00000025843", "name": "rwdd3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325469", "map_id": "none", "name": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10325445", "map_id": "none", "name": "Homologues of AGT(34-43)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10325464", "map_id": "F7EHU5", "name": "ctsg", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10325439", "map_id": "none", "name": "Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10325426", "map_id": "none", "name": "Homologues of AGT(34-42)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10325432", "map_id": "none", "name": "Homologues of AGT(34-40)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10325436", "map_id": "A0A6I8PTH1", "name": "mme", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10325448", "map_id": "none", "name": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323745", "map_id": "F7EHU5", "name": "ctsg", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10325450", "map_id": "none", "name": "Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10337782", "map_id": "none", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9619052", "map_id": "none", "name": "ACEI pro-drugs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_9619021", "map_id": "none", "name": "hydrolysed ACEIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10331304", "map_id": "none", "name": "CES1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10325793", "map_id": "none", "name": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10325790", "map_id": "none", "name": "Carboxypeptidase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8PU97", "map_id": "A0A6I8PU97", "name": "LOC105947369", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033023", "map_id": "ENSXETG00000033023", "name": "LOC105947369", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317212", "map_id": "none", "name": "IGFBP2 binds IGF forming IGF:IGFBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317204", "map_id": "A4IIA2", "name": "igfbp2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETT00000094605", "map_id": "ENSXETT00000094605", "name": "igfbp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317208", "map_id": "F7CZB7", "name": "igf3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETT00000006287", "map_id": "ENSXETT00000006287", "name": "igf3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317210", "map_id": "none", "name": "IGF:IGFBP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "F7CZB7", "map_id": "F7CZB7", "name": "igf3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A4IIA2", "map_id": "A4IIA2", "name": "igfbp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317228", "map_id": "none", "name": "Formation of the IGF:IGFBP5:ALS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10317216", "map_id": "A0A6I8PJ44", "name": "lrrc15", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000006623", "map_id": "ENSXETG00000006623", "name": "lrrc15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317220", "map_id": "Q0IJ34", "name": "igfbp5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETT00000074759", "map_id": "ENSXETT00000074759", "name": "igfbp5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317222", "map_id": "none", "name": "IGF:IGFBP5:ALS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q0IJ34", "map_id": "Q0IJ34", "name": "igfbp5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PJ44", "map_id": "A0A6I8PJ44", "name": "lrrc15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10331191", "map_id": "none", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5691496", "map_id": "none", "name": "NAc-Ser:protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5691517", "map_id": "CHEBI:83690", "name": "NAc-Ser residue", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6785226", "map_id": "CHEBI:36080", "name": "protein", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10331188", "map_id": "F6TFI0", "name": "rpusd3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10330583", "map_id": "none", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5687536", "map_id": "CHEBI:85309", "name": "isoAsp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5687529", "map_id": "CHEBI:31882", "name": "MetAsp", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10330580", "map_id": "A0A6I8PLJ7", "name": "pcmt1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000017500", "map_id": "ENSXETG00000017500", "name": "pcmt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337612", "map_id": "none", "name": "PEX7 binds cargo proteins containing PTS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337604", "map_id": "A0A6I8SMH6", "name": "pex7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000027656", "map_id": "ENSXETG00000027656", "name": "pex7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337608", "map_id": "A0A6I8R668", "name": "agps", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000008462", "map_id": "ENSXETG00000008462", "name": "agps", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337610", "map_id": "none", "name": "PEX7:Cargo proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8R668", "map_id": "A0A6I8R668", "name": "agps", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SMH6", "map_id": "A0A6I8SMH6", "name": "pex7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336877", "map_id": "none", "name": "p-VAV family:PIP3 binds RAC1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10325847", "map_id": "none", "name": "RAC1:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10329285", "map_id": "none", "name": "p-VAV family:PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10329291", "map_id": "none", "name": "p-VAV family:PIP3:RAC1:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10329594", "map_id": "none", "name": "PAK1-3 dimer disassociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10329590", "map_id": "none", "name": "2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10329592", "map_id": "none", "name": "p-VAV family:PIP3:RAC1:GTP:PAK 1-3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10329601", "map_id": "none", "name": "PAK1-3 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10329293", "map_id": "none", "name": "p-VAV family:PIP3:RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10329603", "map_id": "none", "name": "RAC1 binds PAK1-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10329279", "map_id": "none", "name": "PKC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10329272", "map_id": "A8KBH6", "name": "phospho-prkcb", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10329276", "map_id": "A8KBH6", "name": "phospho-prkcb", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10329296", "map_id": "none", "name": "VAV exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10315879", "map_id": "none", "name": "Caspase mediated cleavage of C-IAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10315857", "map_id": "none", "name": "Homologues of BIRC2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SZB7", "map_id": "A0A6I8SZB7", "name": "BIRC2(1-372)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039278", "map_id": "ENSXETG00000039278", "name": "BIRC2(1-372)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SGM4", "map_id": "A0A6I8SGM4", "name": "birc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000022183", "map_id": "ENSXETG00000022183", "name": "birc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QUK4", "map_id": "A0A6I8QUK4", "name": "BIRC2(1-372)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QAZ5", "map_id": "A0A6I8QAZ5", "name": "BIRC2(1-372)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10315877", "map_id": "none", "name": "Homologues of BIRC2(373-618)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10315867", "map_id": "none", "name": "Homologues of BIRC2(1-372)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10315839", "map_id": "none", "name": "Caspase-mediated cleavage of Desmoglein 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10315833", "map_id": "A0A6I8PQG1", "name": "dsg2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10315835", "map_id": "A0A6I8PQG1", "name": "dsg2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10315837", "map_id": "A0A6I8PQG1", "name": "dsg2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10316731", "map_id": "none", "name": "Caspase-mediated cleavage of TJP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10316727", "map_id": "A0A6I8QWP0", "name": "tjp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000020296", "map_id": "ENSXETG00000020296", "name": "tjp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10316729", "map_id": "A0A6I8QWP0", "name": "tjp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10315674", "map_id": "none", "name": "Caspase-mediated cleavage of Desmoglein 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10315668", "map_id": "A0A6I8PQG1", "name": "dsg2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10315670", "map_id": "A0A6I8PQG1", "name": "dsg2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10315672", "map_id": "A0A6I8PQG1", "name": "dsg2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10316723", "map_id": "none", "name": "Caspase-mediated cleavage of Desmoglein 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10316719", "map_id": "A0A6I8PQG1", "name": "dsg2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10316721", "map_id": "A0A6I8PQG1", "name": "dsg2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10334778", "map_id": "none", "name": "PTK6 phosphorylates BCAR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10334769", "map_id": "none", "name": "p-Y342-PTK6:BCAR1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "L7N3R0", "map_id": "L7N3R0", "name": "phospho-p-Y165,Y664-BCAR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000043234", "map_id": "ENSXETT00000043234", "name": "phospho-p-Y165,Y664-BCAR1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q2T5", "map_id": "A0A6I8Q2T5", "name": "ptk6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031017", "map_id": "ENSXETG00000031017", "name": "ptk6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10334775", "map_id": "L7N3R0", "name": "phospho-p-Y165,Y664-BCAR1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10334679", "map_id": "A0A6I8Q2T5", "name": "phospho-ptk6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10334771", "map_id": "none", "name": "PTK6 binds BCAR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10334767", "map_id": "L7N3R0", "name": "BCAR1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10334782", "map_id": "none", "name": "PTK6 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10334780", "map_id": "A0A6I8Q2T5", "name": "phospho-ptk6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10334792", "map_id": "none", "name": "PTK6 phosphorylates KHDRBS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10334786", "map_id": "Q0VFL3", "name": "khdrbs2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000004451", "map_id": "ENSXETG00000004451", "name": "phospho-khdrbs2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10334789", "map_id": "Q0VFL3", "name": "phospho-khdrbs2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10334682", "map_id": "none", "name": "ERBB2 promotes PTK6 autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10334674", "map_id": "none", "name": "p-ERBB2 heterodimers:PTK6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10322318", "map_id": "none", "name": "p-ERBB2 heterodimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10334676", "map_id": "none", "name": "Activated ERBB2 binds PTK6 (BRK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10334672", "map_id": "A0A6I8Q2T5", "name": "ptk6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10334802", "map_id": "none", "name": "SRMS phosphorylates PTK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10334795", "map_id": "A0A6I8Q2T5", "name": "phospho-ptk6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10334799", "map_id": "A0A6I8T1Z7", "name": "srms", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000034490", "map_id": "ENSXETG00000034490", "name": "srms", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318268", "map_id": "none", "name": "ZIP6 and ZIP14 mediate zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10318265", "map_id": "A4IGY6", "name": "slc39a14", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000010532", "map_id": "ENSXETG00000010532", "name": "slc39a14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318288", "map_id": "none", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10318285", "map_id": "A0A6I8R5Y6", "name": "slc39a3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000035832", "map_id": "ENSXETG00000035832", "name": "slc39a3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337769", "map_id": "none", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337767", "map_id": "none", "name": "p-T24,S256,S319-FOXO1:YWHAZ,YWHAQ,YWHAG,YWHAB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q66JJ0", "map_id": "Q66JJ0", "name": "phospho-foxo1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337765", "map_id": "none", "name": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10337071", "map_id": "none", "name": "RUNX2 binds SOX9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10337067", "map_id": "Q6F2E7", "name": "sox9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000087663", "map_id": "ENSXETT00000087663", "name": "sox9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335995", "map_id": "A0A6I8PZM7", "name": "runx2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000001397", "map_id": "ENSXETG00000001397", "name": "runx2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337069", "map_id": "none", "name": "RUNX2:SOX9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q6F2E7", "map_id": "Q6F2E7", "name": "sox9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PZM7", "map_id": "A0A6I8PZM7", "name": "runx2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336222", "map_id": "none", "name": "RMB14 binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10336218", "map_id": "A0A6I8PSM7", "name": "rbm14", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000026650", "map_id": "ENSXETG00000026650", "name": "rbm14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10336220", "map_id": "none", "name": "RUNX2:RBM14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8PSM7", "map_id": "A0A6I8PSM7", "name": "rbm14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336001", "map_id": "none", "name": "Activated AR binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10329949", "map_id": "none", "name": "AR:androgen", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10335999", "map_id": "none", "name": "RUNX2:AR:androgen", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10317275", "map_id": "none", "name": "Formation of NR-NCOR Corepressor Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10317154", "map_id": "none", "name": "NR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A4IIG7", "map_id": "A4IIG7", "name": "nr4a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000011580", "map_id": "ENSXETT00000011580", "name": "nr4a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S377", "map_id": "A0A6I8S377", "name": "nr4a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QVA7", "map_id": "A0A6I8QVA7", "name": "nr2e3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000005219", "map_id": "ENSXETG00000005219", "name": "nr2e3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6V3Y1", "map_id": "F6V3Y1", "name": "pgr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000012055", "map_id": "ENSXETT00000012055", "name": "pgr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7C0K4", "map_id": "F7C0K4", "name": "ppara", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000050646", "map_id": "ENSXETT00000050646", "name": "ppara", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28CK1", "map_id": "Q28CK1", "name": "nr2c1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000023840", "map_id": "ENSXETG00000023840", "name": "nr2c1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QMK1", "map_id": "A0A6I8QMK1", "name": "nrbf2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000007693", "map_id": "ENSXETG00000007693", "name": "nrbf2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6WU58", "map_id": "F6WU58", "name": "nr1i2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000039111", "map_id": "ENSXETT00000039111", "name": "nr1i2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7ETJ5", "map_id": "F7ETJ5", "name": "esrrb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000028937", "map_id": "ENSXETT00000028937", "name": "esrrb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7BMW5", "map_id": "F7BMW5", "name": "ESRRG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000027035", "map_id": "ENSXETT00000027035", "name": "ESRRG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q66JK1", "map_id": "Q66JK1", "name": "nr6a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000090817", "map_id": "ENSXETT00000090817", "name": "nr6a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317271", "map_id": "Q4KKX4", "name": "ncor1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000006720", "map_id": "ENSXETG00000006720", "name": "ncor1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317273", "map_id": "none", "name": "NR-NCOR CoRepressor Complex ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q4KKX4", "map_id": "Q4KKX4", "name": "ncor1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335895", "map_id": "none", "name": "YAP1 binds TEAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10325861", "map_id": "A0A6I8SG09", "name": "tead4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000036112", "map_id": "ENSXETG00000036112", "name": "tead4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335893", "map_id": "none", "name": "TEAD2:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8SG09", "map_id": "A0A6I8SG09", "name": "tead4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10325859", "map_id": "none", "name": "YAP1 binds TEAD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10325855", "map_id": "A0A6I8SG09", "name": "tead4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10325857", "map_id": "none", "name": "TEAD1:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10326415", "map_id": "none", "name": "Dephosphorylated SMAD2/3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10326413", "map_id": "Q07G47", "name": "smad2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000061335", "map_id": "ENSXETT00000061335", "name": "smad2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10323441", "map_id": "Q07G47", "name": "smad2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337276", "map_id": "none", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10337273", "map_id": "none", "name": "RAC1 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10337311", "map_id": "none", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10337308", "map_id": "none", "name": "RAC1 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q08CX6", "map_id": "Q08CX6", "name": "tagap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000056057", "map_id": "ENSXETT00000056057", "name": "tagap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SWA3", "map_id": "A0A6I8SWA3", "name": "sh3bp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000032660", "map_id": "ENSXETG00000032660", "name": "sh3bp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SAF2", "map_id": "A0A6I8SAF2", "name": "ralbp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000004047", "map_id": "ENSXETG00000004047", "name": "ralbp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6UHQ8", "map_id": "F6UHQ8", "name": "ARHGAP31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000010378", "map_id": "ENSXETT00000010378", "name": "ARHGAP31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337349", "map_id": "none", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10337345", "map_id": "F7D6Y2", "name": "arhgdig", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000020510", "map_id": "ENSXETT00000020510", "name": "arhgdig", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337347", "map_id": "none", "name": "RAC1:GDP:RAC1 GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F7D6Y2", "map_id": "F7D6Y2", "name": "arhgdig", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10338163", "map_id": "none", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10330027", "map_id": "none", "name": "RHOA,RHOG,RAC1,CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10330269", "map_id": "none", "name": "KIAA0101 double monoubiquitination", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10330261", "map_id": "Q6AZL2", "name": "pclaf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000057278", "map_id": "ENSXETT00000057278", "name": "pclaf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330267", "map_id": "none", "name": "MonoUb:K15,K24-KIAA0101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q6AZL2", "map_id": "Q6AZL2", "name": "pclaf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312503", "map_id": "none", "name": "Formation of Pol zeta complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10312499", "map_id": "Q28H85", "name": "mad2l2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000102467", "map_id": "ENSXETT00000102467", "name": "mad2l2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312495", "map_id": "A0A6I8PTL2", "name": "rev3l", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000027754", "map_id": "ENSXETG00000027754", "name": "rev3l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312501", "map_id": "none", "name": "POLZ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8PTL2", "map_id": "A0A6I8PTL2", "name": "rev3l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28H85", "map_id": "Q28H85", "name": "mad2l2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326699", "map_id": "none", "name": "LTBP4 binds TGF-Beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10326673", "map_id": "A0A6I8PY10", "name": "ltbp4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000016967", "map_id": "ENSXETG00000016967", "name": "ltbp4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326683", "map_id": "none", "name": "TGF-beta-1:LAP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "F6SX40", "map_id": "F6SX40", "name": "bmp3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000046545", "map_id": "ENSXETT00000046545", "name": "bmp3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326697", "map_id": "none", "name": "LTBP4:TGF-beta-1:LAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8PY10", "map_id": "A0A6I8PY10", "name": "ltbp4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326695", "map_id": "none", "name": "LTBP1, LTBP3 bind TGF-Beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10326691", "map_id": "none", "name": "TGF betas:LAPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10326685", "map_id": "none", "name": "LTBP1, LTBP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8RJM7", "map_id": "A0A6I8RJM7", "name": "ltbp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000019349", "map_id": "ENSXETG00000019349", "name": "ltbp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S6N3", "map_id": "A0A6I8S6N3", "name": "ltbp3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000008431", "map_id": "ENSXETG00000008431", "name": "ltbp3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326693", "map_id": "none", "name": "LTBP1, LTBP3:TGF betas:LAPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10327034", "map_id": "none", "name": "Syndecans 2, (4) bind TGFB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10313442", "map_id": "F6SX40", "name": "bmp3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10325703", "map_id": "A0A6I8R5Q9", "name": "sdc2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10327032", "map_id": "none", "name": "Syndecans 2, (4):TGFB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10326862", "map_id": "none", "name": "DCN (decorin) degradation by MMP2, MMP3, MMP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10326665", "map_id": "A4IIC2", "name": "dcn", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10326858", "map_id": "A4IIC2", "name": "dcn", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10326860", "map_id": "A4IIC2", "name": "dcn", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323712", "map_id": "none", "name": "MMP2,3,4,9,10,12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "F6ZRF9", "map_id": "F6ZRF9", "name": "il17c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000037915", "map_id": "ENSXETT00000037915", "name": "il17c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RGF4", "map_id": "A0A6I8RGF4", "name": "mmp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000002801", "map_id": "ENSXETG00000002801", "name": "mmp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323101", "map_id": "none", "name": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323080", "map_id": "none", "name": "Cleaved collagen fibrils", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q6P4Z2", "map_id": "Q6P4Z2", "name": "col2a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000043834", "map_id": "ENSXETT00000043834", "name": "col2a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R6H3", "map_id": "A0A6I8R6H3", "name": "col4a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000002635", "map_id": "ENSXETG00000002635", "name": "col4a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SI48", "map_id": "A0A6I8SI48", "name": "col4a5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000001565", "map_id": "ENSXETG00000001565", "name": "col4a5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RXV9", "map_id": "A0A6I8RXV9", "name": "col4a6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000001547", "map_id": "ENSXETG00000001547", "name": "col4a6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10323098", "map_id": "none", "name": "MMP1-3, 7-9, 12, 13", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8QL61", "map_id": "A0A6I8QL61", "name": "mmp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000022198", "map_id": "ENSXETG00000022198", "name": "mmp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323166", "map_id": "none", "name": "Collagen type II degradation by MMP1,3,8,13,PRSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323151", "map_id": "none", "name": "Collagen type II fibril", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10322559", "map_id": "none", "name": "Cleaved collagen type II fibril", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10323163", "map_id": "none", "name": "MMP1,3,8,13, PRSS2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10326201", "map_id": "none", "name": "Collagen type XIII ectodomain shedding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10326034", "map_id": "none", "name": "Collagen type XIII", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8SFH9", "map_id": "A0A6I8SFH9", "name": "col19a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037705", "map_id": "ENSXETG00000037705", "name": "col19a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326177", "map_id": "A0A6I8SFH9", "name": "col19a1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10326175", "map_id": "none", "name": "Cleaved collagen type XIII", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10326292", "map_id": "none", "name": "Collagen type XIX degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10326290", "map_id": "none", "name": "Collagen type XIX", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10323715", "map_id": "none", "name": "Collagen type IV degradation by MMP2,3,4,9,10,12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323710", "map_id": "none", "name": "Collagen IV", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10323078", "map_id": "none", "name": "Cleaved collagen type IV networks", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10323113", "map_id": "none", "name": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323109", "map_id": "none", "name": "MMP1, 3, 13, (2, 7-12, 19)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10312984", "map_id": "none", "name": "A2M tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8S564", "map_id": "A0A6I8S564", "name": "ovos2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000009402", "map_id": "ENSXETG00000009402", "name": "ovos2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QI46", "map_id": "A0A6I8QI46", "name": "pzp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000007942", "map_id": "ENSXETG00000007942", "name": "pzp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10323111", "map_id": "none", "name": "Alpha 2-macroglobulin:MMP1, 3, 13, (2, 7-12, 19)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10334763", "map_id": "none", "name": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8848706", "map_id": "none", "name": "substrate protein for calpains", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8848709", "map_id": "none", "name": "calpain-cleaved protein", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10334760", "map_id": "none", "name": "CAPN:4xCa2+:CAPNS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "F7CZN1", "map_id": "F7CZN1", "name": "CAPNS2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000006277", "map_id": "ENSXETT00000006277", "name": "CAPNS2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QL03", "map_id": "A0A6I8QL03", "name": "capn8.3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000030338", "map_id": "ENSXETG00000030338", "name": "capn8.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323839", "map_id": "none", "name": "Initial activation of proMMP13 by plasmin and trypsin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323832", "map_id": "A0A6I8RGF4", "name": "mmp2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323834", "map_id": "A0A6I8RGF4", "name": "mmp2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323836", "map_id": "A0A6I8RGF4", "name": "mmp2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323161", "map_id": "none", "name": "Homologues of PRSS2(24-247)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10323881", "map_id": "none", "name": "Initial activation of proMMP13 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323855", "map_id": "A0A6I8RGF4", "name": "mmp2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323868", "map_id": "A0A6I8RGF4", "name": "mmp2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323878", "map_id": "none", "name": "MMP3, CTSK, CTSL2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8SNY4", "map_id": "A0A6I8SNY4", "name": "ctsk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035558", "map_id": "ENSXETG00000035558", "name": "ctsk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323864", "map_id": "none", "name": "Autocatalytic activation of proMMP13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323853", "map_id": "A0A6I8RGF4", "name": "mmp2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323857", "map_id": "A0A6I8RGF4", "name": "mmp2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323092", "map_id": "A0A6I8RGF4", "name": "mmp2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10323851", "map_id": "none", "name": "Autocatalytic activation of MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323764", "map_id": "F6ZRF9", "name": "il17c", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323848", "map_id": "F6ZRF9", "name": "il17c", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323096", "map_id": "F6ZRF9", "name": "il17c", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10323781", "map_id": "none", "name": "Initial activation of proMMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323762", "map_id": "F6ZRF9", "name": "il17c", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323766", "map_id": "F6ZRF9", "name": "il17c", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323778", "map_id": "none", "name": "proMMP3 initial activators", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8S6I3", "map_id": "A0A6I8S6I3", "name": "klkb1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000005867", "map_id": "ENSXETG00000005867", "name": "klkb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A5G3K998", "map_id": "A0A5G3K998", "name": "ctrb1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000090622", "map_id": "ENSXETT00000090622", "name": "ctrb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323735", "map_id": "none", "name": "Full activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323732", "map_id": "A0A6I8QL61", "name": "mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323084", "map_id": "A0A6I8QL61", "name": "mmp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10323830", "map_id": "none", "name": "Autocatalytic activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323739", "map_id": "A0A6I8QL61", "name": "mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323827", "map_id": "A0A6I8QL61", "name": "mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10323846", "map_id": "none", "name": "Initial activation of proMMP2 by MMP1, 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323841", "map_id": "A0A6I8RGF4", "name": "mmp2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323843", "map_id": "A0A6I8RGF4", "name": "mmp2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323725", "map_id": "A0A6I8RGF4", "name": "mmp2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10323825", "map_id": "none", "name": "Activation of proMMP10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323820", "map_id": "F6ZRF9", "name": "il17c", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323103", "map_id": "F6ZRF9", "name": "il17c", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323822", "map_id": "none", "name": "proMMP10 activators", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10323760", "map_id": "none", "name": "Initial activation of proMMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323737", "map_id": "A0A6I8QL61", "name": "mmp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323741", "map_id": "A0A6I8QL61", "name": "mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323757", "map_id": "none", "name": "proMMP1 initial activators", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10323730", "map_id": "none", "name": "Autocatalytic activation of proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323094", "map_id": "A0A6I8RGF4", "name": "mmp2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10323727", "map_id": "A0A6I8RGF4", "name": "mmp2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10324621", "map_id": "none", "name": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10324614", "map_id": "none", "name": "Lysyl hydroxylases:Lysyl hydroxylase procollagen substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "F7D3M1", "map_id": "F7D3M1", "name": "plod2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000023809", "map_id": "ENSXETT00000023809", "name": "plod2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1650779", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_1650769", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10324618", "map_id": "none", "name": "Lysyl hydroxylases:Lysyl hydroxylated collagen propeptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10324612", "map_id": "none", "name": "PLOD2:Fe2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10336797", "map_id": "none", "name": "Association of procollagen type XXV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10325361", "map_id": "A0A6I8STN5", "name": "col26a1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "ENSXETG00000035357", "map_id": "ENSXETG00000035357", "name": "col26a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10325363", "map_id": "none", "name": "C-linked procollagen type XXV trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "A0A6I8STN5", "map_id": "A0A6I8STN5", "name": "col26a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336799", "map_id": "none", "name": "Association of procollagen type XXVI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10325368", "map_id": "A0A6I8STN5", "name": "col26a1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10325392", "map_id": "none", "name": "C-linked procollagen type XXVI trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10336793", "map_id": "none", "name": "Association of procollagen type XXVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10325394", "map_id": "A0JP88", "name": "col9a2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "ENSXETT00000032928", "map_id": "ENSXETT00000032928", "name": "col9a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10325418", "map_id": "none", "name": "C-linked procollagen type XXVII trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "A0JP88", "map_id": "A0JP88", "name": "col9a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336795", "map_id": "none", "name": "Association of procollagen type XXI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10325329", "map_id": "A0A6I8RDS2", "name": "col22a1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "ENSXETG00000034204", "map_id": "ENSXETG00000034204", "name": "col22a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10325331", "map_id": "none", "name": "C-linked procollagen type XXI trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "A0A6I8RDS2", "map_id": "A0A6I8RDS2", "name": "col22a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336805", "map_id": "none", "name": "Association of procollagen type IV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10325154", "map_id": "none", "name": "Alpha-5(IV) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10325056", "map_id": "A0A6I8RXV9", "name": "col4a6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10325206", "map_id": "A0A6I8RXV9", "name": "col4a6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10325156", "map_id": "A0A6I8RXV9", "name": "col4a6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10325182", "map_id": "A0A6I8SI48", "name": "col4a5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10325054", "map_id": "none", "name": "Alpha-1(IV) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10325232", "map_id": "none", "name": "C-linked procollagen type IV trimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10336791", "map_id": "none", "name": "Association of procollagen type XIV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10325272", "map_id": "A0A6I8RGK2", "name": "col14a1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "ENSXETG00000005761", "map_id": "ENSXETG00000005761", "name": "col14a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10325298", "map_id": "none", "name": "C-linked procollagen type XIV trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "A0A6I8RGK2", "map_id": "A0A6I8RGK2", "name": "col14a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336801", "map_id": "none", "name": "Association of procollagen type XIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10325239", "map_id": "A0A6I8SFH9", "name": "col19a1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10325265", "map_id": "none", "name": "C-linked procollagen type XIII trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10324656", "map_id": "none", "name": "Association of procollagen type XVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10324628", "map_id": "F6VQW0", "name": "col8a1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "ENSXETT00000012721", "map_id": "ENSXETT00000012721", "name": "col8a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10324654", "map_id": "none", "name": "C-linked procollagen type XXVIII trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "F6VQW0", "map_id": "F6VQW0", "name": "col8a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10336803", "map_id": "none", "name": "Association of procollagen type II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10324956", "map_id": "Q6P4Z2", "name": "col2a1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10324980", "map_id": "none", "name": "C-linked procollagen type II trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10336787", "map_id": "none", "name": "Association of procollagen type XXII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10325336", "map_id": "A0A6I8RDS2", "name": "col22a1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10325357", "map_id": "none", "name": "C-linked procollagen type XXII trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10326042", "map_id": "none", "name": "Secretion of transmembrane collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10326008", "map_id": "none", "name": "Transmembrane collagens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10326040", "map_id": "none", "name": "Transmembrane collagens", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10326479", "map_id": "none", "name": "Formation of collagen networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10326477", "map_id": "none", "name": "Tropocollagen type IV", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10326447", "map_id": "none", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323205", "map_id": "none", "name": "Collagen fibrils", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10326445", "map_id": "none", "name": "Collagen fibres", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10326993", "map_id": "none", "name": "Collagen type IV sulfilimine cross-linking by peroxidasin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10326984", "map_id": "none", "name": "Collagen type IV networks with sulfilimine cross-links", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10326990", "map_id": "none", "name": "PXDN:Br-", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A4IGL7", "map_id": "A4IGL7", "name": "pxdn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000006965", "map_id": "ENSXETG00000006965", "name": "pxdn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:15858", "map_id": "CHEBI:15858", "name": "CHEBI:15858", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323207", "map_id": "none", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10323201", "map_id": "none", "name": "Tropocollagens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10326814", "map_id": "none", "name": "Laminins:Nidogens binds collagen type IV networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10326810", "map_id": "none", "name": "Laminins with gamma-1, gamma-3:Nidogens 1,2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8QYL3", "map_id": "A0A6I8QYL3", "name": "lamb1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000012279", "map_id": "ENSXETG00000012279", "name": "lamb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SMI4", "map_id": "A0A6I8SMI4", "name": "lama4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000007336", "map_id": "ENSXETG00000007336", "name": "lama4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0JP86", "map_id": "A0JP86", "name": "lamc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000012525", "map_id": "ENSXETG00000012525", "name": "lamc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RIS5", "map_id": "A0A6I8RIS5", "name": "nid2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000012198", "map_id": "ENSXETG00000012198", "name": "nid2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10326812", "map_id": "none", "name": "Laminins with gamma-1, gamma-3:Nidogens:Collagen type IV network", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10336708", "map_id": "none", "name": "SH3PXD2A binds ADAM12,ADAM15,ADAM19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10336704", "map_id": "A0A6I8PWV8", "name": "adam19", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000034170", "map_id": "ENSXETG00000034170", "name": "adam19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10336700", "map_id": "none", "name": "SH3PXD2A:PI(3,4)P2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8RHF6", "map_id": "A0A6I8RHF6", "name": "sh3pxd2a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000011399", "map_id": "ENSXETG00000011399", "name": "sh3pxd2a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10336706", "map_id": "none", "name": "SH3PXD2A:PI(3,4)P2:ADAM12,ADAM15,ADAM19", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PWV8", "map_id": "A0A6I8PWV8", "name": "adam19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10323437", "map_id": "none", "name": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10323415", "map_id": "none", "name": "CUL3:KLHL12:RBX1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SYH3", "map_id": "A0A6I8SYH3", "name": "klhl12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000025907", "map_id": "ENSXETG00000025907", "name": "klhl12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A4IHP4", "map_id": "A4IHP4", "name": "cul3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000017945", "map_id": "ENSXETT00000017945", "name": "cul3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10323417", "map_id": "none", "name": "DVL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "B1WAP7", "map_id": "B1WAP7", "name": "phospho-dvl3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000037606", "map_id": "ENSXETT00000037606", "name": "phospho-dvl3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10323419", "map_id": "none", "name": "DVL:CUL3:KLHL12:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10323435", "map_id": "none", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10323432", "map_id": "none", "name": "ub-DVL:CUL3:KLHL12:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10328747", "map_id": "none", "name": "DACT1 binds DVL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10328743", "map_id": "Q66KC9", "name": "dact1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000011962", "map_id": "ENSXETG00000011962", "name": "dact1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10315690", "map_id": "Q05AS8", "name": "dvl2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10328745", "map_id": "none", "name": "DVL2:DACT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q66KC9", "map_id": "Q66KC9", "name": "dact1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328777", "map_id": "none", "name": "ZNRF3 autoubiquitinates to promote its internalization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10328767", "map_id": "none", "name": "RSPO:LGR:ZNRF3,RNF43", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q08D68", "map_id": "Q08D68", "name": "znrf3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000070371", "map_id": "ENSXETT00000070371", "name": "znrf3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5M7L6", "map_id": "Q5M7L6", "name": "rspo2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000065307", "map_id": "ENSXETT00000065307", "name": "rspo2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PSP2", "map_id": "A0A6I8PSP2", "name": "rspo1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000030823", "map_id": "ENSXETG00000030823", "name": "rspo1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328774", "map_id": "none", "name": "RSPO:LGR:ub-ZNRF3,RNF43", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10328795", "map_id": "none", "name": "ZNRF3 ubiquitinates FZD to promote its downregulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10328787", "map_id": "none", "name": "N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8QRN7", "map_id": "A0A6I8QRN7", "name": "fzd4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034910", "map_id": "ENSXETG00000034910", "name": "fzd4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S584", "map_id": "A0A6I8S584", "name": "lrp6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000008917", "map_id": "ENSXETG00000008917", "name": "lrp6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328792", "map_id": "none", "name": "N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6:ZNRF3/RNF43", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10328769", "map_id": "none", "name": "RSPO:LGR binds ZNRF3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10328761", "map_id": "none", "name": "RSPO:LGR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10328765", "map_id": "Q08D68", "name": "znrf3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10335855", "map_id": "none", "name": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8869214", "map_id": "CHEBI:52450", "name": "PAF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8869207", "map_id": "CHEBI:91144", "name": "lyso-PAF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10335852", "map_id": "A0A6I8QAQ4", "name": "pafah2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000040379", "map_id": "ENSXETG00000040379", "name": "pafah2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317819", "map_id": "none", "name": "Binding of ATP to P2X receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_114570", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10312780", "map_id": "A0A6I8S619", "name": "LOC100490828", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10312782", "map_id": "none", "name": "P2X purinoreceptors:ATP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10312785", "map_id": "none", "name": "P2X1-mediated entry of Ca++ from plasma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10317725", "map_id": "none", "name": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane" }, { "id": "species_427899", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_114580", "compartment_display": "platelet dense tubular network lumen", "complex": "false" }, { "id": "species_10317722", "map_id": "none", "name": "ATP2A1-3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane", "complex": "true" }, { "id": "A0A6I8Q1N1", "map_id": "A0A6I8Q1N1", "name": "atp2a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000002512", "map_id": "ENSXETG00000002512", "name": "atp2a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RIR9", "map_id": "A0A6I8RIR9", "name": "atp2a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000009695", "map_id": "ENSXETG00000009695", "name": "atp2a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317712", "map_id": "none", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10317709", "map_id": "A0A6I8S1T2", "name": "atp2b2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000000441", "map_id": "ENSXETG00000000441", "name": "atp2b2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328380", "map_id": "none", "name": "EPH receptors autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10328363", "map_id": "none", "name": "EPHA:EFNA oligomers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F6TBR2", "map_id": "F6TBR2", "name": "EFNA4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000007111", "map_id": "ENSXETT00000007111", "name": "EFNA4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SYQ8", "map_id": "A0A6I8SYQ8", "name": "EFNA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039321", "map_id": "ENSXETG00000039321", "name": "EFNA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R3N5", "map_id": "A0A6I8R3N5", "name": "epha7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000018746", "map_id": "ENSXETG00000018746", "name": "epha7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R4R5", "map_id": "A0A6I8R4R5", "name": "epha6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000017584", "map_id": "ENSXETG00000017584", "name": "epha6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328377", "map_id": "none", "name": "p-EPHA:EFNA oligomers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10328388", "map_id": "none", "name": "EPHAs bind EFNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10328359", "map_id": "none", "name": "EPHAs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10328349", "map_id": "none", "name": "EFNAs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10328361", "map_id": "none", "name": "EPHAs:EFNAs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10328519", "map_id": "none", "name": "SDC2 multimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10328515", "map_id": "A0A6I8R5Q9", "name": "phospho-sdc2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10328517", "map_id": "none", "name": "p-Y179,Y191-SDC2 cluster", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10328384", "map_id": "none", "name": "EPH:EFN tetramers oligomerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10328382", "map_id": "none", "name": "EPHA:EFNA dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10328386", "map_id": "none", "name": "EPH:EFN dimers tetramerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10313950", "map_id": "none", "name": "Ubiquitination of stimulated EGFR (CBL:GRB2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10313941", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10313947", "map_id": "none", "name": "EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10313975", "map_id": "none", "name": "Phosphorylation of CBL (EGFR:GRB2:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10313972", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:CBL:GRB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10313968", "map_id": "none", "name": "CBL ubiquitinates Sprouty", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10313961", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8SCT0", "map_id": "A0A6I8SCT0", "name": "phospho-spry1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000041240", "map_id": "ENSXETG00000041240", "name": "phospho-spry1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10313965", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10313903", "map_id": "none", "name": "EGFR autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10313842", "map_id": "none", "name": "EGF-like ligands:EGFR dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10313869", "map_id": "none", "name": "EGF-like ligands:p-6Y EGFR dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10313900", "map_id": "none", "name": "GAB1 phosphorylation by EGFR kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10313892", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:GAB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10313871", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10313886", "map_id": "none", "name": "Dephosphorylation of Gab1 by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10313873", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10313883", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10313913", "map_id": "none", "name": "SHP2 dephosphorylates Tyr 992 on EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10313911", "map_id": "none", "name": "EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10313816", "map_id": "none", "name": "Binding of GRB2 to GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10313812", "map_id": "C0IMZ9", "name": "dgcr8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10313814", "map_id": "none", "name": "GRB2:GAB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10313924", "map_id": "none", "name": "GRB2:GAB1 binds to phosphorylated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10313890", "map_id": "none", "name": "GRB2:GAB1,GRB2:GAB1:PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10313937", "map_id": "none", "name": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10313888", "map_id": "none", "name": "GRB2:GAB1:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10313922", "map_id": "none", "name": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10313919", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10313930", "map_id": "none", "name": "EGFR binds EGF ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10313838", "map_id": "none", "name": "EGF-like ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10313840", "map_id": "none", "name": "EGFR:EGF-like ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10313928", "map_id": "F7BZQ0", "name": "lrig1", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000017426", "map_id": "ENSXETT00000017426", "name": "lrig1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10313844", "map_id": "none", "name": "EGFR dimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10313935", "map_id": "none", "name": "GRB2:SOS1 complex binds to EGF:EGFR complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10313933", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:SOS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10312326", "map_id": "none", "name": "GRB2-1 binds SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312047", "map_id": "F7DKF6", "name": "zbtb22", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10314255", "map_id": "none", "name": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_174602", "map_id": "CHEBI:15904", "name": "LCFAs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_174675", "map_id": "CHEBI:18035", "name": "DAGs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10314252", "map_id": "none", "name": "PNLIPRP2-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10337016", "map_id": "none", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10337013", "map_id": "none", "name": "digestive LIPs", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10314244", "map_id": "none", "name": "Digestion of diacylglycerols by extracellular PTL:colipase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6814795", "map_id": "CHEBI:17408", "name": "MAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10314242", "map_id": "none", "name": "Digestion of triacylglycerols by extracellular PTL:colipase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10329311", "map_id": "none", "name": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10327320", "map_id": "none", "name": "Histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10329304", "map_id": "none", "name": "Me2sR3-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10329308", "map_id": "A0A6I8S695", "name": "prmt7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000006676", "map_id": "ENSXETG00000006676", "name": "prmt7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329214", "map_id": "none", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10329171", "map_id": "none", "name": "MeR12-histone H2A, Histone H2A", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10329211", "map_id": "none", "name": "Me2aR12-histone H2A, MeR12-histone H2A", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10327331", "map_id": "Q28F07", "name": "prmt1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10329098", "map_id": "none", "name": "PRMT6 methylates arginine-4 of histone H2A (H2AR3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10329055", "map_id": "none", "name": "MeR4-histone H2A, Histone H2A", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10329095", "map_id": "none", "name": "Me2aR4-histone H2A, MeR4-histone H2A", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10329010", "map_id": "B0JYW5", "name": "prmt6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10329429", "map_id": "none", "name": "PRMT6 methylates histone H2A arginine-30 (H2AR29)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10329387", "map_id": "none", "name": "MeR30-histone H2A, Histone H2A", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10329427", "map_id": "none", "name": "Me2aR30-histone H2A, MeR30-histone H2A", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10329124", "map_id": "none", "name": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10329112", "map_id": "none", "name": "MeR3-histone H3, Histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10329122", "map_id": "none", "name": "Me2aR3-histone H3, MeR3-histone H3", "type": "inhibitor", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10329015", "map_id": "none", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10329006", "map_id": "A0A6I8RKR7", "name": "MeR4-HIST1H4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10329012", "map_id": "none", "name": "PRMT1,PRMT6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10330343", "map_id": "none", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10330341", "map_id": "A0A6I8RKR7", "name": "Me2aR4-HIST1H4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10329334", "map_id": "none", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10316471", "map_id": "Q6P315", "name": "rbbp7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10329332", "map_id": "none", "name": "RBBP7:Replicative histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10329330", "map_id": "none", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10329326", "map_id": "Q5M786", "name": "wdr5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000102075", "map_id": "ENSXETT00000102075", "name": "wdr5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10329328", "map_id": "none", "name": "WDR5:Me2sR3-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q5M786", "map_id": "Q5M786", "name": "wdr5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10326338", "map_id": "none", "name": "Degradation of ubiquitinated SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10326336", "map_id": "none", "name": "Ub-SMAD2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q07G47", "map_id": "Q07G47", "name": "smad2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337420", "map_id": "none", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10337392", "map_id": "none", "name": "RHOH:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "B1H300", "map_id": "B1H300", "name": "rhoh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000065865", "map_id": "ENSXETT00000065865", "name": "rhoh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337416", "map_id": "none", "name": "RHOH effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SQB3", "map_id": "A0A6I8SQB3", "name": "pak4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000005314", "map_id": "ENSXETG00000005314", "name": "pak4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SBQ3", "map_id": "A0A6I8SBQ3", "name": "csk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000021139", "map_id": "ENSXETG00000021139", "name": "csk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337418", "map_id": "none", "name": "RHOH:GTP:RHOH effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10337396", "map_id": "none", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10337394", "map_id": "none", "name": "RHOH:GTP:RHOH GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10337398", "map_id": "none", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10337390", "map_id": "B1H300", "name": "rhoh", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10319096", "map_id": "none", "name": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_162860", "map_id": "CHEBI:15820", "name": "GDP-Man", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_744239", "map_id": "CHEBI:17345", "name": "guanosine 5'-monophosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_744233", "map_id": "CHEBI:15820", "name": "GDP-Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10312321", "map_id": "none", "name": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179737", "map_id": "none", "name": "ligands of SLC28A3 & 29A1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_179743", "map_id": "none", "name": "ligands of SLC28A3 & 29A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10312318", "map_id": "A0A6I8RH58", "name": "slc28a3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000011724", "map_id": "ENSXETG00000011724", "name": "slc28a3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329473", "map_id": "none", "name": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10329471", "map_id": "none", "name": "ARL2:GTP:ARL2BP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q5FW25", "map_id": "Q5FW25", "name": "arl2bp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000039869", "map_id": "ENSXETT00000039869", "name": "arl2bp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7BJL3", "map_id": "F7BJL3", "name": "arl2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000003496", "map_id": "ENSXETT00000003496", "name": "arl2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10329463", "map_id": "none", "name": "ARL2:GTP:ARL2BP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10329475", "map_id": "none", "name": "ARL2:GTP binds ARL2BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10329467", "map_id": "none", "name": "ARL2:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10329469", "map_id": "Q5FW25", "name": "arl2bp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10316666", "map_id": "none", "name": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10316664", "map_id": "none", "name": "pre-beta HDL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10316576", "map_id": "none", "name": "discoidal HDL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10316578", "map_id": "none", "name": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10313516", "map_id": "A0A6I8PU04", "name": "XB5857568", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10312324", "map_id": "none", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312070", "map_id": "none", "name": "p-Y-IRS1,p-Y-IRS2:PI3K", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10312072", "map_id": "none", "name": "p-Y-IRS1,p-Y-IRS2 bind PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312054", "map_id": "A0A6I8RAF1", "name": "phospho-LOC100498409", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10312058", "map_id": "none", "name": "GRB2-1:SOS1 binds p-IRS1,p-IRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312056", "map_id": "none", "name": "GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10316221", "map_id": "none", "name": "Cleaved fragments of DFF45 dissociate from DFF40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10316198", "map_id": "none", "name": "caspase-3-cleaved DFFA (117,224):DFFB complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "F6TTW7", "map_id": "F6TTW7", "name": "dffa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000013820", "map_id": "ENSXETT00000013820", "name": "dffa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7EHJ0", "map_id": "F7EHJ0", "name": "dffb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000013293", "map_id": "ENSXETT00000013293", "name": "dffb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10316194", "map_id": "F6TTW7", "name": "dffa", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10316196", "map_id": "F6TTW7", "name": "dffa", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10316184", "map_id": "F7EHJ0", "name": "dffb", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10316188", "map_id": "F6TTW7", "name": "dffa", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10316223", "map_id": "none", "name": "Translocation of caspase-3 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10316206", "map_id": "none", "name": "active caspase-3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10316219", "map_id": "none", "name": "Homodimerization of DFF40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10316217", "map_id": "none", "name": "DFF40 homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10316346", "map_id": "none", "name": "Cleavage of DNA by DFF40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10316339", "map_id": "none", "name": "DFF40 associated with chromatin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q6NVM0", "map_id": "Q6NVM0", "name": "h1-0", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000101169", "map_id": "ENSXETT00000101169", "name": "h1-0", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10316337", "map_id": "none", "name": "DFF40 homodimer/homooligomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10316343", "map_id": "none", "name": "DFF cleaved DNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10316341", "map_id": "none", "name": "Association of DFF40 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10316333", "map_id": "none", "name": "Histone H1 bound chromatin DNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10316231", "map_id": "none", "name": "Association of DFF40 with DFF45", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10316227", "map_id": "F7EHJ0", "name": "dffb", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10316225", "map_id": "F6TTW7", "name": "dffa", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10316229", "map_id": "none", "name": "DFFA:DFFB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10316215", "map_id": "none", "name": "Caspase 3-mediated cleavage of DFF45 (117)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10316213", "map_id": "none", "name": "DFFA:DFFB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10316192", "map_id": "none", "name": "Caspase cleaved DFFA (117)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10316209", "map_id": "none", "name": "Cleavage of DFF45 (224) by caspase-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10316073", "map_id": "none", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10316042", "map_id": "none", "name": "RAC1:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10316044", "map_id": "none", "name": "RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10316650", "map_id": "none", "name": "NPC1L1 inactivation by ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10316646", "map_id": "A0A6I8Q9Y0", "name": "npc1l1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000019001", "map_id": "ENSXETG00000019001", "name": "npc1l1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_265479", "map_id": "CHEBI:49040", "name": "EZE", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10316648", "map_id": "none", "name": "NPC1L1:ezetimibe complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8Q9Y0", "map_id": "A0A6I8Q9Y0", "name": "npc1l1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10330543", "map_id": "none", "name": "BIRC2/3 (cIAP1/2) is autoubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10329611", "map_id": "none", "name": "BIRC2,3,4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10330540", "map_id": "none", "name": "K48pUb- BIRC2,3,4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10338143", "map_id": "none", "name": "STUB1 ubiquitinates RIPK3 at K55, K363", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10338134", "map_id": "none", "name": "RIPK3:STUB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8QJD3", "map_id": "A0A6I8QJD3", "name": "LOC100490663", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038971", "map_id": "ENSXETG00000038971", "name": "LOC100490663", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10338140", "map_id": "none", "name": "Ub-K55,363-RIPK3:STUB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10338120", "map_id": "none", "name": "RIPK3 is cleaved by CASP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10338114", "map_id": "A0A6I8QJD3", "name": "LOC100490663", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10338118", "map_id": "A0A6I8QJD3", "name": "LOC100490663", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10338116", "map_id": "A0A6I8QJD3", "name": "LOC100490663", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10338145", "map_id": "none", "name": "RIPK3 binds STUB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10338132", "map_id": "none", "name": "STUB1:STUB1", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10338130", "map_id": "none", "name": "O-GlcNAcylation of RIPK3 (TLR4 signaling)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10338123", "map_id": "A0A6I8QJD3", "name": "LOC100490663", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_110096", "map_id": "CHEBI:17659", "name": "UDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10338127", "map_id": "F6TLZ9", "name": "OGT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000034743", "map_id": "ENSXETT00000034743", "name": "OGT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318991", "map_id": "none", "name": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10318987", "map_id": "F6XC18", "name": "BCL2L1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10318989", "map_id": "none", "name": "Bcl-XL:BH3-only protein complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10312680", "map_id": "none", "name": "Oligomerization of BAK at the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10312676", "map_id": "A0A6I8QFQ5", "name": "BAK1 activated", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10312678", "map_id": "none", "name": "Active oligomeric BAK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10312692", "map_id": "none", "name": "Oligomerization of BAX at the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10312686", "map_id": "F6TEC3", "name": "BAX", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10312690", "map_id": "none", "name": "Activated BAX", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10312688", "map_id": "none", "name": "Translocation of activated BAX to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312684", "map_id": "F6TEC3", "name": "BAX activated", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10312412", "map_id": "none", "name": "Cleavage of uracil by TDG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10312407", "map_id": "none", "name": "TDG:(Ura:Gua)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10312409", "map_id": "none", "name": "TDG:AP-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_29554", "map_id": "CHEBI:17568", "name": "Ura", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10312428", "map_id": "none", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10312423", "map_id": "none", "name": "NTHL1:Tg-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8R4X6", "map_id": "A0A6I8R4X6", "name": "NTHL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035540", "map_id": "ENSXETG00000035540", "name": "NTHL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_110223", "map_id": "CHEBI:29128", "name": "Tg", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10312425", "map_id": "none", "name": "NTHL1:AP-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10312476", "map_id": "none", "name": "Cleavage of ethenocytosine by TDG glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10312473", "map_id": "none", "name": "TDG:EtCYT-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110233", "map_id": "CHEBI:29147", "name": "EtCYT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10312398", "map_id": "none", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10312391", "map_id": "none", "name": "UNG-1:(Ura:Gua)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "F6V364", "map_id": "F6V364", "name": "ung", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000048248", "map_id": "ENSXETT00000048248", "name": "ung", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312395", "map_id": "none", "name": "UNG-1:AP-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10312462", "map_id": "none", "name": "Cleavage of uracil by MBD4 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10312457", "map_id": "none", "name": "MBD4:CpG(U:G)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8PM79", "map_id": "A0A6I8PM79", "name": "mbd4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000026622", "map_id": "ENSXETG00000026622", "name": "mbd4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312459", "map_id": "none", "name": "MBD4:CpG(AP)-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10312442", "map_id": "none", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10312439", "map_id": "none", "name": "NTHL1:DHU-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_30140", "map_id": "CHEBI:15901", "name": "DHU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10312405", "map_id": "none", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10312402", "map_id": "none", "name": "UNG-1:5-OHU-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110216", "map_id": "CHEBI:29115", "name": "5-OHU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10312469", "map_id": "none", "name": "Cleavage of thymine by MBD4 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10312466", "map_id": "none", "name": "MBD4:CpG(T:G)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_29692", "map_id": "CHEBI:17821", "name": "Thy", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10330164", "map_id": "none", "name": "NEIL2 cleaves 5-OHU from damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10330159", "map_id": "none", "name": "NEIL2:5-OHU-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "F7D0D2", "map_id": "F7D0D2", "name": "neil1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000051487", "map_id": "ENSXETT00000051487", "name": "neil1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330161", "map_id": "none", "name": "NEIL2:AP-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10312449", "map_id": "none", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10312446", "map_id": "none", "name": "NTHL1:FapyA-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5637659", "map_id": "CHEBI:27983", "name": "FapyA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10312419", "map_id": "none", "name": "Cleavage of thymine by TDG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10312416", "map_id": "none", "name": "TDG:(T:G)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10312435", "map_id": "none", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10312432", "map_id": "none", "name": "NTHL1:Cg-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110225", "map_id": "CHEBI:29127", "name": "Cg", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10316654", "map_id": "none", "name": "Discoidal HDL binds membrane-associated free cholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10316652", "map_id": "none", "name": "discoidal HDL:cholesterol", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10316660", "map_id": "none", "name": "Spherical HDL binds membrane-associated free cholesterol and phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10316656", "map_id": "none", "name": "spherical HDL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10316658", "map_id": "none", "name": "enlarged spherical HDL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10331331", "map_id": "none", "name": "LIPC dimer hydrolyses TAG to DAG and FA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_422024", "map_id": "CHEBI:35366", "name": "FAs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10331328", "map_id": "none", "name": "LIPC dimer:heparin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10332258", "map_id": "none", "name": "LIPC dimer binds heparin", "reversible": "false", "notes": "", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10331326", "map_id": "none", "name": "LIPC dimer", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10313538", "map_id": "none", "name": "chylomicron remnant + apoE => chylomicron remnant:apoE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10313530", "map_id": "Q6P615", "name": "apoe", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETT00000100802", "map_id": "ENSXETT00000100802", "name": "apoe", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10313532", "map_id": "none", "name": "chylomicron remnant", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q6P615", "map_id": "Q6P615", "name": "apoe", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10313534", "map_id": "none", "name": "chylomicron remnant:apoE complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10317772", "map_id": "none", "name": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_204883", "compartment_display": "cell junction" }, { "id": "species_140648", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10317768", "map_id": "none", "name": "Classic Cadherin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8SWY9", "map_id": "A0A6I8SWY9", "name": "cdh15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000011269", "map_id": "ENSXETG00000011269", "name": "cdh15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RR45", "map_id": "A0A6I8RR45", "name": "cdh9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000020131", "map_id": "ENSXETG00000020131", "name": "cdh9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6XNI3", "map_id": "F6XNI3", "name": "VE-cadherin", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000034059", "map_id": "ENSXETT00000034059", "name": "VE-cadherin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317770", "map_id": "none", "name": "Cadherin trans-homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_204883", "compartment_display": "cell junction", "complex": "true" }, { "id": "reaction_10318171", "map_id": "none", "name": "Cis-homodimerization of nectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10317776", "map_id": "F7E015", "name": "nectin3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000020211", "map_id": "ENSXETT00000020211", "name": "nectin3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317778", "map_id": "none", "name": "Nectin cis-homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F7E015", "map_id": "F7E015", "name": "nectin3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317893", "map_id": "none", "name": "PVR:PVRL3 trans heterodimer interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_204883", "compartment_display": "cell junction" }, { "id": "species_10314618", "map_id": "A0A6I8QUW8", "name": "PVR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000038811", "map_id": "ENSXETG00000038811", "name": "PVR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317891", "map_id": "none", "name": "PRV:PVRL3 trans heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_204883", "compartment_display": "cell junction", "complex": "true" }, { "id": "A0A6I8QUW8", "map_id": "A0A6I8QUW8", "name": "PVR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317782", "map_id": "none", "name": "Transhomodimerization of Nectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_204883", "compartment_display": "cell junction" }, { "id": "species_10317780", "map_id": "none", "name": "Nectin trans homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_204883", "compartment_display": "cell junction", "complex": "true" }, { "id": "reaction_10331249", "map_id": "none", "name": "ANG binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10331241", "map_id": "none", "name": "F-actin", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10331245", "map_id": "A0A6I8R6T7", "name": "ANG", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10331247", "map_id": "none", "name": "F-actin:ANG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10317889", "map_id": "none", "name": "Transhomodimerization of Nectin-like (Necl) proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_204883", "compartment_display": "cell junction" }, { "id": "species_10317885", "map_id": "none", "name": "Necl-3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q6DJ83", "map_id": "Q6DJ83", "name": "cadm2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000026489", "map_id": "ENSXETG00000026489", "name": "cadm2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317887", "map_id": "none", "name": "Necl-1/Necl-2/Necl-3 trans homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_204883", "compartment_display": "cell junction", "complex": "true" }, { "id": "reaction_10337532", "map_id": "none", "name": "AGO2 cleaves passenger strand of duplex siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10325973", "map_id": "none", "name": "AGO2:duplex siRNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6DJB9", "map_id": "Q6DJB9", "name": "ago2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000051244", "map_id": "ENSXETT00000051244", "name": "ago2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337529", "map_id": "none", "name": "AGO2:cleaved duplex siRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10317966", "map_id": "none", "name": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_426463", "map_id": "none", "name": "Double-stranded RNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10315976", "map_id": "none", "name": "TARBP2,PRKRA RLC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "B3DLA6", "map_id": "B3DLA6", "name": "dicer1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000096069", "map_id": "ENSXETT00000096069", "name": "dicer1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5BJ52", "map_id": "Q5BJ52", "name": "tarbp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000012644", "map_id": "ENSXETG00000012644", "name": "tarbp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S266", "map_id": "A0A6I8S266", "name": "prkra", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036175", "map_id": "ENSXETG00000036175", "name": "prkra", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317963", "map_id": "none", "name": "TARBP2,PRKRA RLC:duplex siRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10325989", "map_id": "none", "name": "Duplex siRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10325979", "map_id": "none", "name": "TARBP2,PRKRA:DICER1:Pre-RISC (siRNA)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10325987", "map_id": "none", "name": "Removal of siRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10325985", "map_id": "none", "name": "TARBP2,PRKRA:DICER1:RISC (siRNA)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10317981", "map_id": "none", "name": "Endonucleolytic RISC hydrolyzes target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_426523", "map_id": "none", "name": "RNA (exact match)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_426511", "map_id": "none", "name": "Cleaved RNA with 5' Phosphate and 3' Hydroxyl", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10317970", "map_id": "none", "name": "Endonucleolytic RISC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10317978", "map_id": "none", "name": "RISC binds inexactly matching target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10317974", "map_id": "A0A6I8RHW3", "name": "tnrc6a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000030437", "map_id": "ENSXETG00000030437", "name": "tnrc6a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_426515", "map_id": "none", "name": "RNA (inexact match)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10317976", "map_id": "none", "name": "TNRC6:RISC:Target RNA (inexact match)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8RHW3", "map_id": "A0A6I8RHW3", "name": "tnrc6a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10316176", "map_id": "none", "name": "Removal of miRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10316164", "map_id": "none", "name": "TARBP2,PRKRA:DICER1:Pre-RISC (miRNA)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10316174", "map_id": "none", "name": "TARBP2,PRKRA:DICER1:RISC (miRNA)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10325971", "map_id": "none", "name": "Duplex miRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10325969", "map_id": "none", "name": "TARBP2,PRKRA RLC:duplex miRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10329786", "map_id": "none", "name": "TNRC6A:AGO2:miRNA is transported into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10329778", "map_id": "none", "name": "TNRC6A:AGO2:miRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10329784", "map_id": "none", "name": "TNRC6A:AGO2:miRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10329780", "map_id": "none", "name": "TNRC6A binds AGO2:miRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10316168", "map_id": "none", "name": "AGO2:miRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10316485", "map_id": "none", "name": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10316481", "map_id": "none", "name": "PRC2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8QJB3", "map_id": "A0A6I8QJB3", "name": "phf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000020362", "map_id": "ENSXETG00000020362", "name": "phf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10316457", "map_id": "none", "name": "Chromatin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10316483", "map_id": "none", "name": "PRC2:Chromatin", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10316517", "map_id": "none", "name": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10316508", "map_id": "none", "name": "DNMT1,3A,3B:PRC2:Chromatin", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10316514", "map_id": "none", "name": "DNMT1,3A,3B:PRC2:Chromatin (5-mC, H3K27me3)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10316502", "map_id": "none", "name": "PRC2 trimethylates histone H3 at lysine-27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10316499", "map_id": "none", "name": "PRC2:Chromatin (H3K27me3)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10329316", "map_id": "none", "name": "TDG excises 5-carboxylcytosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5220996", "map_id": "none", "name": "DNA containing 5-caC", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_5221064", "map_id": "CHEBI:76793", "name": "5-caC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10329314", "map_id": "none", "name": "TDG excises 5-formylcytosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5221062", "map_id": "none", "name": "DNA containing 5-fC", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_5221065", "map_id": "CHEBI:76794", "name": "5-fC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10330834", "map_id": "none", "name": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312336", "map_id": "none", "name": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10312334", "map_id": "none", "name": "GRB2-1:p-4S-SOS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10312039", "map_id": "none", "name": "Re-integration of insulin receptor into plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10312037", "map_id": "none", "name": "insulin receptor", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "A0A6I8QUB9", "map_id": "A0A6I8QUB9", "name": "insr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000013518", "map_id": "ENSXETG00000013518", "name": "insr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312021", "map_id": "none", "name": "Insulin receptor", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10322416", "map_id": "none", "name": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10322413", "map_id": "none", "name": "EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10322418", "map_id": "none", "name": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10322409", "map_id": "none", "name": "EGF:p-EGFR:p-ERBB2:GRB2:GAB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10324487", "map_id": "none", "name": "MATK (CSK homologous kinase) binds phosphorylated ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10324483", "map_id": "A0A6I8RYR6", "name": "matk", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000032315", "map_id": "ENSXETG00000032315", "name": "matk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10324485", "map_id": "none", "name": "p-ERBB2 heterodimers:MATK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8RYR6", "map_id": "A0A6I8RYR6", "name": "matk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335698", "map_id": "none", "name": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10335683", "map_id": "none", "name": "Phosphorylated ERBB2:EGFR heterodimers:PTPN18", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10335695", "map_id": "none", "name": "Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers:PTPN18", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10324503", "map_id": "none", "name": "Trans-autophosphorylation of ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10324500", "map_id": "none", "name": "EGF:EGFR:ERBB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10322311", "map_id": "none", "name": "EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10322327", "map_id": "none", "name": "SHC1 phosphorylation by ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10322320", "map_id": "none", "name": "SHC1:Phosphorylated ERBB2 heterodimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10322324", "map_id": "none", "name": "p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10332266", "map_id": "none", "name": "Phosphorylated ERBB2 heterodimers bind MEMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10332262", "map_id": "Q6DJ03", "name": "memo1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETT00000018710", "map_id": "ENSXETT00000018710", "name": "memo1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10332264", "map_id": "none", "name": "p-ERBB2 heterodimers:MEMO1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q6DJ03", "map_id": "Q6DJ03", "name": "memo1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10324496", "map_id": "none", "name": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10324493", "map_id": "none", "name": "EGF:EGFR:p-Y877-ERBB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10322316", "map_id": "none", "name": "EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10322488", "map_id": "none", "name": "Activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10317330", "map_id": "none", "name": "RAC1:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10322485", "map_id": "none", "name": "p-VAV1:PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10312285", "map_id": "none", "name": "Membrane-anchored TNF-alpha binds TNFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10312281", "map_id": "none", "name": "TNFRSF1A:BAG4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F6X123", "map_id": "F6X123", "name": "cyp2a6.7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000023023", "map_id": "ENSXETT00000023023", "name": "cyp2a6.7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312271", "map_id": "none", "name": "TNF(1-233) trimer", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10312279", "map_id": "F6X123", "name": "cyp2a6.7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10312283", "map_id": "none", "name": "TNF-alpha:TNFR1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10327781", "map_id": "none", "name": "Soluble TNF-alpha binds TNFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10327777", "map_id": "none", "name": "TNF-alpha trimer, soluble form", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10327779", "map_id": "none", "name": "soluble TNF-alpha:TNFR1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10337807", "map_id": "none", "name": "MMPs cleave HB-EGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10337798", "map_id": "A0A6I8QCY1", "name": "hbegf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10337800", "map_id": "A0A6I8QCY1", "name": "hbegf", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10337802", "map_id": "none", "name": "MMP2,3,7,9", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10337805", "map_id": "none", "name": "S1P:S1PR3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10337899", "map_id": "none", "name": "p-S10 CDKN1B translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10337895", "map_id": "A0A6I8SFF7", "name": "phospho-p-S10 CDKN1B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10337897", "map_id": "A0A6I8SFF7", "name": "phospho-p-S10 CDKN1B", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337824", "map_id": "none", "name": "S1P binds S1PR3 in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5218688", "map_id": "CHEBI:37550", "name": "S1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10317807", "map_id": "A0A6I8PRW9", "name": "s1pr3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10313536", "map_id": "none", "name": "Degradation of newly synthesized ApoB-48", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10313490", "map_id": "A0A6I8RKY6", "name": "apob", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10335790", "map_id": "none", "name": "VLDL translocates from SER lumen to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_10335778", "map_id": "none", "name": "VLDL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum", "complex": "true" }, { "id": "species_10335788", "map_id": "none", "name": "VLDL (-APOC1,C4)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10335786", "map_id": "none", "name": "pre-VLDL translocates from RER membrane to SER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_10335784", "map_id": "none", "name": "pre-VLDL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10335776", "map_id": "none", "name": "pre-VLDL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum", "complex": "true" }, { "id": "reaction_10335780", "map_id": "none", "name": "pre-VLDL binds lipids to form VLDL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8866316", "map_id": "CHEBI:17002", "name": "CHEST", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum", "complex": "false" }, { "id": "species_8866305", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum", "complex": "false" }, { "id": "species_8866307", "map_id": "CHEBI:17855", "name": "TAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum", "complex": "false" }, { "id": "species_8866324", "map_id": "CHEBI:16247", "name": "PL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum", "complex": "false" }, { "id": "reaction_10330351", "map_id": "none", "name": "MT1A binds zinc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10330347", "map_id": "A0A6I8RW79", "name": "mt4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000030675", "map_id": "ENSXETG00000030675", "name": "mt4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330349", "map_id": "none", "name": "MT1A:7Zn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8RW79", "map_id": "A0A6I8RW79", "name": "mt4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10330383", "map_id": "none", "name": "MT3 binds cadmium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1132098", "map_id": "CHEBI:48775", "name": "Cd2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10330367", "map_id": "A0A6I8RW79", "name": "mt4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10330381", "map_id": "none", "name": "MT3:7Cd2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10330379", "map_id": "none", "name": "MT3 exchanges zinc for copper", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10330369", "map_id": "none", "name": "MT3:7Zn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10330377", "map_id": "none", "name": "MT3:4Zn2+:4Cu+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_3299744", "map_id": "CHEBI:49552", "name": "Cu1+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10330375", "map_id": "none", "name": "MT2A binds cadmium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10330373", "map_id": "none", "name": "MT2A:7Cd2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10330355", "map_id": "none", "name": "MT1A binds arsenic", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5661216", "map_id": "CHEBI:35828", "name": "As3+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10330353", "map_id": "none", "name": "MT1A:6As3+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10330387", "map_id": "none", "name": "MT2A binds copper", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10330385", "map_id": "none", "name": "MT2A:10Cu1+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10330371", "map_id": "none", "name": "MT3 binds zinc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10330863", "map_id": "none", "name": "MAPK4,6 translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10330857", "map_id": "none", "name": "MAPK4,6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8RH21", "map_id": "A0A6I8RH21", "name": "mapk4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038723", "map_id": "ENSXETG00000038723", "name": "mapk4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330861", "map_id": "none", "name": "MAPK4,6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10330849", "map_id": "none", "name": "PAK1,2,3 phosphorylates MAPK6,4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10330843", "map_id": "A0A6I8RH21", "name": "mapk4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10330846", "map_id": "A0A6I8RH21", "name": "phospho-mapk4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10338027", "map_id": "none", "name": "USP17L2 deubiquitinates RCE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10338022", "map_id": "B7ZT68", "name": "rce1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10338024", "map_id": "B7ZT68", "name": "rce1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10331547", "map_id": "F7BNK9", "name": "emp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10338001", "map_id": "none", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9647934", "map_id": "none", "name": "Palmostatin B", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10337997", "map_id": "none", "name": "LYPLA1 dimer, ABHD17A,B,C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6GL10", "map_id": "Q6GL10", "name": "abhd17c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000004138", "map_id": "ENSXETT00000004138", "name": "abhd17c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6DEY3", "map_id": "Q6DEY3", "name": "abhd17b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000057305", "map_id": "ENSXETT00000057305", "name": "abhd17b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337999", "map_id": "none", "name": "Palmostatin B:LYPLA1 dimer, ABHD17A,B,C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10330310", "map_id": "none", "name": "SPRED dimer binds NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10330297", "map_id": "none", "name": "SPRED dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q66JG9", "map_id": "Q66JG9", "name": "spred1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000039156", "map_id": "ENSXETT00000039156", "name": "spred1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330301", "map_id": "A0A6I8R7X8", "name": "nf1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000021350", "map_id": "ENSXETG00000021350", "name": "nf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330303", "map_id": "none", "name": "SPRED dimer:NF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8R7X8", "map_id": "A0A6I8R7X8", "name": "nf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337357", "map_id": "none", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312723", "map_id": "none", "name": "RAC2:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F7DEH8", "map_id": "F7DEH8", "name": "RAC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000009928", "map_id": "ENSXETT00000009928", "name": "RAC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337353", "map_id": "none", "name": "RAC2 plasma membrane effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8S090", "map_id": "A0A6I8S090", "name": "garre1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000032218", "map_id": "ENSXETG00000032218", "name": "garre1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337355", "map_id": "none", "name": "RAC2:GTP:RAC2 cytosolic effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10337369", "map_id": "none", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10330417", "map_id": "none", "name": "RAC2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10338297", "map_id": "none", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10338295", "map_id": "none", "name": "RAC2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10337367", "map_id": "none", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337351", "map_id": "none", "name": "RAC2:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10337364", "map_id": "none", "name": "RAC2 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10338289", "map_id": "none", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10338279", "map_id": "none", "name": "RAC2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10338285", "map_id": "none", "name": "RAC2 mitochondrial effectors", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10338287", "map_id": "none", "name": "RAC2:GTP:RAC2 mitochondrial effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10338291", "map_id": "none", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10337362", "map_id": "none", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337359", "map_id": "none", "name": "RAC2 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8QIL4", "map_id": "A0A6I8QIL4", "name": "arhgap1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000001985", "map_id": "ENSXETG00000001985", "name": "arhgap1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B5DFQ4", "map_id": "B5DFQ4", "name": "arhgap26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000003971", "map_id": "ENSXETT00000003971", "name": "arhgap26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311975", "map_id": "none", "name": "FAS-mediated dimerization of procaspase-8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10311969", "map_id": "none", "name": "FASL:FAS trimer:FADD:CASP8(1-479)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8PTW1", "map_id": "A0A6I8PTW1", "name": "fas", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031916", "map_id": "ENSXETG00000031916", "name": "fas", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QWZ8", "map_id": "A0A6I8QWZ8", "name": "faslg", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000041356", "map_id": "ENSXETG00000041356", "name": "faslg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10311967", "map_id": "A0A6I8Q0P2", "name": "casp8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10311973", "map_id": "none", "name": "FASL:FAS receptor trimer:FADD:procaspase-8-dimer ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10338303", "map_id": "none", "name": "RAC3 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10337426", "map_id": "none", "name": "RAC3:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10338301", "map_id": "none", "name": "RAC3:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10337431", "map_id": "none", "name": "RAC3 GAPs stimulate RAC3 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10337424", "map_id": "none", "name": "RAC3:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10337428", "map_id": "none", "name": "RAC3 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10337441", "map_id": "none", "name": "RAC3 GDIs block activation of RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10337433", "map_id": "none", "name": "RAC3 GDIs", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10337439", "map_id": "none", "name": "RAC3:GDP:RAC3 GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10337386", "map_id": "none", "name": "RHOQ GAPs stimulate RHOQ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337379", "map_id": "none", "name": "RHOQ:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F6ZQ78", "map_id": "F6ZQ78", "name": "RHOQ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000010273", "map_id": "ENSXETT00000010273", "name": "RHOQ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337381", "map_id": "none", "name": "RHOQ:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10337383", "map_id": "none", "name": "RHOQ GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8T1P4", "map_id": "A0A6I8T1P4", "name": "dlc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000005630", "map_id": "ENSXETG00000005630", "name": "dlc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337474", "map_id": "none", "name": "RHOQ translocates to the Golgi-associated vesicle membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10337472", "map_id": "none", "name": "RHOQ:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane", "complex": "true" }, { "id": "reaction_10337263", "map_id": "none", "name": "RHOB binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337259", "map_id": "none", "name": "RHOB effectors (plasma membrane)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10337261", "map_id": "none", "name": "RHOB:GTP:cytosolic RHOB effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10338159", "map_id": "none", "name": "RHOB binds effectors on endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10338155", "map_id": "none", "name": "RHOB endosome effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8R8W7", "map_id": "A0A6I8R8W7", "name": "rhpn2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000018271", "map_id": "ENSXETG00000018271", "name": "rhpn2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10338157", "map_id": "none", "name": "RHOB:GTP:RHOB endosome effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10337240", "map_id": "none", "name": "RHOB GAPs stimulate RHOB GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337201", "map_id": "none", "name": "RHOB:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10337237", "map_id": "none", "name": "RHOB GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10337243", "map_id": "none", "name": "RHOB GEFs activate RHOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10316060", "map_id": "A0A6I8QGS5", "name": "arhgef17", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10337211", "map_id": "none", "name": "GDIs block activation of RHOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337205", "map_id": "F7D6Y2", "name": "arhgdig", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10337209", "map_id": "none", "name": "RHOB:GDP:RHOB GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10338161", "map_id": "none", "name": "RHOB translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10337468", "map_id": "none", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337449", "map_id": "none", "name": "RHOT2:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q6DIS1", "map_id": "Q6DIS1", "name": "rhot2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000007838", "map_id": "ENSXETT00000007838", "name": "rhot2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337465", "map_id": "none", "name": "RHOT2:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10337463", "map_id": "none", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337459", "map_id": "none", "name": "RHOT2 effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8RC59", "map_id": "A0A6I8RC59", "name": "trak1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000013857", "map_id": "ENSXETG00000013857", "name": "trak1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RIZ7", "map_id": "A0A6I8RIZ7", "name": "trak2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000032904", "map_id": "ENSXETG00000032904", "name": "trak2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337461", "map_id": "none", "name": "RHOT2:GTP:RHOT2 effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10329821", "map_id": "none", "name": "factor IXa associates with cell membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10312873", "map_id": "none", "name": "factor IXa", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q5M8Y0", "map_id": "Q5M8Y0", "name": "f9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312962", "map_id": "none", "name": "factor IXa", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10312988", "map_id": "none", "name": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10312972", "map_id": "none", "name": "Plasma kallikrein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10312986", "map_id": "none", "name": "kallikrein:alpha2-macroglobulin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10329823", "map_id": "none", "name": "factor VIIIa associates with cell membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10312938", "map_id": "none", "name": "factor VIIIa", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8SC83", "map_id": "A0A6I8SC83", "name": "Factor VIII precursor", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312956", "map_id": "none", "name": "factor VIIIa", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10338059", "map_id": "none", "name": "FIX is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10338057", "map_id": "Q5M8Y0", "name": "f9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10312867", "map_id": "Q5M8Y0", "name": "f9", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10338055", "map_id": "none", "name": "Factor VIIIa dissociates ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10312934", "map_id": "A0A6I8SC83", "name": "factor VIIIa A2 polypeptide", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10338053", "map_id": "none", "name": "factor VIIIa A1:A3-C1-C2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10312966", "map_id": "none", "name": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10312964", "map_id": "none", "name": "factor VIIIa:factor IXa", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10338033", "map_id": "none", "name": "FVIII is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10331360", "map_id": "A0A6I8SC83", "name": "Factor VIII precursor", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10312922", "map_id": "none", "name": "factor VIII", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10312930", "map_id": "none", "name": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10312926", "map_id": "none", "name": "von Willibrand factor multimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "F6TMK5", "map_id": "F6TMK5", "name": "camsap1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000046700", "map_id": "ENSXETT00000046700", "name": "camsap1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312928", "map_id": "none", "name": "factor VIII:von Willebrand factor multimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10330109", "map_id": "none", "name": "GLI translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5263228", "compartment_display": "ciliary tip" }, { "id": "species_10330107", "map_id": "A0A6I8QGB6", "name": "phospho-gli1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "false" }, { "id": "ENSXETG00000036606", "map_id": "ENSXETG00000036606", "name": "phospho-gli1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330101", "map_id": "A0A6I8QGB6", "name": "phospho-gli1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10330074", "map_id": "none", "name": "PTCH is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_261122", "compartment_display": "ciliary membrane" }, { "id": "species_10330070", "map_id": "A0A6I8QDD8", "name": "ptch1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_261122", "compartment_display": "ciliary membrane", "complex": "false" }, { "id": "species_10330072", "map_id": "A0A6I8QDD8", "name": "ptch1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane", "complex": "false" }, { "id": "reaction_10330132", "map_id": "none", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10330129", "map_id": "none", "name": "2p-GLI:SPOP:CUL3:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q6P8B3", "map_id": "Q6P8B3", "name": "spop", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000057841", "map_id": "ENSXETT00000057841", "name": "spop", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330125", "map_id": "none", "name": "ub-2p-GLI2,3:SPOP:CUL3:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10330098", "map_id": "none", "name": "GPR161 is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_261122", "compartment_display": "ciliary membrane" }, { "id": "species_10329842", "map_id": "B3DM66", "name": "gpr161", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_261122", "compartment_display": "ciliary membrane", "complex": "false" }, { "id": "ENSXETG00000002410", "map_id": "ENSXETG00000002410", "name": "gpr161", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10330096", "map_id": "B3DM66", "name": "gpr161", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane", "complex": "false" }, { "id": "reaction_10329881", "map_id": "none", "name": "TRIP11:IFT20 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10329879", "map_id": "none", "name": "IFT20:TRIP11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "A0A6I8SZZ2", "map_id": "A0A6I8SZZ2", "name": "trip11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000015833", "map_id": "ENSXETG00000015833", "name": "trip11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q66KL7", "map_id": "Q66KL7", "name": "ift20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000069320", "map_id": "ENSXETT00000069320", "name": "ift20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10329873", "map_id": "Q66KL7", "name": "ift20", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10329877", "map_id": "A0A6I8SZZ2", "name": "trip11", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10321867", "map_id": "none", "name": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1183111", "map_id": "none", "name": "Protein-L-arginine", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29382", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1183191", "map_id": "none", "name": "Protein-L-citrulline", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10321864", "map_id": "none", "name": "PADIs:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10328860", "map_id": "none", "name": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328853", "map_id": "none", "name": "MeK37-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10328857", "map_id": "Q5U263", "name": "kdm2a", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000070583", "map_id": "ENSXETT00000070583", "name": "kdm2a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10327327", "map_id": "none", "name": "KDM1A, KDM1B demethylate MeK5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10327318", "map_id": "none", "name": "MeK5-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10327324", "map_id": "A0A6I8S021", "name": "kdm1b", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000015429", "map_id": "ENSXETG00000015429", "name": "kdm1b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328879", "map_id": "none", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328864", "map_id": "none", "name": "MeK10-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10328876", "map_id": "none", "name": "KDM3A,KDM3B,KDM7A,PHF2:ARID5B,PHF8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q08D35", "map_id": "Q08D35", "name": "kdm7a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000002669", "map_id": "ENSXETG00000002669", "name": "kdm7a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q587", "map_id": "A0A6I8Q587", "name": "kdm3b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000006700", "map_id": "ENSXETG00000006700", "name": "kdm3b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10330334", "map_id": "none", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10330190", "map_id": "none", "name": "Me3K28-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10328898", "map_id": "none", "name": "Me2K28-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10328914", "map_id": "none", "name": "KDM6A,KDM6B,KDM6C,KDM7A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8S4K7", "map_id": "A0A6I8S4K7", "name": "kdm6a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000004822", "map_id": "ENSXETG00000004822", "name": "kdm6a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328890", "map_id": "none", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328881", "map_id": "none", "name": "Me2K5-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10328885", "map_id": "F6Z9Z5", "name": "kdm4b", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETT00000007540", "map_id": "ENSXETT00000007540", "name": "kdm4b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328917", "map_id": "none", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328906", "map_id": "none", "name": "MeK28-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10330324", "map_id": "none", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10329431", "map_id": "none", "name": "Me3K5-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10330320", "map_id": "none", "name": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10330145", "map_id": "none", "name": "Me2K37-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10330338", "map_id": "none", "name": "KDM1A, KDM1B demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10330322", "map_id": "none", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328862", "map_id": "none", "name": "Me2K10-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10327428", "map_id": "none", "name": "PADI4 deiminates Histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10327386", "map_id": "none", "name": "MeR3-replicative histone H3, MeR9-replicative histone H3, MeR18-replicative histone H3, Me27-replicatve histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_76230", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10327417", "map_id": "none", "name": "Cit3-replicative histone H3, Cit9-replicative histone H3, Cit18-replicative histone H3, Cit27-replicative histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10327419", "map_id": "F6YPC2", "name": "padi2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10329663", "map_id": "none", "name": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10326319", "map_id": "A0A6I8RKR7", "name": "MeK-HIST1H4A", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10330137", "map_id": "none", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10330134", "map_id": "none", "name": "WHSC1L1, Core MLL complex, SMYD3, SETD3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "B7ZUF3", "map_id": "B7ZUF3", "name": "setd3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000065894", "map_id": "ENSXETT00000065894", "name": "setd3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S8Z5", "map_id": "A0A6I8S8Z5", "name": "smyd3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040375", "map_id": "ENSXETG00000040375", "name": "smyd3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335723", "map_id": "none", "name": "SETD6 methylates RELA in the NFkB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10335716", "map_id": "none", "name": "NFkB Complex with MeK310-RELA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10335720", "map_id": "A4QNG5", "name": "setd6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000013793", "map_id": "ENSXETG00000013793", "name": "setd6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329450", "map_id": "none", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10329447", "map_id": "none", "name": "Core MLL complex, SMYD3, PRDM9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8RD53", "map_id": "A0A6I8RD53", "name": "PRDM9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039708", "map_id": "ENSXETG00000039708", "name": "PRDM9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SUP9", "map_id": "A0A6I8SUP9", "name": "znf91", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000037286", "map_id": "ENSXETG00000037286", "name": "znf91", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328986", "map_id": "none", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328969", "map_id": "none", "name": "Me3K10-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10328983", "map_id": "none", "name": "SUV39H1, SUV39H2, SETDB1, SETDB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q28CQ7", "map_id": "Q28CQ7", "name": "suv39h2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000005401", "map_id": "ENSXETG00000005401", "name": "suv39h2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A4IGY9", "map_id": "A4IGY9", "name": "setdb2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000015666", "map_id": "ENSXETG00000015666", "name": "setdb2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q08D57", "map_id": "Q08D57", "name": "setd1b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000003760", "map_id": "ENSXETG00000003760", "name": "setd1b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328999", "map_id": "none", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10328996", "map_id": "none", "name": "SETD3, SETD7, WHSC1L1, Core MLL complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q4QQN5", "map_id": "Q4QQN5", "name": "setd7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000036910", "map_id": "ENSXETT00000036910", "name": "setd7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10314063", "map_id": "none", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_189049", "map_id": "CHEBI:15824", "name": "Fru", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10314060", "map_id": "C6F3T7", "name": "KiSSR", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10336095", "map_id": "none", "name": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_189227", "map_id": "none", "name": "Gal, Glc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_189254", "map_id": "none", "name": "Gal, Glc", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10336092", "map_id": "A0A6I8Q1E4", "name": "slc5a1.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000036486", "map_id": "ENSXETG00000036486", "name": "slc5a1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317056", "map_id": "none", "name": "DSCAM/DSCAML1 homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10317052", "map_id": "A0A6I8S5X4", "name": "dscaml1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000003741", "map_id": "ENSXETG00000003741", "name": "dscaml1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10317054", "map_id": "none", "name": "DSCAM/DSCAML1 homodimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8S5X4", "map_id": "A0A6I8S5X4", "name": "dscaml1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10322283", "map_id": "none", "name": "Hemoglobin A is protonated and carbamated causing release of oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10334487", "map_id": "none", "name": "CYB5Rs reduce MetHb to HbA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10334462", "map_id": "none", "name": "MetHb", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10334468", "map_id": "none", "name": "HbA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10334484", "map_id": "none", "name": "CYB5Rs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q5BJ68", "map_id": "Q5BJ68", "name": "cyb5r2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000096157", "map_id": "ENSXETT00000096157", "name": "cyb5r2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SMQ8", "map_id": "A0A6I8SMQ8", "name": "CYB5R4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035257", "map_id": "ENSXETG00000035257", "name": "CYB5R4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28CZ9", "map_id": "Q28CZ9", "name": "cyb5r4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000022592", "map_id": "ENSXETG00000022592", "name": "cyb5r4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10322214", "map_id": "none", "name": "CA4:Zn2+ hydrates CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10335965", "map_id": "none", "name": "LDL translocates from endosome lumen to lysosome lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171907", "compartment_display": "endosome lumen" }, { "id": "species_10335963", "map_id": "none", "name": "LDL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "true" }, { "id": "species_10335734", "map_id": "none", "name": "LDL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10335741", "map_id": "none", "name": "LIPA hydrolyses sterol esters to sterols and fatty acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_8848047", "map_id": "CHEBI:16113", "name": "CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10335736", "map_id": "none", "name": "LIPA-degraded LDL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_8865666", "map_id": "CHEBI:35366", "name": "FA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10335738", "map_id": "F7CN53", "name": "lipa", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "ENSXETT00000020371", "map_id": "ENSXETT00000020371", "name": "lipa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334653", "map_id": "none", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10334650", "map_id": "A0A6I8SL01", "name": "nceh1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000038694", "map_id": "ENSXETG00000038694", "name": "nceh1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335991", "map_id": "none", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8876704", "map_id": "CHEBI:17002", "name": "CHEST", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10335988", "map_id": "A0A6I8T0J2", "name": "LOC101730739", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "ENSXETG00000034253", "map_id": "ENSXETG00000034253", "name": "LOC101730739", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335379", "map_id": "none", "name": "HDLBP binds HDL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10335375", "map_id": "A0A6I8S7E7", "name": "hdlbp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000012164", "map_id": "ENSXETG00000012164", "name": "hdlbp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10335377", "map_id": "none", "name": "HDLBP:HDL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8S7E7", "map_id": "A0A6I8S7E7", "name": "hdlbp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10317284", "map_id": "none", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_382577", "map_id": "CHEBI:15904", "name": "LCFA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_382571", "map_id": "CHEBI:15904", "name": "LCFA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10322479", "map_id": "none", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_1369066", "map_id": "CHEBI:8337", "name": "porphyrin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1369027", "map_id": "CHEBI:8337", "name": "porphyrin", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10322476", "map_id": "none", "name": "MTABC3 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q08D64", "map_id": "Q08D64", "name": "abcb6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000030397", "map_id": "ENSXETT00000030397", "name": "abcb6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318119", "map_id": "none", "name": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10318116", "map_id": "Q0P4G6", "name": "slc2a10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETT00000007515", "map_id": "ENSXETT00000007515", "name": "slc2a10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335959", "map_id": "none", "name": "SLC50A1 transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10335956", "map_id": "Q5EAL3", "name": "slc50a1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000019427", "map_id": "ENSXETG00000019427", "name": "slc50a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318099", "map_id": "none", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428819", "map_id": "none", "name": "hexoses transported by GLUT7/11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_428802", "map_id": "none", "name": "hexoses transported by GLUT7/11", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10318096", "map_id": "C6F3T7", "name": "KiSSR", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10318281", "map_id": "none", "name": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_71067", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10318278", "map_id": "none", "name": "SLC40A1:HEPH:6Cu2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8SBF5", "map_id": "A0A6I8SBF5", "name": "SLC40A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000041263", "map_id": "ENSXETG00000041263", "name": "SLC40A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7EFD4", "map_id": "F7EFD4", "name": "LOC100491248", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000006578", "map_id": "ENSXETT00000006578", "name": "LOC100491248", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318333", "map_id": "none", "name": "VMAT1/2 can mediate the transport of biogenic amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_444154", "map_id": "none", "name": "Biogenic amines transported by VMAT1/2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_444152", "map_id": "none", "name": "Biogenic amines transported by VMAT1/2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_374932", "compartment_display": "clathrin-sculpted monoamine transport vesicle lumen", "complex": "true" }, { "id": "species_10318330", "map_id": "none", "name": "VMAT1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_374940", "compartment_display": "clathrin-sculpted monoamine transport vesicle membrane", "complex": "true" }, { "id": "F6YMA0", "map_id": "F6YMA0", "name": "hormad1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000019549", "map_id": "ENSXETT00000019549", "name": "hormad1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R508", "map_id": "A0A6I8R508", "name": "SLC18A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318203", "map_id": "none", "name": "MATEs mediate extrusion of xenobiotics", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_446589", "map_id": "none", "name": "MATE substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:8428", "map_id": "CHEBI:8428", "name": "CHEBI:8428", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:46020", "map_id": "CHEBI:46020", "name": "CHEBI:46020", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:42820", "map_id": "CHEBI:42820", "name": "CHEBI:42820", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:641", "map_id": "CHEBI:641", "name": "CHEBI:641", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:6801", "map_id": "CHEBI:6801", "name": "CHEBI:6801", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16737", "map_id": "CHEBI:16737", "name": "CHEBI:16737", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_446597", "map_id": "none", "name": "MATE substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10318200", "map_id": "none", "name": "MATE1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A4IIS8", "map_id": "A4IIS8", "name": "slc47a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000022931", "map_id": "ENSXETG00000022931", "name": "slc47a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8STL3", "map_id": "A0A6I8STL3", "name": "LOC100489305", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039254", "map_id": "ENSXETG00000039254", "name": "LOC100489305", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10319068", "map_id": "none", "name": "SLC22A12 exchanges extracellular urate for cytosolic LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429056", "map_id": "CHEBI:17775", "name": "urate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_30034", "map_id": "CHEBI:17775", "name": "urate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10319065", "map_id": "A0A6I8RMY7", "name": "slc22a6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000023239", "map_id": "ENSXETG00000023239", "name": "slc22a6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10319063", "map_id": "none", "name": "OAT2 and OAT4 mediate transport of sulphate conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_561071", "map_id": "none", "name": "OAT2/4 sulfate conjugate substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_561062", "map_id": "none", "name": "OAT2/4 sulfate conjugate substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_561075", "map_id": "CHEBI:16810", "name": "2OG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10319060", "map_id": "A0A6I8RMY7", "name": "slc22a6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10319058", "map_id": "none", "name": "OAT1-3 transport organic anions with antiport of dicarboxylic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_561049", "map_id": "none", "name": "OAT1-3 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:104011", "map_id": "CHEBI:104011", "name": "CHEBI:104011", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:2453", "map_id": "CHEBI:2453", "name": "CHEBI:2453", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_561078", "map_id": "none", "name": "OAT1-3 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10319055", "map_id": "none", "name": "OAT1-3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8QMN4", "map_id": "A0A6I8QMN4", "name": "SLC22A8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035704", "map_id": "ENSXETG00000035704", "name": "SLC22A8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RMY7", "map_id": "A0A6I8RMY7", "name": "slc22a6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318169", "map_id": "none", "name": "NaS2 co-transports sulphate and two sodium ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_427648", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_174375", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10318166", "map_id": "A0A6I8PVH5", "name": "slc13a4l", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000010608", "map_id": "ENSXETG00000010608", "name": "slc13a4l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10320605", "map_id": "none", "name": "apo-Transferrin dissociates from the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947586", "compartment_display": "external side of plasma membrane" }, { "id": "species_10320599", "map_id": "none", "name": "apoTF:TFRC dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10318912", "map_id": "Q501K5", "name": "tf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10320572", "map_id": "none", "name": "TFRC dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10320588", "map_id": "none", "name": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10320576", "map_id": "none", "name": "holoTF:TFRC dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10320586", "map_id": "none", "name": "holoTF:TFRC dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10320601", "map_id": "none", "name": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10320597", "map_id": "none", "name": "apoTF:TFRC dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10320603", "map_id": "none", "name": "Fe3+ dissociates from holoTF:TFRC dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171907", "compartment_display": "endosome lumen" }, { "id": "species_917966", "map_id": "CHEBI:29034", "name": "Fe3+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "false" }, { "id": "reaction_10320612", "map_id": "none", "name": "TFRC dimer binds 2xholoTF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10320574", "map_id": "none", "name": "holoTF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10331142", "map_id": "none", "name": "HFE binds TFRC dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10331138", "map_id": "none", "name": "Homologues of HFE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10331140", "map_id": "none", "name": "HFE:TFRC dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10320595", "map_id": "none", "name": "STEAP3-like proteins reduce Fe3+ to Fe2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171907", "compartment_display": "endosome lumen" }, { "id": "species_917882", "map_id": "CHEBI:10545", "name": "e-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "species_917810", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "false" }, { "id": "reaction_10331101", "map_id": "none", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5690881", "map_id": "none", "name": "4Fe-4S", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10331097", "map_id": "A0A6I8SX09", "name": "aco1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000009184", "map_id": "ENSXETG00000009184", "name": "aco1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10331099", "map_id": "none", "name": "ACO1:4Fe-4S", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8SX09", "map_id": "A0A6I8SX09", "name": "aco1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10331117", "map_id": "none", "name": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5691135", "map_id": "CHEBI:78619", "name": "Fe(3+)O(OH)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10331114", "map_id": "none", "name": "FTMT 24mer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10320607", "map_id": "none", "name": "apoTF binds 2Fe3+ to form holoTF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10320566", "map_id": "none", "name": "CYBRD1:Heme reduces Fe3+ to Fe2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_917828", "map_id": "CHEBI:10545", "name": "e-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10320563", "map_id": "none", "name": "CYBRD1:Heme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q5CZL8", "map_id": "Q5CZL8", "name": "cybrd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000040828", "map_id": "ENSXETT00000040828", "name": "cybrd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10331110", "map_id": "none", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_389545", "map_id": "CHEBI:151", "name": "ISCIT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10320610", "map_id": "none", "name": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947586", "compartment_display": "external side of plasma membrane" }, { "id": "reaction_10323458", "map_id": "none", "name": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5691103", "map_id": "CHEBI:78619", "name": "Fe(3+)O(OH)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10323455", "map_id": "none", "name": "Ferritin Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10320671", "map_id": "none", "name": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10320666", "map_id": "none", "name": "ATP1A:ATP1B:FXYD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q6P617", "map_id": "Q6P617", "name": "atp1b3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000095333", "map_id": "ENSXETT00000095333", "name": "atp1b3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8QKL0", "map_id": "A0A6I8QKL0", "name": "atp1a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000020366", "map_id": "ENSXETG00000020366", "name": "atp1a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S802", "map_id": "A0A6I8S802", "name": "fxyd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038243", "map_id": "ENSXETG00000038243", "name": "fxyd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10320669", "map_id": "none", "name": "ATP1A:ATP1B:FXYD:cardiac glycosides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10338110", "map_id": "none", "name": "ATP1A:ATP1B:FXYD binds cardiac glycosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9684063", "map_id": "none", "name": "cardiac glycosides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10329512", "map_id": "none", "name": "ATP13A4,5 transport divalent ions from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5252122", "map_id": "CHEBI:60240", "name": "divalent metal cation", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_5252016", "map_id": "CHEBI:60240", "name": "divalent metal cation", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10329509", "map_id": "none", "name": "ATP13A4, 5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F7C820", "map_id": "F7C820", "name": "cpm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000003028", "map_id": "ENSXETT00000003028", "name": "cpm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R4Z6", "map_id": "A0A6I8R4Z6", "name": "ATP13A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034939", "map_id": "ENSXETG00000034939", "name": "ATP13A5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10320699", "map_id": "none", "name": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_947594", "map_id": "none", "name": "APLs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_947586", "compartment_display": "external side of plasma membrane", "complex": "true" }, { "id": "species_947588", "map_id": "none", "name": "APLs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane", "complex": "true" }, { "id": "species_10320696", "map_id": "none", "name": "P-type ATPases type IV", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q5BL50", "map_id": "Q5BL50", "name": "atp8b1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000020878", "map_id": "ENSXETG00000020878", "name": "atp8b1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10318054", "map_id": "none", "name": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_111875", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10318040", "map_id": "none", "name": "ATP2A1-3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10318052", "map_id": "none", "name": "p-S16-PLN pentamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_261659", "compartment_display": "sarcoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A6I8ST89", "map_id": "A0A6I8ST89", "name": "phospho-pln", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036412", "map_id": "ENSXETG00000036412", "name": "phospho-pln", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318047", "map_id": "none", "name": "PLN pentamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_261659", "compartment_display": "sarcoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10329566", "map_id": "none", "name": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10329563", "map_id": "A0A6I8QID6", "name": "mrs2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "ENSXETG00000021985", "map_id": "ENSXETG00000021985", "name": "mrs2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337028", "map_id": "none", "name": "Neuroglobin:oxygen dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10337024", "map_id": "none", "name": "NGB:ferroheme b:O2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q575T7", "map_id": "Q575T7", "name": "ngb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000083304", "map_id": "ENSXETT00000083304", "name": "ngb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337022", "map_id": "none", "name": "NGB:ferroheme b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10337063", "map_id": "none", "name": "CYGB:O2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10337026", "map_id": "none", "name": "Neuroglobin binds oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10329738", "map_id": "none", "name": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10329735", "map_id": "none", "name": "AKAP9:KCNQ1 tetramer:KCNE dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8SN44", "map_id": "A0A6I8SN44", "name": "KCNE1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000041349", "map_id": "ENSXETG00000041349", "name": "KCNE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q2V9", "map_id": "A0A6I8Q2V9", "name": "kcne2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000032386", "map_id": "ENSXETG00000032386", "name": "kcne2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SMY0", "map_id": "A0A6I8SMY0", "name": "akap9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000003440", "map_id": "ENSXETG00000003440", "name": "akap9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q0D6", "map_id": "A0A6I8Q0D6", "name": "LOC100492908", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034068", "map_id": "ENSXETG00000034068", "name": "LOC100492908", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329869", "map_id": "none", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_975622", "map_id": "CHEBI:17898", "name": "atRAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_975599", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10329660", "map_id": "none", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10329657", "map_id": "none", "name": "ADH1A,1C,4 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10329646", "map_id": "none", "name": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10329643", "map_id": "none", "name": "RDH10,16,DHRS9,RDHE2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A6I8PYC1", "map_id": "A0A6I8PYC1", "name": "LOC100498066", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033315", "map_id": "ENSXETG00000033315", "name": "LOC100498066", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5XGF7", "map_id": "Q5XGF7", "name": "rdh10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000025854", "map_id": "ENSXETT00000025854", "name": "rdh10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6Z4N6", "map_id": "F6Z4N6", "name": "DHRS9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000035399", "map_id": "ENSXETT00000035399", "name": "DHRS9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329909", "map_id": "none", "name": "CRABP1 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10329651", "map_id": "A0A6I8QHI5", "name": "crabp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000040354", "map_id": "ENSXETG00000040354", "name": "crabp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5334816", "map_id": "CHEBI:15367", "name": "atRA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10329653", "map_id": "none", "name": "SUMO-CRABP1:atRA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8QHI5", "map_id": "A0A6I8QHI5", "name": "crabp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329655", "map_id": "none", "name": "CYP26A1,B1,C1 4-hydroxylate atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5362521", "map_id": "CHEBI:63795", "name": "4OH-atRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10332441", "map_id": "none", "name": "NRXNs bind NLGNs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10332437", "map_id": "none", "name": "NLGN2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8S9J2", "map_id": "A0A6I8S9J2", "name": "nlgn2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035941", "map_id": "ENSXETG00000035941", "name": "nlgn2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10332431", "map_id": "A0A6I8Q952", "name": "nrxn3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000011090", "map_id": "ENSXETG00000011090", "name": "nrxn3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10332439", "map_id": "none", "name": "NRXNs:NLGN dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8Q952", "map_id": "A0A6I8Q952", "name": "nrxn3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10332482", "map_id": "none", "name": "LRRTMs bind NRXNs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10332478", "map_id": "none", "name": "LRRTMs", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10332480", "map_id": "none", "name": "NRXNs:LRRTMs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10313806", "map_id": "none", "name": "Secretion and activation of the latent large complex of TGF-beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10313438", "map_id": "none", "name": "Large latent complex of TGFB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10313444", "map_id": "none", "name": "Dimeric TGFB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10313440", "map_id": "none", "name": "Latent TGF-beta-1 is cleaved by furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10313434", "map_id": "none", "name": "Pre-TGFB1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10334815", "map_id": "none", "name": "KLK5 cleaves and activates CELA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10334808", "map_id": "F6R841", "name": "cela1.1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETT00000031018", "map_id": "ENSXETT00000031018", "name": "cela1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10334810", "map_id": "F6R841", "name": "cela1.1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10334812", "map_id": "F6R841", "name": "cela1.1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10334804", "map_id": "F7EHU5", "name": "ctsg", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10334837", "map_id": "none", "name": "KLK5 cleaves and activates KLK8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10334831", "map_id": "F7EHU5", "name": "ctsg", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10334835", "map_id": "F7EHU5", "name": "ctsg", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10334833", "map_id": "F7EHU5", "name": "ctsg", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10332400", "map_id": "none", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6789319", "map_id": "CHEBI:33575", "name": "RCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10332391", "map_id": "F7CN53", "name": "lipa", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10312850", "map_id": "none", "name": "sequestered tissue factor -> tissue factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10312848", "map_id": "A0A6I8PS78", "name": "f3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000030465", "map_id": "ENSXETG00000030465", "name": "f3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10312846", "map_id": "A0A6I8PS78", "name": "f3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10322381", "map_id": "none", "name": "Association of Acrosin Heavy and Light Chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10322369", "map_id": "none", "name": "Homologues of ACR(43-343)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8SN95", "map_id": "A0A6I8SN95", "name": "acr.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000034074", "map_id": "ENSXETG00000034074", "name": "acr.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RYQ2", "map_id": "A0A6I8RYQ2", "name": "LOC100487305", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033999", "map_id": "ENSXETG00000033999", "name": "LOC100487305", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R444", "map_id": "A0A6I8R444", "name": "ACR(20-421)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036832", "map_id": "ENSXETG00000036832", "name": "ACR(20-421)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10322377", "map_id": "none", "name": "Homologues of ACR(20-42)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10322379", "map_id": "none", "name": "Acrosin Heavy:light chain", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10322392", "map_id": "none", "name": "Acrosin Cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10322389", "map_id": "none", "name": "Homologues of ACR(20-421)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10328392", "map_id": "none", "name": "DAAM1 recruits PFN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10315909", "map_id": "A0A6I8RDQ2", "name": "PFN1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "ENSXETG00000036913", "map_id": "ENSXETG00000036913", "name": "PFN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328390", "map_id": "none", "name": "ppDVL:DAAM1:PFN1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8RDQ2", "map_id": "A0A6I8RDQ2", "name": "PFN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10328309", "map_id": "none", "name": "DVL is recruited to the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10328305", "map_id": "none", "name": "p-DVL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10328303", "map_id": "none", "name": "WNT:FZD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q5BL72", "map_id": "Q5BL72", "name": "fzd7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000027115", "map_id": "ENSXETT00000027115", "name": "fzd7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10328307", "map_id": "none", "name": "WNT:FZD:pDVL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10328295", "map_id": "none", "name": "ppDVL recruits RAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10318239", "map_id": "none", "name": "VAV1 Rho/Rac effectors:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10328293", "map_id": "none", "name": "pp-DVL:RAC:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10316717", "map_id": "none", "name": "Translocation of active caspase-8 to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10316715", "map_id": "none", "name": "active caspase-8 ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10335361", "map_id": "none", "name": "RNA demethylases demethylate N6-methyladenosine RNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_8857725", "map_id": "CHEBI:21891", "name": "N6-methyladenosine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_111793", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10335358", "map_id": "none", "name": "RNA demethylases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "F6U6S7", "map_id": "F6U6S7", "name": "fto", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000012796", "map_id": "ENSXETT00000012796", "name": "fto", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q66JG8", "map_id": "Q66JG8", "name": "alkbh5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000012702", "map_id": "ENSXETT00000012702", "name": "alkbh5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337796", "map_id": "none", "name": "CEBPA binds CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10311327", "map_id": "F6T0J1", "name": "cdk19", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10337788", "map_id": "A0A6I8R9D5", "name": "cebpe", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000039574", "map_id": "ENSXETG00000039574", "name": "cebpe", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337794", "map_id": "none", "name": "CEBPA:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8R9D5", "map_id": "A0A6I8R9D5", "name": "cebpe", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10337792", "map_id": "none", "name": "CEBPA binds CDK4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10337784", "map_id": "A0A6I8R6Z7", "name": "cdk4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000035239", "map_id": "ENSXETG00000035239", "name": "cdk4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10337790", "map_id": "none", "name": "CEBPA:CDK4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A6I8R6Z7", "map_id": "A0A6I8R6Z7", "name": "cdk4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10334445", "map_id": "none", "name": "Keratin tetramers bind to form unit length filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10334433", "map_id": "none", "name": "Keratin tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8QYX0", "map_id": "A0A6I8QYX0", "name": "krt62", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000039697", "map_id": "ENSXETG00000039697", "name": "krt62", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7AZB6", "map_id": "F7AZB6", "name": "krt19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000027288", "map_id": "ENSXETT00000027288", "name": "krt19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8S6R3", "map_id": "A0A6I8S6R3", "name": "krt15.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000029985", "map_id": "ENSXETG00000029985", "name": "krt15.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8R639", "map_id": "A0A6I8R639", "name": "KRT39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000040013", "map_id": "ENSXETG00000040013", "name": "KRT39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6P864", "map_id": "Q6P864", "name": "krt18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000005611", "map_id": "ENSXETG00000005611", "name": "krt18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6SZX5", "map_id": "F6SZX5", "name": "krt12.6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000022390", "map_id": "ENSXETT00000022390", "name": "krt12.6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10334437", "map_id": "none", "name": "Keratin unit length filament", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10334431", "map_id": "none", "name": "Keratin type I binds keratin type II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10334213", "map_id": "none", "name": "Keratin type I", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10334427", "map_id": "none", "name": "Keratin type II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10334429", "map_id": "none", "name": "Keratin heterodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10334443", "map_id": "none", "name": "Keratin filament formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10334439", "map_id": "none", "name": "Keratin filament units", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10334441", "map_id": "none", "name": "Keratin filament", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10334449", "map_id": "none", "name": "Formation of tonofilament bundles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10334447", "map_id": "none", "name": "Keratin tonofilament", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10334435", "map_id": "none", "name": "Keratin type I/type II heterodimers form tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10331235", "map_id": "none", "name": "NPR2 binds NPPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10331227", "map_id": "A0A6I8SMD0", "name": "nppc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "ENSXETG00000041083", "map_id": "ENSXETG00000041083", "name": "nppc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10331231", "map_id": "A0A6I8SDR4", "name": "npr2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000031971", "map_id": "ENSXETG00000031971", "name": "npr2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10331233", "map_id": "none", "name": "NPR2:NPPC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8SDR4", "map_id": "A0A6I8SDR4", "name": "npr2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SMD0", "map_id": "A0A6I8SMD0", "name": "nppc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329753", "map_id": "none", "name": "DMPK phosphorylates PLN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10329750", "map_id": "none", "name": "DMPK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_261659", "compartment_display": "sarcoplasmic reticulum membrane", "complex": "true" }, { "id": "F6V346", "map_id": "F6V346", "name": "stk38", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000036273", "map_id": "ENSXETT00000036273", "name": "stk38", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10329776", "map_id": "none", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10329773", "map_id": "none", "name": "KCNK dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F6WH56", "map_id": "F6WH56", "name": "kcnk12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000048965", "map_id": "ENSXETT00000048965", "name": "kcnk12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10312747", "map_id": "none", "name": "Activation of conventional Protein Kinase C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10312745", "map_id": "none", "name": "Activated conventional protein kinase C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10318808", "map_id": "none", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10318758", "map_id": "none", "name": "Platelet alpha granule contents", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114506", "compartment_display": "platelet alpha granule lumen", "complex": "true" }, { "id": "A0A6I8S6I0", "map_id": "A0A6I8S6I0", "name": "fermt3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000027692", "map_id": "ENSXETG00000027692", "name": "fermt3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PY35", "map_id": "A0A6I8PY35", "name": "pcyox1l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000033269", "map_id": "ENSXETG00000033269", "name": "pcyox1l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7B6V1", "map_id": "F7B6V1", "name": "apool", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000038623", "map_id": "ENSXETT00000038623", "name": "apool", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8Q251", "map_id": "A0A6I8Q251", "name": "MMRN1(20-1228)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000030791", "map_id": "ENSXETG00000030791", "name": "MMRN1(20-1228)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8PVG7", "map_id": "A0A6I8PVG7", "name": "fetub", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031284", "map_id": "ENSXETG00000031284", "name": "fetub", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F7C1U1", "map_id": "F7C1U1", "name": "serpinc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000043296", "map_id": "ENSXETT00000043296", "name": "serpinc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5BKJ7", "map_id": "Q5BKJ7", "name": "tor4a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000050639", "map_id": "ENSXETT00000050639", "name": "tor4a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8STH4", "map_id": "A0A6I8STH4", "name": "lefty", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000035410", "map_id": "ENSXETG00000035410", "name": "lefty", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F6YIE1", "map_id": "F6YIE1", "name": "tgm3l.7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000016028", "map_id": "ENSXETT00000016028", "name": "tgm3l.7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q66JG0", "map_id": "Q66JG0", "name": "ola1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000008500", "map_id": "ENSXETG00000008500", "name": "ola1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318806", "map_id": "none", "name": "Platelet alpha granule contents", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10318868", "map_id": "none", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10318842", "map_id": "none", "name": "Platelet dense granule content", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114524", "compartment_display": "platelet dense granule lumen", "complex": "true" }, { "id": "B0BLS9", "map_id": "B0BLS9", "name": "fam3c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000049183", "map_id": "ENSXETT00000049183", "name": "fam3c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28F45", "map_id": "Q28F45", "name": "ctsw", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000055303", "map_id": "ENSXETT00000055303", "name": "ctsw", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28HY7", "map_id": "Q28HY7", "name": "cdc37l1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000000595", "map_id": "ENSXETG00000000595", "name": "cdc37l1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RL39", "map_id": "A0A6I8RL39", "name": "itih3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000006887", "map_id": "ENSXETG00000006887", "name": "itih3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8SSC0", "map_id": "A0A6I8SSC0", "name": "ITIH3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036712", "map_id": "ENSXETG00000036712", "name": "ITIH3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318866", "map_id": "none", "name": "Platelet dense granule content", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10318948", "map_id": "none", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10318936", "map_id": "none", "name": "Platelet releasate cytosolic proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6DIF4", "map_id": "Q6DIF4", "name": "wdr1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000000629", "map_id": "ENSXETG00000000629", "name": "wdr1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q28IX8", "map_id": "Q28IX8", "name": "tuba", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000019288", "map_id": "ENSXETG00000019288", "name": "tuba", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RS05", "map_id": "A0A6I8RS05", "name": "endod1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000036422", "map_id": "ENSXETG00000036422", "name": "endod1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318946", "map_id": "none", "name": "Platelet releasate cytosolic proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10318918", "map_id": "none", "name": "Release of platelet secretory granule components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10318910", "map_id": "none", "name": "Platelet releasate secretory granule proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "true" }, { "id": "F7E728", "map_id": "F7E728", "name": "scg3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000020755", "map_id": "ENSXETG00000020755", "name": "scg3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318916", "map_id": "none", "name": "Platelet releasate secretory granule proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10316707", "map_id": "none", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10316703", "map_id": "Q66IL0", "name": "chid1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "ENSXETT00000041328", "map_id": "ENSXETT00000041328", "name": "chid1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10316705", "map_id": "Q66IL0", "name": "chid1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10318882", "map_id": "none", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10318876", "map_id": "none", "name": "Platelet dense granule membrane components", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114584", "compartment_display": "platelet dense granule membrane", "complex": "true" }, { "id": "A0A6I8SL99", "map_id": "A0A6I8SL99", "name": "rab27b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000003366", "map_id": "ENSXETG00000003366", "name": "rab27b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318880", "map_id": "none", "name": "Platelet dense granule membrane components", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10318898", "map_id": "none", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10318892", "map_id": "none", "name": "Platelet alpha granule membrane components that are released on degranulation", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114510", "compartment_display": "platelet alpha granule membrane", "complex": "true" }, { "id": "A0A6I8Q083", "map_id": "A0A6I8Q083", "name": "CD109", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031004", "map_id": "ENSXETG00000031004", "name": "CD109", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10318896", "map_id": "none", "name": "Platelet alpha granule membrane components that are released on degranulation", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10318249", "map_id": "none", "name": "VAV1 is a GEF for Rho/Rac family GTPases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10318237", "map_id": "none", "name": "VAV1 Rho/Rac effectors:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10318242", "map_id": "L7N3Q8", "name": "phospho-p-Y174-VAV1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10318247", "map_id": "none", "name": "PIP3:VAV1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10318245", "map_id": "none", "name": "VAV family:PIP2", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10318123", "map_id": "none", "name": "SLP-76 stimulates PLC gamma 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10318121", "map_id": "A0A6I8SLR0", "name": "plcg2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10312756", "map_id": "A0A6I8SLR0", "name": "phospho-plcg2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10312759", "map_id": "none", "name": "PLC gamma 2-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10322394", "map_id": "none", "name": "Binding of cAMP to HCN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10322341", "map_id": "none", "name": "HCN channels", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8SMA9", "map_id": "A0A6I8SMA9", "name": "hcn1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000017714", "map_id": "ENSXETG00000017714", "name": "hcn1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A6I8RXX5", "map_id": "A0A6I8RXX5", "name": "hcn2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000031566", "map_id": "ENSXETG00000031566", "name": "hcn2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10322343", "map_id": "none", "name": "HCN channel bound to cAMP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10322346", "map_id": "none", "name": "Activation of HCN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10317036", "map_id": "none", "name": "Connexin 36 mediated neuronal gap junction communication", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_204883", "compartment_display": "cell junction" }, { "id": "species_10317033", "map_id": "none", "name": "Connexin 36 Gap Junction Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A6I8RRX1", "map_id": "A0A6I8RRX1", "name": "gjd2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000038711", "map_id": "ENSXETG00000038711", "name": "gjd2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10311663", "map_id": "none", "name": "Trimerization of the FASL:FAS receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10311659", "map_id": "none", "name": "FASL:FAS Receptor monomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10311661", "map_id": "none", "name": "FASL:FAS Receptor Trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10312086", "map_id": "none", "name": "FASL binds FAS Receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10311653", "map_id": "A0A6I8QWZ8", "name": "faslg", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10311657", "map_id": "A0A6I8PTW1", "name": "fas", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10312879", "map_id": "none", "name": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10312839", "map_id": "none", "name": "factor XIII cleaved tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10312833", "map_id": "A0A6I8PQF3", "name": "f13b", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10312877", "map_id": "none", "name": "factor XIIIa", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10326879", "map_id": "none", "name": "Hv1 Mediated H+ Permeability", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1132304", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_459", "compartment_display": "cytoplasm", "complex": "false" }, { "id": "species_10326876", "map_id": "none", "name": "HV1 Channel", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10326870", "map_id": "none", "name": "SPAM1 Binds Hyaluronic Acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10326866", "map_id": "A0A6I8PVK0", "name": "spam1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "ENSXETG00000033261", "map_id": "ENSXETG00000033261", "name": "spam1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1297302", "map_id": "CHEBI:16336", "name": "HUA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10326868", "map_id": "none", "name": "SPAM1:Hyaluronic acid", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8PVK0", "map_id": "A0A6I8PVK0", "name": "spam1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10330885", "map_id": "none", "name": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10330874", "map_id": "none", "name": "Ack-ACCS2,AcK-GLUD,AcK-IDH2,Ack-SOD2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_5688337", "map_id": "CHEBI:76279", "name": "2'-O-acetyl-ADP-ribose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5688274", "map_id": "CHEBI:17154", "name": "NAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10330876", "map_id": "none", "name": "ACCS2,GLUD,IDH2,SOD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10330882", "map_id": "none", "name": "SIRT3(?-399):Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A0A6I8PP16", "map_id": "A0A6I8PP16", "name": "sirt3.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000032567", "map_id": "ENSXETG00000032567", "name": "sirt3.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10330902", "map_id": "none", "name": "SIRT5 deacetylates Cytochrome C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_5688282", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10330893", "map_id": "none", "name": "Homologues of AcK-CYCS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "species_5688281", "map_id": "CHEBI:17154", "name": "NAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5688340", "map_id": "CHEBI:76279", "name": "2'-O-acetyl-ADP-ribose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10330899", "map_id": "none", "name": "SIRT5:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "F7DKV7", "map_id": "F7DKV7", "name": "sirt5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETT00000004834", "map_id": "ENSXETT00000004834", "name": "sirt5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10335711", "map_id": "none", "name": "MICAL1 produces NADP+, H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10335708", "map_id": "none", "name": "MICAL1:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A6I8PP59", "map_id": "A0A6I8PP59", "name": "lima1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ENSXETG00000013342", "map_id": "ENSXETG00000013342", "name": "lima1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10321770", "map_id": "none", "name": "JMJD1C demethylates H3K9 mono- and di-methylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10321761", "map_id": "none", "name": "Histone H3 mono or di-methylated at K9", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10321763", "map_id": "none", "name": "Histone H3 mono- or unmethylated at K9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10321767", "map_id": "A0A6I8QUV0", "name": "jmjd1c", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "ENSXETG00000007684", "map_id": "ENSXETG00000007684", "name": "jmjd1c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10321786", "map_id": "none", "name": "NFE2 binds the beta globin locus control region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696348", "species_10331483" ], "products": [ "species_10331485" ], "modifiers": [], "additional_components": [ "species_8959486", "species_33625", "species_8959490", "A0A6I8PSB6", "ENSXETG00000032041", "A0A6I8QSY3", "ENSXETG00000037809", "A0A6I8SNS8", "ENSXETG00000036363", "A0A6I8PSB6", "ENSXETG00000032041", "A0A6I8QSY3", "ENSXETG00000037809", "A0A6I8SNS8", "ENSXETG00000036363", "species_8959486", "species_33625", "species_8959490" ] }, "reaction_10315604": { "compartment": "compartment_876", "id": "reaction_10315604", "reactome": "R-XTR-199579", "name": "KIR2DL4 interacting with HLA-G", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315600", "species_10315598" ], "products": [ "species_10315602" ], "modifiers": [], "additional_components": [ "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8PKK9", "ENSXETG00000033246", "ENSXETG00000032630", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8PKK9", "ENSXETG00000033246" ] }, "reaction_10330788": { "compartment": "compartment_876", "id": "reaction_10330788", "reactome": "R-XTR-5685607", "name": "Sialic acid binds SIGLEC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330784", "species_1006168" ], "products": [ "species_10330786" ], "modifiers": [], "additional_components": [ "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8R800", "ENSXETG00000040970", "species_1006168", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8R800", "ENSXETG00000040970" ] }, "reaction_10314694": { "compartment": "compartment_876", "id": "reaction_10314694", "reactome": "R-XTR-199154", "name": "CD200 binds to CD200R", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314690", "species_10314686" ], "products": [ "species_10314692" ], "modifiers": [], "additional_components": [ "ENSXETG00000034946", "ENSXETG00000039727", "A0A6I8QKB5", "ENSXETG00000039727", "A0A6I8SWZ3", "ENSXETG00000034946" ] }, "reaction_10315536": { "compartment": "compartment_876", "id": "reaction_10315536", "reactome": "R-XTR-199161", "name": "Fc gamma receptors interact with antigen-bound IgG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_175973", "species_71284" ], "products": [ "species_175979", "species_71285" ], "modifiers": [ [ "species_10313553", "catalyst" ] ], "additional_components": [ "ENSXETG00000028049" ] }, "reaction_10329809": { "compartment": "compartment_70101", "id": "reaction_10329809", "reactome": "R-XTR-5603114", "name": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_174390" ], "products": [ "species_111294", "species_29372", "species_71284" ], "modifiers": [ [ "species_10329806", "catalyst" ] ], "additional_components": [ "species_109496", "F6X2C1", "ENSXETT00000002716", "species_74126", "Q566L8", "ENSXETG00000015071" ] }, "reaction_10312209": { "compartment": "compartment_17960", "id": "reaction_10312209", "reactome": "R-XTR-76386", "name": "CYP1A2 S-demethylates 6MMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_76384", "species_113601" ], "products": [ "species_143501", "species_113519", "species_113564", "species_33153" ], "modifiers": [ [ "species_10312204", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10331414": { "compartment": "compartment_5460", "id": "reaction_10331414", "reactome": "R-XTR-5694563", "name": "ABHD10 hydrolyses MPAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694574", "species_113521" ], "products": [ "species_5694569", "species_5694565" ], "modifiers": [ [ "species_10331411", "catalyst" ] ], "additional_components": [ "ENSXETT00000020196" ] }, "reaction_10313610": { "compartment": "compartment_17957", "id": "reaction_10313610", "reactome": "R-XTR-176059", "name": "GST trimers transfer GS from GSH to luminal substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158543", "species_176065" ], "products": [ "species_176048" ], "modifiers": [ [ "species_10313607", "catalyst" ] ], "additional_components": [ "species_156523", "species_38987", "species_76396", "CHEBI:32639", "CHEBI:2505", "CHEBI:35896", "A0A6I8RJ83", "ENSXETG00000036671", "F6PX96", "ENSXETT00000016673", "F6VC96", "ENSXETT00000010309" ] }, "reaction_10331194": { "compartment": "compartment_70101", "id": "reaction_10331194", "reactome": "R-XTR-5692232", "name": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_5692212" ], "products": [ "species_5692216", "species_29364" ], "modifiers": [ [ "species_10330359", "catalyst" ] ], "additional_components": [ "ENSXETT00000007570" ] }, "reaction_10322294": { "compartment": "compartment_70101", "id": "reaction_10322294", "reactome": "R-XTR-1247922", "name": "GGCT transforms gGluCys to OPRO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393" ], "products": [ "species_111707", "species_1247942" ], "modifiers": [ [ "species_10322291", "catalyst" ] ], "additional_components": [ "F6PKI1", "ENSXETT00000047646" ] }, "reaction_10313587": { "compartment": "compartment_70101", "id": "reaction_10313587", "reactome": "R-XTR-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10313584", "catalyst" ] ], "additional_components": [ "species_76396", "CHEBI:34718", "CHEBI:30614", "CHEBI:8927", "CHEBI:32639", "CHEBI:34479", "A0A6I8S817", "ENSXETG00000036388", "F6SJ37", "ENSXETT00000045440", "A0A6I8QYI0", "ENSXETG00000038870" ] }, "reaction_10331421": { "compartment": "compartment_70101", "id": "reaction_10331421", "reactome": "R-XTR-5695964", "name": "ABHD14B hydrolyses PNPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5695960", "species_29356" ], "products": [ "species_5695950", "species_76179" ], "modifiers": [ [ "species_10331418", "catalyst" ] ], "additional_components": [ "ENSXETT00000063063" ] }, "reaction_10336924": { "compartment": "compartment_17963", "id": "reaction_10336924", "reactome": "R-XTR-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8851226", "species_8953493" ], "modifiers": [ [ "species_10336921", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "species_109496", "Q28CL4", "ENSXETT00000012482" ] }, "reaction_10313663": { "compartment": "compartment_70101", "id": "reaction_10313663", "reactome": "R-XTR-176631", "name": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176626" ], "products": [ "species_176496", "species_158466" ], "modifiers": [ [ "species_10313660", "catalyst" ] ], "additional_components": [ "A0A6I8PTM1", "ENSXETG00000033931", "B0BM84", "ENSXETT00000064929" ] }, "reaction_10313656": { "compartment": "compartment_70101", "id": "reaction_10313656", "reactome": "R-XTR-176604", "name": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176565", "species_158471" ], "products": [ "species_176483", "species_158466" ], "modifiers": [ [ "species_10313634", "catalyst" ] ], "additional_components": [ "B0BM84", "ENSXETT00000064929", "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313658": { "compartment": "compartment_70101", "id": "reaction_10313658", "reactome": "R-XTR-176609", "name": "cholesterol + PAPS => cholesterol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_158471" ], "products": [ "species_176618", "species_158466" ], "modifiers": [ [ "species_10313643", "catalyst" ] ], "additional_components": [ "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313654": { "compartment": "compartment_70101", "id": "reaction_10313654", "reactome": "R-XTR-176588", "name": "lithocholate + PAPS => lithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_158471" ], "products": [ "species_176555", "species_158466" ], "modifiers": [ [ "species_10313634", "catalyst" ] ], "additional_components": [ "B0BM84", "ENSXETT00000064929", "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313649": { "compartment": "compartment_70101", "id": "reaction_10313649", "reactome": "R-XTR-176517", "name": "SULTs transfer (SO4)2- group to PREG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_158471" ], "products": [ "species_176665", "species_158466" ], "modifiers": [ [ "species_10313643", "catalyst" ] ], "additional_components": [ "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313651": { "compartment": "compartment_70101", "id": "reaction_10313651", "reactome": "R-XTR-176585", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176667", "species_158471" ], "products": [ "species_176564", "species_158466" ], "modifiers": [ [ "species_10313636", "catalyst" ] ], "additional_components": [ "F6QKH7", "ENSXETT00000042862", "L7N312", "ENSXETT00000017267", "B0BM84", "ENSXETT00000064929", "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313682": { "compartment": "compartment_70101", "id": "reaction_10313682", "reactome": "R-XTR-176669", "name": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176566" ], "products": [ "species_176500", "species_158466" ], "modifiers": [ [ "species_10313679", "catalyst" ] ], "additional_components": [ "F6QKH7", "ENSXETT00000042862", "L7N312", "ENSXETT00000017267" ] }, "reaction_10313677": { "compartment": "compartment_70101", "id": "reaction_10313677", "reactome": "R-XTR-176664", "name": "estrone + PAPS => estrone 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176575", "species_158471" ], "products": [ "species_176501", "species_158466" ], "modifiers": [ [ "species_10313634", "catalyst" ] ], "additional_components": [ "B0BM84", "ENSXETT00000064929", "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313646": { "compartment": "compartment_70101", "id": "reaction_10313646", "reactome": "R-XTR-176494", "name": "SULTs transfer (SO4)2- group to 27HCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176617", "species_158471" ], "products": [ "species_176502", "species_158466" ], "modifiers": [ [ "species_10313643", "catalyst" ] ], "additional_components": [ "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10336939": { "compartment": "compartment_17963", "id": "reaction_10336939", "reactome": "R-XTR-8954262", "name": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336928", "species_741440" ], "products": [ "species_742343", "species_10336932" ], "modifiers": [ [ "species_10336936", "catalyst" ] ], "additional_components": [ "ENSXETG00000039537", "ENSXETG00000039537", "ENSXETG00000017664" ] }, "reaction_10313674": { "compartment": "compartment_70101", "id": "reaction_10313674", "reactome": "R-XTR-176646", "name": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5695950", "species_158471" ], "products": [ "species_176600", "species_158466" ], "modifiers": [ [ "species_10313671", "catalyst" ] ], "additional_components": [ "F6QKH7", "ENSXETT00000042862", "L7N312", "ENSXETT00000017267" ] }, "reaction_10313639": { "compartment": "compartment_70101", "id": "reaction_10313639", "reactome": "R-XTR-176474", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176486" ], "products": [ "species_176519", "species_158466" ], "modifiers": [ [ "species_10313636", "catalyst" ] ], "additional_components": [ "F6QKH7", "ENSXETT00000042862", "L7N312", "ENSXETT00000017267", "B0BM84", "ENSXETT00000064929", "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313039": { "compartment": "compartment_5460", "id": "reaction_10313039", "reactome": "R-XTR-159566", "name": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_159447" ], "products": [ "species_29374", "species_159564" ], "modifiers": [ [ "species_10313036", "catalyst" ] ], "additional_components": [ "A0A6I8RQD3", "ENSXETG00000038499" ] }, "reaction_10313024": { "compartment": "compartment_5460", "id": "reaction_10313024", "reactome": "R-XTR-159443", "name": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_159446" ], "products": [ "species_159448", "species_159450", "species_159447" ], "modifiers": [ [ "species_10313019", "catalyst" ] ], "additional_components": [ "ENSXETT00000036505" ] }, "reaction_10313808": { "compartment": "compartment_5460", "id": "reaction_10313808", "reactome": "R-XTR-177157", "name": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_177153" ], "products": [ "species_159448", "species_159450", "species_177137" ], "modifiers": [ [ "species_10313019", "catalyst" ] ], "additional_components": [ "ENSXETT00000036505" ] }, "reaction_10313045": { "compartment": "compartment_5460", "id": "reaction_10313045", "reactome": "R-XTR-159567", "name": "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_159559" ], "products": [ "species_159448", "species_159450", "species_159557" ], "modifiers": [ [ "species_10313019", "catalyst" ] ], "additional_components": [ "ENSXETT00000036505" ] }, "reaction_10313047": { "compartment": "compartment_5460", "id": "reaction_10313047", "reactome": "R-XTR-159574", "name": "salicylate-CoA + glycine => salicyluric acid + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_159557" ], "products": [ "species_29374", "species_159572" ], "modifiers": [ [ "species_10313036", "catalyst" ] ], "additional_components": [ "A0A6I8RQD3", "ENSXETG00000038499" ] }, "reaction_10332302": { "compartment": "compartment_70101", "id": "reaction_10332302", "reactome": "R-XTR-6786190", "name": "CMBL hydrolyses OM to OLMS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6786175" ], "products": [ "species_6786194", "species_6786179" ], "modifiers": [ [ "species_10332299", "catalyst" ] ], "additional_components": [ "ENSXETT00000054521" ] }, "reaction_10331432": { "compartment": "compartment_5460", "id": "reaction_10331432", "reactome": "R-XTR-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10311857", "catalyst" ] ], "additional_components": [ "A0A6I8RHR6", "ENSXETG00000020930" ] }, "reaction_10311851": { "compartment": "compartment_70101", "id": "reaction_10311851", "reactome": "R-XTR-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_29510", "species_73473" ], "modifiers": [ [ "species_10311848", "catalyst" ] ], "additional_components": [ "A0A6I8RYK1", "ENSXETG00000032351", "species_29426", "F7DZV1", "ENSXETT00000020485", "F6YU63", "ENSXETT00000024409", "A0A6I8PVR9", "ENSXETG00000032433" ] }, "reaction_10331211": { "compartment": "compartment_70101", "id": "reaction_10331211", "reactome": "R-XTR-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_5692249", "species_70106", "species_73473" ], "modifiers": [ [ "species_10331208", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8PVR9", "ENSXETG00000032433", "A0A6I8RYK1", "ENSXETG00000032351", "F6YU63", "ENSXETT00000024409", "F7DZV1", "ENSXETT00000020485" ] }, "reaction_10311860": { "compartment": "compartment_5460", "id": "reaction_10311860", "reactome": "R-XTR-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10311857", "catalyst" ] ], "additional_components": [ "A0A6I8RHR6", "ENSXETG00000020930" ] }, "reaction_10331448": { "compartment": "compartment_984", "id": "reaction_10331448", "reactome": "R-XTR-5696131", "name": "AOC1 deaminates Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_390899", "species_352327" ], "products": [ "species_351626", "species_2022135", "species_351629", "species_5696128" ], "modifiers": [ [ "species_10331445", "catalyst" ] ], "additional_components": [ "species_74112", "CHEBI:28694", "A0A6I8R549", "ENSXETG00000011988" ] }, "reaction_10316604": { "compartment": "compartment_17960", "id": "reaction_10316604", "reactome": "R-XTR-217258", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_217315" ], "products": [ "species_113519", "species_113564", "species_217320" ], "modifiers": [ [ "species_10316601", "catalyst" ] ], "additional_components": [ "species_109496", "species_113596", "A0A6I8RVH1", "ENSXETG00000009900", "A0A6I8R1H4", "ENSXETG00000025145" ] }, "reaction_10312825": { "compartment": "compartment_17957", "id": "reaction_10312825", "reactome": "R-XTR-139970", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30373", "species_113601" ], "products": [ "species_113519", "species_113564", "species_140963" ], "modifiers": [ [ "species_10312822", "catalyst" ] ], "additional_components": [ "species_113596", "A0A6I8Q243", "ENSXETG00000025142" ] }, "reaction_10316593": { "compartment": "compartment_17960", "id": "reaction_10316593", "reactome": "R-XTR-217255", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_159154" ], "products": [ "species_113519", "species_113564", "species_217269" ], "modifiers": [ [ "species_10316590", "catalyst" ] ], "additional_components": [ "A0A6I8RVH1", "ENSXETG00000009900", "A0A6I8R1H4", "ENSXETG00000025145", "species_113596" ] }, "reaction_10312236": { "compartment": "compartment_12045", "id": "reaction_10312236", "reactome": "R-XTR-76496", "name": "PTGIS, CYP8A1 isomerise PGH2 to PGI2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30138" ], "products": [ "species_31593" ], "modifiers": [ [ "species_10312233", "catalyst" ] ], "additional_components": [ "ENSXETG00000001780" ] }, "reaction_10316443": { "compartment": "compartment_12045", "id": "reaction_10316443", "reactome": "R-XTR-212007", "name": "CYP26A1,B1 4-hydroxylate atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_215573", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215584" ], "modifiers": [ [ "species_10316440", "catalyst" ] ], "additional_components": [ "ENSXETG00000021546" ] }, "reaction_10316086": { "compartment": "compartment_70101", "id": "reaction_10316086", "reactome": "R-XTR-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_8963870", "species_29364" ], "products": [ "species_8963879", "species_29356", "species_29366" ], "modifiers": [ [ "species_10316083", "catalyst" ] ], "additional_components": [ "ENSXETT00000021283" ] }, "reaction_10312222": { "compartment": "compartment_12045", "id": "reaction_10312222", "reactome": "R-XTR-76453", "name": "Coumarin is 7-hydroxylated by CYP2A6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_76328", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76452" ], "modifiers": [ [ "species_10312219", "catalyst" ] ], "additional_components": [ "A0A6I8T1P2", "ENSXETG00000027556" ] }, "reaction_10316377": { "compartment": "compartment_12045", "id": "reaction_10316377", "reactome": "R-XTR-211948", "name": "CYP3A4 can N-demethylate loperamide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_213155" ], "products": [ "species_113519", "species_113564", "species_213151" ], "modifiers": [ [ "species_10316374", "catalyst" ] ], "additional_components": [ "F7B981", "ENSXETT00000026362", "A0A6I8Q6H5", "ENSXETT00000026362" ] }, "reaction_10316372": { "compartment": "compartment_12045", "id": "reaction_10316372", "reactome": "R-XTR-211929", "name": "CYP2C19 5-hydroxylates omeprazole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211892", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211944" ], "modifiers": [ [ "species_10316367", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10316436": { "compartment": "compartment_12045", "id": "reaction_10316436", "reactome": "R-XTR-212005", "name": "CYP2F1 dehydrogenates 3-methylindole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_213162", "species_113601" ], "products": [ "species_113519", "species_113564", "species_213163" ], "modifiers": [ [ "species_10316433", "catalyst" ] ], "additional_components": [ "A0A6I8QHP5", "ENSXETG00000035878" ] }, "reaction_10316564": { "compartment": "compartment_12045", "id": "reaction_10316564", "reactome": "R-XTR-213175", "name": "CYP3A4,5 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_156522", "species_113601" ], "products": [ "species_113519", "species_113564", "species_156523" ], "modifiers": [ [ "species_10316561", "catalyst" ] ], "additional_components": [ "A0A6I8Q6H5", "ENSXETT00000026362", "F7B981", "ENSXETT00000026362" ] }, "reaction_10316370": { "compartment": "compartment_12045", "id": "reaction_10316370", "reactome": "R-XTR-211910", "name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211906", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211894" ], "modifiers": [ [ "species_10316367", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10316365": { "compartment": "compartment_12045", "id": "reaction_10316365", "reactome": "R-XTR-211882", "name": "CYP3A7 can 6beta-hydroxylate testosterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30321", "species_113601" ], "products": [ "species_113519", "species_113564", "species_213144" ], "modifiers": [ [ "species_10316362", "catalyst" ] ], "additional_components": [ "A0A6I8Q6H5", "ENSXETT00000026362", "F7B981", "ENSXETT00000026362" ] }, "reaction_10316431": { "compartment": "compartment_12045", "id": "reaction_10316431", "reactome": "R-XTR-212004", "name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_211939" ], "products": [ "species_113519", "species_113564", "species_211927" ], "modifiers": [ [ "species_10316428", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312207": { "compartment": "compartment_17960", "id": "reaction_10312207", "reactome": "R-XTR-76373", "name": "N-hydroxylation of 4-aminobiphenyl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_47687", "species_113601" ], "products": [ "species_113519", "species_113564", "species_34889" ], "modifiers": [ [ "species_10312204", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10312215": { "compartment": "compartment_17960", "id": "reaction_10312215", "reactome": "R-XTR-76426", "name": "N-atom dealkylation of caffeine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_40727", "species_113601" ], "products": [ "species_143501", "species_113519", "species_113564", "species_76424" ], "modifiers": [ [ "species_10312204", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10316426": { "compartment": "compartment_12045", "id": "reaction_10316426", "reactome": "R-XTR-211991", "name": "Cyclophosphamide is 4-hydroxylated by CYP2B6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211977", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211967" ], "modifiers": [ [ "species_10316423", "catalyst" ] ], "additional_components": [ "A0A6I8QHP5", "ENSXETG00000035878" ] }, "reaction_10316421": { "compartment": "compartment_12045", "id": "reaction_10316421", "reactome": "R-XTR-211988", "name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211855", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211937" ], "modifiers": [ [ "species_10316367", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312227": { "compartment": "compartment_12045", "id": "reaction_10312227", "reactome": "R-XTR-76472", "name": "Ethylene is oxidized to Ethylene oxide by CYP1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_38985", "species_113601" ], "products": [ "species_113519", "species_113564", "species_38987" ], "modifiers": [ [ "species_10312224", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10312217": { "compartment": "compartment_17960", "id": "reaction_10312217", "reactome": "R-XTR-76434", "name": "Dehalogenation of carbon tetrachloride to form a free radical", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40887" ], "products": [ "species_29572", "species_76433" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312200": { "compartment": "compartment_17960", "id": "reaction_10312200", "reactome": "R-XTR-76354", "name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_39417", "species_113601" ], "products": [ "species_156524", "species_113519", "species_113564" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312213": { "compartment": "compartment_17960", "id": "reaction_10312213", "reactome": "R-XTR-76416", "name": "Benzene is hydroxylated to phenol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_31711", "species_156540", "species_113601" ], "products": [ "species_113519", "species_29630", "species_113564" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312229": { "compartment": "compartment_17960", "id": "reaction_10312229", "reactome": "R-XTR-76475", "name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_40795", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76474", "species_76473" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312881": { "compartment": "compartment_17957", "id": "reaction_10312881", "reactome": "R-XTR-143468", "name": "MEOS oxidizes ethanol to acetaldehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113748", "species_113601" ], "products": [ "species_113519", "species_113564", "species_113745" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312211": { "compartment": "compartment_17957", "id": "reaction_10312211", "reactome": "R-XTR-76397", "name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_113564", "species_39427", "species_113555" ], "products": [ "species_113519", "species_76396", "species_113601" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10316354": { "compartment": "compartment_12045", "id": "reaction_10316354", "reactome": "R-XTR-211881", "name": "Coumarin is 7-hydroxylated by CYP2A13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_76328", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76452" ], "modifiers": [ [ "species_10316351", "catalyst" ] ], "additional_components": [ "F6SM60", "ENSXETT00000031981", "A0A6I8RC71", "ENSXETG00000024858", "A0A6I8Q180", "ENSXETG00000027561", "A0A6I8T1P2", "ENSXETG00000027556", "F6XRS5", "ENSXETT00000042326" ] }, "reaction_10316349": { "compartment": "compartment_17960", "id": "reaction_10316349", "reactome": "R-XTR-211874", "name": "CYP2S1 4-hydroxylates atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_215573", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215584" ], "modifiers": [ [ "species_10312173", "catalyst" ] ], "additional_components": [ "ENSXETG00000035878" ] }, "reaction_10316394": { "compartment": "compartment_17960", "id": "reaction_10316394", "reactome": "R-XTR-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_216620", "species_113519", "species_113564" ], "modifiers": [ [ "species_10316391", "catalyst" ] ], "additional_components": [ "ENSXETT00000042586" ] }, "reaction_10316419": { "compartment": "compartment_17960", "id": "reaction_10316419", "reactome": "R-XTR-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_216547" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10316416", "catalyst" ] ], "additional_components": [ "A0A6I8PZZ5", "ENSXETG00000034285", "F7AA19", "ENSXETT00000010485", "A0A6I8S3Z7", "ENSXETG00000034657", "A0A6I8QTX8", "ENSXETT00000010485", "A0A6I8Q285", "ENSXETG00000031264" ] }, "reaction_10316387": { "compartment": "compartment_17960", "id": "reaction_10316387", "reactome": "R-XTR-211959", "name": "CYP3A43 6b-hydroxylates TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30321", "species_113601" ], "products": [ "species_113519", "species_113564", "species_213144" ], "modifiers": [ [ "species_10316360", "catalyst" ] ], "additional_components": [ "A0A6I8Q6H5", "ENSXETT00000026362", "F7B981", "ENSXETT00000026362" ] }, "reaction_10314222": { "compartment": "compartment_70101", "id": "reaction_10314222", "reactome": "R-XTR-192061", "name": "CYP46A1 24-hydroxylates CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193384", "species_29368", "species_29364" ], "products": [ "species_192060", "species_29356", "species_29366" ], "modifiers": [ [ "species_10314219", "catalyst" ] ], "additional_components": [ "ENSXETG00000032861" ] }, "reaction_10314297": { "compartment": "compartment_5460", "id": "reaction_10314297", "reactome": "R-XTR-193997", "name": "CYP11B1 oxidises 11DCORT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_193998", "species_113529", "species_113600" ], "products": [ "species_113563", "species_194011", "species_113521" ], "modifiers": [ [ "species_10314289", "catalyst" ] ], "additional_components": [ "ENSXETG00000037871" ] }, "reaction_10314299": { "compartment": "compartment_5460", "id": "reaction_10314299", "reactome": "R-XTR-194017", "name": "CYP11B2 oxidises 11DCORST to CORST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_193988", "species_113600" ], "products": [ "species_113563", "species_194005", "species_113521" ], "modifiers": [ [ "species_10314289", "catalyst" ] ], "additional_components": [ "ENSXETG00000037871" ] }, "reaction_10314292": { "compartment": "compartment_5460", "id": "reaction_10314292", "reactome": "R-XTR-193965", "name": "CYP11B2 oxidises 18HCORST to ALDO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194012", "species_113533", "species_113529", "species_113600" ], "products": [ "species_193982", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314289", "catalyst" ] ], "additional_components": [ "ENSXETG00000037871" ] }, "reaction_10314294": { "compartment": "compartment_5460", "id": "reaction_10314294", "reactome": "R-XTR-193995", "name": "CYP11B2 18-hydroxylates CORST to 18HCORST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_194005", "species_113600" ], "products": [ "species_194012", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314289", "catalyst" ] ], "additional_components": [ "ENSXETG00000037871" ] }, "reaction_10316384": { "compartment": "compartment_70101", "id": "reaction_10316384", "reactome": "R-XTR-211951", "name": "CYP1B1 4-hydroxylates EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193132", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_211973" ], "modifiers": [ [ "species_10316381", "catalyst" ] ], "additional_components": [ "ENSXETG00000038590" ] }, "reaction_10314224": { "compartment": "compartment_5460", "id": "reaction_10314224", "reactome": "R-XTR-192123", "name": "CYP27A1 27-hydroxylates CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_193840", "species_113600" ], "products": [ "species_113563", "species_193846", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10331223": { "compartment": "compartment_70101", "id": "reaction_10331223", "reactome": "R-XTR-5692283", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692409", "species_29356", "species_29366" ], "products": [ "species_70106", "species_5692433", "species_29364" ], "modifiers": [ [ "species_10331220", "catalyst" ] ], "additional_components": [ "ENSXETT00000029530" ] }, "reaction_10331315": { "compartment": "compartment_17957", "id": "reaction_10331315", "reactome": "R-XTR-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_156540", "species_5693711", "species_5693712" ], "modifiers": [ [ "species_10331312", "catalyst" ] ], "additional_components": [ "A0A6I8Q0V4", "ENSXETG00000030902", "A0A5G3JDL4", "ENSXETT00000103127" ] }, "reaction_10336179": { "compartment": "compartment_70101", "id": "reaction_10336179", "reactome": "R-XTR-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10336176", "catalyst" ] ], "additional_components": [ "A0A5G3JDL4", "ENSXETT00000103127", "A0A6I8Q0V4", "ENSXETG00000030902" ] }, "reaction_10336114": { "compartment": "compartment_70101", "id": "reaction_10336114", "reactome": "R-XTR-8936442", "name": "MARC1,MARC2 reduce N-hydroxylated compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_8936443", "species_73473" ], "products": [ "species_29356", "species_29468", "species_29360" ], "modifiers": [ [ "species_10336111", "catalyst" ] ], "additional_components": [ "A0A1B8Y4Y6", "ENSXETT00000087008", "CHEBI:21437", "F6WBG7", "ENSXETT00000038708" ] }, "reaction_10329678": { "compartment": "compartment_70101", "id": "reaction_10329678", "reactome": "R-XTR-5423672", "name": "CYP1A2, 3A4 oxidise AFB1 to AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_5423605", "species_29364" ], "products": [ "species_5423663", "species_29356", "species_29366" ], "modifiers": [ [ "species_10329675", "catalyst" ] ], "additional_components": [ "A4IGV4", "ENSXETT00000061279", "F7B981", "ENSXETT00000026362", "A0A6I8Q6H5", "ENSXETT00000026362" ] }, "reaction_10329673": { "compartment": "compartment_70101", "id": "reaction_10329673", "reactome": "R-XTR-5423664", "name": "CYP3A4,5 hydroxylates AFB1 to AFQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_5423605", "species_29364" ], "products": [ "species_5423660", "species_29356", "species_29366" ], "modifiers": [ [ "species_10329670", "catalyst" ] ], "additional_components": [ "F7B981", "ENSXETT00000026362", "A0A6I8Q6H5", "ENSXETT00000026362" ] }, "reaction_10329707": { "compartment": "compartment_70101", "id": "reaction_10329707", "reactome": "R-XTR-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_2022890", "species_5490231" ], "modifiers": [ [ "species_10329704", "catalyst" ] ], "additional_components": [ "CHEBI:78580", "CHEBI:78585", "CHEBI:78583", "CHEBI:78578", "species_29426", "A0A6I8PUM5", "ENSXETG00000032120" ] }, "reaction_10329668": { "compartment": "compartment_70101", "id": "reaction_10329668", "reactome": "R-XTR-5423653", "name": "MGST trimers transfer GS from GSH to AFXBO and AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5423723" ], "products": [ "species_5423730" ], "modifiers": [ [ "species_10313607", "catalyst" ] ], "additional_components": [ "species_156523", "species_5423663", "CHEBI:78581", "CHEBI:78587", "A0A6I8RJ83", "ENSXETG00000036671", "F6PX96", "ENSXETT00000016673", "F6VC96", "ENSXETT00000010309" ] }, "reaction_10312902": { "compartment": "compartment_70101", "id": "reaction_10312902", "reactome": "R-XTR-156526", "name": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_5423605", "species_29364" ], "products": [ "species_29356", "species_159211", "species_29366" ], "modifiers": [ [ "species_10312899", "catalyst" ] ], "additional_components": [ "A4IGV4", "ENSXETT00000061279", "F7B981", "ENSXETT00000026362", "A0A6I8Q6H5", "ENSXETT00000026362", "F6SM60", "ENSXETT00000031981", "A0A6I8RC71", "ENSXETG00000024858", "A0A6I8Q180", "ENSXETG00000027561", "A0A6I8T1P2", "ENSXETG00000027556", "F6XRS5", "ENSXETT00000042326" ] }, "reaction_10337910": { "compartment": "compartment_70101", "id": "reaction_10337910", "reactome": "R-XTR-9638046", "name": "ACY3:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_2022890", "species_5490231" ], "modifiers": [ [ "species_10337907", "catalyst" ] ], "additional_components": [ "CHEBI:78580", "CHEBI:78585", "CHEBI:78583", "CHEBI:78578", "species_29426", "Q5BJ91", "ENSXETT00000019664" ] }, "reaction_10329680": { "compartment": "compartment_12045", "id": "reaction_10329680", "reactome": "R-XTR-5423678", "name": "CYP1A2 hydroxylates AFB1 to AFM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_5423605", "species_29364" ], "products": [ "species_5423629", "species_29356", "species_29366" ], "modifiers": [ [ "species_10312204", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10329666": { "compartment": "compartment_70101", "id": "reaction_10329666", "reactome": "R-XTR-5423647", "name": "CYP2A13 oxidises AFM1 to AFM1E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5423629", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_5423657", "species_29366" ], "modifiers": [ [ "species_10312195", "catalyst" ] ], "additional_components": [ "F6SM60", "ENSXETT00000031981", "A0A6I8RC71", "ENSXETG00000024858", "A0A6I8Q180", "ENSXETG00000027561", "A0A6I8T1P2", "ENSXETG00000027556", "F6XRS5", "ENSXETT00000042326" ] }, "reaction_10315625": { "compartment": "compartment_876", "id": "reaction_10315625", "reactome": "R-XTR-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10315622", "catalyst" ] ], "additional_components": [ "A0A6I8PTQ0", "ENSXETG00000014772", "F6TI71", "ENSXETT00000005158" ] }, "reaction_10314029": { "compartment": "compartment_7660", "id": "reaction_10314029", "reactome": "R-XTR-187937", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314001", "species_10314025" ], "products": [ "species_10314027" ], "modifiers": [], "additional_components": [ "F6T0J1", "ENSXETT00000046130", "ENSXETG00000000021", "A0A6I8QJI3", "ENSXETG00000000021", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10314040": { "compartment": "compartment_7660", "id": "reaction_10314040", "reactome": "R-XTR-187959", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10314027" ], "products": [ "species_113582", "species_10314037" ], "modifiers": [ [ "species_10314027", "catalyst" ] ], "additional_components": [ "A0A6I8QJI3", "ENSXETG00000000021", "F6T0J1", "ENSXETT00000046130", "F6T0J1", "ENSXETT00000046130", "A0A6I8QJI3", "ENSXETG00000000021", "A0A6I8QJI3", "ENSXETG00000000021", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10327234": { "compartment": "compartment_70101", "id": "reaction_10327234", "reactome": "R-XTR-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327232" ], "products": [ "species_10313135" ], "modifiers": [], "additional_components": [ "ENSXETT00000022754", "ENSXETT00000022754" ] }, "reaction_10328464": { "compartment": "compartment_7660", "id": "reaction_10328464", "reactome": "R-XTR-4088024", "name": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10328459" ], "products": [ "species_113582", "species_10328462" ], "modifiers": [ [ "species_10314001", "catalyst" ] ], "additional_components": [ "ENSXETG00000035621", "ENSXETG00000035621", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10335127": { "compartment": "compartment_70101", "id": "reaction_10335127", "reactome": "R-XTR-8852331", "name": "GTSE1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335118" ], "products": [ "species_10335125" ], "modifiers": [], "additional_components": [ "ENSXETT00000061292", "ENSXETT00000061292" ] }, "reaction_10335121": { "compartment": "compartment_70101", "id": "reaction_10335121", "reactome": "R-XTR-8852317", "name": "PLK1 phosphorylates GTSE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10335115" ], "products": [ "species_10327232", "species_29370", "species_10335118" ], "modifiers": [ [ "species_10335115", "catalyst" ] ], "additional_components": [ "Q28DF6", "ENSXETT00000061292", "P62205", "ENSXETT00000022754", "ENSXETT00000022754", "ENSXETT00000061292", "Q28DF6", "ENSXETT00000061292", "P62205", "ENSXETT00000022754" ] }, "reaction_10335123": { "compartment": "compartment_70101", "id": "reaction_10335123", "reactome": "R-XTR-8852324", "name": "GTSE1 binds PLK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327232", "species_10335113" ], "products": [ "species_10335115" ], "modifiers": [], "additional_components": [ "ENSXETT00000022754", "ENSXETT00000061292", "Q28DF6", "ENSXETT00000061292", "P62205", "ENSXETT00000022754" ] }, "reaction_10328475": { "compartment": "compartment_7660", "id": "reaction_10328475", "reactome": "R-XTR-4088134", "name": "PLK1 phosphorylates FOXM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328466", "species_29358" ], "products": [ "species_113582", "species_10328472", "species_10313135" ], "modifiers": [ [ "species_10328466", "catalyst" ] ], "additional_components": [ "P62205", "ENSXETT00000022754", "A0A6I8RBK3", "ENSXETG00000035621", "ENSXETG00000035621", "ENSXETT00000022754", "P62205", "ENSXETT00000022754", "A0A6I8RBK3", "ENSXETG00000035621" ] }, "reaction_10328468": { "compartment": "compartment_7660", "id": "reaction_10328468", "reactome": "R-XTR-4088130", "name": "PLK1 binds FOXM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328462", "species_10313135" ], "products": [ "species_10328466" ], "modifiers": [], "additional_components": [ "ENSXETG00000035621", "ENSXETT00000022754", "P62205", "ENSXETT00000022754", "A0A6I8RBK3", "ENSXETG00000035621" ] }, "reaction_10324271": { "compartment": "compartment_70101", "id": "reaction_10324271", "reactome": "R-XTR-1855216", "name": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_29370", "species_1629740" ], "modifiers": [ [ "species_10324253", "catalyst" ] ], "additional_components": [ "ENSXETT00000018584" ] }, "reaction_10324302": { "compartment": "compartment_70101", "id": "reaction_10324302", "reactome": "R-XTR-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_1629765", "species_29370" ], "modifiers": [ [ "species_10324235", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324296": { "compartment": "compartment_70101", "id": "reaction_10324296", "reactome": "R-XTR-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10324235", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324262": { "compartment": "compartment_70101", "id": "reaction_10324262", "reactome": "R-XTR-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10324235", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324240": { "compartment": "compartment_70101", "id": "reaction_10324240", "reactome": "R-XTR-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10324235", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324256": { "compartment": "compartment_70101", "id": "reaction_10324256", "reactome": "R-XTR-1855182", "name": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10324253", "catalyst" ] ], "additional_components": [ "ENSXETT00000018584" ] }, "reaction_10324259": { "compartment": "compartment_70101", "id": "reaction_10324259", "reactome": "R-XTR-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10324235", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10331934": { "compartment": "compartment_70101", "id": "reaction_10331934", "reactome": "R-XTR-5696627", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10331927" ], "products": [ "species_10331931", "species_10313391" ], "modifiers": [ [ "species_10331927", "catalyst" ] ], "additional_components": [ "A0A6I8SGS6", "ENSXETG00000031250", "A0A6I8RKP9", "ENSXETG00000031817", "Q28DL4", "ENSXETG00000007549", "A0A6I8RKP9", "ENSXETG00000031817", "Q28DL4", "ENSXETG00000007549", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8SGS6", "ENSXETG00000031250", "A0A6I8RKP9", "ENSXETG00000031817", "Q28DL4", "ENSXETG00000007549" ] }, "reaction_10320632": { "compartment": "compartment_70101", "id": "reaction_10320632", "reactome": "R-XTR-936390", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320623" ], "products": [ "species_10320625", "species_10312116" ], "modifiers": [ [ "species_10320629", "catalyst" ] ], "additional_components": [ "ENSXETG00000009200", "ENSXETG00000009200", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "ENSXETG00000031250" ] }, "reaction_10331914": { "compartment": "compartment_7660", "id": "reaction_10331914", "reactome": "R-XTR-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10331767" ], "products": [ "species_10331911", "species_10331769" ], "modifiers": [ [ "species_10331767", "catalyst" ] ], "additional_components": [ "A0A6I8RK73", "ENSXETG00000005089", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8RK73", "ENSXETG00000005089", "A0A6I8RK73", "ENSXETG00000005089" ] }, "reaction_10332196": { "compartment": "compartment_17906", "id": "reaction_10332196", "reactome": "R-XTR-5696872", "name": "USP30 deubiquitinates Ub-MOM proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10331979" ], "products": [ "species_10332193", "species_10331995" ], "modifiers": [ [ "species_10331979", "catalyst" ] ], "additional_components": [ "Q6DFM9", "ENSXETT00000098526", "A4QNN3", "ENSXETT00000048254", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q6DFM9", "ENSXETT00000098526", "A4QNN3", "ENSXETT00000048254", "Q6DFM9", "ENSXETT00000098526", "A4QNN3", "ENSXETT00000048254" ] }, "reaction_10330999": { "compartment": "compartment_7660", "id": "reaction_10330999", "reactome": "R-XTR-5690157", "name": "USP16,USP21 deubiquitinate Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10330994" ], "products": [ "species_10327687", "species_10330996" ], "modifiers": [ [ "species_10330994", "catalyst" ] ], "additional_components": [ "Q0VA64", "ENSXETG00000020255", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q0VA64", "ENSXETG00000020255", "Q0VA64", "ENSXETG00000020255" ] }, "reaction_10332214": { "compartment": "compartment_7660", "id": "reaction_10332214", "reactome": "R-XTR-5696997", "name": "USP24 deubiquitinates DDB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10332207" ], "products": [ "species_10332211", "species_10331911" ], "modifiers": [ [ "species_10332207", "catalyst" ] ], "additional_components": [ "Q66JG1", "ENSXETT00000008619", "A0A6I8SCT2", "ENSXETG00000009543", "A0A6I8SCT2", "ENSXETG00000009543", "Q66JG1", "ENSXETT00000008619", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q66JG1", "ENSXETT00000008619", "A0A6I8SCT2", "ENSXETG00000009543" ] }, "reaction_10331760": { "compartment": "compartment_70101", "id": "reaction_10331760", "reactome": "R-XTR-5696600", "name": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10331549" ], "products": [ "species_10331555", "species_10331757" ], "modifiers": [ [ "species_10331549", "catalyst" ] ], "additional_components": [ "F7BNK9", "ENSXETT00000015033", "A0A6I8SFY9", "ENSXETG00000009200", "B7ZT68", "ENSXETT00000056088", "F7BNK9", "ENSXETT00000015033", "B7ZT68", "ENSXETT00000056088", "A0A6I8SFY9", "ENSXETG00000009200", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7BNK9", "ENSXETT00000015033", "A0A6I8SFY9", "ENSXETG00000009200", "B7ZT68", "ENSXETT00000056088" ] }, "reaction_10331173": { "compartment": "compartment_70101", "id": "reaction_10331173", "reactome": "R-XTR-5691439", "name": "BRISC complex deubiquitinates NLRP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10331164" ], "products": [ "species_10331168", "species_10313391" ], "modifiers": [ [ "species_10331164", "catalyst" ] ], "additional_components": [ "Q5M8J0", "ENSXETG00000025571", "Q4VA72", "ENSXETG00000026184", "Q6P4W0", "ENSXETG00000023627", "Q6DJ78", "ENSXETG00000010201", "Q5M8J0", "ENSXETG00000025571", "Q4VA72", "ENSXETG00000026184", "Q6P4W0", "ENSXETG00000023627", "Q6DJ78", "ENSXETG00000010201", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q5M8J0", "ENSXETG00000025571", "Q4VA72", "ENSXETG00000026184", "Q6P4W0", "ENSXETG00000023627", "Q6DJ78", "ENSXETG00000010201" ] }, "reaction_10331071": { "compartment": "compartment_7660", "id": "reaction_10331071", "reactome": "R-XTR-5690759", "name": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10331006" ], "products": [ "species_10331010", "species_10331068" ], "modifiers": [ [ "species_10331006", "catalyst" ] ], "additional_components": [ "A0A6I8QTP5", "ENSXETG00000014251", "Q66JB6", "ENSXETG00000000091", "Q66JB6", "ENSXETG00000000091", "A0A6I8QTP5", "ENSXETG00000014251", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8QTP5", "ENSXETG00000014251", "Q66JB6", "ENSXETG00000000091" ] }, "reaction_10331073": { "compartment": "compartment_7660", "id": "reaction_10331073", "reactome": "R-XTR-5690785", "name": "BAP1 binds Ub-HCFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330919", "species_10331004" ], "products": [ "species_10331006" ], "modifiers": [], "additional_components": [ "ENSXETG00000000091", "ENSXETG00000014251", "A0A6I8QTP5", "ENSXETG00000014251", "Q66JB6", "ENSXETG00000000091" ] }, "reaction_10335867": { "compartment": "compartment_70101", "id": "reaction_10335867", "reactome": "R-XTR-8869506", "name": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10335864" ], "products": [ "species_10331090", "species_10313391" ], "modifiers": [ [ "species_10335864", "catalyst" ] ], "additional_components": [ "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765", "Q28DL4", "ENSXETG00000007549", "Q28DL4", "ENSXETG00000007549", "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765", "Q28DL4", "ENSXETG00000007549" ] }, "reaction_10331093": { "compartment": "compartment_70101", "id": "reaction_10331093", "reactome": "R-XTR-5690870", "name": "OTUD7B,TNFAIP3 deubiquitinate TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331088", "species_29356" ], "products": [ "species_10331090", "species_10330519" ], "modifiers": [ [ "species_10331088", "catalyst" ] ], "additional_components": [ "Q28DL4", "ENSXETG00000007549", "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765", "Q28DL4", "ENSXETG00000007549", "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q28DL4", "ENSXETG00000007549", "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765" ] }, "reaction_10330909": { "compartment": "compartment_70101", "id": "reaction_10330909", "reactome": "R-XTR-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10313391" ], "products": [ "species_10313391", "species_10313389" ], "modifiers": [ [ "species_10330906", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "ENSXETT00000006019" ] }, "reaction_10325869": { "compartment": "compartment_70101", "id": "reaction_10325869", "reactome": "R-XTR-2038398", "name": "KIBRA (WWC1) binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325797", "species_10325865" ], "products": [ "species_10325867" ], "modifiers": [], "additional_components": [ "ENSXETT00000026288", "ENSXETG00000016462", "A4IIJ3", "ENSXETG00000016462", "F6U2R0", "ENSXETT00000026288" ] }, "reaction_10325851": { "compartment": "compartment_70101", "id": "reaction_10325851", "reactome": "R-XTR-2032770", "name": "Translocation of YAP1 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325815" ], "products": [ "species_10325849" ], "modifiers": [], "additional_components": [ "ENSXETG00000032689", "ENSXETG00000032689" ] }, "reaction_10325835": { "compartment": "compartment_70101", "id": "reaction_10325835", "reactome": "R-XTR-2028644", "name": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312802", "species_10325818" ], "products": [ "species_10325833" ], "modifiers": [], "additional_components": [ "Q5XGC8", "ENSXETG00000022830", "ENSXETG00000032689", "A0A6I8SYU4", "ENSXETG00000032689", "Q5XGC8", "ENSXETG00000022830" ] }, "reaction_10325829": { "compartment": "compartment_70101", "id": "reaction_10325829", "reactome": "R-XTR-2028626", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325797", "species_10325803" ], "products": [ "species_10325805" ], "modifiers": [], "additional_components": [ "ENSXETT00000026288", "ENSXETT00000073958", "Q28FB5", "ENSXETT00000073958", "F6U2R0", "ENSXETT00000026288" ] }, "reaction_10325942": { "compartment": "compartment_70101", "id": "reaction_10325942", "reactome": "R-XTR-2059926", "name": "NPHP4 protein binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325938", "species_10325797" ], "products": [ "species_10325940" ], "modifiers": [], "additional_components": [ "ENSXETG00000002886", "ENSXETT00000026288", "F6U2R0", "ENSXETT00000026288", "A0A6I8SDY8", "ENSXETG00000002886" ] }, "reaction_10325843": { "compartment": "compartment_70101", "id": "reaction_10325843", "reactome": "R-XTR-2028724", "name": "AMOT proteins bind YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325815", "species_10325839" ], "products": [ "species_10325841" ], "modifiers": [], "additional_components": [ "ENSXETG00000032689", "ENSXETG00000006385", "A0A6I8SVS3", "ENSXETG00000006385", "A0A6I8SYU4", "ENSXETG00000032689" ] }, "reaction_10325827": { "compartment": "compartment_70101", "id": "reaction_10325827", "reactome": "R-XTR-2028598", "name": "Phosphorylation of YAP by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325815", "species_113592" ], "products": [ "species_10325824", "species_29370" ], "modifiers": [ [ "species_10325811", "catalyst" ] ], "additional_components": [ "ENSXETG00000032689", "ENSXETG00000032689", "Q28FB5", "ENSXETT00000073958", "F6U2R0", "ENSXETT00000026288" ] }, "reaction_10335596": { "compartment": "compartment_876", "id": "reaction_10335596", "reactome": "R-XTR-8858498", "name": "SL (surrogate light chain) binds IgH to form pre-BCR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335536", "species_10335592" ], "products": [ "species_10335594" ], "modifiers": [], "additional_components": [ "A0A6I8QLS0", "ENSXETG00000041230", "A0A6I8QM25", "ENSXETG00000041230", "A0A6I8PTS9", "ENSXETG00000041230", "A0A6I8RSN1", "ENSXETG00000041230", "A0A6I8PUH7", "ENSXETG00000041230", "A0A6I8S9Z8", "ENSXETG00000041230", "A0A6I8PM56", "ENSXETG00000041230", "A0A6I8RJH0", "ENSXETG00000041230", "A0A6I8PMK7", "ENSXETG00000041230", "A0A6I8RS78", "ENSXETG00000041230", "A0A6I8R4R2", "ENSXETG00000041230", "A0A6I8R767", "ENSXETG00000041230", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8RSK9", "ENSXETG00000040383", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8QKP4", "ENSXETG00000040212", "A0A6I8SYV6", "ENSXETG00000040212", "A0A6I8RUJ4", "ENSXETG00000040212", "A0A6I8SK71", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8RNX1", "ENSXETG00000040212", "A0A6I8QZL1", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212", "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8R2R2", "ENSXETG00000039428", "A0A6I8RZZ7", "ENSXETG00000039428", "A0A6I8QD99", "ENSXETG00000039428", "A0A6I8QNA7", "ENSXETG00000039428", "A0A6I8Q2V3", "ENSXETG00000039428", "A0A6I8Q7C1", "ENSXETG00000039428", "A0A6I8SEP6", "ENSXETG00000039428", "A0A6I8PSU3", "ENSXETG00000039428", "F6S2S6", "ENSXETT00000022997", "A0A6I8QGS1", "ENSXETG00000040831", "A0A6I8SZD5", "ENSXETG00000034688", "A0A6I8QDF6", "ENSXETG00000037057", "A0A6I8S531", "ENSXETG00000040831", "A0A6I8Q881", "ENSXETG00000040831", "A0A6I8RG89", "ENSXETG00000040831", "A0A6I8R6G0", "ENSXETG00000040853", "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8R2R2", "ENSXETG00000039428", "A0A6I8RZZ7", "ENSXETG00000039428", "A0A6I8QD99", "ENSXETG00000039428", "A0A6I8QNA7", "ENSXETG00000039428", "A0A6I8Q2V3", "ENSXETG00000039428", "A0A6I8Q7C1", "ENSXETG00000039428", "A0A6I8SEP6", "ENSXETG00000039428", "A0A6I8PSU3", "ENSXETG00000039428", "F6S2S6", "ENSXETT00000022997", "A0A6I8QGS1", "ENSXETG00000040831", "A0A6I8SZD5", "ENSXETG00000034688", "A0A6I8QDF6", "ENSXETG00000037057", "A0A6I8S531", "ENSXETG00000040831", "A0A6I8Q881", "ENSXETG00000040831", "A0A6I8RG89", "ENSXETG00000040831", "A0A6I8R6G0", "ENSXETG00000040853", "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8QLS0", "ENSXETG00000041230", "A0A6I8QM25", "ENSXETG00000041230", "A0A6I8PTS9", "ENSXETG00000041230", "A0A6I8RSN1", "ENSXETG00000041230", "A0A6I8PUH7", "ENSXETG00000041230", "A0A6I8S9Z8", "ENSXETG00000041230", "A0A6I8PM56", "ENSXETG00000041230", "A0A6I8RJH0", "ENSXETG00000041230", "A0A6I8PMK7", "ENSXETG00000041230", "A0A6I8RS78", "ENSXETG00000041230", "A0A6I8R4R2", "ENSXETG00000041230", "A0A6I8R767", "ENSXETG00000041230", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8RSK9", "ENSXETG00000040383", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8QKP4", "ENSXETG00000040212", "A0A6I8SYV6", "ENSXETG00000040212", "A0A6I8RUJ4", "ENSXETG00000040212", "A0A6I8SK71", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8RNX1", "ENSXETG00000040212", "A0A6I8QZL1", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212" ] }, "reaction_10315803": { "compartment": "compartment_876", "id": "reaction_10315803", "reactome": "R-XTR-202717", "name": "Heterodimerization of CEACAMs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315799" ], "products": [ "species_10315801" ], "modifiers": [], "additional_components": [ "A0A6I8QZM7", "ENSXETG00000032631", "A0A6I8R329", "ENSXETG00000038658", "A0A6I8PPZ5", "ENSXETG00000038658", "A0A6I8SB02", "ENSXETG00000038658", "A0A6I8QZM7", "ENSXETG00000032631", "A0A6I8R329", "ENSXETG00000038658", "A0A6I8PPZ5", "ENSXETG00000038658", "A0A6I8SB02", "ENSXETG00000038658" ] }, "reaction_10327047": { "compartment": "compartment_876", "id": "reaction_10327047", "reactome": "R-XTR-2870221", "name": "E-selectin binds E-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315815", "species_10315821" ], "products": [ "species_10327045" ], "modifiers": [], "additional_components": [ "ENSXETG00000038109", "ENSXETG00000039556", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8R2I7", "ENSXETG00000038109" ] }, "reaction_10315831": { "compartment": "compartment_876", "id": "reaction_10315831", "reactome": "R-XTR-202731", "name": "JAM3 dimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315807" ], "products": [ "species_10315829" ], "modifiers": [], "additional_components": [ "ENSXETG00000040710", "A0A6I8SUC1", "ENSXETG00000040710" ] }, "reaction_10335414": { "compartment": "compartment_876", "id": "reaction_10335414", "reactome": "R-XTR-8858428", "name": "FCAMR binds IgA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335410", "species_10326437" ], "products": [ "species_10335412" ], "modifiers": [], "additional_components": [ "ENSXETG00000037809", "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8QLS0", "ENSXETG00000041230", "A0A6I8QM25", "ENSXETG00000041230", "A0A6I8PTS9", "ENSXETG00000041230", "A0A6I8RSN1", "ENSXETG00000041230", "A0A6I8PUH7", "ENSXETG00000041230", "A0A6I8S9Z8", "ENSXETG00000041230", "A0A6I8PM56", "ENSXETG00000041230", "A0A6I8RJH0", "ENSXETG00000041230", "A0A6I8PMK7", "ENSXETG00000041230", "A0A6I8RS78", "ENSXETG00000041230", "A0A6I8R4R2", "ENSXETG00000041230", "A0A6I8R767", "ENSXETG00000041230", "A0A6I8RSK9", "ENSXETG00000040383", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8RG22", 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"ENSXETG00000041230", "A0A6I8PUH7", "ENSXETG00000041230", "A0A6I8S9Z8", "ENSXETG00000041230", "A0A6I8PM56", "ENSXETG00000041230", "A0A6I8RJH0", "ENSXETG00000041230", "A0A6I8PMK7", "ENSXETG00000041230", "A0A6I8RS78", "ENSXETG00000041230", "A0A6I8R4R2", "ENSXETG00000041230", "A0A6I8R767", "ENSXETG00000041230", "A0A6I8RSK9", "ENSXETG00000040383", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212", "A0A6I8SK71", "ENSXETG00000040212", "A0A6I8QZL1", "ENSXETG00000040212", "A0A6I8RUJ4", "ENSXETG00000040212", "A0A6I8QKP4", "ENSXETG00000040212", "A0A6I8RNX1", "ENSXETG00000040212", "A0A6I8SYV6", "ENSXETG00000040212", "A0A6I8PWK1", "ENSXETT00000069302", "A0A6I8PXL5", "ENSXETT00000069302", "A0A5G3K4A2", "ENSXETT00000069302", "F7ATU6", "ENSXETT00000069302", 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"ENSXETT00000069302", "A0A6I8Q0S1", "ENSXETT00000069302", "A0A6I8Q2I9", "ENSXETT00000069302", "K9J7P7", "ENSXETT00000007797", "A0A6I8PSU3", "ENSXETG00000039428", "F6S2S6", "ENSXETT00000022997", "A0A6I8Q2V3", "ENSXETG00000039428", "A0A6I8RZZ7", "ENSXETG00000039428", "A0A6I8SEP6", "ENSXETG00000039428", "A0A6I8QNA7", "ENSXETG00000039428", "A0A6I8R2R2", "ENSXETG00000039428", "A0A6I8Q7C1", "ENSXETG00000039428", "A0A6I8QD99", "ENSXETG00000039428", "A0A6I8R5U7", "ENSXETG00000034776", "A0A6I8QSY3", "ENSXETG00000037809" ] }, "reaction_10335808": { "compartment": "compartment_876", "id": "reaction_10335808", "reactome": "R-XTR-8867240", "name": "EPCAM binds itself to form homotypic cell adhesion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335804" ], "products": [ "species_10335806" ], "modifiers": [], "additional_components": [ "ENSXETT00000060362", "Q5U4Z2", "ENSXETT00000060362" ] }, "reaction_10315827": { "compartment": "compartment_876", "id": "reaction_10315827", "reactome": "R-XTR-202724", "name": "P-selectin binds P-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315815", "species_10315823" ], "products": [ "species_10315825" ], "modifiers": [], "additional_components": [ "ENSXETG00000038109", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8R2I7", "ENSXETG00000038109" ] }, "reaction_10327054": { "compartment": "compartment_984", "id": "reaction_10327054", "reactome": "R-XTR-2872444", "name": "SLC9B1/C2 exchange Na+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10327051", "catalyst" ] ], "additional_components": [ "ENSXETG00000021321" ] }, "reaction_10327555": { "compartment": "compartment_70101", "id": "reaction_10327555", "reactome": "R-XTR-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10327552", "catalyst" ] ], "additional_components": [ "A0A6I8QKQ2", "ENSXETG00000031787", "A0A6I8SES7", "ENSXETG00000005811", "A0A6I8SY50", "ENSXETG00000001048", "A0A6I8RF46", "ENSXETG00000008633" ] }, "reaction_10327002": { "compartment": "compartment_70101", "id": "reaction_10327002", "reactome": "R-XTR-2671885", "name": "ASIC trimers:H+ transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10326999", "catalyst" ], [ "species_2672379", "inhibitor" ], [ "species_2672383", "inhibitor" ] ], "additional_components": [ "F6W3B8", "ENSXETT00000027176", "species_156540" ] }, "reaction_10335653": { "compartment": "compartment_876", "id": "reaction_10335653", "reactome": "R-XTR-8863494", "name": "ASICs bind STOML3, (STOM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335649", "species_10326999" ], "products": [ "species_10335651" ], "modifiers": [], "additional_components": [ "ENSXETT00000104043", "F6W3B8", "ENSXETT00000027176", "species_156540", "F6W3B8", "ENSXETT00000027176", "species_156540", "A0A1B8Y5B7", "ENSXETT00000104043" ] }, "reaction_10338020": { "compartment": "compartment_876", "id": "reaction_10338020", "reactome": "R-XTR-9650165", "name": "ASIC trimers bind H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338018", "species_351626" ], "products": [ "species_10326999" ], "modifiers": [], "additional_components": [ "F6W3B8", "ENSXETT00000027176", "F6W3B8", "ENSXETT00000027176", "species_156540" ] }, "reaction_10327041": { "compartment": "compartment_70101", "id": "reaction_10327041", "reactome": "R-XTR-2744349", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10327038", "catalyst" ] ], "additional_components": [ "ENSXETG00000003389" ] }, "reaction_10327027": { "compartment": "compartment_70101", "id": "reaction_10327027", "reactome": "R-XTR-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10327018", "catalyst" ], [ "species_10327023", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "A0A6I8SNU5", "ENSXETG00000031444", "A0A6I8SCS5", "ENSXETG00000034667", "A0A6I8PYE3", "ENSXETG00000031447", "ENSXETG00000039090" ] }, "reaction_10329555": { "compartment": "compartment_876", "id": "reaction_10329555", "reactome": "R-XTR-5333671", "name": "CLCAs self cleave", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329542" ], "products": [ "species_10327023", "species_10329548" ], "modifiers": [ [ "species_10329542", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "ENSXETG00000039090", "ENSXETG00000039090", "ENSXETG00000039090", "ENSXETG00000039090" ] }, "reaction_10327059": { "compartment": "compartment_17927", "id": "reaction_10327059", "reactome": "R-XTR-2889070", "name": "SLC9B2 exchanges Na+, Li+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_2889081" ], "products": [ "species_2889062", "species_163953" ], "modifiers": [ [ "species_10327056", "catalyst" ] ], "additional_components": [ "species_74113", "species_8953505", "species_8953505", "species_74113", "ENSXETG00000021321" ] }, "reaction_10325871": { "compartment": "compartment_12045", "id": "reaction_10325871", "reactome": "R-XTR-2046083", "name": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046053", "species_113601" ], "products": [ "species_113519", "species_162743", "species_159751", "species_2046060" ], "modifiers": [ [ "species_10319021", "catalyst" ] ], "additional_components": [ "ENSXETT00000034904" ] }, "reaction_10325880": { "compartment": "compartment_17957", "id": "reaction_10325880", "reactome": "R-XTR-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_113519", "species_113564", "species_162743", "species_159751", "species_2046045" ], "modifiers": [ [ "species_10319021", "catalyst" ] ], "additional_components": [ "ENSXETT00000034904" ] }, "reaction_10325878": { "compartment": "compartment_12045", "id": "reaction_10325878", "reactome": "R-XTR-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_5228339", "species_2046055", "species_211606" ], "modifiers": [ [ "species_10317279", "catalyst" ] ], "additional_components": [ "ENSXETG00000007705" ] }, "reaction_10320759": { "compartment": "compartment_876", "id": "reaction_10320759", "reactome": "R-XTR-975449", "name": "GABRR pentamers:GABA transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10320756", "catalyst" ] ], "additional_components": [ "species_428571", "A0A6I8QVR1", "ENSXETG00000030855" ] }, "reaction_10320748": { "compartment": "compartment_876", "id": "reaction_10320748", "reactome": "R-XTR-975311", "name": "HTR3 pentamers:5HT transport Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_74112", "species_74113" ], "products": [ "species_29804", "species_83910", "species_74016" ], "modifiers": [ [ "species_10320745", "catalyst" ] ], "additional_components": [ "species_114523", "A0A6I8QAS1", "ENSXETG00000031115", "A0A6I8RJM1", "ENSXETG00000031022" ] }, "reaction_10338012": { "compartment": "compartment_876", "id": "reaction_10338012", "reactome": "R-XTR-9648983", "name": "HTR3A pentamer:5HT transports Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_74112", "species_74113" ], "products": [ "species_29804", "species_83910", "species_74016" ], "modifiers": [ [ "species_10338009", "catalyst" ] ], "additional_components": [ "A0A6I8QAS1", "ENSXETG00000031115", "species_114523" ] }, "reaction_10337600": { "compartment": "compartment_7660", "id": "reaction_10337600", "reactome": "R-XTR-9029434", "name": "p-S363,S380,T573 RS6K translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337590" ], "products": [ "species_10337598" ], "modifiers": [], "additional_components": [ "F7DTA9", "ENSXETT00000051850", "F6YXI9", "ENSXETT00000008599", "F6YXI9", "ENSXETT00000008599", "F7DTA9", "ENSXETT00000051850" ] }, "reaction_10338016": { "compartment": "compartment_876", "id": "reaction_10338016", "reactome": "R-XTR-9649108", "name": "HTR3A pentamer binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10338014" ], "products": [ "species_10338009" ], "modifiers": [], "additional_components": [ "A0A6I8QAS1", "ENSXETG00000031115", "A0A6I8QAS1", "ENSXETG00000031115", "species_114523" ] }, "reaction_10316794": { "compartment": "compartment_374932", "id": "reaction_10316794", "reactome": "R-XTR-372542", "name": "Loading of dopamine into synaptic veiscles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159362" ], "products": [ "species_351601" ], "modifiers": [ [ "species_10316791", "catalyst" ] ], "additional_components": [ "ENSXETG00000038313" ] }, "reaction_10317198": { "compartment": "compartment_374932", "id": "reaction_10317198", "reactome": "R-XTR-380586", "name": "loading of Serotonin in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209914" ], "products": [ "species_380585" ], "modifiers": [ [ "species_10316791", "catalyst" ] ], "additional_components": [ "ENSXETG00000038313" ] }, "reaction_10333989": { "compartment": "compartment_161320", "id": "reaction_10333989", "reactome": "R-XTR-6803753", "name": "NAAA hydrolyses NAEs to FAs and ethanolamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6803725" ], "products": [ "species_6803745", "species_6803778" ], "modifiers": [ [ "species_10333986", "catalyst" ] ], "additional_components": [ "CHEBI:71466", "CHEBI:2700", "CHEBI:85299", "CHEBI:85263", "CHEBI:71464", "CHEBI:85262", "species_3632881", "CHEBI:30805", "CHEBI:9254", "CHEBI:28875", "CHEBI:16196", "species_140356", "Q6DJ82", "ENSXETT00000057513" ] }, "reaction_10320187": { "compartment": "compartment_917757", "id": "reaction_10320187", "reactome": "R-XTR-888577", "name": "Synthesis of GABA by GAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10320184", "catalyst" ] ], "additional_components": [ "F6YRI6", "ENSXETT00000012900" ] }, "reaction_10320192": { "compartment": "compartment_70101", "id": "reaction_10320192", "reactome": "R-XTR-888592", "name": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352011" ], "products": [ "species_428571" ], "modifiers": [ [ "species_10320189", "catalyst" ] ], "additional_components": [ "ENSXETT00000054324" ] }, "reaction_10316559": { "compartment": "compartment_876", "id": "reaction_10316559", "reactome": "R-XTR-212642", "name": "L-Glutamine transport into neurons", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_212615", "species_74113" ], "products": [ "species_83910", "species_29472" ], "modifiers": [ [ "species_10316556", "catalyst" ] ], "additional_components": [ "ENSXETG00000014662" ] }, "reaction_10316154": { "compartment": "compartment_70101", "id": "reaction_10316154", "reactome": "R-XTR-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_10316149" ], "products": [ "species_10316151" ], "modifiers": [ [ "species_10316149", "catalyst" ] ], "additional_components": [ "Q28H43", "ENSXETT00000090296", "Q05B21", "ENSXETT00000082042", "A0A6I8Q031", "ENSXETG00000008255", "Q28H43", "ENSXETT00000090296", "Q05B21", "ENSXETT00000082042", "species_210382", "A0A6I8Q031", "ENSXETG00000008255", "Q28H43", "ENSXETT00000090296", "Q05B21", "ENSXETT00000082042", "A0A6I8Q031", "ENSXETG00000008255" ] }, "reaction_10316115": { "compartment": "compartment_984", "id": "reaction_10316115", "reactome": "R-XTR-210404", "name": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_210382", "species_29804", "species_74113" ], "products": [ "species_74126", "species_29404", "species_70106", "species_83910" ], "modifiers": [ [ "species_10316108", "catalyst" ], [ "species_10316113", "inhibitor" ] ], "additional_components": [ "ENSXETG00000011685", "ENSXETT00000102749" ] }, "reaction_10316133": { "compartment": "compartment_984", "id": "reaction_10316133", "reactome": "R-XTR-210420", "name": "Ca2+ influx through voltage gated Ca2+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10316130", "catalyst" ], [ "species_74126", "inhibitor" ] ], "additional_components": [ "A0A6I8PYQ9", "ENSXETG00000021694", "A0A6I8SXZ7", "ENSXETG00000005585" ] }, "reaction_10337901": { "compartment": "compartment_876", "id": "reaction_10337901", "reactome": "R-XTR-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9634838", "species_10316781" ], "products": [ "species_10316784" ], "modifiers": [], "additional_components": [ "A0A6I8Q0V4", "ENSXETG00000030902", "A0A5G3JDL4", "ENSXETT00000103127", "A0A6I8Q0V4", "ENSXETG00000030902", "A0A5G3JDL4", "ENSXETT00000103127" ] }, "reaction_10317200": { "compartment": "compartment_5460", "id": "reaction_10317200", "reactome": "R-XTR-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_380598" ], "products": [ "species_113529", "species_380593", "species_29362" ], "modifiers": [ [ "species_10311857", "catalyst" ] ], "additional_components": [ "A0A6I8RHR6", "ENSXETG00000020930" ] }, "reaction_10317171": { "compartment": "compartment_70101", "id": "reaction_10317171", "reactome": "R-XTR-379464", "name": "COMT transfers Met to DOPAC to form HVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9677997", "species_71284" ], "products": [ "species_9677992", "species_174369" ], "modifiers": [ [ "species_10317160", "catalyst" ] ], "additional_components": [ "ENSXETT00000064849" ] }, "reaction_10317165": { "compartment": "compartment_70101", "id": "reaction_10317165", "reactome": "R-XTR-379387", "name": "COMT transfers Met to DA to form 3MT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_159362" ], "products": [ "species_8954997", "species_71285" ], "modifiers": [ [ "species_10317160", "catalyst" ], [ "species_10317163", "inhibitor" ] ], "additional_components": [ "ENSXETT00000064849", "A9UMU1", "ENSXETT00000064849" ] }, "reaction_10336969": { "compartment": "compartment_70101", "id": "reaction_10336969", "reactome": "R-XTR-8955010", "name": "LRTOMT transfers Met to DA, forming 3MT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_159362" ], "products": [ "species_8954997", "species_71285" ], "modifiers": [ [ "species_10336966", "catalyst" ] ], "additional_components": [ "ENSXETG00000039768" ] }, "reaction_10338104": { "compartment": "compartment_876", "id": "reaction_10338104", "reactome": "R-XTR-9679775", "name": "COMT binds COMT Inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317160", "species_9679778" ], "products": [ "species_10317163" ], "modifiers": [], "additional_components": [ "ENSXETT00000064849", "A9UMU1", "ENSXETT00000064849" ] }, "reaction_10316786": { "compartment": "compartment_984", "id": "reaction_10316786", "reactome": "R-XTR-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10316781", "catalyst" ], [ "species_10316784", "inhibitor" ] ], "additional_components": [ "A0A6I8Q0V4", "ENSXETG00000030902", "A0A5G3JDL4", "ENSXETT00000103127", "A0A6I8Q0V4", "ENSXETG00000030902", "A0A5G3JDL4", "ENSXETT00000103127" ] }, "reaction_10316552": { "compartment": "compartment_984", "id": "reaction_10316552", "reactome": "R-XTR-212614", "name": "Glutamine transport from astrocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472" ], "products": [ "species_212615" ], "modifiers": [ [ "species_10316549", "catalyst" ] ], "additional_components": [ "ENSXETG00000041195" ] }, "reaction_10311522": { "compartment": "compartment_70101", "id": "reaction_10311522", "reactome": "R-XTR-70606", "name": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113592", "species_31633" ], "products": [ "species_29372", "species_29370", "species_29472" ], "modifiers": [ [ "species_10311519", "catalyst" ] ], "additional_components": [ "F6VAG8", "ENSXETT00000027374" ] }, "reaction_10338094": { "compartment": "compartment_70101", "id": "reaction_10338094", "reactome": "R-XTR-9679029", "name": "C-ter TLR7 dimer binds HCQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338090", "species_9678628" ], "products": [ "species_10338092" ], "modifiers": [], "additional_components": [ "F7EDI8", "ENSXETT00000013094", "F7EDI8", "ENSXETT00000013094" ] }, "reaction_10313351": { "compartment": "compartment_70101", "id": "reaction_10313351", "reactome": "R-XTR-168166", "name": "NFkB complex is transported from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313343" ], "products": [ "species_10313349" ], "modifiers": [], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173" ] }, "reaction_10312161": { "compartment": "compartment_7660", "id": "reaction_10312161", "reactome": "R-XTR-75998", "name": "Formation of RAD52 heptameric ring structure complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312157" ], "products": [ "species_10312159" ], "modifiers": [], "additional_components": [ "ENSXETG00000009413", "A0A6I8RDE5", "ENSXETG00000009413" ] }, "reaction_10337038": { "compartment": "compartment_70101", "id": "reaction_10337038", "reactome": "R-XTR-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317378", "species_10312717" ], "products": [ "species_10317376", "species_10317380" ], "modifiers": [], "additional_components": [ "A0A6I8T271", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10330050": { "compartment": "compartment_70101", "id": "reaction_10330050", "reactome": "R-XTR-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10317380" ], "products": [ "species_29370", "species_10329598", "species_10312717" ], "modifiers": [ [ "species_10317380", "catalyst" ] ], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8T271", "ENSXETG00000011808", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10314369": { "compartment": "compartment_947587", "id": "reaction_10314369", "reactome": "R-XTR-198266", "name": "PI3K produces PIP3 and other phosphatidyl inositides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10314366", "catalyst" ] ], "additional_components": [ "A0A6I8RAF1", "ENSXETG00000039550", "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252" ] }, "reaction_10337673": { "compartment": "compartment_876", "id": "reaction_10337673", "reactome": "R-XTR-9034714", "name": "NTRK3 dimers trans-autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10337661" ], "products": [ "species_10337670", "species_29370" ], "modifiers": [ [ "species_10337661", "catalyst" ] ], "additional_components": [ "F6VUP1", "ENSXETT00000036251", "A0A6I8T1S6", "ENSXETG00000033787", "F6VUP1", "ENSXETT00000036251", "A0A6I8T1S6", "ENSXETG00000033787", "F6VUP1", "ENSXETT00000036251", "A0A6I8T1S6", "ENSXETG00000033787" ] }, "reaction_10334500": { "compartment": "compartment_12045", "id": "reaction_10334500", "reactome": "R-XTR-6807055", "name": "DHCR7 reduces 7-dehydroCHOL to CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6807057", "species_29364" ], "products": [ "species_193384", "species_29366" ], "modifiers": [ [ "species_10314334", "catalyst" ] ], "additional_components": [ "ENSXETG00000008945" ] }, "reaction_10334502": { "compartment": "compartment_12045", "id": "reaction_10334502", "reactome": "R-XTR-6807064", "name": "DHCR24 reduces ZYMOL to ZYMSTNL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194691" ], "products": [ "species_6807048", "species_29366" ], "modifiers": [ [ "species_10314341", "catalyst" ] ], "additional_components": [ "ENSXETG00000020010" ] }, "reaction_10334498": { "compartment": "compartment_12045", "id": "reaction_10334498", "reactome": "R-XTR-6807053", "name": "SC5D desaturates LTHSOL to 7-dehydroCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6807054", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_6807057" ], "modifiers": [ [ "species_10314319", "catalyst" ] ], "additional_components": [ "ENSXETG00000040073" ] }, "reaction_10332459": { "compartment": "compartment_7660", "id": "reaction_10332459", "reactome": "R-XTR-6797090", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10332455", "species_10312628" ], "products": [ "species_10332457" ], "modifiers": [], "additional_components": [ "ENSXETG00000023695", "ENSXETT00000049621", "F7CLE9", "ENSXETT00000049621", "B5DE93", "ENSXETG00000023695" ] }, "reaction_10332465": { "compartment": "compartment_7660", "id": "reaction_10332465", "reactome": "R-XTR-6797100", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312628", "species_10332461" ], "products": [ "species_10332463" ], "modifiers": [], "additional_components": [ "ENSXETT00000049621", "ENSXETG00000023695", "B5DE93", "ENSXETG00000023695", "F7CLE9", "ENSXETT00000049621" ] }, "reaction_10314021": { "compartment": "compartment_7660", "id": "reaction_10314021", "reactome": "R-XTR-187934", "name": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313994", "species_10313486" ], "products": [ "species_10314013" ], "modifiers": [ [ "species_10313994", "catalyst" ] ], "additional_components": [ "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130", "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125", "ENSXETG00000038125" ] }, "reaction_10330057": { "compartment": "compartment_70101", "id": "reaction_10330057", "reactome": "R-XTR-5628905", "name": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30533" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10330054", "catalyst" ] ], "additional_components": [ "ENSXETG00000005971" ] }, "reaction_10330082": { "compartment": "compartment_70101", "id": "reaction_10330082", "reactome": "R-XTR-5632738", "name": "DDIT4 binds 14-3-3 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312804", "species_10330078" ], "products": [ "species_10330080" ], "modifiers": [], "additional_components": [ "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830", "ENSXETT00000083124", "Q6P4J6", "ENSXETT00000083124", "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830" ] }, "reaction_10333927": { "compartment": "compartment_74700", "id": "reaction_10333927", "reactome": "R-XTR-6801195", "name": "STEAP3 binds BNIP3L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333923", "species_10320592" ], "products": [ "species_10333925" ], "modifiers": [], "additional_components": [ "ENSXETT00000022422", "ENSXETT00000016208", "F6YGT5", "ENSXETT00000016208", "F7AAW4", "ENSXETT00000022422" ] }, "reaction_10333915": { "compartment": "compartment_70101", "id": "reaction_10333915", "reactome": "R-XTR-6800793", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333911" ], "products": [ "species_10333913" ], "modifiers": [], "additional_components": [ "ENSXETG00000033984", "ENSXETG00000033984" ] }, "reaction_10320843": { "compartment": "compartment_70101", "id": "reaction_10320843", "reactome": "R-XTR-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_29372", "species_200736" ], "modifiers": [ [ "species_10320840", "catalyst" ] ], "additional_components": [ "species_109496", "A0A6I8R2I0", "ENSXETG00000041151" ] }, "reaction_10335757": { "compartment": "compartment_876", "id": "reaction_10335757", "reactome": "R-XTR-8866269", "name": "ARRB bind GPCRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335751", "species_10335753" ], "products": [ "species_10335755" ], "modifiers": [], "additional_components": [ "F6SUX3", "ENSXETT00000050169", "F6SKI7", "ENSXETT00000021189", "F6SUX3", "ENSXETT00000050169", "F6SKI7", "ENSXETT00000021189" ] }, "reaction_10338108": { "compartment": "compartment_70101", "id": "reaction_10338108", "reactome": "R-XTR-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9648300", "species_10335334" ], "products": [ "species_10335769" ], "modifiers": [], "additional_components": [ "A0A6I8RNH9", "ENSXETG00000013480", "A0A6I8PJR6", "ENSXETG00000009033", "Q6P856", "ENSXETG00000017276", "A0A6I8RNH9", "ENSXETG00000013480", "A0A6I8PJR6", "ENSXETG00000009033", "Q6P856", "ENSXETG00000017276" ] }, "reaction_10335647": { "compartment": "compartment_876", "id": "reaction_10335647", "reactome": "R-XTR-8863463", "name": "STON2 binds SYT proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335633", "species_10335643" ], "products": [ "species_10335645" ], "modifiers": [], "additional_components": [ "A0A6I8PYV5", "ENSXETG00000034334", "A0A6I8SQ61", "ENSXETG00000038939", "A0A6I8SQ61", "ENSXETG00000038939", "A0A6I8PYV5", "ENSXETG00000034334" ] }, "reaction_10335771": { "compartment": "compartment_876", "id": "reaction_10335771", "reactome": "R-XTR-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335334", "species_10335765" ], "products": [ "species_10335767" ], "modifiers": [ [ "species_10335769", "inhibitor" ] ], "additional_components": [ "A0A6I8RNH9", "ENSXETG00000013480", "A0A6I8PJR6", "ENSXETG00000009033", "Q6P856", "ENSXETG00000017276", "F7BD23", "ENSXETT00000017485", "A0A6I8QYZ2", "ENSXETG00000039705", "A0A6I8QZE2", "ENSXETG00000040690", "species_912516", "Q501K5", "ENSXETG00000011814", "A0A6I8QXB4", "ENSXETG00000021138", "F7BD23", "ENSXETT00000017485", "A0A6I8QYZ2", "ENSXETG00000039705", "A0A6I8QZE2", "ENSXETG00000040690", "species_912516", "Q501K5", "ENSXETG00000011814", "A0A6I8QXB4", "ENSXETG00000021138", "A0A6I8RNH9", "ENSXETG00000013480", "A0A6I8PJR6", "ENSXETG00000009033", "Q6P856", "ENSXETG00000017276", "A0A6I8RNH9", "ENSXETG00000013480", "A0A6I8PJR6", "ENSXETG00000009033", "Q6P856", "ENSXETG00000017276" ] }, "reaction_10335824": { "compartment": "compartment_876", "id": "reaction_10335824", "reactome": "R-XTR-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335810", "species_10335820" ], "products": [ "species_10335822" ], "modifiers": [], "additional_components": [ "ENSXETG00000008255", "A0A6I8Q6S5", "ENSXETG00000032563", "A0A6I8Q6S5", "ENSXETG00000032563", "A0A6I8Q031", "ENSXETG00000008255" ] }, "reaction_10335841": { "compartment": "compartment_876", "id": "reaction_10335841", "reactome": "R-XTR-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10323969", "catalyst" ] ], "additional_components": [ "ENSXETT00000042073" ] }, "reaction_10327264": { "compartment": "compartment_70101", "id": "reaction_10327264", "reactome": "R-XTR-3134804", "name": "STING ubiquitination by TRIM32 or TRIM56", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324513", "species_10312116" ], "products": [ "species_10327258", "species_10324511" ], "modifiers": [ [ "species_10324513", "catalyst" ] ], "additional_components": [ "A0A6I8SBS8", "ENSXETG00000039978", "A8E5V9", "ENSXETG00000016088", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "ENSXETG00000016088", "ENSXETG00000039978", "A0A6I8SBS8", "ENSXETG00000039978", "A8E5V9", "ENSXETG00000016088" ] }, "reaction_10324515": { "compartment": "compartment_70101", "id": "reaction_10324515", "reactome": "R-XTR-1964496", "name": "STING binds TRIM32 or TRIM56 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324507", "species_10324511" ], "products": [ "species_10324513" ], "modifiers": [], "additional_components": [ "ENSXETG00000016088", "ENSXETG00000039978", "A0A6I8SBS8", "ENSXETG00000039978", "A8E5V9", "ENSXETG00000016088" ] }, "reaction_10316740": { "compartment": "compartment_876", "id": "reaction_10316740", "reactome": "R-XTR-352108", "name": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352091", "species_74113" ], "products": [ "species_352088", "species_83910" ], "modifiers": [ [ "species_10316556", "catalyst" ] ], "additional_components": [ "species_29432", "species_29472", "species_379717", "CHEBI:57926", "species_200736", "CHEBI:58048", "species_159549", "species_29588", "species_174390", "species_29472", "species_159549", "species_379717", "species_200736", "CHEBI:57926", "species_29588", "species_174390", "species_29432", "CHEBI:58048", "ENSXETG00000014662" ] }, "reaction_10316756": { "compartment": "compartment_876", "id": "reaction_10316756", "reactome": "R-XTR-352232", "name": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352229" ], "products": [ "species_352227" ], "modifiers": [ [ "species_10316753", "catalyst" ] ], "additional_components": [ "species_29500", "CHEBI:58045", "species_29612", "species_29588", "species_174390", "CHEBI:58315", "species_351993", "CHEBI:57762", "CHEBI:58315", "species_29588", "species_174390", "CHEBI:58045", "CHEBI:57762", "species_29612", "species_29500", "species_351993", "B5DDZ9", "ENSXETT00000061667", "F6YKM8", "ENSXETT00000042158" ] }, "reaction_10316743": { "compartment": "compartment_876", "id": "reaction_10316743", "reactome": "R-XTR-352119", "name": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352123", "species_74113" ], "products": [ "species_352105", "species_83910" ], "modifiers": [ [ "species_10316549", "catalyst" ] ], "additional_components": [ "species_29432", "species_29472", "species_200736", "CHEBI:58048", "species_174390", "species_29472", "species_200736", "species_174390", "species_29432", "CHEBI:58048", "ENSXETG00000041195" ] }, "reaction_10317169": { "compartment": "compartment_876", "id": "reaction_10317169", "reactome": "R-XTR-379426", "name": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_351964", "species_74113" ], "products": [ "species_351977", "species_83910", "species_29588" ], "modifiers": [ [ "species_10317013", "catalyst" ] ], "additional_components": [ "F6YKM8", "ENSXETT00000042158", "Q28I80", "ENSXETT00000014625" ] }, "reaction_10316738": { "compartment": "compartment_876", "id": "reaction_10316738", "reactome": "R-XTR-352107", "name": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352101" ], "products": [ "species_352114" ], "modifiers": [ [ "species_10316735", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "species_29588", "species_174390", "species_351993", "CHEBI:57762", "species_29588", "species_174390", "CHEBI:58045", "CHEBI:57762", "species_351993", "ENSXETG00000022279" ] }, "reaction_10317920": { "compartment": "compartment_876", "id": "reaction_10317920", "reactome": "R-XTR-425678", "name": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_74016", "species_74113" ], "products": [ "species_74126", "species_83910", "species_74112" ], "modifiers": [ [ "species_10317917", "catalyst" ] ], "additional_components": [ "ENSXETG00000010290" ] }, "reaction_10335224": { "compartment": "compartment_70101", "id": "reaction_10335224", "reactome": "R-XTR-8855062", "name": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162252", "species_71284" ], "products": [ "species_2162265", "species_71285" ], "modifiers": [ [ "species_10335221", "catalyst" ] ], "additional_components": [ "ENSXETG00000026858" ] }, "reaction_10317940": { "compartment": "compartment_876", "id": "reaction_10317940", "reactome": "R-XTR-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10317937", "catalyst" ] ], "additional_components": [ "A0A6I8PNM9", "ENSXETG00000033166", "A0A6I8S3I9", "ENSXETG00000040616" ] }, "reaction_10317927": { "compartment": "compartment_172574", "id": "reaction_10317927", "reactome": "R-XTR-425965", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425999", "species_83910" ], "products": [ "species_425977", "species_70106" ], "modifiers": [ [ "species_10317924", "catalyst" ] ], "additional_components": [ "ENSXETT00000029654" ] }, "reaction_10318058": { "compartment": "compartment_876", "id": "reaction_10318058", "reactome": "R-XTR-428015", "name": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428027", "species_29804", "species_74113" ], "products": [ "species_74126", "species_427997", "species_70106", "species_83910" ], "modifiers": [ [ "species_10316108", "catalyst" ] ], "additional_components": [ "species_29448", "species_6810061", "species_210382", "species_29448", "species_6810061", "species_210382", "ENSXETG00000011685" ] }, "reaction_10318141": { "compartment": "compartment_876", "id": "reaction_10318141", "reactome": "R-XTR-429749", "name": "SLC5A8 transports monocarboxylates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429739", "species_74113" ], "products": [ "species_83910", "species_429748" ], "modifiers": [ [ "species_10318138", "catalyst" ] ], "additional_components": [ "species_29398", "species_373863", "CHEBI:32544", "species_76179", "species_29416", "CHEBI:30768", "species_76179", "species_29398", "species_29416", "species_373863", "CHEBI:30768", "CHEBI:15940", "ENSXETG00000031274" ] }, "reaction_10318063": { "compartment": "compartment_201753", "id": "reaction_10318063", "reactome": "R-XTR-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_428548" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10318060", "catalyst" ] ], "additional_components": [ "ENSXETT00000082042" ] }, "reaction_10318144": { "compartment": "compartment_876", "id": "reaction_10318144", "reactome": "R-XTR-429767", "name": "Passive I- efflux mediated by SMCT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10318138", "catalyst" ] ], "additional_components": [ "ENSXETG00000031274" ] }, "reaction_10318084": { "compartment": "compartment_201753", "id": "reaction_10318084", "reactome": "R-XTR-428625", "name": "Vesicular inhibitory amino acid transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428592", "species_428548" ], "products": [ "species_428632", "species_70106" ], "modifiers": [ [ "species_10318081", "catalyst" ] ], "additional_components": [ "species_159549", "species_428571", "species_428571", "species_159549", "ENSXETT00000054324" ] }, "reaction_10318014": { "compartment": "compartment_876", "id": "reaction_10318014", "reactome": "R-XTR-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10318011", "catalyst" ] ], "additional_components": [ "ENSXETG00000005947" ] }, "reaction_10335952": { "compartment": "compartment_70101", "id": "reaction_10335952", "reactome": "R-XTR-8876312", "name": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8876310", "species_74113" ], "products": [ "species_83910", "species_8876304" ], "modifiers": [ [ "species_10335949", "catalyst" ] ], "additional_components": [ "species_29398", "species_373863", "CHEBI:32544", "species_29398", "species_373863", "CHEBI:15940", "ENSXETG00000025601" ] }, "reaction_10318034": { "compartment": "compartment_876", "id": "reaction_10318034", "reactome": "R-XTR-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_111627" ], "products": [ "species_425425", "species_352022" ], "modifiers": [ [ "species_10318031", "catalyst" ] ], "additional_components": [ "ENSXETG00000016188" ] }, "reaction_10318027": { "compartment": "compartment_876", "id": "reaction_10318027", "reactome": "R-XTR-427605", "name": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10318024", "catalyst" ] ], "additional_components": [ "Q28E01", "ENSXETG00000009532", "Q5BL44", "ENSXETT00000041138" ] }, "reaction_10312261": { "compartment": "compartment_7660", "id": "reaction_10312261", "reactome": "R-XTR-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312257", "species_10312253" ], "products": [ "species_10312259" ], "modifiers": [], "additional_components": [ "ENSXETG00000010179", "ENSXETT00000041997", "Q6DES0", "ENSXETT00000041997", "Q6DIE2", "ENSXETG00000010179" ] }, "reaction_10318606": { "compartment": "compartment_70101", "id": "reaction_10318606", "reactome": "R-XTR-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450523", "species_10318588" ], "products": [ "species_10318590" ], "modifiers": [], "additional_components": [ "ENSXETG00000030723", "A0A6I8SGT0", "ENSXETG00000030723" ] }, "reaction_10318952": { "compartment": "compartment_70101", "id": "reaction_10318952", "reactome": "R-XTR-482788", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312800", "species_10318596" ], "products": [ "species_10318950" ], "modifiers": [], "additional_components": [ "ENSXETG00000022830", "A0A6I8SGT0", "ENSXETG00000030723", "A0A6I8SGT0", "ENSXETG00000030723", "Q5XGC8", "ENSXETG00000022830" ] }, "reaction_10318586": { "compartment": "compartment_70101", "id": "reaction_10318586", "reactome": "R-XTR-450406", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312800", "species_10318582" ], "products": [ "species_10318584" ], "modifiers": [], "additional_components": [ "ENSXETG00000022830", "A0A6I8SGT0", "ENSXETG00000030723", "A0A6I8SGT0", "ENSXETG00000030723", "Q5XGC8", "ENSXETG00000022830" ] }, "reaction_10318604": { "compartment": "compartment_7660", "id": "reaction_10318604", "reactome": "R-XTR-450494", "name": "HuR binds mRNAs in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318600", "species_450613" ], "products": [ "species_10318602" ], "modifiers": [], "additional_components": [ "ENSXETG00000008752", "Q6GLB5", "ENSXETG00000008752" ] }, "reaction_10319007": { "compartment": "compartment_7660", "id": "reaction_10319007", "reactome": "R-XTR-517705", "name": "p-S318,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318610", "species_517622" ], "products": [ "species_10319005" ], "modifiers": [], "additional_components": [ "ENSXETG00000008752", "Q6GLB5", "ENSXETG00000008752" ] }, "reaction_10319003": { "compartment": "compartment_7660", "id": "reaction_10319003", "reactome": "R-XTR-517674", "name": "p-S158,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450605", "species_10318613" ], "products": [ "species_10319001" ], "modifiers": [], "additional_components": [ "ENSXETG00000008752", "Q6GLB5", "ENSXETG00000008752" ] }, "reaction_10314047": { "compartment": "compartment_984", "id": "reaction_10314047", "reactome": "R-XTR-188979", "name": "Digestion of linear starch (amylose) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189075" ], "products": [ "species_191103", "species_188986" ], "modifiers": [ [ "species_10314044", "catalyst" ] ], "additional_components": [ "species_70113", "ENSXETG00000010847" ] }, "reaction_10314056": { "compartment": "compartment_984", "id": "reaction_10314056", "reactome": "R-XTR-189062", "name": "lactose + H2O => D-glucose + D-galactose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188973", "species_109276" ], "products": [ "species_70115", "species_188995" ], "modifiers": [ [ "species_10314053", "catalyst" ] ], "additional_components": [ "A0A6I8SYH9", "ENSXETG00000025031" ] }, "reaction_10314145": { "compartment": "compartment_984", "id": "reaction_10314145", "reactome": "R-XTR-191114", "name": "Digestion of branched starch (amylopectin) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189071" ], "products": [ "species_191103", "species_188986", "species_189108" ], "modifiers": [ [ "species_10314044", "catalyst" ] ], "additional_components": [ "species_70113", "ENSXETG00000010847" ] }, "reaction_10328964": { "compartment": "compartment_7660", "id": "reaction_10328964", "reactome": "R-XTR-4755536", "name": "PIAS3 SUMOylates RELA with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327222", "species_10328953" ], "products": [ "species_10328962", "species_10327128" ], "modifiers": [ [ "species_10328492", "catalyst" ] ], "additional_components": [ "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8PS73", "ENSXETG00000026173", "ENSXETT00000054232", "ENSXETG00000018642" ] }, "reaction_10334705": { "compartment": "compartment_20699", "id": "reaction_10334705", "reactome": "R-XTR-8848484", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_29356" ], "products": [ "species_6814303", "species_8848483" ], "modifiers": [ [ "species_10318101", "catalyst" ] ], "additional_components": [ "ENSXETT00000066288" ] }, "reaction_10335199": { "compartment": "compartment_17938", "id": "reaction_10335199", "reactome": "R-XTR-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10335194" ], "products": [ "species_29372", "species_10335196" ], "modifiers": [ [ "species_10335194", "catalyst" ] ], "additional_components": [ "species_29438", "F7A377", "ENSXETT00000029250", "F7A377", "ENSXETT00000029250", "species_29420", "species_29438", "F7A377", "ENSXETT00000029250" ] }, "reaction_10335189": { "compartment": "compartment_24339", "id": "reaction_10335189", "reactome": "R-XTR-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10335180" ], "products": [ "species_29372", "species_10335182" ], "modifiers": [ [ "species_10335180", "catalyst" ], [ "species_10335187", "catalyst" ] ], "additional_components": [ "Q6P7Z7", "ENSXETT00000056541", "species_29438", "Q6P7Z7", "ENSXETT00000056541", "species_29420", "Q6P7Z7", "ENSXETT00000056541", "species_29438", "ENSXETT00000043751" ] }, "reaction_10335207": { "compartment": "compartment_17938", "id": "reaction_10335207", "reactome": "R-XTR-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10335194" ], "products": [ "species_29372", "species_10335205" ], "modifiers": [ [ "species_10335194", "catalyst" ] ], "additional_components": [ "species_29438", "F7A377", "ENSXETT00000029250", "species_29420", "F7A377", "ENSXETT00000029250", "species_29438", "F7A377", "ENSXETT00000029250" ] }, "reaction_10335984": { "compartment": "compartment_70101", "id": "reaction_10335984", "reactome": "R-XTR-8876446", "name": "p-ULK1 phosphorylates DENND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335969", "species_113592" ], "products": [ "species_29370", "species_10335973" ], "modifiers": [ [ "species_10335981", "catalyst" ] ], "additional_components": [ "ENSXETT00000054527", "ENSXETT00000054527", "ENSXETG00000002028" ] }, "reaction_10318634": { "compartment": "compartment_70101", "id": "reaction_10318634", "reactome": "R-XTR-451056", "name": "Microtubule-independent trafficking of connexons to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318628" ], "products": [ "species_10318632" ], "modifiers": [], "additional_components": [ "Q28ED4", "ENSXETT00000055228", "Q28ED4", "ENSXETT00000055228" ] }, "reaction_10314143": { "compartment": "compartment_12045", "id": "reaction_10314143", "reactome": "R-XTR-190681", "name": "Connexin oligomerization in endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314138" ], "products": [ "species_10314140" ], "modifiers": [ [ "species_10314138", "catalyst" ] ], "additional_components": [ "ENSXETT00000055497", "Q6NVT8", "ENSXETT00000055497", "ENSXETT00000055497" ] }, "reaction_10335934": { "compartment": "compartment_20699", "id": "reaction_10335934", "reactome": "R-XTR-8874979", "name": "ACBD3 binds GOLGB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335924", "species_10335930" ], "products": [ "species_10335932" ], "modifiers": [], "additional_components": [ "ENSXETT00000048980", "A0A6I8PMP5", "ENSXETG00000033340", "A0A6I8PMP5", "ENSXETG00000033340", "F6WGE2", "ENSXETT00000048980" ] }, "reaction_10326647": { "compartment": "compartment_24337", "id": "reaction_10326647", "reactome": "R-XTR-2247512", "name": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326631" ], "products": [ "species_10326645" ], "modifiers": [], "additional_components": [ "species_426658", "species_33625", "CHEBI:28640", "species_2186967", "species_30495", "CHEBI:37671", "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "species_171142", "species_216762", "CHEBI:60479", "CHEBI:64009", "CHEBI:64294", "A0A6I8RKY6", "ENSXETG00000026768", "CHEBI:24654", "A0A6I8S279", "ENSXETG00000037724", "A0A6I8S279", "ENSXETG00000037724", "CHEBI:64294", "CHEBI:60479", "species_171126", "species_171142", "CHEBI:24654", "A0A6I8RKY6", "ENSXETG00000026768", "CHEBI:64009", "species_163579", "species_216762", "CHEBI:28640", "species_426658", "species_30495", "species_2186967", "CHEBI:37671", "A0A6I8PU04", "ENSXETG00000033423", "species_33625" ] }, "reaction_10318182": { "compartment": "compartment_876", "id": "reaction_10318182", "reactome": "R-XTR-434381", "name": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_400452" ], "products": [ "species_3632881" ], "modifiers": [ [ "species_10318179", "catalyst" ] ], "additional_components": [ "ENSXETG00000037724" ] }, "reaction_10329322": { "compartment": "compartment_13231", "id": "reaction_10329322", "reactome": "R-XTR-5223304", "name": "DAG and Ca+2 bind to PKC and tether it to membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329318", "species_5221124", "species_29496" ], "products": [ "species_10329320" ], "modifiers": [], "additional_components": [ "ENSXETG00000017294", "species_74112", "species_114519", "A8KBH6", "ENSXETG00000017294" ] }, "reaction_10326334": { "compartment": "compartment_7660", "id": "reaction_10326334", "reactome": "R-XTR-2172678", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326327", "species_113671", "species_113685" ], "products": [ "species_29478", "species_10326331", "species_159942", "species_159939" ], "modifiers": [ [ "species_10326327", "catalyst" ] ], "additional_components": [ "species_435347", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8RKR7", "ENSXETG00000035354", "species_435347", "species_435347", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10326658": { "compartment": "compartment_7660", "id": "reaction_10326658", "reactome": "R-XTR-2301205", "name": "SETD8 monomethylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10326331" ], "products": [ "species_77502", "species_10326327" ], "modifiers": [ [ "species_10326655", "catalyst" ] ], "additional_components": [ "A0A6I8RKR7", "ENSXETG00000035354", "species_435347", "species_435347", "A0A6I8RKR7", "ENSXETG00000035354", "ENSXETT00000012803" ] }, "reaction_10326218": { "compartment": "compartment_7660", "id": "reaction_10326218", "reactome": "R-XTR-2168079", "name": "MASTL (GWL) phosphorylates ARPP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10326205" ], "products": [ "species_113582", "species_10326208" ], "modifiers": [ [ "species_10326215", "catalyst" ] ], "additional_components": [ "ENSXETG00000027097", "ENSXETG00000027097", "ENSXETG00000018741" ] }, "reaction_10326837": { "compartment": "compartment_7660", "id": "reaction_10326837", "reactome": "R-XTR-2430535", "name": "MASTL phosphorylates ENSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10326832" ], "products": [ "species_113582", "species_10326835" ], "modifiers": [ [ "species_10326215", "catalyst" ] ], "additional_components": [ "ENSXETT00000056121", "ENSXETT00000056121", "ENSXETG00000018741" ] }, "reaction_10337987": { "compartment": "compartment_70101", "id": "reaction_10337987", "reactome": "R-XTR-9647746", "name": "EML4 trimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337983" ], "products": [ "species_10337985" ], "modifiers": [], "additional_components": [ "ENSXETG00000006002", "Q6DIP5", "ENSXETG00000006002" ] }, "reaction_10313138": { "compartment": "compartment_7660", "id": "reaction_10313138", "reactome": "R-XTR-163010", "name": "Down Regulation of Emi1 through Phosphorylation of Emi1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10313127" ], "products": [ "species_113582", "species_10313130" ], "modifiers": [ [ "species_10313135", "catalyst" ] ], "additional_components": [ "ENSXETG00000018545", "ENSXETG00000018545", "ENSXETT00000022754" ] }, "reaction_10337822": { "compartment": "compartment_70101", "id": "reaction_10337822", "reactome": "R-XTR-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9624879", "species_10337818" ], "products": [ "species_10337820" ], "modifiers": [], "additional_components": [ "Q6GL85", "ENSXETG00000027832", "species_29438", "Q6GL85", "ENSXETG00000027832", "species_29438" ] }, "reaction_10313996": { "compartment": "compartment_13231", "id": "reaction_10313996", "reactome": "R-XTR-187506", "name": "Translocation of p27 to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313992" ], "products": [ "species_10313994" ], "modifiers": [], "additional_components": [ "ENSXETG00000038125", "ENSXETG00000038125" ] }, "reaction_10314011": { "compartment": "compartment_7660", "id": "reaction_10314011", "reactome": "R-XTR-187520", "name": "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314003", "species_29358" ], "products": [ "species_113582", "species_10314008" ], "modifiers": [ [ "species_10314003", "catalyst" ] ], "additional_components": [ "A0A6I8SFF7", "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10313473": { "compartment": "compartment_70101", "id": "reaction_10313473", "reactome": "R-XTR-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311363", "species_10313428" ], "products": [ "species_10313471" ], "modifiers": [], "additional_components": [ "ENSXETT00000046130", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10313488": { "compartment": "compartment_13231", "id": "reaction_10313488", "reactome": "R-XTR-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313471" ], "products": [ "species_10313486" ], "modifiers": [], "additional_components": [ "F6T0J1", "ENSXETT00000046130", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10314032": { "compartment": "compartment_7660", "id": "reaction_10314032", "reactome": "R-XTR-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10311391" ], "products": [ "species_113582", "species_10312634" ], "modifiers": [ [ "species_10314001", "catalyst" ] ], "additional_components": [ "ENSXETG00000031493", "ENSXETG00000031493", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10314018": { "compartment": "compartment_7660", "id": "reaction_10314018", "reactome": "R-XTR-187916", "name": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10314013" ], "products": [ "species_113582", "species_10314015" ], "modifiers": [ [ "species_10314013", "catalyst" ] ], "additional_components": [ "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125" ] }, "reaction_10311361": { "compartment": "compartment_7660", "id": "reaction_10311361", "reactome": "R-XTR-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311355" ], "products": [ "species_10311333", "species_10311353", "species_10311359", "species_10311341" ], "modifiers": [], "additional_components": [ "Q561P5", "ENSXETG00000000253", "Q6GL41", "ENSXETG00000004854", "Q6DIH3", "ENSXETG00000002059", "Q28BS0", "ENSXETG00000021701", "Q6NX31", "ENSXETT00000074596", "Q6P1V8", "ENSXETG00000014891", "ENSXETG00000021701", "ENSXETG00000002059", "Q6GL41", "ENSXETG00000004854", "Q6NX31", "ENSXETT00000074596", "Q6P1V8", "ENSXETG00000014891", "ENSXETG00000000253" ] }, "reaction_10338031": { "compartment": "compartment_70101", "id": "reaction_10338031", "reactome": "R-XTR-9659820", "name": "RB1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338029" ], "products": [ "species_10311367" ], "modifiers": [], "additional_components": [ "ENSXETG00000031493", "ENSXETG00000031493" ] }, "reaction_10322470": { "compartment": "compartment_7660", "id": "reaction_10322470", "reactome": "R-XTR-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322466", "species_10313486" ], "products": [ "species_10322468" ], "modifiers": [], "additional_components": [ "ENSXETT00000008804", "F6T0J1", "ENSXETT00000046130", "F6T0J1", "ENSXETT00000046130", "F6UBS5", "ENSXETT00000008804" ] }, "reaction_10326109": { "compartment": "compartment_12045", "id": "reaction_10326109", "reactome": "R-XTR-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10326106", "catalyst" ] ], "additional_components": [ "A0A6I8SJ30", "ENSXETG00000038590", "A0A6I8PUP3", "ENSXETG00000033706", "F6W5W2", "ENSXETT00000042586", "A4IGV4", "ENSXETT00000061279" ] }, "reaction_10326121": { "compartment": "compartment_12045", "id": "reaction_10326121", "reactome": "R-XTR-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10326118", "catalyst" ] ], "additional_components": [ "A0A6I8SJ30", "ENSXETG00000038590", "F6W5W2", "ENSXETT00000042586", "A4IGV4", "ENSXETT00000061279" ] }, "reaction_10326104": { "compartment": "compartment_12045", "id": "reaction_10326104", "reactome": "R-XTR-2161795", "name": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2161639" ], "modifiers": [ [ "species_10326101", "catalyst" ] ], "additional_components": [ "CHEBI:63995", "CHEBI:63994", "CHEBI:63579", "A0A6I8SJ30", "ENSXETG00000038590", "A4IGV4", "ENSXETT00000061279" ] }, "reaction_10316618": { "compartment": "compartment_70101", "id": "reaction_10316618", "reactome": "R-XTR-264444", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316611", "species_10312116" ], "products": [ "species_10316615" ], "modifiers": [ [ "species_10316611", "catalyst" ] ], "additional_components": [ "ENSXETG00000009192", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8RXS2", "ENSXETG00000009192", "ENSXETG00000009192" ] }, "reaction_10316613": { "compartment": "compartment_13231", "id": "reaction_10316613", "reactome": "R-XTR-264418", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316609" ], "products": [ "species_10316611" ], "modifiers": [], "additional_components": [ "ENSXETG00000009192", "ENSXETG00000009192" ] }, "reaction_10320461": { "compartment": "compartment_17963", "id": "reaction_10320461", "reactome": "R-XTR-914012", "name": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320438" ], "products": [ "species_10320454", "species_205687" ], "modifiers": [ [ "species_10320458", "catalyst" ] ], "additional_components": [ "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "ENSXETG00000032293" ] }, "reaction_10320365": { "compartment": "compartment_17963", "id": "reaction_10320365", "reactome": "R-XTR-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10320292" ], "products": [ "species_10320363", "species_205687" ], "modifiers": [], "additional_components": [ "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522" ] }, "reaction_10320383": { "compartment": "compartment_17963", "id": "reaction_10320383", "reactome": "R-XTR-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320292" ], "products": [ "species_205687", "species_10320381" ], "modifiers": [], "additional_components": [ "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8R3H8", "ENSXETG00000039522" ] }, "reaction_10320479": { "compartment": "compartment_17963", "id": "reaction_10320479", "reactome": "R-XTR-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10320292" ], "products": [ "species_205687", "species_10320477" ], "modifiers": [], "additional_components": [ "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8R3H8", "ENSXETG00000039522" ] }, "reaction_10331400": { "compartment": "compartment_20699", "id": "reaction_10331400", "reactome": "R-XTR-5694487", "name": "A4GNT transfers GlcNAc to core 2 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320454" ], "products": [ "species_10331393", "species_205687" ], "modifiers": [ [ "species_10331397", "catalyst" ] ], "additional_components": [ "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8R3H8", "ENSXETG00000039522", "ENSXETG00000037302" ] }, "reaction_10320347": { "compartment": "compartment_17963", "id": "reaction_10320347", "reactome": "R-XTR-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320292" ], "products": [ "species_205687", "species_10320345" ], "modifiers": [], "additional_components": [ "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8QTA8", "ENSXETG00000018869" ] }, "reaction_10320327": { "compartment": "compartment_20699", "id": "reaction_10320327", "reactome": "R-XTR-913675", "name": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10320276" ], "products": [ "species_10320292", "species_205687" ], "modifiers": [ [ "species_10320324", "catalyst" ] ], "additional_components": [ "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "Q6DJR8", "ENSXETG00000040522", "A0A6I8SNY2", "ENSXETG00000040522", "F6VQB1", "ENSXETT00000045011", "F6R8Z5", "ENSXETT00000046964" ] }, "reaction_10332295": { "compartment": "compartment_20699", "id": "reaction_10332295", "reactome": "R-XTR-6786012", "name": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10320454" ], "products": [ "species_10332290", "species_742343" ], "modifiers": [ [ "species_10332292", "catalyst" ] ], "additional_components": [ "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "ENSXETG00000040380" ] }, "reaction_10320422": { "compartment": "compartment_20699", "id": "reaction_10320422", "reactome": "R-XTR-914010", "name": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320292" ], "products": [ "species_205687", "species_10320399" ], "modifiers": [ [ "species_10320419", "catalyst" ] ], "additional_components": [ "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8SXK5", "ENSXETG00000040687", "Q6P3P5", "ENSXETT00000055015" ] }, "reaction_10320497": { "compartment": "compartment_20699", "id": "reaction_10320497", "reactome": "R-XTR-914018", "name": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320399" ], "products": [ "species_205687", "species_10320495" ], "modifiers": [ [ "species_10320458", "catalyst" ] ], "additional_components": [ "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "ENSXETG00000032293" ] }, "reaction_10316180": { "compartment": "compartment_7660", "id": "reaction_10316180", "reactome": "R-XTR-211178", "name": "Phosphorylated FOXO1A is excluded from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315552" ], "products": [ "species_10316178" ], "modifiers": [], "additional_components": [ "ENSXETT00000101788", "ENSXETT00000101788" ] }, "reaction_10338106": { "compartment": "compartment_70101", "id": "reaction_10338106", "reactome": "R-XTR-9680443", "name": "ROCK1,2 bind ROCKi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9686558", "species_10317786" ], "products": [ "species_10317790" ], "modifiers": [], "additional_components": [ "ENSXETG00000023782", "A0A6I8Q6H0", "ENSXETG00000023782" ] }, "reaction_10317792": { "compartment": "compartment_70101", "id": "reaction_10317792", "reactome": "R-XTR-419049", "name": "ROCK activation by RHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317786", "species_10317689" ], "products": [ "species_10317788" ], "modifiers": [ [ "species_10317790", "inhibitor" ] ], "additional_components": [ "ENSXETG00000023782", "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8Q6H0", "ENSXETG00000023782", "A0A6I8Q6H0", "ENSXETG00000023782" ] }, "reaction_10336907": { "compartment": "compartment_5460", "id": "reaction_10336907", "reactome": "R-XTR-8952903", "name": "ADPRHL2 hydrolyses poly(ADP-ribose)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8952909", "species_113521" ], "products": [ "species_8952909", "species_8952905" ], "modifiers": [ [ "species_10336904", "catalyst" ] ], "additional_components": [ "species_8952905", "species_8952905", "ENSXETG00000004374" ] }, "reaction_10312814": { "compartment": "compartment_70101", "id": "reaction_10312814", "reactome": "R-XTR-139905", "name": "Translocation of activated BAD protein to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312810" ], "products": [ "species_10312812" ], "modifiers": [], "additional_components": [ "ENSXETG00000031875", "ENSXETG00000031875" ] }, "reaction_10312808": { "compartment": "compartment_70101", "id": "reaction_10312808", "reactome": "R-XTR-139899", "name": "Sequestration of BAD protein by 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312790", "species_10312804" ], "products": [ "species_10312806" ], "modifiers": [], "additional_components": [ "ENSXETG00000031875", "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830", "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830", "A0A6I8PXS6", "ENSXETG00000031875" ] }, "reaction_10312632": { "compartment": "compartment_7660", "id": "reaction_10312632", "reactome": "R-XTR-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312624", "species_10312628" ], "products": [ "species_10312630" ], "modifiers": [], "additional_components": [ "ENSXETG00000024742", "ENSXETT00000049621", "F7CLE9", "ENSXETT00000049621", "Q6GLD8", "ENSXETG00000024742" ] }, "reaction_10328189": { "compartment": "compartment_876", "id": "reaction_10328189", "reactome": "R-XTR-3781943", "name": "WLS:WNT complex is internalized for maturation into exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327498" ], "products": [ "species_10328169" ], "modifiers": [], "additional_components": [ "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930", "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930" ] }, "reaction_10327518": { "compartment": "compartment_171062", "id": "reaction_10327518", "reactome": "R-XTR-3247847", "name": "WLS is endocytosed to the early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327484" ], "products": [ "species_10327516" ], "modifiers": [], "additional_components": [ "ENSXETG00000012387", "ENSXETG00000012387" ] }, "reaction_10327512": { "compartment": "compartment_984", "id": "reaction_10327512", "reactome": "R-XTR-3247843", "name": "secretion of WNT ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327498" ], "products": [ "species_10327510", "species_10327484" ], "modifiers": [], "additional_components": [ "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930", "A0A6I8PXW7", "ENSXETG00000031623", "A0A6I8PX82", "ENSXETG00000011173", "A0A6I8QGQ0", "ENSXETG00000039930", "B2GUT4", "ENSXETT00000042046", "A0A6I8R7P2", "ENSXETG00000031217", "ENSXETG00000012387" ] }, "reaction_10328187": { "compartment": "compartment_383505", "id": "reaction_10328187", "reactome": "R-XTR-3781941", "name": "WNTs are secreted in exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328169" ], "products": [ "species_10328185" ], "modifiers": [], "additional_components": [ "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930", "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930" ] }, "reaction_10327482": { "compartment": "compartment_20699", "id": "reaction_10327482", "reactome": "R-XTR-3247840", "name": "WLS binds WNT ligands in the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327472", "species_10327478" ], "products": [ "species_10327480" ], "modifiers": [], "additional_components": [ "A0A6I8QGQ0", "ENSXETG00000039930", "ENSXETG00000012387", "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930" ] }, "reaction_10327514": { "compartment": "compartment_20699", "id": "reaction_10327514", "reactome": "R-XTR-3247844", "name": "WNT ligands traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327480" ], "products": [ "species_10327498" ], "modifiers": [], "additional_components": [ "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930", "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930" ] }, "reaction_10327474": { "compartment": "compartment_17963", "id": "reaction_10327474", "reactome": "R-XTR-3247837", "name": "WNT ligands traffic to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327460" ], "products": [ "species_10327472" ], "modifiers": [], "additional_components": [ "A0A6I8QGQ0", "ENSXETG00000039930", "A0A6I8QGQ0", "ENSXETG00000039930" ] }, "reaction_10312702": { "compartment": "compartment_17906", "id": "reaction_10312702", "reactome": "R-XTR-114284", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312698" ], "products": [ "species_10312660" ], "modifiers": [ [ "species_10312700", "catalyst" ] ], "additional_components": [ "Q6PBF4", "ENSXETT00000049267", "Q640U4", "ENSXETT00000018532", "Q640U4", "ENSXETT00000018532", "Q6PBF4", "ENSXETT00000049267", "A0A6I8QFQ5", "ENSXETG00000038338", "F6TEC3", "ENSXETT00000031936" ] }, "reaction_10337835": { "compartment": "compartment_70101", "id": "reaction_10337835", "reactome": "R-XTR-9627106", "name": "SMAC (DIABLO) forms dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312709" ], "products": [ "species_10337828" ], "modifiers": [], "additional_components": [ "ENSXETT00000008194", "Q0IJ31", "ENSXETT00000008194" ] }, "reaction_10312711": { "compartment": "compartment_17906", "id": "reaction_10312711", "reactome": "R-XTR-114307", "name": "Release of SMAC (DIABLO) from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312707" ], "products": [ "species_10312709" ], "modifiers": [ [ "species_10312700", "catalyst" ] ], "additional_components": [ "ENSXETT00000008194", "ENSXETT00000008194", "A0A6I8QFQ5", "ENSXETG00000038338", "F6TEC3", "ENSXETT00000031936" ] }, "reaction_10334049": { "compartment": "compartment_70101", "id": "reaction_10334049", "reactome": "R-XTR-6805507", "name": "APAF1 binds AVEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312666", "species_10334045" ], "products": [ "species_10334047" ], "modifiers": [], "additional_components": [ "A0A6I8RCL3", "ENSXETG00000006695", "species_29370", "ENSXETG00000017866", "A0A6I8PLL4", "ENSXETG00000017866", "A0A6I8RCL3", "ENSXETG00000006695", "species_29370" ] }, "reaction_10312672": { "compartment": "compartment_70101", "id": "reaction_10312672", "reactome": "R-XTR-114254", "name": "CYCS binds to APAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10312660", "species_10312666" ], "products": [ "species_29370", "species_10312670" ], "modifiers": [], "additional_components": [ "Q640U4", "ENSXETT00000018532", "Q6PBF4", "ENSXETT00000049267", "A0A6I8RCL3", "ENSXETG00000006695", "species_29370", "A0A6I8RCL3", "ENSXETG00000006695", "species_113593", "Q640U4", "ENSXETT00000018532", "Q6PBF4", "ENSXETT00000049267" ] }, "reaction_10337832": { "compartment": "compartment_70101", "id": "reaction_10337832", "reactome": "R-XTR-9627104", "name": "XIAP binds CASP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312650", "species_10329609" ], "products": [ "species_10337826" ], "modifiers": [ [ "species_10337830", "inhibitor" ] ], "additional_components": [ "A0A6I8PZK4", "ENSXETG00000030678", "ENSXETT00000035327", "Q5BKL8", "ENSXETT00000035327", "A0A6I8PZK4", "ENSXETG00000030678", "Q0IJ31", "ENSXETT00000008194", "Q5BKL8", "ENSXETT00000035327", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10337839": { "compartment": "compartment_70101", "id": "reaction_10337839", "reactome": "R-XTR-9627350", "name": "SMAC (DIABLO) binds XIAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337828", "species_10329609" ], "products": [ "species_10337837" ], "modifiers": [], "additional_components": [ "Q0IJ31", "ENSXETT00000008194", "ENSXETT00000035327", "Q5BKL8", "ENSXETT00000035327", "Q0IJ31", "ENSXETT00000008194" ] }, "reaction_10328555": { "compartment": "compartment_12045", "id": "reaction_10328555", "reactome": "R-XTR-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419981", "species_29364" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10328552", "catalyst" ] ], "additional_components": [ "ENSXETG00000021063" ] }, "reaction_10336283": { "compartment": "compartment_70101", "id": "reaction_10336283", "reactome": "R-XTR-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869353", "species_113592" ], "products": [ "species_1132084", "species_29360" ], "modifiers": [ [ "species_10314359", "catalyst" ] ], "additional_components": [ "species_109496", "A4IH61", "ENSXETT00000027403" ] }, "reaction_10314362": { "compartment": "compartment_70101", "id": "reaction_10314362", "reactome": "R-XTR-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_1132084" ], "modifiers": [ [ "species_10314359", "catalyst" ] ], "additional_components": [ "species_109496", "A4IH61", "ENSXETT00000027403" ] }, "reaction_10335877": { "compartment": "compartment_70101", "id": "reaction_10335877", "reactome": "R-XTR-8869633", "name": "NMRK1 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_8869353", "species_70106", "species_29370" ], "modifiers": [ [ "species_10335871", "catalyst" ] ], "additional_components": [ "ENSXETG00000031505" ] }, "reaction_10329621": { "compartment": "compartment_70101", "id": "reaction_10329621", "reactome": "R-XTR-5359451", "name": "NNMT transfers CH3 from SAM to NAM to form MNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197277", "species_71284" ], "products": [ "species_549282", "species_71285" ], "modifiers": [ [ "species_10313553", "catalyst" ] ], "additional_components": [ "ENSXETG00000028049" ] }, "reaction_10336214": { "compartment": "compartment_70101", "id": "reaction_10336214", "reactome": "R-XTR-8938073", "name": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938276", "species_29360" ], "products": [ "species_197277", "species_8938282" ], "modifiers": [ [ "species_10336211", "catalyst" ] ], "additional_components": [ "A0A1B8XUU3", "ENSXETT00000078735", "F6YMQ2", "ENSXETT00000038413" ] }, "reaction_10334496": { "compartment": "compartment_5460", "id": "reaction_10334496", "reactome": "R-XTR-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10334493", "catalyst" ] ], "additional_components": [ "A0A5S6NBZ0", "ENSXETG00000020391" ] }, "reaction_10335874": { "compartment": "compartment_70101", "id": "reaction_10335874", "reactome": "R-XTR-8869606", "name": "NMRK1 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10335871", "catalyst" ] ], "additional_components": [ "ENSXETG00000031505" ] }, "reaction_10336978": { "compartment": "compartment_5460", "id": "reaction_10336978", "reactome": "R-XTR-8955030", "name": "NADK2 dimer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113526" ], "products": [ "species_113581", "species_113563", "species_113529" ], "modifiers": [ [ "species_10336975", "catalyst" ] ], "additional_components": [ "Q08CZ6", "ENSXETT00000010405" ] }, "reaction_10314353": { "compartment": "compartment_70101", "id": "reaction_10314353", "reactome": "R-XTR-196955", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29386" ], "products": [ "species_73524", "species_76577" ], "modifiers": [ [ "species_10314350", "catalyst" ] ], "additional_components": [ "A0A6I8RYX5", "ENSXETG00000030043" ] }, "reaction_10315543": { "compartment": "compartment_70616", "id": "reaction_10315543", "reactome": "R-XTR-199216", "name": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194" ], "products": [ "species_29374" ], "modifiers": [ [ "species_10315540", "catalyst" ] ], "additional_components": [ "ENSXETG00000030903" ] }, "reaction_10327160": { "compartment": "compartment_70101", "id": "reaction_10327160", "reactome": "R-XTR-2993802", "name": "HLCS biotinylates PC:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_199207", "species_10327148" ], "products": [ "species_111294", "species_10327153", "species_76577" ], "modifiers": [ [ "species_10327157", "catalyst" ] ], "additional_components": [ "A0A6I8QW74", "ENSXETG00000008415", "CHEBI:29035", "A0A6I8QW74", "ENSXETG00000008415", "CHEBI:29035", "ENSXETG00000013028" ] }, "reaction_10327703": { "compartment": "compartment_70101", "id": "reaction_10327703", "reactome": "R-XTR-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327153" ], "products": [ "species_10327240" ], "modifiers": [], "additional_components": [ "A0A6I8QW74", "ENSXETG00000008415", "CHEBI:29035", "CHEBI:29035", "A0A6I8QW74", "ENSXETG00000008415" ] }, "reaction_10331341": { "compartment": "compartment_70616", "id": "reaction_10331341", "reactome": "R-XTR-5694137", "name": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_5693984", "species_113521" ], "products": [ "species_200671", "species_379732" ], "modifiers": [ [ "species_10331338", "catalyst" ] ], "additional_components": [ "A0A6I8RGC7", "ENSXETG00000017162" ] }, "reaction_10315636": { "compartment": "compartment_70101", "id": "reaction_10315636", "reactome": "R-XTR-200735", "name": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_197969" ], "products": [ "species_29424", "species_200739" ], "modifiers": [ [ "species_10311706", "catalyst" ] ], "additional_components": [ "A0A6I8QRM0", "ENSXETG00000005754" ] }, "reaction_10334535": { "compartment": "compartment_70101", "id": "reaction_10334535", "reactome": "R-XTR-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111353", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_197969" ], "modifiers": [ [ "species_10334532", "catalyst" ] ], "additional_components": [ "Q63ZT8", "ENSXETT00000084678" ] }, "reaction_10315634": { "compartment": "compartment_70101", "id": "reaction_10315634", "reactome": "R-XTR-200651", "name": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_200739" ], "products": [ "species_200736", "species_197969" ], "modifiers": [ [ "species_10311706", "catalyst" ] ], "additional_components": [ "A0A6I8QRM0", "ENSXETG00000005754" ] }, "reaction_10320707": { "compartment": "compartment_70101", "id": "reaction_10320707", "reactome": "R-XTR-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947539", "species_111707" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10320704", "catalyst" ] ], "additional_components": [ "ENSXETG00000038002" ] }, "reaction_10327276": { "compartment": "compartment_70101", "id": "reaction_10327276", "reactome": "R-XTR-3149494", "name": "MMACHC:cob(II)alamin binds MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327268", "species_10327246" ], "products": [ "species_10327270" ], "modifiers": [], "additional_components": [ "ENSXETG00000004524", "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "A0A6I8Q401", "ENSXETG00000004524" ] }, "reaction_10327279": { "compartment": "compartment_70101", "id": "reaction_10327279", "reactome": "R-XTR-3149519", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10327244", "species_3149505" ], "products": [ "species_29366", "species_10327246", "species_1130611" ], "modifiers": [ [ "species_10327244", "catalyst" ] ], "additional_components": [ "ENSXETG00000003502", "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "ENSXETG00000003502" ] }, "reaction_10327274": { "compartment": "compartment_70101", "id": "reaction_10327274", "reactome": "R-XTR-3149492", "name": "cob(II)alamin dissociates from MMACHC:MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327270" ], "products": [ "species_3149479", "species_10327272" ], "modifiers": [], "additional_components": [ "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "A0A6I8Q401", "ENSXETG00000004524", "A0A6I8Q1G4", "ENSXETG00000003502", "A0A6I8Q401", "ENSXETG00000004524" ] }, "reaction_10327290": { "compartment": "compartment_5460", "id": "reaction_10327290", "reactome": "R-XTR-3159253", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159260", "species_113593" ], "products": [ "species_3159274", "species_3159297" ], "modifiers": [ [ "species_10327287", "catalyst" ] ], "additional_components": [ "A0A6I8T0P0", "ENSXETG00000040875" ] }, "reaction_10327249": { "compartment": "compartment_70101", "id": "reaction_10327249", "reactome": "R-XTR-3095889", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000241", "species_70106", "species_29364", "species_10327244" ], "products": [ "species_29366", "species_10327246" ], "modifiers": [ [ "species_10327244", "catalyst" ] ], "additional_components": [ "ENSXETG00000003502", "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "ENSXETG00000003502" ] }, "reaction_10327281": { "compartment": "compartment_70101", "id": "reaction_10327281", "reactome": "R-XTR-3149563", "name": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327270" ], "products": [ "species_3149564", "species_10327272" ], "modifiers": [], "additional_components": [ "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "A0A6I8Q401", "ENSXETG00000004524", "A0A6I8Q1G4", "ENSXETG00000003502", "A0A6I8Q401", "ENSXETG00000004524" ] }, "reaction_10327186": { "compartment": "compartment_70101", "id": "reaction_10327186", "reactome": "R-XTR-3000238", "name": "LMBRD1 transports lysosomal Cbl to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000239" ], "products": [ "species_3000241" ], "modifiers": [ [ "species_10327183", "catalyst" ] ], "additional_components": [ "ENSXETT00000025716" ] }, "reaction_10327301": { "compartment": "compartment_70101", "id": "reaction_10327301", "reactome": "R-XTR-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965131" ], "products": [ "species_3204324", "species_29408" ], "modifiers": [ [ "species_10327298", "catalyst" ] ], "additional_components": [ "A0A6I8RQ40", "ENSXETG00000039500", "CHEBI:33722", "CHEBI:44074", "species_113596" ] }, "reaction_10314427": { "compartment": "compartment_70101", "id": "reaction_10314427", "reactome": "R-XTR-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497805", "species_10314424" ], "products": [ "species_10314422", "species_198816" ], "modifiers": [ [ "species_10314424", "catalyst" ] ], "additional_components": [ "F6WBG7", "ENSXETT00000038708", "species_189444", "species_917955", "F6WBG7", "ENSXETT00000038708", "F6WBG7", "ENSXETT00000038708", "species_189444" ] }, "reaction_10314434": { "compartment": "compartment_876", "id": "reaction_10314434", "reactome": "R-XTR-198870", "name": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198836", "species_74113" ], "products": [ "species_83910", "species_198816" ], "modifiers": [ [ "species_10314431", "catalyst" ] ], "additional_components": [ "ENSXETT00000099885" ] }, "reaction_10326701": { "compartment": "compartment_70101", "id": "reaction_10326701", "reactome": "R-XTR-2395764", "name": "atREs binds to nascent CM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326405", "species_2534423" ], "products": [ "species_10326407" ], "modifiers": [], "additional_components": [ "species_171126", "species_171142", "A0A6I8RKY6", "ENSXETG00000026768", "A0A6I8PU04", "ENSXETG00000033423", "species_216762", "species_163579", "A0A6I8SNZ3", "ENSXETG00000038088", "Q08BT8", "ENSXETT00000008146", "species_2534407", "CHEBI:70762", "CHEBI:70760", "CHEBI:70761", "species_2534407", "CHEBI:70762", "CHEBI:70760", "CHEBI:70761", "species_171126", "species_171142", "A0A6I8RKY6", "ENSXETG00000026768", "A0A6I8PU04", "ENSXETG00000033423", "species_216762", "species_163579", "A0A6I8SNZ3", "ENSXETG00000038088", "Q08BT8", "ENSXETT00000008146" ] }, "reaction_10326780": { "compartment": "compartment_984", "id": "reaction_10326780", "reactome": "R-XTR-2404135", "name": "RBP4 binds atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395761", "species_10326766" ], "products": [ "species_10326768" ], "modifiers": [], "additional_components": [ "ENSXETT00000008077", "F6UH11", "ENSXETT00000008077", "species_30209" ] }, "reaction_10326411": { "compartment": "compartment_70101", "id": "reaction_10326411", "reactome": "R-XTR-2187332", "name": "Cytosolic CMs translocate to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326407" ], "products": [ "species_10326409" ], "modifiers": [], "additional_components": [ "species_2534407", "CHEBI:70762", "CHEBI:70760", "CHEBI:70761", "species_171126", "species_171142", "A0A6I8RKY6", "ENSXETG00000026768", "A0A6I8PU04", "ENSXETG00000033423", "species_216762", "species_163579", "A0A6I8SNZ3", "ENSXETG00000038088", "Q08BT8", "ENSXETT00000008146", "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "CHEBI:70760", "species_2534407", "CHEBI:70762", "CHEBI:70761", "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "A0A6I8SNZ3", "ENSXETG00000038088", "Q08BT8", "ENSXETT00000008146", "species_216762" ] }, "reaction_10320762": { "compartment": "compartment_984", "id": "reaction_10320762", "reactome": "R-XTR-975593", "name": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_975591" ], "products": [ "species_975590", "species_426576" ], "modifiers": [ [ "species_10314239", "catalyst" ] ], "additional_components": [ "F6ZWX1", "ENSXETT00000007508" ] }, "reaction_10326778": { "compartment": "compartment_984", "id": "reaction_10326778", "reactome": "R-XTR-2404134", "name": "RBP4:atROL binds TTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326768", "species_10326774" ], "products": [ "species_10326776" ], "modifiers": [], "additional_components": [ "F6UH11", "ENSXETT00000008077", "species_30209", "A4QNN7", "ENSXETT00000010246", "A4QNN7", "ENSXETT00000010246", "F6UH11", "ENSXETT00000008077", "species_30209" ] }, "reaction_10334456": { "compartment": "compartment_17957", "id": "reaction_10334456", "reactome": "R-XTR-6806674", "name": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806891", "species_6806657" ], "products": [ "species_6806362", "species_6806656" ], "modifiers": [ [ "species_10334453", "catalyst" ] ], "additional_components": [ "ENSXETG00000017414" ] }, "reaction_10323409": { "compartment": "compartment_70101", "id": "reaction_10323409", "reactome": "R-XTR-1497869", "name": "Salvage - Sepiapterin is reduced to BH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1497811", "species_29364" ], "products": [ "species_1497857", "species_29366" ], "modifiers": [ [ "species_10323229", "catalyst" ] ], "additional_components": [ "A0A6I8PWL6", "ENSXETG00000033127" ] }, "reaction_10323232": { "compartment": "compartment_70101", "id": "reaction_10323232", "reactome": "R-XTR-1475414", "name": "PTHP is reduced to BH4 by sepiapterin reductase (SPR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474179", "species_29364" ], "products": [ "species_29870", "species_29366" ], "modifiers": [ [ "species_10323229", "catalyst" ] ], "additional_components": [ "A0A6I8PWL6", "ENSXETG00000033127" ] }, "reaction_10323123": { "compartment": "compartment_70101", "id": "reaction_10323123", "reactome": "R-XTR-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10323120", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8S775", "ENSXETG00000034891" ] }, "reaction_10327167": { "compartment": "compartment_5460", "id": "reaction_10327167", "reactome": "R-XTR-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189444", "species_2162257", "species_113521" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10327164", "catalyst" ] ], "additional_components": [ "ENSXETG00000033101" ] }, "reaction_10314072": { "compartment": "compartment_70101", "id": "reaction_10314072", "reactome": "R-XTR-189425", "name": "UROD decarboxylates URO3 to COPRO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189407" ], "products": [ "species_189455", "species_113528" ], "modifiers": [ [ "species_10314069", "catalyst" ] ], "additional_components": [ "A0A6I8QYD9", "ENSXETG00000041183" ] }, "reaction_10314085": { "compartment": "compartment_70101", "id": "reaction_10314085", "reactome": "R-XTR-190141", "name": "ALAD binds to Pb2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190173", "species_10314078" ], "products": [ "species_10314083", "species_29426" ], "modifiers": [], "additional_components": [ "F7BED4", "ENSXETT00000050679", "species_29426", "F7BED4", "ENSXETT00000050679", "species_29426", "species_190173" ] }, "reaction_10314087": { "compartment": "compartment_70101", "id": "reaction_10314087", "reactome": "R-XTR-190182", "name": "UROD decarboxylates URO1 to COPRO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190157" ], "products": [ "species_113528", "species_190128" ], "modifiers": [ [ "species_10314069", "catalyst" ] ], "additional_components": [ "A0A6I8QYD9", "ENSXETG00000041183" ] }, "reaction_10314081": { "compartment": "compartment_70101", "id": "reaction_10314081", "reactome": "R-XTR-189439", "name": "ALAD condenses 2 dALAs to form PBG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189489" ], "products": [ "species_29356", "species_70106", "species_189464" ], "modifiers": [ [ "species_10314078", "catalyst" ] ], "additional_components": [ "F7BED4", "ENSXETT00000050679", "species_29426" ] }, "reaction_10338037": { "compartment": "compartment_70101", "id": "reaction_10338037", "reactome": "R-XTR-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338035" ], "products": [ "species_189386", "species_10313560" ], "modifiers": [], "additional_components": [ "A0A6I8S817", "ENSXETG00000036388", "species_189386", "ENSXETG00000036388" ] }, "reaction_10338039": { "compartment": "compartment_70101", "id": "reaction_10338039", "reactome": "R-XTR-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10313560" ], "products": [ "species_10338035" ], "modifiers": [], "additional_components": [ "ENSXETG00000036388", "A0A6I8S817", "ENSXETG00000036388", "species_189386" ] }, "reaction_10311500": { "compartment": "compartment_70101", "id": "reaction_10311500", "reactome": "R-XTR-70581", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_76213" ], "products": [ "species_29406", "species_29448" ], "modifiers": [ [ "species_10311497", "catalyst" ] ], "additional_components": [ "F6VWW1", "ENSXETT00000039920" ] }, "reaction_10332346": { "compartment": "compartment_70101", "id": "reaction_10332346", "reactome": "R-XTR-6787757", "name": "PXLP-K333-GADL1 decarboxylates acidic AAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787759" ], "products": [ "species_113528", "species_6787762" ], "modifiers": [ [ "species_10332343", "catalyst" ] ], "additional_components": [ "species_6787748", "species_29448", "CHEBI:17285", "species_73590", "species_1655445", "CHEBI:15891", "Q28D99", "ENSXETG00000014481" ] }, "reaction_10311511": { "compartment": "compartment_70101", "id": "reaction_10311511", "reactome": "R-XTR-70592", "name": "PXLP-K259-GOT1 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29448" ], "products": [ "species_29404", "species_76213" ], "modifiers": [ [ "species_10311497", "catalyst" ] ], "additional_components": [ "F6VWW1", "ENSXETT00000039920" ] }, "reaction_10331184": { "compartment": "compartment_70101", "id": "reaction_10331184", "reactome": "R-XTR-5691507", "name": "ASPA deacetylates NAA to acetate and L-aspartate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5691492" ], "products": [ "species_29416", "species_29448" ], "modifiers": [ [ "species_10331181", "catalyst" ] ], "additional_components": [ "species_29426", "Q28C61", "ENSXETG00000005789" ] }, "reaction_10336962": { "compartment": "compartment_5460", "id": "reaction_10336962", "reactome": "R-XTR-8954468", "name": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113553" ], "products": [ "species_29374", "species_8954466", "species_113529" ], "modifiers": [ [ "species_10336959", "catalyst" ] ], "additional_components": [ "ENSXETG00000002389" ] }, "reaction_10311532": { "compartment": "compartment_5460", "id": "reaction_10311532", "reactome": "R-XTR-70654", "name": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113585" ], "products": [ "species_31339", "species_113552" ], "modifiers": [ [ "species_10311529", "catalyst" ] ], "additional_components": [ "A0A6I8STU4", "ENSXETG00000040155" ] }, "reaction_10311513": { "compartment": "compartment_5460", "id": "reaction_10311513", "reactome": "R-XTR-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113521", "species_517495" ], "products": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "modifiers": [ [ "species_10311506", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29360", "species_113563", "species_113600", "species_73473", "Q5XGI4", "ENSXETT00000103326" ] }, "reaction_10332232": { "compartment": "compartment_5460", "id": "reaction_10332232", "reactome": "R-XTR-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10332229", "catalyst" ] ], "additional_components": [ "F7ALX3", "ENSXETT00000021260" ] }, "reaction_10311541": { "compartment": "compartment_5460", "id": "reaction_10311541", "reactome": "R-XTR-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10311538", "catalyst" ] ], "additional_components": [ "F7ALX3", "ENSXETT00000021260" ] }, "reaction_10311509": { "compartment": "compartment_5460", "id": "reaction_10311509", "reactome": "R-XTR-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "products": [ "species_113552", "species_113521", "species_517495" ], "modifiers": [ [ "species_10311506", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_113600", "species_73473", "species_29360", "species_113563", "Q5XGI4", "ENSXETT00000103326" ] }, "reaction_10336771": { "compartment": "compartment_70101", "id": "reaction_10336771", "reactome": "R-XTR-8942575", "name": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113592", "species_5691492" ], "products": [ "species_29370", "species_5693762" ], "modifiers": [ [ "species_10336766", "catalyst" ] ], "additional_components": [ "ENSXETG00000030755" ] }, "reaction_10311674": { "compartment": "compartment_70101", "id": "reaction_10311674", "reactome": "R-XTR-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_31365" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10311671", "catalyst" ] ], "additional_components": [ "species_198836", "species_435347", "F7AAG5", "ENSXETT00000008159" ] }, "reaction_10326051": { "compartment": "compartment_984", "id": "reaction_10326051", "reactome": "R-XTR-2160492", "name": "IL4I1:FAD oxidises L-Phe to kPPV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_351993", "species_352327" ], "products": [ "species_2022135", "species_351629", "species_2160466" ], "modifiers": [ [ "species_10326048", "catalyst" ] ], "additional_components": [ "A0A5S6N697", "ENSXETG00000031027", "species_113596" ] }, "reaction_10332252": { "compartment": "compartment_5460", "id": "reaction_10332252", "reactome": "R-XTR-6784423", "name": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784229" ], "products": [ "species_904849", "species_113557" ], "modifiers": [ [ "species_10332249", "catalyst" ] ], "additional_components": [ "Q5M8W9", "ENSXETT00000007453" ] }, "reaction_10332243": { "compartment": "compartment_5460", "id": "reaction_10332243", "reactome": "R-XTR-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10332240", "catalyst" ] ], "additional_components": [ "A0A6I8SGS7", "ENSXETG00000040955", "species_113596" ] }, "reaction_10334594": { "compartment": "compartment_17951", "id": "reaction_10334594", "reactome": "R-XTR-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_6810061" ], "products": [ "species_113575", "species_389843", "species_6810070" ], "modifiers": [ [ "species_10334591", "catalyst" ] ], "additional_components": [ "F6TSP3", "ENSXETT00000046108", "species_113596" ] }, "reaction_10311490": { "compartment": "compartment_5460", "id": "reaction_10311490", "reactome": "R-XTR-70555", "name": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113561", "species_29896" ], "products": [ "species_113548", "species_113581", "species_29676" ], "modifiers": [ [ "species_10311487", "catalyst" ], [ "species_30471", "catalyst" ] ], "additional_components": [ "ENSXETG00000006919" ] }, "reaction_10311481": { "compartment": "compartment_70101", "id": "reaction_10311481", "reactome": "R-XTR-70523", "name": "PXLP-K314-GPT transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29432" ], "products": [ "species_29404", "species_29398" ], "modifiers": [ [ "species_10311478", "catalyst" ] ], "additional_components": [ "Q28DB5", "ENSXETG00000007140" ] }, "reaction_10323908": { "compartment": "compartment_70101", "id": "reaction_10323908", "reactome": "R-XTR-1614654", "name": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352015", "species_174369" ], "products": [ "species_174390", "species_1614585" ], "modifiers": [ [ "species_10323905", "catalyst" ] ], "additional_components": [ "Q5M8Z0", "ENSXETT00000001133", "species_29426" ] }, "reaction_10331943": { "compartment": "compartment_70101", "id": "reaction_10331943", "reactome": "R-XTR-5696838", "name": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4789070", "species_174369" ], "products": [ "species_70106", "species_174390" ], "modifiers": [ [ "species_10331940", "catalyst" ] ], "additional_components": [ "species_29426", "Q5M8Z0", "ENSXETT00000001133" ] }, "reaction_10322223": { "compartment": "compartment_70101", "id": "reaction_10322223", "reactome": "R-XTR-1237096", "name": "Methylthio-ribose-P = Methylthio-ribulose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237165" ], "products": [ "species_1237107" ], "modifiers": [ [ "species_10322220", "catalyst" ] ], "additional_components": [ "ENSXETT00000047323" ] }, "reaction_10322232": { "compartment": "compartment_70101", "id": "reaction_10322232", "reactome": "R-XTR-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_1237155" ], "products": [ "species_29460", "species_1237122" ], "modifiers": [ [ "species_10322229", "catalyst" ] ], "additional_components": [ "species_435347", "Q6DIY2", "ENSXETT00000000659" ] }, "reaction_10322241": { "compartment": "compartment_70101", "id": "reaction_10322241", "reactome": "R-XTR-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1237176" ], "products": [ "species_29372", "species_70106", "species_1237155" ], "modifiers": [ [ "species_10322238", "catalyst" ] ], "additional_components": [ "Q28C69", "ENSXETG00000012582", "species_109496" ] }, "reaction_10334661": { "compartment": "compartment_70101", "id": "reaction_10334661", "reactome": "R-XTR-6814165", "name": "PXLP-K333-GADL1 decarboxylates CSA to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787748" ], "products": [ "species_1655445", "species_113528" ], "modifiers": [ [ "species_10332343", "catalyst" ] ], "additional_components": [ "Q28D99", "ENSXETG00000014481" ] }, "reaction_10311608": { "compartment": "compartment_70101", "id": "reaction_10311608", "reactome": "R-XTR-70906", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_34979" ], "products": [ "species_30158", "species_70106" ], "modifiers": [ [ "species_10311605", "catalyst" ] ], "additional_components": [ "ENSXETT00000046755" ] }, "reaction_10332309": { "compartment": "compartment_70101", "id": "reaction_10332309", "reactome": "R-XTR-6786245", "name": "CARNS1 transforms ATP, L-His, b-Ala to CARN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612", "species_113592", "species_73590" ], "products": [ "species_6786250", "species_29372", "species_29370" ], "modifiers": [ [ "species_10332306", "catalyst" ] ], "additional_components": [ "ENSXETG00000034643" ] }, "reaction_10311601": { "compartment": "compartment_70101", "id": "reaction_10311601", "reactome": "R-XTR-70903", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30721" ], "products": [ "species_34979" ], "modifiers": [ [ "species_10311598", "catalyst" ] ], "additional_components": [ "species_29360", "A0A6I8R5U8", "ENSXETG00000011543" ] }, "reaction_10336008": { "compartment": "compartment_5668575", "id": "reaction_10336008", "reactome": "R-XTR-8878581", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662670", "species_5668566" ], "products": [ "species_8878586", "species_5668574" ], "modifiers": [ [ "species_10336005", "catalyst" ] ], "additional_components": [ "ENSXETG00000012905" ] }, "reaction_10311617": { "compartment": "compartment_5460", "id": "reaction_10311617", "reactome": "R-XTR-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113556", "species_113521" ], "products": [ "species_113529", "species_508531", "species_29362" ], "modifiers": [ [ "species_10311614", "catalyst" ] ], "additional_components": [ "F7BQF6", "ENSXETT00000011316" ] }, "reaction_10336981": { "compartment": "compartment_5460", "id": "reaction_10336981", "reactome": "R-XTR-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_6784215" ], "products": [ "species_113590", "species_164934", "species_113521" ], "modifiers": [ [ "species_10332236", "catalyst" ] ], "additional_components": [ "ENSXETG00000040955" ] }, "reaction_10316697": { "compartment": "compartment_70101", "id": "reaction_10316697", "reactome": "R-XTR-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10316694", "catalyst" ] ], "additional_components": [ "ENSXETG00000039007" ] }, "reaction_10316699": { "compartment": "compartment_70101", "id": "reaction_10316699", "reactome": "R-XTR-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_353555", "species_76194" ], "modifiers": [ [ "species_10316694", "catalyst" ] ], "additional_components": [ "ENSXETG00000039007" ] }, "reaction_10316690": { "compartment": "compartment_70101", "id": "reaction_10316690", "reactome": "R-XTR-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10316687", "catalyst" ] ], "additional_components": [ "ENSXETG00000040919" ] }, "reaction_10311558": { "compartment": "compartment_70101", "id": "reaction_10311558", "reactome": "R-XTR-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10311555", "catalyst" ] ], "additional_components": [ "A0A6I8QKY2", "ENSXETG00000040919", "F6VJF3", "ENSXETT00000007603" ] }, "reaction_10311567": { "compartment": "compartment_5460", "id": "reaction_10311567", "reactome": "R-XTR-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10311564", "catalyst" ] ], "additional_components": [ "F7DXL6", "ENSXETT00000001790" ] }, "reaction_10311576": { "compartment": "compartment_5460", "id": "reaction_10311576", "reactome": "R-XTR-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70718", "species_113596" ], "products": [ "species_70799", "species_31649" ], "modifiers": [ [ "species_10311573", "catalyst" ] ], "additional_components": [ "species_113596", "F6VHN6", "ENSXETT00000035066" ] }, "reaction_10311592": { "compartment": "compartment_5460", "id": "reaction_10311592", "reactome": "R-XTR-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10311589", "catalyst" ] ], "additional_components": [ "ENSXETT00000033364" ] }, "reaction_10311585": { "compartment": "compartment_5460", "id": "reaction_10311585", "reactome": "R-XTR-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10311582", "catalyst" ] ], "additional_components": [ "Q5BKN8", "ENSXETT00000031684" ] }, "reaction_10311725": { "compartment": "compartment_70101", "id": "reaction_10311725", "reactome": "R-XTR-71286", "name": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_30401" ], "products": [ "species_29916", "species_70106", "species_71285" ], "modifiers": [ [ "species_10311722", "catalyst" ] ], "additional_components": [ "ENSXETG00000003703" ] }, "reaction_10311718": { "compartment": "compartment_17927", "id": "reaction_10311718", "reactome": "R-XTR-71275", "name": "arginine + glycine => ornithine + guanidoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113530", "species_113545" ], "products": [ "species_113543", "species_113586" ], "modifiers": [ [ "species_10311715", "catalyst" ] ], "additional_components": [ "Q6P832", "ENSXETT00000035125" ] }, "reaction_10332468": { "compartment": "compartment_5460", "id": "reaction_10332468", "reactome": "R-XTR-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_6798194", "species_113521" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10311612", "catalyst" ] ], "additional_components": [ "ENSXETT00000011316" ] }, "reaction_10311690": { "compartment": "compartment_70101", "id": "reaction_10311690", "reactome": "R-XTR-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_29970" ], "products": [ "species_34351", "species_29356", "species_29366" ], "modifiers": [ [ "species_10311687", "catalyst" ] ], "additional_components": [ "ENSXETT00000035436" ] }, "reaction_10311683": { "compartment": "compartment_70101", "id": "reaction_10311683", "reactome": "R-XTR-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29500", "species_29368" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10311680", "catalyst" ] ], "additional_components": [ "species_189444", "Q5EBG2", "ENSXETT00000048482" ] }, "reaction_10311699": { "compartment": "compartment_70101", "id": "reaction_10311699", "reactome": "R-XTR-71218", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30487" ], "products": [ "species_36027" ], "modifiers": [ [ "species_10311696", "catalyst" ] ], "additional_components": [ "Q6DIZ0", "ENSXETG00000015771", "species_435347" ] }, "reaction_10326790": { "compartment": "compartment_70101", "id": "reaction_10326790", "reactome": "R-XTR-2408524", "name": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5359016", "species_5357697" ], "products": [ "species_5357660", "species_29432", "species_5359011" ], "modifiers": [ [ "species_10326787", "catalyst" ] ], "additional_components": [ "Q5U4Q9", "ENSXETT00000026454" ] }, "reaction_10311709": { "compartment": "compartment_70101", "id": "reaction_10311709", "reactome": "R-XTR-71249", "name": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31503" ], "products": [ "species_31311", "species_29424" ], "modifiers": [ [ "species_10311706", "catalyst" ] ], "additional_components": [ "A0A6I8QRM0", "ENSXETG00000005754" ] }, "reaction_10311917": { "compartment": "compartment_70101", "id": "reaction_10311917", "reactome": "R-XTR-73632", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_83928" ], "products": [ "species_29370", "species_109366" ], "modifiers": [ [ "species_10311914", "catalyst" ] ], "additional_components": [ "A0A6I8SMB6", "ENSXETG00000001323" ] }, "reaction_10312345": { "compartment": "compartment_70101", "id": "reaction_10312345", "reactome": "R-XTR-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10312342", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_727810", "species_109402", "B1H116", "ENSXETT00000037794" ] }, "reaction_10311908": { "compartment": "compartment_70101", "id": "reaction_10311908", "reactome": "R-XTR-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500829" ], "products": [ "species_500430", "species_31633" ], "modifiers": [ [ "species_10311905", "catalyst" ] ], "additional_components": [ "CHEBI:15698", "CHEBI:17562", "CHEBI:16450", "CHEBI:16704", "species_29426", "A0A6I8SN57", "ENSXETG00000037611" ] }, "reaction_10311993": { "compartment": "compartment_70101", "id": "reaction_10311993", "reactome": "R-XTR-74241", "name": "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500173" ], "products": [ "species_500172", "species_31633" ], "modifiers": [ [ "species_10311990", "catalyst" ] ], "additional_components": [ "species_8857850", "CHEBI:17256", "CHEBI:28997", "species_83927", "ENSXETG00000003459" ] }, "reaction_10312600": { "compartment": "compartment_70101", "id": "reaction_10312600", "reactome": "R-XTR-112033", "name": "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_500244" ], "products": [ "species_29372", "species_500172" ], "modifiers": [ [ "species_10311999", "catalyst" ] ], "additional_components": [ "CHEBI:28542", "CHEBI:35425", "CHEBI:28997", "species_83927", "A0A6I8SRS9", "ENSXETG00000016932" ] }, "reaction_10312602": { "compartment": "compartment_70101", "id": "reaction_10312602", "reactome": "R-XTR-112034", "name": "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83956", "species_500244" ], "products": [ "species_29372", "species_500245" ], "modifiers": [ [ "species_10311999", "catalyst" ] ], "additional_components": [ "CHEBI:28542", "CHEBI:35425", "CHEBI:17172", "CHEBI:16750", "A0A6I8SRS9", "ENSXETG00000016932" ] }, "reaction_10312245": { "compartment": "compartment_70101", "id": "reaction_10312245", "reactome": "R-XTR-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76577" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10312242", "catalyst" ] ], "additional_components": [ "A0A6I8SRY8", "ENSXETG00000002009" ] }, "reaction_10311986": { "compartment": "compartment_70101", "id": "reaction_10311986", "reactome": "R-XTR-74215", "name": "guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_500259" ], "products": [ "species_111294", "species_500260" ], "modifiers": [ [ "species_10311983", "catalyst" ] ], "additional_components": [ "species_83956", "species_113599", "species_29602", "species_5696194", "A0A6I8SQB1", "ENSXETG00000019768", "species_109496" ] }, "reaction_10312364": { "compartment": "compartment_70101", "id": "reaction_10312364", "reactome": "R-XTR-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_6788778", "species_113592" ], "modifiers": [ [ "species_10312361", "catalyst" ] ], "additional_components": [ "species_29370", "CHEBI:28846", "CHEBI:16174", "CHEBI:17239", "species_159448", "species_727810", "CHEBI:15918", "CHEBI:17713", "Q6P618", "ENSXETG00000006260", "A0A6I8Q090", "ENSXETG00000033226" ] }, "reaction_10312076": { "compartment": "compartment_70101", "id": "reaction_10312076", "reactome": "R-XTR-75125", "name": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_500006" ], "products": [ "species_500009", "species_113592" ], "modifiers": [ [ "species_10311896", "catalyst" ] ], "additional_components": [ "species_417888", "CHEBI:28846", "CHEBI:17239", "species_727810", "CHEBI:15918", "species_109402", "ENSXETG00000036011" ] }, "reaction_10312366": { "compartment": "compartment_70101", "id": "reaction_10312366", "reactome": "R-XTR-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788778", "species_113592" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10312361", "catalyst" ] ], "additional_components": [ "species_159448", "species_727810", "CHEBI:15918", "CHEBI:17713", "species_29370", "CHEBI:28846", "CHEBI:16174", "CHEBI:17239", "Q6P618", "ENSXETG00000006260", "A0A6I8Q090", "ENSXETG00000033226" ] }, "reaction_10312373": { "compartment": "compartment_70101", "id": "reaction_10312373", "reactome": "R-XTR-110144", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_113592", "species_76577" ], "modifiers": [ [ "species_10312370", "catalyst" ] ], "additional_components": [ "ENSXETT00000057918" ] }, "reaction_10312550": { "compartment": "compartment_70101", "id": "reaction_10312550", "reactome": "R-XTR-111746", "name": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312547", "species_29450" ], "products": [ "species_10312544", "species_111745" ], "modifiers": [ [ "species_10312547", "catalyst" ] ], "additional_components": [ "ENSXETG00000026267", "ENSXETG00000026267", "ENSXETG00000026267" ] }, "reaction_10311926": { "compartment": "compartment_7660", "id": "reaction_10311926", "reactome": "R-XTR-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742" ], "modifiers": [ [ "species_10311923", "catalyst" ] ], "additional_components": [ "A0A6I8RWX6", "ENSXETG00000036738" ] }, "reaction_10326748": { "compartment": "compartment_70101", "id": "reaction_10326748", "reactome": "R-XTR-2395879", "name": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395883", "species_29356" ], "products": [ "species_2395817", "species_29372" ], "modifiers": [ [ "species_10326740", "catalyst" ] ], "additional_components": [ "ENSXETG00000037630" ] }, "reaction_10326751": { "compartment": "compartment_70101", "id": "reaction_10326751", "reactome": "R-XTR-2395965", "name": "NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395963", "species_29356" ], "products": [ "species_29372", "species_2395964" ], "modifiers": [ [ "species_10326740", "catalyst" ] ], "additional_components": [ "ENSXETG00000037630" ] }, "reaction_10326734": { "compartment": "compartment_70101", "id": "reaction_10326734", "reactome": "R-XTR-2395869", "name": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395852" ], "products": [ "species_111294", "species_2395817" ], "modifiers": [ [ "species_10326731", "catalyst" ] ], "additional_components": [ "ENSXETG00000039868" ] }, "reaction_10326746": { "compartment": "compartment_70101", "id": "reaction_10326746", "reactome": "R-XTR-2395876", "name": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395883", "species_29356" ], "products": [ "species_2395817", "species_29372" ], "modifiers": [ [ "species_10326731", "catalyst" ] ], "additional_components": [ "ENSXETG00000039868" ] }, "reaction_10326724": { "compartment": "compartment_70101", "id": "reaction_10326724", "reactome": "R-XTR-2395818", "name": "NUDT1 hydrolyses 2-OH-dATP to 2-OH-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395822" ], "products": [ "species_111294", "species_2395855" ], "modifiers": [ [ "species_10326721", "catalyst" ] ], "additional_components": [ "species_109496", "Q6GL35", "ENSXETT00000085967" ] }, "reaction_10326727": { "compartment": "compartment_70101", "id": "reaction_10326727", "reactome": "R-XTR-2395849", "name": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395852" ], "products": [ "species_111294", "species_2395817" ], "modifiers": [ [ "species_10326721", "catalyst" ] ], "additional_components": [ "species_109496", "Q6GL35", "ENSXETT00000085967" ] }, "reaction_10326743": { "compartment": "compartment_70101", "id": "reaction_10326743", "reactome": "R-XTR-2395873", "name": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395880" ], "products": [ "species_29372", "species_2395877" ], "modifiers": [ [ "species_10326740", "catalyst" ] ], "additional_components": [ "ENSXETG00000037630" ] }, "reaction_10331430": { "compartment": "compartment_70101", "id": "reaction_10331430", "reactome": "R-XTR-5696049", "name": "ADPRM hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1131972" ], "products": [ "species_73578", "species_76577" ], "modifiers": [ [ "species_10331427", "catalyst" ] ], "additional_components": [ "CHEBI:29035", "Q66JJ3", "ENSXETT00000024142" ] }, "reaction_10326736": { "compartment": "compartment_70101", "id": "reaction_10326736", "reactome": "R-XTR-2395872", "name": "NUDT1 hydrolyses 2-OH-ATP to 2-OH-AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395868" ], "products": [ "species_111294", "species_2395878" ], "modifiers": [ [ "species_10326721", "catalyst" ] ], "additional_components": [ "species_109496", "Q6GL35", "ENSXETT00000085967" ] }, "reaction_10312296": { "compartment": "compartment_70101", "id": "reaction_10312296", "reactome": "R-XTR-109387", "name": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500125" ], "products": [ "species_29372", "species_500124" ], "modifiers": [ [ "species_10312291", "catalyst" ], [ "species_29370", "catalyst" ] ], "additional_components": [ "species_159448", "species_29602", "species_109330", "CHEBI:17713", "species_5696194", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_8857850", "CHEBI:17256", "species_83927", "CHEBI:16750", "species_109496", "A0A6I8QEC6", "ENSXETG00000037368" ] }, "reaction_10326856": { "compartment": "compartment_70101", "id": "reaction_10326856", "reactome": "R-XTR-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_111294", "species_109330" ], "modifiers": [ [ "species_10326847", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "A0A6I8SWT3", "ENSXETG00000036089" ] }, "reaction_10312011": { "compartment": "compartment_70101", "id": "reaction_10312011", "reactome": "R-XTR-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500120", "species_29356" ], "products": [ "species_29372", "species_500118" ], "modifiers": [ [ "species_10312008", "catalyst" ] ], "additional_components": [ "species_29602", "species_109330", "species_5696194", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_83927", "CHEBI:16750", "species_109496", "Q5EBF1", "ENSXETG00000009475" ] }, "reaction_10326853": { "compartment": "compartment_70101", "id": "reaction_10326853", "reactome": "R-XTR-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_111294", "species_111584" ], "modifiers": [ [ "species_10326847", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "A0A6I8SWT3", "ENSXETG00000036089" ] }, "reaction_10312305": { "compartment": "compartment_70101", "id": "reaction_10312305", "reactome": "R-XTR-109470", "name": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500120", "species_29356" ], "products": [ "species_29372", "species_500118" ], "modifiers": [ [ "species_10312302", "catalyst" ] ], "additional_components": [ "species_29602", "species_109330", "species_5696194", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_83927", "CHEBI:16750", "A0A6I8QJ17", "ENSXETG00000037325", "species_109496" ] }, "reaction_10326850": { "compartment": "compartment_70101", "id": "reaction_10326850", "reactome": "R-XTR-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_111294", "species_29602" ], "modifiers": [ [ "species_10326847", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "A0A6I8SWT3", "ENSXETG00000036089" ] }, "reaction_10312314": { "compartment": "compartment_5460", "id": "reaction_10312314", "reactome": "R-XTR-109514", "name": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500420", "species_113521" ], "products": [ "species_113548", "species_500421" ], "modifiers": [ [ "species_10312311", "catalyst" ] ], "additional_components": [ "species_109366", "species_500742", "CHEBI:28895", "species_109402", "CHEBI:28070", "species_83928", "CHEBI:16450", "CHEBI:16704", "A0A6I8QJ17", "ENSXETG00000037325", "species_109496" ] }, "reaction_10312294": { "compartment": "compartment_70101", "id": "reaction_10312294", "reactome": "R-XTR-109380", "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500347" ], "products": [ "species_500346", "species_29372" ], "modifiers": [ [ "species_10312291", "catalyst" ], [ "species_29370", "catalyst" ] ], "additional_components": [ "species_727810", "CHEBI:15918", "species_109366", "species_500742", "species_109402", "CHEBI:15698", "CHEBI:16450", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_109496", "A0A6I8QEC6", "ENSXETG00000037368" ] }, "reaction_10312307": { "compartment": "compartment_70101", "id": "reaction_10312307", "reactome": "R-XTR-109480", "name": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500414" ], "products": [ "species_29372", "species_500415" ], "modifiers": [ [ "species_10312302", "catalyst" ] ], "additional_components": [ "CHEBI:28070", "CHEBI:28895", "species_109366", "species_500742", "CHEBI:46322", "species_109402", "CHEBI:16450", "CHEBI:16704", "species_83928", "A0A6I8QJ17", "ENSXETG00000037325", "species_109496" ] }, "reaction_10334973": { "compartment": "compartment_984", "id": "reaction_10334973", "reactome": "R-XTR-8851356", "name": "NTPDase5 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8936165" ], "products": [ "species_8851369", "species_109277" ], "modifiers": [ [ "species_10334970", "catalyst" ] ], "additional_components": [ "species_29370", "species_417888", "species_29420", "CHEBI:17239", "species_109402", "species_727810", "species_5696194", "species_159448", "A0A6I8Q679", "ENSXETG00000030591", "species_109496", "species_74112" ] }, "reaction_10334998": { "compartment": "compartment_528865", "id": "reaction_10334998", "reactome": "R-XTR-8851494", "name": "NTPDase7 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851517", "species_8851509" ], "products": [ "species_8851513", "species_8851518" ], "modifiers": [ [ "species_10334995", "catalyst" ] ], "additional_components": [ "CHEBI:15713", "species_29438", "CHEBI:17677", "CHEBI:17239", "species_417888", "species_29420", "species_74112", "Q28CF8", "ENSXETG00000003746" ] }, "reaction_10334848": { "compartment": "compartment_984", "id": "reaction_10334848", "reactome": "R-XTR-8850846", "name": "NTPDase1 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8870907" ], "products": [ "species_8870906", "species_109277" ], "modifiers": [ [ "species_10334845", "catalyst" ] ], "additional_components": [ "A0A6I8QSY1", "ENSXETG00000037156", "species_109496", "species_74112" ] }, "reaction_10334960": { "compartment": "compartment_984", "id": "reaction_10334960", "reactome": "R-XTR-8851089", "name": "NTPDase2 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936166", "species_109276" ], "products": [ "species_109277", "species_8851092" ], "modifiers": [ [ "species_10334957", "catalyst" ] ], "additional_components": [ "species_2509836", "species_29438", "CHEBI:15713", "CHEBI:17677", "species_113593", "CHEBI:17808", "species_29370", "species_417888", "species_29420", "CHEBI:17239", "K9J7Q8", "ENSXETT00000008576", "species_109496", "species_74112" ] }, "reaction_10334851": { "compartment": "compartment_876", "id": "reaction_10334851", "reactome": "R-XTR-8850854", "name": "NTPDase1 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8870906" ], "products": [ "species_109277", "species_8870962" ], "modifiers": [ [ "species_10334845", "catalyst" ] ], "additional_components": [ "A0A6I8QSY1", "ENSXETG00000037156", "species_109496", "species_74112" ] }, "reaction_10311933": { "compartment": "compartment_70101", "id": "reaction_10311933", "reactome": "R-XTR-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_111584", "species_29472" ], "products": [ "species_111294", "species_29404", "species_113578", "species_76577" ], "modifiers": [ [ "species_10311930", "catalyst" ] ], "additional_components": [ "ENSXETG00000033049" ] }, "reaction_10312540": { "compartment": "compartment_70101", "id": "reaction_10312540", "reactome": "R-XTR-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29448", "species_29602" ], "products": [ "species_29372", "species_29420", "species_35141" ], "modifiers": [ [ "species_10312537", "catalyst" ], [ "species_30014", "inhibitor" ], [ "species_29420", "inhibitor" ], [ "species_35141", "inhibitor" ], [ "species_113578", "inhibitor" ] ], "additional_components": [ "Q6DIW6", "ENSXETG00000024695", "species_109496", "Q6P875", "ENSXETG00000014538" ] }, "reaction_10311946": { "compartment": "compartment_70101", "id": "reaction_10311946", "reactome": "R-XTR-73814", "name": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111292", "species_113592", "species_29424" ], "products": [ "species_29372", "species_111338", "species_29370" ], "modifiers": [ [ "species_10311937", "catalyst" ] ], "additional_components": [ "ENSXETG00000014148" ] }, "reaction_10311940": { "compartment": "compartment_70101", "id": "reaction_10311940", "reactome": "R-XTR-73810", "name": "FGAM + ATP => AIR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111369" ], "products": [ "species_29372", "species_111370", "species_29370" ], "modifiers": [ [ "species_10311937", "catalyst" ] ], "additional_components": [ "ENSXETG00000014148" ] }, "reaction_10311943": { "compartment": "compartment_70101", "id": "reaction_10311943", "reactome": "R-XTR-73813", "name": "GAR + 10-Formyl-THF => FGAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111338", "species_419151" ], "products": [ "species_111354", "species_111355" ], "modifiers": [ [ "species_10311937", "catalyst" ] ], "additional_components": [ "ENSXETG00000014148" ] }, "reaction_10332370": { "compartment": "compartment_70101", "id": "reaction_10332370", "reactome": "R-XTR-6788912", "name": "LHPP:Mg2+ dimer hydrolyses PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10332367", "catalyst" ] ], "additional_components": [ "A0A6I8PWJ2", "ENSXETG00000031230", "species_109496" ] }, "reaction_10315931": { "compartment": "compartment_70101", "id": "reaction_10315931", "reactome": "R-XTR-203553", "name": "eNOS binds NOSIP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315923", "species_10315927" ], "products": [ "species_10315929" ], "modifiers": [], "additional_components": [ "species_189444", "species_29426", "species_73524", "species_113596", "A0A6I8RYH7", "ENSXETG00000011979", "ENSXETT00000065273", "Q6P829", "ENSXETT00000065273", "species_189444", "species_29426", "species_73524", "species_113596", "A0A6I8RYH7", "ENSXETG00000011979" ] }, "reaction_10315952": { "compartment": "compartment_876", "id": "reaction_10315952", "reactome": "R-XTR-203680", "name": "eNOS:NOSIP translocation from caveolae to intracellular compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315929" ], "products": [ "species_10315950" ], "modifiers": [], "additional_components": [ "Q6P829", "ENSXETT00000065273", "species_189444", "species_29426", "species_73524", "species_113596", "A0A6I8RYH7", "ENSXETG00000011979", "Q6P829", "ENSXETT00000065273", "A0A6I8RYH7", "ENSXETG00000011979", "species_189444", "species_29426", "species_73524", "species_113596", "species_29870" ] }, "reaction_10315944": { "compartment": "compartment_70101", "id": "reaction_10315944", "reactome": "R-XTR-203611", "name": "N-myristoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_184174", "species_10315942" ], "products": [ "species_10315712" ], "modifiers": [], "additional_components": [ "ENSXETG00000011979", "ENSXETG00000011979" ] }, "reaction_10315720": { "compartment": "compartment_20699", "id": "reaction_10315720", "reactome": "R-XTR-202132", "name": "depalmitoylated eNOS translocates from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315714" ], "products": [ "species_10315718" ], "modifiers": [], "additional_components": [ "species_189444", "species_29426", "species_73524", "species_113596", "A0A6I8RYH7", "ENSXETG00000011979", "species_29870", "species_189444", "species_29426", "species_73524", "A0A6I8RYH7", "ENSXETG00000011979", "species_113596", "species_29870" ] }, "reaction_10315940": { "compartment": "compartment_20699", "id": "reaction_10315940", "reactome": "R-XTR-203567", "name": "palmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315712", "species_200993" ], "products": [ "species_10315933" ], "modifiers": [ [ "species_10315937", "catalyst" ] ], "additional_components": [ "ENSXETG00000011979", "ENSXETG00000011979", "ENSXETT00000055800" ] }, "reaction_10329588": { "compartment": "compartment_70101", "id": "reaction_10329588", "reactome": "R-XTR-5340226", "name": "CYGB dioxygenates NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_202124", "species_70106", "species_29364", "species_10329583" ], "products": [ "species_432031", "species_29366", "species_10329581" ], "modifiers": [ [ "species_10329583", "catalyst" ] ], "additional_components": [ "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_113533", "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_113533" ] }, "reaction_10329585": { "compartment": "compartment_70101", "id": "reaction_10329585", "reactome": "R-XTR-5340214", "name": "CYGB binds O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_10329581" ], "products": [ "species_10329583" ], "modifiers": [], "additional_components": [ "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_113533" ] }, "reaction_10315954": { "compartment": "compartment_20699", "id": "reaction_10315954", "reactome": "R-XTR-203700", "name": "eNOS translocation from Golgi to Caveolae", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315933" ], "products": [ "species_10315923" ], "modifiers": [], "additional_components": [ "ENSXETG00000011979", "species_189444", "species_29426", "species_73524", "species_113596", "A0A6I8RYH7", "ENSXETG00000011979" ] }, "reaction_10313418": { "compartment": "compartment_70616", "id": "reaction_10313418", "reactome": "R-XTR-170026", "name": "Protons are translocated from the intermembrane space to the matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163953" ], "products": [ "species_113529" ], "modifiers": [ [ "species_10313240", "catalyst" ], [ "species_30495", "catalyst" ], [ "species_170037", "inhibitor" ] ], "additional_components": [ "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_113593", "species_29370", "species_29420", "species_29438" ] }, "reaction_10313247": { "compartment": "compartment_70616", "id": "reaction_10313247", "reactome": "R-XTR-166214", "name": "FA anion flip-flops to the opposite surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313242" ], "products": [ "species_10313244" ], "modifiers": [ [ "species_10313242", "catalyst" ] ], "additional_components": [ "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_166216", "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_166216", "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_166216" ] }, "reaction_10313249": { "compartment": "compartment_70616", "id": "reaction_10313249", "reactome": "R-XTR-166220", "name": "FA anion diffuses laterally to UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_166213", "species_10313240" ], "products": [ "species_10313242" ], "modifiers": [], "additional_components": [ "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_166216" ] }, "reaction_10313251": { "compartment": "compartment_70616", "id": "reaction_10313251", "reactome": "R-XTR-166387", "name": "The FA anion diffuses away laterally from UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313244" ], "products": [ "species_166216", "species_10313240" ], "modifiers": [], "additional_components": [ "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_166216", "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740" ] }, "reaction_10338068": { "compartment": "compartment_984", "id": "reaction_10338068", "reactome": "R-XTR-9673054", "name": "PM20D1 hydrolyzes oleoyl-phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_9673044" ], "products": [ "species_351993", "species_9673048" ], "modifiers": [ [ "species_10338063", "catalyst" ] ], "additional_components": [ "ENSXETG00000005950" ] }, "reaction_10338066": { "compartment": "compartment_984", "id": "reaction_10338066", "reactome": "R-XTR-9673053", "name": "PM20D1 transforms oleoyl-phe from oleate and phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351993", "species_9673048" ], "products": [ "species_109276", "species_9673044" ], "modifiers": [ [ "species_10338063", "catalyst" ] ], "additional_components": [ "ENSXETG00000005950" ] }, "reaction_10320175": { "compartment": "compartment_5460", "id": "reaction_10320175", "reactome": "R-XTR-880002", "name": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_880046", "species_879997" ], "products": [ "species_113594", "species_880041" ], "modifiers": [ [ "species_10320172", "catalyst" ] ], "additional_components": [ "ENSXETG00000023251" ] }, "reaction_10332223": { "compartment": "compartment_70101", "id": "reaction_10332223", "reactome": "R-XTR-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29708", "species_29450" ], "modifiers": [ [ "species_10332220", "catalyst" ] ], "additional_components": [ "species_29426", "B4F6K2", "ENSXETG00000007202" ] }, "reaction_10337199": { "compartment": "compartment_5460", "id": "reaction_10337199", "reactome": "R-XTR-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_113557", "species_29376" ], "modifiers": [ [ "species_10337196", "catalyst" ] ], "additional_components": [ "A0A6I8PLR1", "ENSXETG00000033843", "species_109496" ] }, "reaction_10318622": { "compartment": "compartment_5460", "id": "reaction_10318622", "reactome": "R-XTR-450984", "name": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_29938" ], "products": [ "species_113594", "species_113529", "species_113600", "species_29376" ], "modifiers": [ [ "species_10318619", "catalyst" ] ], "additional_components": [ "F6WI63", "ENSXETT00000017597", "CHEBI:29035" ] }, "reaction_10311626": { "compartment": "compartment_5460", "id": "reaction_10311626", "reactome": "R-XTR-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113587", "species_113521" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10311623", "catalyst" ] ], "additional_components": [ "Q28DK1", "ENSXETT00000020990" ] }, "reaction_10311649": { "compartment": "compartment_5460", "id": "reaction_10311649", "reactome": "R-XTR-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10311646", "catalyst" ] ], "additional_components": [ "Q6P355", "ENSXETT00000057629", "B0BM36", "ENSXETG00000013435", "Q28ED0", "ENSXETT00000087904", "species_113596" ] }, "reaction_10311869": { "compartment": "compartment_70101", "id": "reaction_10311869", "reactome": "R-XTR-71732", "name": "pyrophosphate + H2O => 2 orthophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10311866", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "A0A6I8S9S0", "ENSXETG00000014102" ] }, "reaction_10318570": { "compartment": "compartment_5460", "id": "reaction_10318570", "reactome": "R-XTR-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159450", "species_113521" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10318567", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "A0A6I8S9S0", "ENSXETG00000014102" ] }, "reaction_10330207": { "compartment": "compartment_70101", "id": "reaction_10330207", "reactome": "R-XTR-5652195", "name": "SORD oxidizes D-sorbitol to Fru", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5652213", "species_29360" ], "products": [ "species_29532", "species_70106", "species_73473" ], "modifiers": [ [ "species_10330204", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8PMG1", "ENSXETG00000023897" ] }, "reaction_10337689": { "compartment": "compartment_161320", "id": "reaction_10337689", "reactome": "R-XTR-9036727", "name": "GAA hydrolyzes lysosomal glycogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_10337678" ], "products": [ "species_10337682", "species_1605745" ], "modifiers": [ [ "species_10337684", "catalyst" ] ], "additional_components": [ "A0A6I8SJ17", "ENSXETG00000016072", "CHEBI:29035", "CHEBI:29035", "A0A6I8SJ17", "ENSXETG00000016072", "ENSXETT00000002749" ] }, "reaction_10337919": { "compartment": "compartment_70101", "id": "reaction_10337919", "reactome": "R-XTR-9638125", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10337916", "catalyst" ] ], "additional_components": [ "species_109496", "F6PKQ4", "ENSXETT00000023697" ] }, "reaction_10311436": { "compartment": "compartment_70101", "id": "reaction_10311436", "reactome": "R-XTR-70467", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_30014", "species_29370" ], "modifiers": [ [ "species_10311433", "catalyst" ], [ "species_30533", "catalyst" ], [ "species_29370", "catalyst" ], [ "species_76577", "catalyst" ], [ "species_76190", "inhibitor" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "A0A6I8RGQ8", "ENSXETG00000007279" ] }, "reaction_10333611": { "compartment": "compartment_70101", "id": "reaction_10333611", "reactome": "R-XTR-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_449701" ], "products": [ "species_29512", "species_31633" ], "modifiers": [ [ "species_10333608", "catalyst" ] ], "additional_components": [ "A4IHW6", "ENSXETT00000018476" ] }, "reaction_10311418": { "compartment": "compartment_70101", "id": "reaction_10311418", "reactome": "R-XTR-70420", "name": "HK1,2,3,GCK phosphorylate Glc to form G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_70113" ], "products": [ "species_70106", "species_29370", "species_30537" ], "modifiers": [ [ "species_10311413", "catalyst" ] ], "additional_components": [ "ENSXETT00000005874" ] }, "reaction_10311878": { "compartment": "compartment_70101", "id": "reaction_10311878", "reactome": "R-XTR-71850", "name": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_29800" ], "products": [ "species_113592", "species_29728" ], "modifiers": [ [ "species_10311459", "catalyst" ] ], "additional_components": [ "A0A6I8SHY7", "ENSXETG00000007447", "species_109496" ] }, "reaction_10311427": { "compartment": "compartment_70101", "id": "reaction_10311427", "reactome": "R-XTR-70454", "name": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75970" ], "products": [ "species_29578" ], "modifiers": [ [ "species_10311424", "catalyst" ] ], "additional_components": [ "B0BM40", "ENSXETG00000023924" ] }, "reaction_10327532": { "compartment": "compartment_17957", "id": "reaction_10327532", "reactome": "R-XTR-3262512", "name": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_113782" ], "products": [ "species_113551", "species_113780" ], "modifiers": [ [ "species_10327529", "catalyst" ] ], "additional_components": [ "ENSXETG00000032824" ] }, "reaction_10311471": { "compartment": "compartment_5460", "id": "reaction_10311471", "reactome": "R-XTR-70501", "name": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113557", "species_29376" ], "products": [ "species_113548", "species_113581", "species_113587" ], "modifiers": [ [ "species_10311468", "catalyst" ], [ "species_113559", "catalyst" ] ], "additional_components": [ "CHEBI:29035", "A0A6I8QW74", "ENSXETG00000008415", "species_199207" ] }, "reaction_10314378": { "compartment": "compartment_70101", "id": "reaction_10314378", "reactome": "R-XTR-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_29360" ], "products": [ "species_70106", "species_76213", "species_73473" ], "modifiers": [ [ "species_10314375", "catalyst" ] ], "additional_components": [ "Q6DIY9", "ENSXETT00000101573" ] }, "reaction_10311445": { "compartment": "compartment_70101", "id": "reaction_10311445", "reactome": "R-XTR-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10311442", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "species_109496", "Q6P8F7", "ENSXETT00000049063" ] }, "reaction_10327525": { "compartment": "compartment_70101", "id": "reaction_10327525", "reactome": "R-XTR-3257122", "name": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113551", "species_30537" ], "products": [ "species_29372", "species_113782" ], "modifiers": [ [ "species_10327522", "catalyst" ] ], "additional_components": [ "ENSXETT00000094617" ] }, "reaction_10311876": { "compartment": "compartment_17957", "id": "reaction_10311876", "reactome": "R-XTR-71825", "name": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_113782" ], "products": [ "species_113551", "species_113780" ], "modifiers": [ [ "species_10311873", "catalyst" ] ], "additional_components": [ "ENSXETT00000033981" ] }, "reaction_10325949": { "compartment": "compartment_20699", "id": "reaction_10325949", "reactome": "R-XTR-2076419", "name": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10325677" ], "products": [ "species_742343", "species_10325691" ], "modifiers": [ [ "species_10325946", "catalyst" ] ], "additional_components": [ "Q0V9W0", "ENSXETT00000104077", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "ENSXETT00000011900" ] }, "reaction_10325593": { "compartment": "compartment_20699", "id": "reaction_10325593", "reactome": "R-XTR-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325590", "species_2022884" ], "products": [ "species_10325545", "species_2022890" ], "modifiers": [ [ "species_10325568", "catalyst" ] ], "additional_components": [ "A0A6I8R4L4", "ENSXETG00000039039", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8PYW4", "ENSXETG00000007104", "Q0V9W0", "ENSXETT00000104077", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "ENSXETG00000015804" ] }, "reaction_10319098": { "compartment": "compartment_20699", "id": "reaction_10319098", "reactome": "R-XTR-744231", "name": "SLC35D2 exchanges UDP-sugars for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744229", "species_735698" ], "products": [ "species_109402", "species_744234" ], "modifiers": [ [ "species_10319093", "catalyst" ] ], "additional_components": [ "species_744227", "species_162756", "species_744227", "species_162756", "ENSXETG00000041312" ] }, "reaction_10325767": { "compartment": "compartment_17963", "id": "reaction_10325767", "reactome": "R-XTR-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325693" ], "products": [ "species_10325765" ], "modifiers": [], "additional_components": [ "Q0V9W0", "ENSXETT00000104077", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8SBK0", "ENSXETG00000032333" ] }, "reaction_10325571": { "compartment": "compartment_20699", "id": "reaction_10325571", "reactome": "R-XTR-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10325545" ], "products": [ "species_742343", "species_10325564" ], "modifiers": [ [ "species_10325568", "catalyst" ] ], "additional_components": [ "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "Q0V9W0", "ENSXETT00000104077", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8R4L4", "ENSXETG00000039039", "ENSXETG00000015804" ] }, "reaction_10324079": { "compartment": "compartment_17938", "id": "reaction_10324079", "reactome": "R-XTR-1678660", "name": "HGSNAT oligomer acetylates Heparan sulfate chain(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090040", "species_76183" ], "products": [ "species_2090069", "species_76194" ], "modifiers": [ [ "species_10324076", "catalyst" ] ], "additional_components": [ "A0A6I8PYT1", "ENSXETG00000036665" ] }, "reaction_10325961": { "compartment": "compartment_161320", "id": "reaction_10325961", "reactome": "R-XTR-2090037", "name": "IDUA hydrolyses Heparan sulfate chain(6)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090055" ], "products": [ "species_2090070", "species_1678617" ], "modifiers": [ [ "species_10324111", "catalyst" ] ], "additional_components": [ "ENSXETG00000031913" ] }, "reaction_10325963": { "compartment": "compartment_17938", "id": "reaction_10325963", "reactome": "R-XTR-2090085", "name": "HGSNAT oligomer acetylates Heparan chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_2090045" ], "products": [ "species_2090053", "species_76194" ], "modifiers": [ [ "species_10324076", "catalyst" ] ], "additional_components": [ "A0A6I8PYT1", "ENSXETG00000036665" ] }, "reaction_10325601": { "compartment": "compartment_876", "id": "reaction_10325601", "reactome": "R-XTR-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324093" ], "products": [ "species_10323951" ], "modifiers": [], "additional_components": [ "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R5Q9", "ENSXETG00000035467", "Q0V9W0", "ENSXETT00000104077", "A0A6I8R4L4", "ENSXETG00000039039" ] }, "reaction_10324114": { "compartment": "compartment_161320", "id": "reaction_10324114", "reactome": "R-XTR-1678716", "name": "IDUA hydrolyses Heparan sulfate chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090033", "species_1605715" ], "products": [ "species_2090072", "species_1678617" ], "modifiers": [ [ "species_10324111", "catalyst" ] ], "additional_components": [ "ENSXETG00000031913" ] }, "reaction_10337912": { "compartment": "compartment_20699", "id": "reaction_10337912", "reactome": "R-XTR-9638064", "name": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10324414" ], "products": [ "species_10324442", "species_205687" ], "modifiers": [ [ "species_10324448", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8PV84", "ENSXETG00000015273", "F7DRX3", "ENSXETT00000049772", "CHEBI:29035" ] }, "reaction_10324451": { "compartment": "compartment_20699", "id": "reaction_10324451", "reactome": "R-XTR-1889955", "name": "B3GAT dimers transfer GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10324414" ], "products": [ "species_10324442", "species_205687" ], "modifiers": [ [ "species_10324448", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8PV84", "ENSXETG00000015273", "F7DRX3", "ENSXETT00000049772", "CHEBI:29035" ] }, "reaction_10324386": { "compartment": "compartment_20699", "id": "reaction_10324386", "reactome": "R-XTR-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324351", "species_742361" ], "products": [ "species_10324379", "species_205687" ], "modifiers": [ [ "species_10324383", "catalyst" ] ], "additional_components": [ "Q0V9W0", "ENSXETT00000104077", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R4L4", "ENSXETG00000039039", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8R4L4", "ENSXETG00000039039", "A0A6I8SBK0", "ENSXETG00000032333", "A4IIC2", "ENSXETT00000063928", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8PV84", "ENSXETG00000015273", "Q0V9W0", "ENSXETT00000104077", "ENSXETG00000006839" ] }, "reaction_10325917": { "compartment": "compartment_984", "id": "reaction_10325917", "reactome": "R-XTR-2046239", "name": "Extracellular KSPG translocates to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325889" ], "products": [ "species_10324223" ], "modifiers": [], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260" ] }, "reaction_10325932": { "compartment": "compartment_20699", "id": "reaction_10325932", "reactome": "R-XTR-2046285", "name": "The keratan chain can be capped by N-acetylneuraminic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_10325925" ], "products": [ "species_10325894", "species_727810" ], "modifiers": [ [ "species_10325929", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "ENSXETG00000026104" ] }, "reaction_10325774": { "compartment": "compartment_20699", "id": "reaction_10325774", "reactome": "R-XTR-2025723", "name": "B4GALTs transfer Gal to the N-glycan precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10325769" ], "products": [ "species_205687", "species_10325772" ], "modifiers": [ [ "species_10320782", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "A0A6I8QS90", "ENSXETG00000034513" ] }, "reaction_10325934": { "compartment": "compartment_20699", "id": "reaction_10325934", "reactome": "R-XTR-2046298", "name": "B4GALTs transfer Gal to a branch of keratan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325920", "species_735682" ], "products": [ "species_10325925", "species_205687" ], "modifiers": [ [ "species_10320782", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "A0A6I8QS90", "ENSXETG00000034513" ] }, "reaction_10325915": { "compartment": "compartment_20699", "id": "reaction_10325915", "reactome": "R-XTR-2046222", "name": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10325894" ], "products": [ "species_742343", "species_10325885" ], "modifiers": [ [ "species_10325912", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "A0A6I8Q6E3", "ENSXETG00000040380", "A0A6I8PUA8", "ENSXETG00000034141" ] }, "reaction_10325780": { "compartment": "compartment_20699", "id": "reaction_10325780", "reactome": "R-XTR-2025724", "name": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10325772" ], "products": [ "species_10325777", "species_205687" ], "modifiers": [ [ "species_10320403", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "ENSXETG00000040687" ] }, "reaction_10325891": { "compartment": "compartment_17963", "id": "reaction_10325891", "reactome": "R-XTR-2046180", "name": "KSPG is secreted from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325887" ], "products": [ "species_10325889" ], "modifiers": [], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260" ] }, "reaction_10325922": { "compartment": "compartment_20699", "id": "reaction_10325922", "reactome": "R-XTR-2046265", "name": "B4GALTs transfer Gal to the keratan chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325777", "species_735682" ], "products": [ "species_10325920", "species_205687" ], "modifiers": [ [ "species_10320782", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "A0A6I8QS90", "ENSXETG00000034513" ] }, "reaction_10326060": { "compartment": "compartment_161320", "id": "reaction_10326060", "reactome": "R-XTR-2160874", "name": "HYAL1 hydrolyses (HA)50", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2160864" ], "products": [ "species_2160866" ], "modifiers": [ [ "species_10324215", "catalyst" ] ], "additional_components": [ "species_2142867", "species_2142867", "ENSXETG00000040650" ] }, "reaction_10326088": { "compartment": "compartment_876", "id": "reaction_10326088", "reactome": "R-XTR-2160915", "name": "Receptor-mediated uptake of HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326064", "species_10326068", "species_2160848" ], "products": [ "species_10326070" ], "modifiers": [], "additional_components": [ "ENSXETG00000035220", "ENSXETT00000004761", "species_2142867", "species_2142867", "F7EIX5", "ENSXETT00000004761", "A0A6I8QK29", "ENSXETG00000035220" ] }, "reaction_10326086": { "compartment": "compartment_876", "id": "reaction_10326086", "reactome": "R-XTR-2160892", "name": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326083" ], "products": [ "species_2160894", "species_10326083" ], "modifiers": [ [ "species_10326083", "catalyst" ] ], "additional_components": [ "species_2142867", "F7EIX5", "ENSXETT00000004761", "A0A6I8QK29", "ENSXETG00000035220", "Q6DK70", "ENSXETT00000057366", "species_74112", "species_2142867", "species_2142867", "F7EIX5", "ENSXETT00000004761", "A0A6I8QK29", "ENSXETG00000035220", "Q6DK70", "ENSXETT00000057366", "species_74112", "species_2142867", "F7EIX5", "ENSXETT00000004761", "A0A6I8QK29", "ENSXETG00000035220", "Q6DK70", "ENSXETT00000057366", "species_74112" ] }, "reaction_10331295": { "compartment": "compartment_984", "id": "reaction_10331295", "reactome": "R-XTR-5693356", "name": "CEMIP hydrolyses HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2160848" ], "products": [ "species_5693343", "species_2160848" ], "modifiers": [ [ "species_10331292", "catalyst" ] ], "additional_components": [ "species_2142867", "species_2142867", "ENSXETG00000012981" ] }, "reaction_10326058": { "compartment": "compartment_876", "id": "reaction_10326058", "reactome": "R-XTR-2160851", "name": "HAS1,2,3 mediate the polymerisation of HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142867" ], "products": [ "species_2142896" ], "modifiers": [ [ "species_10326055", "catalyst" ] ], "additional_components": [ "species_2142867", "ENSXETG00000004083" ] }, "reaction_10325597": { "compartment": "compartment_17963", "id": "reaction_10325597", "reactome": "R-XTR-2022911", "name": "CSPG is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325595" ], "products": [ "species_10324884" ], "modifiers": [], "additional_components": [ "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928" ] }, "reaction_10324604": { "compartment": "compartment_20699", "id": "reaction_10324604", "reactome": "R-XTR-1971491", "name": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10324544" ], "products": [ "species_10324594", "species_205687" ], "modifiers": [ [ "species_10324598", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "ENSXETG00000030580" ] }, "reaction_10324796": { "compartment": "compartment_20699", "id": "reaction_10324796", "reactome": "R-XTR-2018682", "name": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10324555" ], "products": [ "species_742343", "species_10324789" ], "modifiers": [ [ "species_10324793", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "ENSXETG00000032713" ] }, "reaction_10324601": { "compartment": "compartment_20699", "id": "reaction_10324601", "reactome": "R-XTR-1971487", "name": "CHPF,CHSY3 transfer GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10324594" ], "products": [ "species_10324555", "species_205687" ], "modifiers": [ [ "species_10324598", "catalyst" ] ], "additional_components": [ "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "ENSXETG00000030580" ] }, "reaction_10324778": { "compartment": "compartment_20699", "id": "reaction_10324778", "reactome": "R-XTR-2018659", "name": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10324566" ], "products": [ "species_10324771", "species_742343" ], "modifiers": [ [ "species_10324775", "catalyst" ] ], "additional_components": [ "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "ENSXETT00000038652" ] }, "reaction_10337892": { "compartment": "compartment_20699", "id": "reaction_10337892", "reactome": "R-XTR-9632034", "name": "CHSY1 transfers GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10324544" ], "products": [ "species_10324594", "species_205687" ], "modifiers": [ [ "species_10337886", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "ENSXETG00000018744" ] }, "reaction_10324583": { "compartment": "compartment_20699", "id": "reaction_10324583", "reactome": "R-XTR-1971483", "name": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10324555" ], "products": [ "species_742343", "species_10324566" ], "modifiers": [ [ "species_10324580", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "Q28E26", "ENSXETT00000079954", "A0A6I8Q0S9", "ENSXETG00000001882", "A0A6I8PMV5", "ENSXETG00000027548" ] }, "reaction_10337889": { "compartment": "compartment_20699", "id": "reaction_10337889", "reactome": "R-XTR-9632033", "name": "CHSY1 transfers GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10324594" ], "products": [ "species_10324555", "species_205687" ], "modifiers": [ [ "species_10337886", "catalyst" ] ], "additional_components": [ "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "ENSXETG00000018744" ] }, "reaction_10324829": { "compartment": "compartment_20699", "id": "reaction_10324829", "reactome": "R-XTR-2022052", "name": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324798" ], "products": [ "species_10324822" ], "modifiers": [ [ "species_10324826", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "ENSXETT00000066016" ] }, "reaction_10324954": { "compartment": "compartment_17963", "id": "reaction_10324954", "reactome": "R-XTR-2022065", "name": "DSPGs are secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324952" ], "products": [ "species_10324858" ], "modifiers": [], "additional_components": [ "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928" ] }, "reaction_10324218": { "compartment": "compartment_161320", "id": "reaction_10324218", "reactome": "R-XTR-1793209", "name": "HYAL1 hydrolyses Chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065257" ], "products": [ "species_2065212" ], "modifiers": [ [ "species_10324215", "catalyst" ] ], "additional_components": [ "CHEBI:63512", "CHEBI:63513", "CHEBI:63515", "CHEBI:63511", "ENSXETG00000040650" ] }, "reaction_10324211": { "compartment": "compartment_161320", "id": "reaction_10324211", "reactome": "R-XTR-1793186", "name": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105025" ], "products": [ "species_2104993", "species_1678617" ], "modifiers": [ [ "species_10324111", "catalyst" ] ], "additional_components": [ "ENSXETG00000031913" ] }, "reaction_10324930": { "compartment": "compartment_984", "id": "reaction_10324930", "reactome": "R-XTR-2022056", "name": "DSPG and CSPG translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324884", "species_10324858" ], "products": [ "species_10324928", "species_10324910" ], "modifiers": [], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273" ] }, "reaction_10330365": { "compartment": "compartment_70101", "id": "reaction_10330365", "reactome": "R-XTR-5662471", "name": "SORD tetramer oxidizes xylitol to D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5660033", "species_29360" ], "products": [ "species_70106", "species_5661281", "species_73473" ], "modifiers": [ [ "species_10330204", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8PMG1", "ENSXETG00000023897" ] }, "reaction_10330362": { "compartment": "compartment_70101", "id": "reaction_10330362", "reactome": "R-XTR-5661256", "name": "AKR1A1 reduces D-glucuronate to L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_5661264", "species_29364" ], "products": [ "species_29366", "species_5661268" ], "modifiers": [ [ "species_10330359", "catalyst" ] ], "additional_components": [ "ENSXETT00000007570" ] }, "reaction_10311741": { "compartment": "compartment_70101", "id": "reaction_10311741", "reactome": "R-XTR-71334", "name": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29882" ], "products": [ "species_29512", "species_29878" ], "modifiers": [ [ "species_10311738", "catalyst" ] ], "additional_components": [ "A0A6I8SUP4", "ENSXETG00000025887" ] }, "reaction_10311732": { "compartment": "compartment_70101", "id": "reaction_10311732", "reactome": "R-XTR-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31467" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10311729", "catalyst" ] ], "additional_components": [ "ENSXETG00000038389" ] }, "reaction_10335154": { "compartment": "compartment_161320", "id": "reaction_10335154", "reactome": "R-XTR-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_1678743", "species_6799594" ], "modifiers": [ [ "species_10335151", "catalyst" ] ], "additional_components": [ "ENSXETG00000002247" ] }, "reaction_10337628": { "compartment": "compartment_70101", "id": "reaction_10337628", "reactome": "R-XTR-9033959", "name": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_9033793" ], "products": [ "species_205687", "species_9033802" ], "modifiers": [ [ "species_10337625", "catalyst" ] ], "additional_components": [ "A0A6I8SLE8", "ENSXETG00000038208", "CHEBI:29035" ] }, "reaction_10337694": { "compartment": "compartment_17963", "id": "reaction_10337694", "reactome": "R-XTR-9036987", "name": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9037036" ], "modifiers": [ [ "species_10337691", "catalyst" ] ], "additional_components": [ "ENSXETG00000041078" ] }, "reaction_10337646": { "compartment": "compartment_984", "id": "reaction_10337646", "reactome": "R-XTR-9034042", "name": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9034101", "species_9034046" ], "products": [ "species_417888", "species_9037066" ], "modifiers": [ [ "species_10337643", "catalyst" ] ], "additional_components": [ "A0A6I8SLE8", "ENSXETG00000038208", "CHEBI:29035" ] }, "reaction_10337653": { "compartment": "compartment_984", "id": "reaction_10337653", "reactome": "R-XTR-9034053", "name": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9034101", "species_9034065" ], "products": [ "species_417888", "species_9037067" ], "modifiers": [ [ "species_10337650", "catalyst" ] ], "additional_components": [ "CHEBI:29035", "A0A6I8SLE8", "ENSXETG00000038208" ] }, "reaction_10337639": { "compartment": "compartment_70101", "id": "reaction_10337639", "reactome": "R-XTR-9033961", "name": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_9033793" ], "products": [ "species_9033798", "species_205687" ], "modifiers": [ [ "species_10337636", "catalyst" ] ], "additional_components": [ "CHEBI:29035", "A0A6I8SLE8", "ENSXETG00000038208" ] }, "reaction_10337619": { "compartment": "compartment_17963", "id": "reaction_10337619", "reactome": "R-XTR-9033949", "name": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_205689", "species_9033793" ], "modifiers": [ [ "species_10337616", "catalyst" ] ], "additional_components": [ "ENSXETG00000041078" ] }, "reaction_10337740": { "compartment": "compartment_17963", "id": "reaction_10337740", "reactome": "R-XTR-9605600", "name": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_9033790" ], "products": [ "species_727810", "species_9605685" ], "modifiers": [ [ "species_10325929", "catalyst" ] ], "additional_components": [ "ENSXETG00000026104" ] }, "reaction_10337743": { "compartment": "compartment_17963", "id": "reaction_10337743", "reactome": "R-XTR-9605609", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605595", "species_205683" ], "products": [ "species_9605615", "species_205689" ], "modifiers": [ [ "species_10331319", "catalyst" ] ], "additional_components": [ "ENSXETG00000032714" ] }, "reaction_10337721": { "compartment": "compartment_17963", "id": "reaction_10337721", "reactome": "R-XTR-9603984", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9605593", "species_205689" ], "modifiers": [ [ "species_10337718", "catalyst" ] ], "additional_components": [ "A0A6I8PN52", "ENSXETG00000037458", "A0A6I8PQF9", "ENSXETG00000032714" ] }, "reaction_10337736": { "compartment": "compartment_17963", "id": "reaction_10337736", "reactome": "R-XTR-9603989", "name": "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9604808", "species_735682" ], "products": [ "species_205687", "species_9036984" ], "modifiers": [ [ "species_10337733", "catalyst" ] ], "additional_components": [ "A0A6I8PS91", "ENSXETG00000040256", "A0A6I8PVV6", "ENSXETG00000040256" ] }, "reaction_10337723": { "compartment": "compartment_17963", "id": "reaction_10337723", "reactome": "R-XTR-9603986", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9605607" ], "modifiers": [ [ "species_10331319", "catalyst" ] ], "additional_components": [ "ENSXETG00000032714" ] }, "reaction_10337749": { "compartment": "compartment_17963", "id": "reaction_10337749", "reactome": "R-XTR-9605682", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605685", "species_205683" ], "products": [ "species_9605661", "species_205689" ], "modifiers": [ [ "species_10331319", "catalyst" ] ], "additional_components": [ "ENSXETG00000032714" ] }, "reaction_10337700": { "compartment": "compartment_17963", "id": "reaction_10337700", "reactome": "R-XTR-9603983", "name": "FUT2 transfers Fuc to LeX to form LeY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605593", "species_205683" ], "products": [ "species_205689", "species_9605586" ], "modifiers": [ [ "species_10337691", "catalyst" ] ], "additional_components": [ "ENSXETG00000041078" ] }, "reaction_10337751": { "compartment": "compartment_17963", "id": "reaction_10337751", "reactome": "R-XTR-9605700", "name": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_9605685" ], "products": [ "species_205687", "species_9605718" ], "modifiers": [ [ "species_10335255", "catalyst" ] ], "additional_components": [ "ENSXETG00000033376" ] }, "reaction_10337745": { "compartment": "compartment_17963", "id": "reaction_10337745", "reactome": "R-XTR-9605644", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605649", "species_205683" ], "products": [ "species_205689", "species_9605651" ], "modifiers": [ [ "species_10331319", "catalyst" ] ], "additional_components": [ "ENSXETG00000032714" ] }, "reaction_10337698": { "compartment": "compartment_17963", "id": "reaction_10337698", "reactome": "R-XTR-9603982", "name": "FUT2 transfers Fuc to LeA to form LeB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605607", "species_205683" ], "products": [ "species_205689", "species_9605394" ], "modifiers": [ [ "species_10337691", "catalyst" ] ], "additional_components": [ "ENSXETG00000041078" ] }, "reaction_10322454": { "compartment": "compartment_5460", "id": "reaction_10322454", "reactome": "R-XTR-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113531", "species_10322452" ], "products": [ "species_10322436" ], "modifiers": [], "additional_components": [ "A0A6I8R145", "ENSXETG00000039175", "A0A6I8Q5L5", "ENSXETG00000038488", "Q6P633", "ENSXETT00000057208", "A0A6I8Q5L5", "ENSXETG00000038488", "Q6P633", "ENSXETT00000057208", "A0A6I8R145", "ENSXETG00000039175", "species_435347" ] }, "reaction_10322449": { "compartment": "compartment_5460", "id": "reaction_10322449", "reactome": "R-XTR-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379721", "species_10322436", "species_10322442" ], "products": [ "species_379697", "species_10322446", "species_10322444" ], "modifiers": [ [ "species_10322436", "catalyst" ], [ "species_10322442", "catalyst" ] ], "additional_components": [ "A0A6I8Q5L5", "ENSXETG00000038488", "Q6P633", "ENSXETT00000057208", "A0A6I8R145", "ENSXETG00000039175", "species_435347", "CHEBI:33738", "F7CAB2", "ENSXETT00000030454", "F7CAB2", "ENSXETT00000030454", "CHEBI:33737", "A0A6I8R145", "ENSXETG00000039175", "A0A6I8Q5L5", "ENSXETG00000038488", "Q6P633", "ENSXETT00000057208", "CHEBI:33739", "A0A6I8Q5L5", "ENSXETG00000038488", "Q6P633", "ENSXETT00000057208", "A0A6I8R145", "ENSXETG00000039175", "species_435347", "CHEBI:33738", "F7CAB2", "ENSXETT00000030454" ] }, "reaction_10336048": { "compartment": "compartment_5460", "id": "reaction_10336048", "reactome": "R-XTR-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336040", "species_10336030" ], "products": [ "species_10336042", "species_10336028" ], "modifiers": [ [ "species_10336046", "catalyst" ] ], "additional_components": [ "A0A6I8PNK1", "ENSXETG00000031871", "A0A6I8PY88", "ENSXETG00000030839", "Q6DJ11", "ENSXETT00000054920", "CHEBI:33739", "A0A6I8PNK1", "ENSXETG00000031871", "A0A6I8PY88", "ENSXETG00000030839", "CHEBI:49883", "ENSXETT00000054920", "ENSXETG00000026948" ] }, "reaction_10317263": { "compartment": "compartment_876", "id": "reaction_10317263", "reactome": "R-XTR-381713", "name": "Potassium voltage-gated channels close in reponse to PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317261" ], "products": [ "species_10317261" ], "modifiers": [], "additional_components": [ "A0A6I8PNT1", "ENSXETG00000032745", "A0A6I8PSS9", "ENSXETG00000015573", "A0A6I8PNT1", "ENSXETG00000032745", "A0A6I8PSS9", "ENSXETG00000015573" ] }, "reaction_10317251": { "compartment": "compartment_12045", "id": "reaction_10317251", "reactome": "R-XTR-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317243" ], "products": [ "species_10317249" ], "modifiers": [], "additional_components": [ "F6XEN8", "ENSXETT00000003958", "A0A6I8QV43", "ENSXETG00000005153", "species_114520", "A0A6I8QV43", "ENSXETG00000005153", "F6XEN8", "ENSXETT00000003958" ] }, "reaction_10317267": { "compartment": "compartment_70101", "id": "reaction_10317267", "reactome": "R-XTR-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10317265" ], "products": [ "species_29420", "species_10316760" ], "modifiers": [], "additional_components": [ "species_29420", "Q640R7", "ENSXETT00000104159", "Q640R7", "ENSXETT00000104159", "species_29438" ] }, "reaction_10335625": { "compartment": "compartment_70101", "id": "reaction_10335625", "reactome": "R-XTR-8862380", "name": "HSD17B13 binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331297", "species_8866926" ], "products": [ "species_10335623" ], "modifiers": [], "additional_components": [ "ENSXETT00000002941", "species_171126", "species_163579", "species_171142", "species_171126", "species_163579", "species_171142", "A8WGW3", "ENSXETT00000002941" ] }, "reaction_10335344": { "compartment": "compartment_12045", "id": "reaction_10335344", "reactome": "R-XTR-8857686", "name": "FITM1, FITM2 bind TAGs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549167", "species_10335340" ], "products": [ "species_10335342" ], "modifiers": [], "additional_components": [ "ENSXETG00000001773", "A0JP80", "ENSXETG00000001773", "species_171126" ] }, "reaction_10331439": { "compartment": "compartment_12045", "id": "reaction_10331439", "reactome": "R-XTR-5696119", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_5696122", "species_29368" ], "products": [ "species_29356", "species_1497857", "species_76116", "species_5696116" ], "modifiers": [ [ "species_10331436", "catalyst" ] ], "additional_components": [ "ENSXETG00000005052" ] }, "reaction_10333674": { "compartment": "compartment_12045", "id": "reaction_10333674", "reactome": "R-XTR-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76103", "species_76194" ], "modifiers": [ [ "species_10333671", "catalyst" ] ], "additional_components": [ "Q5M8H5", "ENSXETT00000008697", "Q28C88", "ENSXETG00000002935" ] }, "reaction_10319045": { "compartment": "compartment_70101", "id": "reaction_10319045", "reactome": "R-XTR-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10319042", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10323897": { "compartment": "compartment_876", "id": "reaction_10323897", "reactome": "R-XTR-1606583", "name": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429807" ], "products": [ "species_1606609", "species_1861754" ], "modifiers": [ [ "species_10323894", "catalyst" ] ], "additional_components": [] }, "reaction_10323915": { "compartment": "compartment_20699", "id": "reaction_10323915", "reactome": "R-XTR-1638104", "name": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744227", "species_428270" ], "products": [ "species_1660674", "species_205687" ], "modifiers": [ [ "species_10323912", "catalyst" ] ], "additional_components": [ "ENSXETT00000084396" ] }, "reaction_10329573": { "compartment": "compartment_70101", "id": "reaction_10329573", "reactome": "R-XTR-5339535", "name": "GLTPD1 transports C1P from plasma membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1638840" ], "products": [ "species_5339515" ], "modifiers": [ [ "species_10329570", "catalyst" ] ], "additional_components": [ "ENSXETT00000024361" ] }, "reaction_10323888": { "compartment": "compartment_161320", "id": "reaction_10323888", "reactome": "R-XTR-1606564", "name": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1606573" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10323885", "catalyst" ] ], "additional_components": [ "ENSXETG00000016608" ] }, "reaction_10323922": { "compartment": "compartment_876", "id": "reaction_10323922", "reactome": "R-XTR-1638845", "name": "CERK phosphorylates CERA to form C1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_113592" ], "products": [ "species_29370", "species_1638840" ], "modifiers": [ [ "species_10323919", "catalyst" ] ], "additional_components": [ "ENSXETG00000030525" ] }, "reaction_10318077": { "compartment": "compartment_70101", "id": "reaction_10318077", "reactome": "R-XTR-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_428126", "species_29368" ], "products": [ "species_428218", "species_29356", "species_428256" ], "modifiers": [ [ "species_10318074", "catalyst" ] ], "additional_components": [ "species_73473", "species_113600", "species_29360", "species_113563", "ENSXETT00000040228" ] }, "reaction_10318094": { "compartment": "compartment_70101", "id": "reaction_10318094", "reactome": "R-XTR-428701", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10318088", "catalyst" ] ], "additional_components": [ "ENSXETG00000030642" ] }, "reaction_10318091": { "compartment": "compartment_70101", "id": "reaction_10318091", "reactome": "R-XTR-428664", "name": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428275" ], "products": [ "species_29372", "species_428694" ], "modifiers": [ [ "species_10318088", "catalyst" ] ], "additional_components": [ "ENSXETG00000030642" ] }, "reaction_10336999": { "compartment": "compartment_12045", "id": "reaction_10336999", "reactome": "R-XTR-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959490", "species_8959486" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10336996", "catalyst" ] ], "additional_components": [ "ENSXETT00000042961" ] }, "reaction_10318070": { "compartment": "compartment_70101", "id": "reaction_10318070", "reactome": "R-XTR-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_428163" ], "products": [ "species_428126", "species_76194" ], "modifiers": [ [ "species_10318067", "catalyst" ] ], "additional_components": [ "ENSXETT00000029263" ] }, "reaction_10331218": { "compartment": "compartment_12045", "id": "reaction_10331218", "reactome": "R-XTR-5692261", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428671", "species_29360" ], "products": [ "species_70106", "species_3632881", "species_73473" ], "modifiers": [ [ "species_10331215", "catalyst" ] ], "additional_components": [ "F6X8Y6", "ENSXETT00000029530" ] }, "reaction_10314156": { "compartment": "compartment_70101", "id": "reaction_10314156", "reactome": "R-XTR-191303", "name": "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191409", "species_191362" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10314153", "catalyst" ] ], "additional_components": [ "species_109496", "A0A6I8QKN8", "ENSXETG00000040625" ] }, "reaction_10314159": { "compartment": "compartment_70101", "id": "reaction_10314159", "reactome": "R-XTR-191322", "name": "Addition of isopentenyl pyrophosphate to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191324", "species_191362" ], "products": [ "species_111294", "species_191409" ], "modifiers": [ [ "species_10314153", "catalyst" ] ], "additional_components": [ "species_109496", "A0A6I8QKN8", "ENSXETG00000040625" ] }, "reaction_10314175": { "compartment": "compartment_70101", "id": "reaction_10314175", "reactome": "R-XTR-191366", "name": "Squalene 2,3-epoxide cyclizes, forming lanosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191309" ], "products": [ "species_194634" ], "modifiers": [ [ "species_10314172", "catalyst" ] ], "additional_components": [ "ENSXETT00000043201" ] }, "reaction_10314168": { "compartment": "compartment_70101", "id": "reaction_10314168", "reactome": "R-XTR-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374", "species_70106", "species_29364" ], "products": [ "species_29366", "species_76194", "species_191424" ], "modifiers": [ [ "species_10314165", "catalyst" ] ], "additional_components": [ "A0A6I8REP9", "ENSXETG00000005084" ] }, "reaction_10314315": { "compartment": "compartment_13231", "id": "reaction_10314315", "reactome": "R-XTR-194674", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194681", "species_194725", "species_194688" ], "products": [ "species_194668", "species_194704" ], "modifiers": [ [ "species_10314312", "catalyst" ] ], "additional_components": [ "ENSXETG00000034786" ] }, "reaction_10329482": { "compartment": "compartment_17957", "id": "reaction_10329482", "reactome": "R-XTR-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10329479", "catalyst" ] ], "additional_components": [ "ENSXETT00000055609" ] }, "reaction_10314344": { "compartment": "compartment_70101", "id": "reaction_10314344", "reactome": "R-XTR-196417", "name": "Reduction of desmosterol to cholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_196420", "species_29364" ], "products": [ "species_193384", "species_29366" ], "modifiers": [ [ "species_10314341", "catalyst" ] ], "additional_components": [ "ENSXETG00000020010" ] }, "reaction_10314337": { "compartment": "compartment_70101", "id": "reaction_10314337", "reactome": "R-XTR-196402", "name": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_195655", "species_29364" ], "products": [ "species_29366", "species_196420" ], "modifiers": [ [ "species_10314334", "catalyst" ] ], "additional_components": [ "ENSXETG00000008945" ] }, "reaction_10314322": { "compartment": "compartment_70101", "id": "reaction_10314322", "reactome": "R-XTR-195664", "name": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_195691", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_195655" ], "modifiers": [ [ "species_10314319", "catalyst" ] ], "additional_components": [ "ENSXETG00000040073" ] }, "reaction_10336886": { "compartment": "compartment_70101", "id": "reaction_10336886", "reactome": "R-XTR-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_191265" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10336883", "catalyst" ] ], "additional_components": [ "ENSXETT00000041334" ] }, "reaction_10335903": { "compartment": "compartment_70101", "id": "reaction_10335903", "reactome": "R-XTR-8873850", "name": "STARD5 binds DCA, LCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_10335899", "species_5357505" ], "products": [ "species_10335901" ], "modifiers": [], "additional_components": [ "ENSXETG00000030995", "species_5357505", "A0A6I8PZC4", "ENSXETG00000030995", "species_176655" ] }, "reaction_10313015": { "compartment": "compartment_70101", "id": "reaction_10313015", "reactome": "R-XTR-159431", "name": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194073", "species_194069" ], "products": [ "species_193416", "species_76194" ], "modifiers": [ [ "species_10313012", "catalyst" ] ], "additional_components": [ "species_192356", "species_193472", "species_159549", "CHEBI:15891", "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:28865", "ENSXETT00000000095" ] }, "reaction_10335837": { "compartment": "compartment_70101", "id": "reaction_10335837", "reactome": "R-XTR-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10335834", "catalyst" ] ], "additional_components": [ "Q0IJ05", "ENSXETG00000002831", "A0A6I8SCX9", "ENSXETG00000015011" ] }, "reaction_10314190": { "compartment": "compartment_5460", "id": "reaction_10314190", "reactome": "R-XTR-191999", "name": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_192078", "species_113529", "species_113600" ], "products": [ "species_192201", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314213": { "compartment": "compartment_5460", "id": "reaction_10314213", "reactome": "R-XTR-192042", "name": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192201", "species_113563" ], "products": [ "species_113529", "species_191968", "species_113600" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314261": { "compartment": "compartment_17951", "id": "reaction_10314261", "reactome": "R-XTR-193491", "name": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193463", "species_193472" ], "products": [ "species_193453", "species_193514" ], "modifiers": [ [ "species_10314228", "catalyst" ] ], "additional_components": [ "species_159549", "CHEBI:15891", "CHEBI:36274", "CHEBI:16525", "ENSXETT00000000095" ] }, "reaction_10314263": { "compartment": "compartment_5460", "id": "reaction_10314263", "reactome": "R-XTR-193497", "name": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_193387" ], "products": [ "species_193435", "species_113529", "species_113600" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314215": { "compartment": "compartment_5460", "id": "reaction_10314215", "reactome": "R-XTR-192054", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_191968", "species_113600" ], "products": [ "species_113563", "species_192161", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314231": { "compartment": "compartment_17951", "id": "reaction_10314231", "reactome": "R-XTR-192312", "name": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192356", "species_193463" ], "products": [ "species_193404", "species_193514" ], "modifiers": [ [ "species_10314228", "catalyst" ] ], "additional_components": [ "species_159549", "CHEBI:15891", "CHEBI:17687", "CHEBI:28865", "ENSXETT00000000095" ] }, "reaction_10314257": { "compartment": "compartment_5460", "id": "reaction_10314257", "reactome": "R-XTR-193393", "name": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193436", "species_113533", "species_113529", "species_113600" ], "products": [ "species_113563", "species_193387", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314211": { "compartment": "compartment_70101", "id": "reaction_10314211", "reactome": "R-XTR-192036", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192064" ], "products": [ "species_29366", "species_192087" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10314259": { "compartment": "compartment_5460", "id": "reaction_10314259", "reactome": "R-XTR-193460", "name": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_193435", "species_113529", "species_113600" ], "products": [ "species_113563", "species_193440", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314226": { "compartment": "compartment_70101", "id": "reaction_10314226", "reactome": "R-XTR-192160", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191980", "species_70106", "species_29364" ], "products": [ "species_192030", "species_29366" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10335848": { "compartment": "compartment_70101", "id": "reaction_10335848", "reactome": "R-XTR-8868402", "name": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399", "species_1806217" ], "products": [ "species_8868393", "species_1806234" ], "modifiers": [ [ "species_10335845", "catalyst" ] ], "additional_components": [ "ENSXETG00000020714" ] }, "reaction_10314269": { "compartment": "compartment_5460", "id": "reaction_10314269", "reactome": "R-XTR-193719", "name": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193708", "species_113533", "species_113529", "species_113600" ], "products": [ "species_113563", "species_193716", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314271": { "compartment": "compartment_5460", "id": "reaction_10314271", "reactome": "R-XTR-193737", "name": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_193716", "species_113600" ], "products": [ "species_193757", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314281": { "compartment": "compartment_5460", "id": "reaction_10314281", "reactome": "R-XTR-193792", "name": "CYP27A1 27-hydroxylates 5-CHOL3,7,24(s)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_193720", "species_113529", "species_113600" ], "products": [ "species_193708", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314267": { "compartment": "compartment_5460", "id": "reaction_10314267", "reactome": "R-XTR-193713", "name": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_193785", "species_113529", "species_113600" ], "products": [ "species_113563", "species_193747", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314277": { "compartment": "compartment_70101", "id": "reaction_10314277", "reactome": "R-XTR-193781", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193707", "species_29364" ], "products": [ "species_29366", "species_193728" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10314279": { "compartment": "compartment_5460", "id": "reaction_10314279", "reactome": "R-XTR-193787", "name": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_193777", "species_113600" ], "products": [ "species_113563", "species_193782", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314273": { "compartment": "compartment_70101", "id": "reaction_10314273", "reactome": "R-XTR-193758", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193760" ], "products": [ "species_29366", "species_213285" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10314275": { "compartment": "compartment_5460", "id": "reaction_10314275", "reactome": "R-XTR-193780", "name": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_193782", "species_113600" ], "products": [ "species_193785", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314285": { "compartment": "compartment_70101", "id": "reaction_10314285", "reactome": "R-XTR-193841", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193830" ], "products": [ "species_29366", "species_193842" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10314283": { "compartment": "compartment_70101", "id": "reaction_10314283", "reactome": "R-XTR-193800", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193829", "species_29364" ], "products": [ "species_29366", "species_193843" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10331300": { "compartment": "compartment_70101", "id": "reaction_10331300", "reactome": "R-XTR-5693390", "name": "HSD17B11 dehydrogenates EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193132", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10331297", "catalyst" ] ], "additional_components": [ "ENSXETT00000002941" ] }, "reaction_10334610": { "compartment": "compartment_70101", "id": "reaction_10334610", "reactome": "R-XTR-6810594", "name": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176619", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10334607", "catalyst" ] ], "additional_components": [ "A0A6I8S4B9", "ENSXETG00000035086" ] }, "reaction_10314330": { "compartment": "compartment_70616", "id": "reaction_10314330", "reactome": "R-XTR-196086", "name": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314328" ], "products": [ "species_10314326", "species_193156" ], "modifiers": [], "additional_components": [ "species_216762", "F7C998", "ENSXETT00000006725", "ENSXETT00000006725" ] }, "reaction_10338216": { "compartment": "compartment_70101", "id": "reaction_10338216", "reactome": "R-XTR-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10328552", "catalyst" ] ], "additional_components": [ "ENSXETG00000021063" ] }, "reaction_10338213": { "compartment": "compartment_70101", "id": "reaction_10338213", "reactome": "R-XTR-9705713", "name": "SRD5A2 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10338210", "catalyst" ] ], "additional_components": [ "ENSXETG00000025082" ] }, "reaction_10314308": { "compartment": "compartment_17957", "id": "reaction_10314308", "reactome": "R-XTR-194023", "name": "HSD11B2,HSD11B1 dimer oxidise CORT to COR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193977", "species_29366" ], "products": [ "species_70106", "species_29364", "species_194035" ], "modifiers": [ [ "species_10314305", "catalyst" ] ], "additional_components": [ "A4IGM4", "ENSXETT00000031363" ] }, "reaction_10322500": { "compartment": "compartment_984", "id": "reaction_10322500", "reactome": "R-XTR-1449687", "name": "Corticosteroids bind to CBG in blood", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1449707", "species_10322496" ], "products": [ "species_10322498" ], "modifiers": [], "additional_components": [ "species_193982", "CHEBI:17026", "species_194011", "species_193988", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350", "A0A6I8QL92", "ENSXETG00000039008", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350", "A0A6I8QL92", "ENSXETG00000039008", "species_193982", "CHEBI:17026", "species_194011", "species_193988" ] }, "reaction_10319038": { "compartment": "compartment_70101", "id": "reaction_10319038", "reactome": "R-XTR-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_548836", "species_29366" ], "modifiers": [ [ "species_10319035", "catalyst" ] ], "additional_components": [ "ENSXETT00000048094" ] }, "reaction_10315643": { "compartment": "compartment_70101", "id": "reaction_10315643", "reactome": "R-XTR-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3632881", "species_76194" ], "products": [ "species_111294", "species_29356", "species_200993", "species_76577" ], "modifiers": [ [ "species_10315640", "catalyst" ] ], "additional_components": [ "ENSXETG00000016588" ] }, "reaction_10319031": { "compartment": "compartment_70101", "id": "reaction_10319031", "reactome": "R-XTR-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_113528", "species_548812", "species_76194" ], "modifiers": [ [ "species_10319028", "catalyst" ] ], "additional_components": [ "ENSXETG00000035907" ] }, "reaction_10319024": { "compartment": "compartment_70101", "id": "reaction_10319024", "reactome": "R-XTR-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_29508" ], "products": [ "species_113528", "species_548816", "species_76194" ], "modifiers": [ [ "species_10319021", "catalyst" ] ], "additional_components": [ "ENSXETT00000034904" ] }, "reaction_10330576": { "compartment": "compartment_12045", "id": "reaction_10330576", "reactome": "R-XTR-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_29356", "species_5676634" ], "modifiers": [ [ "species_10330573", "catalyst" ] ], "additional_components": [ "A0A6I8T2J8", "ENSXETG00000040752" ] }, "reaction_10334601": { "compartment": "compartment_17951", "id": "reaction_10334601", "reactome": "R-XTR-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10334598", "catalyst" ] ], "additional_components": [ "ENSXETT00000054418" ] }, "reaction_10334696": { "compartment": "compartment_17947", "id": "reaction_10334696", "reactome": "R-XTR-8848247", "name": "ACBD4,5 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690520", "species_10334692" ], "products": [ "species_10334694" ], "modifiers": [], "additional_components": [ "CHEBI:33184", "CHEBI:61907", "Q640U0", "ENSXETT00000040674", "Q640U0", "ENSXETT00000040674", "CHEBI:33184", "CHEBI:61907" ] }, "reaction_10317404": { "compartment": "compartment_17947", "id": "reaction_10317404", "reactome": "R-XTR-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10317281", "catalyst" ] ], "additional_components": [ "A0A6I8Q353", "ENSXETG00000007705" ] }, "reaction_10330926": { "compartment": "compartment_17951", "id": "reaction_10330926", "reactome": "R-XTR-5690042", "name": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690520", "species_141343" ], "products": [ "species_5690539", "species_193514" ], "modifiers": [ [ "species_10330921", "catalyst" ] ], "additional_components": [ "CHEBI:33184", "CHEBI:61907", "CHEBI:59554", "species_30495", "ENSXETT00000000095" ] }, "reaction_10334585": { "compartment": "compartment_17951", "id": "reaction_10334585", "reactome": "R-XTR-6809808", "name": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6809801" ], "products": [ "species_6809800" ], "modifiers": [ [ "species_10334582", "catalyst" ] ], "additional_components": [ "A0A6I8RBB6", "ENSXETG00000032831" ] }, "reaction_10332329": { "compartment": "compartment_17951", "id": "reaction_10332329", "reactome": "R-XTR-6786720", "name": "DECR2 reduces LCtE-CoA to t3enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193465", "species_6786723", "species_113602" ], "products": [ "species_6786715", "species_389556" ], "modifiers": [ [ "species_10332326", "catalyst" ] ], "additional_components": [ "ENSXETT00000022727" ] }, "reaction_10334554": { "compartment": "compartment_17951", "id": "reaction_10334554", "reactome": "R-XTR-6809264", "name": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10334548", "catalyst" ] ], "additional_components": [ "ENSXETT00000023381" ] }, "reaction_10334551": { "compartment": "compartment_17951", "id": "reaction_10334551", "reactome": "R-XTR-6809263", "name": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_390249" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10334548", "catalyst" ] ], "additional_components": [ "ENSXETT00000023381" ] }, "reaction_10320834": { "compartment": "compartment_17951", "id": "reaction_10320834", "reactome": "R-XTR-977317", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977323" ], "products": [ "species_353123", "species_389536" ], "modifiers": [ [ "species_10320831", "catalyst" ] ], "additional_components": [ "ENSXETG00000013233" ] }, "reaction_10317365": { "compartment": "compartment_17951", "id": "reaction_10317365", "reactome": "R-XTR-389609", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389636", "species_192307" ], "products": [ "species_193465", "species_6811612", "species_192305" ], "modifiers": [ [ "species_10317362", "catalyst" ] ], "additional_components": [ "F6X8Y6", "ENSXETT00000029530" ] }, "reaction_10317391": { "compartment": "compartment_17951", "id": "reaction_10317391", "reactome": "R-XTR-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10317388", "catalyst" ] ], "additional_components": [ "species_113596", "A0A6I8PRN9", "ENSXETG00000031495" ] }, "reaction_10325882": { "compartment": "compartment_12045", "id": "reaction_10325882", "reactome": "R-XTR-2046100", "name": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046059", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046057", "species_162743", "species_159751" ], "modifiers": [ [ "species_10319021", "catalyst" ] ], "additional_components": [ "ENSXETT00000034904" ] }, "reaction_10325876": { "compartment": "compartment_17957", "id": "reaction_10325876", "reactome": "R-XTR-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046051", "species_162743", "species_159751" ], "modifiers": [ [ "species_10319021", "catalyst" ] ], "additional_components": [ "ENSXETT00000034904" ] }, "reaction_10325874": { "compartment": "compartment_17957", "id": "reaction_10325874", "reactome": "R-XTR-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_426639", "species_211606", "species_2046047" ], "modifiers": [ [ "species_10317279", "catalyst" ] ], "additional_components": [ "ENSXETG00000007705" ] }, "reaction_10326111": { "compartment": "compartment_12045", "id": "reaction_10326111", "reactome": "R-XTR-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2142739" ], "modifiers": [ [ "species_10326101", "catalyst" ] ], "additional_components": [ "A0A6I8SJ30", "ENSXETG00000038590", "A4IGV4", "ENSXETT00000061279" ] }, "reaction_10326116": { "compartment": "compartment_12045", "id": "reaction_10326116", "reactome": "R-XTR-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_2161753", "species_29366" ], "modifiers": [ [ "species_10326113", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "A0A6I8SJ30", "ENSXETG00000038590", "A0A6I8PUP3", "ENSXETG00000033706", "A4IGV4", "ENSXETT00000061279" ] }, "reaction_10326136": { "compartment": "compartment_70101", "id": "reaction_10326136", "reactome": "R-XTR-2161950", "name": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2142790" ], "modifiers": [ [ "species_10326133", "catalyst" ] ], "additional_components": [ "species_435347", "A0A6I8QVI1", "ENSXETG00000018683", "A0A6I8R9T5", "ENSXETG00000000004" ] }, "reaction_10336762": { "compartment": "compartment_70101", "id": "reaction_10336762", "reactome": "R-XTR-8942208", "name": "ALOXE3 isomerises 12R-HpETE to HXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142790" ], "products": [ "species_8942209" ], "modifiers": [ [ "species_10336759", "catalyst" ] ], "additional_components": [ "A0A6I8R9T5", "ENSXETG00000000004", "A0A6I8QVI1", "ENSXETG00000018683" ] }, "reaction_10331492": { "compartment": "compartment_12045", "id": "reaction_10331492", "reactome": "R-XTR-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192172", "species_5696426" ], "products": [ "species_5696412", "species_162743" ], "modifiers": [ [ "species_10331489", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10326094": { "compartment": "compartment_70101", "id": "reaction_10326094", "reactome": "R-XTR-2161614", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_879629" ], "products": [ "species_29366", "species_2142710" ], "modifiers": [ [ "species_10314206", "catalyst" ] ], "additional_components": [ "A0A6I8R8Y6", "ENSXETG00000040684", "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10326091": { "compartment": "compartment_70101", "id": "reaction_10326091", "reactome": "R-XTR-2161549", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_265283", "species_29364" ], "products": [ "species_29366", "species_879535" ], "modifiers": [ [ "species_10314206", "catalyst" ] ], "additional_components": [ "A0A6I8R8Y6", "ENSXETG00000040684", "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10326099": { "compartment": "compartment_70101", "id": "reaction_10326099", "reactome": "R-XTR-2161701", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_879629" ], "modifiers": [ [ "species_10326096", "catalyst" ] ], "additional_components": [ "F6SJ37", "ENSXETT00000045440", "species_1247892" ] }, "reaction_10326143": { "compartment": "compartment_70101", "id": "reaction_10326143", "reactome": "R-XTR-2162002", "name": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2142718" ], "modifiers": [ [ "species_10326140", "catalyst" ] ], "additional_components": [ "A0A6I8QVI1", "ENSXETG00000018683", "species_435347" ] }, "reaction_10312563": { "compartment": "compartment_12045", "id": "reaction_10312563", "reactome": "R-XTR-111883", "name": "Hydrolysis of phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_140356", "species_428981" ], "modifiers": [ [ "species_10312558", "catalyst" ] ], "additional_components": [ "B1WAZ6", "ENSXETT00000066288", "species_74112", "species_426925" ] }, "reaction_10335800": { "compartment": "compartment_70101", "id": "reaction_10335800", "reactome": "R-XTR-8866941", "name": "MID1IP1 binds THRSP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335794", "species_10335796" ], "products": [ "species_10335798" ], "modifiers": [], "additional_components": [ "ENSXETT00000087898", "ENSXETT00000087898", "Q6P8B2", "ENSXETT00000087898" ] }, "reaction_10315632": { "compartment": "compartment_70616", "id": "reaction_10315632", "reactome": "R-XTR-200410", "name": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_201050" ], "products": [ "species_201023", "species_77281" ], "modifiers": [ [ "species_10315629", "catalyst" ] ], "additional_components": [ "ENSXETT00000017686" ] }, "reaction_10330939": { "compartment": "compartment_70101", "id": "reaction_10330939", "reactome": "R-XTR-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5690044" ], "products": [ "species_5690064", "species_76194" ], "modifiers": [ [ "species_10330936", "catalyst" ] ], "additional_components": [ "CHEBI:61907", "CHEBI:33184", "CHEBI:59554", "species_30495", "Q6DER5", "ENSXETT00000054972", "F6UBG9", "ENSXETT00000000095" ] }, "reaction_10330950": { "compartment": "compartment_5460", "id": "reaction_10330950", "reactome": "R-XTR-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10330947", "catalyst" ] ], "additional_components": [ "CHEBI:33184", "CHEBI:61907", "species_30495", "CHEBI:59554", "F6UBG9", "ENSXETT00000000095", "A0A6I8RQ71", "ENSXETG00000036041" ] }, "reaction_10336900": { "compartment": "compartment_5460", "id": "reaction_10336900", "reactome": "R-XTR-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113529", "species_113600" ], "products": [ "species_77308", "species_113563" ], "modifiers": [ [ "species_10336897", "catalyst" ] ], "additional_components": [ "Q28GQ2", "ENSXETT00000031439" ] }, "reaction_10324062": { "compartment": "compartment_876", "id": "reaction_10324062", "reactome": "R-XTR-1676164", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10324057", "catalyst" ] ], "additional_components": [ "ENSXETG00000019407" ] }, "reaction_10324025": { "compartment": "compartment_876", "id": "reaction_10324025", "reactome": "R-XTR-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10324015", "catalyst" ] ], "additional_components": [ "ENSXETG00000009899" ] }, "reaction_10323994": { "compartment": "compartment_876", "id": "reaction_10323994", "reactome": "R-XTR-1675780", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_392417" ], "modifiers": [ [ "species_10323991", "catalyst" ] ], "additional_components": [ "Q28G26", "ENSXETG00000000962", "Q505I0", "ENSXETG00000013516" ] }, "reaction_10324053": { "compartment": "compartment_876", "id": "reaction_10324053", "reactome": "R-XTR-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10323969", "catalyst" ] ], "additional_components": [ "ENSXETT00000042073" ] }, "reaction_10324020": { "compartment": "compartment_876", "id": "reaction_10324020", "reactome": "R-XTR-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10324015", "catalyst" ] ], "additional_components": [ "ENSXETG00000009899" ] }, "reaction_10324048": { "compartment": "compartment_876", "id": "reaction_10324048", "reactome": "R-XTR-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10312068", "catalyst" ] ], "additional_components": [ "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252" ] }, "reaction_10323981": { "compartment": "compartment_876", "id": "reaction_10323981", "reactome": "R-XTR-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806240", "species_113592" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10323978", "catalyst" ] ], "additional_components": [ "Q6GL14", "ENSXETG00000006229" ] }, "reaction_10324043": { "compartment": "compartment_876", "id": "reaction_10324043", "reactome": "R-XTR-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10323969", "catalyst" ] ], "additional_components": [ "ENSXETT00000042073" ] }, "reaction_10324037": { "compartment": "compartment_876", "id": "reaction_10324037", "reactome": "R-XTR-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10312068", "catalyst" ] ], "additional_components": [ "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252" ] }, "reaction_10323972": { "compartment": "compartment_876", "id": "reaction_10323972", "reactome": "R-XTR-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10323969", "catalyst" ] ], "additional_components": [ "ENSXETT00000042073" ] }, "reaction_10324070": { "compartment": "compartment_876", "id": "reaction_10324070", "reactome": "R-XTR-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10324031", "catalyst" ] ], "additional_components": [ "A0A6I8QJY3", "ENSXETG00000016428", "A0A6I8RPT3", "ENSXETG00000009899" ] }, "reaction_10324065": { "compartment": "compartment_876", "id": "reaction_10324065", "reactome": "R-XTR-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10324015", "catalyst" ] ], "additional_components": [ "ENSXETG00000009899" ] }, "reaction_10324034": { "compartment": "compartment_876", "id": "reaction_10324034", "reactome": "R-XTR-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10324031", "catalyst" ] ], "additional_components": [ "A0A6I8QJY3", "ENSXETG00000016428", "A0A6I8RPT3", "ENSXETG00000009899" ] }, "reaction_10324045": { "compartment": "compartment_171062", "id": "reaction_10324045", "reactome": "R-XTR-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806205" ], "products": [ "species_29372", "species_1806259" ], "modifiers": [ [ "species_10323998", "catalyst" ] ], "additional_components": [ "ENSXETT00000011460" ] }, "reaction_10324060": { "compartment": "compartment_171062", "id": "reaction_10324060", "reactome": "R-XTR-1676162", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806238" ], "products": [ "species_29372", "species_1806200" ], "modifiers": [ [ "species_10324057", "catalyst" ] ], "additional_components": [ "ENSXETG00000019407" ] }, "reaction_10324022": { "compartment": "compartment_171062", "id": "reaction_10324022", "reactome": "R-XTR-1675974", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_1806180", "species_29370" ], "modifiers": [ [ "species_10323991", "catalyst" ] ], "additional_components": [ "Q28G26", "ENSXETG00000000962", "Q505I0", "ENSXETG00000013516" ] }, "reaction_10324050": { "compartment": "compartment_171062", "id": "reaction_10324050", "reactome": "R-XTR-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10323998", "catalyst" ] ], "additional_components": [ "ENSXETT00000011460" ] }, "reaction_10334562": { "compartment": "compartment_70101", "id": "reaction_10334562", "reactome": "R-XTR-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334558", "species_10323998" ], "products": [ "species_10334560" ], "modifiers": [], "additional_components": [ "ENSXETG00000015585", "ENSXETT00000011460", "F6VED7", "ENSXETT00000011460", "A0A6I8R2K2", "ENSXETG00000015585" ] }, "reaction_10334573": { "compartment": "compartment_70101", "id": "reaction_10334573", "reactome": "R-XTR-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5676030" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10334568", "catalyst" ] ], "additional_components": [ "F6VED7", "ENSXETT00000011460", "A0A6I8Q167", "ENSXETG00000023079" ] }, "reaction_10334570": { "compartment": "compartment_70101", "id": "reaction_10334570", "reactome": "R-XTR-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334566", "species_10323998" ], "products": [ "species_10334568" ], "modifiers": [], "additional_components": [ "ENSXETG00000023079", "ENSXETT00000011460", "F6VED7", "ENSXETT00000011460", "A0A6I8Q167", "ENSXETG00000023079" ] }, "reaction_10324004": { "compartment": "compartment_12045", "id": "reaction_10324004", "reactome": "R-XTR-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10323989", "catalyst" ] ], "additional_components": [ "ENSXETG00000000962" ] }, "reaction_10334576": { "compartment": "compartment_70101", "id": "reaction_10334576", "reactome": "R-XTR-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6809774" ], "products": [ "species_29372", "species_422529" ], "modifiers": [ [ "species_10334568", "catalyst" ] ], "additional_components": [ "F6VED7", "ENSXETT00000011460", "A0A6I8Q167", "ENSXETG00000023079" ] }, "reaction_10324011": { "compartment": "compartment_20699", "id": "reaction_10324011", "reactome": "R-XTR-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_29372", "species_1806217" ], "modifiers": [ [ "species_10324008", "catalyst" ] ], "additional_components": [ "ENSXETG00000038322" ] }, "reaction_10324067": { "compartment": "compartment_20699", "id": "reaction_10324067", "reactome": "R-XTR-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10323991", "catalyst" ] ], "additional_components": [ "Q28G26", "ENSXETG00000000962", "Q505I0", "ENSXETG00000013516" ] }, "reaction_10335920": { "compartment": "compartment_437051", "id": "reaction_10335920", "reactome": "R-XTR-8874470", "name": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8874484" ], "products": [ "species_8874460" ], "modifiers": [ [ "species_10335917", "catalyst" ] ], "additional_components": [ "species_179838", "species_179856", "species_179856", "species_179838", "A0A6I8R443", "ENSXETG00000036250" ] }, "reaction_10324040": { "compartment": "compartment_172574", "id": "reaction_10324040", "reactome": "R-XTR-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10323998", "catalyst" ] ], "additional_components": [ "ENSXETT00000011460" ] }, "reaction_10324001": { "compartment": "compartment_172574", "id": "reaction_10324001", "reactome": "R-XTR-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_29372", "species_1806195" ], "modifiers": [ [ "species_10323998", "catalyst" ] ], "additional_components": [ "ENSXETT00000011460" ] }, "reaction_10335862": { "compartment": "compartment_70101", "id": "reaction_10335862", "reactome": "R-XTR-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_1602448" ], "products": [ "species_426755", "species_426658" ], "modifiers": [ [ "species_10335859", "catalyst" ] ], "additional_components": [ "ENSXETG00000020679" ] }, "reaction_10323390": { "compartment": "compartment_70101", "id": "reaction_10323390", "reactome": "R-XTR-1483096", "name": "PETA is dephosphorylated to ETA by PHOSPHO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428686" ], "products": [ "species_29372", "species_1498751" ], "modifiers": [ [ "species_10323387", "catalyst" ] ], "additional_components": [ "A0A6I8PRS6", "ENSXETG00000033588", "species_109496" ] }, "reaction_10323403": { "compartment": "compartment_70101", "id": "reaction_10323403", "reactome": "R-XTR-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10323371", "catalyst" ] ], "additional_components": [ "A0A6I8PNM3", "ENSXETG00000031132" ] }, "reaction_10323365": { "compartment": "compartment_12045", "id": "reaction_10323365", "reactome": "R-XTR-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_1500581", "species_109395" ], "modifiers": [ [ "species_10323362", "catalyst" ] ], "additional_components": [ "Q28H54", "ENSXETT00000009560", "species_109496", "CHEBI:29035", "A0A6I8QF66", "ENSXETG00000036824" ] }, "reaction_10323400": { "compartment": "compartment_12045", "id": "reaction_10323400", "reactome": "R-XTR-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_264618", "species_1500646" ], "modifiers": [ [ "species_10323397", "catalyst" ] ], "additional_components": [ "ENSXETG00000036605" ] }, "reaction_10323381": { "compartment": "compartment_12045", "id": "reaction_10323381", "reactome": "R-XTR-1483089", "name": "PE is converted to PS by PTDSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_1500581" ], "products": [ "species_1498751", "species_1500646" ], "modifiers": [ [ "species_10323378", "catalyst" ] ], "additional_components": [ "ENSXETG00000027078" ] }, "reaction_10323309": { "compartment": "compartment_70616", "id": "reaction_10323309", "reactome": "R-XTR-1482794", "name": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524072", "species_1524079" ], "products": [ "species_1524075", "species_1498773" ], "modifiers": [ [ "species_10323303", "catalyst" ] ], "additional_components": [ "ENSXETT00000007327" ] }, "reaction_10323341": { "compartment": "compartment_70616", "id": "reaction_10323341", "reactome": "R-XTR-1482894", "name": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524072", "species_1524089" ], "products": [ "species_1524083", "species_1498773" ], "modifiers": [ [ "species_10323303", "catalyst" ] ], "additional_components": [ "ENSXETT00000007327" ] }, "reaction_10323290": { "compartment": "compartment_70616", "id": "reaction_10323290", "reactome": "R-XTR-1482759", "name": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_113521" ], "products": [ "species_1498753", "species_1524085" ], "modifiers": [ [ "species_10323287", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323332": { "compartment": "compartment_12045", "id": "reaction_10323332", "reactome": "R-XTR-1482867", "name": "DLCL is acylated to MLCL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524080", "species_1500578" ], "products": [ "species_76194", "species_1524069" ], "modifiers": [ [ "species_10312131", "catalyst" ] ], "additional_components": [ "ENSXETT00000031524" ] }, "reaction_10323328": { "compartment": "compartment_12045", "id": "reaction_10323328", "reactome": "R-XTR-1482861", "name": "MLCL is acylated to CL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1524069" ], "products": [ "species_1524081", "species_76194" ], "modifiers": [ [ "species_10312131", "catalyst" ] ], "additional_components": [ "ENSXETT00000031524" ] }, "reaction_10331497": { "compartment": "compartment_12045", "id": "reaction_10331497", "reactome": "R-XTR-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10331494", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10323338": { "compartment": "compartment_12045", "id": "reaction_10323338", "reactome": "R-XTR-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10319042", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10334710": { "compartment": "compartment_12045", "id": "reaction_10334710", "reactome": "R-XTR-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10334707", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10323276": { "compartment": "compartment_12045", "id": "reaction_10323276", "reactome": "R-XTR-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498722" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323343": { "compartment": "compartment_12045", "id": "reaction_10323343", "reactome": "R-XTR-1482897", "name": "PS is hydrolyzed to 2-acyl LPS by PLA2[10]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500646" ], "products": [ "species_1498722", "species_1524021" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323299": { "compartment": "compartment_12045", "id": "reaction_10323299", "reactome": "R-XTR-1482771", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[9]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500646" ], "products": [ "species_1524021", "species_1498724" ], "modifiers": [ [ "species_10323296", "catalyst" ] ], "additional_components": [ "A0A6I8PMU8", "ENSXETG00000029956", "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323266": { "compartment": "compartment_12045", "id": "reaction_10323266", "reactome": "R-XTR-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498724" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323810": { "compartment": "compartment_984", "id": "reaction_10323810", "reactome": "R-XTR-1602374", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_33625" ], "products": [ "species_1602419", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10336015": { "compartment": "compartment_5460", "id": "reaction_10336015", "reactome": "R-XTR-8878654", "name": "ACP6 hydrolyses MYS-LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8878649", "species_113521" ], "products": [ "species_113548", "species_8934414" ], "modifiers": [ [ "species_10336012", "catalyst" ] ], "additional_components": [ "ENSXETT00000009623" ] }, "reaction_10312153": { "compartment": "compartment_70101", "id": "reaction_10312153", "reactome": "R-XTR-75889", "name": "DHAP is converted to G3P by GPD1/GPD1L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75970", "species_73473" ], "products": [ "species_76114", "species_29360" ], "modifiers": [ [ "species_10312150", "catalyst" ] ], "additional_components": [ "F6XXP1", "ENSXETT00000038446", "Q6P824", "ENSXETT00000032859" ] }, "reaction_10312136": { "compartment": "compartment_12045", "id": "reaction_10312136", "reactome": "R-XTR-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_426755", "species_76194" ], "modifiers": [ [ "species_10312133", "catalyst" ] ], "additional_components": [ "Q28C60", "ENSXETT00000037017", "F7A464", "ENSXETT00000031524" ] }, "reaction_10323256": { "compartment": "compartment_17906", "id": "reaction_10323256", "reactome": "R-XTR-1482604", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500590" ], "products": [ "species_1500580", "species_1524103" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10336024": { "compartment": "compartment_984", "id": "reaction_10336024", "reactome": "R-XTR-8878787", "name": "ALPI dimer hydrolyses phosphate monoesters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8878780" ], "products": [ "species_8878776", "species_109277" ], "modifiers": [ [ "species_10336021", "catalyst" ] ], "additional_components": [ "species_29426", "species_74112", "A0A6I8RU07", "ENSXETG00000032063" ] }, "reaction_10332427": { "compartment": "compartment_876", "id": "reaction_10332427", "reactome": "R-XTR-6792445", "name": "LIPH, I hydrolyse PA to 2-acyl LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602448" ], "products": [ "species_6792472", "species_1602366" ], "modifiers": [ [ "species_10332424", "catalyst" ] ], "additional_components": [ "Q5XGE9", "ENSXETG00000005849", "F6XB15", "ENSXETT00000048464", "L7N2H3", "ENSXETT00000002050" ] }, "reaction_10336954": { "compartment": "compartment_17906", "id": "reaction_10336954", "reactome": "R-XTR-8954398", "name": "PLD6 dimer hydrolyses cardiolipin to PA and PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189422", "species_8954419" ], "products": [ "species_8954401", "species_1500590" ], "modifiers": [ [ "species_10336945", "catalyst" ], [ "species_10336952", "catalyst" ] ], "additional_components": [ "Q28DT3", "ENSXETG00000005747", "A0A6I8QVP8", "ENSXETG00000018962" ] }, "reaction_10323818": { "compartment": "compartment_984", "id": "reaction_10323818", "reactome": "R-XTR-1602446", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602448" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10323270": { "compartment": "compartment_70101", "id": "reaction_10323270", "reactome": "R-XTR-1482656", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323283": { "compartment": "compartment_17906", "id": "reaction_10323283", "reactome": "R-XTR-1482695", "name": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_76194", "species_1500580" ], "modifiers": [ [ "species_10323280", "catalyst" ] ], "additional_components": [ "ENSXETG00000033567" ] }, "reaction_10332322": { "compartment": "compartment_70101", "id": "reaction_10332322", "reactome": "R-XTR-6786650", "name": "DDHD1,2 hydrolyse PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1602448" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10332319", "catalyst" ] ], "additional_components": [ "A0A6I8SK52", "ENSXETG00000015184", "A0A6I8QC54", "ENSXETG00000038294" ] }, "reaction_10323321": { "compartment": "compartment_12045", "id": "reaction_10323321", "reactome": "R-XTR-1482828", "name": "PE is hydrolyzed to 2-acyl LPE by PLA2[4]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498729", "species_1524021" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323336": { "compartment": "compartment_12045", "id": "reaction_10323336", "reactome": "R-XTR-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10323313", "catalyst" ] ], "additional_components": [ "ENSXETG00000015758" ] }, "reaction_10323272": { "compartment": "compartment_12045", "id": "reaction_10323272", "reactome": "R-XTR-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498738" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10335402": { "compartment": "compartment_70101", "id": "reaction_10335402", "reactome": "R-XTR-8858298", "name": "HRASLS transfer acyl group from PC to PE to form NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_1500581" ], "products": [ "species_5694568", "species_6814253" ], "modifiers": [ [ "species_10335399", "catalyst" ] ], "additional_components": [ "A0A6I8PMU8", "ENSXETG00000029956", "A0A6I8SG35", "ENSXETG00000035934", "A0A6I8RYC6", "ENSXETG00000038318", "A0A6I8Q9S3", "ENSXETG00000035934" ] }, "reaction_10323268": { "compartment": "compartment_12045", "id": "reaction_10323268", "reactome": "R-XTR-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323334": { "compartment": "compartment_12045", "id": "reaction_10323334", "reactome": "R-XTR-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10323296", "catalyst" ] ], "additional_components": [ "A0A6I8PMU8", "ENSXETG00000029956", "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323814": { "compartment": "compartment_984", "id": "reaction_10323814", "reactome": "R-XTR-1602398", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602375", "species_109276" ], "products": [ "species_1602372", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10323262": { "compartment": "compartment_12045", "id": "reaction_10323262", "reactome": "R-XTR-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10323248", "catalyst" ] ], "additional_components": [ "ENSXETG00000036938" ] }, "reaction_10323812": { "compartment": "compartment_984", "id": "reaction_10323812", "reactome": "R-XTR-1602377", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_426658" ], "products": [ "species_1602420", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10323318": { "compartment": "compartment_12045", "id": "reaction_10323318", "reactome": "R-XTR-1482825", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[11]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426639" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10323296", "catalyst" ] ], "additional_components": [ "A0A6I8PMU8", "ENSXETG00000029956", "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323251": { "compartment": "compartment_12045", "id": "reaction_10323251", "reactome": "R-XTR-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10323248", "catalyst" ] ], "additional_components": [ "ENSXETG00000036938" ] }, "reaction_10323259": { "compartment": "compartment_12045", "id": "reaction_10323259", "reactome": "R-XTR-1482612", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_975614" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323274": { "compartment": "compartment_12045", "id": "reaction_10323274", "reactome": "R-XTR-1482685", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1524028" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323374": { "compartment": "compartment_70101", "id": "reaction_10323374", "reactome": "R-XTR-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_113592" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10323371", "catalyst" ] ], "additional_components": [ "A0A6I8PNM3", "ENSXETG00000031132" ] }, "reaction_10318360": { "compartment": "compartment_984", "id": "reaction_10318360", "reactome": "R-XTR-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10318357", "catalyst" ] ], "additional_components": [ "ENSXETG00000002987" ] }, "reaction_10323354": { "compartment": "compartment_12045", "id": "reaction_10323354", "reactome": "R-XTR-1482961", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524060", "species_1500596" ], "products": [ "species_426925", "species_109395" ], "modifiers": [ [ "species_10323351", "catalyst" ] ], "additional_components": [ "Q28H54", "ENSXETT00000009560", "species_109496", "CHEBI:29035" ] }, "reaction_10323393": { "compartment": "compartment_70101", "id": "reaction_10323393", "reactome": "R-XTR-1483159", "name": "PCho is dephosphorylated to Cho by PHOSPHO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1524071" ], "products": [ "species_264618", "species_29372" ], "modifiers": [ [ "species_10323387", "catalyst" ] ], "additional_components": [ "A0A6I8PRS6", "ENSXETG00000033588", "species_109496" ] }, "reaction_10335730": { "compartment": "compartment_984", "id": "reaction_10335730", "reactome": "R-XTR-8865637", "name": "MFSD2A transports LPC from extracellular region to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8865642", "species_74113" ], "products": [ "species_8865629", "species_83910" ], "modifiers": [ [ "species_10335727", "catalyst" ] ], "additional_components": [ "ENSXETT00000002564" ] }, "reaction_10323325": { "compartment": "compartment_12045", "id": "reaction_10323325", "reactome": "R-XTR-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10323296", "catalyst" ] ], "additional_components": [ "A0A6I8PMU8", "ENSXETG00000029956", "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323244": { "compartment": "compartment_12045", "id": "reaction_10323244", "reactome": "R-XTR-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323816": { "compartment": "compartment_984", "id": "reaction_10323816", "reactome": "R-XTR-1602417", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_429802" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10323316": { "compartment": "compartment_12045", "id": "reaction_10323316", "reactome": "R-XTR-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10323313", "catalyst" ] ], "additional_components": [ "ENSXETG00000015758" ] }, "reaction_10323239": { "compartment": "compartment_12045", "id": "reaction_10323239", "reactome": "R-XTR-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_975614" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323330": { "compartment": "compartment_12045", "id": "reaction_10323330", "reactome": "R-XTR-1482862", "name": "PC is hydrolysed to 2-acyl LPC by PLA2[7]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524021", "species_975614" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323242": { "compartment": "compartment_12045", "id": "reaction_10323242", "reactome": "R-XTR-1482539", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498740" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323345": { "compartment": "compartment_12045", "id": "reaction_10323345", "reactome": "R-XTR-1482900", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1524021", "species_1498740" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323264": { "compartment": "compartment_12045", "id": "reaction_10323264", "reactome": "R-XTR-1482635", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498730", "species_1500578" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323808": { "compartment": "compartment_984", "id": "reaction_10323808", "reactome": "R-XTR-1602368", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602402" ], "products": [ "species_1602415", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10311977": { "compartment": "compartment_5460", "id": "reaction_10311977", "reactome": "R-XTR-74181", "name": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_73871" ], "products": [ "species_113559" ], "modifiers": [ [ "species_10311582", "catalyst" ] ], "additional_components": [ "Q5BKN8", "ENSXETT00000031684" ] }, "reaction_10311959": { "compartment": "compartment_5460", "id": "reaction_10311959", "reactome": "R-XTR-73920", "name": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_73911" ], "products": [ "species_113529", "species_73909", "species_29362" ], "modifiers": [ [ "species_10311952", "catalyst" ] ], "additional_components": [ "F6RPR3", "ENSXETT00000007485" ] }, "reaction_10331407": { "compartment": "compartment_70101", "id": "reaction_10331407", "reactome": "R-XTR-5694494", "name": "AACS ligates CoA-SH to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_29666" ], "products": [ "species_111294", "species_191293", "species_76577" ], "modifiers": [ [ "species_10331404", "catalyst" ] ], "additional_components": [ "ENSXETG00000001210" ] }, "reaction_10335941": { "compartment": "compartment_5460", "id": "reaction_10335941", "reactome": "R-XTR-8875071", "name": "ACSS3 ligates CoA to CH3COO-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_113539" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10335938", "catalyst" ] ], "additional_components": [ "ENSXETG00000014528" ] }, "reaction_10332359": { "compartment": "compartment_70101", "id": "reaction_10332359", "reactome": "R-XTR-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_76183", "species_29666" ], "modifiers": [ [ "species_10332356", "catalyst" ] ], "additional_components": [ "species_109496", "A0A6I8PVX1", "ENSXETG00000007070" ] }, "reaction_10311955": { "compartment": "compartment_5460", "id": "reaction_10311955", "reactome": "R-XTR-73912", "name": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_73909", "species_29362" ], "products": [ "species_113526", "species_73911" ], "modifiers": [ [ "species_10311952", "catalyst" ] ], "additional_components": [ "F6RPR3", "ENSXETT00000007485" ] }, "reaction_10331506": { "compartment": "compartment_70101", "id": "reaction_10331506", "reactome": "R-XTR-5696457", "name": "BDH2 dehydrogenates 3HBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696461", "species_29360" ], "products": [ "species_70106", "species_29666", "species_73473" ], "modifiers": [ [ "species_10331503", "catalyst" ] ], "additional_components": [ "A0A6I8RES0", "ENSXETG00000021320" ] }, "reaction_10337487": { "compartment": "compartment_70101", "id": "reaction_10337487", "reactome": "R-XTR-9020255", "name": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024765" ], "products": [ "species_9024768", "species_29364" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337499": { "compartment": "compartment_70101", "id": "reaction_10337499", "reactome": "R-XTR-9020282", "name": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024765" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337493": { "compartment": "compartment_70101", "id": "reaction_10337493", "reactome": "R-XTR-9020264", "name": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024797" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337495": { "compartment": "compartment_70101", "id": "reaction_10337495", "reactome": "R-XTR-9020277", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024797" ], "products": [ "species_29364", "species_9024781" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337485": { "compartment": "compartment_70101", "id": "reaction_10337485", "reactome": "R-XTR-9020251", "name": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024463" ], "products": [ "species_9024479" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337497": { "compartment": "compartment_70101", "id": "reaction_10337497", "reactome": "R-XTR-9020278", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024576", "species_29366" ], "products": [ "species_9024577", "species_29364" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337489": { "compartment": "compartment_70101", "id": "reaction_10337489", "reactome": "R-XTR-9020256", "name": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024479" ], "products": [ "species_29364", "species_9024602" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337491": { "compartment": "compartment_70101", "id": "reaction_10337491", "reactome": "R-XTR-9020259", "name": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024463" ], "products": [ "species_9024576" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337534": { "compartment": "compartment_70101", "id": "reaction_10337534", "reactome": "R-XTR-9024997", "name": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025012", "species_29368" ], "products": [ "species_9024989" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337565": { "compartment": "compartment_70101", "id": "reaction_10337565", "reactome": "R-XTR-9027321", "name": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9027049" ], "products": [ "species_29356", "species_29366", "species_9027324" ], "modifiers": [ [ "species_10312165", "catalyst" ] ], "additional_components": [ "CHEBI:137368", "CHEBI:137361", "ENSXETG00000033706" ] }, "reaction_10337560": { "compartment": "compartment_70101", "id": "reaction_10337560", "reactome": "R-XTR-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9024011" ], "products": [ "species_29356", "species_29366", "species_9027049" ], "modifiers": [ [ "species_10337557", "catalyst" ] ], "additional_components": [ "A4IGV4", "ENSXETT00000061279", "A0A6I8PUP3", "ENSXETG00000033706", "F7B981", "ENSXETT00000026362", "A0A6I8Q6H5", "ENSXETT00000026362" ] }, "reaction_10337563": { "compartment": "compartment_70101", "id": "reaction_10337563", "reactome": "R-XTR-9027302", "name": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9027029", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_9027326", "species_29366" ], "modifiers": [ [ "species_10312165", "catalyst" ] ], "additional_components": [ "CHEBI:137360", "CHEBI:137354", "ENSXETG00000033706" ] }, "reaction_10337696": { "compartment": "compartment_12045", "id": "reaction_10337696", "reactome": "R-XTR-9037761", "name": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024886", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_9037755" ], "modifiers": [ [ "species_10312224", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10337555": { "compartment": "compartment_70101", "id": "reaction_10337555", "reactome": "R-XTR-9026911", "name": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024768" ], "products": [ "species_9026915" ], "modifiers": [ [ "species_10337550", "catalyst" ] ], "additional_components": [ "A0A6I8QSM3", "ENSXETG00000036146" ] }, "reaction_10337553": { "compartment": "compartment_70101", "id": "reaction_10337553", "reactome": "R-XTR-9026780", "name": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9025001" ], "products": [ "species_9026761" ], "modifiers": [ [ "species_10337550", "catalyst" ] ], "additional_components": [ "A0A6I8QSM3", "ENSXETG00000036146" ] }, "reaction_10337567": { "compartment": "compartment_70101", "id": "reaction_10337567", "reactome": "R-XTR-9027624", "name": "ALOX5 oxidises DHA to 7-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024011" ], "products": [ "species_9028274" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337569": { "compartment": "compartment_70101", "id": "reaction_10337569", "reactome": "R-XTR-9027628", "name": "ALOX5 oxidises EPA to 5-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2026977", "species_29368" ], "products": [ "species_9028283" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337571": { "compartment": "compartment_70101", "id": "reaction_10337571", "reactome": "R-XTR-9027633", "name": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9608444", "species_29368" ], "products": [ "species_9028240" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337542": { "compartment": "compartment_70101", "id": "reaction_10337542", "reactome": "R-XTR-9026005", "name": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026293", "species_29368" ], "products": [ "species_9026311" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337544": { "compartment": "compartment_70101", "id": "reaction_10337544", "reactome": "R-XTR-9026405", "name": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026400", "species_29368" ], "products": [ "species_9026394" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "CHEBI:137020", "CHEBI:137011", "CHEBI:137018", "CHEBI:137019", "ENSXETG00000007490" ] }, "reaction_10337540": { "compartment": "compartment_70101", "id": "reaction_10337540", "reactome": "R-XTR-9025999", "name": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9026047" ], "products": [ "species_9026046", "species_29364" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337536": { "compartment": "compartment_70101", "id": "reaction_10337536", "reactome": "R-XTR-9025995", "name": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026034", "species_29366" ], "products": [ "species_9026050", "species_29364" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337538": { "compartment": "compartment_70101", "id": "reaction_10337538", "reactome": "R-XTR-9025996", "name": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9026047" ], "products": [ "species_9026034" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337481": { "compartment": "compartment_70101", "id": "reaction_10337481", "reactome": "R-XTR-9018863", "name": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023651", "species_29368" ], "products": [ "species_9023702" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337483": { "compartment": "compartment_70101", "id": "reaction_10337483", "reactome": "R-XTR-9018894", "name": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023702", "species_29368" ], "products": [ "species_9023708" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337477": { "compartment": "compartment_70101", "id": "reaction_10337477", "reactome": "R-XTR-9018858", "name": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9020474" ], "products": [ "species_9020602" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337479": { "compartment": "compartment_70101", "id": "reaction_10337479", "reactome": "R-XTR-9018859", "name": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9020602" ], "products": [ "species_9022655" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10312123": { "compartment": "compartment_70101", "id": "reaction_10312123", "reactome": "R-XTR-75883", "name": "DHRS7B reduces GO3P to HXDG3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75973", "species_29364" ], "products": [ "species_29366", "species_390422" ], "modifiers": [ [ "species_10312120", "catalyst" ] ], "additional_components": [ "ENSXETT00000013330" ] }, "reaction_10334716": { "compartment": "compartment_12045", "id": "reaction_10334716", "reactome": "R-XTR-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200993", "species_30209" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10331494", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10334713": { "compartment": "compartment_12045", "id": "reaction_10334713", "reactome": "R-XTR-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_8848499", "species_76194" ], "modifiers": [ [ "species_10331494", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10326149": { "compartment": "compartment_70101", "id": "reaction_10326149", "reactome": "R-XTR-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_2162081", "species_73473" ], "modifiers": [ [ "species_10311790", "catalyst" ] ], "additional_components": [ "A0A6I8RYK1", "ENSXETG00000032351", "species_29426" ] }, "reaction_10326146": { "compartment": "compartment_70101", "id": "reaction_10326146", "reactome": "R-XTR-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10312008", "catalyst" ] ], "additional_components": [ "species_109496", "Q5EBF1", "ENSXETG00000009475" ] }, "reaction_10324293": { "compartment": "compartment_876", "id": "reaction_10324293", "reactome": "R-XTR-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10324290", "catalyst" ] ], "additional_components": [ "species_74112", "A0A6I8QLK5", "ENSXETG00000030514", "A0A6I8SLR0", "ENSXETG00000003578", "A0A6I8QCS0", "ENSXETG00000007772" ] }, "reaction_10324274": { "compartment": "compartment_70101", "id": "reaction_10324274", "reactome": "R-XTR-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10324015", "catalyst" ] ], "additional_components": [ "ENSXETG00000009899" ] }, "reaction_10324265": { "compartment": "compartment_70101", "id": "reaction_10324265", "reactome": "R-XTR-1855202", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629746" ], "products": [ "species_29372", "species_1629731" ], "modifiers": [ [ "species_10324057", "catalyst" ] ], "additional_components": [ "ENSXETG00000019407" ] }, "reaction_10324246": { "compartment": "compartment_70101", "id": "reaction_10324246", "reactome": "R-XTR-1855180", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994123" ], "products": [ "species_29372", "species_1629769" ], "modifiers": [ [ "species_10324057", "catalyst" ] ], "additional_components": [ "ENSXETG00000019407" ] }, "reaction_10324243": { "compartment": "compartment_70101", "id": "reaction_10324243", "reactome": "R-XTR-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10324015", "catalyst" ] ], "additional_components": [ "ENSXETG00000009899" ] }, "reaction_10324268": { "compartment": "compartment_7660", "id": "reaction_10324268", "reactome": "R-XTR-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10324230", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324249": { "compartment": "compartment_7660", "id": "reaction_10324249", "reactome": "R-XTR-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10324230", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324233": { "compartment": "compartment_7660", "id": "reaction_10324233", "reactome": "R-XTR-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10324230", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324299": { "compartment": "compartment_7660", "id": "reaction_10324299", "reactome": "R-XTR-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023940" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10324230", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324305": { "compartment": "compartment_7660", "id": "reaction_10324305", "reactome": "R-XTR-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023922" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10324230", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10323209": { "compartment": "compartment_876", "id": "reaction_10323209", "reactome": "R-XTR-1475017", "name": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10322211", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8QID1", "ENSXETG00000034545" ] }, "reaction_10323220": { "compartment": "compartment_876", "id": "reaction_10323220", "reactome": "R-XTR-1475025", "name": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10322211", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8QID1", "ENSXETG00000034545" ] }, "reaction_10323222": { "compartment": "compartment_70101", "id": "reaction_10323222", "reactome": "R-XTR-1475026", "name": "Carbonic anhydrase hydrates carbon dioxide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113528" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10323215", "catalyst" ] ], "additional_components": [ "Q28CD7", "ENSXETT00000069496", "species_29426" ] }, "reaction_10323218": { "compartment": "compartment_70101", "id": "reaction_10323218", "reactome": "R-XTR-1475022", "name": "Carbonic anhydrase dehydrates bicarbonate (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_29356", "species_113528" ], "modifiers": [ [ "species_10323215", "catalyst" ] ], "additional_components": [ "Q28CD7", "ENSXETT00000069496", "species_29426" ] }, "reaction_10331322": { "compartment": "compartment_17963", "id": "reaction_10331322", "reactome": "R-XTR-5693925", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693930", "species_205683" ], "products": [ "species_5693933", "species_205689" ], "modifiers": [ [ "species_10331319", "catalyst" ] ], "additional_components": [ "ENSXETG00000032714" ] }, "reaction_10321826": { "compartment": "compartment_20699", "id": "reaction_10321826", "reactome": "R-XTR-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10321823", "catalyst" ] ], "additional_components": [ "ENSXETT00000016641" ] }, "reaction_10318217": { "compartment": "compartment_1462052", "id": "reaction_10318217", "reactome": "R-XTR-437085", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10318214", "catalyst" ] ], "additional_components": [ "ENSXETG00000000472" ] }, "reaction_10318231": { "compartment": "compartment_20699", "id": "reaction_10318231", "reactome": "R-XTR-437139", "name": "ZnT6 transports zinc into the golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216667" ], "modifiers": [ [ "species_10318228", "catalyst" ] ], "additional_components": [ "ENSXETT00000054089" ] }, "reaction_10318224": { "compartment": "compartment_20699", "id": "reaction_10318224", "reactome": "R-XTR-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10318221", "catalyst" ] ], "additional_components": [ "ENSXETG00000027945" ] }, "reaction_10318210": { "compartment": "compartment_876", "id": "reaction_10318210", "reactome": "R-XTR-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10318207", "catalyst" ] ], "additional_components": [ "ENSXETG00000034450" ] }, "reaction_10336888": { "compartment": "compartment_70101", "id": "reaction_10336888", "reactome": "R-XTR-8952716", "name": "SLC38A9 binds Ragulator:Rag dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330239", "species_10330253" ], "products": [ "species_10330255" ], "modifiers": [], "additional_components": [ "ENSXETG00000028090", "F6W400", "ENSXETT00000041436", "species_29438", "B4F6Y3", "ENSXETG00000026765", "Q6DF40", "ENSXETG00000020403", "A9UL91", "ENSXETT00000103950", "Q6P2W7", "ENSXETG00000024963", "F6W400", "ENSXETT00000041436", "species_29438", "B4F6Y3", "ENSXETG00000026765", "Q6DF40", "ENSXETG00000020403", "A9UL91", "ENSXETT00000103950", "Q6P2W7", "ENSXETG00000024963", "A0A6I8RIW4", "ENSXETG00000028090" ] }, "reaction_10336891": { "compartment": "compartment_70101", "id": "reaction_10336891", "reactome": "R-XTR-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10330255", "catalyst" ] ], "additional_components": [ "F6W400", "ENSXETT00000041436", "species_29438", "B4F6Y3", "ENSXETG00000026765", "Q6DF40", "ENSXETG00000020403", "A9UL91", "ENSXETT00000103950", "Q6P2W7", "ENSXETG00000024963", "A0A6I8RIW4", "ENSXETG00000028090" ] }, "reaction_10338102": { "compartment": "compartment_70101", "id": "reaction_10338102", "reactome": "R-XTR-9679044", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338098", "species_9678687" ], "products": [ "species_10338100" ], "modifiers": [], "additional_components": [ "ENSXETT00000003463", "F7BKJ1", "ENSXETT00000003463" ] }, "reaction_10338253": { "compartment": "compartment_984", "id": "reaction_10338253", "reactome": "R-XTR-9707586", "name": "FeHM oxidises LDL,HDL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338243", "species_917955" ], "products": [ "species_917877", "species_10338251" ], "modifiers": [], "additional_components": [ "species_171126", "A0A6I8RKY6", "ENSXETG00000026768", "species_163579", "species_171142", "species_216762", "species_171126", "A0A6I8RKY6", "ENSXETG00000026768", "species_163579", "species_2186967", "species_171142", "species_216762" ] }, "reaction_10338255": { "compartment": "compartment_7660", "id": "reaction_10338255", "reactome": "R-XTR-9707690", "name": "BACH1 binds MAFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321780", "species_10338235" ], "products": [ "species_10338237" ], "modifiers": [], "additional_components": [ "ENSXETT00000041786", "ENSXETT00000017505", "F6Y302", "ENSXETT00000017505", "F7A9R6", "ENSXETT00000041786" ] }, "reaction_10338231": { "compartment": "compartment_984", "id": "reaction_10338231", "reactome": "R-XTR-9707516", "name": "FeHM dissociates from MetHb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326232" ], "products": [ "species_917955", "species_10338229" ], "modifiers": [], "additional_components": [ "P07428", "ENSXETT00000002494", "species_917955", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "P07428", "ENSXETT00000002494", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627" ] }, "reaction_10338241": { "compartment": "compartment_7660", "id": "reaction_10338241", "reactome": "R-XTR-9707523", "name": "Hemes bind to BACH1:MAFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707575", "species_10338237" ], "products": [ "species_10321780", "species_10338239" ], "modifiers": [], "additional_components": [ "F6Y302", "ENSXETT00000017505", "F7A9R6", "ENSXETT00000041786", "ENSXETT00000041786", "F6Y302", "ENSXETT00000017505" ] }, "reaction_10338226": { "compartment": "compartment_984", "id": "reaction_10338226", "reactome": "R-XTR-9707504", "name": "H2O2 oxidises ferrohemoglobin to MetHb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_10338222" ], "products": [ "species_9707624", "species_9707647", "species_10326232" ], "modifiers": [ [ "species_10338224", "inhibitor" ] ], "additional_components": [ "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494", "P07428", "ENSXETT00000002494", "species_917955", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_9709335", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494" ] }, "reaction_10327581": { "compartment": "compartment_70101", "id": "reaction_10327581", "reactome": "R-XTR-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29368", "species_29408" ], "modifiers": [ [ "species_10327578", "catalyst" ] ], "additional_components": [ "species_29426", "species_209799", "Q0IIW3", "ENSXETT00000015994" ] }, "reaction_10331455": { "compartment": "compartment_5460", "id": "reaction_10331455", "reactome": "R-XTR-5696197", "name": "NUDT2 hydrolyses GP4G to GTP, GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696199", "species_113521" ], "products": [ "species_5696194", "species_113573" ], "modifiers": [ [ "species_10331452", "catalyst" ] ], "additional_components": [ "ENSXETT00000004614" ] }, "reaction_10327705": { "compartment": "compartment_70616", "id": "reaction_10327705", "reactome": "R-XTR-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_10313148" ], "products": [ "species_189461", "species_10313146" ], "modifiers": [], "additional_components": [ "Q640U4", "ENSXETT00000018532", "Q6PBF4", "ENSXETT00000049267", "CHEBI:38574", "Q640U4", "ENSXETT00000018532", "Q6PBF4", "ENSXETT00000049267", "CHEBI:38573" ] }, "reaction_10328075": { "compartment": "compartment_5460", "id": "reaction_10328075", "reactome": "R-XTR-3697894", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327691", "species_3697881" ], "products": [ "species_3697842", "species_10327694", "species_113521" ], "modifiers": [ [ "species_10327698", "catalyst" ] ], "additional_components": [ "ENSXETT00000089705", "ENSXETT00000089705", "ENSXETT00000013225" ] }, "reaction_10328149": { "compartment": "compartment_17927", "id": "reaction_10328149", "reactome": "R-XTR-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10328146", "catalyst" ] ], "additional_components": [ "species_209799", "Q0IIW3", "ENSXETT00000015994", "species_29426" ] }, "reaction_10327701": { "compartment": "compartment_5460", "id": "reaction_10327701", "reactome": "R-XTR-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327691", "species_1614617" ], "products": [ "species_10327694", "species_113521" ], "modifiers": [ [ "species_10327698", "catalyst" ] ], "additional_components": [ "ENSXETT00000089705", "ENSXETT00000089705", "ENSXETT00000013225" ] }, "reaction_10327715": { "compartment": "compartment_984", "id": "reaction_10327715", "reactome": "R-XTR-3341397", "name": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_1247892" ], "products": [ "species_109276", "species_3341331" ], "modifiers": [ [ "species_10327712", "catalyst" ] ], "additional_components": [ "Q6P8G5", "ENSXETT00000098364" ] }, "reaction_10333618": { "compartment": "compartment_984", "id": "reaction_10333618", "reactome": "R-XTR-6799695", "name": "GPX5,6 reduce H2O2 to H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_1247892" ], "products": [ "species_109276", "species_3341331" ], "modifiers": [ [ "species_10333613", "catalyst" ] ], "additional_components": [ "ENSXETT00000098364" ] }, "reaction_10338265": { "compartment": "compartment_984", "id": "reaction_10338265", "reactome": "R-XTR-9709317", "name": "CO binds to free ferrohemoglobin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338222", "species_9709335" ], "products": [ "species_10338224" ], "modifiers": [], "additional_components": [ "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494", "species_9709335", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494" ] }, "reaction_10338267": { "compartment": "compartment_984", "id": "reaction_10338267", "reactome": "R-XTR-9709360", "name": "H2O2 reduces MetHb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_10326232" ], "products": [ "species_109276", "species_10338222", "species_352327" ], "modifiers": [], "additional_components": [ "P07428", "ENSXETT00000002494", "species_917955", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494" ] }, "reaction_10338261": { "compartment": "compartment_70101", "id": "reaction_10338261", "reactome": "R-XTR-9708466", "name": "BACH1 translocates from the nucleoplasm to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338235" ], "products": [ "species_10338259" ], "modifiers": [ [ "species_3785707", "catalyst" ] ], "additional_components": [ "ENSXETT00000017505", "ENSXETT00000017505" ] }, "reaction_10321885": { "compartment": "compartment_70101", "id": "reaction_10321885", "reactome": "R-XTR-1234161", "name": "HIF-alpha translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321881" ], "products": [ "species_10321883" ], "modifiers": [], "additional_components": [ "ENSXETG00000026167", "ENSXETG00000026167" ] }, "reaction_10328289": { "compartment": "compartment_7660", "id": "reaction_10328289", "reactome": "R-XTR-3857336", "name": "CEBPB homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328281" ], "products": [ "species_10328283" ], "modifiers": [], "additional_components": [ "ENSXETT00000085676", "Q3SYP1", "ENSXETT00000085676" ] }, "reaction_10327348": { "compartment": "compartment_7660", "id": "reaction_10327348", "reactome": "R-XTR-3240295", "name": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10327345" ], "products": [ "species_77502", "species_10327343" ], "modifiers": [ [ "species_10316473", "catalyst" ] ], "additional_components": [ "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146" ] }, "reaction_10327310": { "compartment": "compartment_7660", "id": "reaction_10327310", "reactome": "R-XTR-3209159", "name": "Phosphorylated ERF translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327306" ], "products": [ "species_10327308" ], "modifiers": [], "additional_components": [ "ENSXETG00000012067", "ENSXETG00000012067" ] }, "reaction_10312580": { "compartment": "compartment_876", "id": "reaction_10312580", "reactome": "R-XTR-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10312577", "catalyst" ] ], "additional_components": [ "L7N333", "ENSXETT00000019255", "F6WUY6", "ENSXETT00000027105", "species_109496" ] }, "reaction_10312589": { "compartment": "compartment_70101", "id": "reaction_10312589", "reactome": "R-XTR-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10312586", "catalyst" ] ], "additional_components": [ "F6YP15", "ENSXETT00000040456" ] }, "reaction_10312591": { "compartment": "compartment_70101", "id": "reaction_10312591", "reactome": "R-XTR-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312586" ], "products": [ "species_10312586" ], "modifiers": [], "additional_components": [ "F6YP15", "ENSXETT00000040456", "F6YP15", "ENSXETT00000040456" ] }, "reaction_10335005": { "compartment": "compartment_17963", "id": "reaction_10335005", "reactome": "R-XTR-8851619", "name": "GALNT3 transfers GalNAc to FGF23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10335000" ], "products": [ "species_10335002", "species_205687" ], "modifiers": [ [ "species_10320310", "catalyst" ] ], "additional_components": [ "ENSXETG00000026353", "ENSXETG00000026353", "ENSXETT00000045011" ] }, "reaction_10335007": { "compartment": "compartment_17963", "id": "reaction_10335007", "reactome": "R-XTR-8851632", "name": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335002" ], "products": [ "species_10314114" ], "modifiers": [], "additional_components": [ "ENSXETG00000026353", "ENSXETG00000026353" ] }, "reaction_10320127": { "compartment": "compartment_876", "id": "reaction_10320127", "reactome": "R-XTR-877187", "name": "P2X7 mediates loss of intracellular K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10320124", "catalyst" ] ], "additional_components": [ "A0A6I8S619", "ENSXETG00000041261", "species_113593" ] }, "reaction_10320159": { "compartment": "compartment_70101", "id": "reaction_10320159", "reactome": "R-XTR-879221", "name": "PSTPIP1 binds Pyrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320155", "species_10320139" ], "products": [ "species_10320157" ], "modifiers": [], "additional_components": [ "A0A6I8QK31", "ENSXETG00000033202", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8QK31", "ENSXETG00000033202", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292" ] }, "reaction_10320120": { "compartment": "compartment_70101", "id": "reaction_10320120", "reactome": "R-XTR-844447", "name": "NLRP1 senses MDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_708341", "species_10320110" ], "products": [ "species_10320112" ], "modifiers": [], "additional_components": [ "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "species_708341" ] }, "reaction_10320149": { "compartment": "compartment_70101", "id": "reaction_10320149", "reactome": "R-XTR-879201", "name": "Bcl-2 and Bcl-XL bind NLRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320145", "species_10320110" ], "products": [ "species_10320147" ], "modifiers": [], "additional_components": [ "A0A6I8QYM7", "ENSXETG00000035771", "F6XC18", "ENSXETT00000050759", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "A0A6I8QYM7", "ENSXETG00000035771", "F6XC18", "ENSXETT00000050759" ] }, "reaction_10320118": { "compartment": "compartment_70101", "id": "reaction_10320118", "reactome": "R-XTR-844438", "name": "NLRP1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320114" ], "products": [ "species_10320116" ], "modifiers": [], "additional_components": [ "species_113593", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "species_708341", "species_113593", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "species_708341" ] }, "reaction_10320161": { "compartment": "compartment_70101", "id": "reaction_10320161", "reactome": "R-XTR-879222", "name": "MDP:NLRP1 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320112", "species_113592" ], "products": [ "species_10320114" ], "modifiers": [], "additional_components": [ "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "species_708341", "species_113593", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "species_708341" ] }, "reaction_10320168": { "compartment": "compartment_876", "id": "reaction_10320168", "reactome": "R-XTR-879585", "name": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879559" ], "products": [ "species_879544" ], "modifiers": [ [ "species_10320165", "catalyst" ] ], "additional_components": [ "CHEBI:16196", "CHEBI:16196", "ENSXETG00000037018" ] }, "reaction_10322403": { "compartment": "compartment_876", "id": "reaction_10322403", "reactome": "R-XTR-1299304", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10322400", "catalyst" ] ], "additional_components": [ "F7AEN8", "ENSXETT00000009094" ] }, "reaction_10322456": { "compartment": "compartment_984", "id": "reaction_10322456", "reactome": "R-XTR-1362465", "name": "GHBP binds GHR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320900", "species_10320910" ], "products": [ "species_10320912" ], "modifiers": [], "additional_components": [ "ENSXETG00000037965", "ENSXETG00000037965", "A0A6I8PXI3", "ENSXETG00000037965" ] }, "reaction_10320917": { "compartment": "compartment_70101", "id": "reaction_10320917", "reactome": "R-XTR-982792", "name": "Growth hormone receptor binds JAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320900", "species_10320904" ], "products": [ "species_10320906" ], "modifiers": [], "additional_components": [ "ENSXETG00000037965", "ENSXETG00000000586", "A0A6I8QZL9", "ENSXETG00000000586", "A0A6I8PXI3", "ENSXETG00000037965" ] }, "reaction_10320914": { "compartment": "compartment_876", "id": "reaction_10320914", "reactome": "R-XTR-982775", "name": "Growth hormone receptor dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320906" ], "products": [ "species_10320908" ], "modifiers": [ [ "species_10320912", "inhibitor" ] ], "additional_components": [ "A0A6I8QZL9", "ENSXETG00000000586", "A0A6I8PXI3", "ENSXETG00000037965", "A0A6I8QZL9", "ENSXETG00000000586", "A0A6I8PXI3", "ENSXETG00000037965", "A0A6I8PXI3", "ENSXETG00000037965" ] }, "reaction_10330559": { "compartment": "compartment_876", "id": "reaction_10330559", "reactome": "R-XTR-5676592", "name": "2xRANK binds RANKL,sRANKL trimer:RANK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330551", "species_10330553" ], "products": [ "species_10330557" ], "modifiers": [], "additional_components": [ "ENSXETT00000001109", "F7DPT4", "ENSXETT00000001109", "F6WJ69", "ENSXETT00000005335", "A0A6I8PXA6", "ENSXETG00000030595", "F7DPT4", "ENSXETT00000001109", "F6WJ69", "ENSXETT00000005335", "A0A6I8PXA6", "ENSXETG00000030595" ] }, "reaction_10330555": { "compartment": "compartment_876", "id": "reaction_10330555", "reactome": "R-XTR-5676589", "name": "RANKL,sRANKL trimer binds RANK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330455", "species_10330551" ], "products": [ "species_10330553" ], "modifiers": [], "additional_components": [ "F6WJ69", "ENSXETT00000005335", "A0A6I8PXA6", "ENSXETG00000030595", "ENSXETT00000001109", "F7DPT4", "ENSXETT00000001109", "F6WJ69", "ENSXETT00000005335", "A0A6I8PXA6", "ENSXETG00000030595" ] }, "reaction_10330429": { "compartment": "compartment_876", "id": "reaction_10330429", "reactome": "R-XTR-5669012", "name": "EDA binds EDAR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330421", "species_10330425" ], "products": [ "species_10330427" ], "modifiers": [], "additional_components": [ "ENSXETG00000039649", "ENSXETT00000004819", "Q6DF68", "ENSXETT00000004819", "A0A6I8RPF6", "ENSXETG00000039649" ] }, "reaction_10330437": { "compartment": "compartment_876", "id": "reaction_10330437", "reactome": "R-XTR-5669013", "name": "EDA-3 binds EDA2R", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330433", "species_10330421" ], "products": [ "species_10330435" ], "modifiers": [], "additional_components": [ "ENSXETT00000025196", "ENSXETG00000039649", "A0A6I8RPF6", "ENSXETG00000039649", "F7D7R4", "ENSXETT00000025196" ] }, "reaction_10330465": { "compartment": "compartment_876", "id": "reaction_10330465", "reactome": "R-XTR-5669097", "name": "LTA trimer binds TNFRSF1A,1B,14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330459", "species_10330461" ], "products": [ "species_10330463" ], "modifiers": [], "additional_components": [ "A0A6I8PXQ3", "ENSXETG00000035588", "A0A6I8PW21", "ENSXETG00000032118", "A0A6I8PXQ3", "ENSXETG00000035588", "A0A6I8PW21", "ENSXETG00000032118" ] }, "reaction_10332225": { "compartment": "compartment_984", "id": "reaction_10332225", "reactome": "R-XTR-6783670", "name": "CRLF1 binds CLCF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331527", "species_10331531" ], "products": [ "species_10331533" ], "modifiers": [], "additional_components": [ "F6UWV2", "ENSXETT00000045077", "A0A6I8SGV0", "ENSXETG00000036989", "ENSXETG00000023198", "A0A6I8PWA6", "ENSXETG00000023198", "F6UWV2", "ENSXETT00000045077", "A0A6I8SGV0", "ENSXETG00000036989" ] }, "reaction_10337128": { "compartment": "compartment_70101", "id": "reaction_10337128", "reactome": "R-XTR-9008684", "name": "TBK1 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10320676" ], "products": [ "species_10337126", "species_29370" ], "modifiers": [], "additional_components": [ "ENSXETG00000007322", "ENSXETG00000007322" ] }, "reaction_10327030": { "compartment": "compartment_70101", "id": "reaction_10327030", "reactome": "R-XTR-2730894", "name": "NFKB1:RELA translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313343" ], "products": [ "species_10313349" ], "modifiers": [], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173" ] }, "reaction_10332406": { "compartment": "compartment_17957", "id": "reaction_10332406", "reactome": "R-XTR-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10332404" ], "modifiers": [], "additional_components": [ "ENSXETG00000005359" ] }, "reaction_10332274": { "compartment": "compartment_70101", "id": "reaction_10332274", "reactome": "R-XTR-6785898", "name": "IL4R binds JAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320904", "species_10332270" ], "products": [ "species_10332272" ], "modifiers": [], "additional_components": [ "ENSXETG00000000586", "ENSXETG00000040733", "A0A6I8S2C9", "ENSXETG00000040733", "A0A6I8QZL9", "ENSXETG00000000586" ] }, "reaction_10318525": { "compartment": "compartment_984", "id": "reaction_10318525", "reactome": "R-XTR-448632", "name": "IL34 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318521" ], "products": [ "species_10318523" ], "modifiers": [], "additional_components": [ "ENSXETG00000038235", "A0A6I8QP85", "ENSXETG00000038235" ] }, "reaction_10318556": { "compartment": "compartment_984", "id": "reaction_10318556", "reactome": "R-XTR-449087", "name": "CD4 binds Interleukin-16", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318546", "species_10318552" ], "products": [ "species_10318554" ], "modifiers": [], "additional_components": [ "ENSXETG00000031478", "ENSXETT00000017485", "F7BD23", "ENSXETT00000017485", "A0A6I8SKD0", "ENSXETG00000031478" ] }, "reaction_10337036": { "compartment": "compartment_984", "id": "reaction_10337036", "reactome": "R-XTR-8981657", "name": "IL34 dimer binds PTPRZ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318523", "species_10337032" ], "products": [ "species_10337034" ], "modifiers": [], "additional_components": [ "A0A6I8QP85", "ENSXETG00000038235", "ENSXETG00000022735", "A0A6I8QZW2", "ENSXETG00000022735", "A0A6I8QP85", "ENSXETG00000038235" ] }, "reaction_10318548": { "compartment": "compartment_984", "id": "reaction_10318548", "reactome": "R-XTR-449077", "name": "Interleukin-16 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318541" ], "products": [ "species_10318546" ], "modifiers": [], "additional_components": [ "ENSXETG00000031478", "ENSXETG00000031478" ] }, "reaction_10318544": { "compartment": "compartment_70101", "id": "reaction_10318544", "reactome": "R-XTR-449073", "name": "Caspase-3 cleaves pro-interleukin-16", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318537" ], "products": [ "species_10318539", "species_10318541" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000031478", "ENSXETG00000031478", "ENSXETG00000031478", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10324152": { "compartment": "compartment_70101", "id": "reaction_10324152", "reactome": "R-XTR-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324128", "species_10324148" ], "products": [ "species_10324146", "species_10324150" ], "modifiers": [], "additional_components": [ "A0A6I8S9G6", "ENSXETG00000036095", "A0A6I8QSS2", "ENSXETG00000027885", "A0A6I8SXK0", "ENSXETG00000017287", "Q28ET8", "ENSXETG00000015908", "B7ZTW1", "ENSXETT00000030049", "F6V5S1", "ENSXETT00000039793", "A0A6I8SXK0", "ENSXETG00000017287", "Q28ET8", "ENSXETG00000015908", "B7ZTW1", "ENSXETT00000030049", "F6V5S1", "ENSXETT00000039793", "A0A6I8S9G6", "ENSXETG00000036095", "A0A6I8QSS2", "ENSXETG00000027885" ] }, "reaction_10320256": { "compartment": "compartment_70101", "id": "reaction_10320256", "reactome": "R-XTR-912685", "name": "UBP43 binds IFNAR2 and prevents JAK1 interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320248", "species_10320252" ], "products": [ "species_10320254" ], "modifiers": [], "additional_components": [ "ENSXETG00000038384", "ENSXETG00000034297", "A0A6I8R9K6", "ENSXETG00000034297", "A0A6I8QPM9", "ENSXETG00000038384" ] }, "reaction_10338086": { "compartment": "compartment_70101", "id": "reaction_10338086", "reactome": "R-XTR-9678561", "name": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338082", "species_9678984" ], "products": [ "species_10338084" ], "modifiers": [], "additional_components": [ "A0A6I8QPM9", "ENSXETG00000038384", "A0A6I8PL76", "ENSXETG00000030084", "A0A6I8QZL9", "ENSXETG00000000586", "A0A6I8QPM9", "ENSXETG00000038384", "A0A6I8PL76", "ENSXETG00000030084", "A0A6I8QZL9", "ENSXETG00000000586" ] }, "reaction_10315732": { "compartment": "compartment_70101", "id": "reaction_10315732", "reactome": "R-XTR-202407", "name": "PLC-gamma1 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10315729", "catalyst" ] ], "additional_components": [ "ENSXETG00000003578" ] }, "reaction_10317382": { "compartment": "compartment_70101", "id": "reaction_10317382", "reactome": "R-XTR-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317378", "species_10312717" ], "products": [ "species_10317376", "species_10317380" ], "modifiers": [], "additional_components": [ "A0A6I8T271", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10317356": { "compartment": "compartment_876", "id": "reaction_10317356", "reactome": "R-XTR-389523", "name": "BTLA interacts with HVEM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317348", "species_10317352" ], "products": [ "species_10317354" ], "modifiers": [], "additional_components": [ "ENSXETG00000040606", "ENSXETG00000035588", "A0A6I8PXQ3", "ENSXETG00000035588", "A0A6I8QYL7", "ENSXETG00000040606" ] }, "reaction_10317402": { "compartment": "compartment_70101", "id": "reaction_10317402", "reactome": "R-XTR-389919", "name": "Grb2 binds pBTLA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317398", "species_10312043" ], "products": [ "species_10317400" ], "modifiers": [], "additional_components": [ "A0A6I8PXQ3", "ENSXETG00000035588", "A0A6I8QYL7", "ENSXETG00000040606", "ENSXETT00000027387", "Q66II3", "ENSXETT00000027387", "A0A6I8PXQ3", "ENSXETG00000035588", "A0A6I8QYL7", "ENSXETG00000040606" ] }, "reaction_10338149": { "compartment": "compartment_70101", "id": "reaction_10338149", "reactome": "R-XTR-9690461", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338098", "species_9678991" ], "products": [ "species_10338147" ], "modifiers": [], "additional_components": [ "ENSXETT00000003463", "F7BKJ1", "ENSXETT00000003463" ] }, "reaction_10321852": { "compartment": "compartment_70101", "id": "reaction_10321852", "reactome": "R-XTR-1168633", "name": "NF-kappaB translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321840" ], "products": [ "species_10321850" ], "modifiers": [], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SJP9", "ENSXETG00000002209", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SJP9", "ENSXETG00000002209" ] }, "reaction_10321828": { "compartment": "compartment_70101", "id": "reaction_10321828", "reactome": "R-XTR-1168373", "name": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_10312735", "species_74016" ], "products": [ "species_10312741" ], "modifiers": [], "additional_components": [ "ENSXETG00000017294", "species_114519", "species_33625", "species_74112", "A8KBH6", "ENSXETG00000017294" ] }, "reaction_10316771": { "compartment": "compartment_70101", "id": "reaction_10316771", "reactome": "R-XTR-354173", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10316762" ], "products": [ "species_29420", "species_10316760" ], "modifiers": [ [ "species_10316768", "catalyst" ] ], "additional_components": [ "Q640R7", "ENSXETT00000104159", "species_29420", "Q640R7", "ENSXETT00000104159", "species_29438", "species_74112", "A0A6I8S7H2", "ENSXETG00000040253", "species_114519" ] }, "reaction_10317651": { "compartment": "compartment_70101", "id": "reaction_10317651", "reactome": "R-XTR-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316760" ], "products": [ "species_111294", "species_10316762" ], "modifiers": [ [ "species_10317648", "catalyst" ] ], "additional_components": [ "Q640R7", "ENSXETT00000104159", "species_29438", "Q640R7", "ENSXETT00000104159", "species_29420", "ENSXETG00000034215" ] }, "reaction_10335085": { "compartment": "compartment_876", "id": "reaction_10335085", "reactome": "R-XTR-8852010", "name": "BTNL2 binds activated T cells surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851965", "species_10335081" ], "products": [ "species_10335083" ], "modifiers": [], "additional_components": [ "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889" ] }, "reaction_10334889": { "compartment": "compartment_876", "id": "reaction_10334889", "reactome": "R-XTR-8851018", "name": "BTN2A1 binds DC-SIGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334885", "species_10329899" ], "products": [ "species_10334887" ], "modifiers": [], "additional_components": [ "A0A6I8RCC8", "ENSXETT00000021506", "F7AL17", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8SQD0", "ENSXETG00000030055", "K9J7V7", "ENSXETT00000021506", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "A0A6I8RCC8", "ENSXETT00000021506", "F7AL17", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8SQD0", "ENSXETG00000030055", "K9J7V7", "ENSXETT00000021506" ] }, "reaction_10336232": { "compartment": "compartment_876", "id": "reaction_10336232", "reactome": "R-XTR-8938431", "name": "BTN3A1 and BTN1A1 binds periplakin (PPL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336224", "species_10336228" ], "products": [ "species_10336230" ], "modifiers": [], "additional_components": [ "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506", "ENSXETG00000009137", "A0A6I8RD21", "ENSXETG00000009137", "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506" ] }, "reaction_10334949": { "compartment": "compartment_876", "id": "reaction_10334949", "reactome": "R-XTR-8851038", "name": "BTN3A1 binds prenylated phosphoantigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851032", "species_10334945" ], "products": [ "species_10334947" ], "modifiers": [], "additional_components": [ "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055" ] }, "reaction_10335063": { "compartment": "compartment_876", "id": "reaction_10335063", "reactome": "R-XTR-8851988", "name": "BTN2A2 binds T cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335059", "species_8851965" ], "products": [ "species_10335061" ], "modifiers": [], "additional_components": [ "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506" ] }, "reaction_10335041": { "compartment": "compartment_876", "id": "reaction_10335041", "reactome": "R-XTR-8851979", "name": "BTNL9 binds immune cell surfaces", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851998", "species_10335037" ], "products": [ "species_10335039" ], "modifiers": [], "additional_components": [ "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055" ] }, "reaction_10335107": { "compartment": "compartment_876", "id": "reaction_10335107", "reactome": "R-XTR-8852013", "name": "BTNL8 binds resting T cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851976", "species_10335103" ], "products": [ "species_10335105" ], "modifiers": [], "additional_components": [ "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506" ] }, "reaction_10326539": { "compartment": "compartment_453088", "id": "reaction_10326539", "reactome": "R-XTR-2213239", "name": "Formation of MHC II alpha beta heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326535", "species_10326509" ], "products": [ "species_10326537" ], "modifiers": [], "additional_components": [ "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8PRA1", "ENSXETG00000034043" ] }, "reaction_10326006": { "compartment": "compartment_161320", "id": "reaction_10326006", "reactome": "R-XTR-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10326003", "catalyst" ] ], "additional_components": [ "A0A6I8RUR5", "ENSXETG00000035955", "A0A6I8QK05", "ENSXETG00000027581" ] }, "reaction_10335318": { "compartment": "compartment_876", "id": "reaction_10335318", "reactome": "R-XTR-8856157", "name": "LAG3 (CD233) binds MHC II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335314", "species_10335260" ], "products": [ "species_10335316" ], "modifiers": [], "additional_components": [ "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091", "ENSXETG00000004981", "A0A6I8PSX8", "ENSXETG00000004981", "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091" ] }, "reaction_10326627": { "compartment": "compartment_161320", "id": "reaction_10326627", "reactome": "R-XTR-2213244", "name": "Loading of antigenic peptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213226", "species_10326623" ], "products": [ "species_10326625", "species_10326567" ], "modifiers": [], "additional_components": [ "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8PRA1", "ENSXETG00000034043" ] }, "reaction_10321631": { "compartment": "compartment_13945", "id": "reaction_10321631", "reactome": "R-XTR-983421", "name": "Journey of cargo through Golgi complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321513" ], "products": [ "species_10321629" ], "modifiers": [], "additional_components": [ "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "CHEBI:59080", "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "CHEBI:59080" ] }, "reaction_10321747": { "compartment": "compartment_876", "id": "reaction_10321747", "reactome": "R-XTR-983427", "name": "Expression of peptide bound class I MHC on cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321629" ], "products": [ "species_10314568" ], "modifiers": [], "additional_components": [ "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "CHEBI:59080", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246" ] }, "reaction_10322204": { "compartment": "compartment_1222693", "id": "reaction_10322204", "reactome": "R-XTR-1236965", "name": "Export of peptide loaded MHC class I complex to PM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322202" ], "products": [ "species_10314568" ], "modifiers": [], "additional_components": [ "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246" ] }, "reaction_10322086": { "compartment": "compartment_876", "id": "reaction_10322086", "reactome": "R-XTR-1236964", "name": "Translocation of peptide bound MHC class I complex to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322080" ], "products": [ "species_10314568" ], "modifiers": [], "additional_components": [ "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246", "species_1236727", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246" ] }, "reaction_10322082": { "compartment": "compartment_171043", "id": "reaction_10322082", "reactome": "R-XTR-1236943", "name": "Loading of antigen peptide onto MHC class I molecule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236727", "species_10322078" ], "products": [ "species_10322080" ], "modifiers": [], "additional_components": [ "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246", "species_1236727" ] }, "reaction_10321964": { "compartment": "compartment_24339", "id": "reaction_10321964", "reactome": "R-XTR-1236941", "name": "Internalization of receptor bound antigen into clathrin coted vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321942" ], "products": [ "species_10321962" ], "modifiers": [], "additional_components": [ "species_1236715", "L7N3D8", "ENSXETT00000028489", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "species_1236715", "L7N3D8", "ENSXETT00000028489", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813" ] }, "reaction_10322084": { "compartment": "compartment_24339", "id": "reaction_10322084", "reactome": "R-XTR-1236955", "name": "Movement of clathrin coated vesicles into early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321962" ], "products": [ "species_10321920" ], "modifiers": [], "additional_components": [ "species_1236715", "L7N3D8", "ENSXETT00000028489", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "L7N3D8", "ENSXETT00000028489", "species_1236715" ] }, "reaction_10321922": { "compartment": "compartment_171043", "id": "reaction_10321922", "reactome": "R-XTR-1236940", "name": "Exogenous soluble antigen targeted to more stable early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321920" ], "products": [ "species_1236715", "species_10321918" ], "modifiers": [], "additional_components": [ "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "L7N3D8", "ENSXETT00000028489", "species_1236715", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "L7N3D8", "ENSXETT00000028489" ] }, "reaction_10321357": { "compartment": "compartment_70101", "id": "reaction_10321357", "reactome": "R-XTR-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321345", "species_113592", "species_10321339" ], "products": [ "species_111294", "species_10321352", "species_10321337", "species_76577" ], "modifiers": [ [ "species_10321345", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "Q6GL05", "ENSXETT00000101990", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "Q6GL05", "ENSXETT00000101990", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608" ] }, "reaction_10321359": { "compartment": "compartment_70101", "id": "reaction_10321359", "reactome": "R-XTR-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321281", "species_10321339", "species_983035" ], "products": [ "species_10321341" ], "modifiers": [], "additional_components": [ "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "Q6GL05", "ENSXETT00000101990", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q6GL05", "ENSXETT00000101990", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608" ] }, "reaction_10321354": { "compartment": "compartment_70101", "id": "reaction_10321354", "reactome": "R-XTR-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321352" ], "products": [ "species_10321281", "species_983123" ], "modifiers": [], "additional_components": [ "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608" ] }, "reaction_10321348": { "compartment": "compartment_70101", "id": "reaction_10321348", "reactome": "R-XTR-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10321341" ], "products": [ "species_111294", "species_10321345", "species_10321337", "species_76577" ], "modifiers": [ [ "species_10321281", "catalyst" ] ], "additional_components": [ "Q6GL05", "ENSXETT00000101990", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "Q6GL05", "ENSXETT00000101990", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608" ] }, "reaction_10334525": { "compartment": "compartment_984", "id": "reaction_10334525", "reactome": "R-XTR-6807585", "name": "BPI binds LPS on the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10313204" ], "products": [ "species_10334523" ], "modifiers": [], "additional_components": [ "ENSXETG00000017331", "A0A6I8REW5", "ENSXETG00000017331", "species_166005" ] }, "reaction_10333951": { "compartment": "compartment_984", "id": "reaction_10333951", "reactome": "R-XTR-6801762", "name": "REG3A oligomerize to form a pore complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333945" ], "products": [ "species_10333949" ], "modifiers": [ [ "species_166005", "inhibitor" ] ], "additional_components": [ "CHEBI:62643", "A0A6I8PQ14", "ENSXETG00000033383", "CHEBI:62643", "A0A6I8PQ14", "ENSXETG00000033383" ] }, "reaction_10321873": { "compartment": "compartment_1222282", "id": "reaction_10321873", "reactome": "R-XTR-1222491", "name": "Lactoferrin scavenges iron ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2101051", "species_1222611", "species_10321869" ], "products": [ "species_10321871" ], "modifiers": [], "additional_components": [ "ENSXETG00000011814", "Q501K5", "ENSXETG00000011814", "species_912516", "species_2101051" ] }, "reaction_10333978": { "compartment": "compartment_984", "id": "reaction_10333978", "reactome": "R-XTR-6803063", "name": "RNASEs bind bacterial LPS, PGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333974", "species_6803074" ], "products": [ "species_10333976" ], "modifiers": [], "additional_components": [ "A0A6I8R6T7", "ENSXETG00000038487", "CHEBI:55478", "species_6789198", "species_166005", "CHEBI:55478", "species_6789198", "species_166005", "A0A6I8R6T7", "ENSXETG00000038487" ] }, "reaction_10334646": { "compartment": "compartment_984", "id": "reaction_10334646", "reactome": "R-XTR-6813659", "name": "ELANE, CTSG or PRTN3 binds bacteria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334642", "species_8879165" ], "products": [ "species_10334644" ], "modifiers": [], "additional_components": [ "A0A6I8RBC3", "ENSXETG00000037351", "Q5HZU5", "ENSXETT00000093455", "A0A6I8QPJ5", "ENSXETG00000039590", "F7EHU5", "ENSXETT00000037000", "A0A6I8RBC3", "ENSXETG00000037351", "Q5HZU5", "ENSXETT00000093455", "A0A6I8QPJ5", "ENSXETG00000039590", "F7EHU5", "ENSXETT00000037000" ] }, "reaction_10334033": { "compartment": "compartment_984", "id": "reaction_10334033", "reactome": "R-XTR-6804527", "name": "INTL1 binds bacterial glycans", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334029", "species_6804535" ], "products": [ "species_10334031" ], "modifiers": [], "additional_components": [ "species_74112", "F7BS21", "ENSXETT00000047100", "CHEBI:42976", "CHEBI:59496", "CHEBI:85986", "CHEBI:42976", "CHEBI:59496", "CHEBI:85986", "species_74112", "F7BS21", "ENSXETT00000047100" ] }, "reaction_10334640": { "compartment": "compartment_984", "id": "reaction_10334640", "reactome": "R-XTR-6813626", "name": "LEAP2 binds bacteria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334636", "species_8931784" ], "products": [ "species_10334638" ], "modifiers": [], "additional_components": [ "ENSXETG00000030080", "CHEBI:62643", "CHEBI:62643", "A0A6I8QY26", "ENSXETG00000030080" ] }, "reaction_10333966": { "compartment": "compartment_984", "id": "reaction_10333966", "reactome": "R-XTR-6801808", "name": "REG3A,REG3G binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333943", "species_6789198" ], "products": [ "species_10333964" ], "modifiers": [], "additional_components": [ "ENSXETG00000033383", "species_6789198", "A0A6I8PQ14", "ENSXETG00000033383" ] }, "reaction_10333960": { "compartment": "compartment_984", "id": "reaction_10333960", "reactome": "R-XTR-6801766", "name": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333953" ], "products": [ "species_10333955", "species_10333943" ], "modifiers": [ [ "species_10333957", "catalyst" ] ], "additional_components": [ "ENSXETG00000033383", "ENSXETG00000033383", "ENSXETG00000033383", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148" ] }, "reaction_10336840": { "compartment": "compartment_984", "id": "reaction_10336840", "reactome": "R-XTR-8948027", "name": "RNASEs bind bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333974", "species_8931784" ], "products": [ "species_10336838" ], "modifiers": [], "additional_components": [ "A0A6I8R6T7", "ENSXETG00000038487", "CHEBI:62643", "CHEBI:62643", "A0A6I8R6T7", "ENSXETG00000038487" ] }, "reaction_10333962": { "compartment": "compartment_984", "id": "reaction_10333962", "reactome": "R-XTR-6801776", "name": "REG3A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333943", "species_8931784" ], "products": [ "species_10333945" ], "modifiers": [], "additional_components": [ "ENSXETG00000033383", "CHEBI:62643", "CHEBI:62643", "A0A6I8PQ14", "ENSXETG00000033383" ] }, "reaction_10335621": { "compartment": "compartment_984", "id": "reaction_10335621", "reactome": "R-XTR-8862320", "name": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10335616" ], "products": [ "species_6788991", "species_6788982" ], "modifiers": [ [ "species_10335616", "catalyst" ] ], "additional_components": [ "A0A6I8RID5", "ENSXETG00000037293", "species_6789198", "species_1236715", "CHEBI:21615", "A0A6I8RID5", "ENSXETG00000037293", "species_6789198" ] }, "reaction_10334628": { "compartment": "compartment_984", "id": "reaction_10334628", "reactome": "R-XTR-6810724", "name": "PI3 binds the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10334624" ], "products": [ "species_10334626" ], "modifiers": [], "additional_components": [ "A0A6I8RZ58", "ENSXETG00000038864", "A0A6I8QJ14", "ENSXETG00000036342", "A0A6I8RZ58", "ENSXETG00000038864", "A0A6I8QJ14", "ENSXETG00000036342", "species_166005" ] }, "reaction_10333638": { "compartment": "compartment_984", "id": "reaction_10333638", "reactome": "R-XTR-6799959", "name": "PGLYRP3,4 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333634", "species_6789198" ], "products": [ "species_10333636" ], "modifiers": [ [ "species_158417", "catalyst" ] ], "additional_components": [ "Q5BKE6", "ENSXETT00000089406", "species_6789198", "Q5BKE6", "ENSXETT00000089406" ] }, "reaction_10332387": { "compartment": "compartment_1222282", "id": "reaction_10332387", "reactome": "R-XTR-6789072", "name": "PGLYRP1 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10332383" ], "products": [ "species_10332385" ], "modifiers": [ [ "species_1562550", "catalyst" ] ], "additional_components": [ "Q5BKE6", "ENSXETT00000089406", "Q5BKE6", "ENSXETT00000089406", "species_6789198" ] }, "reaction_10335618": { "compartment": "compartment_984", "id": "reaction_10335618", "reactome": "R-XTR-8862300", "name": "LYZ binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10332888" ], "products": [ "species_10335616" ], "modifiers": [], "additional_components": [ "ENSXETG00000037293", "A0A6I8RID5", "ENSXETG00000037293", "species_6789198" ] }, "reaction_10327260": { "compartment": "compartment_12045", "id": "reaction_10327260", "reactome": "R-XTR-3134800", "name": "STING dimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324507" ], "products": [ "species_10326753" ], "modifiers": [ [ "species_10327258", "catalyst" ] ], "additional_components": [ "ENSXETG00000016088", "A8E5V9", "ENSXETG00000016088", "ENSXETG00000016088" ] }, "reaction_10327352": { "compartment": "compartment_12045", "id": "reaction_10327352", "reactome": "R-XTR-3244643", "name": "STING binds cyclic GMP-AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326753", "species_3244587" ], "products": [ "species_10327350" ], "modifiers": [], "additional_components": [ "A8E5V9", "ENSXETG00000016088", "species_3244587", "A8E5V9", "ENSXETG00000016088" ] }, "reaction_10326762": { "compartment": "compartment_12045", "id": "reaction_10326762", "reactome": "R-XTR-2396009", "name": "STING binds c-di-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326753", "species_2395973" ], "products": [ "species_10326760" ], "modifiers": [], "additional_components": [ "A8E5V9", "ENSXETG00000016088", "species_2395973", "A8E5V9", "ENSXETG00000016088" ] }, "reaction_10337738": { "compartment": "compartment_70101", "id": "reaction_10337738", "reactome": "R-XTR-9604480", "name": "NFkB complex translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313343" ], "products": [ "species_10313349" ], "modifiers": [], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173" ] }, "reaction_10329903": { "compartment": "compartment_876", "id": "reaction_10329903", "reactome": "R-XTR-5621571", "name": "CD209 binds ICAM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314660", "species_10329899" ], "products": [ "species_10329901" ], "modifiers": [], "additional_components": [ "A0A6I8PWA4", "ENSXETG00000027690", "A0A6I8Q7U5", "ENSXETG00000022064", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "A0A6I8PWA4", "ENSXETG00000027690", "A0A6I8Q7U5", "ENSXETG00000022064" ] }, "reaction_10330318": { "compartment": "compartment_7660", "id": "reaction_10330318", "reactome": "R-XTR-5660980", "name": "p-S276-RELA binds RELB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330314", "species_10329932" ], "products": [ "species_10330316" ], "modifiers": [], "additional_components": [ "ENSXETG00000031521", "ENSXETG00000026173", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8PZ90", "ENSXETG00000031521" ] }, "reaction_10329907": { "compartment": "compartment_876", "id": "reaction_10329907", "reactome": "R-XTR-5621615", "name": "CD209 binds ICAM3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314666", "species_10329899", "species_74112" ], "products": [ "species_10329905" ], "modifiers": [], "additional_components": [ "A0A6I8Q7U5", "ENSXETG00000022064", "A0A6I8PWA4", "ENSXETG00000027690", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "species_74112", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "A0A6I8Q7U5", "ENSXETG00000022064", "A0A6I8PWA4", "ENSXETG00000027690" ] }, "reaction_10329834": { "compartment": "compartment_876", "id": "reaction_10329834", "reactome": "R-XTR-5607755", "name": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329832" ], "products": [ "species_10329827" ], "modifiers": [], "additional_components": [ "ENSXETG00000003578", "ENSXETG00000003578" ] }, "reaction_10329830": { "compartment": "compartment_876", "id": "reaction_10329830", "reactome": "R-XTR-5607735", "name": "p-Y753,Y759-PLCG2 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10329827", "catalyst" ] ], "additional_components": [ "ENSXETG00000003578" ] }, "reaction_10335614": { "compartment": "compartment_876", "id": "reaction_10335614", "reactome": "R-XTR-8858500", "name": "CLEC10A binds Tn-MUC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335610", "species_10335598" ], "products": [ "species_10335612" ], "modifiers": [], "additional_components": [ "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "ENSXETG00000041320", "A0A6I8Q6M7", "ENSXETG00000041320", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522" ] }, "reaction_10332377": { "compartment": "compartment_70101", "id": "reaction_10332377", "reactome": "R-XTR-6788999", "name": "HV1-mediated H+ transfer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10332374", "catalyst" ] ], "additional_components": [ "Q5M8L8", "ENSXETT00000045238" ] }, "reaction_10317728": { "compartment": "compartment_70101", "id": "reaction_10317728", "reactome": "R-XTR-418436", "name": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10315942", "catalyst" ] ], "additional_components": [ "ENSXETG00000011979" ] }, "reaction_10313407": { "compartment": "compartment_984", "id": "reaction_10313407", "reactome": "R-XTR-169719", "name": "Secreted CD14 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313202", "species_10313403" ], "products": [ "species_10313200", "species_10313405" ], "modifiers": [], "additional_components": [ "species_166005", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "ENSXETG00000031516", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "A0A6I8PVH6", "ENSXETG00000031516", "species_166005" ] }, "reaction_10313216": { "compartment": "compartment_984", "id": "reaction_10313216", "reactome": "R-XTR-166038", "name": "GPI-bound CD14 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313202", "species_10313212" ], "products": [ "species_10313200", "species_10313214" ], "modifiers": [], "additional_components": [ "species_166005", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "ENSXETG00000031516", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "A0A6I8PVH6", "ENSXETG00000031516", "species_166005" ] }, "reaction_10326889": { "compartment": "compartment_876", "id": "reaction_10326889", "reactome": "R-XTR-2559456", "name": "TIRAP binds PIP2-rich regions in the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326885", "species_179856" ], "products": [ "species_10326887" ], "modifiers": [], "additional_components": [ "ENSXETG00000031764", "species_179856", "A0A6I8QHE1", "ENSXETG00000031764" ] }, "reaction_10313206": { "compartment": "compartment_984", "id": "reaction_10313206", "reactome": "R-XTR-166015", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313200", "species_166005" ], "products": [ "species_10313202" ], "modifiers": [ [ "species_10313204", "inhibitor" ] ], "additional_components": [ "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "species_166005", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "ENSXETG00000017331" ] }, "reaction_10335885": { "compartment": "compartment_984", "id": "reaction_10335885", "reactome": "R-XTR-8869694", "name": "oxPL binds CD14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2186967", "species_10313403" ], "products": [ "species_10335883" ], "modifiers": [], "additional_components": [ "ENSXETG00000031516", "A0A6I8PVH6", "ENSXETG00000031516", "species_2186967" ] }, "reaction_10335881": { "compartment": "compartment_984", "id": "reaction_10335881", "reactome": "R-XTR-8869683", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313200", "species_2186967" ], "products": [ "species_10335879" ], "modifiers": [], "additional_components": [ "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "species_2186967", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015" ] }, "reaction_10313401": { "compartment": "compartment_984", "id": "reaction_10313401", "reactome": "R-XTR-168947", "name": "Ligand binds to TLR10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313395", "species_168948" ], "products": [ "species_10313399" ], "modifiers": [], "additional_components": [ "ENSXETG00000018477", "A0A6I8PMY8", "ENSXETG00000018477" ] }, "reaction_10324331": { "compartment": "compartment_876", "id": "reaction_10324331", "reactome": "R-XTR-1861621", "name": "Cross-linking of FCGRIIA with IgG-coated Ag", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324321", "species_10324327" ], "products": [ "species_10324329" ], "modifiers": [], "additional_components": [ "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8QLS0", "ENSXETG00000041230", "A0A6I8QM25", "ENSXETG00000041230", "A0A6I8PTS9", "ENSXETG00000041230", "A0A6I8RSN1", "ENSXETG00000041230", "A0A6I8PUH7", "ENSXETG00000041230", "A0A6I8S9Z8", "ENSXETG00000041230", "A0A6I8PM56", "ENSXETG00000041230", "A0A6I8RJH0", "ENSXETG00000041230", "A0A6I8PMK7", "ENSXETG00000041230", "A0A6I8RS78", "ENSXETG00000041230", "A0A6I8R4R2", "ENSXETG00000041230", "A0A6I8R767", "ENSXETG00000041230", "A0A6I8RSK9", "ENSXETG00000040383", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326824", "species_10316092" ], "products": [ "species_10326826" ], "modifiers": [], "additional_components": [ "ENSXETG00000036363", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8SNS8", "ENSXETG00000036363" ] }, "reaction_10316104": { "compartment": "compartment_876", "id": "reaction_10316104", "reactome": "R-XTR-210300", "name": "Interaction of DAP12 and TREM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316100", "species_10316092" ], "products": [ "species_10316102" ], "modifiers": [], "additional_components": [ "ENSXETG00000037809", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QSY3", "ENSXETG00000037809" ] }, "reaction_10326264": { "compartment": "compartment_876", "id": "reaction_10326264", "reactome": "R-XTR-2172123", "name": "Interaction of SIGLEC14/15/16 and DAP12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326260", "species_10316092" ], "products": [ "species_10326262" ], "modifiers": [], "additional_components": [ "A0A6I8Q2E3", "ENSXETG00000031297", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8Q2E3", "ENSXETG00000031297", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970" ] }, "reaction_10326651": { "compartment": "compartment_876", "id": "reaction_10326651", "reactome": "R-XTR-2272668", "name": "Interaction of DAP12 and KIR2DS5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315610", "species_10316092" ], "products": [ "species_10326649" ], "modifiers": [], "additional_components": [ "ENSXETG00000032630", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8Q0D7", "ENSXETG00000032630" ] }, "reaction_10325991": { "compartment": "compartment_876", "id": "reaction_10325991", "reactome": "R-XTR-2130151", "name": "Dimerization of DAP12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315608" ], "products": [ "species_10316092" ], "modifiers": [], "additional_components": [ "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786" ] }, "reaction_10326822": { "compartment": "compartment_876", "id": "reaction_10326822", "reactome": "R-XTR-2426566", "name": "Interaction of DAP12 and CLM7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326818", "species_10316092" ], "products": [ "species_10326820" ], "modifiers": [], "additional_components": [ "ENSXETG00000036363", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8SNS8", "ENSXETG00000036363" ] }, "reaction_10316096": { "compartment": "compartment_876", "id": "reaction_10316096", "reactome": "R-XTR-210273", "name": "Interaction of DAP12 and NKp44", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316090", "species_10316092" ], "products": [ "species_10316094" ], "modifiers": [], "additional_components": [ "ENSXETG00000032041", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8PSB6", "ENSXETG00000032041" ] }, "reaction_10320644": { "compartment": "compartment_17906", "id": "reaction_10320644", "reactome": "R-XTR-936564", "name": "NLRX1 inhibits MAVS-DDX58 interaction.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320640", "species_10320636" ], "products": [ "species_10320642" ], "modifiers": [], "additional_components": [ "ENSXETG00000021586", "ENSXETG00000032111", "A0A6I8PQE8", "ENSXETG00000032111", "A0A6I8PYZ4", "ENSXETG00000021586" ] }, "reaction_10338275": { "compartment": "compartment_17906", "id": "reaction_10338275", "reactome": "R-XTR-9709842", "name": "MAVS binds TOMM70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331987", "species_10320636" ], "products": [ "species_10338273" ], "modifiers": [], "additional_components": [ "ENSXETG00000011867", "ENSXETG00000032111", "A0A6I8PQE8", "ENSXETG00000032111", "A0A6I8QP49", "ENSXETG00000011867" ] }, "reaction_10333758": { "compartment": "compartment_6800424", "id": "reaction_10333758", "reactome": "R-XTR-6800426", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333750" ], "products": [ "species_10333756" ], "modifiers": [], "additional_components": [ "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8PUI6", "ENSXETG00000037491", "A0A6I8QHU4", "ENSXETG00000015523", "A0A6I8SNS8", "ENSXETG00000036363", "Q6P2W7", "ENSXETG00000024963", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "Q6GL60", "ENSXETT00000092508", "A0A6I8SYN8", "ENSXETG00000035544", "A0A6I8Q475", "ENSXETG00000035544", "A0A6I8PQG1", "ENSXETG00000034243", "A0A6I8QZT4", "ENSXETG00000015766", "F6WCE6", "ENSXETT00000002749", "Q6NVR9", "ENSXETT00000028394", "A0A6I8SS44", "ENSXETG00000034408", "A1A5G6", "ENSXETG00000007635", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q632", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "Q0VA77", "ENSXETT00000035499", "Q6P8C8", "ENSXETT00000001981", "F6WSE4", "ENSXETT00000003359", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8PQG1", "ENSXETG00000034243", "Q0VA77", "ENSXETT00000035499", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8Q632", "ENSXETG00000041332", "A0A6I8QZT4", "ENSXETG00000015766", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8QHU4", "ENSXETG00000015523", "Q6P2W7", "ENSXETG00000024963", "A0A6I8Q475", "ENSXETG00000035544", "A0A6I8SYN8", "ENSXETG00000035544", "Q6P8C8", "ENSXETT00000001981", "F6WCE6", "ENSXETT00000002749", "Q6NVR9", "ENSXETT00000028394", "Q6GL60", "ENSXETT00000092508", "A1A5G6", "ENSXETG00000007635", "F6WSE4", "ENSXETT00000003359", "A0A6I8SS44", "ENSXETG00000034408", "A0A6I8SNS8", "ENSXETG00000036363", "A0A6I8PUI6", "ENSXETG00000037491" ] }, "reaction_10333460": { "compartment": "compartment_1470028", "id": "reaction_10333460", "reactome": "R-XTR-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333156" ], "products": [ "species_10333220" ], "modifiers": [], "additional_components": [ "Q6DEU1", "ENSXETT00000058038", "Q6P326", "ENSXETG00000021646", "A0A6I8Q5Z6", "ENSXETG00000031325", "A0A6I8SM68", "ENSXETG00000032580", "A0A6I8RCL3", "ENSXETG00000006695", "F7B3J1", "ENSXETT00000011348", "A0A6I8R1G6", "ENSXETG00000007490", "A0A6I8QYH5", "ENSXETG00000035070", "A0A6I8SRS9", "ENSXETG00000016932", "A0A6I8Q0D7", "ENSXETG00000032630", "Q28IX9", "ENSXETT00000096095", "A0A6I8QJX8", "ENSXETG00000010896", "L7N2L6", "ENSXETT00000005874", "A0A6I8S033", "ENSXETG00000009423", "A0A6I8SJ17", "ENSXETG00000016072", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8RMU5", "ENSXETG00000041054", "A0A6I8QYQ6", "ENSXETG00000037779", "A0A6I8RU72", "ENSXETG00000041054", "A0A6I8RSU0", "ENSXETG00000041054", "A0A6I8QAR5", "ENSXETG00000003287", "Q6GL04", "ENSXETT00000067185", "A0A6I8SZP6", "ENSXETG00000021325", "F6TGE8", "ENSXETT00000000571", "A0A6I8SR75", "ENSXETG00000037123", "A0A6I8SKX0", "ENSXETG00000018552", "A0A6I8RTF4", "ENSXETG00000038059", "F7BED4", "ENSXETT00000050679", "A0A6I8RKW5", "ENSXETG00000019013", "Q4V9Y5", "ENSXETT00000029363", "A0A6I8SN57", "ENSXETG00000037611", "A0A6I8QFG6", "ENSXETG00000037805", "Q5I0S8", "ENSXETT00000001376", "A0A6I8Q5Z6", "ENSXETG00000031325", "A0A6I8SRS9", "ENSXETG00000016932", "F7B3J1", "ENSXETT00000011348", "A0A6I8RKW5", "ENSXETG00000019013", "A0A6I8QJX8", "ENSXETG00000010896", "L7N2L6", "ENSXETT00000005874", "A0A6I8RSU0", "ENSXETG00000041054", "A0A6I8RU72", "ENSXETG00000041054", "A0A6I8QYQ6", "ENSXETG00000037779", "A0A6I8RMU5", "ENSXETG00000041054", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8SJ17", "ENSXETG00000016072", "A0A6I8SN57", "ENSXETG00000037611", "A0A6I8S033", "ENSXETG00000009423", "A0A6I8RTF4", "ENSXETG00000038059", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8SR75", "ENSXETG00000037123", "Q4V9Y5", "ENSXETT00000029363", "F7BED4", "ENSXETT00000050679", "A0A6I8QFG6", "ENSXETG00000037805", "A0A6I8SM68", "ENSXETG00000032580", "Q6DEU1", "ENSXETT00000058038", "Q6P326", "ENSXETG00000021646", "A0A6I8RCL3", "ENSXETG00000006695", "A0A6I8R1G6", "ENSXETG00000007490", "Q28IX9", "ENSXETT00000096095", "A0A6I8QYH5", "ENSXETG00000035070", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8QAR5", "ENSXETG00000003287", "F6TGE8", "ENSXETT00000000571", "Q6GL04", "ENSXETT00000067185", "A0A6I8SKX0", "ENSXETG00000018552", "Q5I0S8", "ENSXETT00000001376" ] }, "reaction_10333312": { "compartment": "compartment_6799371", "id": "reaction_10333312", "reactome": "R-XTR-6798749", "name": "Exocytosis of specific granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333882" ], "products": [ "species_10333902" ], "modifiers": [], "additional_components": [ "F6TFI0", "ENSXETT00000050806", "F7B3J1", "ENSXETT00000011348", "A0A6I8QYH5", "ENSXETG00000035070", "L7N3U2", "ENSXETT00000047429", "L7N2L6", "ENSXETT00000005874", "Q28IX9", "ENSXETT00000096095", "A0A6I8SRS9", "ENSXETG00000016932", "Q6P8G1", "ENSXETG00000014290", "A0A6I8SJ17", "ENSXETG00000016072", "Q5BL41", "ENSXETT00000030571", "A0A6I8QJX8", "ENSXETG00000010896", "A0A6I8RSU0", "ENSXETG00000041054", "A0A6I8RU72", "ENSXETG00000041054", "A0A6I8QYQ6", "ENSXETG00000037779", "A0A6I8RMU5", "ENSXETG00000041054", "A0A6I8RCC1", "ENSXETG00000006576", "Q5M7S9", "ENSXETT00000073387", "F6PKQ4", "ENSXETT00000023697", "F6PTR9", "ENSXETT00000028682", "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566", "A0A6I8SKX0", "ENSXETG00000018552", "A0A6I8SR75", "ENSXETG00000037123", "F6T7W4", "ENSXETT00000045926", "Q6GL04", "ENSXETT00000067185", "F6TGE8", "ENSXETT00000000571", "B1H326", "ENSXETT00000060143", "A0A6I8RKW5", "ENSXETG00000019013", "A0A6I8RTF4", "ENSXETG00000038059", "A0A6I8SN57", "ENSXETG00000037611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8RI96", "ENSXETG00000038203", "F7BED4", "ENSXETT00000050679", "A0A6I8PT30", "ENSXETG00000003014", "Q4V9Y5", "ENSXETT00000029363", "A0A6I8QFG6", "ENSXETG00000037805", "A0A6I8SM87", "ENSXETG00000038128", "A0A6I8RUR5", "ENSXETG00000035955", "B5DE93", "ENSXETG00000023695", "A0A6I8R1G6", "ENSXETG00000007490", "A0A6I8QL92", "ENSXETG00000039008", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350", "Q6DEU1", "ENSXETT00000058038", "Q6P326", "ENSXETG00000021646", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8RCL3", "ENSXETG00000006695", "F6PKQ4", "ENSXETT00000023697", "A0A6I8SRS9", "ENSXETG00000016932", "F7B3J1", "ENSXETT00000011348", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "A0A6I8RKW5", "ENSXETG00000019013", "A0A6I8QJX8", "ENSXETG00000010896", "F6T7W4", "ENSXETT00000045926", "L7N2L6", "ENSXETT00000005874", "L7N3U2", "ENSXETT00000047429", "A0A6I8PT30", "ENSXETG00000003014", "A0A6I8RSU0", "ENSXETG00000041054", "A0A6I8RU72", "ENSXETG00000041054", "A0A6I8QYQ6", "ENSXETG00000037779", "A0A6I8RMU5", "ENSXETG00000041054", "A0A6I8RUR5", "ENSXETG00000035955", "A0A6I8SJ17", "ENSXETG00000016072", "A0A6I8RCC1", "ENSXETG00000006576", "Q5M7S9", "ENSXETT00000073387", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8SN57", "ENSXETG00000037611", "A0A6I8RTF4", "ENSXETG00000038059", "Q6P8G1", "ENSXETG00000014290", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8SR75", "ENSXETG00000037123", "A0A6I8SM87", "ENSXETG00000038128", "Q4V9Y5", "ENSXETT00000029363", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350", "A0A6I8QL92", "ENSXETG00000039008", "F7BED4", "ENSXETT00000050679", "B1H326", "ENSXETT00000060143", "F6TFI0", "ENSXETT00000050806", "A0A6I8QFG6", "ENSXETG00000037805", "B5DE93", "ENSXETG00000023695", "Q6DEU1", "ENSXETT00000058038", "Q6P326", "ENSXETG00000021646", "A0A6I8RCL3", "ENSXETG00000006695", "F6PTR9", "ENSXETT00000028682", "A0A6I8R1G6", "ENSXETG00000007490", "Q28IX9", "ENSXETT00000096095", "A0A6I8QYH5", "ENSXETG00000035070", "F6TGE8", "ENSXETT00000000571", "Q6GL04", "ENSXETT00000067185", "Q5BL41", "ENSXETT00000030571", "A0A6I8SKX0", "ENSXETG00000018552" ] }, "reaction_10332768": { "compartment": "compartment_876", "id": "reaction_10332768", "reactome": "R-XTR-6798743", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10332852" ], "products": [ "species_10332896" ], "modifiers": [], "additional_components": [ "Q5BKE6", "ENSXETT00000089406", "A0A6I8SVI1", "ENSXETG00000012869", "A0A6I8Q0D7", "ENSXETG00000032630", "Q501K5", "ENSXETG00000011814", "F7D5C5", "ENSXETT00000001620", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8QDT0", "ENSXETG00000039678", "Q6P8G1", "ENSXETG00000014290", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "Q5M7S9", "ENSXETT00000073387", "A0A6I8RCC1", "ENSXETG00000006576", "F6PKQ4", "ENSXETT00000023697", "A0A6I8PKK9", "ENSXETG00000033246", "F6T7W4", "ENSXETT00000045926", "A0A6I8SN57", "ENSXETG00000037611", "F6PTR9", "ENSXETT00000028682", "A0A6I8RKW5", "ENSXETG00000019013", "Q28IE5", "ENSXETG00000011864", "A0A6I8PT30", "ENSXETG00000003014", "A0A6I8RID5", "ENSXETG00000037293", "A0A6I8PV16", "ENSXETG00000031089", "A0A6I8RUR5", "ENSXETG00000035955", "A0A6I8PKK9", "ENSXETG00000033246", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "F6PKQ4", "ENSXETT00000023697", "Q501K5", "ENSXETG00000011814", "A0A6I8RID5", "ENSXETG00000037293", "A0A6I8SVI1", "ENSXETG00000012869", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "A0A6I8QDT0", "ENSXETG00000039678", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8RKW5", "ENSXETG00000019013", "F6PTR9", "ENSXETT00000028682", "F6T7W4", "ENSXETT00000045926", "A0A6I8PT30", "ENSXETG00000003014", "A0A6I8RUR5", "ENSXETG00000035955", "A0A6I8RCC1", "ENSXETG00000006576", "Q5M7S9", "ENSXETT00000073387", "A0A6I8SN57", "ENSXETG00000037611", "F7D5C5", "ENSXETT00000001620", "Q5BKE6", "ENSXETT00000089406", "Q6P8G1", "ENSXETG00000014290", "A0A6I8Q0D7", "ENSXETG00000032630", "Q28IE5", "ENSXETG00000011864", "A0A6I8PV16", "ENSXETG00000031089" ] }, "reaction_10333042": { "compartment": "compartment_6799713", "id": "reaction_10333042", "reactome": "R-XTR-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333006" ], "products": [ "species_10333040" ], "modifiers": [], "additional_components": [ "F6ZRG8", "ENSXETT00000037913", "A0A6I8PUI6", "ENSXETG00000037491", "A0A6I8PVI0", "ENSXETG00000010850", "A0A1B8Y5B7", "ENSXETT00000104043", "A0A6I8Q475", "ENSXETG00000035544", "A0A6I8SYN8", "ENSXETG00000035544", "A0A6I8Q0D7", "ENSXETG00000032630", "F6TV21", "ENSXETT00000001805", "B0BM39", "ENSXETT00000065869", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8PYT1", "ENSXETG00000036665", "A0A6I8SS44", "ENSXETG00000034408", "Q28H62", "ENSXETT00000054186", "F6WCE6", "ENSXETT00000002749", "B4F6Y3", "ENSXETG00000026765", "A0A6I8SNS8", "ENSXETG00000036363", "A0A6I8SCB5", "ENSXETG00000018128", "Q6DF40", "ENSXETG00000020403", "A0A6I8PZB2", "ENSXETG00000001905", "A0A6I8SB02", "ENSXETG00000038658", "A0A6I8QZM7", "ENSXETG00000032631", "A0A6I8R329", "ENSXETG00000038658", "A0A6I8PPZ5", "ENSXETG00000038658", "A0A6I8QHU4", "ENSXETG00000015523", "A0A6I8SNU5", "ENSXETG00000031444", "A0A6I8PVI0", "ENSXETG00000010850", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8SNU5", "ENSXETG00000031444", "A0A6I8PYT1", "ENSXETG00000036665", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8R329", "ENSXETG00000038658", "A0A6I8PPZ5", "ENSXETG00000038658", "A0A6I8QZM7", "ENSXETG00000032631", "A0A6I8SB02", "ENSXETG00000038658", "B4F6Y3", "ENSXETG00000026765", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "Q28H62", "ENSXETT00000054186", "A0A6I8QHU4", "ENSXETG00000015523", "A0A6I8Q475", "ENSXETG00000035544", "A0A6I8SYN8", "ENSXETG00000035544", "Q6DF40", "ENSXETG00000020403", "A0A6I8SCB5", "ENSXETG00000018128", "A0A6I8SNS8", "ENSXETG00000036363", "A0A6I8PUI6", "ENSXETG00000037491", "A0A6I8PZB2", "ENSXETG00000001905", "A0A1B8Y5B7", "ENSXETT00000104043", "B0BM39", "ENSXETT00000065869", "F6WCE6", "ENSXETT00000002749", "F6TV21", "ENSXETT00000001805", "F6ZRG8", "ENSXETT00000037913", "A0A6I8SS44", "ENSXETG00000034408" ] }, "reaction_10320878": { "compartment": "compartment_876", "id": "reaction_10320878", "reactome": "R-XTR-981713", "name": "C4b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313268", "species_983438" ], "products": [ "species_10313290" ], "modifiers": [], "additional_components": [ "A0A6I8Q4R4", "ENSXETG00000005203", "A0A6I8Q4R4", "ENSXETG00000005203" ] }, "reaction_10313294": { "compartment": "compartment_984", "id": "reaction_10313294", "reactome": "R-XTR-166795", "name": "Formation of Classical C3 convertase (C4b:C2a complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313290", "species_10313274" ], "products": [ "species_10313292" ], "modifiers": [], "additional_components": [ "A0A6I8Q4R4", "ENSXETG00000005203", "ENSXETG00000041348", "A0A6I8R253", "ENSXETG00000041348", "A0A6I8Q4R4", "ENSXETG00000005203" ] }, "reaction_10313469": { "compartment": "compartment_984", "id": "reaction_10313469", "reactome": "R-XTR-173745", "name": "Factor D cleaves C3(H2O)-bound Factor B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313458" ], "products": [ "species_10313462", "species_10313320" ], "modifiers": [ [ "species_10313466", "catalyst" ] ], "additional_components": [ "A0A6I8S693", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "ENSXETG00000039379", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "ENSXETG00000021646" ] }, "reaction_10313981": { "compartment": "compartment_984", "id": "reaction_10313981", "reactome": "R-XTR-183126", "name": "Factor B binds to surface-associated C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313456", "species_10313326" ], "products": [ "species_10313977" ], "modifiers": [], "additional_components": [ "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379" ] }, "reaction_10320876": { "compartment": "compartment_876", "id": "reaction_10320876", "reactome": "R-XTR-981539", "name": "C3b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313307", "species_983438" ], "products": [ "species_10313326" ], "modifiers": [], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992" ] }, "reaction_10313454": { "compartment": "compartment_984", "id": "reaction_10313454", "reactome": "R-XTR-173739", "name": "Spontaneous hydrolysis of C3 thioester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10313303" ], "products": [ "species_10313314" ], "modifiers": [], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992" ] }, "reaction_10313979": { "compartment": "compartment_876", "id": "reaction_10313979", "reactome": "R-XTR-183122", "name": "Factor D cleaves C3b-bound Factor B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313977" ], "products": [ "species_10313462", "species_10313324" ], "modifiers": [ [ "species_10313466", "catalyst" ] ], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "ENSXETG00000021646" ] }, "reaction_10313460": { "compartment": "compartment_984", "id": "reaction_10313460", "reactome": "R-XTR-173740", "name": "Factor B binds to C3(H2O)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313314", "species_10313456" ], "products": [ "species_10313458" ], "modifiers": [], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "ENSXETG00000039379", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992" ] }, "reaction_10313984": { "compartment": "compartment_984", "id": "reaction_10313984", "reactome": "R-XTR-183130", "name": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313303" ], "products": [ "species_10313307", "species_10313309" ], "modifiers": [ [ "species_10313320", "catalyst" ] ], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992" ] }, "reaction_10334989": { "compartment": "compartment_876", "id": "reaction_10334989", "reactome": "R-XTR-8851436", "name": "CFHR dimers bind C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334985", "species_10313326" ], "products": [ "species_10334987" ], "modifiers": [], "additional_components": [ "A0A6I8PQF3", "ENSXETG00000031728", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10321772": { "compartment": "compartment_876", "id": "reaction_10321772", "reactome": "R-XTR-1006169", "name": "Factor H binds host cell surface markers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320787", "species_1006146" ], "products": [ "species_10320851" ], "modifiers": [], "additional_components": [ "ENSXETG00000031728", "species_1604784", "species_1006168", "species_1604784", "species_1006168", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10320856": { "compartment": "compartment_876", "id": "reaction_10320856", "reactome": "R-XTR-977605", "name": "Factor H displaces Bb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320849" ], "products": [ "species_10313318", "species_10320847" ], "modifiers": [], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8PQF3", "ENSXETG00000031728", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10320853": { "compartment": "compartment_876", "id": "reaction_10320853", "reactome": "R-XTR-977363", "name": "Factor H binds to C3bBb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320787", "species_10313324" ], "products": [ "species_10320849" ], "modifiers": [ [ "species_10320851", "catalyst" ] ], "additional_components": [ "ENSXETG00000031728", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8PQF3", "ENSXETG00000031728", "species_1604784", "species_1006168", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10320791": { "compartment": "compartment_984", "id": "reaction_10320791", "reactome": "R-XTR-976768", "name": "Factor H binds to C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320787", "species_10313307" ], "products": [ "species_10320789" ], "modifiers": [], "additional_components": [ "ENSXETG00000031728", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10320880": { "compartment": "compartment_876", "id": "reaction_10320880", "reactome": "R-XTR-981728", "name": "Factor H binds to membrane-associated C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320787", "species_10313326" ], "products": [ "species_10320847" ], "modifiers": [ [ "species_10320851", "catalyst" ] ], "additional_components": [ "ENSXETG00000031728", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8PQF3", "ENSXETG00000031728", "species_1604784", "species_1006168", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10327043": { "compartment": "compartment_984", "id": "reaction_10327043", "reactome": "R-XTR-2855047", "name": "Hydrolysis of internal thioester in C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10313268" ], "products": [ "species_10313281" ], "modifiers": [], "additional_components": [ "A0A6I8Q4R4", "ENSXETG00000005203", "A0A6I8Q4R4", "ENSXETG00000005203" ] }, "reaction_10313452": { "compartment": "compartment_876", "id": "reaction_10313452", "reactome": "R-XTR-173636", "name": "Formation of classic pathway C5 convertase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313326", "species_10313292" ], "products": [ "species_10313328" ], "modifiers": [], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8R253", "ENSXETG00000041348", "A0A6I8Q4R4", "ENSXETG00000005203", "A0A6I8R253", "ENSXETG00000041348", "A0A6I8Q4R4", "ENSXETG00000005203", "A0A6I8Q3I4", "ENSXETG00000032992" ] }, "reaction_10313333": { "compartment": "compartment_984", "id": "reaction_10313333", "reactome": "R-XTR-166817", "name": "Cleavage of C3 by C3 convertases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313303" ], "products": [ "species_10313307", "species_10313309" ], "modifiers": [ [ "species_10313330", "catalyst" ] ], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8R253", "ENSXETG00000041348", "A0A6I8Q4R4", "ENSXETG00000005203" ] }, "reaction_10337951": { "compartment": "compartment_70101", "id": "reaction_10337951", "reactome": "R-XTR-9645394", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312116" ], "products": [ "species_10313391" ], "modifiers": [ [ "species_10337948", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "Q28DL4", "ENSXETG00000007549" ] }, "reaction_10337966": { "compartment": "compartment_70101", "id": "reaction_10337966", "reactome": "R-XTR-9645501", "name": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320680", "species_10337964" ], "products": [ "species_10337953" ], "modifiers": [], "additional_components": [ "ENSXETG00000007549", "Q28DL4", "ENSXETG00000007549", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "Q28DL4", "ENSXETG00000007549", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337976": { "compartment": "compartment_70101", "id": "reaction_10337976", "reactome": "R-XTR-9645524", "name": "ALPK1:ADP-heptose binds TIFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337937", "species_10337972" ], "products": [ "species_10337974" ], "modifiers": [], "additional_components": [ "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "B5DE70", "ENSXETT00000052013", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337979": { "compartment": "compartment_70101", "id": "reaction_10337979", "reactome": "R-XTR-9645535", "name": "ALPK1 phosphorylates TIFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337974", "species_113592" ], "products": [ "species_29370", "species_10337960" ], "modifiers": [ [ "species_10337974", "catalyst" ] ], "additional_components": [ "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337962": { "compartment": "compartment_70101", "id": "reaction_10337962", "reactome": "R-XTR-9645481", "name": "TIFA oligomerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337960" ], "products": [ "species_10337946" ], "modifiers": [], "additional_components": [ "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337956": { "compartment": "compartment_70101", "id": "reaction_10337956", "reactome": "R-XTR-9645414", "name": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337953", "species_10312116" ], "products": [ "species_10337948" ], "modifiers": [ [ "species_10337953", "catalyst" ] ], "additional_components": [ "Q28DL4", "ENSXETG00000007549", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "Q28DL4", "ENSXETG00000007549", "Q28DL4", "ENSXETG00000007549", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337958": { "compartment": "compartment_70101", "id": "reaction_10337958", "reactome": "R-XTR-9645428", "name": "ALPK1 binds ADP-heptose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9645519", "species_10337935" ], "products": [ "species_10337937" ], "modifiers": [], "additional_components": [ "ENSXETG00000024103", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337968": { "compartment": "compartment_70101", "id": "reaction_10337968", "reactome": "R-XTR-9645520", "name": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337946", "species_10320680" ], "products": [ "species_10337964" ], "modifiers": [], "additional_components": [ "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "ENSXETG00000007549", "Q28DL4", "ENSXETG00000007549", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10330607": { "compartment": "compartment_70101", "id": "reaction_10330607", "reactome": "R-XTR-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10324029", "catalyst" ] ], "additional_components": [ "ENSXETG00000016428" ] }, "reaction_10330623": { "compartment": "compartment_5683628", "id": "reaction_10330623", "reactome": "R-XTR-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330602" ], "products": [ "species_10330621" ], "modifiers": [ [ "species_10320527", "catalyst" ] ], "additional_components": [ "species_8959490", "Q5BIZ2", "ENSXETT00000083554", "Q28FC7", "ENSXETT00000085573", "Q5BIZ2", "ENSXETT00000083554", "Q28FC7", "ENSXETT00000085573", "species_8959490", "Q5FW14", "ENSXETG00000016810", "Q5BKM3", "ENSXETT00000038990", "Q6NVL7", "ENSXETT00000016617", "Q6DFS6", "ENSXETT00000041697", "Q6GL11", "ENSXETG00000021424" ] }, "reaction_10336858": { "compartment": "compartment_70101", "id": "reaction_10336858", "reactome": "R-XTR-8948139", "name": "p-S13-FUNDC1 is dephosphorylated by PGAM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336847" ], "products": [ "species_10336844" ], "modifiers": [ [ "species_10336855", "catalyst" ] ], "additional_components": [ "ENSXETG00000004831", "ENSXETG00000004831", "ENSXETG00000023845" ] }, "reaction_10336851": { "compartment": "compartment_17906", "id": "reaction_10336851", "reactome": "R-XTR-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330653" ], "products": [ "species_10336849" ], "modifiers": [], "additional_components": [ "ENSXETG00000002028", "ENSXETG00000002028" ] }, "reaction_10336867": { "compartment": "compartment_17906", "id": "reaction_10336867", "reactome": "R-XTR-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10336844" ], "products": [ "species_10336864", "species_29370" ], "modifiers": [ [ "species_10336849", "catalyst" ] ], "additional_components": [ "ENSXETG00000004831", "ENSXETG00000004831", "ENSXETG00000002028" ] }, "reaction_10330657": { "compartment": "compartment_70101", "id": "reaction_10330657", "reactome": "R-XTR-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330651" ], "products": [ "species_29372", "species_10330655" ], "modifiers": [], "additional_components": [ "A0A6I8QPJ0", "ENSXETG00000002028", "A4IIM9", "ENSXETT00000004248", "A0A6I8QPJ0", "ENSXETG00000002028", "A4IIM9", "ENSXETT00000004248" ] }, "reaction_10337853": { "compartment": "compartment_7660", "id": "reaction_10337853", "reactome": "R-XTR-9629195", "name": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337843", "species_10337849" ], "products": [ "species_10337851" ], "modifiers": [], "additional_components": [ "ENSXETG00000030606", "Q28D37", "ENSXETT00000104494", "A0A6I8RKR7", "ENSXETG00000035354", "B8QB46", "ENSXETG00000012487", "A0A6I8PVF6", "ENSXETG00000031339", "F7E8S9", "ENSXETT00000020406", "Q28D37", "ENSXETT00000104494", "A0A6I8RKR7", "ENSXETG00000035354", "B8QB46", "ENSXETG00000012487", "A0A6I8PVF6", "ENSXETG00000031339", "F7E8S9", "ENSXETT00000020406", "A0A6I8Q015", "ENSXETG00000030606" ] }, "reaction_10337864": { "compartment": "compartment_7660", "id": "reaction_10337864", "reactome": "R-XTR-9629216", "name": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337851" ], "products": [ "species_10337861", "species_9629218" ], "modifiers": [ [ "species_10337851", "catalyst" ] ], "additional_components": [ "Q28D37", "ENSXETT00000104494", "A0A6I8RKR7", "ENSXETG00000035354", "B8QB46", "ENSXETG00000012487", "A0A6I8PVF6", "ENSXETG00000031339", "F7E8S9", "ENSXETT00000020406", "A0A6I8Q015", "ENSXETG00000030606", "A0A6I8Q015", "ENSXETG00000030606", "Q28D37", "ENSXETT00000104494", "A0A6I8RKR7", "ENSXETG00000035354", "B8QB46", "ENSXETG00000012487", "A0A6I8PVF6", "ENSXETG00000031339", "F7E8S9", "ENSXETT00000020406", "Q28D37", "ENSXETT00000104494", "A0A6I8RKR7", "ENSXETG00000035354", "B8QB46", "ENSXETG00000012487", "A0A6I8PVF6", "ENSXETG00000031339", "F7E8S9", "ENSXETT00000020406", "A0A6I8Q015", "ENSXETG00000030606" ] }, "reaction_10312491": { "compartment": "compartment_7660", "id": "reaction_10312491", "reactome": "R-XTR-110246", "name": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312486" ], "products": [ "species_5635947", "species_10312488" ], "modifiers": [ [ "species_10312486", "catalyst" ] ], "additional_components": [ "A0A6I8QBS0", "ENSXETG00000003533", "A0A6I8QBS0", "ENSXETG00000003533", "A0A6I8QBS0", "ENSXETG00000003533" ] }, "reaction_10337882": { "compartment": "compartment_7660", "id": "reaction_10337882", "reactome": "R-XTR-9629492", "name": "NEIL3 cleaves spiroiminodihydantoin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337879" ], "products": [ "species_9629439", "species_10337872" ], "modifiers": [ [ "species_10337879", "catalyst" ] ], "additional_components": [ "A0A6I8Q015", "ENSXETG00000030606", "A0A6I8Q015", "ENSXETG00000030606", "A0A6I8Q015", "ENSXETG00000030606" ] }, "reaction_10337875": { "compartment": "compartment_7660", "id": "reaction_10337875", "reactome": "R-XTR-9629470", "name": "NEIL3 cleaves 5-guanidinohydantoin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337868" ], "products": [ "species_10337872", "species_9629218" ], "modifiers": [ [ "species_10337868", "catalyst" ] ], "additional_components": [ "A0A6I8Q015", "ENSXETG00000030606", "A0A6I8Q015", "ENSXETG00000030606", "A0A6I8Q015", "ENSXETG00000030606" ] }, "reaction_10328441": { "compartment": "compartment_7660", "id": "reaction_10328441", "reactome": "R-XTR-4085350", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10327128" ], "products": [ "species_10328439", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328589": { "compartment": "compartment_7660", "id": "reaction_10328589", "reactome": "R-XTR-4551648", "name": "SUMOylation of TDG with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10312379" ], "products": [ "species_10328587", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000025927", "Q6DEP7", "ENSXETG00000022072", "A0A6I8RWH5", "ENSXETG00000025927", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328620": { "compartment": "compartment_7660", "id": "reaction_10328620", "reactome": "R-XTR-4568848", "name": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328610", "species_10327136" ], "products": [ "species_10328618", "species_10327128" ], "modifiers": [ [ "species_10328508", "catalyst" ] ], "additional_components": [ "ENSXETT00000057859", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "A8WH10", "ENSXETT00000057859", "ENSXETT00000054232", "ENSXETG00000021519" ] }, "reaction_10327230": { "compartment": "compartment_7660", "id": "reaction_10327230", "reactome": "R-XTR-3000433", "name": "SUMOylation of PML with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327222", "species_10327188" ], "products": [ "species_10327227", "species_10327128" ], "modifiers": [ [ "species_10327222", "catalyst" ] ], "additional_components": [ "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000039978", "ENSXETG00000039978", "ENSXETT00000054232", "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328606": { "compartment": "compartment_7660", "id": "reaction_10328606", "reactome": "R-XTR-4551738", "name": "SUMOylation of TDG with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328443", "species_10312379" ], "products": [ "species_10327128", "species_10328604" ], "modifiers": [ [ "species_10328443", "catalyst" ] ], "additional_components": [ "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462", "ENSXETG00000025927", "ENSXETT00000054232", "ENSXETG00000025927", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462" ] }, "reaction_10328632": { "compartment": "compartment_7660", "id": "reaction_10328632", "reactome": "R-XTR-4568863", "name": "SUMOylation of RAD52 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10312157" ], "products": [ "species_10328630", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000009413", "Q6DEP7", "ENSXETG00000022072", "A0A6I8RDE5", "ENSXETG00000009413", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328682": { "compartment": "compartment_7660", "id": "reaction_10328682", "reactome": "R-XTR-4570553", "name": "SUMOylation of MDC1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328677", "species_10328443" ], "products": [ "species_10327128", "species_10328680" ], "modifiers": [ [ "species_10328443", "catalyst" ] ], "additional_components": [ "ENSXETG00000039209", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462", "ENSXETT00000054232", "ENSXETG00000039209", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462" ] }, "reaction_10328644": { "compartment": "compartment_7660", "id": "reaction_10328644", "reactome": "R-XTR-4568914", "name": "SUMOylation of BLM with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328443", "species_10328636" ], "products": [ "species_10328642", "species_10327128" ], "modifiers": [ [ "species_10328443", "catalyst" ] ], "additional_components": [ "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462", "ENSXETG00000007847", "ENSXETG00000007847", "ENSXETT00000054232", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462" ] }, "reaction_10328692": { "compartment": "compartment_7660", "id": "reaction_10328692", "reactome": "R-XTR-4570554", "name": "SUMOylation of MDC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328677" ], "products": [ "species_10328690", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000039209", "Q6DEP7", "ENSXETG00000022072", "A0A6I8SUQ0", "ENSXETG00000039209", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10327201": { "compartment": "compartment_7660", "id": "reaction_10327201", "reactome": "R-XTR-3000383", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10327188" ], "products": [ "species_10327128", "species_10327198" ], "modifiers": [ [ "species_10327128", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000039978", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "A0A6I8SBS8", "ENSXETG00000039978", "ENSXETT00000054232" ] }, "reaction_10328673": { "compartment": "compartment_7660", "id": "reaction_10328673", "reactome": "R-XTR-4570528", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328663" ], "products": [ "species_10327128", "species_10328671" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000033244", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "A0A6I8PUF7", "ENSXETG00000033244", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328579": { "compartment": "compartment_7660", "id": "reaction_10328579", "reactome": "R-XTR-4551616", "name": "SUMOylation of RPA1 (RPA70) with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328443", "species_10311307" ], "products": [ "species_10328576", "species_10327128" ], "modifiers": [ [ "species_10328443", "catalyst" ] ], "additional_components": [ "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462", "ENSXETG00000013538", "ENSXETG00000013538", "ENSXETT00000054232", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462" ] }, "reaction_10328649": { "compartment": "compartment_7660", "id": "reaction_10328649", "reactome": "R-XTR-4570485", "name": "SUMOylation of Histone H4 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313794", "species_10327222" ], "products": [ "species_10328647", "species_10327128" ], "modifiers": [ [ "species_10327222", "catalyst" ] ], "additional_components": [ "ENSXETG00000035354", "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000035354", "ENSXETT00000054232", "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328739": { "compartment": "compartment_7660", "id": "reaction_10328739", "reactome": "R-XTR-4616015", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328729" ], "products": [ "species_10328737", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETT00000023583", "Q6DEP7", "ENSXETG00000022072", "F6QFY1", "ENSXETT00000023583", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328659": { "compartment": "compartment_7660", "id": "reaction_10328659", "reactome": "R-XTR-4570496", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313794", "species_10327136" ], "products": [ "species_10328657", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "ENSXETG00000035354", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "A0A6I8RKR7", "ENSXETG00000035354", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328722": { "compartment": "compartment_7660", "id": "reaction_10328722", "reactome": "R-XTR-4615889", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10321877" ], "products": [ "species_10328720", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000005253", "A0A6I8SGY5", "ENSXETG00000005253", "Q6DEP7", "ENSXETG00000022072", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328845": { "compartment": "compartment_7660", "id": "reaction_10328845", "reactome": "R-XTR-4719436", "name": "PIAS2,3,4 SUMOylate RORA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10317102" ], "products": [ "species_10328843", "species_10327128" ], "modifiers": [ [ "species_10328832", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000021123", "Q6DEP7", "ENSXETG00000022072", "A0A6I8QBV8", "ENSXETG00000021123", "ENSXETT00000054232", "A0A6I8Q277", "ENSXETG00000021519", "A0A6I8S7F8", "ENSXETG00000018642" ] }, "reaction_10328572": { "compartment": "compartment_7660", "id": "reaction_10328572", "reactome": "R-XTR-4546386", "name": "PIAS1,3 SUMOylates NR5A1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10317110" ], "products": [ "species_10328570", "species_10327128" ], "modifiers": [ [ "species_10328492", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETT00000025024", "F7EHW3", "ENSXETT00000025024", "Q6DEP7", "ENSXETG00000022072", "ENSXETT00000054232", "ENSXETG00000018642" ] }, "reaction_10328511": { "compartment": "compartment_7660", "id": "reaction_10328511", "reactome": "R-XTR-4090390", "name": "PIAS1,2-1 SUMOylates AR with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10317088" ], "products": [ "species_10327128", "species_10328504" ], "modifiers": [ [ "species_10328508", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000005089", "ENSXETT00000054232", "A0A6I8RK73", "ENSXETG00000005089", "Q6DEP7", "ENSXETG00000022072", "ENSXETG00000021519" ] }, "reaction_10328942": { "compartment": "compartment_7660", "id": "reaction_10328942", "reactome": "R-XTR-4755494", "name": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328932" ], "products": [ "species_10327128", "species_10328940" ], "modifiers": [ [ "species_10328508", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "CHEBI:77361", "F7EHW3", "ENSXETT00000025024", "ENSXETT00000054232", "CHEBI:77361", "F7EHW3", "ENSXETT00000025024", "Q6DEP7", "ENSXETG00000022072", "ENSXETG00000021519" ] }, "reaction_10328536": { "compartment": "compartment_7660", "id": "reaction_10328536", "reactome": "R-XTR-4341025", "name": "SUMOylation of NR3C1 (GR) with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328523" ], "products": [ "species_10328534", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "A0A6I8S149", "ENSXETG00000040373", "Q6DEP7", "ENSXETG00000022072", "A0A6I8S149", "ENSXETG00000040373", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328548": { "compartment": "compartment_7660", "id": "reaction_10328548", "reactome": "R-XTR-4341073", "name": "PIAS3 SUMOylates PGR with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317074", "species_10327136" ], "products": [ "species_10328546", "species_10327128" ], "modifiers": [ [ "species_10328492", "catalyst" ] ], "additional_components": [ "ENSXETT00000040897", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "F6SI83", "ENSXETT00000040897", "ENSXETT00000054232", "ENSXETG00000018642" ] }, "reaction_10328951": { "compartment": "compartment_7660", "id": "reaction_10328951", "reactome": "R-XTR-4755524", "name": "SUMOylation of NR1I2 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328944", "species_10327222" ], "products": [ "species_10328949", "species_10327128" ], "modifiers": [], "additional_components": [ "A0A6I8RH34", "ENSXETG00000031759", "CHEBI:28077", "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232", "CHEBI:28077", "A0A6I8RH34", "ENSXETG00000031759", "ENSXETT00000054232" ] }, "reaction_10328561": { "compartment": "compartment_7660", "id": "reaction_10328561", "reactome": "R-XTR-4546385", "name": "PIAS1,3 SUMOylates NR5A1 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317110", "species_10327209" ], "products": [ "species_10327128", "species_10328559" ], "modifiers": [ [ "species_10328492", "catalyst" ] ], "additional_components": [ "ENSXETT00000025024", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "ENSXETT00000054232", "ENSXETT00000025024", "ENSXETG00000018642" ] }, "reaction_10328835": { "compartment": "compartment_7660", "id": "reaction_10328835", "reactome": "R-XTR-4719413", "name": "PIAS2,3,4 SUMOylate RORA with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327209", "species_10317102" ], "products": [ "species_10327128", "species_10328830" ], "modifiers": [ [ "species_10328832", "catalyst" ] ], "additional_components": [ "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "ENSXETG00000021123", "ENSXETT00000054232", "ENSXETG00000021123", "A0A6I8Q277", "ENSXETG00000021519", "A0A6I8S7F8", "ENSXETG00000018642" ] }, "reaction_10328495": { "compartment": "compartment_7660", "id": "reaction_10328495", "reactome": "R-XTR-4090288", "name": "PIAS1,3 SUMOylate MBD1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328479" ], "products": [ "species_10327128", "species_10328488" ], "modifiers": [ [ "species_10328492", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000040845", "ENSXETT00000054232", "A0A6I8RGR4", "ENSXETG00000040845", "Q6DEP7", "ENSXETG00000022072", "ENSXETG00000018642" ] }, "reaction_10328219": { "compartment": "compartment_7660", "id": "reaction_10328219", "reactome": "R-XTR-3782535", "name": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328201" ], "products": [ "species_10327128", "species_10328216" ], "modifiers": [ [ "species_10320733", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "A0A6I8QJW7", "ENSXETG00000019245", "A0A6I8RRG3", "ENSXETG00000040574", "A0A6I8RGG7", "ENSXETG00000035980", "ENSXETT00000054232", "A0A6I8RRG3", "ENSXETG00000040574", "A0A6I8RGG7", "ENSXETG00000035980", "Q6DEP7", "ENSXETG00000022072", "A0A6I8QJW7", "ENSXETG00000019245", "ENSXETG00000019245" ] }, "reaction_10328336": { "compartment": "compartment_7660", "id": "reaction_10328336", "reactome": "R-XTR-3900177", "name": "SUMOylation of DDX5 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328325" ], "products": [ "species_10327128", "species_10328333" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETT00000044525", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "F7CZ58", "ENSXETT00000044525", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10337527": { "compartment": "compartment_7660", "id": "reaction_10337527", "reactome": "R-XTR-9023860", "name": "Histone acetyltransferases are recruited to the TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337523", "species_10337509" ], "products": [ "species_10337525" ], "modifiers": [], "additional_components": [ "Q6DEQ4", "ENSXETT00000056546", "Q28GG8", "ENSXETT00000018725", "L7N2Q7", "ENSXETT00000009600", "Q8AWH1", "ENSXETG00000025867", "CHEBI:142773", "species_193066", "species_193132", "CHEBI:27974", "F7CZ58", "ENSXETT00000044525", "Q28F07", "ENSXETT00000094658", "ENSXETG00000041035", "A0A6I8SAY5", "ENSXETG00000041035", "Q6DEQ4", "ENSXETT00000056546", "Q28GG8", "ENSXETT00000018725", "L7N2Q7", "ENSXETT00000009600", "Q8AWH1", "ENSXETG00000025867", "CHEBI:142773", "species_193066", "species_193132", "CHEBI:27974", "F7CZ58", "ENSXETT00000044525", "Q28F07", "ENSXETT00000094658" ] }, "reaction_10317879": { "compartment": "compartment_984", "id": "reaction_10317879", "reactome": "R-XTR-420489", "name": "Parathyroid hormone receptor can bind parathyroid hormone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317875", "species_10317871" ], "products": [ "species_10317877" ], "modifiers": [], "additional_components": [ "ENSXETG00000037389", "Q5G7I8", "ENSXETT00000000004", "F6UDH6", "ENSXETT00000022720", "Q5G7I8", "ENSXETT00000000004", "F6UDH6", "ENSXETT00000022720", "A0A6I8QXF2", "ENSXETG00000037389" ] }, "reaction_10318448": { "compartment": "compartment_984", "id": "reaction_10318448", "reactome": "R-XTR-444773", "name": "EGF-TM7 receptors bind chondroitin sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444761", "species_10318444" ], "products": [ "species_10318446" ], "modifiers": [], "additional_components": [ "F6WSE4", "ENSXETT00000003359", "F6WSE4", "ENSXETT00000003359", "species_444761" ] }, "reaction_10317843": { "compartment": "compartment_984", "id": "reaction_10317843", "reactome": "R-XTR-420214", "name": "The adrenomedullin receptor can bind adrenomedullin and intermedin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317829", "species_10317839" ], "products": [ "species_10317841" ], "modifiers": [], "additional_components": [ "A0A6I8SCW9", "ENSXETG00000040245", "A0A6I8REF2", "ENSXETG00000034576", "A0A6I8QAL9", "ENSXETG00000035598", "Q0P4Y4", "ENSXETT00000074242", "A0A6I8QAL9", "ENSXETG00000035598", "Q0P4Y4", "ENSXETT00000074242", "A0A6I8SCW9", "ENSXETG00000040245", "A0A6I8REF2", "ENSXETG00000034576" ] }, "reaction_10317901": { "compartment": "compartment_984", "id": "reaction_10317901", "reactome": "R-XTR-420739", "name": "GPRC6A can bind L-alpha amino acids and calcium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_420706", "species_10317897" ], "products": [ "species_10317899" ], "modifiers": [], "additional_components": [ "species_74112", "CHEBI:32551", "species_29468", "species_29498", "ENSXETG00000032935", "A0A6I8PQL7", "ENSXETG00000032935", "species_74112", "CHEBI:32551", "species_29468", "species_29498" ] }, "reaction_10327557": { "compartment": "compartment_876", "id": "reaction_10327557", "reactome": "R-XTR-3296233", "name": "T2Rs bind bitter-tasting compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320034", "species_3296423" ], "products": [ "species_10320036" ], "modifiers": [], "additional_components": [ "Q2AB79", "ENSXETT00000093107", "Q2AB72", "ENSXETT00000061687", "Q2AB77", "ENSXETT00000063907", "Q2AB63", "ENSXETT00000061269", "Q2AB68", "ENSXETT00000060826", "Q2AB52", "ENSXETT00000063621", "Q2AB53", "ENSXETT00000018688", "Q2AB48", "ENSXETT00000065249", "Q2AB51", "ENSXETT00000063088", "Q2AB44", "ENSXETT00000066089", "Q2AB45", "ENSXETT00000079130", "Q2AB41", "ENSXETT00000061480", "Q2AB42", "ENSXETT00000065552", "Q2AB38", "ENSXETT00000033481", "Q2AB39", "ENSXETT00000082983", "Q2AB34", "ENSXETT00000060343", "Q2AB35", "ENSXETT00000062616", "A0A6I8RXG4", "ENSXETG00000036502", "A0A6I8S8Y1", "ENSXETG00000038186", "A0A6I8Q8V5", "ENSXETG00000035342", "A0A6I8R2L9", "ENSXETG00000036502", "A0A6I8PTF7", "ENSXETG00000036502", "A0A6I8Q288", "ENSXETG00000031892", "A0A6I8PS37", "ENSXETG00000032405", "A0A6I8PSM4", "ENSXETG00000008531", "A0A6I8PK15", "ENSXETG00000027471", "A0A6I8PQY6", "ENSXETG00000040729", "A0A6I8PJF9", "ENSXETG00000040152", "CHEBI:3193", "species_76328", "CHEBI:3768", "CHEBI:10093", "CHEBI:17814", "species_40727", "CHEBI:8206", "CHEBI:48923", "CHEBI:28973", "CHEBI:73228", "CHEBI:23359", "CHEBI:28241", "CHEBI:73226", "CHEBI:73224", "CHEBI:65408", "CHEBI:3944", "CHEBI:73235", "CHEBI:73231", "CHEBI:16226", "CHEBI:27613", "CHEBI:5547", "CHEBI:2825", "CHEBI:73232", "CHEBI:18305", "CHEBI:3445", "CHEBI:36773", "CHEBI:2622", "CHEBI:73237", "CHEBI:2366", "CHEBI:3941", "CHEBI:7939", "CHEBI:351346", "CHEBI:8692", "CHEBI:73239", "CHEBI:15854", "CHEBI:9162", "CHEBI:26948", "CHEBI:50042", "CHEBI:69236", "CHEBI:73222", "CHEBI:17698", "CHEBI:73236", "CHEBI:2853", "CHEBI:3193", "species_76328", "CHEBI:3768", "CHEBI:10093", "CHEBI:17814", "species_40727", "CHEBI:8206", "CHEBI:48923", "CHEBI:28973", "CHEBI:73228", "CHEBI:23359", "CHEBI:28241", "CHEBI:73226", "CHEBI:73224", "CHEBI:65408", "CHEBI:3944", "CHEBI:73235", "CHEBI:73231", "CHEBI:16226", "CHEBI:27613", "CHEBI:5547", "CHEBI:2825", "CHEBI:73232", "CHEBI:18305", "CHEBI:3445", "CHEBI:36773", "CHEBI:2622", "CHEBI:73237", "CHEBI:2366", "CHEBI:3941", "CHEBI:7939", "CHEBI:351346", "CHEBI:8692", "CHEBI:73239", "CHEBI:15854", "CHEBI:9162", "CHEBI:26948", "CHEBI:50042", "CHEBI:69236", "CHEBI:73222", "CHEBI:17698", "CHEBI:73236", "CHEBI:2853", "Q2AB79", "ENSXETT00000093107", "Q2AB72", "ENSXETT00000061687", "Q2AB77", "ENSXETT00000063907", "Q2AB63", "ENSXETT00000061269", "Q2AB68", "ENSXETT00000060826", "Q2AB52", "ENSXETT00000063621", "Q2AB53", "ENSXETT00000018688", "Q2AB48", "ENSXETT00000065249", "Q2AB51", "ENSXETT00000063088", "Q2AB44", "ENSXETT00000066089", "Q2AB45", "ENSXETT00000079130", "Q2AB41", "ENSXETT00000061480", "Q2AB42", "ENSXETT00000065552", "Q2AB38", "ENSXETT00000033481", "Q2AB39", "ENSXETT00000082983", "Q2AB34", "ENSXETT00000060343", "Q2AB35", "ENSXETT00000062616", "A0A6I8RXG4", "ENSXETG00000036502", "A0A6I8S8Y1", "ENSXETG00000038186", "A0A6I8Q8V5", "ENSXETG00000035342", "A0A6I8R2L9", "ENSXETG00000036502", "A0A6I8PTF7", "ENSXETG00000036502", "A0A6I8Q288", "ENSXETG00000031892", "A0A6I8PS37", "ENSXETG00000032405", "A0A6I8PSM4", "ENSXETG00000008531", "A0A6I8PK15", "ENSXETG00000027471", "A0A6I8PQY6", "ENSXETG00000040729", "A0A6I8PJF9", "ENSXETG00000040152" ] }, "reaction_10316852": { "compartment": "compartment_984", "id": "reaction_10316852", "reactome": "R-XTR-373075", "name": "Metabotropic glutamate receptors bind glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316848", "species_210382" ], "products": [ "species_10316850" ], "modifiers": [], "additional_components": [ "ENSXETG00000006732", "species_210382", "A0A6I8RDQ8", "ENSXETG00000006732" ] }, "reaction_10317446": { "compartment": "compartment_984", "id": "reaction_10317446", "reactome": "R-XTR-390835", "name": "DRD1,5 bind DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317442", "species_380873" ], "products": [ "species_10317444" ], "modifiers": [], "additional_components": [ "ENSXETG00000026496", "species_351601", "A0A6I8PSM8", "ENSXETG00000026496" ] }, "reaction_10317454": { "compartment": "compartment_984", "id": "reaction_10317454", "reactome": "R-XTR-390909", "name": "HRH2 binds hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317450", "species_390899" ], "products": [ "species_10317452" ], "modifiers": [], "additional_components": [ "ENSXETG00000029997", "species_390899", "A0A6I8Q5E3", "ENSXETG00000029997" ] }, "reaction_10317462": { "compartment": "compartment_984", "id": "reaction_10317462", "reactome": "R-XTR-390912", "name": "HRH1 binds hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317458", "species_390899" ], "products": [ "species_10317460" ], "modifiers": [], "additional_components": [ "ENSXETG00000007717", "species_390899", "A0A6I8QYI9", "ENSXETG00000007717" ] }, "reaction_10317438": { "compartment": "compartment_984", "id": "reaction_10317438", "reactome": "R-XTR-390649", "name": "CHRM1,3,5 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317434", "species_372533" ], "products": [ "species_10317436" ], "modifiers": [], "additional_components": [ "A0A6I8PJ30", "ENSXETG00000017868", "A0A6I8SRX2", "ENSXETG00000037602", "species_372533", "A0A6I8PJ30", "ENSXETG00000017868", "A0A6I8SRX2", "ENSXETG00000037602" ] }, "reaction_10337759": { "compartment": "compartment_984", "id": "reaction_10337759", "reactome": "R-XTR-9611839", "name": "3-agonists bind ADRB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9611836", "species_10319102" ], "products": [ "species_10337757" ], "modifiers": [], "additional_components": [ "ENSXETG00000030790", "A0A6I8PZ77", "ENSXETG00000030790" ] }, "reaction_10317422": { "compartment": "compartment_984", "id": "reaction_10317422", "reactome": "R-XTR-390641", "name": "ADRA1A,B,D bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317414", "species_390627" ], "products": [ "species_10317416" ], "modifiers": [ [ "species_10317420", "catalyst" ], [ "species_10317418", "inhibitor" ] ], "additional_components": [ "F6SBD0", "ENSXETT00000037826", "A0A6I8RMZ6", "ENSXETG00000035197", "CHEBI:28918", "CHEBI:18357", "CHEBI:28918", "CHEBI:18357", "F6SBD0", "ENSXETT00000037826", "A0A6I8RMZ6", "ENSXETG00000035197", "F6SBD0", "ENSXETT00000037826", "A0A6I8RMZ6", "ENSXETG00000035197", "F6SBD0", "ENSXETT00000037826", "A0A6I8RMZ6", "ENSXETG00000035197" ] }, "reaction_10337755": { "compartment": "compartment_984", "id": "reaction_10337755", "reactome": "R-XTR-9609310", "name": "-blockers bind ADRB1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9609307", "species_10319102" ], "products": [ "species_10337753" ], "modifiers": [], "additional_components": [ "ENSXETG00000030790", "A0A6I8PZ77", "ENSXETG00000030790" ] }, "reaction_10337761": { "compartment": "compartment_984", "id": "reaction_10337761", "reactome": "R-XTR-9611852", "name": "ADRB3 bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10319102" ], "products": [ "species_10319104" ], "modifiers": [ [ "species_10337757", "catalyst" ], [ "species_10337753", "inhibitor" ] ], "additional_components": [ "CHEBI:28918", "CHEBI:18357", "ENSXETG00000030790", "A0A6I8PZ77", "ENSXETG00000030790", "CHEBI:28918", "CHEBI:18357", "A0A6I8PZ77", "ENSXETG00000030790", "A0A6I8PZ77", "ENSXETG00000030790" ] }, "reaction_10317574": { "compartment": "compartment_984", "id": "reaction_10317574", "reactome": "R-XTR-391211", "name": "Trace amine-associated receptors can bind trace amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317570", "species_391200" ], "products": [ "species_10317572" ], "modifiers": [], "additional_components": [ "A0A6I8RAX0", "ENSXETG00000039183", "species_391200", "A0A6I8RAX0", "ENSXETG00000039183" ] }, "reaction_10317480": { "compartment": "compartment_984", "id": "reaction_10317480", "reactome": "R-XTR-390929", "name": "HTR1 and 5A receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10317476" ], "products": [ "species_10317478" ], "modifiers": [], "additional_components": [ "A0A6I8R5Z0", "ENSXETG00000038202", "A0A6I8QW91", "ENSXETG00000040924", "A0A6I8QWR5", "ENSXETG00000036447", "A0A6I8R5Z0", "ENSXETG00000038202", "A0A6I8QW91", "ENSXETG00000040924", "A0A6I8QWR5", "ENSXETG00000036447", "species_114523" ] }, "reaction_10317496": { "compartment": "compartment_984", "id": "reaction_10317496", "reactome": "R-XTR-390931", "name": "5-HT4, 6 and 7 receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10317492" ], "products": [ "species_10317494" ], "modifiers": [], "additional_components": [ "ENSXETG00000031961", "A0A6I8PXU4", "ENSXETG00000031961", "species_114523" ] }, "reaction_10338203": { "compartment": "compartment_984", "id": "reaction_10338203", "reactome": "R-XTR-9693347", "name": "HTR1A binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338199", "species_114523" ], "products": [ "species_10338201" ], "modifiers": [], "additional_components": [ "ENSXETT00000025697", "species_114523", "F7CKP0", "ENSXETT00000025697" ] }, "reaction_10317488": { "compartment": "compartment_984", "id": "reaction_10317488", "reactome": "R-XTR-390930", "name": "5-HT2 receptor can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10317484" ], "products": [ "species_10317486" ], "modifiers": [], "additional_components": [ "ENSXETT00000009523", "F7D3H9", "ENSXETT00000009523", "species_114523" ] }, "reaction_10334962": { "compartment": "compartment_876", "id": "reaction_10334962", "reactome": "R-XTR-8851298", "name": "GPR143 binds L-Dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10319146", "species_8851314" ], "products": [ "species_10319148" ], "modifiers": [], "additional_components": [ "ENSXETT00000044971", "species_8851314", "F6TV02", "ENSXETT00000044971" ] }, "reaction_10334041": { "compartment": "compartment_984", "id": "reaction_10334041", "reactome": "R-XTR-6805205", "name": "GPR35 binds kynurenic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334037", "species_6805204" ], "products": [ "species_10334039" ], "modifiers": [], "additional_components": [ "ENSXETG00000032766", "species_6805204", "A0A6I8PMC3", "ENSXETG00000032766" ] }, "reaction_10318999": { "compartment": "compartment_984", "id": "reaction_10318999", "reactome": "R-XTR-517536", "name": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318995", "species_517533" ], "products": [ "species_10318997" ], "modifiers": [], "additional_components": [ "ENSXETG00000032224", "species_517533", "A0A6I8Q5A1", "ENSXETG00000032224" ] }, "reaction_10318398": { "compartment": "compartment_984", "id": "reaction_10318398", "reactome": "R-XTR-444527", "name": "FPR is a receptor for formyl peptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318394", "species_444519" ], "products": [ "species_10318396" ], "modifiers": [], "additional_components": [ "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8Q632", "ENSXETG00000041332", "species_444519", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8Q632", "ENSXETG00000041332" ] }, "reaction_10318384": { "compartment": "compartment_984", "id": "reaction_10318384", "reactome": "R-XTR-444476", "name": "FPRL2 receptor binds a wide range of ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318376", "species_10318380" ], "products": [ "species_10318382" ], "modifiers": [], "additional_components": [ "A0A6I8Q632", "ENSXETG00000041332", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8SM80", "ENSXETG00000041332", "ENSXETT00000057031", "Q6DJ66", "ENSXETT00000057031", "A0A6I8Q632", "ENSXETG00000041332", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8SM80", "ENSXETG00000041332" ] }, "reaction_10317308": { "compartment": "compartment_984", "id": "reaction_10317308", "reactome": "R-XTR-388560", "name": "Endothelin receptors bind endothelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317300", "species_10317304" ], "products": [ "species_10317306" ], "modifiers": [], "additional_components": [ "ENSXETG00000041205", "ENSXETT00000033726", "F6RQM0", "ENSXETT00000033726", "A0A6I8QC71", "ENSXETG00000041205" ] }, "reaction_10316908": { "compartment": "compartment_984", "id": "reaction_10316908", "reactome": "R-XTR-373791", "name": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316886", "species_10316904" ], "products": [ "species_10316906" ], "modifiers": [], "additional_components": [ "F6XNR7", "ENSXETT00000034054", "A0A6I8T2T2", "ENSXETG00000036062", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8QDT0", "ENSXETG00000039678", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8QDT0", "ENSXETG00000039678", "F6XNR7", "ENSXETT00000034054", "A0A6I8T2T2", "ENSXETG00000036062" ] }, "reaction_10318316": { "compartment": "compartment_984", "id": "reaction_10318316", "reactome": "R-XTR-443986", "name": "Receptor ACKR2 binds most inflammatory CC chemokines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318292", "species_10318312" ], "products": [ "species_10318314" ], "modifiers": [], "additional_components": [ "ENSXETT00000003445", "A0A6I8SVN2", "ENSXETG00000037100", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "F7C531", "ENSXETT00000003445" ] }, "reaction_10316975": { "compartment": "compartment_984", "id": "reaction_10316975", "reactome": "R-XTR-374214", "name": "Receptors CXCR4 and 7 bind CXCL12 ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316967", "species_10316971" ], "products": [ "species_10316973" ], "modifiers": [], "additional_components": [ "ENSXETT00000032559", "ENSXETT00000068483", "Q5EBF6", "ENSXETT00000068483", "Q07FZ4", "ENSXETT00000032559" ] }, "reaction_10316942": { "compartment": "compartment_984", "id": "reaction_10316942", "reactome": "R-XTR-373813", "name": "Receptor CXCR2 binds ligands CXCL1 to 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316938", "species_10316910" ], "products": [ "species_10316940" ], "modifiers": [], "additional_components": [ "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8QDT0", "ENSXETG00000039678", "ENSXETG00000036062", "A0A6I8T2T2", "ENSXETG00000036062", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8QDT0", "ENSXETG00000039678" ] }, "reaction_10316872": { "compartment": "compartment_876", "id": "reaction_10316872", "reactome": "R-XTR-373342", "name": "CX3CR1 binds CX3CL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316818", "species_10316868" ], "products": [ "species_10316870" ], "modifiers": [], "additional_components": [ "A0A6I8R4J8", "ENSXETG00000041335", "F6RFH7", "ENSXETT00000046189", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8R4J8", "ENSXETG00000041335", "F6RFH7", "ENSXETT00000046189" ] }, "reaction_10335627": { "compartment": "compartment_984", "id": "reaction_10335627", "reactome": "R-XTR-8862733", "name": "CCR2, CCR3 bind CCL13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320058", "species_10320060" ], "products": [ "species_10320062" ], "modifiers": [], "additional_components": [ "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "F6RFH7", "ENSXETT00000046189", "A0A6I8R4J8", "ENSXETG00000041335", "F6RFH7", "ENSXETT00000046189", "A0A6I8R4J8", "ENSXETG00000041335", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100" ] }, "reaction_10316836": { "compartment": "compartment_984", "id": "reaction_10316836", "reactome": "R-XTR-373061", "name": "Receptors CCR3, 4 and 5 bind CCL5 ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316832", "species_10316808" ], "products": [ "species_10316834" ], "modifiers": [], "additional_components": [ "F6RFH7", "ENSXETT00000046189", "A0A6I8R4J8", "ENSXETG00000041335", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "F6RFH7", "ENSXETT00000046189", "A0A6I8R4J8", "ENSXETG00000041335" ] }, "reaction_10334964": { "compartment": "compartment_876", "id": "reaction_10334964", "reactome": "R-XTR-8851352", "name": "CCR8 binds CCL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320070", "species_10316812" ], "products": [ "species_10320072" ], "modifiers": [], "additional_components": [ "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "ENSXETG00000041335", "A0A6I8R4J8", "ENSXETG00000041335", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100" ] }, "reaction_10317326": { "compartment": "compartment_984", "id": "reaction_10317326", "reactome": "R-XTR-388900", "name": "Neurotensin receptors can bind neurotensins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317316", "species_10317320" ], "products": [ "species_10317324" ], "modifiers": [], "additional_components": [ "ENSXETG00000040562", "ENSXETG00000037844", "A0A6I8S4R6", "ENSXETG00000037844", "A0A6I8QBR7", "ENSXETG00000040562" ] }, "reaction_10317048": { "compartment": "compartment_984", "id": "reaction_10317048", "reactome": "R-XTR-375384", "name": "Bombesin-like receptors bind bombesin homologues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317040", "species_10317044" ], "products": [ "species_10317046" ], "modifiers": [], "additional_components": [ "ENSXETT00000045737", "ENSXETG00000030584", "A0A6I8Q016", "ENSXETG00000030584", "F7CE29", "ENSXETT00000045737" ] }, "reaction_10337771": { "compartment": "compartment_984", "id": "reaction_10337771", "reactome": "R-XTR-9615249", "name": "ARBs bind AGRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316946", "species_9615246" ], "products": [ "species_10316960" ], "modifiers": [], "additional_components": [ "ENSXETT00000023026", "B3DLC0", "ENSXETT00000023026" ] }, "reaction_10318464": { "compartment": "compartment_984", "id": "reaction_10318464", "reactome": "R-XTR-444848", "name": "Relaxin 3 receptor 1 binds relaxin 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318452", "species_10318460" ], "products": [ "species_10318462" ], "modifiers": [], "additional_components": [ "ENSXETT00000037509", "B1AAQ2", "ENSXETT00000062741", "B1AAQ2", "ENSXETT00000062741", "F7E376", "ENSXETT00000037509" ] }, "reaction_10318480": { "compartment": "compartment_984", "id": "reaction_10318480", "reactome": "R-XTR-444859", "name": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318466", "species_10318476" ], "products": [ "species_10318478" ], "modifiers": [], "additional_components": [ "ENSXETT00000037509", "B1AAQ2", "ENSXETT00000062741", "A0A6I8SQK1", "ENSXETG00000036496", "B1AAQ2", "ENSXETT00000062741", "A0A6I8SQK1", "ENSXETG00000036496", "F7E376", "ENSXETT00000037509" ] }, "reaction_10317344": { "compartment": "compartment_984", "id": "reaction_10317344", "reactome": "R-XTR-389487", "name": "Orexin 2 receptor can bind orexin-B neuropeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317336", "species_10317340" ], "products": [ "species_10317342" ], "modifiers": [], "additional_components": [ "ENSXETG00000036925", "ENSXETT00000034321", "F6UHP0", "ENSXETT00000034321", "A0A6I8RRB4", "ENSXETG00000036925" ] }, "reaction_10316962": { "compartment": "compartment_984", "id": "reaction_10316962", "reactome": "R-XTR-374173", "name": "AGT(34-41) binds to AGTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316946", "species_10316956" ], "products": [ "species_10316958" ], "modifiers": [ [ "species_10316960", "inhibitor" ] ], "additional_components": [ "ENSXETT00000023026", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "B3DLC0", "ENSXETT00000023026", "B3DLC0", "ENSXETT00000023026" ] }, "reaction_10320722": { "compartment": "compartment_876", "id": "reaction_10320722", "reactome": "R-XTR-947673", "name": "Melanin-concentrating hormone receptors bind MCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10319136", "species_10319140" ], "products": [ "species_10319142" ], "modifiers": [], "additional_components": [ "ENSXETT00000065305", "ENSXETG00000030934", "A0A6I8PX40", "ENSXETG00000030934", "F6YI59", "ENSXETT00000065305" ] }, "reaction_10317817": { "compartment": "compartment_984", "id": "reaction_10317817", "reactome": "R-XTR-419428", "name": "S1PR2-5 bind S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_10317813" ], "products": [ "species_10317815" ], "modifiers": [], "additional_components": [ "A0A6I8PRW9", "ENSXETG00000033700", "B1WAQ2", "ENSXETT00000070659", "A0A6I8PRW9", "ENSXETG00000033700", "B1WAQ2", "ENSXETT00000070659", "species_428203" ] }, "reaction_10317803": { "compartment": "compartment_984", "id": "reaction_10317803", "reactome": "R-XTR-419389", "name": "LPA-binding receptors bind LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317799", "species_417891" ], "products": [ "species_10317801" ], "modifiers": [], "additional_components": [ "ENSXETG00000039332", "species_417891", "A0A6I8RG49", "ENSXETG00000039332" ] }, "reaction_10318412": { "compartment": "compartment_984", "id": "reaction_10318412", "reactome": "R-XTR-444661", "name": "HCAR2 binds HCAR2 ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318408", "species_3296262" ], "products": [ "species_10318410" ], "modifiers": [], "additional_components": [ "ENSXETG00000033184", "CHEBI:20067", "CHEBI:15940", "CHEBI:20067", "CHEBI:15940", "A0A6I8PVP2", "ENSXETG00000033184" ] }, "reaction_10317756": { "compartment": "compartment_984", "id": "reaction_10317756", "reactome": "R-XTR-418918", "name": "The UDP/CysLT (P2Y17) receptor can bind UTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_417888", "species_10317614" ], "products": [ "species_10317754" ], "modifiers": [], "additional_components": [ "ENSXETG00000030217", "A0A6I8Q294", "ENSXETG00000030217", "species_417888" ] }, "reaction_10317705": { "compartment": "compartment_984", "id": "reaction_10317705", "reactome": "R-XTR-417927", "name": "P2Y2 receptor binds ATP and UTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317701", "species_511955" ], "products": [ "species_10317703" ], "modifiers": [], "additional_components": [ "ENSXETG00000039207", "CHEBI:15713", "species_113593", "CHEBI:15713", "species_113593", "A0A6I8T2N1", "ENSXETG00000039207" ] }, "reaction_10317752": { "compartment": "compartment_984", "id": "reaction_10317752", "reactome": "R-XTR-418904", "name": "A1 and A3 receptors bind adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317746", "species_83908" ], "products": [ "species_10317750" ], "modifiers": [], "additional_components": [ "ENSXETG00000031634", "species_8857850", "A0A6I8QZP2", "ENSXETG00000031634" ] }, "reaction_10327569": { "compartment": "compartment_876", "id": "reaction_10327569", "reactome": "R-XTR-3296309", "name": "HCAR3 binds HCAR3 ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320048", "species_3296330" ], "products": [ "species_10320050" ], "modifiers": [], "additional_components": [ "ENSXETG00000033184", "CHEBI:37098", "CHEBI:15940", "CHEBI:37098", "CHEBI:15940", "A0A6I8PVP2", "ENSXETG00000033184" ] }, "reaction_10327571": { "compartment": "compartment_876", "id": "reaction_10327571", "reactome": "R-XTR-3296326", "name": "HCAR1 binds LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_373863", "species_10320044" ], "products": [ "species_10320046" ], "modifiers": [], "additional_components": [ "ENSXETG00000033184", "A0A6I8PVP2", "ENSXETG00000033184", "species_373863" ] }, "reaction_10327567": { "compartment": "compartment_876", "id": "reaction_10327567", "reactome": "R-XTR-3296304", "name": "GPR31 is a receptor for 12(S)-HETE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320086", "species_3296298" ], "products": [ "species_10320088" ], "modifiers": [], "additional_components": [ "ENSXETG00000033184", "species_3296298", "A0A6I8PVP2", "ENSXETG00000033184" ] }, "reaction_10318324": { "compartment": "compartment_984", "id": "reaction_10318324", "reactome": "R-XTR-444047", "name": "Receptor FFAR3 binds carboxylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318320", "species_444074" ], "products": [ "species_10318322" ], "modifiers": [], "additional_components": [ "ENSXETG00000034865", "species_29460", "CHEBI:31011", "species_76179", "species_29416", "CHEBI:30768", "species_29460", "CHEBI:31011", "species_76179", "species_29416", "CHEBI:30768", "A0A6I8RL92", "ENSXETG00000034865" ] }, "reaction_10318339": { "compartment": "compartment_984", "id": "reaction_10318339", "reactome": "R-XTR-444171", "name": "Receptor FFAR2 binds carboxylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444210", "species_10318335" ], "products": [ "species_10318337" ], "modifiers": [], "additional_components": [ "species_29460", "CHEBI:17120", "CHEBI:31011", "species_76179", "species_29416", "CHEBI:30768", "ENSXETG00000034865", "A0A6I8RL92", "ENSXETG00000034865", "species_29460", "CHEBI:17120", "CHEBI:31011", "species_76179", "species_29416", "CHEBI:30768" ] }, "reaction_10327559": { "compartment": "compartment_876", "id": "reaction_10327559", "reactome": "R-XTR-3296244", "name": "SUCNR1 binds SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433123", "species_10320040" ], "products": [ "species_10320042" ], "modifiers": [], "additional_components": [ "ENSXETG00000039349", "A0A6I8S407", "ENSXETG00000039349", "species_159939" ] }, "reaction_10318406": { "compartment": "compartment_984", "id": "reaction_10318406", "reactome": "R-XTR-444572", "name": "Zinc is an agonist of GPR39", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318402", "species_158417" ], "products": [ "species_10318404" ], "modifiers": [], "additional_components": [ "ENSXETG00000036628", "species_29426", "A0A6I8RPP0", "ENSXETG00000036628" ] }, "reaction_10318432": { "compartment": "compartment_984", "id": "reaction_10318432", "reactome": "R-XTR-444731", "name": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_10318428" ], "products": [ "species_10318430" ], "modifiers": [], "additional_components": [ "F7AA76", "ENSXETT00000034427", "A0A6I8QT77", "ENSXETG00000040511", "A0A6I8PUB9", "ENSXETG00000033328", "F7AA76", "ENSXETT00000034427", "A0A6I8QT77", "ENSXETG00000040511", "A0A6I8PUB9", "ENSXETG00000033328", "species_156540" ] }, "reaction_10317644": { "compartment": "compartment_984", "id": "reaction_10317644", "reactome": "R-XTR-391942", "name": "IP receptor can bind prostacyclin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317640", "species_391926" ], "products": [ "species_10317642" ], "modifiers": [], "additional_components": [ "ENSXETG00000031128", "species_31593", "A0A6I8PVP3", "ENSXETG00000031128" ] }, "reaction_10317610": { "compartment": "compartment_984", "id": "reaction_10317610", "reactome": "R-XTR-391934", "name": "DP2 receptor can bind PGD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317606", "species_416911" ], "products": [ "species_10317608" ], "modifiers": [], "additional_components": [ "A0A6I8PVU0", "ENSXETG00000035176", "A0A6I8QNA8", "ENSXETG00000036987", "A0A6I8QGG0", "ENSXETG00000035176", "species_416911", "A0A6I8PVU0", "ENSXETG00000035176", "A0A6I8QNA8", "ENSXETG00000036987", "A0A6I8QGG0", "ENSXETG00000035176" ] }, "reaction_10317697": { "compartment": "compartment_984", "id": "reaction_10317697", "reactome": "R-XTR-416929", "name": "FP receptor can bind PGF2-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_391928", "species_10317693" ], "products": [ "species_10317695" ], "modifiers": [], "additional_components": [ "ENSXETG00000036599", "A0A6I8S7J6", "ENSXETG00000036599", "species_391928" ] }, "reaction_10317588": { "compartment": "compartment_984", "id": "reaction_10317588", "reactome": "R-XTR-391905", "name": "Oxoeicosanoid receptor can bind oxoeicosanoid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317584", "species_416428" ], "products": [ "species_10317586" ], "modifiers": [], "additional_components": [ "ENSXETG00000033184", "species_416428", "A0A6I8PVP2", "ENSXETG00000033184" ] }, "reaction_10317636": { "compartment": "compartment_984", "id": "reaction_10317636", "reactome": "R-XTR-391941", "name": "BLT receptors can bind LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317632", "species_416436" ], "products": [ "species_10317634" ], "modifiers": [], "additional_components": [ "F7B9R6", "ENSXETT00000038060", "A0A6I8S269", "ENSXETG00000036845", "species_416436", "F7B9R6", "ENSXETT00000038060", "A0A6I8S269", "ENSXETG00000036845" ] }, "reaction_10317618": { "compartment": "compartment_984", "id": "reaction_10317618", "reactome": "R-XTR-391937", "name": "UDP/CysLT receptor can bind cysteinyl leukotrienes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317614", "species_416372" ], "products": [ "species_10317616" ], "modifiers": [], "additional_components": [ "ENSXETG00000030217", "CHEBI:28666", "CHEBI:16978", "CHEBI:15650", "CHEBI:28666", "CHEBI:16978", "CHEBI:15650", "A0A6I8Q294", "ENSXETG00000030217" ] }, "reaction_10317742": { "compartment": "compartment_876", "id": "reaction_10317742", "reactome": "R-XTR-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312731" ], "products": [ "species_10317739" ], "modifiers": [ [ "species_10312731", "catalyst" ] ], "additional_components": [ "B1H2U7", "ENSXETT00000094272", "species_29438", "species_29420", "B1H2U7", "ENSXETT00000094272", "B1H2U7", "ENSXETT00000094272", "species_29438" ] }, "reaction_10317795": { "compartment": "compartment_70101", "id": "reaction_10317795", "reactome": "R-XTR-419166", "name": "GEFs activate RhoA,B,C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10317687" ], "products": [ "species_29420", "species_10317689" ], "modifiers": [ [ "species_10316070", "catalyst" ] ], "additional_components": [ "species_29420", "Q6NVL3", "ENSXETT00000056231", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8QGS5", "ENSXETG00000038787", "F7DKF6", "ENSXETT00000044021", "A4II46", "ENSXETT00000074782", "A0A6I8Q734", "ENSXETG00000009131", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10312776": { "compartment": "compartment_114521", "id": "reaction_10312776", "reactome": "R-XTR-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10312773", "catalyst" ] ], "additional_components": [ "species_114520", "species_74112", "A0A6I8QV43", "ENSXETG00000005153", "F6XEN8", "ENSXETT00000003958" ] }, "reaction_10317957": { "compartment": "compartment_70101", "id": "reaction_10317957", "reactome": "R-XTR-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_76108", "species_29370" ], "modifiers": [ [ "species_10317954", "catalyst" ] ], "additional_components": [ "A0A6I8SXY7", "ENSXETG00000014560", "A0A6I8SPG5", "ENSXETG00000005053", "F7DCA2", "ENSXETT00000006488" ] }, "reaction_10312816": { "compartment": "compartment_70101", "id": "reaction_10312816", "reactome": "R-XTR-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312771", "species_114520" ], "products": [ "species_10312773" ], "modifiers": [], "additional_components": [ "A0A6I8QV43", "ENSXETG00000005153", "F6XEN8", "ENSXETT00000003958", "species_114520", "species_74112", "A0A6I8QV43", "ENSXETG00000005153", "F6XEN8", "ENSXETT00000003958" ] }, "reaction_10331377": { "compartment": "compartment_876", "id": "reaction_10331377", "reactome": "R-XTR-5694462", "name": "ABHD6,12 hydrolyse 3AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694509" ], "products": [ "species_422506", "species_70106", "species_76116" ], "modifiers": [ [ "species_10331374", "catalyst" ] ], "additional_components": [ "ENSXETG00000012789" ] }, "reaction_10326350": { "compartment": "compartment_70101", "id": "reaction_10326350", "reactome": "R-XTR-2179415", "name": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312049", "species_10326342" ], "products": [ "species_10326348" ], "modifiers": [], "additional_components": [ "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387", "A0A6I8QCY1", "ENSXETG00000039798", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "F7C8B9", "ENSXETT00000006761", "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10326344": { "compartment": "compartment_984", "id": "reaction_10326344", "reactome": "R-XTR-2179387", "name": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313820", "species_10313836" ], "products": [ "species_10326342" ], "modifiers": [], "additional_components": [ "ENSXETT00000006761", "ENSXETG00000039798", "A0A6I8QCY1", "ENSXETG00000039798", "F7C8B9", "ENSXETT00000006761" ] }, "reaction_10320122": { "compartment": "compartment_984", "id": "reaction_10320122", "reactome": "R-XTR-870269", "name": "Gastrin binds to CCK-B receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10319126", "species_10319130" ], "products": [ "species_10319132" ], "modifiers": [], "additional_components": [ "ENSXETT00000050945", "ENSXETT00000027311", "F6W277", "ENSXETT00000027311", "F6ZEU0", "ENSXETT00000050945" ] }, "reaction_10317737": { "compartment": "compartment_70101", "id": "reaction_10317737", "reactome": "R-XTR-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10317734", "catalyst" ] ], "additional_components": [ "F6T8H7", "ENSXETT00000040889", "A0A6I8SHT5", "ENSXETG00000011637" ] }, "reaction_10338257": { "compartment": "compartment_70101", "id": "reaction_10338257", "reactome": "R-XTR-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10312595", "catalyst" ] ], "additional_components": [ "ENSXETG00000011637" ] }, "reaction_10337052": { "compartment": "compartment_876", "id": "reaction_10337052", "reactome": "R-XTR-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337050" ], "products": [ "species_10320096", "species_10337048" ], "modifiers": [], "additional_components": [ "F7ANT3", "ENSXETT00000036860", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236", "species_29420", "F7ANT3", "ENSXETT00000036860", "species_29420", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236" ] }, "reaction_10312560": { "compartment": "compartment_70101", "id": "reaction_10312560", "reactome": "R-XTR-111881", "name": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_10312556", "species_74016" ], "products": [ "species_10312558" ], "modifiers": [], "additional_components": [ "ENSXETT00000066288", "B1WAZ6", "ENSXETT00000066288", "species_74112", "species_426925" ] }, "reaction_10312598": { "compartment": "compartment_70101", "id": "reaction_10312598", "reactome": "R-XTR-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10312595", "catalyst" ] ], "additional_components": [ "ENSXETG00000011637" ] }, "reaction_10337061": { "compartment": "compartment_876", "id": "reaction_10337061", "reactome": "R-XTR-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337056" ], "products": [ "species_29372", "species_10337050" ], "modifiers": [ [ "species_10337056", "catalyst" ] ], "additional_components": [ "F7ANT3", "ENSXETT00000036860", "species_29438", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236", "F7ANT3", "ENSXETT00000036860", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236", "species_29420", "F7ANT3", "ENSXETT00000036860", "species_29438", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236" ] }, "reaction_10337058": { "compartment": "compartment_876", "id": "reaction_10337058", "reactome": "R-XTR-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337048", "species_10337054" ], "products": [ "species_10337056" ], "modifiers": [], "additional_components": [ "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236", "F7ANT3", "ENSXETT00000036860", "species_29438", "F7ANT3", "ENSXETT00000036860", "species_29438", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236" ] }, "reaction_10318153": { "compartment": "compartment_876", "id": "reaction_10318153", "reactome": "R-XTR-432067", "name": "Aquaporin-4 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10318150", "catalyst" ] ], "additional_components": [ "A0A6I8PZD7", "ENSXETG00000033655" ] }, "reaction_10318981": { "compartment": "compartment_876", "id": "reaction_10318981", "reactome": "R-XTR-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10318974", "catalyst" ] ], "additional_components": [ "A0A6I8Q4T0", "ENSXETG00000002150", "A0A6I8PZD7", "ENSXETG00000033655" ] }, "reaction_10318983": { "compartment": "compartment_876", "id": "reaction_10318983", "reactome": "R-XTR-507871", "name": "Aquaporins passively transport glycerol out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10318159", "catalyst" ] ], "additional_components": [ "A0A6I8Q4T0", "ENSXETG00000002150" ] }, "reaction_10318977": { "compartment": "compartment_876", "id": "reaction_10318977", "reactome": "R-XTR-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10318974", "catalyst" ] ], "additional_components": [ "A0A6I8Q4T0", "ENSXETG00000002150", "A0A6I8PZD7", "ENSXETG00000033655" ] }, "reaction_10318979": { "compartment": "compartment_876", "id": "reaction_10318979", "reactome": "R-XTR-507869", "name": "Aquaporins passively transport glycerol into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192438" ], "products": [ "species_76116" ], "modifiers": [ [ "species_10318159", "catalyst" ] ], "additional_components": [ "A0A6I8Q4T0", "ENSXETG00000002150" ] }, "reaction_10318162": { "compartment": "compartment_876", "id": "reaction_10318162", "reactome": "R-XTR-432074", "name": "Aquaporin-7 passively transports glycerol out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10318159", "catalyst" ] ], "additional_components": [ "A0A6I8Q4T0", "ENSXETG00000002150" ] }, "reaction_10336143": { "compartment": "compartment_7660", "id": "reaction_10336143", "reactome": "R-XTR-8936584", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336130", "species_77087" ], "products": [ "species_77502", "species_10336140" ], "modifiers": [ [ "species_10336130", "catalyst" ] ], "additional_components": [ "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10336152": { "compartment": "compartment_7660", "id": "reaction_10336152", "reactome": "R-XTR-8936608", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10336147" ], "products": [ "species_77502", "species_10336149" ], "modifiers": [ [ "species_10336147", "catalyst" ] ], "additional_components": [ "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10336170": { "compartment": "compartment_7660", "id": "reaction_10336170", "reactome": "R-XTR-8937113", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10336165" ], "products": [ "species_77502", "species_10336167" ], "modifiers": [ [ "species_10336165", "catalyst" ] ], "additional_components": [ "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10336161": { "compartment": "compartment_7660", "id": "reaction_10336161", "reactome": "R-XTR-8937022", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10336156" ], "products": [ "species_77502", "species_10336158" ], "modifiers": [ [ "species_10336156", "catalyst" ] ], "additional_components": [ "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10326663": { "compartment": "compartment_70101", "id": "reaction_10326663", "reactome": "R-XTR-2316434", "name": "PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10326660", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "A0A6I8RUB1", "ENSXETG00000007252", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "species_179838", "A0A6I8RAF1", "ENSXETG00000039550", "A0A6I8Q186", "ENSXETG00000012933" ] }, "reaction_10316685": { "compartment": "compartment_70101", "id": "reaction_10316685", "reactome": "R-XTR-350319", "name": "Caspase mediated cleavage of vimentin at IDVD (259)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315647" ], "products": [ "species_10316674", "species_10316672" ], "modifiers": [ [ "species_10316682", "catalyst" ] ], "additional_components": [ "ENSXETG00000007462", "ENSXETG00000007462", "ENSXETG00000007462", "A0A6I8Q0P2", "ENSXETG00000032748" ] }, "reaction_10315899": { "compartment": "compartment_70101", "id": "reaction_10315899", "reactome": "R-XTR-202967", "name": "Caspase mediated cleavage of alpha-II-Fodrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315893" ], "products": [ "species_10315895", "species_10315897" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000012869", "ENSXETG00000012869", "ENSXETG00000012869", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10315654": { "compartment": "compartment_70101", "id": "reaction_10315654", "reactome": "R-XTR-201628", "name": "Caspase-mediated cleavage of vimentin at DSVD (85)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315647" ], "products": [ "species_10315651", "species_10315649" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000007462", "ENSXETG00000007462", "ENSXETG00000007462", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10315889": { "compartment": "compartment_70101", "id": "reaction_10315889", "reactome": "R-XTR-202966", "name": "Caspase mediated cleavage of HIP-55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315883" ], "products": [ "species_10315887", "species_10315885" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000019013", "ENSXETG00000019013", "ENSXETG00000019013", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10315664": { "compartment": "compartment_70101", "id": "reaction_10315664", "reactome": "R-XTR-201629", "name": "Caspase-mediated cleavage of Tau", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315658" ], "products": [ "species_10315662", "species_10315660" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000001624", "ENSXETG00000001624", "ENSXETG00000001624", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10322285": { "compartment": "compartment_70101", "id": "reaction_10322285", "reactome": "R-XTR-1247668", "name": "Hemoglobin A binds O2, releasing H+ and CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_10322281" ], "products": [ "species_70106", "species_113528", "species_10322261" ], "modifiers": [], "additional_components": [ "species_189444", "P07428", "ENSXETT00000002494", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494", "species_113533", "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566" ] }, "reaction_10322216": { "compartment": "compartment_984", "id": "reaction_10322216", "reactome": "R-XTR-1237059", "name": "CA4:Zn2+ dehydrates HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10322211", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8QID1", "ENSXETG00000034545" ] }, "reaction_10314265": { "compartment": "compartment_13231", "id": "reaction_10314265", "reactome": "R-XTR-193691", "name": "NF-kB migrates to the nucleus and turns on transcription", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313343" ], "products": [ "species_10313349" ], "modifiers": [], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173" ] }, "reaction_10318346": { "compartment": "compartment_876", "id": "reaction_10318346", "reactome": "R-XTR-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10318343", "catalyst" ] ], "additional_components": [ "ENSXETG00000017762" ] }, "reaction_10318353": { "compartment": "compartment_876", "id": "reaction_10318353", "reactome": "R-XTR-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10318350", "catalyst" ] ], "additional_components": [ "ENSXETG00000019898" ] }, "reaction_10318497": { "compartment": "compartment_876", "id": "reaction_10318497", "reactome": "R-XTR-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10318343", "catalyst" ] ], "additional_components": [ "ENSXETG00000017762" ] }, "reaction_10318499": { "compartment": "compartment_876", "id": "reaction_10318499", "reactome": "R-XTR-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10318350", "catalyst" ] ], "additional_components": [ "ENSXETG00000019898" ] }, "reaction_10328233": { "compartment": "compartment_7660", "id": "reaction_10328233", "reactome": "R-XTR-3782655", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10328125" ], "products": [ "species_10328131", "species_5566518" ], "modifiers": [ [ "species_10328230", "catalyst" ] ], "additional_components": [ "A0A6I8RKR7", "ENSXETG00000035354", "ENSXETG00000031474" ] }, "reaction_10328226": { "compartment": "compartment_7660", "id": "reaction_10328226", "reactome": "R-XTR-3782637", "name": "HDAC8 deacetylates histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10328125" ], "products": [ "species_10328131", "species_5566518" ], "modifiers": [ [ "species_10328223", "catalyst" ] ], "additional_components": [ "A0A6I8RKR7", "ENSXETG00000035354", "ENSXETT00000044353" ] }, "reaction_10317294": { "compartment": "compartment_984", "id": "reaction_10317294", "reactome": "R-XTR-383313", "name": "Glucagon-like Peptide 1 is secreted from intestinal L cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317286" ], "products": [ "species_10317231" ], "modifiers": [ [ "species_10317292", "catalyst" ], [ "species_70115", "catalyst" ], [ "species_372533", "catalyst" ], [ "species_10317040", "catalyst" ] ], "additional_components": [ "ENSXETT00000028848", "ENSXETT00000028848", "ENSXETG00000038809", "ENSXETT00000045737" ] }, "reaction_10317907": { "compartment": "compartment_17957", "id": "reaction_10317907", "reactome": "R-XTR-421416", "name": "Proglucagon translocates from the ER Lumen to secretory granules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317903" ], "products": [ "species_10317905" ], "modifiers": [], "additional_components": [ "ENSXETT00000028848", "ENSXETT00000028848" ] }, "reaction_10317913": { "compartment": "compartment_17957", "id": "reaction_10317913", "reactome": "R-XTR-421426", "name": "ProGIP translocates from the ER Lumen to secretory granules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317909" ], "products": [ "species_10317911" ], "modifiers": [], "additional_components": [ "ENSXETT00000062069", "ENSXETT00000062069" ] }, "reaction_10317675": { "compartment": "compartment_984", "id": "reaction_10317675", "reactome": "R-XTR-400509", "name": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317671" ], "products": [ "species_10317673" ], "modifiers": [], "additional_components": [ "ENSXETT00000062069", "ENSXETT00000062069" ] }, "reaction_10313060": { "compartment": "compartment_20699", "id": "reaction_10313060", "reactome": "R-XTR-159796", "name": "Furin cleaves pro-factor IX to factor IX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313049" ], "products": [ "species_10313051", "species_10313053" ], "modifiers": [ [ "species_10313057", "catalyst" ] ], "additional_components": [ "ENSXETT00000025939", "ENSXETT00000025939", "ENSXETT00000025939", "ENSXETG00000015462" ] }, "reaction_10334519": { "compartment": "compartment_20699", "id": "reaction_10334519", "reactome": "R-XTR-6807224", "name": "Furin cleaves pro-BGLAP to BGLAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334513" ], "products": [ "species_10334515", "species_10334517" ], "modifiers": [ [ "species_10313057", "catalyst" ] ], "additional_components": [ "ENSXETT00000005554", "ENSXETT00000005554", "ENSXETT00000005554", "ENSXETG00000015462" ] }, "reaction_10313171": { "compartment": "compartment_20699", "id": "reaction_10313171", "reactome": "R-XTR-163798", "name": "Furin cleaves pro-protein Z to protein Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313165" ], "products": [ "species_10313169", "species_10313167" ], "modifiers": [ [ "species_10313057", "catalyst" ] ], "additional_components": [ "ENSXETT00000025939", "ENSXETT00000025939", "ENSXETT00000025939", "ENSXETG00000015462" ] }, "reaction_10322355": { "compartment": "compartment_876", "id": "reaction_10322355", "reactome": "R-XTR-1296046", "name": "KCNJs transport K+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126" ], "products": [ "species_29804" ], "modifiers": [ [ "species_10322352", "catalyst" ] ], "additional_components": [ "Q0IJ30", "ENSXETT00000049657" ] }, "reaction_10315917": { "compartment": "compartment_70101", "id": "reaction_10315917", "reactome": "R-XTR-203070", "name": "Association of profilin with monomeric actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315905", "species_10315913" ], "products": [ "species_10315915" ], "modifiers": [], "additional_components": [ "Q6P378", "ENSXETT00000057558", "species_113593", "Q6P378", "ENSXETT00000057558", "species_113593" ] }, "reaction_10328317": { "compartment": "compartment_70101", "id": "reaction_10328317", "reactome": "R-XTR-3858489", "name": "ppDVL binds DAAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328291", "species_10328313" ], "products": [ "species_10328315" ], "modifiers": [], "additional_components": [ "Q05AS8", "ENSXETG00000017212", "ENSXETG00000017030", "A0A6I8SJ25", "ENSXETG00000017030", "Q05AS8", "ENSXETG00000017212" ] }, "reaction_10330409": { "compartment": "compartment_70101", "id": "reaction_10330409", "reactome": "R-XTR-5666070", "name": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330405", "species_10330399" ], "products": [ "species_10330407" ], "modifiers": [], "additional_components": [ "A0A6I8RD71", "ENSXETG00000018144", "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8RD71", "ENSXETG00000018144" ] }, "reaction_10329929": { "compartment": "compartment_876", "id": "reaction_10329929", "reactome": "R-XTR-5623622", "name": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329921", "species_10329925" ], "products": [ "species_10329927" ], "modifiers": [], "additional_components": [ "A0A6I8R6D3", "ENSXETG00000006092", "A0A6I8PK39", "ENSXETG00000039434", "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8R6D3", "ENSXETG00000006092", "A0A6I8PK39", "ENSXETG00000039434" ] }, "reaction_10329945": { "compartment": "compartment_7660", "id": "reaction_10329945", "reactome": "R-XTR-5625717", "name": "Phosphorylated PKN1 binds androgen receptor (AR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329937", "species_10329941" ], "products": [ "species_10329943" ], "modifiers": [], "additional_components": [ "ENSXETG00000039434", "species_30321", "CHEBI:16422", "species_469662", "CHEBI:29117", "A0A6I8RK73", "ENSXETG00000005089", "species_30321", "CHEBI:16422", "species_469662", "CHEBI:29117", "A0A6I8RK73", "ENSXETG00000005089", "A0A6I8PK39", "ENSXETG00000039434" ] }, "reaction_10329961": { "compartment": "compartment_7660", "id": "reaction_10329961", "reactome": "R-XTR-5625745", "name": "PKN1 stimulates association of AR with NCOA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329957", "species_10329951" ], "products": [ "species_10329959" ], "modifiers": [], "additional_components": [ "ENSXETG00000015926", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "B5DE09", "ENSXETG00000015926" ] }, "reaction_10329973": { "compartment": "compartment_7660", "id": "reaction_10329973", "reactome": "R-XTR-5625774", "name": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329969", "species_10329951" ], "products": [ "species_10329971" ], "modifiers": [], "additional_components": [ "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10330023": { "compartment": "compartment_7660", "id": "reaction_10330023", "reactome": "R-XTR-5625848", "name": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10330008", "species_113685" ], "products": [ "species_10330020", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10330008", "catalyst" ] ], "additional_components": [ "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803" ] }, "reaction_10329990": { "compartment": "compartment_7660", "id": "reaction_10329990", "reactome": "R-XTR-5625784", "name": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10329971" ], "products": [ "species_113582", "species_10329987" ], "modifiers": [ [ "species_10329971", "catalyst" ] ], "additional_components": [ "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10329953": { "compartment": "compartment_70101", "id": "reaction_10329953", "reactome": "R-XTR-5625738", "name": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329943" ], "products": [ "species_10329951" ], "modifiers": [], "additional_components": [ "species_30321", "CHEBI:16422", "species_469662", "CHEBI:29117", "A0A6I8RK73", "ENSXETG00000005089", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434" ] }, "reaction_10330047": { "compartment": "compartment_70101", "id": "reaction_10330047", "reactome": "R-XTR-5626507", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330039", "species_10330043" ], "products": [ "species_10330045" ], "modifiers": [], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8S827", "ENSXETG00000020384", "Q6P378", "ENSXETT00000057558", "species_113593", "Q6P378", "ENSXETT00000057558", "species_113593", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8S827", "ENSXETG00000020384" ] }, "reaction_10330041": { "compartment": "compartment_70101", "id": "reaction_10330041", "reactome": "R-XTR-5626469", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330037", "species_10312717" ], "products": [ "species_10330039" ], "modifiers": [], "additional_components": [ "A0A6I8S827", "ENSXETG00000020384", "Q6GL60", "ENSXETT00000092508", "species_29438", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8S827", "ENSXETG00000020384" ] }, "reaction_10337088": { "compartment": "compartment_5460", "id": "reaction_10337088", "reactome": "R-XTR-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337081" ], "products": [], "modifiers": [ [ "species_10337085", "catalyst" ] ], "additional_components": [ "A0A6I8SHX8", "ENSXETG00000041384", "ENSXETG00000009818" ] }, "reaction_10329865": { "compartment": "compartment_24337", "id": "reaction_10329865", "reactome": "R-XTR-5610763", "name": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329855" ], "products": [ "species_10329859" ], "modifiers": [ [ "species_10329863", "inhibitor" ] ], "additional_components": [ "A0A6I8RRT2", "ENSXETG00000014939", "A0A6I8RRT2", "ENSXETG00000014939", "ENSXETG00000014834" ] }, "reaction_10329849": { "compartment": "compartment_876", "id": "reaction_10329849", "reactome": "R-XTR-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10329846", "catalyst" ] ], "additional_components": [ "species_109496" ] }, "reaction_10330636": { "compartment": "compartment_7660", "id": "reaction_10330636", "reactome": "R-XTR-5683831", "name": "CCDC59 binds TTF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330628", "species_10330632" ], "products": [ "species_10330634" ], "modifiers": [], "additional_components": [ "ENSXETT00000031815", "ENSXETG00000040672", "A0A6I8R1F2", "ENSXETG00000040672", "F6XAD1", "ENSXETT00000031815" ] }, "reaction_10330828": { "compartment": "compartment_876", "id": "reaction_10330828", "reactome": "R-XTR-5686286", "name": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330816" ], "products": [ "species_10330826" ], "modifiers": [], "additional_components": [ "A0A6I8SVN5", "ENSXETG00000009325", "F6ULZ5", "ENSXETT00000023447", "F6ULZ5", "ENSXETT00000023447", "A0A6I8SVN5", "ENSXETG00000009325" ] }, "reaction_10337007": { "compartment": "compartment_12045", "id": "reaction_10337007", "reactome": "R-XTR-8961021", "name": "SFTPD binds with itself to form SFTPD 12mer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337003" ], "products": [ "species_10337005" ], "modifiers": [], "additional_components": [ "A0A6I8R9D1", "ENSXETG00000034779", "A0A6I8R9D1", "ENSXETG00000034779" ] }, "reaction_10330798": { "compartment": "compartment_12045", "id": "reaction_10330798", "reactome": "R-XTR-5685649", "name": "SFTPAs translocate from ER membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330794" ], "products": [ "species_10330796" ], "modifiers": [], "additional_components": [ "A0A6I8SVN5", "ENSXETG00000009325", "A0A6I8SVN5", "ENSXETG00000009325" ] }, "reaction_10330830": { "compartment": "compartment_876", "id": "reaction_10330830", "reactome": "R-XTR-5686301", "name": "PALM-C100-CKAP4 binds SFTPAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330814", "species_10330796" ], "products": [ "species_10330816" ], "modifiers": [], "additional_components": [ "ENSXETT00000023447", "A0A6I8SVN5", "ENSXETG00000009325", "A0A6I8SVN5", "ENSXETG00000009325", "F6ULZ5", "ENSXETT00000023447" ] }, "reaction_10330809": { "compartment": "compartment_3828046", "id": "reaction_10330809", "reactome": "R-XTR-5685902", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5685882", "species_10330697" ], "products": [ "species_10330802", "species_10330800" ], "modifiers": [ [ "species_10330806", "catalyst" ] ], "additional_components": [ "ENSXETG00000031314", "ENSXETG00000031314", "ENSXETG00000031314", "ENSXETT00000003012" ] }, "reaction_10331288": { "compartment": "compartment_984", "id": "reaction_10331288", "reactome": "R-XTR-5693346", "name": "CECRI deaminates Ade-Rib to Ino", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_83908" ], "products": [ "species_2022135", "species_83921" ], "modifiers": [ [ "species_10331285", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8QUN5", "ENSXETG00000039169" ] }, "reaction_10330699": { "compartment": "compartment_12045", "id": "reaction_10330699", "reactome": "R-XTR-5684868", "name": "pro-SFTPC translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330695" ], "products": [ "species_10330697" ], "modifiers": [], "additional_components": [ "ENSXETG00000031314", "ENSXETG00000031314" ] }, "reaction_10337812": { "compartment": "compartment_12045", "id": "reaction_10337812", "reactome": "R-XTR-9624778", "name": "SFTPD 12mer translocates from ER membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337005" ], "products": [ "species_10337810" ], "modifiers": [], "additional_components": [ "A0A6I8R9D1", "ENSXETG00000034779", "A0A6I8R9D1", "ENSXETG00000034779" ] }, "reaction_10336078": { "compartment": "compartment_70101", "id": "reaction_10336078", "reactome": "R-XTR-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336068", "species_71284" ], "products": [ "species_10336071", "species_71285" ], "modifiers": [ [ "species_10336075", "catalyst" ] ], "additional_components": [ "ENSXETT00000067185", "ENSXETT00000067185", "ENSXETG00000037439" ] }, "reaction_10336088": { "compartment": "compartment_70101", "id": "reaction_10336088", "reactome": "R-XTR-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312906", "species_71284" ], "products": [ "species_10336081", "species_71285" ], "modifiers": [ [ "species_10336085", "catalyst" ] ], "additional_components": [ "ENSXETG00000037123", "ENSXETG00000037123", "ENSXETG00000030721" ] }, "reaction_10336059": { "compartment": "compartment_70101", "id": "reaction_10336059", "reactome": "R-XTR-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312906", "species_71284" ], "products": [ "species_10336052", "species_71285" ], "modifiers": [ [ "species_10336056", "catalyst" ] ], "additional_components": [ "ENSXETG00000037123", "ENSXETG00000037123", "ENSXETG00000033485" ] }, "reaction_10313177": { "compartment": "compartment_13959", "id": "reaction_10313177", "reactome": "R-XTR-163825", "name": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313175" ], "products": [ "species_10313165" ], "modifiers": [], "additional_components": [ "ENSXETT00000025939", "ENSXETT00000025939" ] }, "reaction_10334521": { "compartment": "compartment_13959", "id": "reaction_10334521", "reactome": "R-XTR-6807229", "name": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334511" ], "products": [ "species_10334513" ], "modifiers": [], "additional_components": [ "ENSXETT00000005554", "ENSXETT00000005554" ] }, "reaction_10313066": { "compartment": "compartment_13959", "id": "reaction_10313066", "reactome": "R-XTR-159836", "name": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313064" ], "products": [ "species_10313049" ], "modifiers": [], "additional_components": [ "ENSXETT00000025939", "ENSXETT00000025939" ] }, "reaction_10316020": { "compartment": "compartment_70101", "id": "reaction_10316020", "reactome": "R-XTR-204617", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_10316005", "species_204628", "species_73473" ], "products": [ "species_204635", "species_10316009", "species_29360" ], "modifiers": [ [ "species_10316017", "catalyst" ] ], "additional_components": [ "ENSXETG00000034500", "ENSXETG00000034500", "F6RYK2", "ENSXETT00000012343" ] }, "reaction_10316036": { "compartment": "compartment_70101", "id": "reaction_10316036", "reactome": "R-XTR-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_10316005", "species_29368", "species_73473" ], "products": [ "species_29356", "species_10316025", "species_29360" ], "modifiers": [ [ "species_10316033", "catalyst" ] ], "additional_components": [ "ENSXETG00000034500", "ENSXETG00000034500", "A0A6I8SV44", "ENSXETG00000040489", "species_435347" ] }, "reaction_10338051": { "compartment": "compartment_17963", "id": "reaction_10338051", "reactome": "R-XTR-9668023", "name": "TPST1,2 transfer SO4(2-) from PAPS to FVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10338041" ], "products": [ "species_10338049", "species_742343" ], "modifiers": [ [ "species_10336936", "catalyst" ] ], "additional_components": [ "ENSXETG00000038196", "ENSXETG00000038196", "ENSXETG00000017664" ] }, "reaction_10321802": { "compartment": "compartment_70101", "id": "reaction_10321802", "reactome": "R-XTR-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321798" ], "products": [ "species_10321800" ], "modifiers": [], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "CHEBI:60627", "CHEBI:60628", "CHEBI:59092", "CHEBI:60629", "CHEBI:59087", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858" ] }, "reaction_10335136": { "compartment": "compartment_70101", "id": "reaction_10335136", "reactome": "R-XTR-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10321800" ], "products": [ "species_8853371", "species_8853381" ], "modifiers": [ [ "species_10335133", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "CHEBI:59092", "CHEBI:60629", "CHEBI:59087", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "CHEBI:91280", "CHEBI:91284", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "ENSXETT00000043623" ] }, "reaction_10328409": { "compartment": "compartment_17963", "id": "reaction_10328409", "reactome": "R-XTR-4084984", "name": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_4086285" ], "products": [ "species_4086277", "species_727810" ], "modifiers": [ [ "species_10325929", "catalyst" ] ], "additional_components": [ "ENSXETG00000026104" ] }, "reaction_10328407": { "compartment": "compartment_20699", "id": "reaction_10328407", "reactome": "R-XTR-4084978", "name": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_4088006" ], "products": [ "species_727810", "species_4087982" ], "modifiers": [ [ "species_10328404", "catalyst" ] ], "additional_components": [ "A0A6I8Q045", "ENSXETG00000024127", "A1KQY5", "ENSXETT00000075006", "Q6DNG6", "ENSXETG00000023481", "A0A6I8QSS5", "ENSXETG00000035254", "A0A6I8S6X4", "ENSXETG00000039548" ] }, "reaction_10328418": { "compartment": "compartment_70101", "id": "reaction_10328418", "reactome": "R-XTR-4085217", "name": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4088096" ], "products": [ "species_4088099", "species_29398" ], "modifiers": [ [ "species_10328415", "catalyst" ] ], "additional_components": [ "species_975925", "CHEBI:29025", "CHEBI:17122", "CHEBI:28255", "Q5M905", "ENSXETT00000033244" ] }, "reaction_10333998": { "compartment": "compartment_70101", "id": "reaction_10333998", "reactome": "R-XTR-6803771", "name": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803785", "species_113592" ], "products": [ "species_6803738", "species_70106", "species_29370" ], "modifiers": [ [ "species_10333995", "catalyst" ] ], "additional_components": [ "CHEBI:27459", "species_1678743", "CHEBI:15784", "CHEBI:88130", "A0A5K1VLH5", "ENSXETT00000012241" ] }, "reaction_10318563": { "compartment": "compartment_70101", "id": "reaction_10318563", "reactome": "R-XTR-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512", "species_29472" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10318560", "catalyst" ] ], "additional_components": [ "ENSXETT00000029938" ] }, "reaction_10319089": { "compartment": "compartment_20699", "id": "reaction_10319089", "reactome": "R-XTR-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10319086", "catalyst" ] ], "additional_components": [ "ENSXETG00000036219" ] }, "reaction_10332336": { "compartment": "compartment_70101", "id": "reaction_10332336", "reactome": "R-XTR-6787540", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6787678" ], "products": [ "species_29370", "species_6787542" ], "modifiers": [ [ "species_10332333", "catalyst" ] ], "additional_components": [ "ENSXETG00000040982" ] }, "reaction_10320776": { "compartment": "compartment_20699", "id": "reaction_10320776", "reactome": "R-XTR-975916", "name": "Addition of GlcNAc to position 5 by MGAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981617" ], "modifiers": [ [ "species_10320773", "catalyst" ] ], "additional_components": [ "ENSXETG00000000514" ] }, "reaction_10321819": { "compartment": "compartment_20699", "id": "reaction_10321819", "reactome": "R-XTR-1022133", "name": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975925", "species_975910" ], "products": [ "species_981615" ], "modifiers": [ [ "species_10321816", "catalyst" ] ], "additional_components": [ "A0A6I8Q045", "ENSXETG00000024127", "A0A6I8QSS5", "ENSXETG00000035254", "Q6DNG6", "ENSXETG00000023481" ] }, "reaction_10320769": { "compartment": "compartment_20699", "id": "reaction_10320769", "reactome": "R-XTR-975903", "name": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981616" ], "modifiers": [ [ "species_10320766", "catalyst" ] ], "additional_components": [ "ENSXETG00000019401" ] }, "reaction_10320785": { "compartment": "compartment_20699", "id": "reaction_10320785", "reactome": "R-XTR-975919", "name": "Addition of galactose by beta 4-galactosyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_975910" ], "products": [ "species_981618" ], "modifiers": [ [ "species_10320782", "catalyst" ] ], "additional_components": [ "A0A6I8QS90", "ENSXETG00000034513" ] }, "reaction_10320729": { "compartment": "compartment_17963", "id": "reaction_10320729", "reactome": "R-XTR-964759", "name": "Alternative endo-mannosidase I route", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964754" ], "products": [ "species_964744", "species_964746" ], "modifiers": [ [ "species_10320726", "catalyst" ] ], "additional_components": [ "ENSXETG00000038826" ] }, "reaction_10335243": { "compartment": "compartment_984", "id": "reaction_10335243", "reactome": "R-XTR-8855711", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855720", "species_10335239" ], "products": [ "species_10335241" ], "modifiers": [], "additional_components": [ "A0A6I8Q6M7", "ENSXETG00000041320", "A0A6I8Q6M7", "ENSXETG00000041320", "species_8855720" ] }, "reaction_10335258": { "compartment": "compartment_20699", "id": "reaction_10335258", "reactome": "R-XTR-8855954", "name": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335248", "species_735682" ], "products": [ "species_10335251", "species_205687" ], "modifiers": [ [ "species_10335255", "catalyst" ] ], "additional_components": [ "ENSXETG00000037485", "ENSXETG00000037485", "ENSXETG00000033376" ] }, "reaction_10335149": { "compartment": "compartment_70101", "id": "reaction_10335149", "reactome": "R-XTR-8853529", "name": "OTULIN,USP5 cleaves UBB yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335147" ], "products": [ "species_10312090", "species_10312094", "species_10312092" ], "modifiers": [ [ "species_10335142", "catalyst" ] ], "additional_components": [ "ENSXETG00000037858", "ENSXETG00000037858", "ENSXETG00000037858", "ENSXETG00000037858", "ENSXETT00000003610" ] }, "reaction_10335145": { "compartment": "compartment_70101", "id": "reaction_10335145", "reactome": "R-XTR-8853515", "name": "OTULIN,USP5 cleaves UBC yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335138" ], "products": [ "species_10312114", "species_10312098", "species_10312112", "species_10312102", "species_10312100", "species_10312106", "species_10312104", "species_10312110", "species_10312108" ], "modifiers": [ [ "species_10335142", "catalyst" ] ], "additional_components": [ "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETT00000003610" ] }, "reaction_10313091": { "compartment": "compartment_17957", "id": "reaction_10313091", "reactome": "R-XTR-162729", "name": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_10313078" ], "products": [ "species_1524021", "species_10313084" ], "modifiers": [ [ "species_10313088", "catalyst" ] ], "additional_components": [ "A0A6I8PQQ3", "ENSXETG00000033079", "A0A6I8SLF2", "ENSXETG00000037404", "A0A6I8PQQ3", "ENSXETG00000033079", "A0A6I8SLF2", "ENSXETG00000037404", "ENSXETG00000034065" ] }, "reaction_10313104": { "compartment": "compartment_12045", "id": "reaction_10313104", "reactome": "R-XTR-162742", "name": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855660" ], "products": [ "species_8855660" ], "modifiers": [ [ "species_10313101", "catalyst" ] ], "additional_components": [ "A0A6I8QRW2", "ENSXETG00000003720", "B7ZT49", "ENSXETT00000055317" ] }, "reaction_10313123": { "compartment": "compartment_70101", "id": "reaction_10313123", "reactome": "R-XTR-162857", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855657", "species_29356" ], "products": [ "species_8855661", "species_29416" ], "modifiers": [ [ "species_10313120", "catalyst" ] ], "additional_components": [ "ENSXETG00000038618" ] }, "reaction_10327110": { "compartment": "compartment_7660", "id": "reaction_10327110", "reactome": "R-XTR-2990833", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10327093", "species_10327097" ], "products": [ "species_10327107", "species_164121", "species_113541" ], "modifiers": [ [ "species_10327093", "catalyst" ] ], "additional_components": [ "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374", "ENSXETG00000022072", "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374", "Q6DEP7", "ENSXETG00000022072", "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374" ] }, "reaction_10327143": { "compartment": "compartment_7660", "id": "reaction_10327143", "reactome": "R-XTR-2993780", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327107", "species_10327128" ], "products": [ "species_10327136", "species_10327093" ], "modifiers": [ [ "species_10327093", "catalyst" ], [ "species_10327141", "catalyst" ] ], "additional_components": [ "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374", "Q6DEP7", "ENSXETG00000022072", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374", "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374", "ENSXETG00000025843" ] }, "reaction_10325469": { "compartment": "compartment_984", "id": "reaction_10325469", "reactome": "R-XTR-2022411", "name": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10325445" ], "products": [ "species_10316956" ], "modifiers": [ [ "species_10325464", "catalyst" ] ], "additional_components": [ "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "ENSXETT00000037000" ] }, "reaction_10325439": { "compartment": "compartment_984", "id": "reaction_10325439", "reactome": "R-XTR-2022368", "name": "Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325426", "species_109276" ], "products": [ "species_10325432" ], "modifiers": [ [ "species_10325436", "catalyst" ] ], "additional_components": [ "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "ENSXETG00000007771" ] }, "reaction_10325448": { "compartment": "compartment_984", "id": "reaction_10325448", "reactome": "R-XTR-2022383", "name": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10325445" ], "products": [ "species_10316956" ], "modifiers": [ [ "species_10323745", "catalyst" ] ], "additional_components": [ "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "ENSXETT00000037000" ] }, "reaction_10325450": { "compartment": "compartment_984", "id": "reaction_10325450", "reactome": "R-XTR-2022396", "name": "Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10325445" ], "products": [ "species_10325432" ], "modifiers": [ [ "species_10325436", "catalyst" ] ], "additional_components": [ "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "ENSXETG00000007771" ] }, "reaction_10337782": { "compartment": "compartment_984", "id": "reaction_10337782", "reactome": "R-XTR-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10331304", "catalyst" ] ], "additional_components": [ "A0A5G3JDL4", "ENSXETT00000103127" ] }, "reaction_10325793": { "compartment": "compartment_984", "id": "reaction_10325793", "reactome": "R-XTR-2028294", "name": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10325445" ], "products": [ "species_10325426" ], "modifiers": [ [ "species_10325790", "catalyst" ] ], "additional_components": [ "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "A0A6I8PU97", "ENSXETG00000033023" ] }, "reaction_10317212": { "compartment": "compartment_984", "id": "reaction_10317212", "reactome": "R-XTR-381412", "name": "IGFBP2 binds IGF forming IGF:IGFBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317204", "species_10317208" ], "products": [ "species_10317210" ], "modifiers": [], "additional_components": [ "ENSXETT00000094605", "ENSXETT00000006287", "F7CZB7", "ENSXETT00000006287", "A4IIA2", "ENSXETT00000094605" ] }, "reaction_10317228": { "compartment": "compartment_984", "id": "reaction_10317228", "reactome": "R-XTR-381545", "name": "Formation of the IGF:IGFBP5:ALS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317216", "species_10317220", "species_10317208" ], "products": [ "species_10317222" ], "modifiers": [], "additional_components": [ "ENSXETG00000006623", "ENSXETT00000074759", "ENSXETT00000006287", "F7CZB7", "ENSXETT00000006287", "Q0IJ34", "ENSXETT00000074759", "A0A6I8PJ44", "ENSXETG00000006623" ] }, "reaction_10331191": { "compartment": "compartment_70101", "id": "reaction_10331191", "reactome": "R-XTR-5691512", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5691496", "species_29356" ], "products": [ "species_6785226", "species_5691517" ], "modifiers": [ [ "species_10331188", "catalyst" ] ], "additional_components": [ "species_5691517", "species_6785226", "ENSXETT00000050806" ] }, "reaction_10330583": { "compartment": "compartment_70101", "id": "reaction_10330583", "reactome": "R-XTR-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_5687529", "species_71285" ], "modifiers": [ [ "species_10330580", "catalyst" ] ], "additional_components": [ "ENSXETG00000017500" ] }, "reaction_10337612": { "compartment": "compartment_70101", "id": "reaction_10337612", "reactome": "R-XTR-9033232", "name": "PEX7 binds cargo proteins containing PTS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337604", "species_10337608" ], "products": [ "species_10337610" ], "modifiers": [], "additional_components": [ "ENSXETG00000027656", "ENSXETG00000008462", "A0A6I8R668", "ENSXETG00000008462", "A0A6I8SMH6", "ENSXETG00000027656" ] }, "reaction_10336877": { "compartment": "compartment_876", "id": "reaction_10336877", "reactome": "R-XTR-8951586", "name": "p-VAV family:PIP3 binds RAC1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325847", "species_10329285" ], "products": [ "species_10329291" ], "modifiers": [], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29420", "species_179838", "L7N3Q8", "ENSXETT00000043225", "species_179838", "L7N3Q8", "ENSXETT00000043225", "Q6GL60", "ENSXETT00000092508", "species_29420" ] }, "reaction_10329594": { "compartment": "compartment_876", "id": "reaction_10329594", "reactome": "R-XTR-5357445", "name": "PAK1-3 dimer disassociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329590" ], "products": [ "species_10329592" ], "modifiers": [], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "A0A6I8T271", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10329601": { "compartment": "compartment_876", "id": "reaction_10329601", "reactome": "R-XTR-5357472", "name": "PAK1-3 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10329592" ], "products": [ "species_29370", "species_10329598", "species_10329293" ], "modifiers": [ [ "species_10317378", "catalyst" ] ], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "A0A6I8T271", "ENSXETG00000011808", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10329603": { "compartment": "compartment_876", "id": "reaction_10329603", "reactome": "R-XTR-5357483", "name": "RAC1 binds PAK1-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317378", "species_10329293" ], "products": [ "species_10329590" ], "modifiers": [], "additional_components": [ "A0A6I8T271", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10329279": { "compartment": "compartment_70101", "id": "reaction_10329279", "reactome": "R-XTR-5218805", "name": "PKC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10329272" ], "products": [ "species_29370", "species_10329276" ], "modifiers": [ [ "species_10329272", "catalyst" ] ], "additional_components": [ "ENSXETG00000017294", "ENSXETG00000017294", "ENSXETG00000017294" ] }, "reaction_10329296": { "compartment": "compartment_876", "id": "reaction_10329296", "reactome": "R-XTR-5218850", "name": "VAV exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10329291" ], "products": [ "species_29420", "species_10329293" ], "modifiers": [ [ "species_10329291", "catalyst" ] ], "additional_components": [ "species_179838", "L7N3Q8", "ENSXETT00000043225", "Q6GL60", "ENSXETT00000092508", "species_29420", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "species_179838", "L7N3Q8", "ENSXETT00000043225", "Q6GL60", "ENSXETT00000092508", "species_29420" ] }, "reaction_10315879": { "compartment": "compartment_70101", "id": "reaction_10315879", "reactome": "R-XTR-202960", "name": "Caspase mediated cleavage of C-IAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315857" ], "products": [ "species_10315877", "species_10315867" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8QAZ5", "ENSXETG00000039278", "A0A6I8QAZ5", "ENSXETG00000039278", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8QAZ5", "ENSXETG00000039278", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10315839": { "compartment": "compartment_70101", "id": "reaction_10315839", "reactome": "R-XTR-202917", "name": "Caspase-mediated cleavage of Desmoglein 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315833" ], "products": [ "species_10315835", "species_10315837" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000034243", "ENSXETG00000034243", "ENSXETG00000034243", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10316731": { "compartment": "compartment_876", "id": "reaction_10316731", "reactome": "R-XTR-351913", "name": "Caspase-mediated cleavage of TJP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316727" ], "products": [ "species_10316729" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000020296", "ENSXETG00000020296", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10315674": { "compartment": "compartment_70101", "id": "reaction_10315674", "reactome": "R-XTR-201631", "name": "Caspase-mediated cleavage of Desmoglein 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315668" ], "products": [ "species_10315670", "species_10315672" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000034243", "ENSXETG00000034243", "ENSXETG00000034243", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10316723": { "compartment": "compartment_876", "id": "reaction_10316723", "reactome": "R-XTR-351877", "name": "Caspase-mediated cleavage of Desmoglein 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316719" ], "products": [ "species_10316721" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000034243", "ENSXETG00000034243", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10334778": { "compartment": "compartment_70101", "id": "reaction_10334778", "reactome": "R-XTR-8848726", "name": "PTK6 phosphorylates BCAR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334769", "species_113592" ], "products": [ "species_10334775", "species_10334679", "species_29370" ], "modifiers": [ [ "species_10334769", "catalyst" ] ], "additional_components": [ "L7N3R0", "ENSXETT00000043234", "A0A6I8Q2T5", "ENSXETG00000031017", "ENSXETT00000043234", "ENSXETG00000031017", "L7N3R0", "ENSXETT00000043234", "A0A6I8Q2T5", "ENSXETG00000031017" ] }, "reaction_10334771": { "compartment": "compartment_70101", "id": "reaction_10334771", "reactome": "R-XTR-8848713", "name": "PTK6 binds BCAR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334679", "species_10334767" ], "products": [ "species_10334769" ], "modifiers": [], "additional_components": [ "ENSXETG00000031017", "ENSXETT00000043234", "L7N3R0", "ENSXETT00000043234", "A0A6I8Q2T5", "ENSXETG00000031017" ] }, "reaction_10334782": { "compartment": "compartment_70101", "id": "reaction_10334782", "reactome": "R-XTR-8848930", "name": "PTK6 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334679" ], "products": [ "species_10334780" ], "modifiers": [], "additional_components": [ "ENSXETG00000031017", "ENSXETG00000031017" ] }, "reaction_10334792": { "compartment": "compartment_7660", "id": "reaction_10334792", "reactome": "R-XTR-8849032", "name": "PTK6 phosphorylates KHDRBS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334786", "species_29358" ], "products": [ "species_113582", "species_10334789" ], "modifiers": [ [ "species_10334780", "catalyst" ] ], "additional_components": [ "ENSXETG00000004451", "ENSXETG00000004451", "ENSXETG00000031017" ] }, "reaction_10334682": { "compartment": "compartment_70101", "id": "reaction_10334682", "reactome": "R-XTR-8848005", "name": "ERBB2 promotes PTK6 autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334674", "species_113592" ], "products": [ "species_10334679", "species_29370", "species_10322318" ], "modifiers": [ [ "species_10334674", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "A0A6I8Q2T5", "ENSXETG00000031017", "ENSXETG00000031017", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "A0A6I8Q2T5", "ENSXETG00000031017" ] }, "reaction_10334676": { "compartment": "compartment_876", "id": "reaction_10334676", "reactome": "R-XTR-8847995", "name": "Activated ERBB2 binds PTK6 (BRK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334672", "species_10322318" ], "products": [ "species_10334674" ], "modifiers": [], "additional_components": [ "ENSXETG00000031017", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "A0A6I8Q2T5", "ENSXETG00000031017" ] }, "reaction_10334802": { "compartment": "compartment_70101", "id": "reaction_10334802", "reactome": "R-XTR-8849102", "name": "SRMS phosphorylates PTK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334679", "species_113592" ], "products": [ "species_29370", "species_10334795" ], "modifiers": [ [ "species_10334799", "catalyst" ] ], "additional_components": [ "ENSXETG00000031017", "ENSXETG00000031017", "ENSXETG00000034490" ] }, "reaction_10318268": { "compartment": "compartment_876", "id": "reaction_10318268", "reactome": "R-XTR-442317", "name": "ZIP6 and ZIP14 mediate zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10318265", "catalyst" ] ], "additional_components": [ "ENSXETG00000010532" ] }, "reaction_10318288": { "compartment": "compartment_876", "id": "reaction_10318288", "reactome": "R-XTR-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10318285", "catalyst" ] ], "additional_components": [ "ENSXETG00000035832" ] }, "reaction_10337769": { "compartment": "compartment_70101", "id": "reaction_10337769", "reactome": "R-XTR-9614423", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316178", "species_10312804" ], "products": [ "species_10337767" ], "modifiers": [], "additional_components": [ "ENSXETT00000101788", "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830", "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830", "Q66JJ0", "ENSXETT00000101788" ] }, "reaction_10337765": { "compartment": "compartment_7660", "id": "reaction_10337765", "reactome": "R-XTR-9614414", "name": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315552" ], "products": [ "species_10316178" ], "modifiers": [], "additional_components": [ "ENSXETT00000101788", "ENSXETT00000101788" ] }, "reaction_10337071": { "compartment": "compartment_7660", "id": "reaction_10337071", "reactome": "R-XTR-8985343", "name": "RUNX2 binds SOX9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337067", "species_10335995" ], "products": [ "species_10337069" ], "modifiers": [], "additional_components": [ "ENSXETT00000087663", "ENSXETG00000001397", "Q6F2E7", "ENSXETT00000087663", "A0A6I8PZM7", "ENSXETG00000001397" ] }, "reaction_10336222": { "compartment": "compartment_7660", "id": "reaction_10336222", "reactome": "R-XTR-8938356", "name": "RMB14 binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336218", "species_10335995" ], "products": [ "species_10336220" ], "modifiers": [], "additional_components": [ "ENSXETG00000026650", "ENSXETG00000001397", "A0A6I8PZM7", "ENSXETG00000001397", "A0A6I8PSM7", "ENSXETG00000026650" ] }, "reaction_10336001": { "compartment": "compartment_7660", "id": "reaction_10336001", "reactome": "R-XTR-8877902", "name": "Activated AR binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335995", "species_10329949" ], "products": [ "species_10335999" ], "modifiers": [], "additional_components": [ "ENSXETG00000001397", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PZM7", "ENSXETG00000001397" ] }, "reaction_10317275": { "compartment": "compartment_7660", "id": "reaction_10317275", "reactome": "R-XTR-382096", "name": "Formation of NR-NCOR Corepressor Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317154", "species_10317271" ], "products": [ "species_10317273" ], "modifiers": [], "additional_components": [ "A4IIG7", "ENSXETT00000011580", "A0A6I8S377", "ENSXETT00000011580", "A0A6I8QVA7", "ENSXETG00000005219", "A0A6I8RH34", "ENSXETG00000031759", "F7EHW3", "ENSXETT00000025024", "F6SI83", "ENSXETT00000040897", "F6V3Y1", "ENSXETT00000012055", "A0A6I8S149", "ENSXETG00000040373", "F7C0K4", "ENSXETT00000050646", "A0A6I8QBV8", "ENSXETG00000021123", "Q28CK1", "ENSXETG00000023840", "A0A6I8QMK1", "ENSXETG00000007693", "F6WU58", "ENSXETT00000039111", "F7ETJ5", "ENSXETT00000028937", "F7BMW5", "ENSXETT00000027035", "Q66JK1", "ENSXETT00000090817", "A0A6I8RK73", "ENSXETG00000005089", "ENSXETG00000006720", "Q4KKX4", "ENSXETG00000006720", "A4IIG7", "ENSXETT00000011580", "A0A6I8S377", "ENSXETT00000011580", "A0A6I8QVA7", "ENSXETG00000005219", "A0A6I8RH34", "ENSXETG00000031759", "F7EHW3", "ENSXETT00000025024", "F6SI83", "ENSXETT00000040897", "F6V3Y1", "ENSXETT00000012055", "A0A6I8S149", "ENSXETG00000040373", "F7C0K4", "ENSXETT00000050646", "A0A6I8QBV8", "ENSXETG00000021123", "Q28CK1", "ENSXETG00000023840", "A0A6I8QMK1", "ENSXETG00000007693", "F6WU58", "ENSXETT00000039111", "F7ETJ5", "ENSXETT00000028937", "F7BMW5", "ENSXETT00000027035", "Q66JK1", "ENSXETT00000090817", "A0A6I8RK73", "ENSXETG00000005089" ] }, "reaction_10335895": { "compartment": "compartment_7660", "id": "reaction_10335895", "reactome": "R-XTR-8871260", "name": "YAP1 binds TEAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325861", "species_10325849" ], "products": [ "species_10335893" ], "modifiers": [], "additional_components": [ "ENSXETG00000036112", "ENSXETG00000032689", "A0A6I8SYU4", "ENSXETG00000032689", "A0A6I8SG09", "ENSXETG00000036112" ] }, "reaction_10325859": { "compartment": "compartment_7660", "id": "reaction_10325859", "reactome": "R-XTR-2032775", "name": "YAP1 binds TEAD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325849", "species_10325855" ], "products": [ "species_10325857" ], "modifiers": [], "additional_components": [ "ENSXETG00000032689", "ENSXETG00000036112", "A0A6I8SG09", "ENSXETG00000036112", "A0A6I8SYU4", "ENSXETG00000032689" ] }, "reaction_10326415": { "compartment": "compartment_70101", "id": "reaction_10326415", "reactome": "R-XTR-2187395", "name": "Dephosphorylated SMAD2/3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326413" ], "products": [ "species_10323441" ], "modifiers": [], "additional_components": [ "ENSXETT00000061335", "ENSXETT00000061335" ] }, "reaction_10337276": { "compartment": "compartment_876", "id": "reaction_10337276", "reactome": "R-XTR-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10325847" ], "products": [ "species_29420", "species_10312717" ], "modifiers": [ [ "species_10337273", "catalyst" ] ], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29420", "Q6GL60", "ENSXETT00000092508", "species_29438", "B1H2U7", "ENSXETT00000094272", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10337311": { "compartment": "compartment_876", "id": "reaction_10337311", "reactome": "R-XTR-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10312717" ], "products": [ "species_29372", "species_10325847" ], "modifiers": [ [ "species_10337308", "catalyst" ] ], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "Q6GL60", "ENSXETT00000092508", "species_29420", "Q08CX6", "ENSXETT00000056057", "A0A6I8SWA3", "ENSXETG00000032660", "A0A6I8SAF2", "ENSXETG00000004047", "F6UHQ8", "ENSXETT00000010378", "A0A6I8QAR5", "ENSXETG00000003287" ] }, "reaction_10337349": { "compartment": "compartment_876", "id": "reaction_10337349", "reactome": "R-XTR-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337345", "species_10325847" ], "products": [ "species_10337347" ], "modifiers": [], "additional_components": [ "ENSXETT00000020510", "Q6GL60", "ENSXETT00000092508", "species_29420", "F7D6Y2", "ENSXETT00000020510", "species_29420", "Q6GL60", "ENSXETT00000092508" ] }, "reaction_10338163": { "compartment": "compartment_876", "id": "reaction_10338163", "reactome": "R-XTR-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312717" ], "products": [ "species_10330027" ], "modifiers": [], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "Q6GL60", "ENSXETT00000092508", "species_29438" ] }, "reaction_10330269": { "compartment": "compartment_7660", "id": "reaction_10330269", "reactome": "R-XTR-5655193", "name": "KIAA0101 double monoubiquitination", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327687", "species_10330261" ], "products": [ "species_10330267" ], "modifiers": [], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "ENSXETT00000057278", "Q6AZL2", "ENSXETT00000057278", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858" ] }, "reaction_10312503": { "compartment": "compartment_7660", "id": "reaction_10312503", "reactome": "R-XTR-110322", "name": "Formation of Pol zeta complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312499", "species_10312495" ], "products": [ "species_10312501" ], "modifiers": [], "additional_components": [ "ENSXETT00000102467", "ENSXETG00000027754", "A0A6I8PTL2", "ENSXETG00000027754", "Q28H85", "ENSXETT00000102467" ] }, "reaction_10326699": { "compartment": "compartment_984", "id": "reaction_10326699", "reactome": "R-XTR-2395364", "name": "LTBP4 binds TGF-Beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326673", "species_10326683" ], "products": [ "species_10326697" ], "modifiers": [], "additional_components": [ "ENSXETG00000016967", "F6SX40", "ENSXETT00000046545", "F6SX40", "ENSXETT00000046545", "A0A6I8PY10", "ENSXETG00000016967" ] }, "reaction_10326695": { "compartment": "compartment_984", "id": "reaction_10326695", "reactome": "R-XTR-2395328", "name": "LTBP1, LTBP3 bind TGF-Beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326691", "species_10326685" ], "products": [ "species_10326693" ], "modifiers": [], "additional_components": [ "F6SX40", "ENSXETT00000046545", "A0A6I8RJM7", "ENSXETG00000019349", "A0A6I8S6N3", "ENSXETG00000008431", "A0A6I8RJM7", "ENSXETG00000019349", "A0A6I8S6N3", "ENSXETG00000008431", "F6SX40", "ENSXETT00000046545" ] }, "reaction_10327034": { "compartment": "compartment_876", "id": "reaction_10327034", "reactome": "R-XTR-2731078", "name": "Syndecans 2, (4) bind TGFB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313442", "species_10325703" ], "products": [ "species_10327032" ], "modifiers": [], "additional_components": [ "ENSXETT00000046545", "ENSXETG00000035467", "A0A6I8R5Q9", "ENSXETG00000035467", "F6SX40", "ENSXETT00000046545" ] }, "reaction_10326862": { "compartment": "compartment_984", "id": "reaction_10326862", "reactome": "R-XTR-2534248", "name": "DCN (decorin) degradation by MMP2, MMP3, MMP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326665" ], "products": [ "species_10326858", "species_10326860" ], "modifiers": [ [ "species_10323712", "catalyst" ] ], "additional_components": [ "ENSXETT00000063928", "ENSXETT00000063928", "ENSXETT00000063928", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801" ] }, "reaction_10323101": { "compartment": "compartment_984", "id": "reaction_10323101", "reactome": "R-XTR-1454757", "name": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323080" ], "products": [], "modifiers": [ [ "species_10323098", "catalyst" ] ], "additional_components": [ "Q6P4Z2", "ENSXETT00000043834", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8QL61", "ENSXETG00000022198", "A0A6I8RGF4", "ENSXETG00000002801", "F6ZRF9", "ENSXETT00000037915" ] }, "reaction_10323166": { "compartment": "compartment_984", "id": "reaction_10323166", "reactome": "R-XTR-1474197", "name": "Collagen type II degradation by MMP1,3,8,13,PRSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323151" ], "products": [ "species_10322559" ], "modifiers": [ [ "species_10323163", "catalyst" ] ], "additional_components": [ "Q6P4Z2", "ENSXETT00000043834", "Q6P4Z2", "ENSXETT00000043834", "A0A6I8QL61", "ENSXETG00000022198", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801" ] }, "reaction_10326201": { "compartment": "compartment_876", "id": "reaction_10326201", "reactome": "R-XTR-2167942", "name": "Collagen type XIII ectodomain shedding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326034" ], "products": [ "species_10326177", "species_10326175" ], "modifiers": [], "additional_components": [ "A0A6I8SFH9", "ENSXETG00000037705", "ENSXETG00000037705", "A0A6I8SFH9", "ENSXETG00000037705" ] }, "reaction_10326292": { "compartment": "compartment_984", "id": "reaction_10326292", "reactome": "R-XTR-2172433", "name": "Collagen type XIX degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326290" ], "products": [], "modifiers": [], "additional_components": [ "A0A6I8SFH9", "ENSXETG00000037705" ] }, "reaction_10323715": { "compartment": "compartment_984", "id": "reaction_10323715", "reactome": "R-XTR-1564142", "name": "Collagen type IV degradation by MMP2,3,4,9,10,12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323710" ], "products": [ "species_10323078" ], "modifiers": [ [ "species_10323712", "catalyst" ] ], "additional_components": [ "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801" ] }, "reaction_10323113": { "compartment": "compartment_984", "id": "reaction_10323113", "reactome": "R-XTR-1454781", "name": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323109", "species_10312984" ], "products": [ "species_10323111" ], "modifiers": [], "additional_components": [ "A0A6I8QL61", "ENSXETG00000022198", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801", "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942", "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942", "A0A6I8QL61", "ENSXETG00000022198", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801" ] }, "reaction_10334763": { "compartment": "compartment_70101", "id": "reaction_10334763", "reactome": "R-XTR-8848658", "name": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848706" ], "products": [ "species_8848709" ], "modifiers": [ [ "species_10334760", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "F7CZN1", "ENSXETT00000006277", "species_74112", "A0A6I8QL03", "ENSXETG00000030338" ] }, "reaction_10323839": { "compartment": "compartment_984", "id": "reaction_10323839", "reactome": "R-XTR-1602488", "name": "Initial activation of proMMP13 by plasmin and trypsin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323832" ], "products": [ "species_10323834", "species_10323836" ], "modifiers": [ [ "species_10323161", "catalyst" ] ], "additional_components": [ "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148" ] }, "reaction_10323881": { "compartment": "compartment_984", "id": "reaction_10323881", "reactome": "R-XTR-1604752", "name": "Initial activation of proMMP13 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323832" ], "products": [ "species_10323855", "species_10323868" ], "modifiers": [ [ "species_10323878", "catalyst" ] ], "additional_components": [ "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801", "F6ZRF9", "ENSXETT00000037915", "A0A6I8QK05", "ENSXETG00000027581", "A0A6I8SNY4", "ENSXETG00000035558" ] }, "reaction_10323864": { "compartment": "compartment_984", "id": "reaction_10323864", "reactome": "R-XTR-1604732", "name": "Autocatalytic activation of proMMP13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323853" ], "products": [ "species_10323857", "species_10323092" ], "modifiers": [ [ "species_10323853", "catalyst" ] ], "additional_components": [ "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801" ] }, "reaction_10323851": { "compartment": "compartment_984", "id": "reaction_10323851", "reactome": "R-XTR-1604731", "name": "Autocatalytic activation of MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323764" ], "products": [ "species_10323848", "species_10323096" ], "modifiers": [ [ "species_10323764", "catalyst" ] ], "additional_components": [ "ENSXETT00000037915", "ENSXETT00000037915", "ENSXETT00000037915", "ENSXETT00000037915" ] }, "reaction_10323781": { "compartment": "compartment_984", "id": "reaction_10323781", "reactome": "R-XTR-1592371", "name": "Initial activation of proMMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323762" ], "products": [ "species_10323766", "species_10323764" ], "modifiers": [ [ "species_10323778", "catalyst" ] ], "additional_components": [ "ENSXETT00000037915", "ENSXETT00000037915", "ENSXETT00000037915", "A0A6I8S6I3", "ENSXETG00000005867", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "A0A5G3K998", "ENSXETT00000090622" ] }, "reaction_10323735": { "compartment": "compartment_984", "id": "reaction_10323735", "reactome": "R-XTR-1592297", "name": "Full activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323732" ], "products": [ "species_10323084" ], "modifiers": [ [ "species_10323712", "catalyst" ] ], "additional_components": [ "ENSXETG00000022198", "ENSXETG00000022198", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801" ] }, "reaction_10323830": { "compartment": "compartment_984", "id": "reaction_10323830", "reactome": "R-XTR-1602473", "name": "Autocatalytic activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323739" ], "products": [ "species_10323827", "species_10323732" ], "modifiers": [ [ "species_10323739", "catalyst" ] ], "additional_components": [ "ENSXETG00000022198", "ENSXETG00000022198", "ENSXETG00000022198", "ENSXETG00000022198" ] }, "reaction_10323846": { "compartment": "compartment_984", "id": "reaction_10323846", "reactome": "R-XTR-1604359", "name": "Initial activation of proMMP2 by MMP1, 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323841" ], "products": [ "species_10323843", "species_10323725" ], "modifiers": [ [ "species_10323084", "catalyst" ] ], "additional_components": [ "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000022198" ] }, "reaction_10323825": { "compartment": "compartment_984", "id": "reaction_10323825", "reactome": "R-XTR-1602458", "name": "Activation of proMMP10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323820" ], "products": [ "species_10323103" ], "modifiers": [ [ "species_10323822", "catalyst" ] ], "additional_components": [ "ENSXETT00000037915", "ENSXETT00000037915", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "A0A5G3K998", "ENSXETT00000090622" ] }, "reaction_10323760": { "compartment": "compartment_984", "id": "reaction_10323760", "reactome": "R-XTR-1592316", "name": "Initial activation of proMMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323737" ], "products": [ "species_10323739", "species_10323741" ], "modifiers": [ [ "species_10323757", "catalyst" ] ], "additional_components": [ "ENSXETG00000022198", "ENSXETG00000022198", "ENSXETG00000022198", "A0A6I8S6I3", "ENSXETG00000005867", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "A0A6I8RBC3", "ENSXETG00000037351", "Q5HZU5", "ENSXETT00000093455", "A0A6I8QPJ5", "ENSXETG00000039590", "F7EHU5", "ENSXETT00000037000" ] }, "reaction_10323730": { "compartment": "compartment_984", "id": "reaction_10323730", "reactome": "R-XTR-1592278", "name": "Autocatalytic activation of proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323725" ], "products": [ "species_10323094", "species_10323727" ], "modifiers": [ [ "species_10323725", "catalyst" ] ], "additional_components": [ "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801" ] }, "reaction_10324621": { "compartment": "compartment_12045", "id": "reaction_10324621", "reactome": "R-XTR-1981104", "name": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10324614", "species_1650779" ], "products": [ "species_1650769", "species_10324618", "species_159751" ], "modifiers": [ [ "species_10324612", "catalyst" ] ], "additional_components": [ "species_435347", "F7D3M1", "ENSXETT00000023809", "species_435347", "F7D3M1", "ENSXETT00000023809", "species_435347", "F7D3M1", "ENSXETT00000023809" ] }, "reaction_10336797": { "compartment": "compartment_17957", "id": "reaction_10336797", "reactome": "R-XTR-8944250", "name": "Association of procollagen type XXV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325361" ], "products": [ "species_10325363" ], "modifiers": [], "additional_components": [ "ENSXETG00000035357", "A0A6I8STN5", "ENSXETG00000035357" ] }, "reaction_10336799": { "compartment": "compartment_17957", "id": "reaction_10336799", "reactome": "R-XTR-8944254", "name": "Association of procollagen type XXVI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325368" ], "products": [ "species_10325392" ], "modifiers": [], "additional_components": [ "ENSXETG00000035357", "A0A6I8STN5", "ENSXETG00000035357" ] }, "reaction_10336793": { "compartment": "compartment_17957", "id": "reaction_10336793", "reactome": "R-XTR-8944242", "name": "Association of procollagen type XXVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325394" ], "products": [ "species_10325418" ], "modifiers": [], "additional_components": [ "ENSXETT00000032928", "A0JP88", "ENSXETT00000032928" ] }, "reaction_10336795": { "compartment": "compartment_17957", "id": "reaction_10336795", "reactome": "R-XTR-8944246", "name": "Association of procollagen type XXI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325329" ], "products": [ "species_10325331" ], "modifiers": [], "additional_components": [ "ENSXETG00000034204", "A0A6I8RDS2", "ENSXETG00000034204" ] }, "reaction_10336805": { "compartment": "compartment_17957", "id": "reaction_10336805", "reactome": "R-XTR-8944265", "name": "Association of procollagen type IV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325154", "species_10325056", "species_10325206", "species_10325156", "species_10325182", "species_10325054" ], "products": [ "species_10325232" ], "modifiers": [], "additional_components": [ "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "ENSXETG00000001547", "ENSXETG00000001547", "ENSXETG00000001547", "ENSXETG00000001565", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565" ] }, "reaction_10336791": { "compartment": "compartment_17957", "id": "reaction_10336791", "reactome": "R-XTR-8944236", "name": "Association of procollagen type XIV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325272" ], "products": [ "species_10325298" ], "modifiers": [], "additional_components": [ "ENSXETG00000005761", "A0A6I8RGK2", "ENSXETG00000005761" ] }, "reaction_10336801": { "compartment": "compartment_17957", "id": "reaction_10336801", "reactome": "R-XTR-8944261", "name": "Association of procollagen type XIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325239" ], "products": [ "species_10325265" ], "modifiers": [], "additional_components": [ "ENSXETG00000037705", "A0A6I8SFH9", "ENSXETG00000037705" ] }, "reaction_10324656": { "compartment": "compartment_17957", "id": "reaction_10324656", "reactome": "R-XTR-2002401", "name": "Association of procollagen type XVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324628" ], "products": [ "species_10324654" ], "modifiers": [], "additional_components": [ "ENSXETT00000012721", "F6VQW0", "ENSXETT00000012721" ] }, "reaction_10336803": { "compartment": "compartment_17957", "id": "reaction_10336803", "reactome": "R-XTR-8944263", "name": "Association of procollagen type II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324956" ], "products": [ "species_10324980" ], "modifiers": [], "additional_components": [ "ENSXETT00000043834", "Q6P4Z2", "ENSXETT00000043834" ] }, "reaction_10336787": { "compartment": "compartment_17957", "id": "reaction_10336787", "reactome": "R-XTR-8944227", "name": "Association of procollagen type XXII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325336" ], "products": [ "species_10325357" ], "modifiers": [], "additional_components": [ "ENSXETG00000034204", "A0A6I8RDS2", "ENSXETG00000034204" ] }, "reaction_10326042": { "compartment": "compartment_17957", "id": "reaction_10326042", "reactome": "R-XTR-2152276", "name": "Secretion of transmembrane collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326008" ], "products": [ "species_10326040" ], "modifiers": [], "additional_components": [ "A0A6I8SFH9", "ENSXETG00000037705", "A0A6I8STN5", "ENSXETG00000035357", "A0A6I8STN5", "ENSXETG00000035357", "A0A6I8SFH9", "ENSXETG00000037705" ] }, "reaction_10326479": { "compartment": "compartment_984", "id": "reaction_10326479", "reactome": "R-XTR-2213207", "name": "Formation of collagen networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326477" ], "products": [ "species_10323710" ], "modifiers": [], "additional_components": [ "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547" ] }, "reaction_10326447": { "compartment": "compartment_984", "id": "reaction_10326447", "reactome": "R-XTR-2213201", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323205" ], "products": [ "species_10326445" ], "modifiers": [], "additional_components": [ "Q6P4Z2", "ENSXETT00000043834", "A0JP88", "ENSXETT00000032928", "Q6P4Z2", "ENSXETT00000043834", "A0JP88", "ENSXETT00000032928" ] }, "reaction_10326993": { "compartment": "compartment_984", "id": "reaction_10326993", "reactome": "R-XTR-2559639", "name": "Collagen type IV sulfilimine cross-linking by peroxidasin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_10323710" ], "products": [ "species_10326984" ], "modifiers": [ [ "species_10326990", "catalyst" ] ], "additional_components": [ "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8R6H3", "ENSXETG00000002635", "A4IGL7", "ENSXETG00000006965", "CHEBI:15858" ] }, "reaction_10323207": { "compartment": "compartment_984", "id": "reaction_10323207", "reactome": "R-XTR-1474266", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323201" ], "products": [ "species_10323205" ], "modifiers": [], "additional_components": [ "Q6P4Z2", "ENSXETT00000043834", "A0JP88", "ENSXETT00000032928", "Q6P4Z2", "ENSXETT00000043834", "A0JP88", "ENSXETT00000032928" ] }, "reaction_10326814": { "compartment": "compartment_984", "id": "reaction_10326814", "reactome": "R-XTR-2426450", "name": "Laminins:Nidogens binds collagen type IV networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326810", "species_10323710" ], "products": [ "species_10326812" ], "modifiers": [], "additional_components": [ "A0A6I8QYL3", "ENSXETG00000012279", "A0A6I8SMI4", "ENSXETG00000007336", "A0JP86", "ENSXETG00000012525", "A0A6I8RIS5", "ENSXETG00000012198", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8QYL3", "ENSXETG00000012279", "A0A6I8SMI4", "ENSXETG00000007336", "A0JP86", "ENSXETG00000012525", "A0A6I8RIS5", "ENSXETG00000012198" ] }, "reaction_10336708": { "compartment": "compartment_876", "id": "reaction_10336708", "reactome": "R-XTR-8941234", "name": "SH3PXD2A binds ADAM12,ADAM15,ADAM19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336704", "species_10336700" ], "products": [ "species_10336706" ], "modifiers": [], "additional_components": [ "ENSXETG00000034170", "species_1806238", "A0A6I8RHF6", "ENSXETG00000011399", "species_1806238", "A0A6I8RHF6", "ENSXETG00000011399", "A0A6I8PWV8", "ENSXETG00000034170" ] }, "reaction_10323437": { "compartment": "compartment_70101", "id": "reaction_10323437", "reactome": "R-XTR-1504213", "name": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323415", "species_10323417" ], "products": [ "species_10323419" ], "modifiers": [], "additional_components": [ "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8SYH3", "ENSXETG00000025907", "A4IHP4", "ENSXETT00000017945", "B1WAP7", "ENSXETT00000037606", "Q05AS8", "ENSXETG00000017212", "B1WAP7", "ENSXETT00000037606", "Q05AS8", "ENSXETG00000017212", "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8SYH3", "ENSXETG00000025907", "A4IHP4", "ENSXETT00000017945" ] }, "reaction_10323435": { "compartment": "compartment_70101", "id": "reaction_10323435", "reactome": "R-XTR-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312116", "species_10323419" ], "products": [ "species_10323432" ], "modifiers": [ [ "species_10323419", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "B1WAP7", "ENSXETT00000037606", "Q05AS8", "ENSXETG00000017212", "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8SYH3", "ENSXETG00000025907", "A4IHP4", "ENSXETT00000017945", "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8SYH3", "ENSXETG00000025907", "A4IHP4", "ENSXETT00000017945", "Q05AS8", "ENSXETG00000017212", "B1WAP7", "ENSXETT00000037606", "B1WAP7", "ENSXETT00000037606", "Q05AS8", "ENSXETG00000017212", "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8SYH3", "ENSXETG00000025907", "A4IHP4", "ENSXETT00000017945" ] }, "reaction_10328747": { "compartment": "compartment_70101", "id": "reaction_10328747", "reactome": "R-XTR-4641147", "name": "DACT1 binds DVL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328743", "species_10315690" ], "products": [ "species_10328745" ], "modifiers": [], "additional_components": [ "ENSXETG00000011962", "ENSXETG00000017212", "Q05AS8", "ENSXETG00000017212", "Q66KC9", "ENSXETG00000011962" ] }, "reaction_10328777": { "compartment": "compartment_876", "id": "reaction_10328777", "reactome": "R-XTR-4641246", "name": "ZNRF3 autoubiquitinates to promote its internalization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312116", "species_10328767" ], "products": [ "species_10328774" ], "modifiers": [ [ "species_10328767", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q08D68", "ENSXETT00000070371", "Q5M7L6", "ENSXETT00000065307", "A0A6I8PSP2", "ENSXETG00000030823", "Q08D68", "ENSXETT00000070371", "Q5M7L6", "ENSXETT00000065307", "A0A6I8PSP2", "ENSXETG00000030823", "Q08D68", "ENSXETT00000070371", "Q5M7L6", "ENSXETT00000065307", "A0A6I8PSP2", "ENSXETG00000030823" ] }, "reaction_10328795": { "compartment": "compartment_876", "id": "reaction_10328795", "reactome": "R-XTR-4641253", "name": "ZNRF3 ubiquitinates FZD to promote its downregulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328787", "species_10312116" ], "products": [ "species_10328792" ], "modifiers": [ [ "species_10328787", "catalyst" ] ], "additional_components": [ "Q08D68", "ENSXETT00000070371", "A0A6I8QRN7", "ENSXETG00000034910", "A0A6I8S584", "ENSXETG00000008917", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q08D68", "ENSXETT00000070371", "A0A6I8QRN7", "ENSXETG00000034910", "A0A6I8S584", "ENSXETG00000008917", "Q08D68", "ENSXETT00000070371", "A0A6I8QRN7", "ENSXETG00000034910", "A0A6I8S584", "ENSXETG00000008917" ] }, "reaction_10328769": { "compartment": "compartment_876", "id": "reaction_10328769", "reactome": "R-XTR-4641205", "name": "RSPO:LGR binds ZNRF3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328761", "species_10328765" ], "products": [ "species_10328767" ], "modifiers": [], "additional_components": [ "Q5M7L6", "ENSXETT00000065307", "A0A6I8PSP2", "ENSXETG00000030823", "ENSXETT00000070371", "Q08D68", "ENSXETT00000070371", "Q5M7L6", "ENSXETT00000065307", "A0A6I8PSP2", "ENSXETG00000030823" ] }, "reaction_10335855": { "compartment": "compartment_12045", "id": "reaction_10335855", "reactome": "R-XTR-8869206", "name": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8869214" ], "products": [ "species_29416", "species_8869207" ], "modifiers": [ [ "species_10335852", "catalyst" ] ], "additional_components": [ "ENSXETG00000040379" ] }, "reaction_10317819": { "compartment": "compartment_984", "id": "reaction_10317819", "reactome": "R-XTR-419490", "name": "Binding of ATP to P2X receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114570", "species_10312780" ], "products": [ "species_10312782" ], "modifiers": [], "additional_components": [ "ENSXETG00000041261", "A0A6I8S619", "ENSXETG00000041261", "species_113593" ] }, "reaction_10312785": { "compartment": "compartment_876", "id": "reaction_10312785", "reactome": "R-XTR-139855", "name": "P2X1-mediated entry of Ca++ from plasma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10312782", "catalyst" ] ], "additional_components": [ "A0A6I8S619", "ENSXETG00000041261", "species_113593" ] }, "reaction_10317725": { "compartment": "compartment_114521", "id": "reaction_10317725", "reactome": "R-XTR-418365", "name": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427899", "species_74016" ], "products": [ "species_70106", "species_139827" ], "modifiers": [ [ "species_10317722", "catalyst" ] ], "additional_components": [ "A0A6I8Q1N1", "ENSXETG00000002512", "A0A6I8RIR9", "ENSXETG00000009695" ] }, "reaction_10317712": { "compartment": "compartment_876", "id": "reaction_10317712", "reactome": "R-XTR-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10317709", "catalyst" ] ], "additional_components": [ "ENSXETG00000000441" ] }, "reaction_10328380": { "compartment": "compartment_70101", "id": "reaction_10328380", "reactome": "R-XTR-3928578", "name": "EPH receptors autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10328363" ], "products": [ "species_29370", "species_10328377" ], "modifiers": [ [ "species_10328363", "catalyst" ] ], "additional_components": [ "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R4R5", "ENSXETG00000017584", "A0A6I8R3N5", "ENSXETG00000018746", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584" ] }, "reaction_10328388": { "compartment": "compartment_876", "id": "reaction_10328388", "reactome": "R-XTR-3928646", "name": "EPHAs bind EFNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328359", "species_10328349" ], "products": [ "species_10328361" ], "modifiers": [], "additional_components": [ "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584" ] }, "reaction_10328519": { "compartment": "compartment_876", "id": "reaction_10328519", "reactome": "R-XTR-4093342", "name": "SDC2 multimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328515" ], "products": [ "species_10328517" ], "modifiers": [], "additional_components": [ "ENSXETG00000035467", "A0A6I8R5Q9", "ENSXETG00000035467" ] }, "reaction_10328384": { "compartment": "compartment_876", "id": "reaction_10328384", "reactome": "R-XTR-3928591", "name": "EPH:EFN tetramers oligomerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328361", "species_10328382" ], "products": [ "species_10328363" ], "modifiers": [], "additional_components": [ "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584" ] }, "reaction_10328386": { "compartment": "compartment_876", "id": "reaction_10328386", "reactome": "R-XTR-3928597", "name": "EPH:EFN dimers tetramerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328361" ], "products": [ "species_10328382" ], "modifiers": [], "additional_components": [ "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584" ] }, "reaction_10313950": { "compartment": "compartment_70101", "id": "reaction_10313950", "reactome": "R-XTR-183036", "name": "Ubiquitination of stimulated EGFR (CBL:GRB2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312116", "species_10313941" ], "products": [ "species_10313947" ], "modifiers": [ [ "species_10313941", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "Q66II3", "ENSXETT00000027387", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "Q66II3", "ENSXETT00000027387", "F7C8B9", "ENSXETT00000006761", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "Q66II3", "ENSXETT00000027387", "F7C8B9", "ENSXETT00000006761" ] }, "reaction_10313975": { "compartment": "compartment_70101", "id": "reaction_10313975", "reactome": "R-XTR-183058", "name": "Phosphorylation of CBL (EGFR:GRB2:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10313972" ], "products": [ "species_29370", "species_10313941" ], "modifiers": [ [ "species_10313972", "catalyst" ] ], "additional_components": [ "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "Q66II3", "ENSXETT00000027387", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10313968": { "compartment": "compartment_70101", "id": "reaction_10313968", "reactome": "R-XTR-183051", "name": "CBL ubiquitinates Sprouty", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312116", "species_10313961" ], "products": [ "species_10313965" ], "modifiers": [ [ "species_10313961", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8SCT0", "ENSXETG00000041240", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8SCT0", "ENSXETG00000041240", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8SCT0", "ENSXETG00000041240" ] }, "reaction_10313903": { "compartment": "compartment_70101", "id": "reaction_10313903", "reactome": "R-XTR-177934", "name": "EGFR autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313842", "species_113592" ], "products": [ "species_29370", "species_10313869" ], "modifiers": [ [ "species_10313842", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877" ] }, "reaction_10313900": { "compartment": "compartment_70101", "id": "reaction_10313900", "reactome": "R-XTR-177930", "name": "GAB1 phosphorylation by EGFR kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10313892" ], "products": [ "species_29370", "species_10313871" ], "modifiers": [ [ "species_10313892", "catalyst" ] ], "additional_components": [ "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838" ] }, "reaction_10313886": { "compartment": "compartment_70101", "id": "reaction_10313886", "reactome": "R-XTR-177924", "name": "Dephosphorylation of Gab1 by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10313873" ], "products": [ "species_29372", "species_10313883" ], "modifiers": [ [ "species_10313873", "catalyst" ] ], "additional_components": [ "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838" ] }, "reaction_10313913": { "compartment": "compartment_70101", "id": "reaction_10313913", "reactome": "R-XTR-177935", "name": "SHP2 dephosphorylates Tyr 992 on EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10313873" ], "products": [ "species_29372", "species_10313911" ], "modifiers": [ [ "species_10313873", "catalyst" ] ], "additional_components": [ "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838" ] }, "reaction_10313816": { "compartment": "compartment_70101", "id": "reaction_10313816", "reactome": "R-XTR-177920", "name": "Binding of GRB2 to GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313812", "species_10312043" ], "products": [ "species_10313814" ], "modifiers": [], "additional_components": [ "ENSXETT00000038110", "ENSXETT00000027387", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110" ] }, "reaction_10313924": { "compartment": "compartment_70101", "id": "reaction_10313924", "reactome": "R-XTR-177941", "name": "GRB2:GAB1 binds to phosphorylated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313890", "species_10313869" ], "products": [ "species_10313892" ], "modifiers": [], "additional_components": [ "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838" ] }, "reaction_10313937": { "compartment": "compartment_70101", "id": "reaction_10313937", "reactome": "R-XTR-179467", "name": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10313814" ], "products": [ "species_10313888" ], "modifiers": [], "additional_components": [ "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838" ] }, "reaction_10313922": { "compartment": "compartment_70101", "id": "reaction_10313922", "reactome": "R-XTR-177939", "name": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10313919", "catalyst" ] ], "additional_components": [ "A0A6I8RUB1", "ENSXETG00000007252", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838" ] }, "reaction_10313930": { "compartment": "compartment_984", "id": "reaction_10313930", "reactome": "R-XTR-177942", "name": "EGFR binds EGF ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313838", "species_10313820" ], "products": [ "species_10313840" ], "modifiers": [ [ "species_10313928", "inhibitor" ] ], "additional_components": [ "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "ENSXETT00000006761", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "ENSXETT00000017426" ] }, "reaction_10313844": { "compartment": "compartment_876", "id": "reaction_10313844", "reactome": "R-XTR-177922", "name": "EGFR dimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313840" ], "products": [ "species_10313842" ], "modifiers": [], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877" ] }, "reaction_10313935": { "compartment": "compartment_70101", "id": "reaction_10313935", "reactome": "R-XTR-177943", "name": "GRB2:SOS1 complex binds to EGF:EGFR complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312049", "species_10313869" ], "products": [ "species_10313933" ], "modifiers": [], "additional_components": [ "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10312326": { "compartment": "compartment_70101", "id": "reaction_10312326", "reactome": "R-XTR-109813", "name": "GRB2-1 binds SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312043", "species_10312047" ], "products": [ "species_10312049" ], "modifiers": [], "additional_components": [ "ENSXETT00000027387", "ENSXETT00000044021", "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10314255": { "compartment": "compartment_984", "id": "reaction_10314255", "reactome": "R-XTR-192475", "name": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10314252", "catalyst" ] ], "additional_components": [ "F6ZWX1", "ENSXETT00000007508" ] }, "reaction_10337016": { "compartment": "compartment_984", "id": "reaction_10337016", "reactome": "R-XTR-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10337013", "catalyst" ] ], "additional_components": [] }, "reaction_10314244": { "compartment": "compartment_984", "id": "reaction_10314244", "reactome": "R-XTR-192434", "name": "Digestion of diacylglycerols by extracellular PTL:colipase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_174675" ], "products": [ "species_6814795", "species_174602" ], "modifiers": [ [ "species_10314239", "catalyst" ] ], "additional_components": [ "F6ZWX1", "ENSXETT00000007508" ] }, "reaction_10314242": { "compartment": "compartment_984", "id": "reaction_10314242", "reactome": "R-XTR-192422", "name": "Digestion of triacylglycerols by extracellular PTL:colipase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10314239", "catalyst" ] ], "additional_components": [ "F6ZWX1", "ENSXETT00000007508" ] }, "reaction_10329311": { "compartment": "compartment_7660", "id": "reaction_10329311", "reactome": "R-XTR-5218952", "name": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10327320" ], "products": [ "species_77502", "species_10329304" ], "modifiers": [ [ "species_10329308", "catalyst" ] ], "additional_components": [ "ENSXETG00000006676" ] }, "reaction_10329214": { "compartment": "compartment_7660", "id": "reaction_10329214", "reactome": "R-XTR-5205867", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10329171" ], "products": [ "species_77502", "species_10329211" ], "modifiers": [ [ "species_10327331", "catalyst" ] ], "additional_components": [ "ENSXETT00000094658" ] }, "reaction_10329098": { "compartment": "compartment_7660", "id": "reaction_10329098", "reactome": "R-XTR-5205820", "name": "PRMT6 methylates arginine-4 of histone H2A (H2AR3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10329055" ], "products": [ "species_77502", "species_10329095" ], "modifiers": [ [ "species_10329010", "catalyst" ] ], "additional_components": [ "ENSXETG00000009939" ] }, "reaction_10329429": { "compartment": "compartment_7660", "id": "reaction_10329429", "reactome": "R-XTR-5229203", "name": "PRMT6 methylates histone H2A arginine-30 (H2AR29)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10329387" ], "products": [ "species_77502", "species_10329427" ], "modifiers": [ [ "species_10329010", "catalyst" ] ], "additional_components": [ "ENSXETG00000009939" ] }, "reaction_10329124": { "compartment": "compartment_7660", "id": "reaction_10329124", "reactome": "R-XTR-5205824", "name": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10329112" ], "products": [ "species_77502", "species_10329122" ], "modifiers": [ [ "species_10329010", "catalyst" ] ], "additional_components": [ "ENSXETG00000009939" ] }, "reaction_10329015": { "compartment": "compartment_7660", "id": "reaction_10329015", "reactome": "R-XTR-5205798", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313794", "species_77087" ], "products": [ "species_77502", "species_10329006" ], "modifiers": [ [ "species_10329012", "catalyst" ] ], "additional_components": [ "ENSXETG00000035354", "ENSXETG00000035354", "Q28F07", "ENSXETT00000094658", "B0JYW5", "ENSXETG00000009939" ] }, "reaction_10330343": { "compartment": "compartment_7660", "id": "reaction_10330343", "reactome": "R-XTR-5661126", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10329006" ], "products": [ "species_77502", "species_10330341" ], "modifiers": [ [ "species_10329012", "catalyst" ] ], "additional_components": [ "ENSXETG00000035354", "ENSXETG00000035354", "Q28F07", "ENSXETT00000094658", "B0JYW5", "ENSXETG00000009939" ] }, "reaction_10329334": { "compartment": "compartment_7660", "id": "reaction_10329334", "reactome": "R-XTR-5225649", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316471", "species_10327320" ], "products": [ "species_10329332" ], "modifiers": [ [ "species_10329304", "inhibitor" ] ], "additional_components": [ "ENSXETT00000002157", "Q6P315", "ENSXETT00000002157" ] }, "reaction_10329330": { "compartment": "compartment_7660", "id": "reaction_10329330", "reactome": "R-XTR-5225602", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329304", "species_10329326" ], "products": [ "species_10329328" ], "modifiers": [], "additional_components": [ "ENSXETT00000102075", "Q5M786", "ENSXETT00000102075" ] }, "reaction_10326338": { "compartment": "compartment_70101", "id": "reaction_10326338", "reactome": "R-XTR-2176452", "name": "Degradation of ubiquitinated SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326336" ], "products": [], "modifiers": [], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q07G47", "ENSXETT00000061335" ] }, "reaction_10337420": { "compartment": "compartment_876", "id": "reaction_10337420", "reactome": "R-XTR-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337392", "species_10337416" ], "products": [ "species_10337418" ], "modifiers": [], "additional_components": [ "B1H300", "ENSXETT00000065865", "species_29438", "A0A6I8SQB3", "ENSXETG00000005314", "A0A6I8SBQ3", "ENSXETG00000021139", "A0A6I8T271", "ENSXETG00000011808", "A0A6I8SQB3", "ENSXETG00000005314", "A0A6I8SBQ3", "ENSXETG00000021139", "A0A6I8T271", "ENSXETG00000011808", "B1H300", "ENSXETT00000065865", "species_29438" ] }, "reaction_10337396": { "compartment": "compartment_876", "id": "reaction_10337396", "reactome": "R-XTR-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337392", "species_10337345" ], "products": [ "species_10337394" ], "modifiers": [], "additional_components": [ "B1H300", "ENSXETT00000065865", "species_29438", "ENSXETT00000020510", "F7D6Y2", "ENSXETT00000020510", "B1H300", "ENSXETT00000065865", "species_29438" ] }, "reaction_10337398": { "compartment": "compartment_876", "id": "reaction_10337398", "reactome": "R-XTR-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10337390" ], "products": [ "species_10337392" ], "modifiers": [], "additional_components": [ "ENSXETT00000065865", "B1H300", "ENSXETT00000065865", "species_29438" ] }, "reaction_10319096": { "compartment": "compartment_20699", "id": "reaction_10319096", "reactome": "R-XTR-744230", "name": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_744239" ], "products": [ "species_113578", "species_744233" ], "modifiers": [ [ "species_10319093", "catalyst" ] ], "additional_components": [ "ENSXETG00000041312" ] }, "reaction_10312321": { "compartment": "compartment_70101", "id": "reaction_10312321", "reactome": "R-XTR-109538", "name": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737", "species_74113" ], "products": [ "species_179743", "species_83910" ], "modifiers": [ [ "species_10312318", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_8857850", "CHEBI:17562", "species_8857850", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "ENSXETG00000011724" ] }, "reaction_10329473": { "compartment": "compartment_5460", "id": "reaction_10329473", "reactome": "R-XTR-5250210", "name": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329471" ], "products": [ "species_10329463" ], "modifiers": [], "additional_components": [ "Q5FW25", "ENSXETT00000039869", "F7BJL3", "ENSXETT00000003496", "species_29438", "Q5FW25", "ENSXETT00000039869", "F7BJL3", "ENSXETT00000003496", "species_29438" ] }, "reaction_10329475": { "compartment": "compartment_70101", "id": "reaction_10329475", "reactome": "R-XTR-5250217", "name": "ARL2:GTP binds ARL2BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329467", "species_10329469" ], "products": [ "species_10329471" ], "modifiers": [], "additional_components": [ "F7BJL3", "ENSXETT00000003496", "species_29438", "ENSXETT00000039869", "Q5FW25", "ENSXETT00000039869", "F7BJL3", "ENSXETT00000003496", "species_29438" ] }, "reaction_10316666": { "compartment": "compartment_984", "id": "reaction_10316666", "reactome": "R-XTR-349657", "name": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316664", "species_171095", "species_171142" ], "products": [ "species_10316576" ], "modifiers": [], "additional_components": [ "A0A6I8PU04", "ENSXETG00000033423", "species_163579", "species_171142", "species_216762", "A0A6I8PU04", "ENSXETG00000033423", "species_171142", "species_216762" ] }, "reaction_10316578": { "compartment": "compartment_984", "id": "reaction_10316578", "reactome": "R-XTR-216756", "name": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171095", "species_171142", "species_10313516" ], "products": [ "species_10316576" ], "modifiers": [], "additional_components": [ "ENSXETG00000033423", "A0A6I8PU04", "ENSXETG00000033423", "species_171142", "species_216762" ] }, "reaction_10312324": { "compartment": "compartment_70101", "id": "reaction_10312324", "reactome": "R-XTR-109699", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10312070", "catalyst" ] ], "additional_components": [ "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252", "A0A6I8RAF1", "ENSXETG00000039550" ] }, "reaction_10312072": { "compartment": "compartment_70101", "id": "reaction_10312072", "reactome": "R-XTR-74737", "name": "p-Y-IRS1,p-Y-IRS2 bind PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312054", "species_10312068" ], "products": [ "species_10312070" ], "modifiers": [], "additional_components": [ "ENSXETG00000039550", "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252", "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252", "A0A6I8RAF1", "ENSXETG00000039550" ] }, "reaction_10312058": { "compartment": "compartment_70101", "id": "reaction_10312058", "reactome": "R-XTR-74736", "name": "GRB2-1:SOS1 binds p-IRS1,p-IRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312049", "species_10312054" ], "products": [ "species_10312056" ], "modifiers": [], "additional_components": [ "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387", "ENSXETG00000039550", "A0A6I8RAF1", "ENSXETG00000039550", "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10316221": { "compartment": "compartment_7660", "id": "reaction_10316221", "reactome": "R-XTR-211207", "name": "Cleaved fragments of DFF45 dissociate from DFF40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316198" ], "products": [ "species_10316194", "species_10316196", "species_10316184", "species_10316188" ], "modifiers": [], "additional_components": [ "F6TTW7", "ENSXETT00000013820", "F7EHJ0", "ENSXETT00000013293", "ENSXETT00000013820", "ENSXETT00000013820", "ENSXETT00000013293", "ENSXETT00000013820" ] }, "reaction_10316223": { "compartment": "compartment_13231", "id": "reaction_10316223", "reactome": "R-XTR-211219", "name": "Translocation of caspase-3 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312650" ], "products": [ "species_10316206" ], "modifiers": [], "additional_components": [ "A0A6I8PZK4", "ENSXETG00000030678", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10316219": { "compartment": "compartment_7660", "id": "reaction_10316219", "reactome": "R-XTR-211193", "name": "Homodimerization of DFF40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316184" ], "products": [ "species_10316217" ], "modifiers": [], "additional_components": [ "ENSXETT00000013293", "F7EHJ0", "ENSXETT00000013293" ] }, "reaction_10316346": { "compartment": "compartment_7660", "id": "reaction_10316346", "reactome": "R-XTR-211247", "name": "Cleavage of DNA by DFF40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316339" ], "products": [ "species_10316337", "species_10316343" ], "modifiers": [ [ "species_10316339", "catalyst" ] ], "additional_components": [ "Q6NVM0", "ENSXETT00000101169", "F7EHJ0", "ENSXETT00000013293", "F7EHJ0", "ENSXETT00000013293", "Q6NVM0", "ENSXETT00000101169", "Q6NVM0", "ENSXETT00000101169", "F7EHJ0", "ENSXETT00000013293" ] }, "reaction_10316341": { "compartment": "compartment_7660", "id": "reaction_10316341", "reactome": "R-XTR-211239", "name": "Association of DFF40 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316337", "species_10316333" ], "products": [ "species_10316339" ], "modifiers": [], "additional_components": [ "F7EHJ0", "ENSXETT00000013293", "Q6NVM0", "ENSXETT00000101169", "Q6NVM0", "ENSXETT00000101169", "F7EHJ0", "ENSXETT00000013293" ] }, "reaction_10316231": { "compartment": "compartment_70101", "id": "reaction_10316231", "reactome": "R-XTR-211224", "name": "Association of DFF40 with DFF45", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316227", "species_10316225" ], "products": [ "species_10316229" ], "modifiers": [], "additional_components": [ "ENSXETT00000013293", "ENSXETT00000013820", "F6TTW7", "ENSXETT00000013820", "F7EHJ0", "ENSXETT00000013293" ] }, "reaction_10316215": { "compartment": "compartment_7660", "id": "reaction_10316215", "reactome": "R-XTR-211190", "name": "Caspase 3-mediated cleavage of DFF45 (117)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316213" ], "products": [ "species_10316192" ], "modifiers": [ [ "species_10316206", "catalyst" ] ], "additional_components": [ "F7EHJ0", "ENSXETT00000013293", "F6TTW7", "ENSXETT00000013820", "F6TTW7", "ENSXETT00000013820", "F7EHJ0", "ENSXETT00000013293", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10316209": { "compartment": "compartment_70101", "id": "reaction_10316209", "reactome": "R-XTR-211186", "name": "Cleavage of DFF45 (224) by caspase-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316192" ], "products": [ "species_10316198" ], "modifiers": [ [ "species_10316206", "catalyst" ] ], "additional_components": [ "F6TTW7", "ENSXETT00000013820", "F7EHJ0", "ENSXETT00000013293", "F6TTW7", "ENSXETT00000013820", "F7EHJ0", "ENSXETT00000013293", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10316073": { "compartment": "compartment_70101", "id": "reaction_10316073", "reactome": "R-XTR-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10316042" ], "products": [ "species_29420", "species_10316044" ], "modifiers": [ [ "species_10316070", "catalyst" ] ], "additional_components": [ "species_29420", "Q6GL60", "ENSXETT00000092508", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8QGS5", "ENSXETG00000038787", "F7DKF6", "ENSXETT00000044021", "A4II46", "ENSXETT00000074782", "A0A6I8Q734", "ENSXETG00000009131", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10316650": { "compartment": "compartment_984", "id": "reaction_10316650", "reactome": "R-XTR-265456", "name": "NPC1L1 inactivation by ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316646", "species_265479" ], "products": [ "species_10316648" ], "modifiers": [], "additional_components": [ "ENSXETG00000019001", "species_265479", "A0A6I8Q9Y0", "ENSXETG00000019001" ] }, "reaction_10330543": { "compartment": "compartment_70101", "id": "reaction_10330543", "reactome": "R-XTR-5675470", "name": "BIRC2/3 (cIAP1/2) is autoubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330519", "species_10329611" ], "products": [ "species_10330540" ], "modifiers": [ [ "species_10329611", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8QAZ5", "ENSXETG00000039278", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8QAZ5", "ENSXETG00000039278", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8QAZ5", "ENSXETG00000039278" ] }, "reaction_10338143": { "compartment": "compartment_70101", "id": "reaction_10338143", "reactome": "R-XTR-9688831", "name": "STUB1 ubiquitinates RIPK3 at K55, K363", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338134", "species_10312116" ], "products": [ "species_10338140" ], "modifiers": [ [ "species_10338134", "catalyst" ] ], "additional_components": [ "A0A6I8QJD3", "ENSXETG00000038971", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8QJD3", "ENSXETG00000038971", "A0A6I8QJD3", "ENSXETG00000038971" ] }, "reaction_10338120": { "compartment": "compartment_876", "id": "reaction_10338120", "reactome": "R-XTR-9686930", "name": "RIPK3 is cleaved by CASP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338114" ], "products": [ "species_10338118", "species_10338116" ], "modifiers": [ [ "species_10316682", "catalyst" ] ], "additional_components": [ "ENSXETG00000038971", "ENSXETG00000038971", "ENSXETG00000038971", "A0A6I8Q0P2", "ENSXETG00000032748" ] }, "reaction_10338145": { "compartment": "compartment_70101", "id": "reaction_10338145", "reactome": "R-XTR-9688838", "name": "RIPK3 binds STUB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338114", "species_10338132" ], "products": [ "species_10338134" ], "modifiers": [], "additional_components": [ "ENSXETG00000038971", "A0A6I8QJD3", "ENSXETG00000038971" ] }, "reaction_10338130": { "compartment": "compartment_70101", "id": "reaction_10338130", "reactome": "R-XTR-9687828", "name": "O-GlcNAcylation of RIPK3 (TLR4 signaling)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338114", "species_162756" ], "products": [ "species_10338123", "species_110096" ], "modifiers": [ [ "species_10338127", "catalyst" ] ], "additional_components": [ "ENSXETG00000038971", "ENSXETG00000038971", "ENSXETT00000034743" ] }, "reaction_10318991": { "compartment": "compartment_17906", "id": "reaction_10318991", "reactome": "R-XTR-508162", "name": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318987", "species_10312812" ], "products": [ "species_10318989" ], "modifiers": [], "additional_components": [ "ENSXETT00000050759", "ENSXETG00000031875", "A0A6I8PXS6", "ENSXETG00000031875", "F6XC18", "ENSXETT00000050759" ] }, "reaction_10312680": { "compartment": "compartment_17906", "id": "reaction_10312680", "reactome": "R-XTR-114263", "name": "Oligomerization of BAK at the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312676" ], "products": [ "species_10312678" ], "modifiers": [], "additional_components": [ "ENSXETG00000038338", "A0A6I8QFQ5", "ENSXETG00000038338" ] }, "reaction_10312692": { "compartment": "compartment_17906", "id": "reaction_10312692", "reactome": "R-XTR-114275", "name": "Oligomerization of BAX at the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312686" ], "products": [ "species_10312690" ], "modifiers": [], "additional_components": [ "ENSXETT00000031936", "F6TEC3", "ENSXETT00000031936" ] }, "reaction_10312688": { "compartment": "compartment_70101", "id": "reaction_10312688", "reactome": "R-XTR-114264", "name": "Translocation of activated BAX to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312684" ], "products": [ "species_10312686" ], "modifiers": [], "additional_components": [ "ENSXETT00000031936", "ENSXETT00000031936" ] }, "reaction_10312412": { "compartment": "compartment_7660", "id": "reaction_10312412", "reactome": "R-XTR-110218", "name": "Cleavage of uracil by TDG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312407" ], "products": [ "species_10312409", "species_29554" ], "modifiers": [ [ "species_10312407", "catalyst" ] ], "additional_components": [ "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927" ] }, "reaction_10312428": { "compartment": "compartment_7660", "id": "reaction_10312428", "reactome": "R-XTR-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312423" ], "products": [ "species_110223", "species_10312425" ], "modifiers": [ [ "species_10312423", "catalyst" ] ], "additional_components": [ "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540" ] }, "reaction_10312476": { "compartment": "compartment_7660", "id": "reaction_10312476", "reactome": "R-XTR-110234", "name": "Cleavage of ethenocytosine by TDG glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312473" ], "products": [ "species_110233", "species_10312409" ], "modifiers": [ [ "species_10312473", "catalyst" ] ], "additional_components": [ "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927" ] }, "reaction_10312398": { "compartment": "compartment_7660", "id": "reaction_10312398", "reactome": "R-XTR-110215", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312391" ], "products": [ "species_10312395", "species_29554" ], "modifiers": [ [ "species_10312391", "catalyst" ] ], "additional_components": [ "F6V364", "ENSXETT00000048248", "F6V364", "ENSXETT00000048248", "F6V364", "ENSXETT00000048248" ] }, "reaction_10312462": { "compartment": "compartment_7660", "id": "reaction_10312462", "reactome": "R-XTR-110231", "name": "Cleavage of uracil by MBD4 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312457" ], "products": [ "species_10312459", "species_29554" ], "modifiers": [ [ "species_10312457", "catalyst" ] ], "additional_components": [ "A0A6I8PM79", "ENSXETG00000026622", "A0A6I8PM79", "ENSXETG00000026622", "A0A6I8PM79", "ENSXETG00000026622" ] }, "reaction_10312442": { "compartment": "compartment_7660", "id": "reaction_10312442", "reactome": "R-XTR-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312439" ], "products": [ "species_30140", "species_10312425" ], "modifiers": [ [ "species_10312439", "catalyst" ] ], "additional_components": [ "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540" ] }, "reaction_10312405": { "compartment": "compartment_7660", "id": "reaction_10312405", "reactome": "R-XTR-110217", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312402" ], "products": [ "species_110216", "species_10312395" ], "modifiers": [ [ "species_10312402", "catalyst" ] ], "additional_components": [ "F6V364", "ENSXETT00000048248", "F6V364", "ENSXETT00000048248", "F6V364", "ENSXETT00000048248" ] }, "reaction_10312469": { "compartment": "compartment_7660", "id": "reaction_10312469", "reactome": "R-XTR-110232", "name": "Cleavage of thymine by MBD4 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312466" ], "products": [ "species_29692", "species_10312459" ], "modifiers": [ [ "species_10312466", "catalyst" ] ], "additional_components": [ "A0A6I8PM79", "ENSXETG00000026622", "A0A6I8PM79", "ENSXETG00000026622", "A0A6I8PM79", "ENSXETG00000026622" ] }, "reaction_10330164": { "compartment": "compartment_7660", "id": "reaction_10330164", "reactome": "R-XTR-5649681", "name": "NEIL2 cleaves 5-OHU from damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330159" ], "products": [ "species_10330161", "species_110216" ], "modifiers": [ [ "species_10330159", "catalyst" ] ], "additional_components": [ "F7D0D2", "ENSXETT00000051487", "F7D0D2", "ENSXETT00000051487", "F7D0D2", "ENSXETT00000051487" ] }, "reaction_10312449": { "compartment": "compartment_7660", "id": "reaction_10312449", "reactome": "R-XTR-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312446" ], "products": [ "species_5637659", "species_10312425" ], "modifiers": [ [ "species_10312446", "catalyst" ] ], "additional_components": [ "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540" ] }, "reaction_10312419": { "compartment": "compartment_7660", "id": "reaction_10312419", "reactome": "R-XTR-110219", "name": "Cleavage of thymine by TDG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312416" ], "products": [ "species_29692", "species_10312409" ], "modifiers": [ [ "species_10312416", "catalyst" ] ], "additional_components": [ "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927" ] }, "reaction_10312435": { "compartment": "compartment_7660", "id": "reaction_10312435", "reactome": "R-XTR-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312432" ], "products": [ "species_10312425", "species_110225" ], "modifiers": [ [ "species_10312432", "catalyst" ] ], "additional_components": [ "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540" ] }, "reaction_10316654": { "compartment": "compartment_984", "id": "reaction_10316654", "reactome": "R-XTR-266089", "name": "Discoidal HDL binds membrane-associated free cholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316576", "species_171095" ], "products": [ "species_10316652" ], "modifiers": [], "additional_components": [ "A0A6I8PU04", "ENSXETG00000033423", "species_171142", "species_216762", "A0A6I8PU04", "ENSXETG00000033423", "species_171142", "species_216762" ] }, "reaction_10316660": { "compartment": "compartment_984", "id": "reaction_10316660", "reactome": "R-XTR-266299", "name": "Spherical HDL binds membrane-associated free cholesterol and phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316656", "species_171095", "species_171142" ], "products": [ "species_10316658" ], "modifiers": [], "additional_components": [ "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "species_171142", "species_216762", "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "species_171142", "species_216762" ] }, "reaction_10331331": { "compartment": "compartment_984", "id": "reaction_10331331", "reactome": "R-XTR-5694109", "name": "LIPC dimer hydrolyses TAG to DAG and FA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_422024", "species_174675" ], "modifiers": [ [ "species_10331328", "catalyst" ] ], "additional_components": [ "species_1604784" ] }, "reaction_10332258": { "compartment": "compartment_984", "id": "reaction_10332258", "reactome": "R-XTR-6785213", "name": "LIPC dimer binds heparin", "reversible": "false", "notes": "", "reactants": [ "species_1604784", "species_10331326" ], "products": [ "species_10331328" ], "modifiers": [], "additional_components": [ "species_1604784" ] }, "reaction_10313538": { "compartment": "compartment_984", "id": "reaction_10313538", "reactome": "R-XTR-174739", "name": "chylomicron remnant + apoE => chylomicron remnant:apoE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313530", "species_10313532" ], "products": [ "species_10313534" ], "modifiers": [], "additional_components": [ "ENSXETT00000100802", "species_171126", "species_163579", "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "Q6P615", "ENSXETT00000100802", "species_216762", "species_171126", "species_163579", "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "Q6P615", "ENSXETT00000100802", "species_216762" ] }, "reaction_10317772": { "compartment": "compartment_204883", "id": "reaction_10317772", "reactome": "R-XTR-419001", "name": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140648", "species_10317768" ], "products": [ "species_10317770" ], "modifiers": [], "additional_components": [ "A0A6I8SWY9", "ENSXETG00000011269", "A0A6I8RR45", "ENSXETG00000020131", "F6XNI3", "ENSXETT00000034059", "A0A6I8SWY9", "ENSXETG00000011269", "A0A6I8RR45", "ENSXETG00000020131", "F6XNI3", "ENSXETT00000034059" ] }, "reaction_10318171": { "compartment": "compartment_876", "id": "reaction_10318171", "reactome": "R-XTR-433711", "name": "Cis-homodimerization of nectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317776" ], "products": [ "species_10317778" ], "modifiers": [], "additional_components": [ "ENSXETT00000020211", "F7E015", "ENSXETT00000020211" ] }, "reaction_10317893": { "compartment": "compartment_204883", "id": "reaction_10317893", "reactome": "R-XTR-420593", "name": "PVR:PVRL3 trans heterodimer interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317776", "species_10314618" ], "products": [ "species_10317891" ], "modifiers": [], "additional_components": [ "ENSXETT00000020211", "ENSXETG00000038811", "A0A6I8QUW8", "ENSXETG00000038811", "F7E015", "ENSXETT00000020211" ] }, "reaction_10317782": { "compartment": "compartment_204883", "id": "reaction_10317782", "reactome": "R-XTR-419011", "name": "Transhomodimerization of Nectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317778" ], "products": [ "species_10317780" ], "modifiers": [], "additional_components": [ "F7E015", "ENSXETT00000020211", "F7E015", "ENSXETT00000020211" ] }, "reaction_10331249": { "compartment": "compartment_984", "id": "reaction_10331249", "reactome": "R-XTR-5692437", "name": "ANG binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331241", "species_10331245" ], "products": [ "species_10331247" ], "modifiers": [], "additional_components": [ "ENSXETG00000038487", "A0A6I8R6T7", "ENSXETG00000038487" ] }, "reaction_10317889": { "compartment": "compartment_204883", "id": "reaction_10317889", "reactome": "R-XTR-420592", "name": "Transhomodimerization of Nectin-like (Necl) proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317885" ], "products": [ "species_10317887" ], "modifiers": [], "additional_components": [ "Q6DJ83", "ENSXETG00000026489", "Q6DJ83", "ENSXETG00000026489" ] }, "reaction_10337532": { "compartment": "compartment_70101", "id": "reaction_10337532", "reactome": "R-XTR-9023912", "name": "AGO2 cleaves passenger strand of duplex siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325973" ], "products": [ "species_10337529" ], "modifiers": [ [ "species_10325973", "catalyst" ] ], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "Q6DJB9", "ENSXETT00000051244", "Q6DJB9", "ENSXETT00000051244" ] }, "reaction_10317966": { "compartment": "compartment_70101", "id": "reaction_10317966", "reactome": "R-XTR-426464", "name": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426463", "species_10315976" ], "products": [ "species_10317963" ], "modifiers": [ [ "species_10315976", "catalyst" ] ], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175", "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175", "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175" ] }, "reaction_10325989": { "compartment": "compartment_70101", "id": "reaction_10325989", "reactome": "R-XTR-2106625", "name": "Duplex siRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317963" ], "products": [ "species_10325979" ], "modifiers": [], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175", "B3DLA6", "ENSXETT00000096069", "Q6DJB9", "ENSXETT00000051244", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175" ] }, "reaction_10325987": { "compartment": "compartment_70101", "id": "reaction_10325987", "reactome": "R-XTR-2106615", "name": "Removal of siRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325979" ], "products": [ "species_10325985" ], "modifiers": [], "additional_components": [ "B3DLA6", "ENSXETT00000096069", "Q6DJB9", "ENSXETT00000051244", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175", "B3DLA6", "ENSXETT00000096069", "A0A6I8S266", "ENSXETG00000036175", "Q6DJB9", "ENSXETT00000051244", "Q5BJ52", "ENSXETG00000012644" ] }, "reaction_10317981": { "compartment": "compartment_70101", "id": "reaction_10317981", "reactome": "R-XTR-426520", "name": "Endonucleolytic RISC hydrolyzes target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426523" ], "products": [ "species_426511" ], "modifiers": [ [ "species_10317970", "catalyst" ] ], "additional_components": [ "Q6DJB9", "ENSXETT00000051244" ] }, "reaction_10317978": { "compartment": "compartment_70101", "id": "reaction_10317978", "reactome": "R-XTR-426489", "name": "RISC binds inexactly matching target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317970", "species_10317974", "species_426515" ], "products": [ "species_10317976" ], "modifiers": [], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "ENSXETG00000030437", "A0A6I8RHW3", "ENSXETG00000030437", "Q6DJB9", "ENSXETT00000051244" ] }, "reaction_10316176": { "compartment": "compartment_70101", "id": "reaction_10316176", "reactome": "R-XTR-210805", "name": "Removal of miRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316164" ], "products": [ "species_10316174" ], "modifiers": [], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "A0A6I8S266", "ENSXETG00000036175", "Q5BJ52", "ENSXETG00000012644", "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175" ] }, "reaction_10325971": { "compartment": "compartment_70101", "id": "reaction_10325971", "reactome": "R-XTR-2106614", "name": "Duplex miRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325969" ], "products": [ "species_10316164" ], "modifiers": [], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "A0A6I8S266", "ENSXETG00000036175", "Q5BJ52", "ENSXETG00000012644", "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "A0A6I8S266", "ENSXETG00000036175", "Q5BJ52", "ENSXETG00000012644" ] }, "reaction_10329786": { "compartment": "compartment_70101", "id": "reaction_10329786", "reactome": "R-XTR-5578966", "name": "TNRC6A:AGO2:miRNA is transported into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329778" ], "products": [ "species_10329784" ], "modifiers": [], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "A0A6I8RHW3", "ENSXETG00000030437", "A0A6I8RHW3", "ENSXETG00000030437", "Q6DJB9", "ENSXETT00000051244" ] }, "reaction_10329780": { "compartment": "compartment_70101", "id": "reaction_10329780", "reactome": "R-XTR-5578965", "name": "TNRC6A binds AGO2:miRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317974", "species_10316168" ], "products": [ "species_10329778" ], "modifiers": [], "additional_components": [ "ENSXETG00000030437", "Q6DJB9", "ENSXETT00000051244", "Q6DJB9", "ENSXETT00000051244", "A0A6I8RHW3", "ENSXETG00000030437" ] }, "reaction_10316485": { "compartment": "compartment_7660", "id": "reaction_10316485", "reactome": "R-XTR-212252", "name": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316481", "species_10316457" ], "products": [ "species_10316483" ], "modifiers": [], "additional_components": [ "A0A6I8QJB3", "ENSXETG00000020362", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QJB3", "ENSXETG00000020362", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146" ] }, "reaction_10316517": { "compartment": "compartment_7660", "id": "reaction_10316517", "reactome": "R-XTR-212269", "name": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10316508" ], "products": [ "species_77502", "species_10316514" ], "modifiers": [ [ "species_10316508", "catalyst" ] ], "additional_components": [ "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146" ] }, "reaction_10316502": { "compartment": "compartment_7660", "id": "reaction_10316502", "reactome": "R-XTR-212263", "name": "PRC2 trimethylates histone H3 at lysine-27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10316483" ], "products": [ "species_77502", "species_10316499" ], "modifiers": [ [ "species_10316483", "catalyst" ] ], "additional_components": [ "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QJB3", "ENSXETG00000020362", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QJB3", "ENSXETG00000020362", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QJB3", "ENSXETG00000020362", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146" ] }, "reaction_10329316": { "compartment": "compartment_7660", "id": "reaction_10329316", "reactome": "R-XTR-5221061", "name": "TDG excises 5-carboxylcytosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5220996", "species_10312379" ], "products": [ "species_5221064", "species_10312409" ], "modifiers": [ [ "species_10312379", "catalyst" ] ], "additional_components": [ "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927", "ENSXETG00000025927" ] }, "reaction_10329314": { "compartment": "compartment_7660", "id": "reaction_10329314", "reactome": "R-XTR-5220959", "name": "TDG excises 5-formylcytosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5221062", "species_10312379" ], "products": [ "species_5221065", "species_10312409" ], "modifiers": [ [ "species_10312379", "catalyst" ] ], "additional_components": [ "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927", "ENSXETG00000025927" ] }, "reaction_10330834": { "compartment": "compartment_70101", "id": "reaction_10330834", "reactome": "R-XTR-5686315", "name": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312336" ], "products": [ "species_10312054", "species_10312334" ], "modifiers": [], "additional_components": [ "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387", "A0A6I8RAF1", "ENSXETG00000039550", "ENSXETG00000039550", "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10312039": { "compartment": "compartment_876", "id": "reaction_10312039", "reactome": "R-XTR-74734", "name": "Re-integration of insulin receptor into plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312037" ], "products": [ "species_10312021" ], "modifiers": [], "additional_components": [ "A0A6I8QUB9", "ENSXETG00000013518", "A0A6I8QUB9", "ENSXETG00000013518" ] }, "reaction_10322416": { "compartment": "compartment_876", "id": "reaction_10322416", "reactome": "R-XTR-1306957", "name": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10322413", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "A0A6I8RUB1", "ENSXETG00000007252" ] }, "reaction_10322418": { "compartment": "compartment_876", "id": "reaction_10322418", "reactome": "R-XTR-1306963", "name": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313814", "species_10322318" ], "products": [ "species_10322409" ], "modifiers": [], "additional_components": [ "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110" ] }, "reaction_10324487": { "compartment": "compartment_876", "id": "reaction_10324487", "reactome": "R-XTR-1963563", "name": "MATK (CSK homologous kinase) binds phosphorylated ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324483", "species_10322318" ], "products": [ "species_10324485" ], "modifiers": [], "additional_components": [ "ENSXETG00000032315", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "A0A6I8RYR6", "ENSXETG00000032315" ] }, "reaction_10335698": { "compartment": "compartment_876", "id": "reaction_10335698", "reactome": "R-XTR-8864125", "name": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335683", "species_29356" ], "products": [ "species_29372", "species_10335695" ], "modifiers": [ [ "species_10335683", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145" ] }, "reaction_10324503": { "compartment": "compartment_876", "id": "reaction_10324503", "reactome": "R-XTR-1963582", "name": "Trans-autophosphorylation of ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10324500" ], "products": [ "species_29370", "species_10322311" ], "modifiers": [ [ "species_10324500", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145" ] }, "reaction_10322327": { "compartment": "compartment_876", "id": "reaction_10322327", "reactome": "R-XTR-1250195", "name": "SHC1 phosphorylation by ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322320", "species_113592" ], "products": [ "species_29370", "species_10322324" ], "modifiers": [ [ "species_10322320", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145" ] }, "reaction_10332266": { "compartment": "compartment_70101", "id": "reaction_10332266", "reactome": "R-XTR-6785636", "name": "Phosphorylated ERBB2 heterodimers bind MEMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10332262", "species_10322318" ], "products": [ "species_10332264" ], "modifiers": [], "additional_components": [ "ENSXETT00000018710", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "Q6DJ03", "ENSXETT00000018710" ] }, "reaction_10324496": { "compartment": "compartment_876", "id": "reaction_10324496", "reactome": "R-XTR-1963581", "name": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10324493" ], "products": [ "species_29370", "species_10322316" ], "modifiers": [ [ "species_10324493", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145" ] }, "reaction_10322488": { "compartment": "compartment_70101", "id": "reaction_10322488", "reactome": "R-XTR-1433415", "name": "Activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317330", "species_29438" ], "products": [ "species_29420", "species_10312717" ], "modifiers": [ [ "species_10322485", "catalyst" ] ], "additional_components": [ "species_29420", "Q6GL60", "ENSXETT00000092508", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10312285": { "compartment": "compartment_876", "id": "reaction_10312285", "reactome": "R-XTR-83660", "name": "Membrane-anchored TNF-alpha binds TNFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312281", "species_10312271" ], "products": [ "species_10312279", "species_10312283" ], "modifiers": [], "additional_components": [ "F6X123", "ENSXETT00000023023", "A0A6I8PW21", "ENSXETG00000032118", "ENSXETT00000023023", "A0A6I8PW21", "ENSXETG00000032118" ] }, "reaction_10327781": { "compartment": "compartment_876", "id": "reaction_10327781", "reactome": "R-XTR-3371353", "name": "Soluble TNF-alpha binds TNFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327777", "species_10312281" ], "products": [ "species_10327779", "species_10312279" ], "modifiers": [], "additional_components": [ "F6X123", "ENSXETT00000023023", "A0A6I8PW21", "ENSXETG00000032118", "A0A6I8PW21", "ENSXETG00000032118", "ENSXETT00000023023" ] }, "reaction_10337807": { "compartment": "compartment_876", "id": "reaction_10337807", "reactome": "R-XTR-9624272", "name": "MMPs cleave HB-EGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337798" ], "products": [ "species_10337800", "species_10313836" ], "modifiers": [ [ "species_10337802", "catalyst" ], [ "species_10337805", "catalyst" ] ], "additional_components": [ "ENSXETG00000039798", "ENSXETG00000039798", "ENSXETG00000039798", "A0A6I8PRW9", "ENSXETG00000033700", "species_428203" ] }, "reaction_10337899": { "compartment": "compartment_7660", "id": "reaction_10337899", "reactome": "R-XTR-9632873", "name": "p-S10 CDKN1B translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337895" ], "products": [ "species_10337897" ], "modifiers": [], "additional_components": [ "ENSXETG00000038125", "ENSXETG00000038125" ] }, "reaction_10337824": { "compartment": "compartment_876", "id": "reaction_10337824", "reactome": "R-XTR-9625813", "name": "S1P binds S1PR3 in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5218688", "species_10317807" ], "products": [ "species_10337805" ], "modifiers": [], "additional_components": [ "ENSXETG00000033700", "A0A6I8PRW9", "ENSXETG00000033700", "species_428203" ] }, "reaction_10313536": { "compartment": "compartment_17957", "id": "reaction_10313536", "reactome": "R-XTR-174731", "name": "Degradation of newly synthesized ApoB-48", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313490" ], "products": [], "modifiers": [], "additional_components": [ "ENSXETG00000026768" ] }, "reaction_10335790": { "compartment": "compartment_17960", "id": "reaction_10335790", "reactome": "R-XTR-8866327", "name": "VLDL translocates from SER lumen to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335778" ], "products": [ "species_10335788" ], "modifiers": [], "additional_components": [ "species_171142", "species_171126", "species_216762", "species_163579", "A0A6I8RKY6", "ENSXETG00000026768", "species_171126", "A0A6I8RKY6", "ENSXETG00000026768", "species_163579", "species_171142", "species_216762" ] }, "reaction_10335786": { "compartment": "compartment_17960", "id": "reaction_10335786", "reactome": "R-XTR-8866308", "name": "pre-VLDL translocates from RER membrane to SER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335784" ], "products": [ "species_10335776" ], "modifiers": [], "additional_components": [ "species_171126", "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "species_171126" ] }, "reaction_10335780": { "compartment": "compartment_70101", "id": "reaction_10335780", "reactome": "R-XTR-8866304", "name": "pre-VLDL binds lipids to form VLDL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335776", "species_8866316", "species_8866305", "species_8866307", "species_8866324" ], "products": [ "species_10335778" ], "modifiers": [], "additional_components": [ "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "species_171126", "species_171142", "species_171126", "species_216762", "species_163579", "A0A6I8RKY6", "ENSXETG00000026768" ] }, "reaction_10330351": { "compartment": "compartment_70101", "id": "reaction_10330351", "reactome": "R-XTR-5661217", "name": "MT1A binds zinc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330347", "species_29426" ], "products": [ "species_10330349" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "species_29426", "A0A6I8RW79", "ENSXETG00000030675" ] }, "reaction_10330383": { "compartment": "compartment_70101", "id": "reaction_10330383", "reactome": "R-XTR-5662620", "name": "MT3 binds cadmium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1132098", "species_10330367" ], "products": [ "species_10330381" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "A0A6I8RW79", "ENSXETG00000030675", "species_1132098" ] }, "reaction_10330379": { "compartment": "compartment_70101", "id": "reaction_10330379", "reactome": "R-XTR-5662613", "name": "MT3 exchanges zinc for copper", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330369", "species_209799" ], "products": [ "species_10330377", "species_29426" ], "modifiers": [], "additional_components": [ "A0A6I8RW79", "ENSXETG00000030675", "species_29426", "A0A6I8RW79", "ENSXETG00000030675", "species_29426", "species_3299744" ] }, "reaction_10330375": { "compartment": "compartment_70101", "id": "reaction_10330375", "reactome": "R-XTR-5662608", "name": "MT2A binds cadmium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330347", "species_1132098" ], "products": [ "species_10330373" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "species_1132098", "A0A6I8RW79", "ENSXETG00000030675" ] }, "reaction_10330355": { "compartment": "compartment_70101", "id": "reaction_10330355", "reactome": "R-XTR-5661230", "name": "MT1A binds arsenic", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5661216", "species_10330347" ], "products": [ "species_10330353" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "A0A6I8RW79", "ENSXETG00000030675", "species_5661216" ] }, "reaction_10330387": { "compartment": "compartment_70101", "id": "reaction_10330387", "reactome": "R-XTR-5662986", "name": "MT2A binds copper", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330347", "species_3299744" ], "products": [ "species_10330385" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "species_3299744", "A0A6I8RW79", "ENSXETG00000030675" ] }, "reaction_10330371": { "compartment": "compartment_70101", "id": "reaction_10330371", "reactome": "R-XTR-5662606", "name": "MT3 binds zinc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426", "species_10330367" ], "products": [ "species_10330369" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "A0A6I8RW79", "ENSXETG00000030675", "species_29426" ] }, "reaction_10330863": { "compartment": "compartment_70101", "id": "reaction_10330863", "reactome": "R-XTR-5687107", "name": "MAPK4,6 translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330857" ], "products": [ "species_10330861" ], "modifiers": [], "additional_components": [ "A0A6I8RH21", "ENSXETG00000038723", "A0A6I8RH21", "ENSXETG00000038723" ] }, "reaction_10330849": { "compartment": "compartment_70101", "id": "reaction_10330849", "reactome": "R-XTR-5687086", "name": "PAK1,2,3 phosphorylates MAPK6,4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10330843" ], "products": [ "species_29370", "species_10330846" ], "modifiers": [ [ "species_10329598", "catalyst" ] ], "additional_components": [ "ENSXETG00000038723", "ENSXETG00000038723", "ENSXETG00000011808" ] }, "reaction_10338027": { "compartment": "compartment_12045", "id": "reaction_10338027", "reactome": "R-XTR-9653514", "name": "USP17L2 deubiquitinates RCE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10338022" ], "products": [ "species_10338024", "species_10331757" ], "modifiers": [ [ "species_10331547", "catalyst" ] ], "additional_components": [ "ENSXETT00000056088", "ENSXETT00000056088", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "ENSXETT00000015033" ] }, "reaction_10338001": { "compartment": "compartment_876", "id": "reaction_10338001", "reactome": "R-XTR-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10337997" ], "products": [ "species_10337999" ], "modifiers": [], "additional_components": [ "Q6GL10", "ENSXETT00000004138", "Q6DEY3", "ENSXETT00000057305", "Q6GL10", "ENSXETT00000004138", "Q6DEY3", "ENSXETT00000057305" ] }, "reaction_10330310": { "compartment": "compartment_876", "id": "reaction_10330310", "reactome": "R-XTR-5658438", "name": "SPRED dimer binds NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330297", "species_10330301" ], "products": [ "species_10330303" ], "modifiers": [], "additional_components": [ "Q66JG9", "ENSXETT00000039156", "ENSXETG00000021350", "A0A6I8R7X8", "ENSXETG00000021350", "Q66JG9", "ENSXETT00000039156" ] }, "reaction_10337357": { "compartment": "compartment_70101", "id": "reaction_10337357", "reactome": "R-XTR-9014294", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312723", "species_10337353" ], "products": [ "species_10337355" ], "modifiers": [], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "A0A6I8SQB3", "ENSXETG00000005314", "A0A6I8S090", "ENSXETG00000032218", "A0A6I8SQB3", "ENSXETG00000005314", "A0A6I8S090", "ENSXETG00000032218", "F7DEH8", "ENSXETT00000009928", "species_29438" ] }, "reaction_10337369": { "compartment": "compartment_876", "id": "reaction_10337369", "reactome": "R-XTR-9014420", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312723" ], "products": [ "species_10330417" ], "modifiers": [], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "F7DEH8", "ENSXETT00000009928", "species_29438" ] }, "reaction_10338297": { "compartment": "compartment_876", "id": "reaction_10338297", "reactome": "R-XTR-9714483", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312723" ], "products": [ "species_10338295" ], "modifiers": [], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "F7DEH8", "ENSXETT00000009928", "species_29438" ] }, "reaction_10337367": { "compartment": "compartment_70101", "id": "reaction_10337367", "reactome": "R-XTR-9014296", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10337351" ], "products": [ "species_10312723", "species_29420" ], "modifiers": [ [ "species_10337364", "catalyst" ] ], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29420", "F7DEH8", "ENSXETT00000009928", "species_29438", "A4II46", "ENSXETT00000074782", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10338289": { "compartment": "compartment_17906", "id": "reaction_10338289", "reactome": "R-XTR-9714477", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338279", "species_10338285" ], "products": [ "species_10338287" ], "modifiers": [], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "F7DEH8", "ENSXETT00000009928", "species_29438" ] }, "reaction_10338291": { "compartment": "compartment_876", "id": "reaction_10338291", "reactome": "R-XTR-9714480", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312723" ], "products": [ "species_10338279" ], "modifiers": [], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "F7DEH8", "ENSXETT00000009928", "species_29438" ] }, "reaction_10337362": { "compartment": "compartment_70101", "id": "reaction_10337362", "reactome": "R-XTR-9014295", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312723", "species_29356" ], "products": [ "species_29372", "species_10337351" ], "modifiers": [ [ "species_10337359", "catalyst" ] ], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "F7DEH8", "ENSXETT00000009928", "species_29420", "A0A6I8QIL4", "ENSXETG00000001985", "B5DFQ4", "ENSXETT00000003971" ] }, "reaction_10311975": { "compartment": "compartment_876", "id": "reaction_10311975", "reactome": "R-XTR-73945", "name": "FAS-mediated dimerization of procaspase-8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311969", "species_10311967" ], "products": [ "species_10311973" ], "modifiers": [], "additional_components": [ "A0A6I8Q0P2", "ENSXETG00000032748", "A0A6I8PTW1", "ENSXETG00000031916", "A0A6I8QWZ8", "ENSXETG00000041356", "ENSXETG00000032748", "A0A6I8PTW1", "ENSXETG00000031916", "A0A6I8QWZ8", "ENSXETG00000041356", "A0A6I8Q0P2", "ENSXETG00000032748" ] }, "reaction_10338303": { "compartment": "compartment_876", "id": "reaction_10338303", "reactome": "R-XTR-9714694", "name": "RAC3 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337426" ], "products": [ "species_10338301" ], "modifiers": [], "additional_components": [ "species_29438", "species_29438" ] }, "reaction_10337431": { "compartment": "compartment_876", "id": "reaction_10337431", "reactome": "R-XTR-9018806", "name": "RAC3 GAPs stimulate RAC3 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337426", "species_29356" ], "products": [ "species_10337424", "species_29372" ], "modifiers": [ [ "species_10337428", "catalyst" ] ], "additional_components": [ "species_29438", "species_29420", "A0A6I8QIL4", "ENSXETG00000001985", "B5DFQ4", "ENSXETT00000003971" ] }, "reaction_10337441": { "compartment": "compartment_876", "id": "reaction_10337441", "reactome": "R-XTR-9018807", "name": "RAC3 GDIs block activation of RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337424", "species_10337433" ], "products": [ "species_10337439" ], "modifiers": [], "additional_components": [ "species_29420", "species_29420" ] }, "reaction_10337386": { "compartment": "compartment_70101", "id": "reaction_10337386", "reactome": "R-XTR-9018745", "name": "RHOQ GAPs stimulate RHOQ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337379", "species_29356" ], "products": [ "species_29372", "species_10337381" ], "modifiers": [ [ "species_10337383", "catalyst" ] ], "additional_components": [ "F6ZQ78", "ENSXETT00000010273", "species_29438", "F6ZQ78", "ENSXETT00000010273", "species_29420", "A0A6I8QIL4", "ENSXETG00000001985", "A0A6I8T1P4", "ENSXETG00000005630", "B5DFQ4", "ENSXETT00000003971" ] }, "reaction_10337474": { "compartment": "compartment_876", "id": "reaction_10337474", "reactome": "R-XTR-9018836", "name": "RHOQ translocates to the Golgi-associated vesicle membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337379" ], "products": [ "species_10337472" ], "modifiers": [], "additional_components": [ "F6ZQ78", "ENSXETT00000010273", "species_29438", "F6ZQ78", "ENSXETT00000010273", "species_29438" ] }, "reaction_10337263": { "compartment": "compartment_70101", "id": "reaction_10337263", "reactome": "R-XTR-9013024", "name": "RHOB binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337259", "species_10317689" ], "products": [ "species_10337261" ], "modifiers": [], "additional_components": [ "A0A6I8R6D3", "ENSXETG00000006092", "A0A6I8SJ25", "ENSXETG00000017030", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8Q6H0", "ENSXETG00000023782", "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8R6D3", "ENSXETG00000006092", "A0A6I8SJ25", "ENSXETG00000017030", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8Q6H0", "ENSXETG00000023782" ] }, "reaction_10338159": { "compartment": "compartment_74700", "id": "reaction_10338159", "reactome": "R-XTR-9690493", "name": "RHOB binds effectors on endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338155", "species_10330399" ], "products": [ "species_10338157" ], "modifiers": [], "additional_components": [ "A0A6I8R8W7", "ENSXETG00000018271", "A0A6I8RD71", "ENSXETG00000018144", "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8R8W7", "ENSXETG00000018271", "A0A6I8RD71", "ENSXETG00000018144" ] }, "reaction_10337240": { "compartment": "compartment_70101", "id": "reaction_10337240", "reactome": "R-XTR-9013022", "name": "RHOB GAPs stimulate RHOB GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10317689" ], "products": [ "species_29372", "species_10337201" ], "modifiers": [ [ "species_10337237", "catalyst" ] ], "additional_components": [ "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29420", "A0A6I8QIL4", "ENSXETG00000001985", "A4II46", "ENSXETT00000074782", "A0A6I8T1P4", "ENSXETG00000005630", "B5DFQ4", "ENSXETT00000003971" ] }, "reaction_10337243": { "compartment": "compartment_876", "id": "reaction_10337243", "reactome": "R-XTR-9013023", "name": "RHOB GEFs activate RHOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10337201" ], "products": [ "species_29420", "species_10317689" ], "modifiers": [ [ "species_10316060", "catalyst" ] ], "additional_components": [ "Q6NVL3", "ENSXETT00000056231", "species_29420", "Q6NVL3", "ENSXETT00000056231", "species_29438", "ENSXETG00000038787" ] }, "reaction_10337211": { "compartment": "compartment_70101", "id": "reaction_10337211", "reactome": "R-XTR-9013021", "name": "GDIs block activation of RHOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337201", "species_10337205" ], "products": [ "species_10337209" ], "modifiers": [], "additional_components": [ "Q6NVL3", "ENSXETT00000056231", "species_29420", "ENSXETT00000020510", "F7D6Y2", "ENSXETT00000020510", "Q6NVL3", "ENSXETT00000056231", "species_29420" ] }, "reaction_10338161": { "compartment": "compartment_876", "id": "reaction_10338161", "reactome": "R-XTR-9690494", "name": "RHOB translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317689" ], "products": [ "species_10330399" ], "modifiers": [], "additional_components": [ "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438" ] }, "reaction_10337468": { "compartment": "compartment_70101", "id": "reaction_10337468", "reactome": "R-XTR-9018826", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10337449" ], "products": [ "species_29372", "species_10337465" ], "modifiers": [ [ "species_10337449", "catalyst" ] ], "additional_components": [ "Q6DIS1", "ENSXETT00000007838", "species_29438", "Q6DIS1", "ENSXETT00000007838", "species_29420", "Q6DIS1", "ENSXETT00000007838", "species_29438" ] }, "reaction_10337463": { "compartment": "compartment_70101", "id": "reaction_10337463", "reactome": "R-XTR-9018824", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337459", "species_10337449" ], "products": [ "species_10337461" ], "modifiers": [], "additional_components": [ "A0A6I8RC59", "ENSXETG00000013857", "A0A6I8RIZ7", "ENSXETG00000032904", "Q6DIS1", "ENSXETT00000007838", "species_29438", "Q6DIS1", "ENSXETT00000007838", "species_29438", "A0A6I8RC59", "ENSXETG00000013857", "A0A6I8RIZ7", "ENSXETG00000032904" ] }, "reaction_10329821": { "compartment": "compartment_984", "id": "reaction_10329821", "reactome": "R-XTR-5607023", "name": "factor IXa associates with cell membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312873" ], "products": [ "species_10312962" ], "modifiers": [], "additional_components": [ "Q5M8Y0", "ENSXETT00000025939", "Q5M8Y0", "ENSXETT00000025939" ] }, "reaction_10312988": { "compartment": "compartment_984", "id": "reaction_10312988", "reactome": "R-XTR-158340", "name": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312984", "species_10312972" ], "products": [ "species_10312986" ], "modifiers": [], "additional_components": [ "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942", "A0A6I8S6I3", "ENSXETG00000005867", "A0A6I8S6I3", "ENSXETG00000005867", "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942" ] }, "reaction_10329823": { "compartment": "compartment_984", "id": "reaction_10329823", "reactome": "R-XTR-5607043", "name": "factor VIIIa associates with cell membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312938" ], "products": [ "species_10312956" ], "modifiers": [], "additional_components": [ "A0A6I8SC83", "ENSXETG00000038196", "A0A6I8SC83", "ENSXETG00000038196" ] }, "reaction_10338059": { "compartment": "compartment_17957", "id": "reaction_10338059", "reactome": "R-XTR-9670673", "name": "FIX is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338057" ], "products": [ "species_10312867" ], "modifiers": [], "additional_components": [ "ENSXETT00000025939", "ENSXETT00000025939" ] }, "reaction_10338055": { "compartment": "compartment_984", "id": "reaction_10338055", "reactome": "R-XTR-9670014", "name": "Factor VIIIa dissociates ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312938" ], "products": [ "species_10312934", "species_10338053" ], "modifiers": [], "additional_components": [ "A0A6I8SC83", "ENSXETG00000038196", "ENSXETG00000038196", "A0A6I8SC83", "ENSXETG00000038196" ] }, "reaction_10312966": { "compartment": "compartment_984", "id": "reaction_10312966", "reactome": "R-XTR-158278", "name": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312962", "species_10312956" ], "products": [ "species_10312964" ], "modifiers": [ [ "species_74112", "catalyst" ] ], "additional_components": [ "Q5M8Y0", "ENSXETT00000025939", "A0A6I8SC83", "ENSXETG00000038196", "A0A6I8SC83", "ENSXETG00000038196", "Q5M8Y0", "ENSXETT00000025939" ] }, "reaction_10338033": { "compartment": "compartment_17957", "id": "reaction_10338033", "reactome": "R-XTR-9661625", "name": "FVIII is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331360" ], "products": [ "species_10312922" ], "modifiers": [], "additional_components": [ "ENSXETG00000038196", "A0A6I8SC83", "ENSXETG00000038196" ] }, "reaction_10312930": { "compartment": "compartment_984", "id": "reaction_10312930", "reactome": "R-XTR-158118", "name": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312922", "species_10312926" ], "products": [ "species_10312928" ], "modifiers": [], "additional_components": [ "A0A6I8SC83", "ENSXETG00000038196", "F6TMK5", "ENSXETT00000046700", "F6TMK5", "ENSXETT00000046700", "A0A6I8SC83", "ENSXETG00000038196" ] }, "reaction_10330109": { "compartment": "compartment_5263228", "id": "reaction_10330109", "reactome": "R-XTR-5635843", "name": "GLI translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330107" ], "products": [ "species_10330101" ], "modifiers": [], "additional_components": [ "ENSXETG00000036606", "ENSXETG00000036606" ] }, "reaction_10330074": { "compartment": "compartment_261122", "id": "reaction_10330074", "reactome": "R-XTR-5632677", "name": "PTCH is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330070" ], "products": [ "species_10330072" ], "modifiers": [], "additional_components": [ "ENSXETG00000014834", "ENSXETG00000014834" ] }, "reaction_10330132": { "compartment": "compartment_7660", "id": "reaction_10330132", "reactome": "R-XTR-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330129", "species_10327687" ], "products": [ "species_10330125" ], "modifiers": [ [ "species_10330129", "catalyst" ] ], "additional_components": [ "A4IHP4", "ENSXETT00000017945", "Q6P8B3", "ENSXETT00000057841", "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A4IHP4", "ENSXETT00000017945", "Q6P8B3", "ENSXETT00000057841", "A0A6I8S0I4", "ENSXETG00000035313", "A4IHP4", "ENSXETT00000017945", "Q6P8B3", "ENSXETT00000057841", "A0A6I8S0I4", "ENSXETG00000035313" ] }, "reaction_10330098": { "compartment": "compartment_261122", "id": "reaction_10330098", "reactome": "R-XTR-5635102", "name": "GPR161 is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329842" ], "products": [ "species_10330096" ], "modifiers": [], "additional_components": [ "ENSXETG00000002410", "ENSXETG00000002410" ] }, "reaction_10329881": { "compartment": "compartment_20699", "id": "reaction_10329881", "reactome": "R-XTR-5617828", "name": "TRIP11:IFT20 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329879" ], "products": [ "species_10329873", "species_10329877" ], "modifiers": [], "additional_components": [ "A0A6I8SZZ2", "ENSXETG00000015833", "Q66KL7", "ENSXETT00000069320", "ENSXETT00000069320", "ENSXETG00000015833" ] }, "reaction_10321867": { "compartment": "compartment_70101", "id": "reaction_10321867", "reactome": "R-XTR-1183128", "name": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1183111" ], "products": [ "species_29382", "species_1183191" ], "modifiers": [ [ "species_10321864", "catalyst" ] ], "additional_components": [ "species_74112", "F6YPC2", "ENSXETT00000038130" ] }, "reaction_10328860": { "compartment": "compartment_7660", "id": "reaction_10328860", "reactome": "R-XTR-4722133", "name": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328853", "species_113671", "species_113685" ], "products": [ "species_29478", "species_10327320", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328857", "catalyst" ] ], "additional_components": [ "ENSXETT00000070583" ] }, "reaction_10327327": { "compartment": "compartment_7660", "id": "reaction_10327327", "reactome": "R-XTR-3214912", "name": "KDM1A, KDM1B demethylate MeK5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327318" ], "products": [ "species_29478", "species_10327320" ], "modifiers": [ [ "species_10327324", "catalyst" ] ], "additional_components": [ "ENSXETG00000015429" ] }, "reaction_10328879": { "compartment": "compartment_7660", "id": "reaction_10328879", "reactome": "R-XTR-4724284", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328864", "species_113671", "species_113685" ], "products": [ "species_29478", "species_10327320", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328876", "catalyst" ] ], "additional_components": [ "Q08D35", "ENSXETG00000002669", "A0A6I8Q587", "ENSXETG00000006700" ] }, "reaction_10330334": { "compartment": "compartment_7660", "id": "reaction_10330334", "reactome": "R-XTR-5661121", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10330190" ], "products": [ "species_10328898", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328914", "catalyst" ] ], "additional_components": [ "A0A6I8S4K7", "ENSXETG00000004822", "Q08D35", "ENSXETG00000002669" ] }, "reaction_10328890": { "compartment": "compartment_7660", "id": "reaction_10328890", "reactome": "R-XTR-4754181", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328881", "species_113671", "species_113685" ], "products": [ "species_10327318", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328885", "catalyst" ] ], "additional_components": [ "ENSXETT00000007540" ] }, "reaction_10328917": { "compartment": "compartment_7660", "id": "reaction_10328917", "reactome": "R-XTR-4754187", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328898", "species_113671", "species_113685" ], "products": [ "species_10328906", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328914", "catalyst" ] ], "additional_components": [ "A0A6I8S4K7", "ENSXETG00000004822", "Q08D35", "ENSXETG00000002669" ] }, "reaction_10330324": { "compartment": "compartment_7660", "id": "reaction_10330324", "reactome": "R-XTR-5661116", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329431", "species_113671", "species_113685" ], "products": [ "species_10328881", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328885", "catalyst" ] ], "additional_components": [ "ENSXETT00000007540" ] }, "reaction_10330320": { "compartment": "compartment_7660", "id": "reaction_10330320", "reactome": "R-XTR-5661114", "name": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330145", "species_113671", "species_113685" ], "products": [ "species_10328853", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328857", "catalyst" ] ], "additional_components": [ "ENSXETT00000070583" ] }, "reaction_10330338": { "compartment": "compartment_7660", "id": "reaction_10330338", "reactome": "R-XTR-5661123", "name": "KDM1A, KDM1B demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328881" ], "products": [ "species_10327318", "species_29478" ], "modifiers": [ [ "species_10327324", "catalyst" ] ], "additional_components": [ "ENSXETG00000015429" ] }, "reaction_10330322": { "compartment": "compartment_7660", "id": "reaction_10330322", "reactome": "R-XTR-5661115", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10328862" ], "products": [ "species_10328864", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328876", "catalyst" ] ], "additional_components": [ "Q08D35", "ENSXETG00000002669", "A0A6I8Q587", "ENSXETG00000006700" ] }, "reaction_10327428": { "compartment": "compartment_7660", "id": "reaction_10327428", "reactome": "R-XTR-3247569", "name": "PADI4 deiminates Histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10327386" ], "products": [ "species_76230", "species_10327417" ], "modifiers": [ [ "species_10327419", "catalyst" ] ], "additional_components": [ "ENSXETT00000038130" ] }, "reaction_10329663": { "compartment": "compartment_7660", "id": "reaction_10329663", "reactome": "R-XTR-5423038", "name": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313794", "species_77087" ], "products": [ "species_77502", "species_10326319" ], "modifiers": [ [ "species_10326655", "catalyst" ] ], "additional_components": [ "ENSXETG00000035354", "ENSXETG00000035354", "ENSXETT00000012803" ] }, "reaction_10330137": { "compartment": "compartment_7660", "id": "reaction_10330137", "reactome": "R-XTR-5637686", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10327318" ], "products": [ "species_77502", "species_10328881" ], "modifiers": [ [ "species_10330134", "catalyst" ] ], "additional_components": [ "B7ZUF3", "ENSXETT00000065894", "A0A6I8S8Z5", "ENSXETG00000040375" ] }, "reaction_10335723": { "compartment": "compartment_7660", "id": "reaction_10335723", "reactome": "R-XTR-8865237", "name": "SETD6 methylates RELA in the NFkB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10313349" ], "products": [ "species_77502", "species_10335716" ], "modifiers": [ [ "species_10335720", "catalyst" ] ], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "ENSXETG00000013793" ] }, "reaction_10329450": { "compartment": "compartment_7660", "id": "reaction_10329450", "reactome": "R-XTR-5244692", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10328881" ], "products": [ "species_77502", "species_10329431" ], "modifiers": [ [ "species_10329447", "catalyst" ], [ "species_10329122", "inhibitor" ] ], "additional_components": [ "A0A6I8S8Z5", "ENSXETG00000040375", "A0A6I8RD53", "ENSXETG00000039708", "A0A6I8SUP9", "ENSXETG00000037286" ] }, "reaction_10328986": { "compartment": "compartment_7660", "id": "reaction_10328986", "reactome": "R-XTR-4827382", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10328862" ], "products": [ "species_77502", "species_10328969" ], "modifiers": [ [ "species_10328983", "catalyst" ] ], "additional_components": [ "Q28CQ7", "ENSXETG00000005401", "A4IGY9", "ENSXETG00000015666", "Q08D57", "ENSXETG00000003760" ] }, "reaction_10328999": { "compartment": "compartment_7660", "id": "reaction_10328999", "reactome": "R-XTR-5159245", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10327320" ], "products": [ "species_77502", "species_10327318" ], "modifiers": [ [ "species_10328996", "catalyst" ] ], "additional_components": [ "B7ZUF3", "ENSXETT00000065894", "Q4QQN5", "ENSXETT00000036910" ] }, "reaction_10314063": { "compartment": "compartment_876", "id": "reaction_10314063", "reactome": "R-XTR-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10314060", "catalyst" ] ], "additional_components": [ "ENSXETT00000048392" ] }, "reaction_10336095": { "compartment": "compartment_876", "id": "reaction_10336095", "reactome": "R-XTR-8932955", "name": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189227", "species_74113" ], "products": [ "species_83910", "species_189254" ], "modifiers": [ [ "species_10336092", "catalyst" ] ], "additional_components": [ "species_188995", "species_70113", "species_70113", "species_188995", "ENSXETG00000036486" ] }, "reaction_10317056": { "compartment": "compartment_876", "id": "reaction_10317056", "reactome": "R-XTR-376122", "name": "DSCAM/DSCAML1 homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317052" ], "products": [ "species_10317054" ], "modifiers": [], "additional_components": [ "ENSXETG00000003741", "A0A6I8S5X4", "ENSXETG00000003741" ] }, "reaction_10322283": { "compartment": "compartment_70101", "id": "reaction_10322283", "reactome": "R-XTR-1237325", "name": "Hemoglobin A is protonated and carbamated causing release of oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113528", "species_10322261" ], "products": [ "species_29368", "species_10322281" ], "modifiers": [], "additional_components": [ "species_189444", "P07428", "ENSXETT00000002494", "species_113533", "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566", "species_189444", "P07428", "ENSXETT00000002494", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627" ] }, "reaction_10334487": { "compartment": "compartment_70101", "id": "reaction_10334487", "reactome": "R-XTR-6806831", "name": "CYB5Rs reduce MetHb to HbA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334462", "species_73473" ], "products": [ "species_70106", "species_10334468", "species_29360" ], "modifiers": [ [ "species_10334484", "catalyst" ] ], "additional_components": [ "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566", "species_917955", "P07428", "ENSXETT00000002494", "species_189444", "P07428", "ENSXETT00000002494", "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566", "Q5BJ68", "ENSXETT00000096157", "A0A6I8SMQ8", "ENSXETG00000035257", "Q28CZ9", "ENSXETG00000022592" ] }, "reaction_10322214": { "compartment": "compartment_984", "id": "reaction_10322214", "reactome": "R-XTR-1237047", "name": "CA4:Zn2+ hydrates CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10322211", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8QID1", "ENSXETG00000034545" ] }, "reaction_10335965": { "compartment": "compartment_171907", "id": "reaction_10335965", "reactome": "R-XTR-8876366", "name": "LDL translocates from endosome lumen to lysosome lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335963" ], "products": [ "species_10335734" ], "modifiers": [], "additional_components": [ "species_163579", "A0A6I8RKY6", "ENSXETG00000026768", "species_216762", "species_171126", "species_171142", "species_171126", "species_171142", "species_163579", "species_216762", "A0A6I8RKY6", "ENSXETG00000026768" ] }, "reaction_10335741": { "compartment": "compartment_161320", "id": "reaction_10335741", "reactome": "R-XTR-8865667", "name": "LIPA hydrolyses sterol esters to sterols and fatty acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_10335734" ], "products": [ "species_8848047", "species_10335736", "species_8865666" ], "modifiers": [ [ "species_10335738", "catalyst" ] ], "additional_components": [ "species_171126", "species_171142", "species_163579", "species_216762", "A0A6I8RKY6", "ENSXETG00000026768", "species_171126", "species_171142", "species_216762", "A0A6I8RKY6", "ENSXETG00000026768", "ENSXETT00000020371" ] }, "reaction_10334653": { "compartment": "compartment_70101", "id": "reaction_10334653", "reactome": "R-XTR-6813720", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10334650", "catalyst" ] ], "additional_components": [ "ENSXETG00000038694" ] }, "reaction_10335991": { "compartment": "compartment_12045", "id": "reaction_10335991", "reactome": "R-XTR-8876696", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384", "species_1500578" ], "products": [ "species_8876704", "species_76194" ], "modifiers": [ [ "species_10335988", "catalyst" ] ], "additional_components": [ "ENSXETG00000034253" ] }, "reaction_10335379": { "compartment": "compartment_876", "id": "reaction_10335379", "reactome": "R-XTR-8858252", "name": "HDLBP binds HDL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316656", "species_10335375" ], "products": [ "species_10335377" ], "modifiers": [], "additional_components": [ "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "species_171142", "species_216762", "ENSXETG00000012164", "A0A6I8S7E7", "ENSXETG00000012164", "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "species_171142", "species_216762" ] }, "reaction_10317284": { "compartment": "compartment_17947", "id": "reaction_10317284", "reactome": "R-XTR-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_382577" ], "products": [ "species_382571", "species_29372", "species_29370" ], "modifiers": [ [ "species_10317281", "catalyst" ] ], "additional_components": [ "A0A6I8Q353", "ENSXETG00000007705" ] }, "reaction_10322479": { "compartment": "compartment_17906", "id": "reaction_10322479", "reactome": "R-XTR-1369065", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1369066", "species_29356", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1369027" ], "modifiers": [ [ "species_10322476", "catalyst" ] ], "additional_components": [ "Q08D64", "ENSXETT00000030397" ] }, "reaction_10318119": { "compartment": "compartment_876", "id": "reaction_10318119", "reactome": "R-XTR-429094", "name": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10318116", "catalyst" ] ], "additional_components": [ "ENSXETT00000007515" ] }, "reaction_10335959": { "compartment": "compartment_70101", "id": "reaction_10335959", "reactome": "R-XTR-8876319", "name": "SLC50A1 transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10335956", "catalyst" ] ], "additional_components": [ "ENSXETG00000019427" ] }, "reaction_10318099": { "compartment": "compartment_876", "id": "reaction_10318099", "reactome": "R-XTR-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10318096", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_70113", "species_29532", "ENSXETT00000048392" ] }, "reaction_10318281": { "compartment": "compartment_876", "id": "reaction_10318281", "reactome": "R-XTR-442368", "name": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71067" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10318278", "catalyst" ] ], "additional_components": [ "A0A6I8SBF5", "ENSXETG00000041263", "CHEBI:28694", "F7EFD4", "ENSXETT00000006578" ] }, "reaction_10318333": { "compartment": "compartment_876", "id": "reaction_10318333", "reactome": "R-XTR-444160", "name": "VMAT1/2 can mediate the transport of biogenic amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444154" ], "products": [ "species_444152" ], "modifiers": [ [ "species_10318330", "catalyst" ] ], "additional_components": [ "species_351601", "CHEBI:28918", "species_114523", "species_390899", "CHEBI:18357", "CHEBI:18357", "CHEBI:28918", "species_390899", "species_351601", "species_114523", "F6YMA0", "ENSXETT00000019549", "A0A6I8R508", "ENSXETG00000038313" ] }, "reaction_10318203": { "compartment": "compartment_876", "id": "reaction_10318203", "reactome": "R-XTR-434650", "name": "MATEs mediate extrusion of xenobiotics", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_446589" ], "products": [ "species_70106", "species_446597" ], "modifiers": [ [ "species_10318200", "catalyst" ] ], "additional_components": [ "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:6801", "CHEBI:16737", "CHEBI:8428", "CHEBI:42820", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "CHEBI:6801", "A4IIS8", "ENSXETG00000022931", "A0A6I8STL3", "ENSXETG00000039254" ] }, "reaction_10319068": { "compartment": "compartment_876", "id": "reaction_10319068", "reactome": "R-XTR-561253", "name": "SLC22A12 exchanges extracellular urate for cytosolic LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_429056" ], "products": [ "species_373863", "species_30034" ], "modifiers": [ [ "species_10319065", "catalyst" ] ], "additional_components": [ "ENSXETG00000023239" ] }, "reaction_10319063": { "compartment": "compartment_876", "id": "reaction_10319063", "reactome": "R-XTR-561059", "name": "OAT2 and OAT4 mediate transport of sulphate conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561071" ], "products": [ "species_561062", "species_561075" ], "modifiers": [ [ "species_10319060", "catalyst" ] ], "additional_components": [ "species_176496", "species_176501", "species_176501", "species_176496", "ENSXETG00000023239" ] }, "reaction_10319058": { "compartment": "compartment_876", "id": "reaction_10319058", "reactome": "R-XTR-561041", "name": "OAT1-3 transport organic anions with antiport of dicarboxylic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561049" ], "products": [ "species_561078", "species_561075" ], "modifiers": [ [ "species_10319055", "catalyst" ] ], "additional_components": [ "CHEBI:104011", "CHEBI:2453", "CHEBI:2453", "CHEBI:104011", "A0A6I8QMN4", "ENSXETG00000035704", "A0A6I8RMY7", "ENSXETG00000023239" ] }, "reaction_10318169": { "compartment": "compartment_876", "id": "reaction_10318169", "reactome": "R-XTR-433099", "name": "NaS2 co-transports sulphate and two sodium ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_83910", "species_174375" ], "modifiers": [ [ "species_10318166", "catalyst" ] ], "additional_components": [ "ENSXETG00000010608" ] }, "reaction_10320605": { "compartment": "compartment_947586", "id": "reaction_10320605", "reactome": "R-XTR-917839", "name": "apo-Transferrin dissociates from the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320599" ], "products": [ "species_10318912", "species_10320572" ], "modifiers": [], "additional_components": [ "A0A6I8QZE2", "ENSXETG00000040690", "Q501K5", "ENSXETG00000011814", "ENSXETG00000011814", "A0A6I8QZE2", "ENSXETG00000040690" ] }, "reaction_10320588": { "compartment": "compartment_876", "id": "reaction_10320588", "reactome": "R-XTR-917807", "name": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320576" ], "products": [ "species_10320586" ], "modifiers": [], "additional_components": [ "A0A6I8QZE2", "ENSXETG00000040690", "species_912516", "Q501K5", "ENSXETG00000011814", "species_912516", "Q501K5", "ENSXETG00000011814", "A0A6I8QZE2", "ENSXETG00000040690" ] }, "reaction_10320601": { "compartment": "compartment_70101", "id": "reaction_10320601", "reactome": "R-XTR-917814", "name": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320597" ], "products": [ "species_10320599" ], "modifiers": [], "additional_components": [ "A0A6I8QZE2", "ENSXETG00000040690", "Q501K5", "ENSXETG00000011814", "A0A6I8QZE2", "ENSXETG00000040690", "Q501K5", "ENSXETG00000011814" ] }, "reaction_10320603": { "compartment": "compartment_171907", "id": "reaction_10320603", "reactome": "R-XTR-917835", "name": "Fe3+ dissociates from holoTF:TFRC dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320586" ], "products": [ "species_10320597", "species_917966" ], "modifiers": [], "additional_components": [ "species_912516", "Q501K5", "ENSXETG00000011814", "A0A6I8QZE2", "ENSXETG00000040690", "A0A6I8QZE2", "ENSXETG00000040690", "Q501K5", "ENSXETG00000011814" ] }, "reaction_10320612": { "compartment": "compartment_984", "id": "reaction_10320612", "reactome": "R-XTR-917987", "name": "TFRC dimer binds 2xholoTF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320574", "species_10320572" ], "products": [ "species_10320576" ], "modifiers": [], "additional_components": [ "species_912516", "Q501K5", "ENSXETG00000011814", "A0A6I8QZE2", "ENSXETG00000040690", "A0A6I8QZE2", "ENSXETG00000040690", "species_912516", "Q501K5", "ENSXETG00000011814" ] }, "reaction_10331142": { "compartment": "compartment_876", "id": "reaction_10331142", "reactome": "R-XTR-5691154", "name": "HFE binds TFRC dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331138", "species_10320572" ], "products": [ "species_10331140" ], "modifiers": [], "additional_components": [ "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8QZE2", "ENSXETG00000040690", "A0A6I8QZE2", "ENSXETG00000040690", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8PKL5", "ENSXETG00000033834" ] }, "reaction_10320595": { "compartment": "compartment_171907", "id": "reaction_10320595", "reactome": "R-XTR-917811", "name": "STEAP3-like proteins reduce Fe3+ to Fe2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917882", "species_917966" ], "products": [ "species_917810" ], "modifiers": [ [ "species_10320592", "catalyst" ] ], "additional_components": [ "ENSXETT00000016208" ] }, "reaction_10331101": { "compartment": "compartment_70101", "id": "reaction_10331101", "reactome": "R-XTR-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690881", "species_10331097" ], "products": [ "species_10331099" ], "modifiers": [], "additional_components": [ "ENSXETG00000009184", "A0A6I8SX09", "ENSXETG00000009184" ] }, "reaction_10331117": { "compartment": "compartment_5460", "id": "reaction_10331117", "reactome": "R-XTR-5691107", "name": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113531", "species_113529" ], "products": [ "species_5691135" ], "modifiers": [ [ "species_10331114", "catalyst" ] ], "additional_components": [ "F6T7W4", "ENSXETT00000045926" ] }, "reaction_10320607": { "compartment": "compartment_984", "id": "reaction_10320607", "reactome": "R-XTR-917888", "name": "apoTF binds 2Fe3+ to form holoTF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318912", "species_912516" ], "products": [ "species_10320574" ], "modifiers": [], "additional_components": [ "ENSXETG00000011814", "species_912516", "Q501K5", "ENSXETG00000011814" ] }, "reaction_10320566": { "compartment": "compartment_984", "id": "reaction_10320566", "reactome": "R-XTR-917805", "name": "CYBRD1:Heme reduces Fe3+ to Fe2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917828", "species_912516" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10320563", "catalyst" ] ], "additional_components": [ "species_189444", "Q5CZL8", "ENSXETT00000040828" ] }, "reaction_10331110": { "compartment": "compartment_70101", "id": "reaction_10331110", "reactome": "R-XTR-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10331099", "catalyst" ] ], "additional_components": [ "A0A6I8SX09", "ENSXETG00000009184" ] }, "reaction_10320610": { "compartment": "compartment_947586", "id": "reaction_10320610", "reactome": "R-XTR-917933", "name": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347", "species_352327" ], "products": [ "species_109276", "species_912516" ], "modifiers": [ [ "species_10318278", "catalyst" ] ], "additional_components": [ "A0A6I8SBF5", "ENSXETG00000041263", "CHEBI:28694", "F7EFD4", "ENSXETT00000006578" ] }, "reaction_10323458": { "compartment": "compartment_70101", "id": "reaction_10323458", "reactome": "R-XTR-1562626", "name": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71067", "species_29368" ], "products": [ "species_5691103" ], "modifiers": [ [ "species_10323455", "catalyst" ] ], "additional_components": [ "F6T7W4", "ENSXETT00000045926" ] }, "reaction_10320671": { "compartment": "compartment_876", "id": "reaction_10320671", "reactome": "R-XTR-936897", "name": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_29356", "species_113592", "species_83910" ], "products": [ "species_29372", "species_29804", "species_29370", "species_74113" ], "modifiers": [ [ "species_10320666", "catalyst" ], [ "species_10320669", "inhibitor" ] ], "additional_components": [ "Q6P617", "ENSXETT00000095333", "A0A6I8QKL0", "ENSXETG00000020366", "A0A6I8S802", "ENSXETG00000038243", "Q6P617", "ENSXETT00000095333", "A0A6I8QKL0", "ENSXETG00000020366", "A0A6I8S802", "ENSXETG00000038243" ] }, "reaction_10338110": { "compartment": "compartment_984", "id": "reaction_10338110", "reactome": "R-XTR-9684068", "name": "ATP1A:ATP1B:FXYD binds cardiac glycosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9684063", "species_10320666" ], "products": [ "species_10320669" ], "modifiers": [], "additional_components": [ "Q6P617", "ENSXETT00000095333", "A0A6I8QKL0", "ENSXETG00000020366", "A0A6I8S802", "ENSXETG00000038243", "Q6P617", "ENSXETT00000095333", "A0A6I8QKL0", "ENSXETG00000020366", "A0A6I8S802", "ENSXETG00000038243" ] }, "reaction_10329512": { "compartment": "compartment_70101", "id": "reaction_10329512", "reactome": "R-XTR-5251989", "name": "ATP13A4,5 transport divalent ions from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5252122", "species_113592" ], "products": [ "species_29372", "species_29370", "species_5252016" ], "modifiers": [ [ "species_10329509", "catalyst" ] ], "additional_components": [ "F7C820", "ENSXETT00000003028", "A0A6I8R4Z6", "ENSXETG00000034939" ] }, "reaction_10320699": { "compartment": "compartment_876", "id": "reaction_10320699", "reactome": "R-XTR-939763", "name": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_947594" ], "products": [ "species_29372", "species_29370", "species_947588" ], "modifiers": [ [ "species_10320696", "catalyst" ] ], "additional_components": [ "species_8959490", "species_33625", "species_33625", "species_8959490", "Q5BL50", "ENSXETG00000020878" ] }, "reaction_10318054": { "compartment": "compartment_12045", "id": "reaction_10318054", "reactome": "R-XTR-427910", "name": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_74016" ], "products": [ "species_70106", "species_111875" ], "modifiers": [ [ "species_10318040", "catalyst" ], [ "species_10318052", "catalyst" ], [ "species_10318047", "inhibitor" ] ], "additional_components": [ "A0A6I8RIR9", "ENSXETG00000009695", "A0A6I8Q1N1", "ENSXETG00000002512", "A0A6I8ST89", "ENSXETG00000036412", "A0A6I8ST89", "ENSXETG00000036412" ] }, "reaction_10329566": { "compartment": "compartment_70101", "id": "reaction_10329566", "reactome": "R-XTR-5336466", "name": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29926" ], "products": [ "species_109496" ], "modifiers": [ [ "species_10329563", "catalyst" ] ], "additional_components": [ "ENSXETG00000021985" ] }, "reaction_10337028": { "compartment": "compartment_70101", "id": "reaction_10337028", "reactome": "R-XTR-8981621", "name": "Neuroglobin:oxygen dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337024" ], "products": [ "species_29368", "species_10337022" ], "modifiers": [], "additional_components": [ "species_189444", "Q575T7", "ENSXETT00000083304", "species_113533", "species_189444", "Q575T7", "ENSXETT00000083304" ] }, "reaction_10337063": { "compartment": "compartment_70101", "id": "reaction_10337063", "reactome": "R-XTR-8982617", "name": "CYGB:O2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329583" ], "products": [ "species_29368", "species_10329581" ], "modifiers": [], "additional_components": [ "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_113533", "species_189444", "Q6DEW1", "ENSXETT00000093870" ] }, "reaction_10337026": { "compartment": "compartment_70101", "id": "reaction_10337026", "reactome": "R-XTR-8981610", "name": "Neuroglobin binds oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_10337022" ], "products": [ "species_10337024" ], "modifiers": [], "additional_components": [ "species_189444", "Q575T7", "ENSXETT00000083304", "species_189444", "Q575T7", "ENSXETT00000083304", "species_113533" ] }, "reaction_10329738": { "compartment": "compartment_70101", "id": "reaction_10329738", "reactome": "R-XTR-5577050", "name": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10329735", "catalyst" ] ], "additional_components": [ "A0A6I8SN44", "ENSXETG00000041349", "A0A6I8Q2V9", "ENSXETG00000032386", "A0A6I8SMY0", "ENSXETG00000003440", "A0A6I8Q0D6", "ENSXETG00000034068" ] }, "reaction_10329869": { "compartment": "compartment_70101", "id": "reaction_10329869", "reactome": "R-XTR-5615668", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10314206", "catalyst" ] ], "additional_components": [ "A0A6I8R8Y6", "ENSXETG00000040684", "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10329660": { "compartment": "compartment_70101", "id": "reaction_10329660", "reactome": "R-XTR-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10329657", "catalyst" ] ], "additional_components": [ "A0A6I8RYK1", "ENSXETG00000032351", "species_29426", "F6YU63", "ENSXETT00000024409", "F7DZV1", "ENSXETT00000020485", "A0A6I8PVR9", "ENSXETG00000032433" ] }, "reaction_10329646": { "compartment": "compartment_70101", "id": "reaction_10329646", "reactome": "R-XTR-5362518", "name": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10329643", "catalyst" ] ], "additional_components": [ "A0A6I8PYC1", "ENSXETG00000033315", "Q5XGF7", "ENSXETT00000025854", "A8WGW3", "ENSXETT00000002941", "F6Z4N6", "ENSXETT00000035399" ] }, "reaction_10329909": { "compartment": "compartment_70101", "id": "reaction_10329909", "reactome": "R-XTR-5622134", "name": "CRABP1 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329651", "species_5334816" ], "products": [ "species_10329653" ], "modifiers": [], "additional_components": [ "ENSXETG00000040354", "species_215573", "A0A6I8QHI5", "ENSXETG00000040354" ] }, "reaction_10329655": { "compartment": "compartment_70101", "id": "reaction_10329655", "reactome": "R-XTR-5362525", "name": "CYP26A1,B1,C1 4-hydroxylate atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_10329653", "species_29364" ], "products": [ "species_10329651", "species_29356", "species_5362521", "species_29366" ], "modifiers": [ [ "species_10316440", "catalyst" ] ], "additional_components": [ "species_215573", "A0A6I8QHI5", "ENSXETG00000040354", "ENSXETG00000040354", "ENSXETG00000021546" ] }, "reaction_10332441": { "compartment": "compartment_876", "id": "reaction_10332441", "reactome": "R-XTR-6794346", "name": "NRXNs bind NLGNs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10332437", "species_10332431" ], "products": [ "species_10332439" ], "modifiers": [], "additional_components": [ "A0A6I8S9J2", "ENSXETG00000035941", "ENSXETG00000011090", "A0A6I8Q952", "ENSXETG00000011090", "A0A6I8S9J2", "ENSXETG00000035941" ] }, "reaction_10332482": { "compartment": "compartment_876", "id": "reaction_10332482", "reactome": "R-XTR-6797974", "name": "LRRTMs bind NRXNs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10332478", "species_10332431" ], "products": [ "species_10332480" ], "modifiers": [], "additional_components": [ "ENSXETG00000011090", "A0A6I8Q952", "ENSXETG00000011090" ] }, "reaction_10313806": { "compartment": "compartment_17963", "id": "reaction_10313806", "reactome": "R-XTR-177107", "name": "Secretion and activation of the latent large complex of TGF-beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313438" ], "products": [ "species_10313444" ], "modifiers": [], "additional_components": [ "F6SX40", "ENSXETT00000046545", "F6SX40", "ENSXETT00000046545" ] }, "reaction_10313440": { "compartment": "compartment_20699", "id": "reaction_10313440", "reactome": "R-XTR-170844", "name": "Latent TGF-beta-1 is cleaved by furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313434" ], "products": [ "species_10313438" ], "modifiers": [ [ "species_10313057", "catalyst" ] ], "additional_components": [ "F6SX40", "ENSXETT00000046545", "F6SX40", "ENSXETT00000046545", "ENSXETG00000015462" ] }, "reaction_10334815": { "compartment": "compartment_984", "id": "reaction_10334815", "reactome": "R-XTR-8849857", "name": "KLK5 cleaves and activates CELA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10334808" ], "products": [ "species_10334810", "species_10334812" ], "modifiers": [ [ "species_10334804", "catalyst" ] ], "additional_components": [ "ENSXETT00000031018", "ENSXETT00000031018", "ENSXETT00000031018", "ENSXETT00000037000" ] }, "reaction_10334837": { "compartment": "compartment_984", "id": "reaction_10334837", "reactome": "R-XTR-8850831", "name": "KLK5 cleaves and activates KLK8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10334831" ], "products": [ "species_10334835", "species_10334833" ], "modifiers": [ [ "species_10334804", "catalyst" ] ], "additional_components": [ "ENSXETT00000037000", "ENSXETT00000037000", "ENSXETT00000037000", "ENSXETT00000037000" ] }, "reaction_10332400": { "compartment": "compartment_984", "id": "reaction_10332400", "reactome": "R-XTR-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174675", "species_6789319" ], "modifiers": [ [ "species_10332391", "catalyst" ] ], "additional_components": [ "ENSXETT00000020371" ] }, "reaction_10312850": { "compartment": "compartment_876", "id": "reaction_10312850", "reactome": "R-XTR-140761", "name": "sequestered tissue factor -> tissue factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312848" ], "products": [ "species_10312846" ], "modifiers": [], "additional_components": [ "ENSXETG00000030465", "ENSXETG00000030465" ] }, "reaction_10322381": { "compartment": "compartment_984", "id": "reaction_10322381", "reactome": "R-XTR-1297333", "name": "Association of Acrosin Heavy and Light Chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322369", "species_10322377" ], "products": [ "species_10322379" ], "modifiers": [], "additional_components": [ "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8R444", "ENSXETG00000036832", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8R444", "ENSXETG00000036832", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8R444", "ENSXETG00000036832" ] }, "reaction_10322392": { "compartment": "compartment_984", "id": "reaction_10322392", "reactome": "R-XTR-1297354", "name": "Acrosin Cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322389" ], "products": [ "species_10322369", "species_10322377" ], "modifiers": [ [ "species_10322389", "catalyst" ] ], "additional_components": [ "A0A6I8R444", "ENSXETG00000036832", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8R444", "ENSXETG00000036832", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8R444", "ENSXETG00000036832", "A0A6I8R444", "ENSXETG00000036832", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8SN95", "ENSXETG00000034074" ] }, "reaction_10328392": { "compartment": "compartment_70101", "id": "reaction_10328392", "reactome": "R-XTR-3965450", "name": "DAAM1 recruits PFN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315909", "species_10328315" ], "products": [ "species_10328390" ], "modifiers": [], "additional_components": [ "ENSXETG00000036913", "A0A6I8SJ25", "ENSXETG00000017030", "Q05AS8", "ENSXETG00000017212", "A0A6I8SJ25", "ENSXETG00000017030", "Q05AS8", "ENSXETG00000017212", "A0A6I8RDQ2", "ENSXETG00000036913" ] }, "reaction_10328309": { "compartment": "compartment_876", "id": "reaction_10328309", "reactome": "R-XTR-3858482", "name": "DVL is recruited to the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328305", "species_10328303" ], "products": [ "species_10328307" ], "modifiers": [], "additional_components": [ "Q05AS8", "ENSXETG00000017212", "B2GUT4", "ENSXETT00000042046", "Q5BL72", "ENSXETT00000027115", "B2GUT4", "ENSXETT00000042046", "Q5BL72", "ENSXETT00000027115", "Q05AS8", "ENSXETG00000017212" ] }, "reaction_10328295": { "compartment": "compartment_70101", "id": "reaction_10328295", "reactome": "R-XTR-3858475", "name": "ppDVL recruits RAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328291", "species_10318239" ], "products": [ "species_10328293" ], "modifiers": [], "additional_components": [ "Q05AS8", "ENSXETG00000017212", "F7DEH8", "ENSXETT00000009928", "Q6GL60", "ENSXETT00000092508", "species_29438", "F7DEH8", "ENSXETT00000009928", "Q6GL60", "ENSXETT00000092508", "species_29438", "Q05AS8", "ENSXETG00000017212" ] }, "reaction_10316717": { "compartment": "compartment_70101", "id": "reaction_10316717", "reactome": "R-XTR-351863", "name": "Translocation of active caspase-8 to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316682" ], "products": [ "species_10316715" ], "modifiers": [], "additional_components": [ "A0A6I8Q0P2", "ENSXETG00000032748", "A0A6I8Q0P2", "ENSXETG00000032748" ] }, "reaction_10335361": { "compartment": "compartment_7660", "id": "reaction_10335361", "reactome": "R-XTR-8857692", "name": "RNA demethylases demethylate N6-methyladenosine RNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8857725", "species_113671", "species_111793" ], "products": [ "species_8857850", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10335358", "catalyst" ] ], "additional_components": [ "species_435347", "F6U6S7", "ENSXETT00000012796", "Q66JG8", "ENSXETT00000012702" ] }, "reaction_10337796": { "compartment": "compartment_7660", "id": "reaction_10337796", "reactome": "R-XTR-9624120", "name": "CEBPA binds CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311327", "species_10337788" ], "products": [ "species_10337794" ], "modifiers": [], "additional_components": [ "ENSXETT00000046130", "ENSXETG00000039574", "A0A6I8R9D5", "ENSXETG00000039574", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10337792": { "compartment": "compartment_7660", "id": "reaction_10337792", "reactome": "R-XTR-9624112", "name": "CEBPA binds CDK4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337784", "species_10337788" ], "products": [ "species_10337790" ], "modifiers": [], "additional_components": [ "ENSXETG00000035239", "ENSXETG00000039574", "A0A6I8R9D5", "ENSXETG00000039574", "A0A6I8R6Z7", "ENSXETG00000035239" ] }, "reaction_10334445": { "compartment": "compartment_70101", "id": "reaction_10334445", "reactome": "R-XTR-6806613", "name": "Keratin tetramers bind to form unit length filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334433" ], "products": [ "species_10334437" ], "modifiers": [], "additional_components": [ "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390" ] }, "reaction_10334431": { "compartment": "compartment_70101", "id": "reaction_10334431", "reactome": "R-XTR-6805546", "name": "Keratin type I binds keratin type II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334213", "species_10334427" ], "products": [ "species_10334429" ], "modifiers": [], "additional_components": [ "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390" ] }, "reaction_10334443": { "compartment": "compartment_70101", "id": "reaction_10334443", "reactome": "R-XTR-6806610", "name": "Keratin filament formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334439" ], "products": [ "species_10334441" ], "modifiers": [], "additional_components": [ "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390" ] }, "reaction_10334449": { "compartment": "compartment_70101", "id": "reaction_10334449", "reactome": "R-XTR-6806629", "name": "Formation of tonofilament bundles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334441" ], "products": [ "species_10334447" ], "modifiers": [], "additional_components": [ "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390" ] }, "reaction_10334435": { "compartment": "compartment_70101", "id": "reaction_10334435", "reactome": "R-XTR-6805573", "name": "Keratin type I/type II heterodimers form tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334429" ], "products": [ "species_10334433" ], "modifiers": [], "additional_components": [ "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390" ] }, "reaction_10331235": { "compartment": "compartment_876", "id": "reaction_10331235", "reactome": "R-XTR-5692408", "name": "NPR2 binds NPPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331227", "species_10331231" ], "products": [ "species_10331233" ], "modifiers": [], "additional_components": [ "ENSXETG00000041083", "ENSXETG00000031971", "A0A6I8SDR4", "ENSXETG00000031971", "A0A6I8SMD0", "ENSXETG00000041083" ] }, "reaction_10329753": { "compartment": "compartment_70101", "id": "reaction_10329753", "reactome": "R-XTR-5578777", "name": "DMPK phosphorylates PLN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10318047" ], "products": [ "species_29370", "species_10318052" ], "modifiers": [ [ "species_10329750", "catalyst" ] ], "additional_components": [ "A0A6I8ST89", "ENSXETG00000036412", "A0A6I8ST89", "ENSXETG00000036412", "F6V346", "ENSXETT00000036273" ] }, "reaction_10329776": { "compartment": "compartment_70101", "id": "reaction_10329776", "reactome": "R-XTR-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10329773", "catalyst" ] ], "additional_components": [ "F6WH56", "ENSXETT00000048965", "F7AEN8", "ENSXETT00000009094" ] }, "reaction_10312747": { "compartment": "compartment_70101", "id": "reaction_10312747", "reactome": "R-XTR-114553", "name": "Activation of conventional Protein Kinase C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_10312735", "species_74016" ], "products": [ "species_10312745" ], "modifiers": [ [ "species_114519", "catalyst" ] ], "additional_components": [ "ENSXETG00000017294", "species_114519", "species_33625", "species_74112", "A8KBH6", "ENSXETG00000017294" ] }, "reaction_10318808": { "compartment": "compartment_876", "id": "reaction_10318808", "reactome": "R-XTR-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318758" ], "products": [ "species_10318806" ], "modifiers": [], "additional_components": [ "A0A6I8QDT0", "ENSXETG00000039678", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8S6I0", "ENSXETG00000027692", "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942", "A0A6I8QL92", "ENSXETG00000039008", "F6SYS3", "ENSXETT00000046350", "A0A6I8S033", "ENSXETG00000009423", "A0A6I8PY35", "ENSXETG00000033269", "F7B6V1", "ENSXETT00000038623", "A0A6I8Q251", "ENSXETG00000030791", "F7D5C5", "ENSXETT00000001620", "F6TMK5", "ENSXETT00000046700", "F7CZB7", "ENSXETT00000006287", "A0A6I8PVG7", "ENSXETG00000031284", "A0A6I8Q0D7", "ENSXETG00000032630", "F7C1U1", "ENSXETT00000043296", "Q5BKJ7", "ENSXETT00000050639", "A0A6I8SC83", "ENSXETG00000038196", "F6SX40", "ENSXETT00000046545", "A0A6I8STH4", "ENSXETG00000035410", "F6YIE1", "ENSXETT00000016028", "Q6P326", "ENSXETG00000021646", "Q66JG0", "ENSXETG00000008500", "F7CWY4", "ENSXETT00000011877", "F7CZB7", "ENSXETT00000006287", "A0A6I8S6I0", "ENSXETG00000027692", "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942", "Q66JG0", "ENSXETG00000008500", "Q5BKJ7", "ENSXETT00000050639", "F7B6V1", "ENSXETT00000038623", "A0A6I8PY35", "ENSXETG00000033269", "A0A6I8QDT0", "ENSXETG00000039678", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8S033", "ENSXETG00000009423", "F7D5C5", "ENSXETT00000001620", "A0A6I8STH4", "ENSXETG00000035410", "A0A6I8Q0D7", "ENSXETG00000032630", "F6SYS3", "ENSXETT00000046350", "A0A6I8QL92", "ENSXETG00000039008", "F7CWY4", "ENSXETT00000011877", "F6YIE1", "ENSXETT00000016028", "Q6P326", "ENSXETG00000021646", "F6TMK5", "ENSXETT00000046700", "F7C1U1", "ENSXETT00000043296", "A0A6I8SC83", "ENSXETG00000038196", "A0A6I8Q251", "ENSXETG00000030791", "A0A6I8PVG7", "ENSXETG00000031284", "F6SX40", "ENSXETT00000046545" ] }, "reaction_10318868": { "compartment": "compartment_876", "id": "reaction_10318868", "reactome": "R-XTR-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318842" ], "products": [ "species_10318866" ], "modifiers": [], "additional_components": [ "species_29438", "species_29370", "B0BLS9", "ENSXETT00000049183", "species_109496", "Q28F45", "ENSXETT00000055303", "species_113593", "Q28HY7", "ENSXETG00000000595", "species_29372", "A0A6I8RL39", "ENSXETG00000006887", "A0A6I8SSC0", "ENSXETG00000036712", "species_74112", "species_114523", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350", "A0A6I8QL92", "ENSXETG00000039008", "species_29420", "species_159450", "species_74112", "species_29438", "species_29370", "species_159450", "species_109496", "species_113593", "A0A6I8RL39", "ENSXETG00000006887", "A0A6I8SSC0", "ENSXETG00000036712", "B0BLS9", "ENSXETT00000049183", "Q28HY7", "ENSXETG00000000595", "species_114523", "Q28F45", "ENSXETT00000055303", "species_29372", "species_29420", "A0A6I8QL92", "ENSXETG00000039008", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350" ] }, "reaction_10318948": { "compartment": "compartment_70101", "id": "reaction_10318948", "reactome": "R-XTR-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318936" ], "products": [ "species_10318946" ], "modifiers": [], "additional_components": [ "Q6DIF4", "ENSXETG00000000629", "Q28IX8", "ENSXETG00000019288", "A0A6I8RS05", "ENSXETG00000036422", "Q0IIW3", "ENSXETT00000015994", "Q6DIF4", "ENSXETG00000000629", "Q0IIW3", "ENSXETT00000015994", "Q28IX8", "ENSXETG00000019288", "A0A6I8RS05", "ENSXETG00000036422" ] }, "reaction_10318918": { "compartment": "compartment_984", "id": "reaction_10318918", "reactome": "R-XTR-482770", "name": "Release of platelet secretory granule components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318910" ], "products": [ "species_10318916" ], "modifiers": [], "additional_components": [ "F7E728", "ENSXETG00000020755", "A0A6I8PU04", "ENSXETG00000033423", "Q501K5", "ENSXETG00000011814", "A0A6I8PU04", "ENSXETG00000033423", "Q501K5", "ENSXETG00000011814", "F7E728", "ENSXETG00000020755" ] }, "reaction_10316707": { "compartment": "compartment_161320", "id": "reaction_10316707", "reactome": "R-XTR-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316703" ], "products": [ "species_10316705" ], "modifiers": [], "additional_components": [ "ENSXETT00000041328", "ENSXETT00000041328" ] }, "reaction_10318882": { "compartment": "compartment_876", "id": "reaction_10318882", "reactome": "R-XTR-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318876" ], "products": [ "species_10318880" ], "modifiers": [], "additional_components": [ "A0A6I8SL99", "ENSXETG00000003366", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8SL99", "ENSXETG00000003366", "A0A6I8SFE9", "ENSXETG00000039556" ] }, "reaction_10318898": { "compartment": "compartment_876", "id": "reaction_10318898", "reactome": "R-XTR-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318892" ], "products": [ "species_10318896" ], "modifiers": [], "additional_components": [ "A0A6I8Q083", "ENSXETG00000031004", "A0A6I8S279", "ENSXETG00000037724", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8Q083", "ENSXETG00000031004", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8S279", "ENSXETG00000037724" ] }, "reaction_10318249": { "compartment": "compartment_70101", "id": "reaction_10318249", "reactome": "R-XTR-442273", "name": "VAV1 is a GEF for Rho/Rac family GTPases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10318237" ], "products": [ "species_29420", "species_10318239" ], "modifiers": [ [ "species_10318242", "catalyst" ], [ "species_10318247", "catalyst" ], [ "species_10318245", "inhibitor" ] ], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "Q6GL60", "ENSXETT00000092508", "species_29420", "F7DEH8", "ENSXETT00000009928", "Q6GL60", "ENSXETT00000092508", "species_29438", "ENSXETT00000043225", "species_179838", "L7N3Q8", "ENSXETT00000043225", "species_179856", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10318123": { "compartment": "compartment_876", "id": "reaction_10318123", "reactome": "R-XTR-429497", "name": "SLP-76 stimulates PLC gamma 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318121" ], "products": [ "species_10312756" ], "modifiers": [], "additional_components": [ "ENSXETG00000003578", "ENSXETG00000003578" ] }, "reaction_10312759": { "compartment": "compartment_70101", "id": "reaction_10312759", "reactome": "R-XTR-114689", "name": "PLC gamma 2-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10312756", "catalyst" ] ], "additional_components": [ "ENSXETG00000003578" ] }, "reaction_10322394": { "compartment": "compartment_876", "id": "reaction_10322394", "reactome": "R-XTR-1297444", "name": "Binding of cAMP to HCN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322341", "species_30389" ], "products": [ "species_10322343" ], "modifiers": [], "additional_components": [ "A0A6I8SMA9", "ENSXETG00000017714", "A0A6I8RXX5", "ENSXETG00000031566", "species_30389", "A0A6I8SMA9", "ENSXETG00000017714", "A0A6I8RXX5", "ENSXETG00000031566" ] }, "reaction_10322346": { "compartment": "compartment_876", "id": "reaction_10322346", "reactome": "R-XTR-1296043", "name": "Activation of HCN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10322343", "catalyst" ] ], "additional_components": [ "species_30389", "A0A6I8SMA9", "ENSXETG00000017714", "A0A6I8RXX5", "ENSXETG00000031566" ] }, "reaction_10317036": { "compartment": "compartment_204883", "id": "reaction_10317036", "reactome": "R-XTR-375342", "name": "Connexin 36 mediated neuronal gap junction communication", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_29804" ], "modifiers": [ [ "species_10317033", "catalyst" ] ], "additional_components": [ "A0A6I8RRX1", "ENSXETG00000038711" ] }, "reaction_10311663": { "compartment": "compartment_876", "id": "reaction_10311663", "reactome": "R-XTR-71050", "name": "Trimerization of the FASL:FAS receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311659" ], "products": [ "species_10311661" ], "modifiers": [], "additional_components": [ "A0A6I8PTW1", "ENSXETG00000031916", "A0A6I8QWZ8", "ENSXETG00000041356", "A0A6I8PTW1", "ENSXETG00000031916", "A0A6I8QWZ8", "ENSXETG00000041356" ] }, "reaction_10312086": { "compartment": "compartment_876", "id": "reaction_10312086", "reactome": "R-XTR-75244", "name": "FASL binds FAS Receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311653", "species_10311657" ], "products": [ "species_10311659" ], "modifiers": [], "additional_components": [ "ENSXETG00000041356", "ENSXETG00000031916", "A0A6I8PTW1", "ENSXETG00000031916", "A0A6I8QWZ8", "ENSXETG00000041356" ] }, "reaction_10312879": { "compartment": "compartment_984", "id": "reaction_10312879", "reactome": "R-XTR-140847", "name": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312839", "species_74112" ], "products": [ "species_10312833", "species_10312877" ], "modifiers": [], "additional_components": [ "F6YIE1", "ENSXETT00000016028", "A0A6I8PQF3", "ENSXETG00000031728", "ENSXETG00000031728", "species_74112", "F6YIE1", "ENSXETT00000016028" ] }, "reaction_10326879": { "compartment": "compartment_876", "id": "reaction_10326879", "reactome": "R-XTR-2534378", "name": "Hv1 Mediated H+ Permeability", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1132304" ], "products": [ "species_351626" ], "modifiers": [ [ "species_10326876", "catalyst" ] ], "additional_components": [ "Q5M8L8", "ENSXETT00000045238" ] }, "reaction_10326870": { "compartment": "compartment_876", "id": "reaction_10326870", "reactome": "R-XTR-2534346", "name": "SPAM1 Binds Hyaluronic Acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326866", "species_1297302" ], "products": [ "species_10326868" ], "modifiers": [], "additional_components": [ "ENSXETG00000033261", "species_1297302", "A0A6I8PVK0", "ENSXETG00000033261" ] }, "reaction_10330885": { "compartment": "compartment_5460", "id": "reaction_10330885", "reactome": "R-XTR-5688289", "name": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_10330874" ], "products": [ "species_5688337", "species_5688274", "species_10330876" ], "modifiers": [ [ "species_10330882", "catalyst" ] ], "additional_components": [ "F6WI63", "ENSXETT00000017597", "Q5XGI4", "ENSXETT00000103326", "F6WI63", "ENSXETT00000017597", "Q5XGI4", "ENSXETT00000103326", "A0A6I8PP16", "ENSXETG00000032567", "species_29426" ] }, "reaction_10330902": { "compartment": "compartment_17927", "id": "reaction_10330902", "reactome": "R-XTR-5688294", "name": "SIRT5 deacetylates Cytochrome C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5688282", "species_10330893" ], "products": [ "species_5688281", "species_10312698", "species_5688340" ], "modifiers": [ [ "species_10330899", "catalyst" ] ], "additional_components": [ "Q640U4", "ENSXETT00000018532", "Q6PBF4", "ENSXETT00000049267", "Q6PBF4", "ENSXETT00000049267", "Q640U4", "ENSXETT00000018532", "species_29426", "F7DKV7", "ENSXETT00000004834" ] }, "reaction_10335711": { "compartment": "compartment_70101", "id": "reaction_10335711", "reactome": "R-XTR-8865107", "name": "MICAL1 produces NADP+, H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_29366", "species_29408" ], "modifiers": [ [ "species_10335708", "catalyst" ] ], "additional_components": [ "A0A6I8PP59", "ENSXETG00000013342", "species_113596" ] }, "reaction_10321770": { "compartment": "compartment_7660", "id": "reaction_10321770", "reactome": "R-XTR-997263", "name": "JMJD1C demethylates H3K9 mono- and di-methylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321761" ], "products": [ "species_10321763" ], "modifiers": [ [ "species_10321767", "catalyst" ] ], "additional_components": [ "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "ENSXETG00000007684" ] }, "reaction_10321786": { "compartment": "compartment_7660", "id": "reaction_10321786", "reactome": "R-XTR-1008200", "name": "NFE2 binds the beta globin locus control region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1008228", "species_10321782" ], "products": [ "species_10321784" ], "modifiers": [], "additional_components": [ "F7A9R6", "ENSXETT00000041786", "A0A6I8PVX4", "ENSXETG00000027400", "F7A9R6", "ENSXETT00000041786", "A0A6I8PVX4", "ENSXETG00000027400" ] }, "reaction_10321794": { "compartment": "compartment_70101", "id": "reaction_10321794", "reactome": "R-XTR-1011598", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317328", "species_10321790" ], "products": [ "species_10321792" ], "modifiers": [], "additional_components": [ "ENSXETT00000092508", "ENSXETG00000003669", "A0A6I8SJK6", "ENSXETG00000003669", "Q6GL60", "ENSXETT00000092508" ] } }, "collapsed_reaction_dictionary": { "reaction_10315596": { "compartment": "compartment_876", "id": "reaction_10315596", "reactome": "R-XTR-199576", "name": "KIR3DL2 interacting with HLA-A3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315590", "species_10315592" ], "products": [ "species_10315594" ], "modifiers": [], "additional_components": [ "ENSXETG00000032630", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8Q0D7", "ENSXETG00000032630" ] }, "reaction_10331487": { "compartment": "compartment_876", "id": "reaction_10331487", "reactome": "R-XTR-5696358", "name": "TREM,CD300 binds lipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696348", "species_10331483" ], "products": [ "species_10331485" ], "modifiers": [], "additional_components": [ "species_8959486", "species_33625", "species_8959490", "A0A6I8PSB6", "ENSXETG00000032041", "A0A6I8QSY3", "ENSXETG00000037809", "A0A6I8SNS8", "ENSXETG00000036363", "A0A6I8PSB6", "ENSXETG00000032041", "A0A6I8QSY3", "ENSXETG00000037809", "A0A6I8SNS8", "ENSXETG00000036363", "species_8959486", "species_33625", "species_8959490" ] }, "reaction_10315604": { "compartment": "compartment_876", "id": "reaction_10315604", "reactome": "R-XTR-199579", "name": "KIR2DL4 interacting with HLA-G", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315600", "species_10315598" ], "products": [ "species_10315602" ], "modifiers": [], "additional_components": [ "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8PKK9", "ENSXETG00000033246", "ENSXETG00000032630", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8PKK9", "ENSXETG00000033246" ] }, "reaction_10330788": { "compartment": "compartment_876", "id": "reaction_10330788", "reactome": "R-XTR-5685607", "name": "Sialic acid binds SIGLEC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330784", "species_1006168" ], "products": [ "species_10330786" ], "modifiers": [], "additional_components": [ "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8R800", "ENSXETG00000040970", "species_1006168", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8R800", "ENSXETG00000040970" ] }, "reaction_10314694": { "compartment": "compartment_876", "id": "reaction_10314694", "reactome": "R-XTR-199154", "name": "CD200 binds to CD200R", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314690", "species_10314686" ], "products": [ "species_10314692" ], "modifiers": [], "additional_components": [ "ENSXETG00000034946", "ENSXETG00000039727", "A0A6I8QKB5", "ENSXETG00000039727", "A0A6I8SWZ3", "ENSXETG00000034946" ] }, "reaction_10315536": { "compartment": "compartment_876", "id": "reaction_10315536", "reactome": "R-XTR-199161", "name": "Fc gamma receptors interact with antigen-bound IgG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315514", "species_10315532" ], "products": [ "species_10315534" ], "modifiers": [], "additional_components": [ "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8PWK1", "ENSXETT00000069302", "A0A6I8PXL5", "ENSXETT00000069302", "A0A5G3K4A2", "ENSXETT00000069302", "F7ATU6", "ENSXETT00000069302", "A0A6I8PNW8", "ENSXETT00000069302", "L7N2W1", "ENSXETT00000013311", "A0A6I8SSF0", "ENSXETT00000069302", "A0A6I8SYX6", "ENSXETT00000069302", "A0A6I8SF25", "ENSXETT00000069302", "A0A6I8SJ82", "ENSXETT00000069302", "A0A6I8SCS2", "ENSXETT00000069302", "A0A6I8SCZ9", "ENSXETT00000069302", "A0A6I8S4K2", "ENSXETT00000069302", "A0A6I8S824", "ENSXETT00000069302", "A0A6I8S1H6", "ENSXETT00000069302", "A0A6I8S3H5", "ENSXETT00000069302", "A0A6I8RTG9", "ENSXETT00000069302", "A0A6I8RYE0", "ENSXETT00000069302", "A0A6I8RLS5", "ENSXETT00000069302", "A0A6I8RQ73", "ENSXETT00000069302", "A0A6I8RDF6", "ENSXETT00000069302", 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"ENSXETG00000040383", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212", "A0A6I8SK71", "ENSXETG00000040212", "A0A6I8QZL1", "ENSXETG00000040212", "A0A6I8RUJ4", "ENSXETG00000040212", "A0A6I8QKP4", "ENSXETG00000040212", "A0A6I8RNX1", "ENSXETG00000040212", "A0A6I8SYV6", "ENSXETG00000040212" ] }, "reaction_10315570": { "compartment": "compartment_876", "id": "reaction_10315570", "reactome": "R-XTR-199404", "name": "CD40L binds CD40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315562", "species_10315566" ], "products": [ "species_10315568" ], "modifiers": [], "additional_components": [ "F6WJ69", "ENSXETT00000005335", "A0A6I8PXA6", "ENSXETG00000030595", "F6WJ69", "ENSXETT00000005335", "A0A6I8PXA6", "ENSXETG00000030595" ] }, "reaction_10313549": { "compartment": "compartment_70101", "id": "reaction_10313549", "reactome": "R-XTR-175983", "name": "COMT transfer CH3 from AdoMet to 3,4DHBNZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_175977", "species_71284" ], "products": [ "species_175978", "species_71285" ], "modifiers": [ [ "species_10313546", "catalyst" ] ], "additional_components": [ "ENSXETT00000064849" ] }, "reaction_10313556": { "compartment": "compartment_70101", "id": "reaction_10313556", "reactome": "R-XTR-175987", "name": "NNMT transfers CH3 from AdoMet to PY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_175973", "species_71284" ], "products": [ "species_175979", "species_71285" ], "modifiers": [ [ "species_10313553", "catalyst" ] ], "additional_components": [ "ENSXETG00000028049" ] }, "reaction_10329809": { "compartment": "compartment_70101", "id": "reaction_10329809", "reactome": "R-XTR-5603114", "name": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_174390" ], "products": [ "species_111294", "species_29372", "species_71284" ], "modifiers": [ [ "species_10329806", "catalyst" ] ], "additional_components": [ "species_109496", "F6X2C1", "ENSXETT00000002716", "species_74126", "Q566L8", "ENSXETG00000015071" ] }, "reaction_10312209": { "compartment": "compartment_17960", "id": "reaction_10312209", "reactome": "R-XTR-76386", "name": "CYP1A2 S-demethylates 6MMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_76384", "species_113601" ], "products": [ "species_143501", "species_113519", "species_113564", "species_33153" ], "modifiers": [ [ "species_10312204", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10331414": { "compartment": "compartment_5460", "id": "reaction_10331414", "reactome": "R-XTR-5694563", "name": "ABHD10 hydrolyses MPAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694574", "species_113521" ], "products": [ "species_5694569", "species_5694565" ], "modifiers": [ [ "species_10331411", "catalyst" ] ], "additional_components": [ "ENSXETT00000020196" ] }, "reaction_10313610": { "compartment": "compartment_17957", "id": "reaction_10313610", "reactome": "R-XTR-176059", "name": "GST trimers transfer GS from GSH to luminal substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158543", "species_176065" ], "products": [ "species_176048" ], "modifiers": [ [ "species_10313607", "catalyst" ] ], "additional_components": [ "species_156523", "species_38987", "species_76396", "CHEBI:32639", "CHEBI:2505", "CHEBI:35896", "A0A6I8RJ83", "ENSXETG00000036671", "F6PX96", "ENSXETT00000016673", "F6VC96", "ENSXETT00000010309" ] }, "reaction_10331194": { "compartment": "compartment_70101", "id": "reaction_10331194", "reactome": "R-XTR-5692232", "name": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_5692212" ], "products": [ "species_5692216", "species_29364" ], "modifiers": [ [ "species_10330359", "catalyst" ] ], "additional_components": [ "ENSXETT00000007570" ] }, "reaction_10322294": { "compartment": "compartment_70101", "id": "reaction_10322294", "reactome": "R-XTR-1247922", "name": "GGCT transforms gGluCys to OPRO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393" ], "products": [ "species_111707", "species_1247942" ], "modifiers": [ [ "species_10322291", "catalyst" ] ], "additional_components": [ "F6PKI1", "ENSXETT00000047646" ] }, "reaction_10313587": { "compartment": "compartment_70101", "id": "reaction_10313587", "reactome": "R-XTR-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10313584", "catalyst" ] ], "additional_components": [ "species_76396", "CHEBI:34718", "CHEBI:30614", "CHEBI:8927", "CHEBI:32639", "CHEBI:34479", "A0A6I8S817", "ENSXETG00000036388", "F6SJ37", "ENSXETT00000045440", "A0A6I8QYI0", "ENSXETG00000038870" ] }, "reaction_10331421": { "compartment": "compartment_70101", "id": "reaction_10331421", "reactome": "R-XTR-5695964", "name": "ABHD14B hydrolyses PNPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5695960", "species_29356" ], "products": [ "species_5695950", "species_76179" ], "modifiers": [ [ "species_10331418", "catalyst" ] ], "additional_components": [ "ENSXETT00000063063" ] }, "reaction_10336924": { "compartment": "compartment_17963", "id": "reaction_10336924", "reactome": "R-XTR-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8851226", "species_8953493" ], "modifiers": [ [ "species_10336921", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "species_109496", "Q28CL4", "ENSXETT00000012482" ] }, "reaction_10313663": { "compartment": "compartment_70101", "id": "reaction_10313663", "reactome": "R-XTR-176631", "name": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176626" ], "products": [ "species_176496", "species_158466" ], "modifiers": [ [ "species_10313660", "catalyst" ] ], "additional_components": [ "A0A6I8PTM1", "ENSXETG00000033931", "B0BM84", "ENSXETT00000064929" ] }, "reaction_10313656": { "compartment": "compartment_70101", "id": "reaction_10313656", "reactome": "R-XTR-176604", "name": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176565", "species_158471" ], "products": [ "species_176483", "species_158466" ], "modifiers": [ [ "species_10313634", "catalyst" ] ], "additional_components": [ "B0BM84", "ENSXETT00000064929", "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313658": { "compartment": "compartment_70101", "id": "reaction_10313658", "reactome": "R-XTR-176609", "name": "cholesterol + PAPS => cholesterol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_158471" ], "products": [ "species_176618", "species_158466" ], "modifiers": [ [ "species_10313643", "catalyst" ] ], "additional_components": [ "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313654": { "compartment": "compartment_70101", "id": "reaction_10313654", "reactome": "R-XTR-176588", "name": "lithocholate + PAPS => lithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_158471" ], "products": [ "species_176555", "species_158466" ], "modifiers": [ [ "species_10313634", "catalyst" ] ], "additional_components": [ "B0BM84", "ENSXETT00000064929", "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313649": { "compartment": "compartment_70101", "id": "reaction_10313649", "reactome": "R-XTR-176517", "name": "SULTs transfer (SO4)2- group to PREG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_158471" ], "products": [ "species_176665", "species_158466" ], "modifiers": [ [ "species_10313643", "catalyst" ] ], "additional_components": [ "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313651": { "compartment": "compartment_70101", "id": "reaction_10313651", "reactome": "R-XTR-176585", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176667", "species_158471" ], "products": [ "species_176564", "species_158466" ], "modifiers": [ [ "species_10313636", "catalyst" ] ], "additional_components": [ "F6QKH7", "ENSXETT00000042862", "L7N312", "ENSXETT00000017267", "B0BM84", "ENSXETT00000064929", "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313682": { "compartment": "compartment_70101", "id": "reaction_10313682", "reactome": "R-XTR-176669", "name": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176566" ], "products": [ "species_176500", "species_158466" ], "modifiers": [ [ "species_10313679", "catalyst" ] ], "additional_components": [ "F6QKH7", "ENSXETT00000042862", "L7N312", "ENSXETT00000017267" ] }, "reaction_10313677": { "compartment": "compartment_70101", "id": "reaction_10313677", "reactome": "R-XTR-176664", "name": "estrone + PAPS => estrone 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176575", "species_158471" ], "products": [ "species_176501", "species_158466" ], "modifiers": [ [ "species_10313634", "catalyst" ] ], "additional_components": [ "B0BM84", "ENSXETT00000064929", "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313646": { "compartment": "compartment_70101", "id": "reaction_10313646", "reactome": "R-XTR-176494", "name": "SULTs transfer (SO4)2- group to 27HCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176617", "species_158471" ], "products": [ "species_176502", "species_158466" ], "modifiers": [ [ "species_10313643", "catalyst" ] ], "additional_components": [ "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10336939": { "compartment": "compartment_17963", "id": "reaction_10336939", "reactome": "R-XTR-8954262", "name": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336928", "species_741440" ], "products": [ "species_742343", "species_10336932" ], "modifiers": [ [ "species_10336936", "catalyst" ] ], "additional_components": [ "ENSXETG00000039537", "ENSXETG00000039537", "ENSXETG00000017664" ] }, "reaction_10313674": { "compartment": "compartment_70101", "id": "reaction_10313674", "reactome": "R-XTR-176646", "name": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5695950", "species_158471" ], "products": [ "species_176600", "species_158466" ], "modifiers": [ [ "species_10313671", "catalyst" ] ], "additional_components": [ "F6QKH7", "ENSXETT00000042862", "L7N312", "ENSXETT00000017267" ] }, "reaction_10313639": { "compartment": "compartment_70101", "id": "reaction_10313639", "reactome": "R-XTR-176474", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176486" ], "products": [ "species_176519", "species_158466" ], "modifiers": [ [ "species_10313636", "catalyst" ] ], "additional_components": [ "F6QKH7", "ENSXETT00000042862", "L7N312", "ENSXETT00000017267", "B0BM84", "ENSXETT00000064929", "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313039": { "compartment": "compartment_5460", "id": "reaction_10313039", "reactome": "R-XTR-159566", "name": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_159447" ], "products": [ "species_29374", "species_159564" ], "modifiers": [ [ "species_10313036", "catalyst" ] ], "additional_components": [ "A0A6I8RQD3", "ENSXETG00000038499" ] }, "reaction_10313024": { "compartment": "compartment_5460", "id": "reaction_10313024", "reactome": "R-XTR-159443", "name": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_159446" ], "products": [ "species_159448", "species_159450", "species_159447" ], "modifiers": [ [ "species_10313019", "catalyst" ] ], "additional_components": [ "ENSXETT00000036505" ] }, "reaction_10313808": { "compartment": "compartment_5460", "id": "reaction_10313808", "reactome": "R-XTR-177157", "name": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_177153" ], "products": [ "species_159448", "species_159450", "species_177137" ], "modifiers": [ [ "species_10313019", "catalyst" ] ], "additional_components": [ "ENSXETT00000036505" ] }, "reaction_10313045": { "compartment": "compartment_5460", "id": "reaction_10313045", "reactome": "R-XTR-159567", "name": "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_159559" ], "products": [ "species_159448", "species_159450", "species_159557" ], "modifiers": [ [ "species_10313019", "catalyst" ] ], "additional_components": [ "ENSXETT00000036505" ] }, "reaction_10313047": { "compartment": "compartment_5460", "id": "reaction_10313047", "reactome": "R-XTR-159574", "name": "salicylate-CoA + glycine => salicyluric acid + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_159557" ], "products": [ "species_29374", "species_159572" ], "modifiers": [ [ "species_10313036", "catalyst" ] ], "additional_components": [ "A0A6I8RQD3", "ENSXETG00000038499" ] }, "reaction_10332302": { "compartment": "compartment_70101", "id": "reaction_10332302", "reactome": "R-XTR-6786190", "name": "CMBL hydrolyses OM to OLMS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6786175" ], "products": [ "species_6786194", "species_6786179" ], "modifiers": [ [ "species_10332299", "catalyst" ] ], "additional_components": [ "ENSXETT00000054521" ] }, "reaction_10331432": { "compartment": "compartment_5460", "id": "reaction_10331432", "reactome": "R-XTR-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10311857", "catalyst" ] ], "additional_components": [ "A0A6I8RHR6", "ENSXETG00000020930" ] }, "reaction_10311851": { "compartment": "compartment_70101", "id": "reaction_10311851", "reactome": "R-XTR-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_29510", "species_73473" ], "modifiers": [ [ "species_10311848", "catalyst" ] ], "additional_components": [ "A0A6I8RYK1", "ENSXETG00000032351", "species_29426", "F7DZV1", "ENSXETT00000020485", "F6YU63", "ENSXETT00000024409", "A0A6I8PVR9", "ENSXETG00000032433" ] }, "reaction_10331211": { "compartment": "compartment_70101", "id": "reaction_10331211", "reactome": "R-XTR-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_5692249", "species_70106", "species_73473" ], "modifiers": [ [ "species_10331208", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8PVR9", "ENSXETG00000032433", "A0A6I8RYK1", "ENSXETG00000032351", "F6YU63", "ENSXETT00000024409", "F7DZV1", "ENSXETT00000020485" ] }, "reaction_10311860": { "compartment": "compartment_5460", "id": "reaction_10311860", "reactome": "R-XTR-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10311857", "catalyst" ] ], "additional_components": [ "A0A6I8RHR6", "ENSXETG00000020930" ] }, "reaction_10331448": { "compartment": "compartment_984", "id": "reaction_10331448", "reactome": "R-XTR-5696131", "name": "AOC1 deaminates Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_390899", "species_352327" ], "products": [ "species_351626", "species_2022135", "species_351629", "species_5696128" ], "modifiers": [ [ "species_10331445", "catalyst" ] ], "additional_components": [ "species_74112", "CHEBI:28694", "A0A6I8R549", "ENSXETG00000011988" ] }, "reaction_10316604": { "compartment": "compartment_17960", "id": "reaction_10316604", "reactome": "R-XTR-217258", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_217315" ], "products": [ "species_113519", "species_113564", "species_217320" ], "modifiers": [ [ "species_10316601", "catalyst" ] ], "additional_components": [ "species_109496", "species_113596", "A0A6I8RVH1", "ENSXETG00000009900", "A0A6I8R1H4", "ENSXETG00000025145" ] }, "reaction_10312825": { "compartment": "compartment_17957", "id": "reaction_10312825", "reactome": "R-XTR-139970", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30373", "species_113601" ], "products": [ "species_113519", "species_113564", "species_140963" ], "modifiers": [ [ "species_10312822", "catalyst" ] ], "additional_components": [ "species_113596", "A0A6I8Q243", "ENSXETG00000025142" ] }, "reaction_10316593": { "compartment": "compartment_17960", "id": "reaction_10316593", "reactome": "R-XTR-217255", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_159154" ], "products": [ "species_113519", "species_113564", "species_217269" ], "modifiers": [ [ "species_10316590", "catalyst" ] ], "additional_components": [ "A0A6I8RVH1", "ENSXETG00000009900", "A0A6I8R1H4", "ENSXETG00000025145", "species_113596" ] }, "reaction_10312236": { "compartment": "compartment_12045", "id": "reaction_10312236", "reactome": "R-XTR-76496", "name": "PTGIS, CYP8A1 isomerise PGH2 to PGI2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30138" ], "products": [ "species_31593" ], "modifiers": [ [ "species_10312233", "catalyst" ] ], "additional_components": [ "ENSXETG00000001780" ] }, "reaction_10316443": { "compartment": "compartment_12045", "id": "reaction_10316443", "reactome": "R-XTR-212007", "name": "CYP26A1,B1 4-hydroxylate atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_215573", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215584" ], "modifiers": [ [ "species_10316440", "catalyst" ] ], "additional_components": [ "ENSXETG00000021546" ] }, "reaction_10316086": { "compartment": "compartment_70101", "id": "reaction_10316086", "reactome": "R-XTR-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_8963870", "species_29364" ], "products": [ "species_8963879", "species_29356", "species_29366" ], "modifiers": [ [ "species_10316083", "catalyst" ] ], "additional_components": [ "ENSXETT00000021283" ] }, "reaction_10312222": { "compartment": "compartment_12045", "id": "reaction_10312222", "reactome": "R-XTR-76453", "name": "Coumarin is 7-hydroxylated by CYP2A6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_76328", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76452" ], "modifiers": [ [ "species_10312219", "catalyst" ] ], "additional_components": [ "A0A6I8T1P2", "ENSXETG00000027556" ] }, "reaction_10316377": { "compartment": "compartment_12045", "id": "reaction_10316377", "reactome": "R-XTR-211948", "name": "CYP3A4 can N-demethylate loperamide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_213155" ], "products": [ "species_113519", "species_113564", "species_213151" ], "modifiers": [ [ "species_10316374", "catalyst" ] ], "additional_components": [ "F7B981", "ENSXETT00000026362", "A0A6I8Q6H5", "ENSXETT00000026362" ] }, "reaction_10316372": { "compartment": "compartment_12045", "id": "reaction_10316372", "reactome": "R-XTR-211929", "name": "CYP2C19 5-hydroxylates omeprazole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211892", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211944" ], "modifiers": [ [ "species_10316367", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10316436": { "compartment": "compartment_12045", "id": "reaction_10316436", "reactome": "R-XTR-212005", "name": "CYP2F1 dehydrogenates 3-methylindole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_213162", "species_113601" ], "products": [ "species_113519", "species_113564", "species_213163" ], "modifiers": [ [ "species_10316433", "catalyst" ] ], "additional_components": [ "A0A6I8QHP5", "ENSXETG00000035878" ] }, "reaction_10316564": { "compartment": "compartment_12045", "id": "reaction_10316564", "reactome": "R-XTR-213175", "name": "CYP3A4,5 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_156522", "species_113601" ], "products": [ "species_113519", "species_113564", "species_156523" ], "modifiers": [ [ "species_10316561", "catalyst" ] ], "additional_components": [ "A0A6I8Q6H5", "ENSXETT00000026362", "F7B981", "ENSXETT00000026362" ] }, "reaction_10316370": { "compartment": "compartment_12045", "id": "reaction_10316370", "reactome": "R-XTR-211910", "name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211906", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211894" ], "modifiers": [ [ "species_10316367", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10316365": { "compartment": "compartment_12045", "id": "reaction_10316365", "reactome": "R-XTR-211882", "name": "CYP3A7 can 6beta-hydroxylate testosterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30321", "species_113601" ], "products": [ "species_113519", "species_113564", "species_213144" ], "modifiers": [ [ "species_10316362", "catalyst" ] ], "additional_components": [ "A0A6I8Q6H5", "ENSXETT00000026362", "F7B981", "ENSXETT00000026362" ] }, "reaction_10316431": { "compartment": "compartment_12045", "id": "reaction_10316431", "reactome": "R-XTR-212004", "name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_211939" ], "products": [ "species_113519", "species_113564", "species_211927" ], "modifiers": [ [ "species_10316428", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312207": { "compartment": "compartment_17960", "id": "reaction_10312207", "reactome": "R-XTR-76373", "name": "N-hydroxylation of 4-aminobiphenyl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_47687", "species_113601" ], "products": [ "species_113519", "species_113564", "species_34889" ], "modifiers": [ [ "species_10312204", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10312215": { "compartment": "compartment_17960", "id": "reaction_10312215", "reactome": "R-XTR-76426", "name": "N-atom dealkylation of caffeine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_40727", "species_113601" ], "products": [ "species_143501", "species_113519", "species_113564", "species_76424" ], "modifiers": [ [ "species_10312204", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10316426": { "compartment": "compartment_12045", "id": "reaction_10316426", "reactome": "R-XTR-211991", "name": "Cyclophosphamide is 4-hydroxylated by CYP2B6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211977", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211967" ], "modifiers": [ [ "species_10316423", "catalyst" ] ], "additional_components": [ "A0A6I8QHP5", "ENSXETG00000035878" ] }, "reaction_10316421": { "compartment": "compartment_12045", "id": "reaction_10316421", "reactome": "R-XTR-211988", "name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211855", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211937" ], "modifiers": [ [ "species_10316367", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312227": { "compartment": "compartment_12045", "id": "reaction_10312227", "reactome": "R-XTR-76472", "name": "Ethylene is oxidized to Ethylene oxide by CYP1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_38985", "species_113601" ], "products": [ "species_113519", "species_113564", "species_38987" ], "modifiers": [ [ "species_10312224", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10312217": { "compartment": "compartment_17960", "id": "reaction_10312217", "reactome": "R-XTR-76434", "name": "Dehalogenation of carbon tetrachloride to form a free radical", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40887" ], "products": [ "species_29572", "species_76433" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312200": { "compartment": "compartment_17960", "id": "reaction_10312200", "reactome": "R-XTR-76354", "name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_39417", "species_113601" ], "products": [ "species_156524", "species_113519", "species_113564" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312213": { "compartment": "compartment_17960", "id": "reaction_10312213", "reactome": "R-XTR-76416", "name": "Benzene is hydroxylated to phenol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_31711", "species_156540", "species_113601" ], "products": [ "species_113519", "species_29630", "species_113564" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312229": { "compartment": "compartment_17960", "id": "reaction_10312229", "reactome": "R-XTR-76475", "name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_40795", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76474", "species_76473" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312881": { "compartment": "compartment_17957", "id": "reaction_10312881", "reactome": "R-XTR-143468", "name": "MEOS oxidizes ethanol to acetaldehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113748", "species_113601" ], "products": [ "species_113519", "species_113564", "species_113745" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312211": { "compartment": "compartment_17957", "id": "reaction_10312211", "reactome": "R-XTR-76397", "name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_113564", "species_39427", "species_113555" ], "products": [ "species_113519", "species_76396", "species_113601" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10316354": { "compartment": "compartment_12045", "id": "reaction_10316354", "reactome": "R-XTR-211881", "name": "Coumarin is 7-hydroxylated by CYP2A13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_76328", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76452" ], "modifiers": [ [ "species_10316351", "catalyst" ] ], "additional_components": [ "F6SM60", "ENSXETT00000031981", "A0A6I8RC71", "ENSXETG00000024858", "A0A6I8Q180", "ENSXETG00000027561", "A0A6I8T1P2", "ENSXETG00000027556", "F6XRS5", "ENSXETT00000042326" ] }, "reaction_10316349": { "compartment": "compartment_17960", "id": "reaction_10316349", "reactome": "R-XTR-211874", "name": "CYP2S1 4-hydroxylates atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_215573", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215584" ], "modifiers": [ [ "species_10312173", "catalyst" ] ], "additional_components": [ "ENSXETG00000035878" ] }, "reaction_10316394": { "compartment": "compartment_17960", "id": "reaction_10316394", "reactome": "R-XTR-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_216620", "species_113519", "species_113564" ], "modifiers": [ [ "species_10316391", "catalyst" ] ], "additional_components": [ "ENSXETT00000042586" ] }, "reaction_10316419": { "compartment": "compartment_17960", "id": "reaction_10316419", "reactome": "R-XTR-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_216547" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10316416", "catalyst" ] ], "additional_components": [ "A0A6I8PZZ5", "ENSXETG00000034285", "F7AA19", "ENSXETT00000010485", "A0A6I8S3Z7", "ENSXETG00000034657", "A0A6I8QTX8", "ENSXETT00000010485", "A0A6I8Q285", "ENSXETG00000031264" ] }, "reaction_10316387": { "compartment": "compartment_17960", "id": "reaction_10316387", "reactome": "R-XTR-211959", "name": "CYP3A43 6b-hydroxylates TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30321", "species_113601" ], "products": [ "species_113519", "species_113564", "species_213144" ], "modifiers": [ [ "species_10316360", "catalyst" ] ], "additional_components": [ "A0A6I8Q6H5", "ENSXETT00000026362", "F7B981", "ENSXETT00000026362" ] }, "reaction_10314222": { "compartment": "compartment_70101", "id": "reaction_10314222", "reactome": "R-XTR-192061", "name": "CYP46A1 24-hydroxylates CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193384", "species_29368", "species_29364" ], "products": [ "species_192060", "species_29356", "species_29366" ], "modifiers": [ [ "species_10314219", "catalyst" ] ], "additional_components": [ "ENSXETG00000032861" ] }, "reaction_10314297": { "compartment": "compartment_5460", "id": "reaction_10314297", "reactome": "R-XTR-193997", "name": "CYP11B1 oxidises 11DCORT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_193998", "species_113529", "species_113600" ], "products": [ "species_113563", "species_194011", "species_113521" ], "modifiers": [ [ "species_10314289", "catalyst" ] ], "additional_components": [ "ENSXETG00000037871" ] }, "reaction_10314299": { "compartment": "compartment_5460", "id": "reaction_10314299", "reactome": "R-XTR-194017", "name": "CYP11B2 oxidises 11DCORST to CORST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_193988", "species_113600" ], "products": [ "species_113563", "species_194005", "species_113521" ], "modifiers": [ [ "species_10314289", "catalyst" ] ], "additional_components": [ "ENSXETG00000037871" ] }, "reaction_10314292": { "compartment": "compartment_5460", "id": "reaction_10314292", "reactome": "R-XTR-193965", "name": "CYP11B2 oxidises 18HCORST to ALDO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194012", "species_113533", "species_113529", "species_113600" ], "products": [ "species_193982", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314289", "catalyst" ] ], "additional_components": [ "ENSXETG00000037871" ] }, "reaction_10314294": { "compartment": "compartment_5460", "id": "reaction_10314294", "reactome": "R-XTR-193995", "name": "CYP11B2 18-hydroxylates CORST to 18HCORST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_194005", "species_113600" ], "products": [ "species_194012", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314289", "catalyst" ] ], "additional_components": [ "ENSXETG00000037871" ] }, "reaction_10316384": { "compartment": "compartment_70101", "id": "reaction_10316384", "reactome": "R-XTR-211951", "name": "CYP1B1 4-hydroxylates EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193132", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_211973" ], "modifiers": [ [ "species_10316381", "catalyst" ] ], "additional_components": [ "ENSXETG00000038590" ] }, "reaction_10314224": { "compartment": "compartment_5460", "id": "reaction_10314224", "reactome": "R-XTR-192123", "name": "CYP27A1 27-hydroxylates CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_193840", "species_113600" ], "products": [ "species_113563", "species_193846", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10331223": { "compartment": "compartment_70101", "id": "reaction_10331223", "reactome": "R-XTR-5692283", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692409", "species_29356", "species_29366" ], "products": [ "species_70106", "species_5692433", "species_29364" ], "modifiers": [ [ "species_10331220", "catalyst" ] ], "additional_components": [ "ENSXETT00000029530" ] }, "reaction_10331315": { "compartment": "compartment_17957", "id": "reaction_10331315", "reactome": "R-XTR-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_156540", "species_5693711", "species_5693712" ], "modifiers": [ [ "species_10331312", "catalyst" ] ], "additional_components": [ "A0A6I8Q0V4", "ENSXETG00000030902", "A0A5G3JDL4", "ENSXETT00000103127" ] }, "reaction_10336179": { "compartment": "compartment_70101", "id": "reaction_10336179", "reactome": "R-XTR-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10336176", "catalyst" ] ], "additional_components": [ "A0A5G3JDL4", "ENSXETT00000103127", "A0A6I8Q0V4", "ENSXETG00000030902" ] }, "reaction_10336114": { "compartment": "compartment_70101", "id": "reaction_10336114", "reactome": "R-XTR-8936442", "name": "MARC1,MARC2 reduce N-hydroxylated compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_8936443", "species_73473" ], "products": [ "species_29356", "species_29468", "species_29360" ], "modifiers": [ [ "species_10336111", "catalyst" ] ], "additional_components": [ "A0A1B8Y4Y6", "ENSXETT00000087008", "CHEBI:21437", "F6WBG7", "ENSXETT00000038708" ] }, "reaction_10329678": { "compartment": "compartment_70101", "id": "reaction_10329678", "reactome": "R-XTR-5423672", "name": "CYP1A2, 3A4 oxidise AFB1 to AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_5423605", "species_29364" ], "products": [ "species_5423663", "species_29356", "species_29366" ], "modifiers": [ [ "species_10329675", "catalyst" ] ], "additional_components": [ "A4IGV4", "ENSXETT00000061279", "F7B981", "ENSXETT00000026362", "A0A6I8Q6H5", "ENSXETT00000026362" ] }, "reaction_10329673": { "compartment": "compartment_70101", "id": "reaction_10329673", "reactome": "R-XTR-5423664", "name": "CYP3A4,5 hydroxylates AFB1 to AFQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_5423605", "species_29364" ], "products": [ "species_5423660", "species_29356", "species_29366" ], "modifiers": [ [ "species_10329670", "catalyst" ] ], "additional_components": [ "F7B981", "ENSXETT00000026362", "A0A6I8Q6H5", "ENSXETT00000026362" ] }, "reaction_10329707": { "compartment": "compartment_70101", "id": "reaction_10329707", "reactome": "R-XTR-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_2022890", "species_5490231" ], "modifiers": [ [ "species_10329704", "catalyst" ] ], "additional_components": [ "CHEBI:78580", "CHEBI:78585", "CHEBI:78583", "CHEBI:78578", "species_29426", "A0A6I8PUM5", "ENSXETG00000032120" ] }, "reaction_10329668": { "compartment": "compartment_70101", "id": "reaction_10329668", "reactome": "R-XTR-5423653", "name": "MGST trimers transfer GS from GSH to AFXBO and AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5423723" ], "products": [ "species_5423730" ], "modifiers": [ [ "species_10313607", "catalyst" ] ], "additional_components": [ "species_156523", "species_5423663", "CHEBI:78581", "CHEBI:78587", "A0A6I8RJ83", "ENSXETG00000036671", "F6PX96", "ENSXETT00000016673", "F6VC96", "ENSXETT00000010309" ] }, "reaction_10312902": { "compartment": "compartment_70101", "id": "reaction_10312902", "reactome": "R-XTR-156526", "name": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_5423605", "species_29364" ], "products": [ "species_29356", "species_159211", "species_29366" ], "modifiers": [ [ "species_10312899", "catalyst" ] ], "additional_components": [ "A4IGV4", "ENSXETT00000061279", "F7B981", "ENSXETT00000026362", "A0A6I8Q6H5", "ENSXETT00000026362", "F6SM60", "ENSXETT00000031981", "A0A6I8RC71", "ENSXETG00000024858", "A0A6I8Q180", "ENSXETG00000027561", "A0A6I8T1P2", "ENSXETG00000027556", "F6XRS5", "ENSXETT00000042326" ] }, "reaction_10337910": { "compartment": "compartment_70101", "id": "reaction_10337910", "reactome": "R-XTR-9638046", "name": "ACY3:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_2022890", "species_5490231" ], "modifiers": [ [ "species_10337907", "catalyst" ] ], "additional_components": [ "CHEBI:78580", "CHEBI:78585", "CHEBI:78583", "CHEBI:78578", "species_29426", "Q5BJ91", "ENSXETT00000019664" ] }, "reaction_10329680": { "compartment": "compartment_12045", "id": "reaction_10329680", "reactome": "R-XTR-5423678", "name": "CYP1A2 hydroxylates AFB1 to AFM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_5423605", "species_29364" ], "products": [ "species_5423629", "species_29356", "species_29366" ], "modifiers": [ [ "species_10312204", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10329666": { "compartment": "compartment_70101", "id": "reaction_10329666", "reactome": "R-XTR-5423647", "name": "CYP2A13 oxidises AFM1 to AFM1E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5423629", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_5423657", "species_29366" ], "modifiers": [ [ "species_10312195", "catalyst" ] ], "additional_components": [ "F6SM60", "ENSXETT00000031981", "A0A6I8RC71", "ENSXETG00000024858", "A0A6I8Q180", "ENSXETG00000027561", "A0A6I8T1P2", "ENSXETG00000027556", "F6XRS5", "ENSXETT00000042326" ] }, "reaction_10315625": { "compartment": "compartment_876", "id": "reaction_10315625", "reactome": "R-XTR-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10315622", "catalyst" ] ], "additional_components": [ "A0A6I8PTQ0", "ENSXETG00000014772", "F6TI71", "ENSXETT00000005158" ] }, "reaction_10314029": { "compartment": "compartment_7660", "id": "reaction_10314029", "reactome": "R-XTR-187937", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314001", "species_10314025" ], "products": [ "species_10314027" ], "modifiers": [], "additional_components": [ "F6T0J1", "ENSXETT00000046130", "ENSXETG00000000021", "A0A6I8QJI3", "ENSXETG00000000021", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10314040": { "compartment": "compartment_7660", "id": "reaction_10314040", "reactome": "R-XTR-187959", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10314027" ], "products": [ "species_113582", "species_10314037" ], "modifiers": [ [ "species_10314027", "catalyst" ] ], "additional_components": [ "A0A6I8QJI3", "ENSXETG00000000021", "F6T0J1", "ENSXETT00000046130", "F6T0J1", "ENSXETT00000046130", "A0A6I8QJI3", "ENSXETG00000000021", "A0A6I8QJI3", "ENSXETG00000000021", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10327234": { "compartment": "compartment_70101", "id": "reaction_10327234", "reactome": "R-XTR-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327232" ], "products": [ "species_10313135" ], "modifiers": [], "additional_components": [ "ENSXETT00000022754", "ENSXETT00000022754" ] }, "reaction_10328464": { "compartment": "compartment_7660", "id": "reaction_10328464", "reactome": "R-XTR-4088024", "name": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10328459" ], "products": [ "species_113582", "species_10328462" ], "modifiers": [ [ "species_10314001", "catalyst" ] ], "additional_components": [ "ENSXETG00000035621", "ENSXETG00000035621", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10335127": { "compartment": "compartment_70101", "id": "reaction_10335127", "reactome": "R-XTR-8852331", "name": "GTSE1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335118" ], "products": [ "species_10335125" ], "modifiers": [], "additional_components": [ "ENSXETT00000061292", "ENSXETT00000061292" ] }, "reaction_10335121": { "compartment": "compartment_70101", "id": "reaction_10335121", "reactome": "R-XTR-8852317", "name": "PLK1 phosphorylates GTSE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10335115" ], "products": [ "species_10327232", "species_29370", "species_10335118" ], "modifiers": [ [ "species_10335115", "catalyst" ] ], "additional_components": [ "Q28DF6", "ENSXETT00000061292", "P62205", "ENSXETT00000022754", "ENSXETT00000022754", "ENSXETT00000061292", "Q28DF6", "ENSXETT00000061292", "P62205", "ENSXETT00000022754" ] }, "reaction_10335123": { "compartment": "compartment_70101", "id": "reaction_10335123", "reactome": "R-XTR-8852324", "name": "GTSE1 binds PLK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327232", "species_10335113" ], "products": [ "species_10335115" ], "modifiers": [], "additional_components": [ "ENSXETT00000022754", "ENSXETT00000061292", "Q28DF6", "ENSXETT00000061292", "P62205", "ENSXETT00000022754" ] }, "reaction_10328475": { "compartment": "compartment_7660", "id": "reaction_10328475", "reactome": "R-XTR-4088134", "name": "PLK1 phosphorylates FOXM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328466", "species_29358" ], "products": [ "species_113582", "species_10328472", "species_10313135" ], "modifiers": [ [ "species_10328466", "catalyst" ] ], "additional_components": [ "P62205", "ENSXETT00000022754", "A0A6I8RBK3", "ENSXETG00000035621", "ENSXETG00000035621", "ENSXETT00000022754", "P62205", "ENSXETT00000022754", "A0A6I8RBK3", "ENSXETG00000035621" ] }, "reaction_10328468": { "compartment": "compartment_7660", "id": "reaction_10328468", "reactome": "R-XTR-4088130", "name": "PLK1 binds FOXM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328462", "species_10313135" ], "products": [ "species_10328466" ], "modifiers": [], "additional_components": [ "ENSXETG00000035621", "ENSXETT00000022754", "P62205", "ENSXETT00000022754", "A0A6I8RBK3", "ENSXETG00000035621" ] }, "reaction_10324271": { "compartment": "compartment_70101", "id": "reaction_10324271", "reactome": "R-XTR-1855216", "name": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_29370", "species_1629740" ], "modifiers": [ [ "species_10324253", "catalyst" ] ], "additional_components": [ "ENSXETT00000018584" ] }, "reaction_10324302": { "compartment": "compartment_70101", "id": "reaction_10324302", "reactome": "R-XTR-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_1629765", "species_29370" ], "modifiers": [ [ "species_10324235", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324296": { "compartment": "compartment_70101", "id": "reaction_10324296", "reactome": "R-XTR-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10324235", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324262": { "compartment": "compartment_70101", "id": "reaction_10324262", "reactome": "R-XTR-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10324235", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324240": { "compartment": "compartment_70101", "id": "reaction_10324240", "reactome": "R-XTR-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10324235", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324256": { "compartment": "compartment_70101", "id": "reaction_10324256", "reactome": "R-XTR-1855182", "name": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10324253", "catalyst" ] ], "additional_components": [ "ENSXETT00000018584" ] }, "reaction_10324259": { "compartment": "compartment_70101", "id": "reaction_10324259", "reactome": "R-XTR-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10324235", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10331934": { "compartment": "compartment_70101", "id": "reaction_10331934", "reactome": "R-XTR-5696627", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10331927" ], "products": [ "species_10331931", "species_10313391" ], "modifiers": [ [ "species_10331927", "catalyst" ] ], "additional_components": [ "A0A6I8SGS6", "ENSXETG00000031250", "A0A6I8RKP9", "ENSXETG00000031817", "Q28DL4", "ENSXETG00000007549", "A0A6I8RKP9", "ENSXETG00000031817", "Q28DL4", "ENSXETG00000007549", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8SGS6", "ENSXETG00000031250", "A0A6I8RKP9", "ENSXETG00000031817", "Q28DL4", "ENSXETG00000007549" ] }, "reaction_10320632": { "compartment": "compartment_70101", "id": "reaction_10320632", "reactome": "R-XTR-936390", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320623" ], "products": [ "species_10320625", "species_10312116" ], "modifiers": [ [ "species_10320629", "catalyst" ] ], "additional_components": [ "ENSXETG00000009200", "ENSXETG00000009200", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "ENSXETG00000031250" ] }, "reaction_10331914": { "compartment": "compartment_7660", "id": "reaction_10331914", "reactome": "R-XTR-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10331767" ], "products": [ "species_10331911", "species_10331769" ], "modifiers": [ [ "species_10331767", "catalyst" ] ], "additional_components": [ "A0A6I8RK73", "ENSXETG00000005089", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8RK73", "ENSXETG00000005089", "A0A6I8RK73", "ENSXETG00000005089" ] }, "reaction_10332196": { "compartment": "compartment_17906", "id": "reaction_10332196", "reactome": "R-XTR-5696872", "name": "USP30 deubiquitinates Ub-MOM proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10331979" ], "products": [ "species_10332193", "species_10331995" ], "modifiers": [ [ "species_10331979", "catalyst" ] ], "additional_components": [ "Q6DFM9", "ENSXETT00000098526", "A4QNN3", "ENSXETT00000048254", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q6DFM9", "ENSXETT00000098526", "A4QNN3", "ENSXETT00000048254", "Q6DFM9", "ENSXETT00000098526", "A4QNN3", "ENSXETT00000048254" ] }, "reaction_10330999": { "compartment": "compartment_7660", "id": "reaction_10330999", "reactome": "R-XTR-5690157", "name": "USP16,USP21 deubiquitinate Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10330994" ], "products": [ "species_10327687", "species_10330996" ], "modifiers": [ [ "species_10330994", "catalyst" ] ], "additional_components": [ "Q0VA64", "ENSXETG00000020255", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q0VA64", "ENSXETG00000020255", "Q0VA64", "ENSXETG00000020255" ] }, "reaction_10332214": { "compartment": "compartment_7660", "id": "reaction_10332214", "reactome": "R-XTR-5696997", "name": "USP24 deubiquitinates DDB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10332207" ], "products": [ "species_10332211", "species_10331911" ], "modifiers": [ [ "species_10332207", "catalyst" ] ], "additional_components": [ "Q66JG1", "ENSXETT00000008619", "A0A6I8SCT2", "ENSXETG00000009543", "A0A6I8SCT2", "ENSXETG00000009543", "Q66JG1", "ENSXETT00000008619", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q66JG1", "ENSXETT00000008619", "A0A6I8SCT2", "ENSXETG00000009543" ] }, "reaction_10331760": { "compartment": "compartment_70101", "id": "reaction_10331760", "reactome": "R-XTR-5696600", "name": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10331549" ], "products": [ "species_10331555", "species_10331757" ], "modifiers": [ [ "species_10331549", "catalyst" ] ], "additional_components": [ "F7BNK9", "ENSXETT00000015033", "A0A6I8SFY9", "ENSXETG00000009200", "B7ZT68", "ENSXETT00000056088", "F7BNK9", "ENSXETT00000015033", "B7ZT68", "ENSXETT00000056088", "A0A6I8SFY9", "ENSXETG00000009200", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7BNK9", "ENSXETT00000015033", "A0A6I8SFY9", "ENSXETG00000009200", "B7ZT68", "ENSXETT00000056088" ] }, "reaction_10331173": { "compartment": "compartment_70101", "id": "reaction_10331173", "reactome": "R-XTR-5691439", "name": "BRISC complex deubiquitinates NLRP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10331164" ], "products": [ "species_10331168", "species_10313391" ], "modifiers": [ [ "species_10331164", "catalyst" ] ], "additional_components": [ "Q5M8J0", "ENSXETG00000025571", "Q4VA72", "ENSXETG00000026184", "Q6P4W0", "ENSXETG00000023627", "Q6DJ78", "ENSXETG00000010201", "Q5M8J0", "ENSXETG00000025571", "Q4VA72", "ENSXETG00000026184", "Q6P4W0", "ENSXETG00000023627", "Q6DJ78", "ENSXETG00000010201", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q5M8J0", "ENSXETG00000025571", "Q4VA72", "ENSXETG00000026184", "Q6P4W0", "ENSXETG00000023627", "Q6DJ78", "ENSXETG00000010201" ] }, "reaction_10331071": { "compartment": "compartment_7660", "id": "reaction_10331071", "reactome": "R-XTR-5690759", "name": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10331006" ], "products": [ "species_10331010", "species_10331068" ], "modifiers": [ [ "species_10331006", "catalyst" ] ], "additional_components": [ "A0A6I8QTP5", "ENSXETG00000014251", "Q66JB6", "ENSXETG00000000091", "Q66JB6", "ENSXETG00000000091", "A0A6I8QTP5", "ENSXETG00000014251", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8QTP5", "ENSXETG00000014251", "Q66JB6", "ENSXETG00000000091" ] }, "reaction_10331073": { "compartment": "compartment_7660", "id": "reaction_10331073", "reactome": "R-XTR-5690785", "name": "BAP1 binds Ub-HCFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330919", "species_10331004" ], "products": [ "species_10331006" ], "modifiers": [], "additional_components": [ "ENSXETG00000000091", "ENSXETG00000014251", "A0A6I8QTP5", "ENSXETG00000014251", "Q66JB6", "ENSXETG00000000091" ] }, "reaction_10335867": { "compartment": "compartment_70101", "id": "reaction_10335867", "reactome": "R-XTR-8869506", "name": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10335864" ], "products": [ "species_10331090", "species_10313391" ], "modifiers": [ [ "species_10335864", "catalyst" ] ], "additional_components": [ "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765", "Q28DL4", "ENSXETG00000007549", "Q28DL4", "ENSXETG00000007549", "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765", "Q28DL4", "ENSXETG00000007549" ] }, "reaction_10331093": { "compartment": "compartment_70101", "id": "reaction_10331093", "reactome": "R-XTR-5690870", "name": "OTUD7B,TNFAIP3 deubiquitinate TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331088", "species_29356" ], "products": [ "species_10331090", "species_10330519" ], "modifiers": [ [ "species_10331088", "catalyst" ] ], "additional_components": [ "Q28DL4", "ENSXETG00000007549", "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765", "Q28DL4", "ENSXETG00000007549", "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q28DL4", "ENSXETG00000007549", "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765" ] }, "reaction_10330909": { "compartment": "compartment_70101", "id": "reaction_10330909", "reactome": "R-XTR-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10313391" ], "products": [ "species_10313391", "species_10313389" ], "modifiers": [ [ "species_10330906", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "ENSXETT00000006019" ] }, "reaction_10325869": { "compartment": "compartment_70101", "id": "reaction_10325869", "reactome": "R-XTR-2038398", "name": "KIBRA (WWC1) binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325797", "species_10325865" ], "products": [ "species_10325867" ], "modifiers": [], "additional_components": [ "ENSXETT00000026288", "ENSXETG00000016462", "A4IIJ3", "ENSXETG00000016462", "F6U2R0", "ENSXETT00000026288" ] }, "reaction_10325851": { "compartment": "compartment_70101", "id": "reaction_10325851", "reactome": "R-XTR-2032770", "name": "Translocation of YAP1 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325815" ], "products": [ "species_10325849" ], "modifiers": [], "additional_components": [ "ENSXETG00000032689", "ENSXETG00000032689" ] }, "reaction_10325835": { "compartment": "compartment_70101", "id": "reaction_10325835", "reactome": "R-XTR-2028644", "name": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312802", "species_10325818" ], "products": [ "species_10325833" ], "modifiers": [], "additional_components": [ "Q5XGC8", "ENSXETG00000022830", "ENSXETG00000032689", "A0A6I8SYU4", "ENSXETG00000032689", "Q5XGC8", "ENSXETG00000022830" ] }, "reaction_10325829": { "compartment": "compartment_70101", "id": "reaction_10325829", "reactome": "R-XTR-2028626", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325797", "species_10325803" ], "products": [ "species_10325805" ], "modifiers": [], "additional_components": [ "ENSXETT00000026288", "ENSXETT00000073958", "Q28FB5", "ENSXETT00000073958", "F6U2R0", "ENSXETT00000026288" ] }, "reaction_10325942": { "compartment": "compartment_70101", "id": "reaction_10325942", "reactome": "R-XTR-2059926", "name": "NPHP4 protein binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325938", "species_10325797" ], "products": [ "species_10325940" ], "modifiers": [], "additional_components": [ "ENSXETG00000002886", "ENSXETT00000026288", "F6U2R0", "ENSXETT00000026288", "A0A6I8SDY8", "ENSXETG00000002886" ] }, "reaction_10325843": { "compartment": "compartment_70101", "id": "reaction_10325843", "reactome": "R-XTR-2028724", "name": "AMOT proteins bind YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325815", "species_10325839" ], "products": [ "species_10325841" ], "modifiers": [], "additional_components": [ "ENSXETG00000032689", "ENSXETG00000006385", "A0A6I8SVS3", "ENSXETG00000006385", "A0A6I8SYU4", "ENSXETG00000032689" ] }, "reaction_10325827": { "compartment": "compartment_70101", "id": "reaction_10325827", "reactome": "R-XTR-2028598", "name": "Phosphorylation of YAP by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325815", "species_113592" ], "products": [ "species_10325824", "species_29370" ], "modifiers": [ [ "species_10325811", "catalyst" ] ], "additional_components": [ "ENSXETG00000032689", "ENSXETG00000032689", "Q28FB5", "ENSXETT00000073958", "F6U2R0", "ENSXETT00000026288" ] }, "reaction_10335596": { "compartment": "compartment_876", "id": "reaction_10335596", "reactome": "R-XTR-8858498", "name": "SL (surrogate light chain) binds IgH to form pre-BCR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335536", "species_10335592" ], "products": [ "species_10335594" ], "modifiers": [], "additional_components": [ "A0A6I8QLS0", "ENSXETG00000041230", "A0A6I8QM25", "ENSXETG00000041230", "A0A6I8PTS9", "ENSXETG00000041230", "A0A6I8RSN1", "ENSXETG00000041230", "A0A6I8PUH7", "ENSXETG00000041230", "A0A6I8S9Z8", "ENSXETG00000041230", "A0A6I8PM56", "ENSXETG00000041230", "A0A6I8RJH0", "ENSXETG00000041230", "A0A6I8PMK7", "ENSXETG00000041230", "A0A6I8RS78", "ENSXETG00000041230", "A0A6I8R4R2", "ENSXETG00000041230", "A0A6I8R767", "ENSXETG00000041230", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8RSK9", "ENSXETG00000040383", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8QKP4", "ENSXETG00000040212", "A0A6I8SYV6", "ENSXETG00000040212", "A0A6I8RUJ4", "ENSXETG00000040212", "A0A6I8SK71", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8RNX1", "ENSXETG00000040212", "A0A6I8QZL1", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212", "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8R2R2", "ENSXETG00000039428", "A0A6I8RZZ7", "ENSXETG00000039428", "A0A6I8QD99", "ENSXETG00000039428", "A0A6I8QNA7", "ENSXETG00000039428", "A0A6I8Q2V3", "ENSXETG00000039428", "A0A6I8Q7C1", "ENSXETG00000039428", "A0A6I8SEP6", "ENSXETG00000039428", "A0A6I8PSU3", "ENSXETG00000039428", "F6S2S6", "ENSXETT00000022997", "A0A6I8QGS1", "ENSXETG00000040831", "A0A6I8SZD5", "ENSXETG00000034688", "A0A6I8QDF6", "ENSXETG00000037057", "A0A6I8S531", "ENSXETG00000040831", "A0A6I8Q881", "ENSXETG00000040831", "A0A6I8RG89", "ENSXETG00000040831", "A0A6I8R6G0", "ENSXETG00000040853", "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8R2R2", "ENSXETG00000039428", "A0A6I8RZZ7", "ENSXETG00000039428", "A0A6I8QD99", "ENSXETG00000039428", "A0A6I8QNA7", "ENSXETG00000039428", "A0A6I8Q2V3", "ENSXETG00000039428", "A0A6I8Q7C1", "ENSXETG00000039428", "A0A6I8SEP6", "ENSXETG00000039428", "A0A6I8PSU3", "ENSXETG00000039428", "F6S2S6", "ENSXETT00000022997", "A0A6I8QGS1", "ENSXETG00000040831", "A0A6I8SZD5", "ENSXETG00000034688", "A0A6I8QDF6", "ENSXETG00000037057", "A0A6I8S531", "ENSXETG00000040831", "A0A6I8Q881", "ENSXETG00000040831", "A0A6I8RG89", "ENSXETG00000040831", "A0A6I8R6G0", "ENSXETG00000040853", "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8QLS0", "ENSXETG00000041230", "A0A6I8QM25", "ENSXETG00000041230", "A0A6I8PTS9", "ENSXETG00000041230", "A0A6I8RSN1", "ENSXETG00000041230", "A0A6I8PUH7", "ENSXETG00000041230", "A0A6I8S9Z8", "ENSXETG00000041230", "A0A6I8PM56", "ENSXETG00000041230", "A0A6I8RJH0", "ENSXETG00000041230", "A0A6I8PMK7", "ENSXETG00000041230", "A0A6I8RS78", "ENSXETG00000041230", "A0A6I8R4R2", "ENSXETG00000041230", "A0A6I8R767", "ENSXETG00000041230", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8RSK9", "ENSXETG00000040383", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8QKP4", "ENSXETG00000040212", "A0A6I8SYV6", "ENSXETG00000040212", "A0A6I8RUJ4", "ENSXETG00000040212", "A0A6I8SK71", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8RNX1", "ENSXETG00000040212", "A0A6I8QZL1", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212" ] }, "reaction_10315803": { "compartment": "compartment_876", "id": "reaction_10315803", "reactome": "R-XTR-202717", "name": "Heterodimerization of CEACAMs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315799" ], "products": [ "species_10315801" ], "modifiers": [], "additional_components": [ "A0A6I8QZM7", "ENSXETG00000032631", "A0A6I8R329", "ENSXETG00000038658", "A0A6I8PPZ5", "ENSXETG00000038658", "A0A6I8SB02", "ENSXETG00000038658", "A0A6I8QZM7", "ENSXETG00000032631", "A0A6I8R329", "ENSXETG00000038658", "A0A6I8PPZ5", "ENSXETG00000038658", "A0A6I8SB02", "ENSXETG00000038658" ] }, "reaction_10327047": { "compartment": "compartment_876", "id": "reaction_10327047", "reactome": "R-XTR-2870221", "name": "E-selectin binds E-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315815", "species_10315821" ], "products": [ "species_10327045" ], "modifiers": [], "additional_components": [ "ENSXETG00000038109", "ENSXETG00000039556", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8R2I7", "ENSXETG00000038109" ] }, "reaction_10315831": { "compartment": "compartment_876", "id": "reaction_10315831", "reactome": "R-XTR-202731", "name": "JAM3 dimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315807" ], "products": [ "species_10315829" ], "modifiers": [], "additional_components": [ "ENSXETG00000040710", "A0A6I8SUC1", "ENSXETG00000040710" ] }, "reaction_10335414": { "compartment": "compartment_876", "id": "reaction_10335414", "reactome": "R-XTR-8858428", "name": "FCAMR binds IgA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335410", "species_10326437" ], "products": [ "species_10335412" ], "modifiers": [], "additional_components": [ "ENSXETG00000037809", "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8QLS0", "ENSXETG00000041230", "A0A6I8QM25", "ENSXETG00000041230", "A0A6I8PTS9", "ENSXETG00000041230", "A0A6I8RSN1", "ENSXETG00000041230", "A0A6I8PUH7", "ENSXETG00000041230", "A0A6I8S9Z8", "ENSXETG00000041230", "A0A6I8PM56", "ENSXETG00000041230", "A0A6I8RJH0", "ENSXETG00000041230", "A0A6I8PMK7", "ENSXETG00000041230", "A0A6I8RS78", "ENSXETG00000041230", "A0A6I8R4R2", "ENSXETG00000041230", "A0A6I8R767", "ENSXETG00000041230", "A0A6I8RSK9", "ENSXETG00000040383", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212", "A0A6I8SK71", "ENSXETG00000040212", "A0A6I8QZL1", "ENSXETG00000040212", "A0A6I8RUJ4", "ENSXETG00000040212", "A0A6I8QKP4", "ENSXETG00000040212", "A0A6I8RNX1", "ENSXETG00000040212", "A0A6I8SYV6", "ENSXETG00000040212", "A0A6I8PWK1", "ENSXETT00000069302", "A0A6I8PXL5", "ENSXETT00000069302", "A0A5G3K4A2", "ENSXETT00000069302", "F7ATU6", "ENSXETT00000069302", "A0A6I8PNW8", "ENSXETT00000069302", "L7N2W1", "ENSXETT00000013311", "A0A6I8SSF0", "ENSXETT00000069302", "A0A6I8SYX6", "ENSXETT00000069302", "A0A6I8SF25", "ENSXETT00000069302", "A0A6I8SJ82", "ENSXETT00000069302", "A0A6I8SCS2", "ENSXETT00000069302", "A0A6I8SCZ9", "ENSXETT00000069302", "A0A6I8S4K2", "ENSXETT00000069302", "A0A6I8S824", "ENSXETT00000069302", "A0A6I8S1H6", "ENSXETT00000069302", "A0A6I8S3H5", "ENSXETT00000069302", "A0A6I8RTG9", "ENSXETT00000069302", "A0A6I8RYE0", "ENSXETT00000069302", "A0A6I8RLS5", "ENSXETT00000069302", "A0A6I8RQ73", "ENSXETT00000069302", "A0A6I8RDF6", "ENSXETT00000069302", "A0A6I8RF32", "ENSXETT00000069302", "A0A6I8R2N8", "ENSXETT00000069302", "A0A6I8R7C6", "ENSXETT00000069302", "A0A6I8QNF8", "ENSXETT00000069302", "A0A6I8QSF1", "ENSXETT00000069302", "A0A6I8QE50", "ENSXETT00000069302", "A0A6I8QMZ7", "ENSXETT00000069302", "A0A6I8Q652", "ENSXETT00000069302", "A0A6I8Q664", "ENSXETT00000069302", "A0A6I8Q2X0", "ENSXETT00000069302", "A0A6I8Q318", "ENSXETT00000069302", "A0A6I8Q0S1", "ENSXETT00000069302", "A0A6I8Q2I9", "ENSXETT00000069302", "K9J7P7", "ENSXETT00000007797", "A0A6I8PSU3", "ENSXETG00000039428", "F6S2S6", "ENSXETT00000022997", "A0A6I8Q2V3", "ENSXETG00000039428", "A0A6I8RZZ7", "ENSXETG00000039428", "A0A6I8SEP6", "ENSXETG00000039428", "A0A6I8QNA7", "ENSXETG00000039428", "A0A6I8R2R2", "ENSXETG00000039428", "A0A6I8Q7C1", "ENSXETG00000039428", "A0A6I8QD99", "ENSXETG00000039428", "A0A6I8R5U7", "ENSXETG00000034776", "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8QLS0", "ENSXETG00000041230", "A0A6I8QM25", "ENSXETG00000041230", "A0A6I8PTS9", "ENSXETG00000041230", "A0A6I8RSN1", "ENSXETG00000041230", "A0A6I8PUH7", "ENSXETG00000041230", "A0A6I8S9Z8", "ENSXETG00000041230", "A0A6I8PM56", "ENSXETG00000041230", "A0A6I8RJH0", "ENSXETG00000041230", "A0A6I8PMK7", "ENSXETG00000041230", "A0A6I8RS78", "ENSXETG00000041230", "A0A6I8R4R2", "ENSXETG00000041230", "A0A6I8R767", "ENSXETG00000041230", "A0A6I8RSK9", "ENSXETG00000040383", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212", "A0A6I8SK71", "ENSXETG00000040212", "A0A6I8QZL1", "ENSXETG00000040212", "A0A6I8RUJ4", "ENSXETG00000040212", "A0A6I8QKP4", "ENSXETG00000040212", "A0A6I8RNX1", "ENSXETG00000040212", "A0A6I8SYV6", "ENSXETG00000040212", "A0A6I8PWK1", "ENSXETT00000069302", "A0A6I8PXL5", "ENSXETT00000069302", "A0A5G3K4A2", "ENSXETT00000069302", "F7ATU6", "ENSXETT00000069302", "A0A6I8PNW8", "ENSXETT00000069302", "L7N2W1", "ENSXETT00000013311", "A0A6I8SSF0", "ENSXETT00000069302", "A0A6I8SYX6", "ENSXETT00000069302", "A0A6I8SF25", "ENSXETT00000069302", "A0A6I8SJ82", "ENSXETT00000069302", "A0A6I8SCS2", "ENSXETT00000069302", "A0A6I8SCZ9", "ENSXETT00000069302", "A0A6I8S4K2", "ENSXETT00000069302", "A0A6I8S824", "ENSXETT00000069302", "A0A6I8S1H6", "ENSXETT00000069302", "A0A6I8S3H5", "ENSXETT00000069302", "A0A6I8RTG9", "ENSXETT00000069302", "A0A6I8RYE0", "ENSXETT00000069302", "A0A6I8RLS5", "ENSXETT00000069302", "A0A6I8RQ73", "ENSXETT00000069302", "A0A6I8RDF6", "ENSXETT00000069302", "A0A6I8RF32", "ENSXETT00000069302", "A0A6I8R2N8", "ENSXETT00000069302", "A0A6I8R7C6", "ENSXETT00000069302", "A0A6I8QNF8", "ENSXETT00000069302", "A0A6I8QSF1", "ENSXETT00000069302", "A0A6I8QE50", "ENSXETT00000069302", "A0A6I8QMZ7", "ENSXETT00000069302", "A0A6I8Q652", "ENSXETT00000069302", "A0A6I8Q664", "ENSXETT00000069302", "A0A6I8Q2X0", "ENSXETT00000069302", "A0A6I8Q318", "ENSXETT00000069302", "A0A6I8Q0S1", "ENSXETT00000069302", "A0A6I8Q2I9", "ENSXETT00000069302", "K9J7P7", "ENSXETT00000007797", "A0A6I8PSU3", "ENSXETG00000039428", "F6S2S6", "ENSXETT00000022997", "A0A6I8Q2V3", "ENSXETG00000039428", "A0A6I8RZZ7", "ENSXETG00000039428", "A0A6I8SEP6", "ENSXETG00000039428", "A0A6I8QNA7", "ENSXETG00000039428", "A0A6I8R2R2", "ENSXETG00000039428", "A0A6I8Q7C1", "ENSXETG00000039428", "A0A6I8QD99", "ENSXETG00000039428", "A0A6I8R5U7", "ENSXETG00000034776", "A0A6I8QSY3", "ENSXETG00000037809" ] }, "reaction_10335808": { "compartment": "compartment_876", "id": "reaction_10335808", "reactome": "R-XTR-8867240", "name": "EPCAM binds itself to form homotypic cell adhesion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335804" ], "products": [ "species_10335806" ], "modifiers": [], "additional_components": [ "ENSXETT00000060362", "Q5U4Z2", "ENSXETT00000060362" ] }, "reaction_10315827": { "compartment": "compartment_876", "id": "reaction_10315827", "reactome": "R-XTR-202724", "name": "P-selectin binds P-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315815", "species_10315823" ], "products": [ "species_10315825" ], "modifiers": [], "additional_components": [ "ENSXETG00000038109", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8R2I7", "ENSXETG00000038109" ] }, "reaction_10327054": { "compartment": "compartment_984", "id": "reaction_10327054", "reactome": "R-XTR-2872444", "name": "SLC9B1/C2 exchange Na+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10327051", "catalyst" ] ], "additional_components": [ "ENSXETG00000021321" ] }, "reaction_10327555": { "compartment": "compartment_70101", "id": "reaction_10327555", "reactome": "R-XTR-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10327552", "catalyst" ] ], "additional_components": [ "A0A6I8QKQ2", "ENSXETG00000031787", "A0A6I8SES7", "ENSXETG00000005811", "A0A6I8SY50", "ENSXETG00000001048", "A0A6I8RF46", "ENSXETG00000008633" ] }, "reaction_10327002": { "compartment": "compartment_70101", "id": "reaction_10327002", "reactome": "R-XTR-2671885", "name": "ASIC trimers:H+ transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10326999", "catalyst" ], [ "species_2672379", "inhibitor" ], [ "species_2672383", "inhibitor" ] ], "additional_components": [ "F6W3B8", "ENSXETT00000027176", "species_156540" ] }, "reaction_10335653": { "compartment": "compartment_876", "id": "reaction_10335653", "reactome": "R-XTR-8863494", "name": "ASICs bind STOML3, (STOM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335649", "species_10326999" ], "products": [ "species_10335651" ], "modifiers": [], "additional_components": [ "ENSXETT00000104043", "F6W3B8", "ENSXETT00000027176", "species_156540", "F6W3B8", "ENSXETT00000027176", "species_156540", "A0A1B8Y5B7", "ENSXETT00000104043" ] }, "reaction_10338020": { "compartment": "compartment_876", "id": "reaction_10338020", "reactome": "R-XTR-9650165", "name": "ASIC trimers bind H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338018", "species_351626" ], "products": [ "species_10326999" ], "modifiers": [], "additional_components": [ "F6W3B8", "ENSXETT00000027176", "F6W3B8", "ENSXETT00000027176", "species_156540" ] }, "reaction_10327041": { "compartment": "compartment_70101", "id": "reaction_10327041", "reactome": "R-XTR-2744349", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10327038", "catalyst" ] ], "additional_components": [ "ENSXETG00000003389" ] }, "reaction_10327027": { "compartment": "compartment_70101", "id": "reaction_10327027", "reactome": "R-XTR-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10327018", "catalyst" ], [ "species_10327023", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "A0A6I8SNU5", "ENSXETG00000031444", "A0A6I8SCS5", "ENSXETG00000034667", "A0A6I8PYE3", "ENSXETG00000031447", "ENSXETG00000039090" ] }, "reaction_10329555": { "compartment": "compartment_876", "id": "reaction_10329555", "reactome": "R-XTR-5333671", "name": "CLCAs self cleave", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329542" ], "products": [ "species_10327023", "species_10329548" ], "modifiers": [ [ "species_10329542", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "ENSXETG00000039090", "ENSXETG00000039090", "ENSXETG00000039090", "ENSXETG00000039090" ] }, "reaction_10327059": { "compartment": "compartment_17927", "id": "reaction_10327059", "reactome": "R-XTR-2889070", "name": "SLC9B2 exchanges Na+, Li+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_2889081" ], "products": [ "species_2889062", "species_163953" ], "modifiers": [ [ "species_10327056", "catalyst" ] ], "additional_components": [ "species_74113", "species_8953505", "species_8953505", "species_74113", "ENSXETG00000021321" ] }, "reaction_10325871": { "compartment": "compartment_12045", "id": "reaction_10325871", "reactome": "R-XTR-2046083", "name": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046053", "species_113601" ], "products": [ "species_113519", "species_162743", "species_159751", "species_2046060" ], "modifiers": [ [ "species_10319021", "catalyst" ] ], "additional_components": [ "ENSXETT00000034904" ] }, "reaction_10325880": { "compartment": "compartment_17957", "id": "reaction_10325880", "reactome": "R-XTR-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_113519", "species_113564", "species_162743", "species_159751", "species_2046045" ], "modifiers": [ [ "species_10319021", "catalyst" ] ], "additional_components": [ "ENSXETT00000034904" ] }, "reaction_10325878": { "compartment": "compartment_12045", "id": "reaction_10325878", "reactome": "R-XTR-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_5228339", "species_2046055", "species_211606" ], "modifiers": [ [ "species_10317279", "catalyst" ] ], "additional_components": [ "ENSXETG00000007705" ] }, "reaction_10320759": { "compartment": "compartment_876", "id": "reaction_10320759", "reactome": "R-XTR-975449", "name": "GABRR pentamers:GABA transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10320756", "catalyst" ] ], "additional_components": [ "species_428571", "A0A6I8QVR1", "ENSXETG00000030855" ] }, "reaction_10320748": { "compartment": "compartment_876", "id": "reaction_10320748", "reactome": "R-XTR-975311", "name": "HTR3 pentamers:5HT transport Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_74112", "species_74113" ], "products": [ "species_29804", "species_83910", "species_74016" ], "modifiers": [ [ "species_10320745", "catalyst" ] ], "additional_components": [ "species_114523", "A0A6I8QAS1", "ENSXETG00000031115", "A0A6I8RJM1", "ENSXETG00000031022" ] }, "reaction_10338012": { "compartment": "compartment_876", "id": "reaction_10338012", "reactome": "R-XTR-9648983", "name": "HTR3A pentamer:5HT transports Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_74112", "species_74113" ], "products": [ "species_29804", "species_83910", "species_74016" ], "modifiers": [ [ "species_10338009", "catalyst" ] ], "additional_components": [ "A0A6I8QAS1", "ENSXETG00000031115", "species_114523" ] }, "reaction_10337600": { "compartment": "compartment_7660", "id": "reaction_10337600", "reactome": "R-XTR-9029434", "name": "p-S363,S380,T573 RS6K translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337590" ], "products": [ "species_10337598" ], "modifiers": [], "additional_components": [ "F7DTA9", "ENSXETT00000051850", "F6YXI9", "ENSXETT00000008599", "F6YXI9", "ENSXETT00000008599", "F7DTA9", "ENSXETT00000051850" ] }, "reaction_10338016": { "compartment": "compartment_876", "id": "reaction_10338016", "reactome": "R-XTR-9649108", "name": "HTR3A pentamer binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10338014" ], "products": [ "species_10338009" ], "modifiers": [], "additional_components": [ "A0A6I8QAS1", "ENSXETG00000031115", "A0A6I8QAS1", "ENSXETG00000031115", "species_114523" ] }, "reaction_10316794": { "compartment": "compartment_374932", "id": "reaction_10316794", "reactome": "R-XTR-372542", "name": "Loading of dopamine into synaptic veiscles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159362" ], "products": [ "species_351601" ], "modifiers": [ [ "species_10316791", "catalyst" ] ], "additional_components": [ "ENSXETG00000038313" ] }, "reaction_10317198": { "compartment": "compartment_374932", "id": "reaction_10317198", "reactome": "R-XTR-380586", "name": "loading of Serotonin in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209914" ], "products": [ "species_380585" ], "modifiers": [ [ "species_10316791", "catalyst" ] ], "additional_components": [ "ENSXETG00000038313" ] }, "reaction_10333989": { "compartment": "compartment_161320", "id": "reaction_10333989", "reactome": "R-XTR-6803753", "name": "NAAA hydrolyses NAEs to FAs and ethanolamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6803725" ], "products": [ "species_6803745", "species_6803778" ], "modifiers": [ [ "species_10333986", "catalyst" ] ], "additional_components": [ "CHEBI:71466", "CHEBI:2700", "CHEBI:85299", "CHEBI:85263", "CHEBI:71464", "CHEBI:85262", "species_3632881", "CHEBI:30805", "CHEBI:9254", "CHEBI:28875", "CHEBI:16196", "species_140356", "Q6DJ82", "ENSXETT00000057513" ] }, "reaction_10320187": { "compartment": "compartment_917757", "id": "reaction_10320187", "reactome": "R-XTR-888577", "name": "Synthesis of GABA by GAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10320184", "catalyst" ] ], "additional_components": [ "F6YRI6", "ENSXETT00000012900" ] }, "reaction_10320192": { "compartment": "compartment_70101", "id": "reaction_10320192", "reactome": "R-XTR-888592", "name": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352011" ], "products": [ "species_428571" ], "modifiers": [ [ "species_10320189", "catalyst" ] ], "additional_components": [ "ENSXETT00000054324" ] }, "reaction_10316559": { "compartment": "compartment_876", "id": "reaction_10316559", "reactome": "R-XTR-212642", "name": "L-Glutamine transport into neurons", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_212615", "species_74113" ], "products": [ "species_83910", "species_29472" ], "modifiers": [ [ "species_10316556", "catalyst" ] ], "additional_components": [ "ENSXETG00000014662" ] }, "reaction_10316154": { "compartment": "compartment_70101", "id": "reaction_10316154", "reactome": "R-XTR-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_10316149" ], "products": [ "species_10316151" ], "modifiers": [ [ "species_10316149", "catalyst" ] ], "additional_components": [ "Q28H43", "ENSXETT00000090296", "Q05B21", "ENSXETT00000082042", "A0A6I8Q031", "ENSXETG00000008255", "Q28H43", "ENSXETT00000090296", "Q05B21", "ENSXETT00000082042", "species_210382", "A0A6I8Q031", "ENSXETG00000008255", "Q28H43", "ENSXETT00000090296", "Q05B21", "ENSXETT00000082042", "A0A6I8Q031", "ENSXETG00000008255" ] }, "reaction_10316115": { "compartment": "compartment_984", "id": "reaction_10316115", "reactome": "R-XTR-210404", "name": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_210382", "species_29804", "species_74113" ], "products": [ "species_74126", "species_29404", "species_70106", "species_83910" ], "modifiers": [ [ "species_10316108", "catalyst" ], [ "species_10316113", "inhibitor" ] ], "additional_components": [ "ENSXETG00000011685", "ENSXETT00000102749" ] }, "reaction_10316133": { "compartment": "compartment_984", "id": "reaction_10316133", "reactome": "R-XTR-210420", "name": "Ca2+ influx through voltage gated Ca2+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10316130", "catalyst" ], [ "species_74126", "inhibitor" ] ], "additional_components": [ "A0A6I8PYQ9", "ENSXETG00000021694", "A0A6I8SXZ7", "ENSXETG00000005585" ] }, "reaction_10337901": { "compartment": "compartment_876", "id": "reaction_10337901", "reactome": "R-XTR-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9634838", "species_10316781" ], "products": [ "species_10316784" ], "modifiers": [], "additional_components": [ "A0A6I8Q0V4", "ENSXETG00000030902", "A0A5G3JDL4", "ENSXETT00000103127", "A0A6I8Q0V4", "ENSXETG00000030902", "A0A5G3JDL4", "ENSXETT00000103127" ] }, "reaction_10317200": { "compartment": "compartment_5460", "id": "reaction_10317200", "reactome": "R-XTR-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_380598" ], "products": [ "species_113529", "species_380593", "species_29362" ], "modifiers": [ [ "species_10311857", "catalyst" ] ], "additional_components": [ "A0A6I8RHR6", "ENSXETG00000020930" ] }, "reaction_10317171": { "compartment": "compartment_70101", "id": "reaction_10317171", "reactome": "R-XTR-379464", "name": "COMT transfers Met to DOPAC to form HVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9677997", "species_71284" ], "products": [ "species_9677992", "species_174369" ], "modifiers": [ [ "species_10317160", "catalyst" ] ], "additional_components": [ "ENSXETT00000064849" ] }, "reaction_10317165": { "compartment": "compartment_70101", "id": "reaction_10317165", "reactome": "R-XTR-379387", "name": "COMT transfers Met to DA to form 3MT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_159362" ], "products": [ "species_8954997", "species_71285" ], "modifiers": [ [ "species_10317160", "catalyst" ], [ "species_10317163", "inhibitor" ] ], "additional_components": [ "ENSXETT00000064849", "A9UMU1", "ENSXETT00000064849" ] }, "reaction_10336969": { "compartment": "compartment_70101", "id": "reaction_10336969", "reactome": "R-XTR-8955010", "name": "LRTOMT transfers Met to DA, forming 3MT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_159362" ], "products": [ "species_8954997", "species_71285" ], "modifiers": [ [ "species_10336966", "catalyst" ] ], "additional_components": [ "ENSXETG00000039768" ] }, "reaction_10338104": { "compartment": "compartment_876", "id": "reaction_10338104", "reactome": "R-XTR-9679775", "name": "COMT binds COMT Inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317160", "species_9679778" ], "products": [ "species_10317163" ], "modifiers": [], "additional_components": [ "ENSXETT00000064849", "A9UMU1", "ENSXETT00000064849" ] }, "reaction_10316786": { "compartment": "compartment_984", "id": "reaction_10316786", "reactome": "R-XTR-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10316781", "catalyst" ], [ "species_10316784", "inhibitor" ] ], "additional_components": [ "A0A6I8Q0V4", "ENSXETG00000030902", "A0A5G3JDL4", "ENSXETT00000103127", "A0A6I8Q0V4", "ENSXETG00000030902", "A0A5G3JDL4", "ENSXETT00000103127" ] }, "reaction_10316552": { "compartment": "compartment_984", "id": "reaction_10316552", "reactome": "R-XTR-212614", "name": "Glutamine transport from astrocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472" ], "products": [ "species_212615" ], "modifiers": [ [ "species_10316549", "catalyst" ] ], "additional_components": [ "ENSXETG00000041195" ] }, "reaction_10311522": { "compartment": "compartment_70101", "id": "reaction_10311522", "reactome": "R-XTR-70606", "name": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113592", "species_31633" ], "products": [ "species_29372", "species_29370", "species_29472" ], "modifiers": [ [ "species_10311519", "catalyst" ] ], "additional_components": [ "F6VAG8", "ENSXETT00000027374" ] }, "reaction_10338094": { "compartment": "compartment_70101", "id": "reaction_10338094", "reactome": "R-XTR-9679029", "name": "C-ter TLR7 dimer binds HCQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338090", "species_9678628" ], "products": [ "species_10338092" ], "modifiers": [], "additional_components": [ "F7EDI8", "ENSXETT00000013094", "F7EDI8", "ENSXETT00000013094" ] }, "reaction_10313351": { "compartment": "compartment_70101", "id": "reaction_10313351", "reactome": "R-XTR-168166", "name": "NFkB complex is transported from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313343" ], "products": [ "species_10313349" ], "modifiers": [], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173" ] }, "reaction_10312161": { "compartment": "compartment_7660", "id": "reaction_10312161", "reactome": "R-XTR-75998", "name": "Formation of RAD52 heptameric ring structure complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312157" ], "products": [ "species_10312159" ], "modifiers": [], "additional_components": [ "ENSXETG00000009413", "A0A6I8RDE5", "ENSXETG00000009413" ] }, "reaction_10337038": { "compartment": "compartment_70101", "id": "reaction_10337038", "reactome": "R-XTR-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317378", "species_10312717" ], "products": [ "species_10317376", "species_10317380" ], "modifiers": [], "additional_components": [ "A0A6I8T271", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10330050": { "compartment": "compartment_70101", "id": "reaction_10330050", "reactome": "R-XTR-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10317380" ], "products": [ "species_29370", "species_10329598", "species_10312717" ], "modifiers": [ [ "species_10317380", "catalyst" ] ], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8T271", "ENSXETG00000011808", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10314369": { "compartment": "compartment_947587", "id": "reaction_10314369", "reactome": "R-XTR-198266", "name": "PI3K produces PIP3 and other phosphatidyl inositides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10314366", "catalyst" ] ], "additional_components": [ "A0A6I8RAF1", "ENSXETG00000039550", "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252" ] }, "reaction_10337673": { "compartment": "compartment_876", "id": "reaction_10337673", "reactome": "R-XTR-9034714", "name": "NTRK3 dimers trans-autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10337661" ], "products": [ "species_10337670", "species_29370" ], "modifiers": [ [ "species_10337661", "catalyst" ] ], "additional_components": [ "F6VUP1", "ENSXETT00000036251", "A0A6I8T1S6", "ENSXETG00000033787", "F6VUP1", "ENSXETT00000036251", "A0A6I8T1S6", "ENSXETG00000033787", "F6VUP1", "ENSXETT00000036251", "A0A6I8T1S6", "ENSXETG00000033787" ] }, "reaction_10334500": { "compartment": "compartment_12045", "id": "reaction_10334500", "reactome": "R-XTR-6807055", "name": "DHCR7 reduces 7-dehydroCHOL to CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6807057", "species_29364" ], "products": [ "species_193384", "species_29366" ], "modifiers": [ [ "species_10314334", "catalyst" ] ], "additional_components": [ "ENSXETG00000008945" ] }, "reaction_10334502": { "compartment": "compartment_12045", "id": "reaction_10334502", "reactome": "R-XTR-6807064", "name": "DHCR24 reduces ZYMOL to ZYMSTNL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194691" ], "products": [ "species_6807048", "species_29366" ], "modifiers": [ [ "species_10314341", "catalyst" ] ], "additional_components": [ "ENSXETG00000020010" ] }, "reaction_10334498": { "compartment": "compartment_12045", "id": "reaction_10334498", "reactome": "R-XTR-6807053", "name": "SC5D desaturates LTHSOL to 7-dehydroCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6807054", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_6807057" ], "modifiers": [ [ "species_10314319", "catalyst" ] ], "additional_components": [ "ENSXETG00000040073" ] }, "reaction_10332459": { "compartment": "compartment_7660", "id": "reaction_10332459", "reactome": "R-XTR-6797090", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10332455", "species_10312628" ], "products": [ "species_10332457" ], "modifiers": [], "additional_components": [ "ENSXETG00000023695", "ENSXETT00000049621", "F7CLE9", "ENSXETT00000049621", "B5DE93", "ENSXETG00000023695" ] }, "reaction_10332465": { "compartment": "compartment_7660", "id": "reaction_10332465", "reactome": "R-XTR-6797100", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312628", "species_10332461" ], "products": [ "species_10332463" ], "modifiers": [], "additional_components": [ "ENSXETT00000049621", "ENSXETG00000023695", "B5DE93", "ENSXETG00000023695", "F7CLE9", "ENSXETT00000049621" ] }, "reaction_10314021": { "compartment": "compartment_7660", "id": "reaction_10314021", "reactome": "R-XTR-187934", "name": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313994", "species_10313486" ], "products": [ "species_10314013" ], "modifiers": [ [ "species_10313994", "catalyst" ] ], "additional_components": [ "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130", "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125", "ENSXETG00000038125" ] }, "reaction_10330057": { "compartment": "compartment_70101", "id": "reaction_10330057", "reactome": "R-XTR-5628905", "name": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30533" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10330054", "catalyst" ] ], "additional_components": [ "ENSXETG00000005971" ] }, "reaction_10330082": { "compartment": "compartment_70101", "id": "reaction_10330082", "reactome": "R-XTR-5632738", "name": "DDIT4 binds 14-3-3 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312804", "species_10330078" ], "products": [ "species_10330080" ], "modifiers": [], "additional_components": [ "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830", "ENSXETT00000083124", "Q6P4J6", "ENSXETT00000083124", "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830" ] }, "reaction_10333927": { "compartment": "compartment_74700", "id": "reaction_10333927", "reactome": "R-XTR-6801195", "name": "STEAP3 binds BNIP3L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333923", "species_10320592" ], "products": [ "species_10333925" ], "modifiers": [], "additional_components": [ "ENSXETT00000022422", "ENSXETT00000016208", "F6YGT5", "ENSXETT00000016208", "F7AAW4", "ENSXETT00000022422" ] }, "reaction_10333915": { "compartment": "compartment_70101", "id": "reaction_10333915", "reactome": "R-XTR-6800793", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333911" ], "products": [ "species_10333913" ], "modifiers": [], "additional_components": [ "ENSXETG00000033984", "ENSXETG00000033984" ] }, "reaction_10320843": { "compartment": "compartment_70101", "id": "reaction_10320843", "reactome": "R-XTR-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_29372", "species_200736" ], "modifiers": [ [ "species_10320840", "catalyst" ] ], "additional_components": [ "species_109496", "A0A6I8R2I0", "ENSXETG00000041151" ] }, "reaction_10335757": { "compartment": "compartment_876", "id": "reaction_10335757", "reactome": "R-XTR-8866269", "name": "ARRB bind GPCRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335751", "species_10335753" ], "products": [ "species_10335755" ], "modifiers": [], "additional_components": [ "F6SUX3", "ENSXETT00000050169", "F6SKI7", "ENSXETT00000021189", "F6SUX3", "ENSXETT00000050169", "F6SKI7", "ENSXETT00000021189" ] }, "reaction_10338108": { "compartment": "compartment_70101", "id": "reaction_10338108", "reactome": "R-XTR-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9648300", "species_10335334" ], "products": [ "species_10335769" ], "modifiers": [], "additional_components": [ "A0A6I8RNH9", "ENSXETG00000013480", "A0A6I8PJR6", "ENSXETG00000009033", "Q6P856", "ENSXETG00000017276", "A0A6I8RNH9", "ENSXETG00000013480", "A0A6I8PJR6", "ENSXETG00000009033", "Q6P856", "ENSXETG00000017276" ] }, "reaction_10335647": { "compartment": "compartment_876", "id": "reaction_10335647", "reactome": "R-XTR-8863463", "name": "STON2 binds SYT proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335633", "species_10335643" ], "products": [ "species_10335645" ], "modifiers": [], "additional_components": [ "A0A6I8PYV5", "ENSXETG00000034334", "A0A6I8SQ61", "ENSXETG00000038939", "A0A6I8SQ61", "ENSXETG00000038939", "A0A6I8PYV5", "ENSXETG00000034334" ] }, "reaction_10335771": { "compartment": "compartment_876", "id": "reaction_10335771", "reactome": "R-XTR-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335334", "species_10335765" ], "products": [ "species_10335767" ], "modifiers": [ [ "species_10335769", "inhibitor" ] ], "additional_components": [ "A0A6I8RNH9", "ENSXETG00000013480", "A0A6I8PJR6", "ENSXETG00000009033", "Q6P856", "ENSXETG00000017276", "F7BD23", "ENSXETT00000017485", "A0A6I8QYZ2", "ENSXETG00000039705", "A0A6I8QZE2", "ENSXETG00000040690", "species_912516", "Q501K5", "ENSXETG00000011814", "A0A6I8QXB4", "ENSXETG00000021138", "F7BD23", "ENSXETT00000017485", "A0A6I8QYZ2", "ENSXETG00000039705", "A0A6I8QZE2", "ENSXETG00000040690", "species_912516", "Q501K5", "ENSXETG00000011814", "A0A6I8QXB4", "ENSXETG00000021138", "A0A6I8RNH9", "ENSXETG00000013480", "A0A6I8PJR6", "ENSXETG00000009033", "Q6P856", "ENSXETG00000017276", "A0A6I8RNH9", "ENSXETG00000013480", "A0A6I8PJR6", "ENSXETG00000009033", "Q6P856", "ENSXETG00000017276" ] }, "reaction_10335824": { "compartment": "compartment_876", "id": "reaction_10335824", "reactome": "R-XTR-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335810", "species_10335820" ], "products": [ "species_10335822" ], "modifiers": [], "additional_components": [ "ENSXETG00000008255", "A0A6I8Q6S5", "ENSXETG00000032563", "A0A6I8Q6S5", "ENSXETG00000032563", "A0A6I8Q031", "ENSXETG00000008255" ] }, "reaction_10335841": { "compartment": "compartment_876", "id": "reaction_10335841", "reactome": "R-XTR-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10323969", "catalyst" ] ], "additional_components": [ "ENSXETT00000042073" ] }, "reaction_10327264": { "compartment": "compartment_70101", "id": "reaction_10327264", "reactome": "R-XTR-3134804", "name": "STING ubiquitination by TRIM32 or TRIM56", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324513", "species_10312116" ], "products": [ "species_10327258", "species_10324511" ], "modifiers": [ [ "species_10324513", "catalyst" ] ], "additional_components": [ "A0A6I8SBS8", "ENSXETG00000039978", "A8E5V9", "ENSXETG00000016088", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "ENSXETG00000016088", "ENSXETG00000039978", "A0A6I8SBS8", "ENSXETG00000039978", "A8E5V9", "ENSXETG00000016088" ] }, "reaction_10324515": { "compartment": "compartment_70101", "id": "reaction_10324515", "reactome": "R-XTR-1964496", "name": "STING binds TRIM32 or TRIM56 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324507", "species_10324511" ], "products": [ "species_10324513" ], "modifiers": [], "additional_components": [ "ENSXETG00000016088", "ENSXETG00000039978", "A0A6I8SBS8", "ENSXETG00000039978", "A8E5V9", "ENSXETG00000016088" ] }, "reaction_10316740": { "compartment": "compartment_876", "id": "reaction_10316740", "reactome": "R-XTR-352108", "name": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352091", "species_74113" ], "products": [ "species_352088", "species_83910" ], "modifiers": [ [ "species_10316556", "catalyst" ] ], "additional_components": [ "species_29432", "species_29472", "species_379717", "CHEBI:57926", "species_200736", "CHEBI:58048", "species_159549", "species_29588", "species_174390", "species_29472", "species_159549", "species_379717", "species_200736", "CHEBI:57926", "species_29588", "species_174390", "species_29432", "CHEBI:58048", "ENSXETG00000014662" ] }, "reaction_10316756": { "compartment": "compartment_876", "id": "reaction_10316756", "reactome": "R-XTR-352232", "name": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352229" ], "products": [ "species_352227" ], "modifiers": [ [ "species_10316753", "catalyst" ] ], "additional_components": [ "species_29500", "CHEBI:58045", "species_29612", "species_29588", "species_174390", "CHEBI:58315", "species_351993", "CHEBI:57762", "CHEBI:58315", "species_29588", "species_174390", "CHEBI:58045", "CHEBI:57762", "species_29612", "species_29500", "species_351993", "B5DDZ9", "ENSXETT00000061667", "F6YKM8", "ENSXETT00000042158" ] }, "reaction_10316743": { "compartment": "compartment_876", "id": "reaction_10316743", "reactome": "R-XTR-352119", "name": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352123", "species_74113" ], "products": [ "species_352105", "species_83910" ], "modifiers": [ [ "species_10316549", "catalyst" ] ], "additional_components": [ "species_29432", "species_29472", "species_200736", "CHEBI:58048", "species_174390", "species_29472", "species_200736", "species_174390", "species_29432", "CHEBI:58048", "ENSXETG00000041195" ] }, "reaction_10317169": { "compartment": "compartment_876", "id": "reaction_10317169", "reactome": "R-XTR-379426", "name": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_351964", "species_74113" ], "products": [ "species_351977", "species_83910", "species_29588" ], "modifiers": [ [ "species_10317013", "catalyst" ] ], "additional_components": [ "F6YKM8", "ENSXETT00000042158", "Q28I80", "ENSXETT00000014625" ] }, "reaction_10316738": { "compartment": "compartment_876", "id": "reaction_10316738", "reactome": "R-XTR-352107", "name": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352101" ], "products": [ "species_352114" ], "modifiers": [ [ "species_10316735", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "species_29588", "species_174390", "species_351993", "CHEBI:57762", "species_29588", "species_174390", "CHEBI:58045", "CHEBI:57762", "species_351993", "ENSXETG00000022279" ] }, "reaction_10317920": { "compartment": "compartment_876", "id": "reaction_10317920", "reactome": "R-XTR-425678", "name": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_74016", "species_74113" ], "products": [ "species_74126", "species_83910", "species_74112" ], "modifiers": [ [ "species_10317917", "catalyst" ] ], "additional_components": [ "ENSXETG00000010290" ] }, "reaction_10335224": { "compartment": "compartment_70101", "id": "reaction_10335224", "reactome": "R-XTR-8855062", "name": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162252", "species_71284" ], "products": [ "species_2162265", "species_71285" ], "modifiers": [ [ "species_10335221", "catalyst" ] ], "additional_components": [ "ENSXETG00000026858" ] }, "reaction_10317940": { "compartment": "compartment_876", "id": "reaction_10317940", "reactome": "R-XTR-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10317937", "catalyst" ] ], "additional_components": [ "A0A6I8PNM9", "ENSXETG00000033166", "A0A6I8S3I9", "ENSXETG00000040616" ] }, "reaction_10317927": { "compartment": "compartment_172574", "id": "reaction_10317927", "reactome": "R-XTR-425965", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425999", "species_83910" ], "products": [ "species_425977", "species_70106" ], "modifiers": [ [ "species_10317924", "catalyst" ] ], "additional_components": [ "ENSXETT00000029654" ] }, "reaction_10318058": { "compartment": "compartment_876", "id": "reaction_10318058", "reactome": "R-XTR-428015", "name": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428027", "species_29804", "species_74113" ], "products": [ "species_74126", "species_427997", "species_70106", "species_83910" ], "modifiers": [ [ "species_10316108", "catalyst" ] ], "additional_components": [ "species_29448", "species_6810061", "species_210382", "species_29448", "species_6810061", "species_210382", "ENSXETG00000011685" ] }, "reaction_10318141": { "compartment": "compartment_876", "id": "reaction_10318141", "reactome": "R-XTR-429749", "name": "SLC5A8 transports monocarboxylates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429739", "species_74113" ], "products": [ "species_83910", "species_429748" ], "modifiers": [ [ "species_10318138", "catalyst" ] ], "additional_components": [ "species_29398", "species_373863", "CHEBI:32544", "species_76179", "species_29416", "CHEBI:30768", "species_76179", "species_29398", "species_29416", "species_373863", "CHEBI:30768", "CHEBI:15940", "ENSXETG00000031274" ] }, "reaction_10318063": { "compartment": "compartment_201753", "id": "reaction_10318063", "reactome": "R-XTR-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_428548" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10318060", "catalyst" ] ], "additional_components": [ "ENSXETT00000082042" ] }, "reaction_10318144": { "compartment": "compartment_876", "id": "reaction_10318144", "reactome": "R-XTR-429767", "name": "Passive I- efflux mediated by SMCT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10318138", "catalyst" ] ], "additional_components": [ "ENSXETG00000031274" ] }, "reaction_10318084": { "compartment": "compartment_201753", "id": "reaction_10318084", "reactome": "R-XTR-428625", "name": "Vesicular inhibitory amino acid transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428592", "species_428548" ], "products": [ "species_428632", "species_70106" ], "modifiers": [ [ "species_10318081", "catalyst" ] ], "additional_components": [ "species_159549", "species_428571", "species_428571", "species_159549", "ENSXETT00000054324" ] }, "reaction_10318014": { "compartment": "compartment_876", "id": "reaction_10318014", "reactome": "R-XTR-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10318011", "catalyst" ] ], "additional_components": [ "ENSXETG00000005947" ] }, "reaction_10335952": { "compartment": "compartment_70101", "id": "reaction_10335952", "reactome": "R-XTR-8876312", "name": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8876310", "species_74113" ], "products": [ "species_83910", "species_8876304" ], "modifiers": [ [ "species_10335949", "catalyst" ] ], "additional_components": [ "species_29398", "species_373863", "CHEBI:32544", "species_29398", "species_373863", "CHEBI:15940", "ENSXETG00000025601" ] }, "reaction_10318034": { "compartment": "compartment_876", "id": "reaction_10318034", "reactome": "R-XTR-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_111627" ], "products": [ "species_425425", "species_352022" ], "modifiers": [ [ "species_10318031", "catalyst" ] ], "additional_components": [ "ENSXETG00000016188" ] }, "reaction_10318027": { "compartment": "compartment_876", "id": "reaction_10318027", "reactome": "R-XTR-427605", "name": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10318024", "catalyst" ] ], "additional_components": [ "Q28E01", "ENSXETG00000009532", "Q5BL44", "ENSXETT00000041138" ] }, "reaction_10312261": { "compartment": "compartment_7660", "id": "reaction_10312261", "reactome": "R-XTR-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312257", "species_10312253" ], "products": [ "species_10312259" ], "modifiers": [], "additional_components": [ "ENSXETG00000010179", "ENSXETT00000041997", "Q6DES0", "ENSXETT00000041997", "Q6DIE2", "ENSXETG00000010179" ] }, "reaction_10318606": { "compartment": "compartment_70101", "id": "reaction_10318606", "reactome": "R-XTR-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450523", "species_10318588" ], "products": [ "species_10318590" ], "modifiers": [], "additional_components": [ "ENSXETG00000030723", "A0A6I8SGT0", "ENSXETG00000030723" ] }, "reaction_10318952": { "compartment": "compartment_70101", "id": "reaction_10318952", "reactome": "R-XTR-482788", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312800", "species_10318596" ], "products": [ "species_10318950" ], "modifiers": [], "additional_components": [ "ENSXETG00000022830", "A0A6I8SGT0", "ENSXETG00000030723", "A0A6I8SGT0", "ENSXETG00000030723", "Q5XGC8", "ENSXETG00000022830" ] }, "reaction_10318586": { "compartment": "compartment_70101", "id": "reaction_10318586", "reactome": "R-XTR-450406", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312800", "species_10318582" ], "products": [ "species_10318584" ], "modifiers": [], "additional_components": [ "ENSXETG00000022830", "A0A6I8SGT0", "ENSXETG00000030723", "A0A6I8SGT0", "ENSXETG00000030723", "Q5XGC8", "ENSXETG00000022830" ] }, "reaction_10318604": { "compartment": "compartment_7660", "id": "reaction_10318604", "reactome": "R-XTR-450494", "name": "HuR binds mRNAs in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318600", "species_450613" ], "products": [ "species_10318602" ], "modifiers": [], "additional_components": [ "ENSXETG00000008752", "Q6GLB5", "ENSXETG00000008752" ] }, "reaction_10319007": { "compartment": "compartment_7660", "id": "reaction_10319007", "reactome": "R-XTR-517705", "name": "p-S318,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318610", "species_517622" ], "products": [ "species_10319005" ], "modifiers": [], "additional_components": [ "ENSXETG00000008752", "Q6GLB5", "ENSXETG00000008752" ] }, "reaction_10319003": { "compartment": "compartment_7660", "id": "reaction_10319003", "reactome": "R-XTR-517674", "name": "p-S158,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450605", "species_10318613" ], "products": [ "species_10319001" ], "modifiers": [], "additional_components": [ "ENSXETG00000008752", "Q6GLB5", "ENSXETG00000008752" ] }, "reaction_10314047": { "compartment": "compartment_984", "id": "reaction_10314047", "reactome": "R-XTR-188979", "name": "Digestion of linear starch (amylose) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189075" ], "products": [ "species_191103", "species_188986" ], "modifiers": [ [ "species_10314044", "catalyst" ] ], "additional_components": [ "species_70113", "ENSXETG00000010847" ] }, "reaction_10314056": { "compartment": "compartment_984", "id": "reaction_10314056", "reactome": "R-XTR-189062", "name": "lactose + H2O => D-glucose + D-galactose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188973", "species_109276" ], "products": [ "species_70115", "species_188995" ], "modifiers": [ [ "species_10314053", "catalyst" ] ], "additional_components": [ "A0A6I8SYH9", "ENSXETG00000025031" ] }, "reaction_10314145": { "compartment": "compartment_984", "id": "reaction_10314145", "reactome": "R-XTR-191114", "name": "Digestion of branched starch (amylopectin) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189071" ], "products": [ "species_191103", "species_188986", "species_189108" ], "modifiers": [ [ "species_10314044", "catalyst" ] ], "additional_components": [ "species_70113", "ENSXETG00000010847" ] }, "reaction_10328964": { "compartment": "compartment_7660", "id": "reaction_10328964", "reactome": "R-XTR-4755536", "name": "PIAS3 SUMOylates RELA with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327222", "species_10328953" ], "products": [ "species_10328962", "species_10327128" ], "modifiers": [ [ "species_10328492", "catalyst" ] ], "additional_components": [ "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8PS73", "ENSXETG00000026173", "ENSXETT00000054232", "ENSXETG00000018642" ] }, "reaction_10334705": { "compartment": "compartment_20699", "id": "reaction_10334705", "reactome": "R-XTR-8848484", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_29356" ], "products": [ "species_6814303", "species_8848483" ], "modifiers": [ [ "species_10318101", "catalyst" ] ], "additional_components": [ "ENSXETT00000066288" ] }, "reaction_10335199": { "compartment": "compartment_17938", "id": "reaction_10335199", "reactome": "R-XTR-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10335194" ], "products": [ "species_29372", "species_10335196" ], "modifiers": [ [ "species_10335194", "catalyst" ] ], "additional_components": [ "species_29438", "F7A377", "ENSXETT00000029250", "F7A377", "ENSXETT00000029250", "species_29420", "species_29438", "F7A377", "ENSXETT00000029250" ] }, "reaction_10335189": { "compartment": "compartment_24339", "id": "reaction_10335189", "reactome": "R-XTR-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10335180" ], "products": [ "species_29372", "species_10335182" ], "modifiers": [ [ "species_10335180", "catalyst" ], [ "species_10335187", "catalyst" ] ], "additional_components": [ "Q6P7Z7", "ENSXETT00000056541", "species_29438", "Q6P7Z7", "ENSXETT00000056541", "species_29420", "Q6P7Z7", "ENSXETT00000056541", "species_29438", "ENSXETT00000043751" ] }, "reaction_10335207": { "compartment": "compartment_17938", "id": "reaction_10335207", "reactome": "R-XTR-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10335194" ], "products": [ "species_29372", "species_10335205" ], "modifiers": [ [ "species_10335194", "catalyst" ] ], "additional_components": [ "species_29438", "F7A377", "ENSXETT00000029250", "species_29420", "F7A377", "ENSXETT00000029250", "species_29438", "F7A377", "ENSXETT00000029250" ] }, "reaction_10335984": { "compartment": "compartment_70101", "id": "reaction_10335984", "reactome": "R-XTR-8876446", "name": "p-ULK1 phosphorylates DENND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335969", "species_113592" ], "products": [ "species_29370", "species_10335973" ], "modifiers": [ [ "species_10335981", "catalyst" ] ], "additional_components": [ "ENSXETT00000054527", "ENSXETT00000054527", "ENSXETG00000002028" ] }, "reaction_10318634": { "compartment": "compartment_70101", "id": "reaction_10318634", "reactome": "R-XTR-451056", "name": "Microtubule-independent trafficking of connexons to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318628" ], "products": [ "species_10318632" ], "modifiers": [], "additional_components": [ "Q28ED4", "ENSXETT00000055228", "Q28ED4", "ENSXETT00000055228" ] }, "reaction_10314143": { "compartment": "compartment_12045", "id": "reaction_10314143", "reactome": "R-XTR-190681", "name": "Connexin oligomerization in endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314138" ], "products": [ "species_10314140" ], "modifiers": [ [ "species_10314138", "catalyst" ] ], "additional_components": [ "ENSXETT00000055497", "Q6NVT8", "ENSXETT00000055497", "ENSXETT00000055497" ] }, "reaction_10335934": { "compartment": "compartment_20699", "id": "reaction_10335934", "reactome": "R-XTR-8874979", "name": "ACBD3 binds GOLGB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335924", "species_10335930" ], "products": [ "species_10335932" ], "modifiers": [], "additional_components": [ "ENSXETT00000048980", "A0A6I8PMP5", "ENSXETG00000033340", "A0A6I8PMP5", "ENSXETG00000033340", "F6WGE2", "ENSXETT00000048980" ] }, "reaction_10326647": { "compartment": "compartment_24337", "id": "reaction_10326647", "reactome": "R-XTR-2247512", "name": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326631" ], "products": [ "species_10326645" ], "modifiers": [], "additional_components": [ "species_426658", "species_33625", "CHEBI:28640", "species_2186967", "species_30495", "CHEBI:37671", "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "species_171142", "species_216762", "CHEBI:60479", "CHEBI:64009", "CHEBI:64294", "A0A6I8RKY6", "ENSXETG00000026768", "CHEBI:24654", "A0A6I8S279", "ENSXETG00000037724", "A0A6I8S279", "ENSXETG00000037724", "CHEBI:64294", "CHEBI:60479", "species_171126", "species_171142", "CHEBI:24654", "A0A6I8RKY6", "ENSXETG00000026768", "CHEBI:64009", "species_163579", "species_216762", "CHEBI:28640", "species_426658", "species_30495", "species_2186967", "CHEBI:37671", "A0A6I8PU04", "ENSXETG00000033423", "species_33625" ] }, "reaction_10318182": { "compartment": "compartment_876", "id": "reaction_10318182", "reactome": "R-XTR-434381", "name": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_400452" ], "products": [ "species_3632881" ], "modifiers": [ [ "species_10318179", "catalyst" ] ], "additional_components": [ "ENSXETG00000037724" ] }, "reaction_10329322": { "compartment": "compartment_13231", "id": "reaction_10329322", "reactome": "R-XTR-5223304", "name": "DAG and Ca+2 bind to PKC and tether it to membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329318", "species_5221124", "species_29496" ], "products": [ "species_10329320" ], "modifiers": [], "additional_components": [ "ENSXETG00000017294", "species_74112", "species_114519", "A8KBH6", "ENSXETG00000017294" ] }, "reaction_10326334": { "compartment": "compartment_7660", "id": "reaction_10326334", "reactome": "R-XTR-2172678", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326327", "species_113671", "species_113685" ], "products": [ "species_29478", "species_10326331", "species_159942", "species_159939" ], "modifiers": [ [ "species_10326327", "catalyst" ] ], "additional_components": [ "species_435347", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8RKR7", "ENSXETG00000035354", "species_435347", "species_435347", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10326658": { "compartment": "compartment_7660", "id": "reaction_10326658", "reactome": "R-XTR-2301205", "name": "SETD8 monomethylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10326331" ], "products": [ "species_77502", "species_10326327" ], "modifiers": [ [ "species_10326655", "catalyst" ] ], "additional_components": [ "A0A6I8RKR7", "ENSXETG00000035354", "species_435347", "species_435347", "A0A6I8RKR7", "ENSXETG00000035354", "ENSXETT00000012803" ] }, "reaction_10326218": { "compartment": "compartment_7660", "id": "reaction_10326218", "reactome": "R-XTR-2168079", "name": "MASTL (GWL) phosphorylates ARPP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10326205" ], "products": [ "species_113582", "species_10326208" ], "modifiers": [ [ "species_10326215", "catalyst" ] ], "additional_components": [ "ENSXETG00000027097", "ENSXETG00000027097", "ENSXETG00000018741" ] }, "reaction_10326837": { "compartment": "compartment_7660", "id": "reaction_10326837", "reactome": "R-XTR-2430535", "name": "MASTL phosphorylates ENSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10326832" ], "products": [ "species_113582", "species_10326835" ], "modifiers": [ [ "species_10326215", "catalyst" ] ], "additional_components": [ "ENSXETT00000056121", "ENSXETT00000056121", "ENSXETG00000018741" ] }, "reaction_10337987": { "compartment": "compartment_70101", "id": "reaction_10337987", "reactome": "R-XTR-9647746", "name": "EML4 trimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337983" ], "products": [ "species_10337985" ], "modifiers": [], "additional_components": [ "ENSXETG00000006002", "Q6DIP5", "ENSXETG00000006002" ] }, "reaction_10313138": { "compartment": "compartment_7660", "id": "reaction_10313138", "reactome": "R-XTR-163010", "name": "Down Regulation of Emi1 through Phosphorylation of Emi1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10313127" ], "products": [ "species_113582", "species_10313130" ], "modifiers": [ [ "species_10313135", "catalyst" ] ], "additional_components": [ "ENSXETG00000018545", "ENSXETG00000018545", "ENSXETT00000022754" ] }, "reaction_10337822": { "compartment": "compartment_70101", "id": "reaction_10337822", "reactome": "R-XTR-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9624879", "species_10337818" ], "products": [ "species_10337820" ], "modifiers": [], "additional_components": [ "Q6GL85", "ENSXETG00000027832", "species_29438", "Q6GL85", "ENSXETG00000027832", "species_29438" ] }, "reaction_10313996": { "compartment": "compartment_13231", "id": "reaction_10313996", "reactome": "R-XTR-187506", "name": "Translocation of p27 to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313992" ], "products": [ "species_10313994" ], "modifiers": [], "additional_components": [ "ENSXETG00000038125", "ENSXETG00000038125" ] }, "reaction_10314011": { "compartment": "compartment_7660", "id": "reaction_10314011", "reactome": "R-XTR-187520", "name": "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314003", "species_29358" ], "products": [ "species_113582", "species_10314008" ], "modifiers": [ [ "species_10314003", "catalyst" ] ], "additional_components": [ "A0A6I8SFF7", "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10313473": { "compartment": "compartment_70101", "id": "reaction_10313473", "reactome": "R-XTR-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311363", "species_10313428" ], "products": [ "species_10313471" ], "modifiers": [], "additional_components": [ "ENSXETT00000046130", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10313488": { "compartment": "compartment_13231", "id": "reaction_10313488", "reactome": "R-XTR-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313471" ], "products": [ "species_10313486" ], "modifiers": [], "additional_components": [ "F6T0J1", "ENSXETT00000046130", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10314032": { "compartment": "compartment_7660", "id": "reaction_10314032", "reactome": "R-XTR-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10311391" ], "products": [ "species_113582", "species_10312634" ], "modifiers": [ [ "species_10314001", "catalyst" ] ], "additional_components": [ "ENSXETG00000031493", "ENSXETG00000031493", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10314018": { "compartment": "compartment_7660", "id": "reaction_10314018", "reactome": "R-XTR-187916", "name": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10314013" ], "products": [ "species_113582", "species_10314015" ], "modifiers": [ [ "species_10314013", "catalyst" ] ], "additional_components": [ "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125" ] }, "reaction_10311361": { "compartment": "compartment_7660", "id": "reaction_10311361", "reactome": "R-XTR-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311355" ], "products": [ "species_10311333", "species_10311353", "species_10311359", "species_10311341" ], "modifiers": [], "additional_components": [ "Q561P5", "ENSXETG00000000253", "Q6GL41", "ENSXETG00000004854", "Q6DIH3", "ENSXETG00000002059", "Q28BS0", "ENSXETG00000021701", "Q6NX31", "ENSXETT00000074596", "Q6P1V8", "ENSXETG00000014891", "ENSXETG00000021701", "ENSXETG00000002059", "Q6GL41", "ENSXETG00000004854", "Q6NX31", "ENSXETT00000074596", "Q6P1V8", "ENSXETG00000014891", "ENSXETG00000000253" ] }, "reaction_10338031": { "compartment": "compartment_70101", "id": "reaction_10338031", "reactome": "R-XTR-9659820", "name": "RB1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338029" ], "products": [ "species_10311367" ], "modifiers": [], "additional_components": [ "ENSXETG00000031493", "ENSXETG00000031493" ] }, "reaction_10322470": { "compartment": "compartment_7660", "id": "reaction_10322470", "reactome": "R-XTR-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322466", "species_10313486" ], "products": [ "species_10322468" ], "modifiers": [], "additional_components": [ "ENSXETT00000008804", "F6T0J1", "ENSXETT00000046130", "F6T0J1", "ENSXETT00000046130", "F6UBS5", "ENSXETT00000008804" ] }, "reaction_10326109": { "compartment": "compartment_12045", "id": "reaction_10326109", "reactome": "R-XTR-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10326106", "catalyst" ] ], "additional_components": [ "A0A6I8SJ30", "ENSXETG00000038590", "A0A6I8PUP3", "ENSXETG00000033706", "F6W5W2", "ENSXETT00000042586", "A4IGV4", "ENSXETT00000061279" ] }, "reaction_10326121": { "compartment": "compartment_12045", "id": "reaction_10326121", "reactome": "R-XTR-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10326118", "catalyst" ] ], "additional_components": [ "A0A6I8SJ30", "ENSXETG00000038590", "F6W5W2", "ENSXETT00000042586", "A4IGV4", "ENSXETT00000061279" ] }, "reaction_10326104": { "compartment": "compartment_12045", "id": "reaction_10326104", "reactome": "R-XTR-2161795", "name": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2161639" ], "modifiers": [ [ "species_10326101", "catalyst" ] ], "additional_components": [ "CHEBI:63995", "CHEBI:63994", "CHEBI:63579", "A0A6I8SJ30", "ENSXETG00000038590", "A4IGV4", "ENSXETT00000061279" ] }, "reaction_10316618": { "compartment": "compartment_70101", "id": "reaction_10316618", "reactome": "R-XTR-264444", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316611", "species_10312116" ], "products": [ "species_10316615" ], "modifiers": [ [ "species_10316611", "catalyst" ] ], "additional_components": [ "ENSXETG00000009192", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8RXS2", "ENSXETG00000009192", "ENSXETG00000009192" ] }, "reaction_10316613": { "compartment": "compartment_13231", "id": "reaction_10316613", "reactome": "R-XTR-264418", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316609" ], "products": [ "species_10316611" ], "modifiers": [], "additional_components": [ "ENSXETG00000009192", "ENSXETG00000009192" ] }, "reaction_10320461": { "compartment": "compartment_17963", "id": "reaction_10320461", "reactome": "R-XTR-914012", "name": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320438" ], "products": [ "species_10320454", "species_205687" ], "modifiers": [ [ "species_10320458", "catalyst" ] ], "additional_components": [ "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "ENSXETG00000032293" ] }, "reaction_10320365": { "compartment": "compartment_17963", "id": "reaction_10320365", "reactome": "R-XTR-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10320292" ], "products": [ "species_10320363", "species_205687" ], "modifiers": [], "additional_components": [ "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522" ] }, "reaction_10320383": { "compartment": "compartment_17963", "id": "reaction_10320383", "reactome": "R-XTR-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320292" ], "products": [ "species_205687", "species_10320381" ], "modifiers": [], "additional_components": [ "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8R3H8", "ENSXETG00000039522" ] }, "reaction_10320479": { "compartment": "compartment_17963", "id": "reaction_10320479", "reactome": "R-XTR-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10320292" ], "products": [ "species_205687", "species_10320477" ], "modifiers": [], "additional_components": [ "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8R3H8", "ENSXETG00000039522" ] }, "reaction_10331400": { "compartment": "compartment_20699", "id": "reaction_10331400", "reactome": "R-XTR-5694487", "name": "A4GNT transfers GlcNAc to core 2 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320454" ], "products": [ "species_10331393", "species_205687" ], "modifiers": [ [ "species_10331397", "catalyst" ] ], "additional_components": [ "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8R3H8", "ENSXETG00000039522", "ENSXETG00000037302" ] }, "reaction_10320347": { "compartment": "compartment_17963", "id": "reaction_10320347", "reactome": "R-XTR-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320292" ], "products": [ "species_205687", "species_10320345" ], "modifiers": [], "additional_components": [ "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8QTA8", "ENSXETG00000018869" ] }, "reaction_10320327": { "compartment": "compartment_20699", "id": "reaction_10320327", "reactome": "R-XTR-913675", "name": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10320276" ], "products": [ "species_10320292", "species_205687" ], "modifiers": [ [ "species_10320324", "catalyst" ] ], "additional_components": [ "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "Q6DJR8", "ENSXETG00000040522", "A0A6I8SNY2", "ENSXETG00000040522", "F6VQB1", "ENSXETT00000045011", "F6R8Z5", "ENSXETT00000046964" ] }, "reaction_10332295": { "compartment": "compartment_20699", "id": "reaction_10332295", "reactome": "R-XTR-6786012", "name": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10320454" ], "products": [ "species_10332290", "species_742343" ], "modifiers": [ [ "species_10332292", "catalyst" ] ], "additional_components": [ "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "ENSXETG00000040380" ] }, "reaction_10320422": { "compartment": "compartment_20699", "id": "reaction_10320422", "reactome": "R-XTR-914010", "name": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320292" ], "products": [ "species_205687", "species_10320399" ], "modifiers": [ [ "species_10320419", "catalyst" ] ], "additional_components": [ "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8SXK5", "ENSXETG00000040687", "Q6P3P5", "ENSXETT00000055015" ] }, "reaction_10320497": { "compartment": "compartment_20699", "id": "reaction_10320497", "reactome": "R-XTR-914018", "name": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320399" ], "products": [ "species_205687", "species_10320495" ], "modifiers": [ [ "species_10320458", "catalyst" ] ], "additional_components": [ "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "ENSXETG00000032293" ] }, "reaction_10316180": { "compartment": "compartment_7660", "id": "reaction_10316180", "reactome": "R-XTR-211178", "name": "Phosphorylated FOXO1A is excluded from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315552" ], "products": [ "species_10316178" ], "modifiers": [], "additional_components": [ "ENSXETT00000101788", "ENSXETT00000101788" ] }, "reaction_10338106": { "compartment": "compartment_70101", "id": "reaction_10338106", "reactome": "R-XTR-9680443", "name": "ROCK1,2 bind ROCKi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9686558", "species_10317786" ], "products": [ "species_10317790" ], "modifiers": [], "additional_components": [ "ENSXETG00000023782", "A0A6I8Q6H0", "ENSXETG00000023782" ] }, "reaction_10317792": { "compartment": "compartment_70101", "id": "reaction_10317792", "reactome": "R-XTR-419049", "name": "ROCK activation by RHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317786", "species_10317689" ], "products": [ "species_10317788" ], "modifiers": [ [ "species_10317790", "inhibitor" ] ], "additional_components": [ "ENSXETG00000023782", "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8Q6H0", "ENSXETG00000023782", "A0A6I8Q6H0", "ENSXETG00000023782" ] }, "reaction_10336907": { "compartment": "compartment_5460", "id": "reaction_10336907", "reactome": "R-XTR-8952903", "name": "ADPRHL2 hydrolyses poly(ADP-ribose)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8952909", "species_113521" ], "products": [ "species_8952909", "species_8952905" ], "modifiers": [ [ "species_10336904", "catalyst" ] ], "additional_components": [ "species_8952905", "species_8952905", "ENSXETG00000004374" ] }, "reaction_10312814": { "compartment": "compartment_70101", "id": "reaction_10312814", "reactome": "R-XTR-139905", "name": "Translocation of activated BAD protein to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312810" ], "products": [ "species_10312812" ], "modifiers": [], "additional_components": [ "ENSXETG00000031875", "ENSXETG00000031875" ] }, "reaction_10312808": { "compartment": "compartment_70101", "id": "reaction_10312808", "reactome": "R-XTR-139899", "name": "Sequestration of BAD protein by 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312790", "species_10312804" ], "products": [ "species_10312806" ], "modifiers": [], "additional_components": [ "ENSXETG00000031875", "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830", "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830", "A0A6I8PXS6", "ENSXETG00000031875" ] }, "reaction_10312632": { "compartment": "compartment_7660", "id": "reaction_10312632", "reactome": "R-XTR-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312624", "species_10312628" ], "products": [ "species_10312630" ], "modifiers": [], "additional_components": [ "ENSXETG00000024742", "ENSXETT00000049621", "F7CLE9", "ENSXETT00000049621", "Q6GLD8", "ENSXETG00000024742" ] }, "reaction_10328189": { "compartment": "compartment_876", "id": "reaction_10328189", "reactome": "R-XTR-3781943", "name": "WLS:WNT complex is internalized for maturation into exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327498" ], "products": [ "species_10328169" ], "modifiers": [], "additional_components": [ "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930", "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930" ] }, "reaction_10327518": { "compartment": "compartment_171062", "id": "reaction_10327518", "reactome": "R-XTR-3247847", "name": "WLS is endocytosed to the early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327484" ], "products": [ "species_10327516" ], "modifiers": [], "additional_components": [ "ENSXETG00000012387", "ENSXETG00000012387" ] }, "reaction_10327512": { "compartment": "compartment_984", "id": "reaction_10327512", "reactome": "R-XTR-3247843", "name": "secretion of WNT ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327498" ], "products": [ "species_10327510", "species_10327484" ], "modifiers": [], "additional_components": [ "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930", "A0A6I8PXW7", "ENSXETG00000031623", "A0A6I8PX82", "ENSXETG00000011173", "A0A6I8QGQ0", "ENSXETG00000039930", "B2GUT4", "ENSXETT00000042046", "A0A6I8R7P2", "ENSXETG00000031217", "ENSXETG00000012387" ] }, "reaction_10328187": { "compartment": "compartment_383505", "id": "reaction_10328187", "reactome": "R-XTR-3781941", "name": "WNTs are secreted in exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328169" ], "products": [ "species_10328185" ], "modifiers": [], "additional_components": [ "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930", "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930" ] }, "reaction_10327482": { "compartment": "compartment_20699", "id": "reaction_10327482", "reactome": "R-XTR-3247840", "name": "WLS binds WNT ligands in the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327472", "species_10327478" ], "products": [ "species_10327480" ], "modifiers": [], "additional_components": [ "A0A6I8QGQ0", "ENSXETG00000039930", "ENSXETG00000012387", "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930" ] }, "reaction_10327514": { "compartment": "compartment_20699", "id": "reaction_10327514", "reactome": "R-XTR-3247844", "name": "WNT ligands traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327480" ], "products": [ "species_10327498" ], "modifiers": [], "additional_components": [ "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930", "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930" ] }, "reaction_10327474": { "compartment": "compartment_17963", "id": "reaction_10327474", "reactome": "R-XTR-3247837", "name": "WNT ligands traffic to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327460" ], "products": [ "species_10327472" ], "modifiers": [], "additional_components": [ "A0A6I8QGQ0", "ENSXETG00000039930", "A0A6I8QGQ0", "ENSXETG00000039930" ] }, "reaction_10312702": { "compartment": "compartment_17906", "id": "reaction_10312702", "reactome": "R-XTR-114284", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312698" ], "products": [ "species_10312660" ], "modifiers": [ [ "species_10312700", "catalyst" ] ], "additional_components": [ "Q6PBF4", "ENSXETT00000049267", "Q640U4", "ENSXETT00000018532", "Q640U4", "ENSXETT00000018532", "Q6PBF4", "ENSXETT00000049267", "A0A6I8QFQ5", "ENSXETG00000038338", "F6TEC3", "ENSXETT00000031936" ] }, "reaction_10337835": { "compartment": "compartment_70101", "id": "reaction_10337835", "reactome": "R-XTR-9627106", "name": "SMAC (DIABLO) forms dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312709" ], "products": [ "species_10337828" ], "modifiers": [], "additional_components": [ "ENSXETT00000008194", "Q0IJ31", "ENSXETT00000008194" ] }, "reaction_10312711": { "compartment": "compartment_17906", "id": "reaction_10312711", "reactome": "R-XTR-114307", "name": "Release of SMAC (DIABLO) from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312707" ], "products": [ "species_10312709" ], "modifiers": [ [ "species_10312700", "catalyst" ] ], "additional_components": [ "ENSXETT00000008194", "ENSXETT00000008194", "A0A6I8QFQ5", "ENSXETG00000038338", "F6TEC3", "ENSXETT00000031936" ] }, "reaction_10334049": { "compartment": "compartment_70101", "id": "reaction_10334049", "reactome": "R-XTR-6805507", "name": "APAF1 binds AVEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312666", "species_10334045" ], "products": [ "species_10334047" ], "modifiers": [], "additional_components": [ "A0A6I8RCL3", "ENSXETG00000006695", "species_29370", "ENSXETG00000017866", "A0A6I8PLL4", "ENSXETG00000017866", "A0A6I8RCL3", "ENSXETG00000006695", "species_29370" ] }, "reaction_10312672": { "compartment": "compartment_70101", "id": "reaction_10312672", "reactome": "R-XTR-114254", "name": "CYCS binds to APAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10312660", "species_10312666" ], "products": [ "species_29370", "species_10312670" ], "modifiers": [], "additional_components": [ "Q640U4", "ENSXETT00000018532", "Q6PBF4", "ENSXETT00000049267", "A0A6I8RCL3", "ENSXETG00000006695", "species_29370", "A0A6I8RCL3", "ENSXETG00000006695", "species_113593", "Q640U4", "ENSXETT00000018532", "Q6PBF4", "ENSXETT00000049267" ] }, "reaction_10337832": { "compartment": "compartment_70101", "id": "reaction_10337832", "reactome": "R-XTR-9627104", "name": "XIAP binds CASP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312650", "species_10329609" ], "products": [ "species_10337826" ], "modifiers": [ [ "species_10337830", "inhibitor" ] ], "additional_components": [ "A0A6I8PZK4", "ENSXETG00000030678", "ENSXETT00000035327", "Q5BKL8", "ENSXETT00000035327", "A0A6I8PZK4", "ENSXETG00000030678", "Q0IJ31", "ENSXETT00000008194", "Q5BKL8", "ENSXETT00000035327", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10337839": { "compartment": "compartment_70101", "id": "reaction_10337839", "reactome": "R-XTR-9627350", "name": "SMAC (DIABLO) binds XIAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337828", "species_10329609" ], "products": [ "species_10337837" ], "modifiers": [], "additional_components": [ "Q0IJ31", "ENSXETT00000008194", "ENSXETT00000035327", "Q5BKL8", "ENSXETT00000035327", "Q0IJ31", "ENSXETT00000008194" ] }, "reaction_10328555": { "compartment": "compartment_12045", "id": "reaction_10328555", "reactome": "R-XTR-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419981", "species_29364" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10328552", "catalyst" ] ], "additional_components": [ "ENSXETG00000021063" ] }, "reaction_10336283": { "compartment": "compartment_70101", "id": "reaction_10336283", "reactome": "R-XTR-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869353", "species_113592" ], "products": [ "species_1132084", "species_29360" ], "modifiers": [ [ "species_10314359", "catalyst" ] ], "additional_components": [ "species_109496", "A4IH61", "ENSXETT00000027403" ] }, "reaction_10314362": { "compartment": "compartment_70101", "id": "reaction_10314362", "reactome": "R-XTR-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_1132084" ], "modifiers": [ [ "species_10314359", "catalyst" ] ], "additional_components": [ "species_109496", "A4IH61", "ENSXETT00000027403" ] }, "reaction_10335877": { "compartment": "compartment_70101", "id": "reaction_10335877", "reactome": "R-XTR-8869633", "name": "NMRK1 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_8869353", "species_70106", "species_29370" ], "modifiers": [ [ "species_10335871", "catalyst" ] ], "additional_components": [ "ENSXETG00000031505" ] }, "reaction_10329621": { "compartment": "compartment_70101", "id": "reaction_10329621", "reactome": "R-XTR-5359451", "name": "NNMT transfers CH3 from SAM to NAM to form MNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197277", "species_71284" ], "products": [ "species_549282", "species_71285" ], "modifiers": [ [ "species_10313553", "catalyst" ] ], "additional_components": [ "ENSXETG00000028049" ] }, "reaction_10336214": { "compartment": "compartment_70101", "id": "reaction_10336214", "reactome": "R-XTR-8938073", "name": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938276", "species_29360" ], "products": [ "species_197277", "species_8938282" ], "modifiers": [ [ "species_10336211", "catalyst" ] ], "additional_components": [ "A0A1B8XUU3", "ENSXETT00000078735", "F6YMQ2", "ENSXETT00000038413" ] }, "reaction_10334496": { "compartment": "compartment_5460", "id": "reaction_10334496", "reactome": "R-XTR-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10334493", "catalyst" ] ], "additional_components": [ "A0A5S6NBZ0", "ENSXETG00000020391" ] }, "reaction_10335874": { "compartment": "compartment_70101", "id": "reaction_10335874", "reactome": "R-XTR-8869606", "name": "NMRK1 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10335871", "catalyst" ] ], "additional_components": [ "ENSXETG00000031505" ] }, "reaction_10336978": { "compartment": "compartment_5460", "id": "reaction_10336978", "reactome": "R-XTR-8955030", "name": "NADK2 dimer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113526" ], "products": [ "species_113581", "species_113563", "species_113529" ], "modifiers": [ [ "species_10336975", "catalyst" ] ], "additional_components": [ "Q08CZ6", "ENSXETT00000010405" ] }, "reaction_10314353": { "compartment": "compartment_70101", "id": "reaction_10314353", "reactome": "R-XTR-196955", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29386" ], "products": [ "species_73524", "species_76577" ], "modifiers": [ [ "species_10314350", "catalyst" ] ], "additional_components": [ "A0A6I8RYX5", "ENSXETG00000030043" ] }, "reaction_10315543": { "compartment": "compartment_70616", "id": "reaction_10315543", "reactome": "R-XTR-199216", "name": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194" ], "products": [ "species_29374" ], "modifiers": [ [ "species_10315540", "catalyst" ] ], "additional_components": [ "ENSXETG00000030903" ] }, "reaction_10327160": { "compartment": "compartment_70101", "id": "reaction_10327160", "reactome": "R-XTR-2993802", "name": "HLCS biotinylates PC:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_199207", "species_10327148" ], "products": [ "species_111294", "species_10327153", "species_76577" ], "modifiers": [ [ "species_10327157", "catalyst" ] ], "additional_components": [ "A0A6I8QW74", "ENSXETG00000008415", "CHEBI:29035", "A0A6I8QW74", "ENSXETG00000008415", "CHEBI:29035", "ENSXETG00000013028" ] }, "reaction_10327703": { "compartment": "compartment_70101", "id": "reaction_10327703", "reactome": "R-XTR-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327153" ], "products": [ "species_10327240" ], "modifiers": [], "additional_components": [ "A0A6I8QW74", "ENSXETG00000008415", "CHEBI:29035", "CHEBI:29035", "A0A6I8QW74", "ENSXETG00000008415" ] }, "reaction_10331341": { "compartment": "compartment_70616", "id": "reaction_10331341", "reactome": "R-XTR-5694137", "name": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_5693984", "species_113521" ], "products": [ "species_200671", "species_379732" ], "modifiers": [ [ "species_10331338", "catalyst" ] ], "additional_components": [ "A0A6I8RGC7", "ENSXETG00000017162" ] }, "reaction_10315636": { "compartment": "compartment_70101", "id": "reaction_10315636", "reactome": "R-XTR-200735", "name": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_197969" ], "products": [ "species_29424", "species_200739" ], "modifiers": [ [ "species_10311706", "catalyst" ] ], "additional_components": [ "A0A6I8QRM0", "ENSXETG00000005754" ] }, "reaction_10334535": { "compartment": "compartment_70101", "id": "reaction_10334535", "reactome": "R-XTR-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111353", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_197969" ], "modifiers": [ [ "species_10334532", "catalyst" ] ], "additional_components": [ "Q63ZT8", "ENSXETT00000084678" ] }, "reaction_10315634": { "compartment": "compartment_70101", "id": "reaction_10315634", "reactome": "R-XTR-200651", "name": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_200739" ], "products": [ "species_200736", "species_197969" ], "modifiers": [ [ "species_10311706", "catalyst" ] ], "additional_components": [ "A0A6I8QRM0", "ENSXETG00000005754" ] }, "reaction_10320707": { "compartment": "compartment_70101", "id": "reaction_10320707", "reactome": "R-XTR-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947539", "species_111707" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10320704", "catalyst" ] ], "additional_components": [ "ENSXETG00000038002" ] }, "reaction_10327276": { "compartment": "compartment_70101", "id": "reaction_10327276", "reactome": "R-XTR-3149494", "name": "MMACHC:cob(II)alamin binds MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327268", "species_10327246" ], "products": [ "species_10327270" ], "modifiers": [], "additional_components": [ "ENSXETG00000004524", "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "A0A6I8Q401", "ENSXETG00000004524" ] }, "reaction_10327279": { "compartment": "compartment_70101", "id": "reaction_10327279", "reactome": "R-XTR-3149519", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10327244", "species_3149505" ], "products": [ "species_29366", "species_10327246", "species_1130611" ], "modifiers": [ [ "species_10327244", "catalyst" ] ], "additional_components": [ "ENSXETG00000003502", "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "ENSXETG00000003502" ] }, "reaction_10327274": { "compartment": "compartment_70101", "id": "reaction_10327274", "reactome": "R-XTR-3149492", "name": "cob(II)alamin dissociates from MMACHC:MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327270" ], "products": [ "species_3149479", "species_10327272" ], "modifiers": [], "additional_components": [ "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "A0A6I8Q401", "ENSXETG00000004524", "A0A6I8Q1G4", "ENSXETG00000003502", "A0A6I8Q401", "ENSXETG00000004524" ] }, "reaction_10327290": { "compartment": "compartment_5460", "id": "reaction_10327290", "reactome": "R-XTR-3159253", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159260", "species_113593" ], "products": [ "species_3159274", "species_3159297" ], "modifiers": [ [ "species_10327287", "catalyst" ] ], "additional_components": [ "A0A6I8T0P0", "ENSXETG00000040875" ] }, "reaction_10327249": { "compartment": "compartment_70101", "id": "reaction_10327249", "reactome": "R-XTR-3095889", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000241", "species_70106", "species_29364", "species_10327244" ], "products": [ "species_29366", "species_10327246" ], "modifiers": [ [ "species_10327244", "catalyst" ] ], "additional_components": [ "ENSXETG00000003502", "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "ENSXETG00000003502" ] }, "reaction_10327281": { "compartment": "compartment_70101", "id": "reaction_10327281", "reactome": "R-XTR-3149563", "name": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327270" ], "products": [ "species_3149564", "species_10327272" ], "modifiers": [], "additional_components": [ "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "A0A6I8Q401", "ENSXETG00000004524", "A0A6I8Q1G4", "ENSXETG00000003502", "A0A6I8Q401", "ENSXETG00000004524" ] }, "reaction_10327186": { "compartment": "compartment_70101", "id": "reaction_10327186", "reactome": "R-XTR-3000238", "name": "LMBRD1 transports lysosomal Cbl to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000239" ], "products": [ "species_3000241" ], "modifiers": [ [ "species_10327183", "catalyst" ] ], "additional_components": [ "ENSXETT00000025716" ] }, "reaction_10327301": { "compartment": "compartment_70101", "id": "reaction_10327301", "reactome": "R-XTR-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965131" ], "products": [ "species_3204324", "species_29408" ], "modifiers": [ [ "species_10327298", "catalyst" ] ], "additional_components": [ "A0A6I8RQ40", "ENSXETG00000039500", "CHEBI:33722", "CHEBI:44074", "species_113596" ] }, "reaction_10314427": { "compartment": "compartment_70101", "id": "reaction_10314427", "reactome": "R-XTR-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497805", "species_10314424" ], "products": [ "species_10314422", "species_198816" ], "modifiers": [ [ "species_10314424", "catalyst" ] ], "additional_components": [ "F6WBG7", "ENSXETT00000038708", "species_189444", "species_917955", "F6WBG7", "ENSXETT00000038708", "F6WBG7", "ENSXETT00000038708", "species_189444" ] }, "reaction_10314434": { "compartment": "compartment_876", "id": "reaction_10314434", "reactome": "R-XTR-198870", "name": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198836", "species_74113" ], "products": [ "species_83910", "species_198816" ], "modifiers": [ [ "species_10314431", "catalyst" ] ], "additional_components": [ "ENSXETT00000099885" ] }, "reaction_10326701": { "compartment": "compartment_70101", "id": "reaction_10326701", "reactome": "R-XTR-2395764", "name": "atREs binds to nascent CM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326405", "species_2534423" ], "products": [ "species_10326407" ], "modifiers": [], "additional_components": [ "species_171126", "species_171142", "A0A6I8RKY6", "ENSXETG00000026768", "A0A6I8PU04", "ENSXETG00000033423", "species_216762", "species_163579", "A0A6I8SNZ3", "ENSXETG00000038088", "Q08BT8", "ENSXETT00000008146", "species_2534407", "CHEBI:70762", "CHEBI:70760", "CHEBI:70761", "species_2534407", "CHEBI:70762", "CHEBI:70760", "CHEBI:70761", "species_171126", "species_171142", "A0A6I8RKY6", "ENSXETG00000026768", "A0A6I8PU04", "ENSXETG00000033423", "species_216762", "species_163579", "A0A6I8SNZ3", "ENSXETG00000038088", "Q08BT8", "ENSXETT00000008146" ] }, "reaction_10326780": { "compartment": "compartment_984", "id": "reaction_10326780", "reactome": "R-XTR-2404135", "name": "RBP4 binds atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395761", "species_10326766" ], "products": [ "species_10326768" ], "modifiers": [], "additional_components": [ "ENSXETT00000008077", "F6UH11", "ENSXETT00000008077", "species_30209" ] }, "reaction_10326411": { "compartment": "compartment_70101", "id": "reaction_10326411", "reactome": "R-XTR-2187332", "name": "Cytosolic CMs translocate to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326407" ], "products": [ "species_10326409" ], "modifiers": [], "additional_components": [ "species_2534407", "CHEBI:70762", "CHEBI:70760", "CHEBI:70761", "species_171126", "species_171142", "A0A6I8RKY6", "ENSXETG00000026768", "A0A6I8PU04", "ENSXETG00000033423", "species_216762", "species_163579", "A0A6I8SNZ3", "ENSXETG00000038088", "Q08BT8", "ENSXETT00000008146", "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "CHEBI:70760", "species_2534407", "CHEBI:70762", "CHEBI:70761", "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "A0A6I8SNZ3", "ENSXETG00000038088", "Q08BT8", "ENSXETT00000008146", "species_216762" ] }, "reaction_10320762": { "compartment": "compartment_984", "id": "reaction_10320762", "reactome": "R-XTR-975593", "name": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_975591" ], "products": [ "species_975590", "species_426576" ], "modifiers": [ [ "species_10314239", "catalyst" ] ], "additional_components": [ "F6ZWX1", "ENSXETT00000007508" ] }, "reaction_10326778": { "compartment": "compartment_984", "id": "reaction_10326778", "reactome": "R-XTR-2404134", "name": "RBP4:atROL binds TTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326768", "species_10326774" ], "products": [ "species_10326776" ], "modifiers": [], "additional_components": [ "F6UH11", "ENSXETT00000008077", "species_30209", "A4QNN7", "ENSXETT00000010246", "A4QNN7", "ENSXETT00000010246", "F6UH11", "ENSXETT00000008077", "species_30209" ] }, "reaction_10334456": { "compartment": "compartment_17957", "id": "reaction_10334456", "reactome": "R-XTR-6806674", "name": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806891", "species_6806657" ], "products": [ "species_6806362", "species_6806656" ], "modifiers": [ [ "species_10334453", "catalyst" ] ], "additional_components": [ "ENSXETG00000017414" ] }, "reaction_10323409": { "compartment": "compartment_70101", "id": "reaction_10323409", "reactome": "R-XTR-1497869", "name": "Salvage - Sepiapterin is reduced to BH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1497811", "species_29364" ], "products": [ "species_1497857", "species_29366" ], "modifiers": [ [ "species_10323229", "catalyst" ] ], "additional_components": [ "A0A6I8PWL6", "ENSXETG00000033127" ] }, "reaction_10323232": { "compartment": "compartment_70101", "id": "reaction_10323232", "reactome": "R-XTR-1475414", "name": "PTHP is reduced to BH4 by sepiapterin reductase (SPR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474179", "species_29364" ], "products": [ "species_29870", "species_29366" ], "modifiers": [ [ "species_10323229", "catalyst" ] ], "additional_components": [ "A0A6I8PWL6", "ENSXETG00000033127" ] }, "reaction_10323123": { "compartment": "compartment_70101", "id": "reaction_10323123", "reactome": "R-XTR-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10323120", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8S775", "ENSXETG00000034891" ] }, "reaction_10327167": { "compartment": "compartment_5460", "id": "reaction_10327167", "reactome": "R-XTR-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189444", "species_2162257", "species_113521" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10327164", "catalyst" ] ], "additional_components": [ "ENSXETG00000033101" ] }, "reaction_10314072": { "compartment": "compartment_70101", "id": "reaction_10314072", "reactome": "R-XTR-189425", "name": "UROD decarboxylates URO3 to COPRO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189407" ], "products": [ "species_189455", "species_113528" ], "modifiers": [ [ "species_10314069", "catalyst" ] ], "additional_components": [ "A0A6I8QYD9", "ENSXETG00000041183" ] }, "reaction_10314085": { "compartment": "compartment_70101", "id": "reaction_10314085", "reactome": "R-XTR-190141", "name": "ALAD binds to Pb2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190173", "species_10314078" ], "products": [ "species_10314083", "species_29426" ], "modifiers": [], "additional_components": [ "F7BED4", "ENSXETT00000050679", "species_29426", "F7BED4", "ENSXETT00000050679", "species_29426", "species_190173" ] }, "reaction_10314087": { "compartment": "compartment_70101", "id": "reaction_10314087", "reactome": "R-XTR-190182", "name": "UROD decarboxylates URO1 to COPRO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190157" ], "products": [ "species_113528", "species_190128" ], "modifiers": [ [ "species_10314069", "catalyst" ] ], "additional_components": [ "A0A6I8QYD9", "ENSXETG00000041183" ] }, "reaction_10314081": { "compartment": "compartment_70101", "id": "reaction_10314081", "reactome": "R-XTR-189439", "name": "ALAD condenses 2 dALAs to form PBG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189489" ], "products": [ "species_29356", "species_70106", "species_189464" ], "modifiers": [ [ "species_10314078", "catalyst" ] ], "additional_components": [ "F7BED4", "ENSXETT00000050679", "species_29426" ] }, "reaction_10338037": { "compartment": "compartment_70101", "id": "reaction_10338037", "reactome": "R-XTR-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338035" ], "products": [ "species_189386", "species_10313560" ], "modifiers": [], "additional_components": [ "A0A6I8S817", "ENSXETG00000036388", "species_189386", "ENSXETG00000036388" ] }, "reaction_10338039": { "compartment": "compartment_70101", "id": "reaction_10338039", "reactome": "R-XTR-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10313560" ], "products": [ "species_10338035" ], "modifiers": [], "additional_components": [ "ENSXETG00000036388", "A0A6I8S817", "ENSXETG00000036388", "species_189386" ] }, "reaction_10311500": { "compartment": "compartment_70101", "id": "reaction_10311500", "reactome": "R-XTR-70581", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_76213" ], "products": [ "species_29406", "species_29448" ], "modifiers": [ [ "species_10311497", "catalyst" ] ], "additional_components": [ "F6VWW1", "ENSXETT00000039920" ] }, "reaction_10332346": { "compartment": "compartment_70101", "id": "reaction_10332346", "reactome": "R-XTR-6787757", "name": "PXLP-K333-GADL1 decarboxylates acidic AAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787759" ], "products": [ "species_113528", "species_6787762" ], "modifiers": [ [ "species_10332343", "catalyst" ] ], "additional_components": [ "species_6787748", "species_29448", "CHEBI:17285", "species_73590", "species_1655445", "CHEBI:15891", "Q28D99", "ENSXETG00000014481" ] }, "reaction_10311511": { "compartment": "compartment_70101", "id": "reaction_10311511", "reactome": "R-XTR-70592", "name": "PXLP-K259-GOT1 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29448" ], "products": [ "species_29404", "species_76213" ], "modifiers": [ [ "species_10311497", "catalyst" ] ], "additional_components": [ "F6VWW1", "ENSXETT00000039920" ] }, "reaction_10331184": { "compartment": "compartment_70101", "id": "reaction_10331184", "reactome": "R-XTR-5691507", "name": "ASPA deacetylates NAA to acetate and L-aspartate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5691492" ], "products": [ "species_29416", "species_29448" ], "modifiers": [ [ "species_10331181", "catalyst" ] ], "additional_components": [ "species_29426", "Q28C61", "ENSXETG00000005789" ] }, "reaction_10336962": { "compartment": "compartment_5460", "id": "reaction_10336962", "reactome": "R-XTR-8954468", "name": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113553" ], "products": [ "species_29374", "species_8954466", "species_113529" ], "modifiers": [ [ "species_10336959", "catalyst" ] ], "additional_components": [ "ENSXETG00000002389" ] }, "reaction_10311532": { "compartment": "compartment_5460", "id": "reaction_10311532", "reactome": "R-XTR-70654", "name": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113585" ], "products": [ "species_31339", "species_113552" ], "modifiers": [ [ "species_10311529", "catalyst" ] ], "additional_components": [ "A0A6I8STU4", "ENSXETG00000040155" ] }, "reaction_10311513": { "compartment": "compartment_5460", "id": "reaction_10311513", "reactome": "R-XTR-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113521", "species_517495" ], "products": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "modifiers": [ [ "species_10311506", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29360", "species_113563", "species_113600", "species_73473", "Q5XGI4", "ENSXETT00000103326" ] }, "reaction_10332232": { "compartment": "compartment_5460", "id": "reaction_10332232", "reactome": "R-XTR-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10332229", "catalyst" ] ], "additional_components": [ "F7ALX3", "ENSXETT00000021260" ] }, "reaction_10311541": { "compartment": "compartment_5460", "id": "reaction_10311541", "reactome": "R-XTR-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10311538", "catalyst" ] ], "additional_components": [ "F7ALX3", "ENSXETT00000021260" ] }, "reaction_10311509": { "compartment": "compartment_5460", "id": "reaction_10311509", "reactome": "R-XTR-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "products": [ "species_113552", "species_113521", "species_517495" ], "modifiers": [ [ "species_10311506", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_113600", "species_73473", "species_29360", "species_113563", "Q5XGI4", "ENSXETT00000103326" ] }, "reaction_10336771": { "compartment": "compartment_70101", "id": "reaction_10336771", "reactome": "R-XTR-8942575", "name": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113592", "species_5691492" ], "products": [ "species_29370", "species_5693762" ], "modifiers": [ [ "species_10336766", "catalyst" ] ], "additional_components": [ "ENSXETG00000030755" ] }, "reaction_10311674": { "compartment": "compartment_70101", "id": "reaction_10311674", "reactome": "R-XTR-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_31365" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10311671", "catalyst" ] ], "additional_components": [ "species_198836", "species_435347", "F7AAG5", "ENSXETT00000008159" ] }, "reaction_10326051": { "compartment": "compartment_984", "id": "reaction_10326051", "reactome": "R-XTR-2160492", "name": "IL4I1:FAD oxidises L-Phe to kPPV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_351993", "species_352327" ], "products": [ "species_2022135", "species_351629", "species_2160466" ], "modifiers": [ [ "species_10326048", "catalyst" ] ], "additional_components": [ "A0A5S6N697", "ENSXETG00000031027", "species_113596" ] }, "reaction_10332252": { "compartment": "compartment_5460", "id": "reaction_10332252", "reactome": "R-XTR-6784423", "name": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784229" ], "products": [ "species_904849", "species_113557" ], "modifiers": [ [ "species_10332249", "catalyst" ] ], "additional_components": [ "Q5M8W9", "ENSXETT00000007453" ] }, "reaction_10332243": { "compartment": "compartment_5460", "id": "reaction_10332243", "reactome": "R-XTR-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10332240", "catalyst" ] ], "additional_components": [ "A0A6I8SGS7", "ENSXETG00000040955", "species_113596" ] }, "reaction_10334594": { "compartment": "compartment_17951", "id": "reaction_10334594", "reactome": "R-XTR-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_6810061" ], "products": [ "species_113575", "species_389843", "species_6810070" ], "modifiers": [ [ "species_10334591", "catalyst" ] ], "additional_components": [ "F6TSP3", "ENSXETT00000046108", "species_113596" ] }, "reaction_10311490": { "compartment": "compartment_5460", "id": "reaction_10311490", "reactome": "R-XTR-70555", "name": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113561", "species_29896" ], "products": [ "species_113548", "species_113581", "species_29676" ], "modifiers": [ [ "species_10311487", "catalyst" ], [ "species_30471", "catalyst" ] ], "additional_components": [ "ENSXETG00000006919" ] }, "reaction_10311481": { "compartment": "compartment_70101", "id": "reaction_10311481", "reactome": "R-XTR-70523", "name": "PXLP-K314-GPT transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29432" ], "products": [ "species_29404", "species_29398" ], "modifiers": [ [ "species_10311478", "catalyst" ] ], "additional_components": [ "Q28DB5", "ENSXETG00000007140" ] }, "reaction_10323908": { "compartment": "compartment_70101", "id": "reaction_10323908", "reactome": "R-XTR-1614654", "name": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352015", "species_174369" ], "products": [ "species_174390", "species_1614585" ], "modifiers": [ [ "species_10323905", "catalyst" ] ], "additional_components": [ "Q5M8Z0", "ENSXETT00000001133", "species_29426" ] }, "reaction_10331943": { "compartment": "compartment_70101", "id": "reaction_10331943", "reactome": "R-XTR-5696838", "name": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4789070", "species_174369" ], "products": [ "species_70106", "species_174390" ], "modifiers": [ [ "species_10331940", "catalyst" ] ], "additional_components": [ "species_29426", "Q5M8Z0", "ENSXETT00000001133" ] }, "reaction_10322223": { "compartment": "compartment_70101", "id": "reaction_10322223", "reactome": "R-XTR-1237096", "name": "Methylthio-ribose-P = Methylthio-ribulose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237165" ], "products": [ "species_1237107" ], "modifiers": [ [ "species_10322220", "catalyst" ] ], "additional_components": [ "ENSXETT00000047323" ] }, "reaction_10322232": { "compartment": "compartment_70101", "id": "reaction_10322232", "reactome": "R-XTR-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_1237155" ], "products": [ "species_29460", "species_1237122" ], "modifiers": [ [ "species_10322229", "catalyst" ] ], "additional_components": [ "species_435347", "Q6DIY2", "ENSXETT00000000659" ] }, "reaction_10322241": { "compartment": "compartment_70101", "id": "reaction_10322241", "reactome": "R-XTR-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1237176" ], "products": [ "species_29372", "species_70106", "species_1237155" ], "modifiers": [ [ "species_10322238", "catalyst" ] ], "additional_components": [ "Q28C69", "ENSXETG00000012582", "species_109496" ] }, "reaction_10334661": { "compartment": "compartment_70101", "id": "reaction_10334661", "reactome": "R-XTR-6814165", "name": "PXLP-K333-GADL1 decarboxylates CSA to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787748" ], "products": [ "species_1655445", "species_113528" ], "modifiers": [ [ "species_10332343", "catalyst" ] ], "additional_components": [ "Q28D99", "ENSXETG00000014481" ] }, "reaction_10311608": { "compartment": "compartment_70101", "id": "reaction_10311608", "reactome": "R-XTR-70906", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_34979" ], "products": [ "species_30158", "species_70106" ], "modifiers": [ [ "species_10311605", "catalyst" ] ], "additional_components": [ "ENSXETT00000046755" ] }, "reaction_10332309": { "compartment": "compartment_70101", "id": "reaction_10332309", "reactome": "R-XTR-6786245", "name": "CARNS1 transforms ATP, L-His, b-Ala to CARN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612", "species_113592", "species_73590" ], "products": [ "species_6786250", "species_29372", "species_29370" ], "modifiers": [ [ "species_10332306", "catalyst" ] ], "additional_components": [ "ENSXETG00000034643" ] }, "reaction_10311601": { "compartment": "compartment_70101", "id": "reaction_10311601", "reactome": "R-XTR-70903", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30721" ], "products": [ "species_34979" ], "modifiers": [ [ "species_10311598", "catalyst" ] ], "additional_components": [ "species_29360", "A0A6I8R5U8", "ENSXETG00000011543" ] }, "reaction_10336008": { "compartment": "compartment_5668575", "id": "reaction_10336008", "reactome": "R-XTR-8878581", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662670", "species_5668566" ], "products": [ "species_8878586", "species_5668574" ], "modifiers": [ [ "species_10336005", "catalyst" ] ], "additional_components": [ "ENSXETG00000012905" ] }, "reaction_10311617": { "compartment": "compartment_5460", "id": "reaction_10311617", "reactome": "R-XTR-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113556", "species_113521" ], "products": [ "species_113529", "species_508531", "species_29362" ], "modifiers": [ [ "species_10311614", "catalyst" ] ], "additional_components": [ "F7BQF6", "ENSXETT00000011316" ] }, "reaction_10336981": { "compartment": "compartment_5460", "id": "reaction_10336981", "reactome": "R-XTR-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_6784215" ], "products": [ "species_113590", "species_164934", "species_113521" ], "modifiers": [ [ "species_10332236", "catalyst" ] ], "additional_components": [ "ENSXETG00000040955" ] }, "reaction_10316697": { "compartment": "compartment_70101", "id": "reaction_10316697", "reactome": "R-XTR-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10316694", "catalyst" ] ], "additional_components": [ "ENSXETG00000039007" ] }, "reaction_10316699": { "compartment": "compartment_70101", "id": "reaction_10316699", "reactome": "R-XTR-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_353555", "species_76194" ], "modifiers": [ [ "species_10316694", "catalyst" ] ], "additional_components": [ "ENSXETG00000039007" ] }, "reaction_10316690": { "compartment": "compartment_70101", "id": "reaction_10316690", "reactome": "R-XTR-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10316687", "catalyst" ] ], "additional_components": [ "ENSXETG00000040919" ] }, "reaction_10311558": { "compartment": "compartment_70101", "id": "reaction_10311558", "reactome": "R-XTR-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10311555", "catalyst" ] ], "additional_components": [ "A0A6I8QKY2", "ENSXETG00000040919", "F6VJF3", "ENSXETT00000007603" ] }, "reaction_10311567": { "compartment": "compartment_5460", "id": "reaction_10311567", "reactome": "R-XTR-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10311564", "catalyst" ] ], "additional_components": [ "F7DXL6", "ENSXETT00000001790" ] }, "reaction_10311576": { "compartment": "compartment_5460", "id": "reaction_10311576", "reactome": "R-XTR-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70718", "species_113596" ], "products": [ "species_70799", "species_31649" ], "modifiers": [ [ "species_10311573", "catalyst" ] ], "additional_components": [ "species_113596", "F6VHN6", "ENSXETT00000035066" ] }, "reaction_10311592": { "compartment": "compartment_5460", "id": "reaction_10311592", "reactome": "R-XTR-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10311589", "catalyst" ] ], "additional_components": [ "ENSXETT00000033364" ] }, "reaction_10311585": { "compartment": "compartment_5460", "id": "reaction_10311585", "reactome": "R-XTR-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10311582", "catalyst" ] ], "additional_components": [ "Q5BKN8", "ENSXETT00000031684" ] }, "reaction_10311725": { "compartment": "compartment_70101", "id": "reaction_10311725", "reactome": "R-XTR-71286", "name": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_30401" ], "products": [ "species_29916", "species_70106", "species_71285" ], "modifiers": [ [ "species_10311722", "catalyst" ] ], "additional_components": [ "ENSXETG00000003703" ] }, "reaction_10311718": { "compartment": "compartment_17927", "id": "reaction_10311718", "reactome": "R-XTR-71275", "name": "arginine + glycine => ornithine + guanidoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113530", "species_113545" ], "products": [ "species_113543", "species_113586" ], "modifiers": [ [ "species_10311715", "catalyst" ] ], "additional_components": [ "Q6P832", "ENSXETT00000035125" ] }, "reaction_10332468": { "compartment": "compartment_5460", "id": "reaction_10332468", "reactome": "R-XTR-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_6798194", "species_113521" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10311612", "catalyst" ] ], "additional_components": [ "ENSXETT00000011316" ] }, "reaction_10311690": { "compartment": "compartment_70101", "id": "reaction_10311690", "reactome": "R-XTR-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_29970" ], "products": [ "species_34351", "species_29356", "species_29366" ], "modifiers": [ [ "species_10311687", "catalyst" ] ], "additional_components": [ "ENSXETT00000035436" ] }, "reaction_10311683": { "compartment": "compartment_70101", "id": "reaction_10311683", "reactome": "R-XTR-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29500", "species_29368" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10311680", "catalyst" ] ], "additional_components": [ "species_189444", "Q5EBG2", "ENSXETT00000048482" ] }, "reaction_10311699": { "compartment": "compartment_70101", "id": "reaction_10311699", "reactome": "R-XTR-71218", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30487" ], "products": [ "species_36027" ], "modifiers": [ [ "species_10311696", "catalyst" ] ], "additional_components": [ "Q6DIZ0", "ENSXETG00000015771", "species_435347" ] }, "reaction_10326790": { "compartment": "compartment_70101", "id": "reaction_10326790", "reactome": "R-XTR-2408524", "name": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5359016", "species_5357697" ], "products": [ "species_5357660", "species_29432", "species_5359011" ], "modifiers": [ [ "species_10326787", "catalyst" ] ], "additional_components": [ "Q5U4Q9", "ENSXETT00000026454" ] }, "reaction_10311709": { "compartment": "compartment_70101", "id": "reaction_10311709", "reactome": "R-XTR-71249", "name": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31503" ], "products": [ "species_31311", "species_29424" ], "modifiers": [ [ "species_10311706", "catalyst" ] ], "additional_components": [ "A0A6I8QRM0", "ENSXETG00000005754" ] }, "reaction_10311917": { "compartment": "compartment_70101", "id": "reaction_10311917", "reactome": "R-XTR-73632", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_83928" ], "products": [ "species_29370", "species_109366" ], "modifiers": [ [ "species_10311914", "catalyst" ] ], "additional_components": [ "A0A6I8SMB6", "ENSXETG00000001323" ] }, "reaction_10312345": { "compartment": "compartment_70101", "id": "reaction_10312345", "reactome": "R-XTR-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10312342", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_727810", "species_109402", "B1H116", "ENSXETT00000037794" ] }, "reaction_10311908": { "compartment": "compartment_70101", "id": "reaction_10311908", "reactome": "R-XTR-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500829" ], "products": [ "species_500430", "species_31633" ], "modifiers": [ [ "species_10311905", "catalyst" ] ], "additional_components": [ "CHEBI:15698", "CHEBI:17562", "CHEBI:16450", "CHEBI:16704", "species_29426", "A0A6I8SN57", "ENSXETG00000037611" ] }, "reaction_10311993": { "compartment": "compartment_70101", "id": "reaction_10311993", "reactome": "R-XTR-74241", "name": "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500173" ], "products": [ "species_500172", "species_31633" ], "modifiers": [ [ "species_10311990", "catalyst" ] ], "additional_components": [ "species_8857850", "CHEBI:17256", "CHEBI:28997", "species_83927", "ENSXETG00000003459" ] }, "reaction_10312600": { "compartment": "compartment_70101", "id": "reaction_10312600", "reactome": "R-XTR-112033", "name": "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_500244" ], "products": [ "species_29372", "species_500172" ], "modifiers": [ [ "species_10311999", "catalyst" ] ], "additional_components": [ "CHEBI:28542", "CHEBI:35425", "CHEBI:28997", "species_83927", "A0A6I8SRS9", "ENSXETG00000016932" ] }, "reaction_10312602": { "compartment": "compartment_70101", "id": "reaction_10312602", "reactome": "R-XTR-112034", "name": "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83956", "species_500244" ], "products": [ "species_29372", "species_500245" ], "modifiers": [ [ "species_10311999", "catalyst" ] ], "additional_components": [ "CHEBI:28542", "CHEBI:35425", "CHEBI:17172", "CHEBI:16750", "A0A6I8SRS9", "ENSXETG00000016932" ] }, "reaction_10312245": { "compartment": "compartment_70101", "id": "reaction_10312245", "reactome": "R-XTR-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76577" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10312242", "catalyst" ] ], "additional_components": [ "A0A6I8SRY8", "ENSXETG00000002009" ] }, "reaction_10311986": { "compartment": "compartment_70101", "id": "reaction_10311986", "reactome": "R-XTR-74215", "name": "guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_500259" ], "products": [ "species_111294", "species_500260" ], "modifiers": [ [ "species_10311983", "catalyst" ] ], "additional_components": [ "species_83956", "species_113599", "species_29602", "species_5696194", "A0A6I8SQB1", "ENSXETG00000019768", "species_109496" ] }, "reaction_10312364": { "compartment": "compartment_70101", "id": "reaction_10312364", "reactome": "R-XTR-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_6788778", "species_113592" ], "modifiers": [ [ "species_10312361", "catalyst" ] ], "additional_components": [ "species_29370", "CHEBI:28846", "CHEBI:16174", "CHEBI:17239", "species_159448", "species_727810", "CHEBI:15918", "CHEBI:17713", "Q6P618", "ENSXETG00000006260", "A0A6I8Q090", "ENSXETG00000033226" ] }, "reaction_10312076": { "compartment": "compartment_70101", "id": "reaction_10312076", "reactome": "R-XTR-75125", "name": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_500006" ], "products": [ "species_500009", "species_113592" ], "modifiers": [ [ "species_10311896", "catalyst" ] ], "additional_components": [ "species_417888", "CHEBI:28846", "CHEBI:17239", "species_727810", "CHEBI:15918", "species_109402", "ENSXETG00000036011" ] }, "reaction_10312366": { "compartment": "compartment_70101", "id": "reaction_10312366", "reactome": "R-XTR-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788778", "species_113592" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10312361", "catalyst" ] ], "additional_components": [ "species_159448", "species_727810", "CHEBI:15918", "CHEBI:17713", "species_29370", "CHEBI:28846", "CHEBI:16174", "CHEBI:17239", "Q6P618", "ENSXETG00000006260", "A0A6I8Q090", "ENSXETG00000033226" ] }, "reaction_10312373": { "compartment": "compartment_70101", "id": "reaction_10312373", "reactome": "R-XTR-110144", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_113592", "species_76577" ], "modifiers": [ [ "species_10312370", "catalyst" ] ], "additional_components": [ "ENSXETT00000057918" ] }, "reaction_10312550": { "compartment": "compartment_70101", "id": "reaction_10312550", "reactome": "R-XTR-111746", "name": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312547", "species_29450" ], "products": [ "species_10312544", "species_111745" ], "modifiers": [ [ "species_10312547", "catalyst" ] ], "additional_components": [ "ENSXETG00000026267", "ENSXETG00000026267", "ENSXETG00000026267" ] }, "reaction_10311926": { "compartment": "compartment_7660", "id": "reaction_10311926", "reactome": "R-XTR-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742" ], "modifiers": [ [ "species_10311923", "catalyst" ] ], "additional_components": [ "A0A6I8RWX6", "ENSXETG00000036738" ] }, "reaction_10326748": { "compartment": "compartment_70101", "id": "reaction_10326748", "reactome": "R-XTR-2395879", "name": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395883", "species_29356" ], "products": [ "species_2395817", "species_29372" ], "modifiers": [ [ "species_10326740", "catalyst" ] ], "additional_components": [ "ENSXETG00000037630" ] }, "reaction_10326751": { "compartment": "compartment_70101", "id": "reaction_10326751", "reactome": "R-XTR-2395965", "name": "NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395963", "species_29356" ], "products": [ "species_29372", "species_2395964" ], "modifiers": [ [ "species_10326740", "catalyst" ] ], "additional_components": [ "ENSXETG00000037630" ] }, "reaction_10326734": { "compartment": "compartment_70101", "id": "reaction_10326734", "reactome": "R-XTR-2395869", "name": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395852" ], "products": [ "species_111294", "species_2395817" ], "modifiers": [ [ "species_10326731", "catalyst" ] ], "additional_components": [ "ENSXETG00000039868" ] }, "reaction_10326746": { "compartment": "compartment_70101", "id": "reaction_10326746", "reactome": "R-XTR-2395876", "name": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395883", "species_29356" ], "products": [ "species_2395817", "species_29372" ], "modifiers": [ [ "species_10326731", "catalyst" ] ], "additional_components": [ "ENSXETG00000039868" ] }, "reaction_10326724": { "compartment": "compartment_70101", "id": "reaction_10326724", "reactome": "R-XTR-2395818", "name": "NUDT1 hydrolyses 2-OH-dATP to 2-OH-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395822" ], "products": [ "species_111294", "species_2395855" ], "modifiers": [ [ "species_10326721", "catalyst" ] ], "additional_components": [ "species_109496", "Q6GL35", "ENSXETT00000085967" ] }, "reaction_10326727": { "compartment": "compartment_70101", "id": "reaction_10326727", "reactome": "R-XTR-2395849", "name": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395852" ], "products": [ "species_111294", "species_2395817" ], "modifiers": [ [ "species_10326721", "catalyst" ] ], "additional_components": [ "species_109496", "Q6GL35", "ENSXETT00000085967" ] }, "reaction_10326743": { "compartment": "compartment_70101", "id": "reaction_10326743", "reactome": "R-XTR-2395873", "name": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395880" ], "products": [ "species_29372", "species_2395877" ], "modifiers": [ [ "species_10326740", "catalyst" ] ], "additional_components": [ "ENSXETG00000037630" ] }, "reaction_10331430": { "compartment": "compartment_70101", "id": "reaction_10331430", "reactome": "R-XTR-5696049", "name": "ADPRM hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1131972" ], "products": [ "species_73578", "species_76577" ], "modifiers": [ [ "species_10331427", "catalyst" ] ], "additional_components": [ "CHEBI:29035", "Q66JJ3", "ENSXETT00000024142" ] }, "reaction_10326736": { "compartment": "compartment_70101", "id": "reaction_10326736", "reactome": "R-XTR-2395872", "name": "NUDT1 hydrolyses 2-OH-ATP to 2-OH-AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395868" ], "products": [ "species_111294", "species_2395878" ], "modifiers": [ [ "species_10326721", "catalyst" ] ], "additional_components": [ "species_109496", "Q6GL35", "ENSXETT00000085967" ] }, "reaction_10312296": { "compartment": "compartment_70101", "id": "reaction_10312296", "reactome": "R-XTR-109387", "name": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500125" ], "products": [ "species_29372", "species_500124" ], "modifiers": [ [ "species_10312291", "catalyst" ], [ "species_29370", "catalyst" ] ], "additional_components": [ "species_159448", "species_29602", "species_109330", "CHEBI:17713", "species_5696194", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_8857850", "CHEBI:17256", "species_83927", "CHEBI:16750", "species_109496", "A0A6I8QEC6", "ENSXETG00000037368" ] }, "reaction_10326856": { "compartment": "compartment_70101", "id": "reaction_10326856", "reactome": "R-XTR-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_111294", "species_109330" ], "modifiers": [ [ "species_10326847", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "A0A6I8SWT3", "ENSXETG00000036089" ] }, "reaction_10312011": { "compartment": "compartment_70101", "id": "reaction_10312011", "reactome": "R-XTR-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500120", "species_29356" ], "products": [ "species_29372", "species_500118" ], "modifiers": [ [ "species_10312008", "catalyst" ] ], "additional_components": [ "species_29602", "species_109330", "species_5696194", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_83927", "CHEBI:16750", "species_109496", "Q5EBF1", "ENSXETG00000009475" ] }, "reaction_10326853": { "compartment": "compartment_70101", "id": "reaction_10326853", "reactome": "R-XTR-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_111294", "species_111584" ], "modifiers": [ [ "species_10326847", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "A0A6I8SWT3", "ENSXETG00000036089" ] }, "reaction_10312305": { "compartment": "compartment_70101", "id": "reaction_10312305", "reactome": "R-XTR-109470", "name": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500120", "species_29356" ], "products": [ "species_29372", "species_500118" ], "modifiers": [ [ "species_10312302", "catalyst" ] ], "additional_components": [ "species_29602", "species_109330", "species_5696194", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_83927", "CHEBI:16750", "A0A6I8QJ17", "ENSXETG00000037325", "species_109496" ] }, "reaction_10326850": { "compartment": "compartment_70101", "id": "reaction_10326850", "reactome": "R-XTR-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_111294", "species_29602" ], "modifiers": [ [ "species_10326847", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "A0A6I8SWT3", "ENSXETG00000036089" ] }, "reaction_10312314": { "compartment": "compartment_5460", "id": "reaction_10312314", "reactome": "R-XTR-109514", "name": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500420", "species_113521" ], "products": [ "species_113548", "species_500421" ], "modifiers": [ [ "species_10312311", "catalyst" ] ], "additional_components": [ "species_109366", "species_500742", "CHEBI:28895", "species_109402", "CHEBI:28070", "species_83928", "CHEBI:16450", "CHEBI:16704", "A0A6I8QJ17", "ENSXETG00000037325", "species_109496" ] }, "reaction_10312294": { "compartment": "compartment_70101", "id": "reaction_10312294", "reactome": "R-XTR-109380", "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500347" ], "products": [ "species_500346", "species_29372" ], "modifiers": [ [ "species_10312291", "catalyst" ], [ "species_29370", "catalyst" ] ], "additional_components": [ "species_727810", "CHEBI:15918", "species_109366", "species_500742", "species_109402", "CHEBI:15698", "CHEBI:16450", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_109496", "A0A6I8QEC6", "ENSXETG00000037368" ] }, "reaction_10312307": { "compartment": "compartment_70101", "id": "reaction_10312307", "reactome": "R-XTR-109480", "name": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500414" ], "products": [ "species_29372", "species_500415" ], "modifiers": [ [ "species_10312302", "catalyst" ] ], "additional_components": [ "CHEBI:28070", "CHEBI:28895", "species_109366", "species_500742", "CHEBI:46322", "species_109402", "CHEBI:16450", "CHEBI:16704", "species_83928", "A0A6I8QJ17", "ENSXETG00000037325", "species_109496" ] }, "reaction_10334973": { "compartment": "compartment_984", "id": "reaction_10334973", "reactome": "R-XTR-8851356", "name": "NTPDase5 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8936165" ], "products": [ "species_8851369", "species_109277" ], "modifiers": [ [ "species_10334970", "catalyst" ] ], "additional_components": [ "species_29370", "species_417888", "species_29420", "CHEBI:17239", "species_109402", "species_727810", "species_5696194", "species_159448", "A0A6I8Q679", "ENSXETG00000030591", "species_109496", "species_74112" ] }, "reaction_10334998": { "compartment": "compartment_528865", "id": "reaction_10334998", "reactome": "R-XTR-8851494", "name": "NTPDase7 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851517", "species_8851509" ], "products": [ "species_8851513", "species_8851518" ], "modifiers": [ [ "species_10334995", "catalyst" ] ], "additional_components": [ "CHEBI:15713", "species_29438", "CHEBI:17677", "CHEBI:17239", "species_417888", "species_29420", "species_74112", "Q28CF8", "ENSXETG00000003746" ] }, "reaction_10334848": { "compartment": "compartment_984", "id": "reaction_10334848", "reactome": "R-XTR-8850846", "name": "NTPDase1 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8870907" ], "products": [ "species_8870906", "species_109277" ], "modifiers": [ [ "species_10334845", "catalyst" ] ], "additional_components": [ "A0A6I8QSY1", "ENSXETG00000037156", "species_109496", "species_74112" ] }, "reaction_10334960": { "compartment": "compartment_984", "id": "reaction_10334960", "reactome": "R-XTR-8851089", "name": "NTPDase2 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936166", "species_109276" ], "products": [ "species_109277", "species_8851092" ], "modifiers": [ [ "species_10334957", "catalyst" ] ], "additional_components": [ "species_2509836", "species_29438", "CHEBI:15713", "CHEBI:17677", "species_113593", "CHEBI:17808", "species_29370", "species_417888", "species_29420", "CHEBI:17239", "K9J7Q8", "ENSXETT00000008576", "species_109496", "species_74112" ] }, "reaction_10334851": { "compartment": "compartment_876", "id": "reaction_10334851", "reactome": "R-XTR-8850854", "name": "NTPDase1 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8870906" ], "products": [ "species_109277", "species_8870962" ], "modifiers": [ [ "species_10334845", "catalyst" ] ], "additional_components": [ "A0A6I8QSY1", "ENSXETG00000037156", "species_109496", "species_74112" ] }, "reaction_10311933": { "compartment": "compartment_70101", "id": "reaction_10311933", "reactome": "R-XTR-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_111584", "species_29472" ], "products": [ "species_111294", "species_29404", "species_113578", "species_76577" ], "modifiers": [ [ "species_10311930", "catalyst" ] ], "additional_components": [ "ENSXETG00000033049" ] }, "reaction_10312540": { "compartment": "compartment_70101", "id": "reaction_10312540", "reactome": "R-XTR-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29448", "species_29602" ], "products": [ "species_29372", "species_29420", "species_35141" ], "modifiers": [ [ "species_10312537", "catalyst" ], [ "species_30014", "inhibitor" ], [ "species_29420", "inhibitor" ], [ "species_35141", "inhibitor" ], [ "species_113578", "inhibitor" ] ], "additional_components": [ "Q6DIW6", "ENSXETG00000024695", "species_109496", "Q6P875", "ENSXETG00000014538" ] }, "reaction_10311946": { "compartment": "compartment_70101", "id": "reaction_10311946", "reactome": "R-XTR-73814", "name": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111292", "species_113592", "species_29424" ], "products": [ "species_29372", "species_111338", "species_29370" ], "modifiers": [ [ "species_10311937", "catalyst" ] ], "additional_components": [ "ENSXETG00000014148" ] }, "reaction_10311940": { "compartment": "compartment_70101", "id": "reaction_10311940", "reactome": "R-XTR-73810", "name": "FGAM + ATP => AIR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111369" ], "products": [ "species_29372", "species_111370", "species_29370" ], "modifiers": [ [ "species_10311937", "catalyst" ] ], "additional_components": [ "ENSXETG00000014148" ] }, "reaction_10311943": { "compartment": "compartment_70101", "id": "reaction_10311943", "reactome": "R-XTR-73813", "name": "GAR + 10-Formyl-THF => FGAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111338", "species_419151" ], "products": [ "species_111354", "species_111355" ], "modifiers": [ [ "species_10311937", "catalyst" ] ], "additional_components": [ "ENSXETG00000014148" ] }, "reaction_10332370": { "compartment": "compartment_70101", "id": "reaction_10332370", "reactome": "R-XTR-6788912", "name": "LHPP:Mg2+ dimer hydrolyses PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10332367", "catalyst" ] ], "additional_components": [ "A0A6I8PWJ2", "ENSXETG00000031230", "species_109496" ] }, "reaction_10315931": { "compartment": "compartment_70101", "id": "reaction_10315931", "reactome": "R-XTR-203553", "name": "eNOS binds NOSIP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315923", "species_10315927" ], "products": [ "species_10315929" ], "modifiers": [], "additional_components": [ "species_189444", "species_29426", "species_73524", "species_113596", "A0A6I8RYH7", "ENSXETG00000011979", "ENSXETT00000065273", "Q6P829", "ENSXETT00000065273", "species_189444", "species_29426", "species_73524", "species_113596", "A0A6I8RYH7", "ENSXETG00000011979" ] }, "reaction_10315952": { "compartment": "compartment_876", "id": "reaction_10315952", "reactome": "R-XTR-203680", "name": "eNOS:NOSIP translocation from caveolae to intracellular compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315929" ], "products": [ "species_10315950" ], "modifiers": [], "additional_components": [ "Q6P829", "ENSXETT00000065273", "species_189444", "species_29426", "species_73524", "species_113596", "A0A6I8RYH7", "ENSXETG00000011979", "Q6P829", "ENSXETT00000065273", "A0A6I8RYH7", "ENSXETG00000011979", "species_189444", "species_29426", "species_73524", "species_113596", "species_29870" ] }, "reaction_10315944": { "compartment": "compartment_70101", "id": "reaction_10315944", "reactome": "R-XTR-203611", "name": "N-myristoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_184174", "species_10315942" ], "products": [ "species_10315712" ], "modifiers": [], "additional_components": [ "ENSXETG00000011979", "ENSXETG00000011979" ] }, "reaction_10315720": { "compartment": "compartment_20699", "id": "reaction_10315720", "reactome": "R-XTR-202132", "name": "depalmitoylated eNOS translocates from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315714" ], "products": [ "species_10315718" ], "modifiers": [], "additional_components": [ "species_189444", "species_29426", "species_73524", "species_113596", "A0A6I8RYH7", "ENSXETG00000011979", "species_29870", "species_189444", "species_29426", "species_73524", "A0A6I8RYH7", "ENSXETG00000011979", "species_113596", "species_29870" ] }, "reaction_10315940": { "compartment": "compartment_20699", "id": "reaction_10315940", "reactome": "R-XTR-203567", "name": "palmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315712", "species_200993" ], "products": [ "species_10315933" ], "modifiers": [ [ "species_10315937", "catalyst" ] ], "additional_components": [ "ENSXETG00000011979", "ENSXETG00000011979", "ENSXETT00000055800" ] }, "reaction_10329588": { "compartment": "compartment_70101", "id": "reaction_10329588", "reactome": "R-XTR-5340226", "name": "CYGB dioxygenates NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_202124", "species_70106", "species_29364", "species_10329583" ], "products": [ "species_432031", "species_29366", "species_10329581" ], "modifiers": [ [ "species_10329583", "catalyst" ] ], "additional_components": [ "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_113533", "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_113533" ] }, "reaction_10329585": { "compartment": "compartment_70101", "id": "reaction_10329585", "reactome": "R-XTR-5340214", "name": "CYGB binds O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_10329581" ], "products": [ "species_10329583" ], "modifiers": [], "additional_components": [ "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_113533" ] }, "reaction_10315954": { "compartment": "compartment_20699", "id": "reaction_10315954", "reactome": "R-XTR-203700", "name": "eNOS translocation from Golgi to Caveolae", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315933" ], "products": [ "species_10315923" ], "modifiers": [], "additional_components": [ "ENSXETG00000011979", "species_189444", "species_29426", "species_73524", "species_113596", "A0A6I8RYH7", "ENSXETG00000011979" ] }, "reaction_10313418": { "compartment": "compartment_70616", "id": "reaction_10313418", "reactome": "R-XTR-170026", "name": "Protons are translocated from the intermembrane space to the matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163953" ], "products": [ "species_113529" ], "modifiers": [ [ "species_10313240", "catalyst" ], [ "species_30495", "catalyst" ], [ "species_170037", "inhibitor" ] ], "additional_components": [ "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_113593", "species_29370", "species_29420", "species_29438" ] }, "reaction_10313247": { "compartment": "compartment_70616", "id": "reaction_10313247", "reactome": "R-XTR-166214", "name": "FA anion flip-flops to the opposite surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313242" ], "products": [ "species_10313244" ], "modifiers": [ [ "species_10313242", "catalyst" ] ], "additional_components": [ "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_166216", "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_166216", "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_166216" ] }, "reaction_10313249": { "compartment": "compartment_70616", "id": "reaction_10313249", "reactome": "R-XTR-166220", "name": "FA anion diffuses laterally to UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_166213", "species_10313240" ], "products": [ "species_10313242" ], "modifiers": [], "additional_components": [ "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_166216" ] }, "reaction_10313251": { "compartment": "compartment_70616", "id": "reaction_10313251", "reactome": "R-XTR-166387", "name": "The FA anion diffuses away laterally from UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313244" ], "products": [ "species_166216", "species_10313240" ], "modifiers": [], "additional_components": [ "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_166216", "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740" ] }, "reaction_10338068": { "compartment": "compartment_984", "id": "reaction_10338068", "reactome": "R-XTR-9673054", "name": "PM20D1 hydrolyzes oleoyl-phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_9673044" ], "products": [ "species_351993", "species_9673048" ], "modifiers": [ [ "species_10338063", "catalyst" ] ], "additional_components": [ "ENSXETG00000005950" ] }, "reaction_10338066": { "compartment": "compartment_984", "id": "reaction_10338066", "reactome": "R-XTR-9673053", "name": "PM20D1 transforms oleoyl-phe from oleate and phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351993", "species_9673048" ], "products": [ "species_109276", "species_9673044" ], "modifiers": [ [ "species_10338063", "catalyst" ] ], "additional_components": [ "ENSXETG00000005950" ] }, "reaction_10320175": { "compartment": "compartment_5460", "id": "reaction_10320175", "reactome": "R-XTR-880002", "name": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_880046", "species_879997" ], "products": [ "species_113594", "species_880041" ], "modifiers": [ [ "species_10320172", "catalyst" ] ], "additional_components": [ "ENSXETG00000023251" ] }, "reaction_10332223": { "compartment": "compartment_70101", "id": "reaction_10332223", "reactome": "R-XTR-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29708", "species_29450" ], "modifiers": [ [ "species_10332220", "catalyst" ] ], "additional_components": [ "species_29426", "B4F6K2", "ENSXETG00000007202" ] }, "reaction_10337199": { "compartment": "compartment_5460", "id": "reaction_10337199", "reactome": "R-XTR-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_113557", "species_29376" ], "modifiers": [ [ "species_10337196", "catalyst" ] ], "additional_components": [ "A0A6I8PLR1", "ENSXETG00000033843", "species_109496" ] }, "reaction_10318622": { "compartment": "compartment_5460", "id": "reaction_10318622", "reactome": "R-XTR-450984", "name": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_29938" ], "products": [ "species_113594", "species_113529", "species_113600", "species_29376" ], "modifiers": [ [ "species_10318619", "catalyst" ] ], "additional_components": [ "F6WI63", "ENSXETT00000017597", "CHEBI:29035" ] }, "reaction_10311626": { "compartment": "compartment_5460", "id": "reaction_10311626", "reactome": "R-XTR-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113587", "species_113521" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10311623", "catalyst" ] ], "additional_components": [ "Q28DK1", "ENSXETT00000020990" ] }, "reaction_10311649": { "compartment": "compartment_5460", "id": "reaction_10311649", "reactome": "R-XTR-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10311646", "catalyst" ] ], "additional_components": [ "Q6P355", "ENSXETT00000057629", "B0BM36", "ENSXETG00000013435", "Q28ED0", "ENSXETT00000087904", "species_113596" ] }, "reaction_10311869": { "compartment": "compartment_70101", "id": "reaction_10311869", "reactome": "R-XTR-71732", "name": "pyrophosphate + H2O => 2 orthophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10311866", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "A0A6I8S9S0", "ENSXETG00000014102" ] }, "reaction_10318570": { "compartment": "compartment_5460", "id": "reaction_10318570", "reactome": "R-XTR-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159450", "species_113521" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10318567", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "A0A6I8S9S0", "ENSXETG00000014102" ] }, "reaction_10330207": { "compartment": "compartment_70101", "id": "reaction_10330207", "reactome": "R-XTR-5652195", "name": "SORD oxidizes D-sorbitol to Fru", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5652213", "species_29360" ], "products": [ "species_29532", "species_70106", "species_73473" ], "modifiers": [ [ "species_10330204", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8PMG1", "ENSXETG00000023897" ] }, "reaction_10337689": { "compartment": "compartment_161320", "id": "reaction_10337689", "reactome": "R-XTR-9036727", "name": "GAA hydrolyzes lysosomal glycogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_10337678" ], "products": [ "species_10337682", "species_1605745" ], "modifiers": [ [ "species_10337684", "catalyst" ] ], "additional_components": [ "A0A6I8SJ17", "ENSXETG00000016072", "CHEBI:29035", "CHEBI:29035", "A0A6I8SJ17", "ENSXETG00000016072", "ENSXETT00000002749" ] }, "reaction_10337919": { "compartment": "compartment_70101", "id": "reaction_10337919", "reactome": "R-XTR-9638125", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10337916", "catalyst" ] ], "additional_components": [ "species_109496", "F6PKQ4", "ENSXETT00000023697" ] }, "reaction_10311436": { "compartment": "compartment_70101", "id": "reaction_10311436", "reactome": "R-XTR-70467", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_30014", "species_29370" ], "modifiers": [ [ "species_10311433", "catalyst" ], [ "species_30533", "catalyst" ], [ "species_29370", "catalyst" ], [ "species_76577", "catalyst" ], [ "species_76190", "inhibitor" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "A0A6I8RGQ8", "ENSXETG00000007279" ] }, "reaction_10333611": { "compartment": "compartment_70101", "id": "reaction_10333611", "reactome": "R-XTR-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_449701" ], "products": [ "species_29512", "species_31633" ], "modifiers": [ [ "species_10333608", "catalyst" ] ], "additional_components": [ "A4IHW6", "ENSXETT00000018476" ] }, "reaction_10311418": { "compartment": "compartment_70101", "id": "reaction_10311418", "reactome": "R-XTR-70420", "name": "HK1,2,3,GCK phosphorylate Glc to form G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_70113" ], "products": [ "species_70106", "species_29370", "species_30537" ], "modifiers": [ [ "species_10311413", "catalyst" ] ], "additional_components": [ "ENSXETT00000005874" ] }, "reaction_10311878": { "compartment": "compartment_70101", "id": "reaction_10311878", "reactome": "R-XTR-71850", "name": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_29800" ], "products": [ "species_113592", "species_29728" ], "modifiers": [ [ "species_10311459", "catalyst" ] ], "additional_components": [ "A0A6I8SHY7", "ENSXETG00000007447", "species_109496" ] }, "reaction_10311427": { "compartment": "compartment_70101", "id": "reaction_10311427", "reactome": "R-XTR-70454", "name": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75970" ], "products": [ "species_29578" ], "modifiers": [ [ "species_10311424", "catalyst" ] ], "additional_components": [ "B0BM40", "ENSXETG00000023924" ] }, "reaction_10327532": { "compartment": "compartment_17957", "id": "reaction_10327532", "reactome": "R-XTR-3262512", "name": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_113782" ], "products": [ "species_113551", "species_113780" ], "modifiers": [ [ "species_10327529", "catalyst" ] ], "additional_components": [ "ENSXETG00000032824" ] }, "reaction_10311471": { "compartment": "compartment_5460", "id": "reaction_10311471", "reactome": "R-XTR-70501", "name": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113557", "species_29376" ], "products": [ "species_113548", "species_113581", "species_113587" ], "modifiers": [ [ "species_10311468", "catalyst" ], [ "species_113559", "catalyst" ] ], "additional_components": [ "CHEBI:29035", "A0A6I8QW74", "ENSXETG00000008415", "species_199207" ] }, "reaction_10314378": { "compartment": "compartment_70101", "id": "reaction_10314378", "reactome": "R-XTR-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_29360" ], "products": [ "species_70106", "species_76213", "species_73473" ], "modifiers": [ [ "species_10314375", "catalyst" ] ], "additional_components": [ "Q6DIY9", "ENSXETT00000101573" ] }, "reaction_10311445": { "compartment": "compartment_70101", "id": "reaction_10311445", "reactome": "R-XTR-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10311442", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "species_109496", "Q6P8F7", "ENSXETT00000049063" ] }, "reaction_10327525": { "compartment": "compartment_70101", "id": "reaction_10327525", "reactome": "R-XTR-3257122", "name": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113551", "species_30537" ], "products": [ "species_29372", "species_113782" ], "modifiers": [ [ "species_10327522", "catalyst" ] ], "additional_components": [ "ENSXETT00000094617" ] }, "reaction_10311876": { "compartment": "compartment_17957", "id": "reaction_10311876", "reactome": "R-XTR-71825", "name": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_113782" ], "products": [ "species_113551", "species_113780" ], "modifiers": [ [ "species_10311873", "catalyst" ] ], "additional_components": [ "ENSXETT00000033981" ] }, "reaction_10325949": { "compartment": "compartment_20699", "id": "reaction_10325949", "reactome": "R-XTR-2076419", "name": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10325677" ], "products": [ "species_742343", "species_10325691" ], "modifiers": [ [ "species_10325946", "catalyst" ] ], "additional_components": [ "Q0V9W0", "ENSXETT00000104077", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "ENSXETT00000011900" ] }, "reaction_10325593": { "compartment": "compartment_20699", "id": "reaction_10325593", "reactome": "R-XTR-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325590", "species_2022884" ], "products": [ "species_10325545", "species_2022890" ], "modifiers": [ [ "species_10325568", "catalyst" ] ], "additional_components": [ "A0A6I8R4L4", "ENSXETG00000039039", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8PYW4", "ENSXETG00000007104", "Q0V9W0", "ENSXETT00000104077", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "ENSXETG00000015804" ] }, "reaction_10319098": { "compartment": "compartment_20699", "id": "reaction_10319098", "reactome": "R-XTR-744231", "name": "SLC35D2 exchanges UDP-sugars for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744229", "species_735698" ], "products": [ "species_109402", "species_744234" ], "modifiers": [ [ "species_10319093", "catalyst" ] ], "additional_components": [ "species_744227", "species_162756", "species_744227", "species_162756", "ENSXETG00000041312" ] }, "reaction_10325767": { "compartment": "compartment_17963", "id": "reaction_10325767", "reactome": "R-XTR-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325693" ], "products": [ "species_10325765" ], "modifiers": [], "additional_components": [ "Q0V9W0", "ENSXETT00000104077", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8SBK0", "ENSXETG00000032333" ] }, "reaction_10325571": { "compartment": "compartment_20699", "id": "reaction_10325571", "reactome": "R-XTR-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10325545" ], "products": [ "species_742343", "species_10325564" ], "modifiers": [ [ "species_10325568", "catalyst" ] ], "additional_components": [ "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "Q0V9W0", "ENSXETT00000104077", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8R4L4", "ENSXETG00000039039", "ENSXETG00000015804" ] }, "reaction_10324079": { "compartment": "compartment_17938", "id": "reaction_10324079", "reactome": "R-XTR-1678660", "name": "HGSNAT oligomer acetylates Heparan sulfate chain(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090040", "species_76183" ], "products": [ "species_2090069", "species_76194" ], "modifiers": [ [ "species_10324076", "catalyst" ] ], "additional_components": [ "A0A6I8PYT1", "ENSXETG00000036665" ] }, "reaction_10325961": { "compartment": "compartment_161320", "id": "reaction_10325961", "reactome": "R-XTR-2090037", "name": "IDUA hydrolyses Heparan sulfate chain(6)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090055" ], "products": [ "species_2090070", "species_1678617" ], "modifiers": [ [ "species_10324111", "catalyst" ] ], "additional_components": [ "ENSXETG00000031913" ] }, "reaction_10325963": { "compartment": "compartment_17938", "id": "reaction_10325963", "reactome": "R-XTR-2090085", "name": "HGSNAT oligomer acetylates Heparan chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_2090045" ], "products": [ "species_2090053", "species_76194" ], "modifiers": [ [ "species_10324076", "catalyst" ] ], "additional_components": [ "A0A6I8PYT1", "ENSXETG00000036665" ] }, "reaction_10325601": { "compartment": "compartment_876", "id": "reaction_10325601", "reactome": "R-XTR-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324093" ], "products": [ "species_10323951" ], "modifiers": [], "additional_components": [ "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R5Q9", "ENSXETG00000035467", "Q0V9W0", "ENSXETT00000104077", "A0A6I8R4L4", "ENSXETG00000039039" ] }, "reaction_10324114": { "compartment": "compartment_161320", "id": "reaction_10324114", "reactome": "R-XTR-1678716", "name": "IDUA hydrolyses Heparan sulfate chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090033", "species_1605715" ], "products": [ "species_2090072", "species_1678617" ], "modifiers": [ [ "species_10324111", "catalyst" ] ], "additional_components": [ "ENSXETG00000031913" ] }, "reaction_10337912": { "compartment": "compartment_20699", "id": "reaction_10337912", "reactome": "R-XTR-9638064", "name": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10324414" ], "products": [ "species_10324442", "species_205687" ], "modifiers": [ [ "species_10324448", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8PV84", "ENSXETG00000015273", "F7DRX3", "ENSXETT00000049772", "CHEBI:29035" ] }, "reaction_10324451": { "compartment": "compartment_20699", "id": "reaction_10324451", "reactome": "R-XTR-1889955", "name": "B3GAT dimers transfer GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10324414" ], "products": [ "species_10324442", "species_205687" ], "modifiers": [ [ "species_10324448", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8PV84", "ENSXETG00000015273", "F7DRX3", "ENSXETT00000049772", "CHEBI:29035" ] }, "reaction_10324386": { "compartment": "compartment_20699", "id": "reaction_10324386", "reactome": "R-XTR-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324351", "species_742361" ], "products": [ "species_10324379", "species_205687" ], "modifiers": [ [ "species_10324383", "catalyst" ] ], "additional_components": [ "Q0V9W0", "ENSXETT00000104077", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R4L4", "ENSXETG00000039039", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8R4L4", "ENSXETG00000039039", "A0A6I8SBK0", "ENSXETG00000032333", "A4IIC2", "ENSXETT00000063928", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8PV84", "ENSXETG00000015273", "Q0V9W0", "ENSXETT00000104077", "ENSXETG00000006839" ] }, "reaction_10325917": { "compartment": "compartment_984", "id": "reaction_10325917", "reactome": "R-XTR-2046239", "name": "Extracellular KSPG translocates to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325889" ], "products": [ "species_10324223" ], "modifiers": [], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260" ] }, "reaction_10325932": { "compartment": "compartment_20699", "id": "reaction_10325932", "reactome": "R-XTR-2046285", "name": "The keratan chain can be capped by N-acetylneuraminic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_10325925" ], "products": [ "species_10325894", "species_727810" ], "modifiers": [ [ "species_10325929", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "ENSXETG00000026104" ] }, "reaction_10325774": { "compartment": "compartment_20699", "id": "reaction_10325774", "reactome": "R-XTR-2025723", "name": "B4GALTs transfer Gal to the N-glycan precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10325769" ], "products": [ "species_205687", "species_10325772" ], "modifiers": [ [ "species_10320782", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "A0A6I8QS90", "ENSXETG00000034513" ] }, "reaction_10325934": { "compartment": "compartment_20699", "id": "reaction_10325934", "reactome": "R-XTR-2046298", "name": "B4GALTs transfer Gal to a branch of keratan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325920", "species_735682" ], "products": [ "species_10325925", "species_205687" ], "modifiers": [ [ "species_10320782", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "A0A6I8QS90", "ENSXETG00000034513" ] }, "reaction_10325915": { "compartment": "compartment_20699", "id": "reaction_10325915", "reactome": "R-XTR-2046222", "name": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10325894" ], "products": [ "species_742343", "species_10325885" ], "modifiers": [ [ "species_10325912", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "A0A6I8Q6E3", "ENSXETG00000040380", "A0A6I8PUA8", "ENSXETG00000034141" ] }, "reaction_10325780": { "compartment": "compartment_20699", "id": "reaction_10325780", "reactome": "R-XTR-2025724", "name": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10325772" ], "products": [ "species_10325777", "species_205687" ], "modifiers": [ [ "species_10320403", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "ENSXETG00000040687" ] }, "reaction_10325891": { "compartment": "compartment_17963", "id": "reaction_10325891", "reactome": "R-XTR-2046180", "name": "KSPG is secreted from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325887" ], "products": [ "species_10325889" ], "modifiers": [], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260" ] }, "reaction_10325922": { "compartment": "compartment_20699", "id": "reaction_10325922", "reactome": "R-XTR-2046265", "name": "B4GALTs transfer Gal to the keratan chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325777", "species_735682" ], "products": [ "species_10325920", "species_205687" ], "modifiers": [ [ "species_10320782", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "A0A6I8QS90", "ENSXETG00000034513" ] }, "reaction_10326060": { "compartment": "compartment_161320", "id": "reaction_10326060", "reactome": "R-XTR-2160874", "name": "HYAL1 hydrolyses (HA)50", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2160864" ], "products": [ "species_2160866" ], "modifiers": [ [ "species_10324215", "catalyst" ] ], "additional_components": [ "species_2142867", "species_2142867", "ENSXETG00000040650" ] }, "reaction_10326088": { "compartment": "compartment_876", "id": "reaction_10326088", "reactome": "R-XTR-2160915", "name": "Receptor-mediated uptake of HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326064", "species_10326068", "species_2160848" ], "products": [ "species_10326070" ], "modifiers": [], "additional_components": [ "ENSXETG00000035220", "ENSXETT00000004761", "species_2142867", "species_2142867", "F7EIX5", "ENSXETT00000004761", "A0A6I8QK29", "ENSXETG00000035220" ] }, "reaction_10326086": { "compartment": "compartment_876", "id": "reaction_10326086", "reactome": "R-XTR-2160892", "name": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326083" ], "products": [ "species_2160894", "species_10326083" ], "modifiers": [ [ "species_10326083", "catalyst" ] ], "additional_components": [ "species_2142867", "F7EIX5", "ENSXETT00000004761", "A0A6I8QK29", "ENSXETG00000035220", "Q6DK70", "ENSXETT00000057366", "species_74112", "species_2142867", "species_2142867", "F7EIX5", "ENSXETT00000004761", "A0A6I8QK29", "ENSXETG00000035220", "Q6DK70", "ENSXETT00000057366", "species_74112", "species_2142867", "F7EIX5", "ENSXETT00000004761", "A0A6I8QK29", "ENSXETG00000035220", "Q6DK70", "ENSXETT00000057366", "species_74112" ] }, "reaction_10331295": { "compartment": "compartment_984", "id": "reaction_10331295", "reactome": "R-XTR-5693356", "name": "CEMIP hydrolyses HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2160848" ], "products": [ "species_5693343", "species_2160848" ], "modifiers": [ [ "species_10331292", "catalyst" ] ], "additional_components": [ "species_2142867", "species_2142867", "ENSXETG00000012981" ] }, "reaction_10326058": { "compartment": "compartment_876", "id": "reaction_10326058", "reactome": "R-XTR-2160851", "name": "HAS1,2,3 mediate the polymerisation of HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142867" ], "products": [ "species_2142896" ], "modifiers": [ [ "species_10326055", "catalyst" ] ], "additional_components": [ "species_2142867", "ENSXETG00000004083" ] }, "reaction_10325597": { "compartment": "compartment_17963", "id": "reaction_10325597", "reactome": "R-XTR-2022911", "name": "CSPG is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325595" ], "products": [ "species_10324884" ], "modifiers": [], "additional_components": [ "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928" ] }, "reaction_10324604": { "compartment": "compartment_20699", "id": "reaction_10324604", "reactome": "R-XTR-1971491", "name": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10324544" ], "products": [ "species_10324594", "species_205687" ], "modifiers": [ [ "species_10324598", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "ENSXETG00000030580" ] }, "reaction_10324796": { "compartment": "compartment_20699", "id": "reaction_10324796", "reactome": "R-XTR-2018682", "name": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10324555" ], "products": [ "species_742343", "species_10324789" ], "modifiers": [ [ "species_10324793", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "ENSXETG00000032713" ] }, "reaction_10324601": { "compartment": "compartment_20699", "id": "reaction_10324601", "reactome": "R-XTR-1971487", "name": "CHPF,CHSY3 transfer GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10324594" ], "products": [ "species_10324555", "species_205687" ], "modifiers": [ [ "species_10324598", "catalyst" ] ], "additional_components": [ "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "ENSXETG00000030580" ] }, "reaction_10324778": { "compartment": "compartment_20699", "id": "reaction_10324778", "reactome": "R-XTR-2018659", "name": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10324566" ], "products": [ "species_10324771", "species_742343" ], "modifiers": [ [ "species_10324775", "catalyst" ] ], "additional_components": [ "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "ENSXETT00000038652" ] }, "reaction_10337892": { "compartment": "compartment_20699", "id": "reaction_10337892", "reactome": "R-XTR-9632034", "name": "CHSY1 transfers GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10324544" ], "products": [ "species_10324594", "species_205687" ], "modifiers": [ [ "species_10337886", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "ENSXETG00000018744" ] }, "reaction_10324583": { "compartment": "compartment_20699", "id": "reaction_10324583", "reactome": "R-XTR-1971483", "name": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10324555" ], "products": [ "species_742343", "species_10324566" ], "modifiers": [ [ "species_10324580", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "Q28E26", "ENSXETT00000079954", "A0A6I8Q0S9", "ENSXETG00000001882", "A0A6I8PMV5", "ENSXETG00000027548" ] }, "reaction_10337889": { "compartment": "compartment_20699", "id": "reaction_10337889", "reactome": "R-XTR-9632033", "name": "CHSY1 transfers GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10324594" ], "products": [ "species_10324555", "species_205687" ], "modifiers": [ [ "species_10337886", "catalyst" ] ], "additional_components": [ "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "ENSXETG00000018744" ] }, "reaction_10324829": { "compartment": "compartment_20699", "id": "reaction_10324829", "reactome": "R-XTR-2022052", "name": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324798" ], "products": [ "species_10324822" ], "modifiers": [ [ "species_10324826", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "ENSXETT00000066016" ] }, "reaction_10324954": { "compartment": "compartment_17963", "id": "reaction_10324954", "reactome": "R-XTR-2022065", "name": "DSPGs are secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324952" ], "products": [ "species_10324858" ], "modifiers": [], "additional_components": [ "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928" ] }, "reaction_10324218": { "compartment": "compartment_161320", "id": "reaction_10324218", "reactome": "R-XTR-1793209", "name": "HYAL1 hydrolyses Chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065257" ], "products": [ "species_2065212" ], "modifiers": [ [ "species_10324215", "catalyst" ] ], "additional_components": [ "CHEBI:63512", "CHEBI:63513", "CHEBI:63515", "CHEBI:63511", "ENSXETG00000040650" ] }, "reaction_10324211": { "compartment": "compartment_161320", "id": "reaction_10324211", "reactome": "R-XTR-1793186", "name": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105025" ], "products": [ "species_2104993", "species_1678617" ], "modifiers": [ [ "species_10324111", "catalyst" ] ], "additional_components": [ "ENSXETG00000031913" ] }, "reaction_10324930": { "compartment": "compartment_984", "id": "reaction_10324930", "reactome": "R-XTR-2022056", "name": "DSPG and CSPG translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324884", "species_10324858" ], "products": [ "species_10324928", "species_10324910" ], "modifiers": [], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273" ] }, "reaction_10330365": { "compartment": "compartment_70101", "id": "reaction_10330365", "reactome": "R-XTR-5662471", "name": "SORD tetramer oxidizes xylitol to D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5660033", "species_29360" ], "products": [ "species_70106", "species_5661281", "species_73473" ], "modifiers": [ [ "species_10330204", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8PMG1", "ENSXETG00000023897" ] }, "reaction_10330362": { "compartment": "compartment_70101", "id": "reaction_10330362", "reactome": "R-XTR-5661256", "name": "AKR1A1 reduces D-glucuronate to L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_5661264", "species_29364" ], "products": [ "species_29366", "species_5661268" ], "modifiers": [ [ "species_10330359", "catalyst" ] ], "additional_components": [ "ENSXETT00000007570" ] }, "reaction_10311741": { "compartment": "compartment_70101", "id": "reaction_10311741", "reactome": "R-XTR-71334", "name": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29882" ], "products": [ "species_29512", "species_29878" ], "modifiers": [ [ "species_10311738", "catalyst" ] ], "additional_components": [ "A0A6I8SUP4", "ENSXETG00000025887" ] }, "reaction_10311732": { "compartment": "compartment_70101", "id": "reaction_10311732", "reactome": "R-XTR-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31467" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10311729", "catalyst" ] ], "additional_components": [ "ENSXETG00000038389" ] }, "reaction_10335154": { "compartment": "compartment_161320", "id": "reaction_10335154", "reactome": "R-XTR-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_1678743", "species_6799594" ], "modifiers": [ [ "species_10335151", "catalyst" ] ], "additional_components": [ "ENSXETG00000002247" ] }, "reaction_10337628": { "compartment": "compartment_70101", "id": "reaction_10337628", "reactome": "R-XTR-9033959", "name": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_9033793" ], "products": [ "species_205687", "species_9033802" ], "modifiers": [ [ "species_10337625", "catalyst" ] ], "additional_components": [ "A0A6I8SLE8", "ENSXETG00000038208", "CHEBI:29035" ] }, "reaction_10337694": { "compartment": "compartment_17963", "id": "reaction_10337694", "reactome": "R-XTR-9036987", "name": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9037036" ], "modifiers": [ [ "species_10337691", "catalyst" ] ], "additional_components": [ "ENSXETG00000041078" ] }, "reaction_10337646": { "compartment": "compartment_984", "id": "reaction_10337646", "reactome": "R-XTR-9034042", "name": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9034101", "species_9034046" ], "products": [ "species_417888", "species_9037066" ], "modifiers": [ [ "species_10337643", "catalyst" ] ], "additional_components": [ "A0A6I8SLE8", "ENSXETG00000038208", "CHEBI:29035" ] }, "reaction_10337653": { "compartment": "compartment_984", "id": "reaction_10337653", "reactome": "R-XTR-9034053", "name": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9034101", "species_9034065" ], "products": [ "species_417888", "species_9037067" ], "modifiers": [ [ "species_10337650", "catalyst" ] ], "additional_components": [ "CHEBI:29035", "A0A6I8SLE8", "ENSXETG00000038208" ] }, "reaction_10337639": { "compartment": "compartment_70101", "id": "reaction_10337639", "reactome": "R-XTR-9033961", "name": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_9033793" ], "products": [ "species_9033798", "species_205687" ], "modifiers": [ [ "species_10337636", "catalyst" ] ], "additional_components": [ "CHEBI:29035", "A0A6I8SLE8", "ENSXETG00000038208" ] }, "reaction_10337619": { "compartment": "compartment_17963", "id": "reaction_10337619", "reactome": "R-XTR-9033949", "name": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_205689", "species_9033793" ], "modifiers": [ [ "species_10337616", "catalyst" ] ], "additional_components": [ "ENSXETG00000041078" ] }, "reaction_10337740": { "compartment": "compartment_17963", "id": "reaction_10337740", "reactome": "R-XTR-9605600", "name": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_9033790" ], "products": [ "species_727810", "species_9605685" ], "modifiers": [ [ "species_10325929", "catalyst" ] ], "additional_components": [ "ENSXETG00000026104" ] }, "reaction_10337743": { "compartment": "compartment_17963", "id": "reaction_10337743", "reactome": "R-XTR-9605609", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605595", "species_205683" ], "products": [ "species_9605615", "species_205689" ], "modifiers": [ [ "species_10331319", "catalyst" ] ], "additional_components": [ "ENSXETG00000032714" ] }, "reaction_10337721": { "compartment": "compartment_17963", "id": "reaction_10337721", "reactome": "R-XTR-9603984", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9605593", "species_205689" ], "modifiers": [ [ "species_10337718", "catalyst" ] ], "additional_components": [ "A0A6I8PN52", "ENSXETG00000037458", "A0A6I8PQF9", "ENSXETG00000032714" ] }, "reaction_10337736": { "compartment": "compartment_17963", "id": "reaction_10337736", "reactome": "R-XTR-9603989", "name": "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9604808", "species_735682" ], "products": [ "species_205687", "species_9036984" ], "modifiers": [ [ "species_10337733", "catalyst" ] ], "additional_components": [ "A0A6I8PS91", "ENSXETG00000040256", "A0A6I8PVV6", "ENSXETG00000040256" ] }, "reaction_10337723": { "compartment": "compartment_17963", "id": "reaction_10337723", "reactome": "R-XTR-9603986", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9605607" ], "modifiers": [ [ "species_10331319", "catalyst" ] ], "additional_components": [ "ENSXETG00000032714" ] }, "reaction_10337749": { "compartment": "compartment_17963", "id": "reaction_10337749", "reactome": "R-XTR-9605682", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605685", "species_205683" ], "products": [ "species_9605661", "species_205689" ], "modifiers": [ [ "species_10331319", "catalyst" ] ], "additional_components": [ "ENSXETG00000032714" ] }, "reaction_10337700": { "compartment": "compartment_17963", "id": "reaction_10337700", "reactome": "R-XTR-9603983", "name": "FUT2 transfers Fuc to LeX to form LeY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605593", "species_205683" ], "products": [ "species_205689", "species_9605586" ], "modifiers": [ [ "species_10337691", "catalyst" ] ], "additional_components": [ "ENSXETG00000041078" ] }, "reaction_10337751": { "compartment": "compartment_17963", "id": "reaction_10337751", "reactome": "R-XTR-9605700", "name": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_9605685" ], "products": [ "species_205687", "species_9605718" ], "modifiers": [ [ "species_10335255", "catalyst" ] ], "additional_components": [ "ENSXETG00000033376" ] }, "reaction_10337745": { "compartment": "compartment_17963", "id": "reaction_10337745", "reactome": "R-XTR-9605644", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605649", "species_205683" ], "products": [ "species_205689", "species_9605651" ], "modifiers": [ [ "species_10331319", "catalyst" ] ], "additional_components": [ "ENSXETG00000032714" ] }, "reaction_10337698": { "compartment": "compartment_17963", "id": "reaction_10337698", "reactome": "R-XTR-9603982", "name": "FUT2 transfers Fuc to LeA to form LeB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605607", "species_205683" ], "products": [ "species_205689", "species_9605394" ], "modifiers": [ [ "species_10337691", "catalyst" ] ], "additional_components": [ "ENSXETG00000041078" ] }, "reaction_10322454": { "compartment": "compartment_5460", "id": "reaction_10322454", "reactome": "R-XTR-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113531", "species_10322452" ], "products": [ "species_10322436" ], "modifiers": [], "additional_components": [ "A0A6I8R145", "ENSXETG00000039175", "A0A6I8Q5L5", "ENSXETG00000038488", "Q6P633", "ENSXETT00000057208", "A0A6I8Q5L5", "ENSXETG00000038488", "Q6P633", "ENSXETT00000057208", "A0A6I8R145", "ENSXETG00000039175", "species_435347" ] }, "reaction_10322449": { "compartment": "compartment_5460", "id": "reaction_10322449", "reactome": "R-XTR-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379721", "species_10322436", "species_10322442" ], "products": [ "species_379697", "species_10322446", "species_10322444" ], "modifiers": [ [ "species_10322436", "catalyst" ], [ "species_10322442", "catalyst" ] ], "additional_components": [ "A0A6I8Q5L5", "ENSXETG00000038488", "Q6P633", "ENSXETT00000057208", "A0A6I8R145", "ENSXETG00000039175", "species_435347", "CHEBI:33738", "F7CAB2", "ENSXETT00000030454", "F7CAB2", "ENSXETT00000030454", "CHEBI:33737", "A0A6I8R145", "ENSXETG00000039175", "A0A6I8Q5L5", "ENSXETG00000038488", "Q6P633", "ENSXETT00000057208", "CHEBI:33739", "A0A6I8Q5L5", "ENSXETG00000038488", "Q6P633", "ENSXETT00000057208", "A0A6I8R145", "ENSXETG00000039175", "species_435347", "CHEBI:33738", "F7CAB2", "ENSXETT00000030454" ] }, "reaction_10336048": { "compartment": "compartment_5460", "id": "reaction_10336048", "reactome": "R-XTR-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336040", "species_10336030" ], "products": [ "species_10336042", "species_10336028" ], "modifiers": [ [ "species_10336046", "catalyst" ] ], "additional_components": [ "A0A6I8PNK1", "ENSXETG00000031871", "A0A6I8PY88", "ENSXETG00000030839", "Q6DJ11", "ENSXETT00000054920", "CHEBI:33739", "A0A6I8PNK1", "ENSXETG00000031871", "A0A6I8PY88", "ENSXETG00000030839", "CHEBI:49883", "ENSXETT00000054920", "ENSXETG00000026948" ] }, "reaction_10317263": { "compartment": "compartment_876", "id": "reaction_10317263", "reactome": "R-XTR-381713", "name": "Potassium voltage-gated channels close in reponse to PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317261" ], "products": [ "species_10317261" ], "modifiers": [], "additional_components": [ "A0A6I8PNT1", "ENSXETG00000032745", "A0A6I8PSS9", "ENSXETG00000015573", "A0A6I8PNT1", "ENSXETG00000032745", "A0A6I8PSS9", "ENSXETG00000015573" ] }, "reaction_10317251": { "compartment": "compartment_12045", "id": "reaction_10317251", "reactome": "R-XTR-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317243" ], "products": [ "species_10317249" ], "modifiers": [], "additional_components": [ "F6XEN8", "ENSXETT00000003958", "A0A6I8QV43", "ENSXETG00000005153", "species_114520", "A0A6I8QV43", "ENSXETG00000005153", "F6XEN8", "ENSXETT00000003958" ] }, "reaction_10317267": { "compartment": "compartment_70101", "id": "reaction_10317267", "reactome": "R-XTR-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10317265" ], "products": [ "species_29420", "species_10316760" ], "modifiers": [], "additional_components": [ "species_29420", "Q640R7", "ENSXETT00000104159", "Q640R7", "ENSXETT00000104159", "species_29438" ] }, "reaction_10335625": { "compartment": "compartment_70101", "id": "reaction_10335625", "reactome": "R-XTR-8862380", "name": "HSD17B13 binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331297", "species_8866926" ], "products": [ "species_10335623" ], "modifiers": [], "additional_components": [ "ENSXETT00000002941", "species_171126", "species_163579", "species_171142", "species_171126", "species_163579", "species_171142", "A8WGW3", "ENSXETT00000002941" ] }, "reaction_10335344": { "compartment": "compartment_12045", "id": "reaction_10335344", "reactome": "R-XTR-8857686", "name": "FITM1, FITM2 bind TAGs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549167", "species_10335340" ], "products": [ "species_10335342" ], "modifiers": [], "additional_components": [ "ENSXETG00000001773", "A0JP80", "ENSXETG00000001773", "species_171126" ] }, "reaction_10331439": { "compartment": "compartment_12045", "id": "reaction_10331439", "reactome": "R-XTR-5696119", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_5696122", "species_29368" ], "products": [ "species_29356", "species_1497857", "species_76116", "species_5696116" ], "modifiers": [ [ "species_10331436", "catalyst" ] ], "additional_components": [ "ENSXETG00000005052" ] }, "reaction_10333674": { "compartment": "compartment_12045", "id": "reaction_10333674", "reactome": "R-XTR-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76103", "species_76194" ], "modifiers": [ [ "species_10333671", "catalyst" ] ], "additional_components": [ "Q5M8H5", "ENSXETT00000008697", "Q28C88", "ENSXETG00000002935" ] }, "reaction_10319045": { "compartment": "compartment_70101", "id": "reaction_10319045", "reactome": "R-XTR-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10319042", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10323897": { "compartment": "compartment_876", "id": "reaction_10323897", "reactome": "R-XTR-1606583", "name": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429807" ], "products": [ "species_1606609", "species_1861754" ], "modifiers": [ [ "species_10323894", "catalyst" ] ], "additional_components": [] }, "reaction_10323915": { "compartment": "compartment_20699", "id": "reaction_10323915", "reactome": "R-XTR-1638104", "name": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744227", "species_428270" ], "products": [ "species_1660674", "species_205687" ], "modifiers": [ [ "species_10323912", "catalyst" ] ], "additional_components": [ "ENSXETT00000084396" ] }, "reaction_10329573": { "compartment": "compartment_70101", "id": "reaction_10329573", "reactome": "R-XTR-5339535", "name": "GLTPD1 transports C1P from plasma membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1638840" ], "products": [ "species_5339515" ], "modifiers": [ [ "species_10329570", "catalyst" ] ], "additional_components": [ "ENSXETT00000024361" ] }, "reaction_10323888": { "compartment": "compartment_161320", "id": "reaction_10323888", "reactome": "R-XTR-1606564", "name": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1606573" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10323885", "catalyst" ] ], "additional_components": [ "ENSXETG00000016608" ] }, "reaction_10323922": { "compartment": "compartment_876", "id": "reaction_10323922", "reactome": "R-XTR-1638845", "name": "CERK phosphorylates CERA to form C1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_113592" ], "products": [ "species_29370", "species_1638840" ], "modifiers": [ [ "species_10323919", "catalyst" ] ], "additional_components": [ "ENSXETG00000030525" ] }, "reaction_10318077": { "compartment": "compartment_70101", "id": "reaction_10318077", "reactome": "R-XTR-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_428126", "species_29368" ], "products": [ "species_428218", "species_29356", "species_428256" ], "modifiers": [ [ "species_10318074", "catalyst" ] ], "additional_components": [ "species_73473", "species_113600", "species_29360", "species_113563", "ENSXETT00000040228" ] }, "reaction_10318094": { "compartment": "compartment_70101", "id": "reaction_10318094", "reactome": "R-XTR-428701", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10318088", "catalyst" ] ], "additional_components": [ "ENSXETG00000030642" ] }, "reaction_10318091": { "compartment": "compartment_70101", "id": "reaction_10318091", "reactome": "R-XTR-428664", "name": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428275" ], "products": [ "species_29372", "species_428694" ], "modifiers": [ [ "species_10318088", "catalyst" ] ], "additional_components": [ "ENSXETG00000030642" ] }, "reaction_10336999": { "compartment": "compartment_12045", "id": "reaction_10336999", "reactome": "R-XTR-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959490", "species_8959486" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10336996", "catalyst" ] ], "additional_components": [ "ENSXETT00000042961" ] }, "reaction_10318070": { "compartment": "compartment_70101", "id": "reaction_10318070", "reactome": "R-XTR-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_428163" ], "products": [ "species_428126", "species_76194" ], "modifiers": [ [ "species_10318067", "catalyst" ] ], "additional_components": [ "ENSXETT00000029263" ] }, "reaction_10331218": { "compartment": "compartment_12045", "id": "reaction_10331218", "reactome": "R-XTR-5692261", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428671", "species_29360" ], "products": [ "species_70106", "species_3632881", "species_73473" ], "modifiers": [ [ "species_10331215", "catalyst" ] ], "additional_components": [ "F6X8Y6", "ENSXETT00000029530" ] }, "reaction_10314156": { "compartment": "compartment_70101", "id": "reaction_10314156", "reactome": "R-XTR-191303", "name": "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191409", "species_191362" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10314153", "catalyst" ] ], "additional_components": [ "species_109496", "A0A6I8QKN8", "ENSXETG00000040625" ] }, "reaction_10314159": { "compartment": "compartment_70101", "id": "reaction_10314159", "reactome": "R-XTR-191322", "name": "Addition of isopentenyl pyrophosphate to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191324", "species_191362" ], "products": [ "species_111294", "species_191409" ], "modifiers": [ [ "species_10314153", "catalyst" ] ], "additional_components": [ "species_109496", "A0A6I8QKN8", "ENSXETG00000040625" ] }, "reaction_10314175": { "compartment": "compartment_70101", "id": "reaction_10314175", "reactome": "R-XTR-191366", "name": "Squalene 2,3-epoxide cyclizes, forming lanosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191309" ], "products": [ "species_194634" ], "modifiers": [ [ "species_10314172", "catalyst" ] ], "additional_components": [ "ENSXETT00000043201" ] }, "reaction_10314168": { "compartment": "compartment_70101", "id": "reaction_10314168", "reactome": "R-XTR-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374", "species_70106", "species_29364" ], "products": [ "species_29366", "species_76194", "species_191424" ], "modifiers": [ [ "species_10314165", "catalyst" ] ], "additional_components": [ "A0A6I8REP9", "ENSXETG00000005084" ] }, "reaction_10314315": { "compartment": "compartment_13231", "id": "reaction_10314315", "reactome": "R-XTR-194674", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194681", "species_194725", "species_194688" ], "products": [ "species_194668", "species_194704" ], "modifiers": [ [ "species_10314312", "catalyst" ] ], "additional_components": [ "ENSXETG00000034786" ] }, "reaction_10329482": { "compartment": "compartment_17957", "id": "reaction_10329482", "reactome": "R-XTR-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10329479", "catalyst" ] ], "additional_components": [ "ENSXETT00000055609" ] }, "reaction_10314344": { "compartment": "compartment_70101", "id": "reaction_10314344", "reactome": "R-XTR-196417", "name": "Reduction of desmosterol to cholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_196420", "species_29364" ], "products": [ "species_193384", "species_29366" ], "modifiers": [ [ "species_10314341", "catalyst" ] ], "additional_components": [ "ENSXETG00000020010" ] }, "reaction_10314337": { "compartment": "compartment_70101", "id": "reaction_10314337", "reactome": "R-XTR-196402", "name": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_195655", "species_29364" ], "products": [ "species_29366", "species_196420" ], "modifiers": [ [ "species_10314334", "catalyst" ] ], "additional_components": [ "ENSXETG00000008945" ] }, "reaction_10314322": { "compartment": "compartment_70101", "id": "reaction_10314322", "reactome": "R-XTR-195664", "name": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_195691", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_195655" ], "modifiers": [ [ "species_10314319", "catalyst" ] ], "additional_components": [ "ENSXETG00000040073" ] }, "reaction_10336886": { "compartment": "compartment_70101", "id": "reaction_10336886", "reactome": "R-XTR-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_191265" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10336883", "catalyst" ] ], "additional_components": [ "ENSXETT00000041334" ] }, "reaction_10335903": { "compartment": "compartment_70101", "id": "reaction_10335903", "reactome": "R-XTR-8873850", "name": "STARD5 binds DCA, LCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_10335899", "species_5357505" ], "products": [ "species_10335901" ], "modifiers": [], "additional_components": [ "ENSXETG00000030995", "species_5357505", "A0A6I8PZC4", "ENSXETG00000030995", "species_176655" ] }, "reaction_10313015": { "compartment": "compartment_70101", "id": "reaction_10313015", "reactome": "R-XTR-159431", "name": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194073", "species_194069" ], "products": [ "species_193416", "species_76194" ], "modifiers": [ [ "species_10313012", "catalyst" ] ], "additional_components": [ "species_192356", "species_193472", "species_159549", "CHEBI:15891", "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:28865", "ENSXETT00000000095" ] }, "reaction_10335837": { "compartment": "compartment_70101", "id": "reaction_10335837", "reactome": "R-XTR-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10335834", "catalyst" ] ], "additional_components": [ "Q0IJ05", "ENSXETG00000002831", "A0A6I8SCX9", "ENSXETG00000015011" ] }, "reaction_10314190": { "compartment": "compartment_5460", "id": "reaction_10314190", "reactome": "R-XTR-191999", "name": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_192078", "species_113529", "species_113600" ], "products": [ "species_192201", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314213": { "compartment": "compartment_5460", "id": "reaction_10314213", "reactome": "R-XTR-192042", "name": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192201", "species_113563" ], "products": [ "species_113529", "species_191968", "species_113600" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314261": { "compartment": "compartment_17951", "id": "reaction_10314261", "reactome": "R-XTR-193491", "name": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193463", "species_193472" ], "products": [ "species_193453", "species_193514" ], "modifiers": [ [ "species_10314228", "catalyst" ] ], "additional_components": [ "species_159549", "CHEBI:15891", "CHEBI:36274", "CHEBI:16525", "ENSXETT00000000095" ] }, "reaction_10314263": { "compartment": "compartment_5460", "id": "reaction_10314263", "reactome": "R-XTR-193497", "name": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_193387" ], "products": [ "species_193435", "species_113529", "species_113600" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314215": { "compartment": "compartment_5460", "id": "reaction_10314215", "reactome": "R-XTR-192054", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_191968", "species_113600" ], "products": [ "species_113563", "species_192161", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314231": { "compartment": "compartment_17951", "id": "reaction_10314231", "reactome": "R-XTR-192312", "name": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192356", "species_193463" ], "products": [ "species_193404", "species_193514" ], "modifiers": [ [ "species_10314228", "catalyst" ] ], "additional_components": [ "species_159549", "CHEBI:15891", "CHEBI:17687", "CHEBI:28865", "ENSXETT00000000095" ] }, "reaction_10314257": { "compartment": "compartment_5460", "id": "reaction_10314257", "reactome": "R-XTR-193393", "name": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193436", "species_113533", "species_113529", "species_113600" ], "products": [ "species_113563", "species_193387", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314211": { "compartment": "compartment_70101", "id": "reaction_10314211", "reactome": "R-XTR-192036", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192064" ], "products": [ "species_29366", "species_192087" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10314259": { "compartment": "compartment_5460", "id": "reaction_10314259", "reactome": "R-XTR-193460", "name": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_193435", "species_113529", "species_113600" ], "products": [ "species_113563", "species_193440", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314226": { "compartment": "compartment_70101", "id": "reaction_10314226", "reactome": "R-XTR-192160", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191980", "species_70106", "species_29364" ], "products": [ "species_192030", "species_29366" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10335848": { "compartment": "compartment_70101", "id": "reaction_10335848", "reactome": "R-XTR-8868402", "name": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399", "species_1806217" ], "products": [ "species_8868393", "species_1806234" ], "modifiers": [ [ "species_10335845", "catalyst" ] ], "additional_components": [ "ENSXETG00000020714" ] }, "reaction_10314269": { "compartment": "compartment_5460", "id": "reaction_10314269", "reactome": "R-XTR-193719", "name": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193708", "species_113533", "species_113529", "species_113600" ], "products": [ "species_113563", "species_193716", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314271": { "compartment": "compartment_5460", "id": "reaction_10314271", "reactome": "R-XTR-193737", "name": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_193716", "species_113600" ], "products": [ "species_193757", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314281": { "compartment": "compartment_5460", "id": "reaction_10314281", "reactome": "R-XTR-193792", "name": "CYP27A1 27-hydroxylates 5-CHOL3,7,24(s)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_193720", "species_113529", "species_113600" ], "products": [ "species_193708", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314267": { "compartment": "compartment_5460", "id": "reaction_10314267", "reactome": "R-XTR-193713", "name": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_193785", "species_113529", "species_113600" ], "products": [ "species_113563", "species_193747", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314277": { "compartment": "compartment_70101", "id": "reaction_10314277", "reactome": "R-XTR-193781", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193707", "species_29364" ], "products": [ "species_29366", "species_193728" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10314279": { "compartment": "compartment_5460", "id": "reaction_10314279", "reactome": "R-XTR-193787", "name": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_193777", "species_113600" ], "products": [ "species_113563", "species_193782", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314273": { "compartment": "compartment_70101", "id": "reaction_10314273", "reactome": "R-XTR-193758", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193760" ], "products": [ "species_29366", "species_213285" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10314275": { "compartment": "compartment_5460", "id": "reaction_10314275", "reactome": "R-XTR-193780", "name": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_193782", "species_113600" ], "products": [ "species_193785", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314285": { "compartment": "compartment_70101", "id": "reaction_10314285", "reactome": "R-XTR-193841", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193830" ], "products": [ "species_29366", "species_193842" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10314283": { "compartment": "compartment_70101", "id": "reaction_10314283", "reactome": "R-XTR-193800", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193829", "species_29364" ], "products": [ "species_29366", "species_193843" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10331300": { "compartment": "compartment_70101", "id": "reaction_10331300", "reactome": "R-XTR-5693390", "name": "HSD17B11 dehydrogenates EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193132", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10331297", "catalyst" ] ], "additional_components": [ "ENSXETT00000002941" ] }, "reaction_10334610": { "compartment": "compartment_70101", "id": "reaction_10334610", "reactome": "R-XTR-6810594", "name": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176619", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10334607", "catalyst" ] ], "additional_components": [ "A0A6I8S4B9", "ENSXETG00000035086" ] }, "reaction_10314330": { "compartment": "compartment_70616", "id": "reaction_10314330", "reactome": "R-XTR-196086", "name": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314328" ], "products": [ "species_10314326", "species_193156" ], "modifiers": [], "additional_components": [ "species_216762", "F7C998", "ENSXETT00000006725", "ENSXETT00000006725" ] }, "reaction_10338216": { "compartment": "compartment_70101", "id": "reaction_10338216", "reactome": "R-XTR-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10328552", "catalyst" ] ], "additional_components": [ "ENSXETG00000021063" ] }, "reaction_10338213": { "compartment": "compartment_70101", "id": "reaction_10338213", "reactome": "R-XTR-9705713", "name": "SRD5A2 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10338210", "catalyst" ] ], "additional_components": [ "ENSXETG00000025082" ] }, "reaction_10314308": { "compartment": "compartment_17957", "id": "reaction_10314308", "reactome": "R-XTR-194023", "name": "HSD11B2,HSD11B1 dimer oxidise CORT to COR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193977", "species_29366" ], "products": [ "species_70106", "species_29364", "species_194035" ], "modifiers": [ [ "species_10314305", "catalyst" ] ], "additional_components": [ "A4IGM4", "ENSXETT00000031363" ] }, "reaction_10322500": { "compartment": "compartment_984", "id": "reaction_10322500", "reactome": "R-XTR-1449687", "name": "Corticosteroids bind to CBG in blood", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1449707", "species_10322496" ], "products": [ "species_10322498" ], "modifiers": [], "additional_components": [ "species_193982", "CHEBI:17026", "species_194011", "species_193988", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350", "A0A6I8QL92", "ENSXETG00000039008", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350", "A0A6I8QL92", "ENSXETG00000039008", "species_193982", "CHEBI:17026", "species_194011", "species_193988" ] }, "reaction_10319038": { "compartment": "compartment_70101", "id": "reaction_10319038", "reactome": "R-XTR-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_548836", "species_29366" ], "modifiers": [ [ "species_10319035", "catalyst" ] ], "additional_components": [ "ENSXETT00000048094" ] }, "reaction_10315643": { "compartment": "compartment_70101", "id": "reaction_10315643", "reactome": "R-XTR-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3632881", "species_76194" ], "products": [ "species_111294", "species_29356", "species_200993", "species_76577" ], "modifiers": [ [ "species_10315640", "catalyst" ] ], "additional_components": [ "ENSXETG00000016588" ] }, "reaction_10319031": { "compartment": "compartment_70101", "id": "reaction_10319031", "reactome": "R-XTR-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_113528", "species_548812", "species_76194" ], "modifiers": [ [ "species_10319028", "catalyst" ] ], "additional_components": [ "ENSXETG00000035907" ] }, "reaction_10319024": { "compartment": "compartment_70101", "id": "reaction_10319024", "reactome": "R-XTR-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_29508" ], "products": [ "species_113528", "species_548816", "species_76194" ], "modifiers": [ [ "species_10319021", "catalyst" ] ], "additional_components": [ "ENSXETT00000034904" ] }, "reaction_10330576": { "compartment": "compartment_12045", "id": "reaction_10330576", "reactome": "R-XTR-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_29356", "species_5676634" ], "modifiers": [ [ "species_10330573", "catalyst" ] ], "additional_components": [ "A0A6I8T2J8", "ENSXETG00000040752" ] }, "reaction_10334601": { "compartment": "compartment_17951", "id": "reaction_10334601", "reactome": "R-XTR-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10334598", "catalyst" ] ], "additional_components": [ "ENSXETT00000054418" ] }, "reaction_10334696": { "compartment": "compartment_17947", "id": "reaction_10334696", "reactome": "R-XTR-8848247", "name": "ACBD4,5 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690520", "species_10334692" ], "products": [ "species_10334694" ], "modifiers": [], "additional_components": [ "CHEBI:33184", "CHEBI:61907", "Q640U0", "ENSXETT00000040674", "Q640U0", "ENSXETT00000040674", "CHEBI:33184", "CHEBI:61907" ] }, "reaction_10317404": { "compartment": "compartment_17947", "id": "reaction_10317404", "reactome": "R-XTR-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10317281", "catalyst" ] ], "additional_components": [ "A0A6I8Q353", "ENSXETG00000007705" ] }, "reaction_10330926": { "compartment": "compartment_17951", "id": "reaction_10330926", "reactome": "R-XTR-5690042", "name": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690520", "species_141343" ], "products": [ "species_5690539", "species_193514" ], "modifiers": [ [ "species_10330921", "catalyst" ] ], "additional_components": [ "CHEBI:33184", "CHEBI:61907", "CHEBI:59554", "species_30495", "ENSXETT00000000095" ] }, "reaction_10334585": { "compartment": "compartment_17951", "id": "reaction_10334585", "reactome": "R-XTR-6809808", "name": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6809801" ], "products": [ "species_6809800" ], "modifiers": [ [ "species_10334582", "catalyst" ] ], "additional_components": [ "A0A6I8RBB6", "ENSXETG00000032831" ] }, "reaction_10332329": { "compartment": "compartment_17951", "id": "reaction_10332329", "reactome": "R-XTR-6786720", "name": "DECR2 reduces LCtE-CoA to t3enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193465", "species_6786723", "species_113602" ], "products": [ "species_6786715", "species_389556" ], "modifiers": [ [ "species_10332326", "catalyst" ] ], "additional_components": [ "ENSXETT00000022727" ] }, "reaction_10334554": { "compartment": "compartment_17951", "id": "reaction_10334554", "reactome": "R-XTR-6809264", "name": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10334548", "catalyst" ] ], "additional_components": [ "ENSXETT00000023381" ] }, "reaction_10334551": { "compartment": "compartment_17951", "id": "reaction_10334551", "reactome": "R-XTR-6809263", "name": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_390249" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10334548", "catalyst" ] ], "additional_components": [ "ENSXETT00000023381" ] }, "reaction_10320834": { "compartment": "compartment_17951", "id": "reaction_10320834", "reactome": "R-XTR-977317", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977323" ], "products": [ "species_353123", "species_389536" ], "modifiers": [ [ "species_10320831", "catalyst" ] ], "additional_components": [ "ENSXETG00000013233" ] }, "reaction_10317365": { "compartment": "compartment_17951", "id": "reaction_10317365", "reactome": "R-XTR-389609", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389636", "species_192307" ], "products": [ "species_193465", "species_6811612", "species_192305" ], "modifiers": [ [ "species_10317362", "catalyst" ] ], "additional_components": [ "F6X8Y6", "ENSXETT00000029530" ] }, "reaction_10317391": { "compartment": "compartment_17951", "id": "reaction_10317391", "reactome": "R-XTR-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10317388", "catalyst" ] ], "additional_components": [ "species_113596", "A0A6I8PRN9", "ENSXETG00000031495" ] }, "reaction_10325882": { "compartment": "compartment_12045", "id": "reaction_10325882", "reactome": "R-XTR-2046100", "name": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046059", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046057", "species_162743", "species_159751" ], "modifiers": [ [ "species_10319021", "catalyst" ] ], "additional_components": [ "ENSXETT00000034904" ] }, "reaction_10325876": { "compartment": "compartment_17957", "id": "reaction_10325876", "reactome": "R-XTR-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046051", "species_162743", "species_159751" ], "modifiers": [ [ "species_10319021", "catalyst" ] ], "additional_components": [ "ENSXETT00000034904" ] }, "reaction_10325874": { "compartment": "compartment_17957", "id": "reaction_10325874", "reactome": "R-XTR-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_426639", "species_211606", "species_2046047" ], "modifiers": [ [ "species_10317279", "catalyst" ] ], "additional_components": [ "ENSXETG00000007705" ] }, "reaction_10326111": { "compartment": "compartment_12045", "id": "reaction_10326111", "reactome": "R-XTR-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2142739" ], "modifiers": [ [ "species_10326101", "catalyst" ] ], "additional_components": [ "A0A6I8SJ30", "ENSXETG00000038590", "A4IGV4", "ENSXETT00000061279" ] }, "reaction_10326116": { "compartment": "compartment_12045", "id": "reaction_10326116", "reactome": "R-XTR-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_2161753", "species_29366" ], "modifiers": [ [ "species_10326113", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "A0A6I8SJ30", "ENSXETG00000038590", "A0A6I8PUP3", "ENSXETG00000033706", "A4IGV4", "ENSXETT00000061279" ] }, "reaction_10326136": { "compartment": "compartment_70101", "id": "reaction_10326136", "reactome": "R-XTR-2161950", "name": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2142790" ], "modifiers": [ [ "species_10326133", "catalyst" ] ], "additional_components": [ "species_435347", "A0A6I8QVI1", "ENSXETG00000018683", "A0A6I8R9T5", "ENSXETG00000000004" ] }, "reaction_10336762": { "compartment": "compartment_70101", "id": "reaction_10336762", "reactome": "R-XTR-8942208", "name": "ALOXE3 isomerises 12R-HpETE to HXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142790" ], "products": [ "species_8942209" ], "modifiers": [ [ "species_10336759", "catalyst" ] ], "additional_components": [ "A0A6I8R9T5", "ENSXETG00000000004", "A0A6I8QVI1", "ENSXETG00000018683" ] }, "reaction_10331492": { "compartment": "compartment_12045", "id": "reaction_10331492", "reactome": "R-XTR-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192172", "species_5696426" ], "products": [ "species_5696412", "species_162743" ], "modifiers": [ [ "species_10331489", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10326094": { "compartment": "compartment_70101", "id": "reaction_10326094", "reactome": "R-XTR-2161614", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_879629" ], "products": [ "species_29366", "species_2142710" ], "modifiers": [ [ "species_10314206", "catalyst" ] ], "additional_components": [ "A0A6I8R8Y6", "ENSXETG00000040684", "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10326091": { "compartment": "compartment_70101", "id": "reaction_10326091", "reactome": "R-XTR-2161549", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_265283", "species_29364" ], "products": [ "species_29366", "species_879535" ], "modifiers": [ [ "species_10314206", "catalyst" ] ], "additional_components": [ "A0A6I8R8Y6", "ENSXETG00000040684", "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10326099": { "compartment": "compartment_70101", "id": "reaction_10326099", "reactome": "R-XTR-2161701", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_879629" ], "modifiers": [ [ "species_10326096", "catalyst" ] ], "additional_components": [ "F6SJ37", "ENSXETT00000045440", "species_1247892" ] }, "reaction_10326143": { "compartment": "compartment_70101", "id": "reaction_10326143", "reactome": "R-XTR-2162002", "name": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2142718" ], "modifiers": [ [ "species_10326140", "catalyst" ] ], "additional_components": [ "A0A6I8QVI1", "ENSXETG00000018683", "species_435347" ] }, "reaction_10312563": { "compartment": "compartment_12045", "id": "reaction_10312563", "reactome": "R-XTR-111883", "name": "Hydrolysis of phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_140356", "species_428981" ], "modifiers": [ [ "species_10312558", "catalyst" ] ], "additional_components": [ "B1WAZ6", "ENSXETT00000066288", "species_74112", "species_426925" ] }, "reaction_10335800": { "compartment": "compartment_70101", "id": "reaction_10335800", "reactome": "R-XTR-8866941", "name": "MID1IP1 binds THRSP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335794", "species_10335796" ], "products": [ "species_10335798" ], "modifiers": [], "additional_components": [ "ENSXETT00000087898", "ENSXETT00000087898", "Q6P8B2", "ENSXETT00000087898" ] }, "reaction_10315632": { "compartment": "compartment_70616", "id": "reaction_10315632", "reactome": "R-XTR-200410", "name": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_201050" ], "products": [ "species_201023", "species_77281" ], "modifiers": [ [ "species_10315629", "catalyst" ] ], "additional_components": [ "ENSXETT00000017686" ] }, "reaction_10330939": { "compartment": "compartment_70101", "id": "reaction_10330939", "reactome": "R-XTR-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5690044" ], "products": [ "species_5690064", "species_76194" ], "modifiers": [ [ "species_10330936", "catalyst" ] ], "additional_components": [ "CHEBI:61907", "CHEBI:33184", "CHEBI:59554", "species_30495", "Q6DER5", "ENSXETT00000054972", "F6UBG9", "ENSXETT00000000095" ] }, "reaction_10330950": { "compartment": "compartment_5460", "id": "reaction_10330950", "reactome": "R-XTR-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10330947", "catalyst" ] ], "additional_components": [ "CHEBI:33184", "CHEBI:61907", "species_30495", "CHEBI:59554", "F6UBG9", "ENSXETT00000000095", "A0A6I8RQ71", "ENSXETG00000036041" ] }, "reaction_10336900": { "compartment": "compartment_5460", "id": "reaction_10336900", "reactome": "R-XTR-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113529", "species_113600" ], "products": [ "species_77308", "species_113563" ], "modifiers": [ [ "species_10336897", "catalyst" ] ], "additional_components": [ "Q28GQ2", "ENSXETT00000031439" ] }, "reaction_10324062": { "compartment": "compartment_876", "id": "reaction_10324062", "reactome": "R-XTR-1676164", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10324057", "catalyst" ] ], "additional_components": [ "ENSXETG00000019407" ] }, "reaction_10324025": { "compartment": "compartment_876", "id": "reaction_10324025", "reactome": "R-XTR-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10324015", "catalyst" ] ], "additional_components": [ "ENSXETG00000009899" ] }, "reaction_10323994": { "compartment": "compartment_876", "id": "reaction_10323994", "reactome": "R-XTR-1675780", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_392417" ], "modifiers": [ [ "species_10323991", "catalyst" ] ], "additional_components": [ "Q28G26", "ENSXETG00000000962", "Q505I0", "ENSXETG00000013516" ] }, "reaction_10324053": { "compartment": "compartment_876", "id": "reaction_10324053", "reactome": "R-XTR-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10323969", "catalyst" ] ], "additional_components": [ "ENSXETT00000042073" ] }, "reaction_10324020": { "compartment": "compartment_876", "id": "reaction_10324020", "reactome": "R-XTR-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10324015", "catalyst" ] ], "additional_components": [ "ENSXETG00000009899" ] }, "reaction_10324048": { "compartment": "compartment_876", "id": "reaction_10324048", "reactome": "R-XTR-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10312068", "catalyst" ] ], "additional_components": [ "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252" ] }, "reaction_10323981": { "compartment": "compartment_876", "id": "reaction_10323981", "reactome": "R-XTR-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806240", "species_113592" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10323978", "catalyst" ] ], "additional_components": [ "Q6GL14", "ENSXETG00000006229" ] }, "reaction_10324043": { "compartment": "compartment_876", "id": "reaction_10324043", "reactome": "R-XTR-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10323969", "catalyst" ] ], "additional_components": [ "ENSXETT00000042073" ] }, "reaction_10324037": { "compartment": "compartment_876", "id": "reaction_10324037", "reactome": "R-XTR-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10312068", "catalyst" ] ], "additional_components": [ "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252" ] }, "reaction_10323972": { "compartment": "compartment_876", "id": "reaction_10323972", "reactome": "R-XTR-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10323969", "catalyst" ] ], "additional_components": [ "ENSXETT00000042073" ] }, "reaction_10324070": { "compartment": "compartment_876", "id": "reaction_10324070", "reactome": "R-XTR-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10324031", "catalyst" ] ], "additional_components": [ "A0A6I8QJY3", "ENSXETG00000016428", "A0A6I8RPT3", "ENSXETG00000009899" ] }, "reaction_10324065": { "compartment": "compartment_876", "id": "reaction_10324065", "reactome": "R-XTR-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10324015", "catalyst" ] ], "additional_components": [ "ENSXETG00000009899" ] }, "reaction_10324034": { "compartment": "compartment_876", "id": "reaction_10324034", "reactome": "R-XTR-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10324031", "catalyst" ] ], "additional_components": [ "A0A6I8QJY3", "ENSXETG00000016428", "A0A6I8RPT3", "ENSXETG00000009899" ] }, "reaction_10324045": { "compartment": "compartment_171062", "id": "reaction_10324045", "reactome": "R-XTR-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806205" ], "products": [ "species_29372", "species_1806259" ], "modifiers": [ [ "species_10323998", "catalyst" ] ], "additional_components": [ "ENSXETT00000011460" ] }, "reaction_10324060": { "compartment": "compartment_171062", "id": "reaction_10324060", "reactome": "R-XTR-1676162", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806238" ], "products": [ "species_29372", "species_1806200" ], "modifiers": [ [ "species_10324057", "catalyst" ] ], "additional_components": [ "ENSXETG00000019407" ] }, "reaction_10324022": { "compartment": "compartment_171062", "id": "reaction_10324022", "reactome": "R-XTR-1675974", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_1806180", "species_29370" ], "modifiers": [ [ "species_10323991", "catalyst" ] ], "additional_components": [ "Q28G26", "ENSXETG00000000962", "Q505I0", "ENSXETG00000013516" ] }, "reaction_10324050": { "compartment": "compartment_171062", "id": "reaction_10324050", "reactome": "R-XTR-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10323998", "catalyst" ] ], "additional_components": [ "ENSXETT00000011460" ] }, "reaction_10334562": { "compartment": "compartment_70101", "id": "reaction_10334562", "reactome": "R-XTR-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334558", "species_10323998" ], "products": [ "species_10334560" ], "modifiers": [], "additional_components": [ "ENSXETG00000015585", "ENSXETT00000011460", "F6VED7", "ENSXETT00000011460", "A0A6I8R2K2", "ENSXETG00000015585" ] }, "reaction_10334573": { "compartment": "compartment_70101", "id": "reaction_10334573", "reactome": "R-XTR-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5676030" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10334568", "catalyst" ] ], "additional_components": [ "F6VED7", "ENSXETT00000011460", "A0A6I8Q167", "ENSXETG00000023079" ] }, "reaction_10334570": { "compartment": "compartment_70101", "id": "reaction_10334570", "reactome": "R-XTR-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334566", "species_10323998" ], "products": [ "species_10334568" ], "modifiers": [], "additional_components": [ "ENSXETG00000023079", "ENSXETT00000011460", "F6VED7", "ENSXETT00000011460", "A0A6I8Q167", "ENSXETG00000023079" ] }, "reaction_10324004": { "compartment": "compartment_12045", "id": "reaction_10324004", "reactome": "R-XTR-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10323989", "catalyst" ] ], "additional_components": [ "ENSXETG00000000962" ] }, "reaction_10334576": { "compartment": "compartment_70101", "id": "reaction_10334576", "reactome": "R-XTR-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6809774" ], "products": [ "species_29372", "species_422529" ], "modifiers": [ [ "species_10334568", "catalyst" ] ], "additional_components": [ "F6VED7", "ENSXETT00000011460", "A0A6I8Q167", "ENSXETG00000023079" ] }, "reaction_10324011": { "compartment": "compartment_20699", "id": "reaction_10324011", "reactome": "R-XTR-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_29372", "species_1806217" ], "modifiers": [ [ "species_10324008", "catalyst" ] ], "additional_components": [ "ENSXETG00000038322" ] }, "reaction_10324067": { "compartment": "compartment_20699", "id": "reaction_10324067", "reactome": "R-XTR-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10323991", "catalyst" ] ], "additional_components": [ "Q28G26", "ENSXETG00000000962", "Q505I0", "ENSXETG00000013516" ] }, "reaction_10335920": { "compartment": "compartment_437051", "id": "reaction_10335920", "reactome": "R-XTR-8874470", "name": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8874484" ], "products": [ "species_8874460" ], "modifiers": [ [ "species_10335917", "catalyst" ] ], "additional_components": [ "species_179838", "species_179856", "species_179856", "species_179838", "A0A6I8R443", "ENSXETG00000036250" ] }, "reaction_10324040": { "compartment": "compartment_172574", "id": "reaction_10324040", "reactome": "R-XTR-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10323998", "catalyst" ] ], "additional_components": [ "ENSXETT00000011460" ] }, "reaction_10324001": { "compartment": "compartment_172574", "id": "reaction_10324001", "reactome": "R-XTR-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_29372", "species_1806195" ], "modifiers": [ [ "species_10323998", "catalyst" ] ], "additional_components": [ "ENSXETT00000011460" ] }, "reaction_10335862": { "compartment": "compartment_70101", "id": "reaction_10335862", "reactome": "R-XTR-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_1602448" ], "products": [ "species_426755", "species_426658" ], "modifiers": [ [ "species_10335859", "catalyst" ] ], "additional_components": [ "ENSXETG00000020679" ] }, "reaction_10323390": { "compartment": "compartment_70101", "id": "reaction_10323390", "reactome": "R-XTR-1483096", "name": "PETA is dephosphorylated to ETA by PHOSPHO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428686" ], "products": [ "species_29372", "species_1498751" ], "modifiers": [ [ "species_10323387", "catalyst" ] ], "additional_components": [ "A0A6I8PRS6", "ENSXETG00000033588", "species_109496" ] }, "reaction_10323403": { "compartment": "compartment_70101", "id": "reaction_10323403", "reactome": "R-XTR-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10323371", "catalyst" ] ], "additional_components": [ "A0A6I8PNM3", "ENSXETG00000031132" ] }, "reaction_10323365": { "compartment": "compartment_12045", "id": "reaction_10323365", "reactome": "R-XTR-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_1500581", "species_109395" ], "modifiers": [ [ "species_10323362", "catalyst" ] ], "additional_components": [ "Q28H54", "ENSXETT00000009560", "species_109496", "CHEBI:29035", "A0A6I8QF66", "ENSXETG00000036824" ] }, "reaction_10323400": { "compartment": "compartment_12045", "id": "reaction_10323400", "reactome": "R-XTR-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_264618", "species_1500646" ], "modifiers": [ [ "species_10323397", "catalyst" ] ], "additional_components": [ "ENSXETG00000036605" ] }, "reaction_10323381": { "compartment": "compartment_12045", "id": "reaction_10323381", "reactome": "R-XTR-1483089", "name": "PE is converted to PS by PTDSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_1500581" ], "products": [ "species_1498751", "species_1500646" ], "modifiers": [ [ "species_10323378", "catalyst" ] ], "additional_components": [ "ENSXETG00000027078" ] }, "reaction_10323309": { "compartment": "compartment_70616", "id": "reaction_10323309", "reactome": "R-XTR-1482794", "name": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524072", "species_1524079" ], "products": [ "species_1524075", "species_1498773" ], "modifiers": [ [ "species_10323303", "catalyst" ] ], "additional_components": [ "ENSXETT00000007327" ] }, "reaction_10323341": { "compartment": "compartment_70616", "id": "reaction_10323341", "reactome": "R-XTR-1482894", "name": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524072", "species_1524089" ], "products": [ "species_1524083", "species_1498773" ], "modifiers": [ [ "species_10323303", "catalyst" ] ], "additional_components": [ "ENSXETT00000007327" ] }, "reaction_10323290": { "compartment": "compartment_70616", "id": "reaction_10323290", "reactome": "R-XTR-1482759", "name": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_113521" ], "products": [ "species_1498753", "species_1524085" ], "modifiers": [ [ "species_10323287", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323332": { "compartment": "compartment_12045", "id": "reaction_10323332", "reactome": "R-XTR-1482867", "name": "DLCL is acylated to MLCL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524080", "species_1500578" ], "products": [ "species_76194", "species_1524069" ], "modifiers": [ [ "species_10312131", "catalyst" ] ], "additional_components": [ "ENSXETT00000031524" ] }, "reaction_10323328": { "compartment": "compartment_12045", "id": "reaction_10323328", "reactome": "R-XTR-1482861", "name": "MLCL is acylated to CL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1524069" ], "products": [ "species_1524081", "species_76194" ], "modifiers": [ [ "species_10312131", "catalyst" ] ], "additional_components": [ "ENSXETT00000031524" ] }, "reaction_10331497": { "compartment": "compartment_12045", "id": "reaction_10331497", "reactome": "R-XTR-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10331494", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10323338": { "compartment": "compartment_12045", "id": "reaction_10323338", "reactome": "R-XTR-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10319042", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10334710": { "compartment": "compartment_12045", "id": "reaction_10334710", "reactome": "R-XTR-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10334707", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10323276": { "compartment": "compartment_12045", "id": "reaction_10323276", "reactome": "R-XTR-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498722" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323343": { "compartment": "compartment_12045", "id": "reaction_10323343", "reactome": "R-XTR-1482897", "name": "PS is hydrolyzed to 2-acyl LPS by PLA2[10]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500646" ], "products": [ "species_1498722", "species_1524021" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323299": { "compartment": "compartment_12045", "id": "reaction_10323299", "reactome": "R-XTR-1482771", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[9]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500646" ], "products": [ "species_1524021", "species_1498724" ], "modifiers": [ [ "species_10323296", "catalyst" ] ], "additional_components": [ "A0A6I8PMU8", "ENSXETG00000029956", "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323266": { "compartment": "compartment_12045", "id": "reaction_10323266", "reactome": "R-XTR-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498724" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323810": { "compartment": "compartment_984", "id": "reaction_10323810", "reactome": "R-XTR-1602374", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_33625" ], "products": [ "species_1602419", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10336015": { "compartment": "compartment_5460", "id": "reaction_10336015", "reactome": "R-XTR-8878654", "name": "ACP6 hydrolyses MYS-LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8878649", "species_113521" ], "products": [ "species_113548", "species_8934414" ], "modifiers": [ [ "species_10336012", "catalyst" ] ], "additional_components": [ "ENSXETT00000009623" ] }, "reaction_10312153": { "compartment": "compartment_70101", "id": "reaction_10312153", "reactome": "R-XTR-75889", "name": "DHAP is converted to G3P by GPD1/GPD1L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75970", "species_73473" ], "products": [ "species_76114", "species_29360" ], "modifiers": [ [ "species_10312150", "catalyst" ] ], "additional_components": [ "F6XXP1", "ENSXETT00000038446", "Q6P824", "ENSXETT00000032859" ] }, "reaction_10312136": { "compartment": "compartment_12045", "id": "reaction_10312136", "reactome": "R-XTR-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_426755", "species_76194" ], "modifiers": [ [ "species_10312133", "catalyst" ] ], "additional_components": [ "Q28C60", "ENSXETT00000037017", "F7A464", "ENSXETT00000031524" ] }, "reaction_10323256": { "compartment": "compartment_17906", "id": "reaction_10323256", "reactome": "R-XTR-1482604", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500590" ], "products": [ "species_1500580", "species_1524103" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10336024": { "compartment": "compartment_984", "id": "reaction_10336024", "reactome": "R-XTR-8878787", "name": "ALPI dimer hydrolyses phosphate monoesters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8878780" ], "products": [ "species_8878776", "species_109277" ], "modifiers": [ [ "species_10336021", "catalyst" ] ], "additional_components": [ "species_29426", "species_74112", "A0A6I8RU07", "ENSXETG00000032063" ] }, "reaction_10332427": { "compartment": "compartment_876", "id": "reaction_10332427", "reactome": "R-XTR-6792445", "name": "LIPH, I hydrolyse PA to 2-acyl LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602448" ], "products": [ "species_6792472", "species_1602366" ], "modifiers": [ [ "species_10332424", "catalyst" ] ], "additional_components": [ "Q5XGE9", "ENSXETG00000005849", "F6XB15", "ENSXETT00000048464", "L7N2H3", "ENSXETT00000002050" ] }, "reaction_10336954": { "compartment": "compartment_17906", "id": "reaction_10336954", "reactome": "R-XTR-8954398", "name": "PLD6 dimer hydrolyses cardiolipin to PA and PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189422", "species_8954419" ], "products": [ "species_8954401", "species_1500590" ], "modifiers": [ [ "species_10336945", "catalyst" ], [ "species_10336952", "catalyst" ] ], "additional_components": [ "Q28DT3", "ENSXETG00000005747", "A0A6I8QVP8", "ENSXETG00000018962" ] }, "reaction_10323818": { "compartment": "compartment_984", "id": "reaction_10323818", "reactome": "R-XTR-1602446", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602448" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10323270": { "compartment": "compartment_70101", "id": "reaction_10323270", "reactome": "R-XTR-1482656", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323283": { "compartment": "compartment_17906", "id": "reaction_10323283", "reactome": "R-XTR-1482695", "name": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_76194", "species_1500580" ], "modifiers": [ [ "species_10323280", "catalyst" ] ], "additional_components": [ "ENSXETG00000033567" ] }, "reaction_10332322": { "compartment": "compartment_70101", "id": "reaction_10332322", "reactome": "R-XTR-6786650", "name": "DDHD1,2 hydrolyse PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1602448" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10332319", "catalyst" ] ], "additional_components": [ "A0A6I8SK52", "ENSXETG00000015184", "A0A6I8QC54", "ENSXETG00000038294" ] }, "reaction_10323321": { "compartment": "compartment_12045", "id": "reaction_10323321", "reactome": "R-XTR-1482828", "name": "PE is hydrolyzed to 2-acyl LPE by PLA2[4]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498729", "species_1524021" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323336": { "compartment": "compartment_12045", "id": "reaction_10323336", "reactome": "R-XTR-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10323313", "catalyst" ] ], "additional_components": [ "ENSXETG00000015758" ] }, "reaction_10323272": { "compartment": "compartment_12045", "id": "reaction_10323272", "reactome": "R-XTR-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498738" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10335402": { "compartment": "compartment_70101", "id": "reaction_10335402", "reactome": "R-XTR-8858298", "name": "HRASLS transfer acyl group from PC to PE to form NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_1500581" ], "products": [ "species_5694568", "species_6814253" ], "modifiers": [ [ "species_10335399", "catalyst" ] ], "additional_components": [ "A0A6I8PMU8", "ENSXETG00000029956", "A0A6I8SG35", "ENSXETG00000035934", "A0A6I8RYC6", "ENSXETG00000038318", "A0A6I8Q9S3", "ENSXETG00000035934" ] }, "reaction_10323268": { "compartment": "compartment_12045", "id": "reaction_10323268", "reactome": "R-XTR-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323334": { "compartment": "compartment_12045", "id": "reaction_10323334", "reactome": "R-XTR-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10323296", "catalyst" ] ], "additional_components": [ "A0A6I8PMU8", "ENSXETG00000029956", "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323814": { "compartment": "compartment_984", "id": "reaction_10323814", "reactome": "R-XTR-1602398", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602375", "species_109276" ], "products": [ "species_1602372", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10323262": { "compartment": "compartment_12045", "id": "reaction_10323262", "reactome": "R-XTR-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10323248", "catalyst" ] ], "additional_components": [ "ENSXETG00000036938" ] }, "reaction_10323812": { "compartment": "compartment_984", "id": "reaction_10323812", "reactome": "R-XTR-1602377", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_426658" ], "products": [ "species_1602420", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10323318": { "compartment": "compartment_12045", "id": "reaction_10323318", "reactome": "R-XTR-1482825", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[11]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426639" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10323296", "catalyst" ] ], "additional_components": [ "A0A6I8PMU8", "ENSXETG00000029956", "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323251": { "compartment": "compartment_12045", "id": "reaction_10323251", "reactome": "R-XTR-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10323248", "catalyst" ] ], "additional_components": [ "ENSXETG00000036938" ] }, "reaction_10323259": { "compartment": "compartment_12045", "id": "reaction_10323259", "reactome": "R-XTR-1482612", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_975614" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323274": { "compartment": "compartment_12045", "id": "reaction_10323274", "reactome": "R-XTR-1482685", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1524028" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323374": { "compartment": "compartment_70101", "id": "reaction_10323374", "reactome": "R-XTR-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_113592" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10323371", "catalyst" ] ], "additional_components": [ "A0A6I8PNM3", "ENSXETG00000031132" ] }, "reaction_10318360": { "compartment": "compartment_984", "id": "reaction_10318360", "reactome": "R-XTR-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10318357", "catalyst" ] ], "additional_components": [ "ENSXETG00000002987" ] }, "reaction_10323354": { "compartment": "compartment_12045", "id": "reaction_10323354", "reactome": "R-XTR-1482961", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524060", "species_1500596" ], "products": [ "species_426925", "species_109395" ], "modifiers": [ [ "species_10323351", "catalyst" ] ], "additional_components": [ "Q28H54", "ENSXETT00000009560", "species_109496", "CHEBI:29035" ] }, "reaction_10323393": { "compartment": "compartment_70101", "id": "reaction_10323393", "reactome": "R-XTR-1483159", "name": "PCho is dephosphorylated to Cho by PHOSPHO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1524071" ], "products": [ "species_264618", "species_29372" ], "modifiers": [ [ "species_10323387", "catalyst" ] ], "additional_components": [ "A0A6I8PRS6", "ENSXETG00000033588", "species_109496" ] }, "reaction_10335730": { "compartment": "compartment_984", "id": "reaction_10335730", "reactome": "R-XTR-8865637", "name": "MFSD2A transports LPC from extracellular region to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8865642", "species_74113" ], "products": [ "species_8865629", "species_83910" ], "modifiers": [ [ "species_10335727", "catalyst" ] ], "additional_components": [ "ENSXETT00000002564" ] }, "reaction_10323325": { "compartment": "compartment_12045", "id": "reaction_10323325", "reactome": "R-XTR-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10323296", "catalyst" ] ], "additional_components": [ "A0A6I8PMU8", "ENSXETG00000029956", "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323244": { "compartment": "compartment_12045", "id": "reaction_10323244", "reactome": "R-XTR-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323816": { "compartment": "compartment_984", "id": "reaction_10323816", "reactome": "R-XTR-1602417", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_429802" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10323316": { "compartment": "compartment_12045", "id": "reaction_10323316", "reactome": "R-XTR-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10323313", "catalyst" ] ], "additional_components": [ "ENSXETG00000015758" ] }, "reaction_10323239": { "compartment": "compartment_12045", "id": "reaction_10323239", "reactome": "R-XTR-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_975614" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323330": { "compartment": "compartment_12045", "id": "reaction_10323330", "reactome": "R-XTR-1482862", "name": "PC is hydrolysed to 2-acyl LPC by PLA2[7]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524021", "species_975614" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323242": { "compartment": "compartment_12045", "id": "reaction_10323242", "reactome": "R-XTR-1482539", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498740" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323345": { "compartment": "compartment_12045", "id": "reaction_10323345", "reactome": "R-XTR-1482900", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1524021", "species_1498740" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323264": { "compartment": "compartment_12045", "id": "reaction_10323264", "reactome": "R-XTR-1482635", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498730", "species_1500578" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323808": { "compartment": "compartment_984", "id": "reaction_10323808", "reactome": "R-XTR-1602368", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602402" ], "products": [ "species_1602415", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10311977": { "compartment": "compartment_5460", "id": "reaction_10311977", "reactome": "R-XTR-74181", "name": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_73871" ], "products": [ "species_113559" ], "modifiers": [ [ "species_10311582", "catalyst" ] ], "additional_components": [ "Q5BKN8", "ENSXETT00000031684" ] }, "reaction_10311959": { "compartment": "compartment_5460", "id": "reaction_10311959", "reactome": "R-XTR-73920", "name": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_73911" ], "products": [ "species_113529", "species_73909", "species_29362" ], "modifiers": [ [ "species_10311952", "catalyst" ] ], "additional_components": [ "F6RPR3", "ENSXETT00000007485" ] }, "reaction_10331407": { "compartment": "compartment_70101", "id": "reaction_10331407", "reactome": "R-XTR-5694494", "name": "AACS ligates CoA-SH to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_29666" ], "products": [ "species_111294", "species_191293", "species_76577" ], "modifiers": [ [ "species_10331404", "catalyst" ] ], "additional_components": [ "ENSXETG00000001210" ] }, "reaction_10335941": { "compartment": "compartment_5460", "id": "reaction_10335941", "reactome": "R-XTR-8875071", "name": "ACSS3 ligates CoA to CH3COO-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_113539" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10335938", "catalyst" ] ], "additional_components": [ "ENSXETG00000014528" ] }, "reaction_10332359": { "compartment": "compartment_70101", "id": "reaction_10332359", "reactome": "R-XTR-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_76183", "species_29666" ], "modifiers": [ [ "species_10332356", "catalyst" ] ], "additional_components": [ "species_109496", "A0A6I8PVX1", "ENSXETG00000007070" ] }, "reaction_10311955": { "compartment": "compartment_5460", "id": "reaction_10311955", "reactome": "R-XTR-73912", "name": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_73909", "species_29362" ], "products": [ "species_113526", "species_73911" ], "modifiers": [ [ "species_10311952", "catalyst" ] ], "additional_components": [ "F6RPR3", "ENSXETT00000007485" ] }, "reaction_10331506": { "compartment": "compartment_70101", "id": "reaction_10331506", "reactome": "R-XTR-5696457", "name": "BDH2 dehydrogenates 3HBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696461", "species_29360" ], "products": [ "species_70106", "species_29666", "species_73473" ], "modifiers": [ [ "species_10331503", "catalyst" ] ], "additional_components": [ "A0A6I8RES0", "ENSXETG00000021320" ] }, "reaction_10337487": { "compartment": "compartment_70101", "id": "reaction_10337487", "reactome": "R-XTR-9020255", "name": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024765" ], "products": [ "species_9024768", "species_29364" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337499": { "compartment": "compartment_70101", "id": "reaction_10337499", "reactome": "R-XTR-9020282", "name": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024765" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337493": { "compartment": "compartment_70101", "id": "reaction_10337493", "reactome": "R-XTR-9020264", "name": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024797" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337495": { "compartment": "compartment_70101", "id": "reaction_10337495", "reactome": "R-XTR-9020277", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024797" ], "products": [ "species_29364", "species_9024781" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337485": { "compartment": "compartment_70101", "id": "reaction_10337485", "reactome": "R-XTR-9020251", "name": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024463" ], "products": [ "species_9024479" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337497": { "compartment": "compartment_70101", "id": "reaction_10337497", "reactome": "R-XTR-9020278", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024576", "species_29366" ], "products": [ "species_9024577", "species_29364" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337489": { "compartment": "compartment_70101", "id": "reaction_10337489", "reactome": "R-XTR-9020256", "name": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024479" ], "products": [ "species_29364", "species_9024602" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337491": { "compartment": "compartment_70101", "id": "reaction_10337491", "reactome": "R-XTR-9020259", "name": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024463" ], "products": [ "species_9024576" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337534": { "compartment": "compartment_70101", "id": "reaction_10337534", "reactome": "R-XTR-9024997", "name": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025012", "species_29368" ], "products": [ "species_9024989" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337565": { "compartment": "compartment_70101", "id": "reaction_10337565", "reactome": "R-XTR-9027321", "name": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9027049" ], "products": [ "species_29356", "species_29366", "species_9027324" ], "modifiers": [ [ "species_10312165", "catalyst" ] ], "additional_components": [ "CHEBI:137368", "CHEBI:137361", "ENSXETG00000033706" ] }, "reaction_10337560": { "compartment": "compartment_70101", "id": "reaction_10337560", "reactome": "R-XTR-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9024011" ], "products": [ "species_29356", "species_29366", "species_9027049" ], "modifiers": [ [ "species_10337557", "catalyst" ] ], "additional_components": [ "A4IGV4", "ENSXETT00000061279", "A0A6I8PUP3", "ENSXETG00000033706", "F7B981", "ENSXETT00000026362", "A0A6I8Q6H5", "ENSXETT00000026362" ] }, "reaction_10337563": { "compartment": "compartment_70101", "id": "reaction_10337563", "reactome": "R-XTR-9027302", "name": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9027029", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_9027326", "species_29366" ], "modifiers": [ [ "species_10312165", "catalyst" ] ], "additional_components": [ "CHEBI:137360", "CHEBI:137354", "ENSXETG00000033706" ] }, "reaction_10337696": { "compartment": "compartment_12045", "id": "reaction_10337696", "reactome": "R-XTR-9037761", "name": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024886", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_9037755" ], "modifiers": [ [ "species_10312224", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10337555": { "compartment": "compartment_70101", "id": "reaction_10337555", "reactome": "R-XTR-9026911", "name": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024768" ], "products": [ "species_9026915" ], "modifiers": [ [ "species_10337550", "catalyst" ] ], "additional_components": [ "A0A6I8QSM3", "ENSXETG00000036146" ] }, "reaction_10337553": { "compartment": "compartment_70101", "id": "reaction_10337553", "reactome": "R-XTR-9026780", "name": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9025001" ], "products": [ "species_9026761" ], "modifiers": [ [ "species_10337550", "catalyst" ] ], "additional_components": [ "A0A6I8QSM3", "ENSXETG00000036146" ] }, "reaction_10337567": { "compartment": "compartment_70101", "id": "reaction_10337567", "reactome": "R-XTR-9027624", "name": "ALOX5 oxidises DHA to 7-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024011" ], "products": [ "species_9028274" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337569": { "compartment": "compartment_70101", "id": "reaction_10337569", "reactome": "R-XTR-9027628", "name": "ALOX5 oxidises EPA to 5-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2026977", "species_29368" ], "products": [ "species_9028283" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337571": { "compartment": "compartment_70101", "id": "reaction_10337571", "reactome": "R-XTR-9027633", "name": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9608444", "species_29368" ], "products": [ "species_9028240" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337542": { "compartment": "compartment_70101", "id": "reaction_10337542", "reactome": "R-XTR-9026005", "name": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026293", "species_29368" ], "products": [ "species_9026311" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337544": { "compartment": "compartment_70101", "id": "reaction_10337544", "reactome": "R-XTR-9026405", "name": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026400", "species_29368" ], "products": [ "species_9026394" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "CHEBI:137020", "CHEBI:137011", "CHEBI:137018", "CHEBI:137019", "ENSXETG00000007490" ] }, "reaction_10337540": { "compartment": "compartment_70101", "id": "reaction_10337540", "reactome": "R-XTR-9025999", "name": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9026047" ], "products": [ "species_9026046", "species_29364" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337536": { "compartment": "compartment_70101", "id": "reaction_10337536", "reactome": "R-XTR-9025995", "name": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026034", "species_29366" ], "products": [ "species_9026050", "species_29364" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337538": { "compartment": "compartment_70101", "id": "reaction_10337538", "reactome": "R-XTR-9025996", "name": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9026047" ], "products": [ "species_9026034" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337481": { "compartment": "compartment_70101", "id": "reaction_10337481", "reactome": "R-XTR-9018863", "name": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023651", "species_29368" ], "products": [ "species_9023702" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337483": { "compartment": "compartment_70101", "id": "reaction_10337483", "reactome": "R-XTR-9018894", "name": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023702", "species_29368" ], "products": [ "species_9023708" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337477": { "compartment": "compartment_70101", "id": "reaction_10337477", "reactome": "R-XTR-9018858", "name": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9020474" ], "products": [ "species_9020602" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337479": { "compartment": "compartment_70101", "id": "reaction_10337479", "reactome": "R-XTR-9018859", "name": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9020602" ], "products": [ "species_9022655" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10312123": { "compartment": "compartment_70101", "id": "reaction_10312123", "reactome": "R-XTR-75883", "name": "DHRS7B reduces GO3P to HXDG3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75973", "species_29364" ], "products": [ "species_29366", "species_390422" ], "modifiers": [ [ "species_10312120", "catalyst" ] ], "additional_components": [ "ENSXETT00000013330" ] }, "reaction_10334716": { "compartment": "compartment_12045", "id": "reaction_10334716", "reactome": "R-XTR-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200993", "species_30209" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10331494", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10334713": { "compartment": "compartment_12045", "id": "reaction_10334713", "reactome": "R-XTR-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_8848499", "species_76194" ], "modifiers": [ [ "species_10331494", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10326149": { "compartment": "compartment_70101", "id": "reaction_10326149", "reactome": "R-XTR-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_2162081", "species_73473" ], "modifiers": [ [ "species_10311790", "catalyst" ] ], "additional_components": [ "A0A6I8RYK1", "ENSXETG00000032351", "species_29426" ] }, "reaction_10326146": { "compartment": "compartment_70101", "id": "reaction_10326146", "reactome": "R-XTR-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10312008", "catalyst" ] ], "additional_components": [ "species_109496", "Q5EBF1", "ENSXETG00000009475" ] }, "reaction_10324293": { "compartment": "compartment_876", "id": "reaction_10324293", "reactome": "R-XTR-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10324290", "catalyst" ] ], "additional_components": [ "species_74112", "A0A6I8QLK5", "ENSXETG00000030514", "A0A6I8SLR0", "ENSXETG00000003578", "A0A6I8QCS0", "ENSXETG00000007772" ] }, "reaction_10324274": { "compartment": "compartment_70101", "id": "reaction_10324274", "reactome": "R-XTR-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10324015", "catalyst" ] ], "additional_components": [ "ENSXETG00000009899" ] }, "reaction_10324265": { "compartment": "compartment_70101", "id": "reaction_10324265", "reactome": "R-XTR-1855202", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629746" ], "products": [ "species_29372", "species_1629731" ], "modifiers": [ [ "species_10324057", "catalyst" ] ], "additional_components": [ "ENSXETG00000019407" ] }, "reaction_10324246": { "compartment": "compartment_70101", "id": "reaction_10324246", "reactome": "R-XTR-1855180", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994123" ], "products": [ "species_29372", "species_1629769" ], "modifiers": [ [ "species_10324057", "catalyst" ] ], "additional_components": [ "ENSXETG00000019407" ] }, "reaction_10324243": { "compartment": "compartment_70101", "id": "reaction_10324243", "reactome": "R-XTR-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10324015", "catalyst" ] ], "additional_components": [ "ENSXETG00000009899" ] }, "reaction_10324268": { "compartment": "compartment_7660", "id": "reaction_10324268", "reactome": "R-XTR-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10324230", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324249": { "compartment": "compartment_7660", "id": "reaction_10324249", "reactome": "R-XTR-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10324230", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324233": { "compartment": "compartment_7660", "id": "reaction_10324233", "reactome": "R-XTR-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10324230", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324299": { "compartment": "compartment_7660", "id": "reaction_10324299", "reactome": "R-XTR-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023940" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10324230", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324305": { "compartment": "compartment_7660", "id": "reaction_10324305", "reactome": "R-XTR-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023922" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10324230", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10323209": { "compartment": "compartment_876", "id": "reaction_10323209", "reactome": "R-XTR-1475017", "name": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10322211", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8QID1", "ENSXETG00000034545" ] }, "reaction_10323220": { "compartment": "compartment_876", "id": "reaction_10323220", "reactome": "R-XTR-1475025", "name": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10322211", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8QID1", "ENSXETG00000034545" ] }, "reaction_10323222": { "compartment": "compartment_70101", "id": "reaction_10323222", "reactome": "R-XTR-1475026", "name": "Carbonic anhydrase hydrates carbon dioxide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113528" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10323215", "catalyst" ] ], "additional_components": [ "Q28CD7", "ENSXETT00000069496", "species_29426" ] }, "reaction_10323218": { "compartment": "compartment_70101", "id": "reaction_10323218", "reactome": "R-XTR-1475022", "name": "Carbonic anhydrase dehydrates bicarbonate (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_29356", "species_113528" ], "modifiers": [ [ "species_10323215", "catalyst" ] ], "additional_components": [ "Q28CD7", "ENSXETT00000069496", "species_29426" ] }, "reaction_10331322": { "compartment": "compartment_17963", "id": "reaction_10331322", "reactome": "R-XTR-5693925", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693930", "species_205683" ], "products": [ "species_5693933", "species_205689" ], "modifiers": [ [ "species_10331319", "catalyst" ] ], "additional_components": [ "ENSXETG00000032714" ] }, "reaction_10321826": { "compartment": "compartment_20699", "id": "reaction_10321826", "reactome": "R-XTR-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10321823", "catalyst" ] ], "additional_components": [ "ENSXETT00000016641" ] }, "reaction_10318217": { "compartment": "compartment_1462052", "id": "reaction_10318217", "reactome": "R-XTR-437085", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10318214", "catalyst" ] ], "additional_components": [ "ENSXETG00000000472" ] }, "reaction_10318231": { "compartment": "compartment_20699", "id": "reaction_10318231", "reactome": "R-XTR-437139", "name": "ZnT6 transports zinc into the golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216667" ], "modifiers": [ [ "species_10318228", "catalyst" ] ], "additional_components": [ "ENSXETT00000054089" ] }, "reaction_10318224": { "compartment": "compartment_20699", "id": "reaction_10318224", "reactome": "R-XTR-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10318221", "catalyst" ] ], "additional_components": [ "ENSXETG00000027945" ] }, "reaction_10318210": { "compartment": "compartment_876", "id": "reaction_10318210", "reactome": "R-XTR-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10318207", "catalyst" ] ], "additional_components": [ "ENSXETG00000034450" ] }, "reaction_10336888": { "compartment": "compartment_70101", "id": "reaction_10336888", "reactome": "R-XTR-8952716", "name": "SLC38A9 binds Ragulator:Rag dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330239", "species_10330253" ], "products": [ "species_10330255" ], "modifiers": [], "additional_components": [ "ENSXETG00000028090", "F6W400", "ENSXETT00000041436", "species_29438", "B4F6Y3", "ENSXETG00000026765", "Q6DF40", "ENSXETG00000020403", "A9UL91", "ENSXETT00000103950", "Q6P2W7", "ENSXETG00000024963", "F6W400", "ENSXETT00000041436", "species_29438", "B4F6Y3", "ENSXETG00000026765", "Q6DF40", "ENSXETG00000020403", "A9UL91", "ENSXETT00000103950", "Q6P2W7", "ENSXETG00000024963", "A0A6I8RIW4", "ENSXETG00000028090" ] }, "reaction_10336891": { "compartment": "compartment_70101", "id": "reaction_10336891", "reactome": "R-XTR-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10330255", "catalyst" ] ], "additional_components": [ "F6W400", "ENSXETT00000041436", "species_29438", "B4F6Y3", "ENSXETG00000026765", "Q6DF40", "ENSXETG00000020403", "A9UL91", "ENSXETT00000103950", "Q6P2W7", "ENSXETG00000024963", "A0A6I8RIW4", "ENSXETG00000028090" ] }, "reaction_10338102": { "compartment": "compartment_70101", "id": "reaction_10338102", "reactome": "R-XTR-9679044", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338098", "species_9678687" ], "products": [ "species_10338100" ], "modifiers": [], "additional_components": [ "ENSXETT00000003463", "F7BKJ1", "ENSXETT00000003463" ] }, "reaction_10338253": { "compartment": "compartment_984", "id": "reaction_10338253", "reactome": "R-XTR-9707586", "name": "FeHM oxidises LDL,HDL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338243", "species_917955" ], "products": [ "species_917877", "species_10338251" ], "modifiers": [], "additional_components": [ "species_171126", "A0A6I8RKY6", "ENSXETG00000026768", "species_163579", "species_171142", "species_216762", "species_171126", "A0A6I8RKY6", "ENSXETG00000026768", "species_163579", "species_2186967", "species_171142", "species_216762" ] }, "reaction_10338255": { "compartment": "compartment_7660", "id": "reaction_10338255", "reactome": "R-XTR-9707690", "name": "BACH1 binds MAFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321780", "species_10338235" ], "products": [ "species_10338237" ], "modifiers": [], "additional_components": [ "ENSXETT00000041786", "ENSXETT00000017505", "F6Y302", "ENSXETT00000017505", "F7A9R6", "ENSXETT00000041786" ] }, "reaction_10338231": { "compartment": "compartment_984", "id": "reaction_10338231", "reactome": "R-XTR-9707516", "name": "FeHM dissociates from MetHb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326232" ], "products": [ "species_917955", "species_10338229" ], "modifiers": [], "additional_components": [ "P07428", "ENSXETT00000002494", "species_917955", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "P07428", "ENSXETT00000002494", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627" ] }, "reaction_10338241": { "compartment": "compartment_7660", "id": "reaction_10338241", "reactome": "R-XTR-9707523", "name": "Hemes bind to BACH1:MAFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707575", "species_10338237" ], "products": [ "species_10321780", "species_10338239" ], "modifiers": [], "additional_components": [ "F6Y302", "ENSXETT00000017505", "F7A9R6", "ENSXETT00000041786", "ENSXETT00000041786", "F6Y302", "ENSXETT00000017505" ] }, "reaction_10338226": { "compartment": "compartment_984", "id": "reaction_10338226", "reactome": "R-XTR-9707504", "name": "H2O2 oxidises ferrohemoglobin to MetHb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_10338222" ], "products": [ "species_9707624", "species_9707647", "species_10326232" ], "modifiers": [ [ "species_10338224", "inhibitor" ] ], "additional_components": [ "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494", "P07428", "ENSXETT00000002494", "species_917955", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_9709335", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494" ] }, "reaction_10327581": { "compartment": "compartment_70101", "id": "reaction_10327581", "reactome": "R-XTR-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29368", "species_29408" ], "modifiers": [ [ "species_10327578", "catalyst" ] ], "additional_components": [ "species_29426", "species_209799", "Q0IIW3", "ENSXETT00000015994" ] }, "reaction_10331455": { "compartment": "compartment_5460", "id": "reaction_10331455", "reactome": "R-XTR-5696197", "name": "NUDT2 hydrolyses GP4G to GTP, GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696199", "species_113521" ], "products": [ "species_5696194", "species_113573" ], "modifiers": [ [ "species_10331452", "catalyst" ] ], "additional_components": [ "ENSXETT00000004614" ] }, "reaction_10327705": { "compartment": "compartment_70616", "id": "reaction_10327705", "reactome": "R-XTR-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_10313148" ], "products": [ "species_189461", "species_10313146" ], "modifiers": [], "additional_components": [ "Q640U4", "ENSXETT00000018532", "Q6PBF4", "ENSXETT00000049267", "CHEBI:38574", "Q640U4", "ENSXETT00000018532", "Q6PBF4", "ENSXETT00000049267", "CHEBI:38573" ] }, "reaction_10328075": { "compartment": "compartment_5460", "id": "reaction_10328075", "reactome": "R-XTR-3697894", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327691", "species_3697881" ], "products": [ "species_3697842", "species_10327694", "species_113521" ], "modifiers": [ [ "species_10327698", "catalyst" ] ], "additional_components": [ "ENSXETT00000089705", "ENSXETT00000089705", "ENSXETT00000013225" ] }, "reaction_10328149": { "compartment": "compartment_17927", "id": "reaction_10328149", "reactome": "R-XTR-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10328146", "catalyst" ] ], "additional_components": [ "species_209799", "Q0IIW3", "ENSXETT00000015994", "species_29426" ] }, "reaction_10327701": { "compartment": "compartment_5460", "id": "reaction_10327701", "reactome": "R-XTR-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327691", "species_1614617" ], "products": [ "species_10327694", "species_113521" ], "modifiers": [ [ "species_10327698", "catalyst" ] ], "additional_components": [ "ENSXETT00000089705", "ENSXETT00000089705", "ENSXETT00000013225" ] }, "reaction_10327715": { "compartment": "compartment_984", "id": "reaction_10327715", "reactome": "R-XTR-3341397", "name": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_1247892" ], "products": [ "species_109276", "species_3341331" ], "modifiers": [ [ "species_10327712", "catalyst" ] ], "additional_components": [ "Q6P8G5", "ENSXETT00000098364" ] }, "reaction_10333618": { "compartment": "compartment_984", "id": "reaction_10333618", "reactome": "R-XTR-6799695", "name": "GPX5,6 reduce H2O2 to H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_1247892" ], "products": [ "species_109276", "species_3341331" ], "modifiers": [ [ "species_10333613", "catalyst" ] ], "additional_components": [ "ENSXETT00000098364" ] }, "reaction_10338265": { "compartment": "compartment_984", "id": "reaction_10338265", "reactome": "R-XTR-9709317", "name": "CO binds to free ferrohemoglobin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338222", "species_9709335" ], "products": [ "species_10338224" ], "modifiers": [], "additional_components": [ "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494", "species_9709335", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494" ] }, "reaction_10338267": { "compartment": "compartment_984", "id": "reaction_10338267", "reactome": "R-XTR-9709360", "name": "H2O2 reduces MetHb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_10326232" ], "products": [ "species_109276", "species_10338222", "species_352327" ], "modifiers": [], "additional_components": [ "P07428", "ENSXETT00000002494", "species_917955", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494" ] }, "reaction_10338261": { "compartment": "compartment_70101", "id": "reaction_10338261", "reactome": "R-XTR-9708466", "name": "BACH1 translocates from the nucleoplasm to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338235" ], "products": [ "species_10338259" ], "modifiers": [ [ "species_3785707", "catalyst" ] ], "additional_components": [ "ENSXETT00000017505", "ENSXETT00000017505" ] }, "reaction_10321885": { "compartment": "compartment_70101", "id": "reaction_10321885", "reactome": "R-XTR-1234161", "name": "HIF-alpha translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321881" ], "products": [ "species_10321883" ], "modifiers": [], "additional_components": [ "ENSXETG00000026167", "ENSXETG00000026167" ] }, "reaction_10328289": { "compartment": "compartment_7660", "id": "reaction_10328289", "reactome": "R-XTR-3857336", "name": "CEBPB homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328281" ], "products": [ "species_10328283" ], "modifiers": [], "additional_components": [ "ENSXETT00000085676", "Q3SYP1", "ENSXETT00000085676" ] }, "reaction_10327348": { "compartment": "compartment_7660", "id": "reaction_10327348", "reactome": "R-XTR-3240295", "name": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10327345" ], "products": [ "species_77502", "species_10327343" ], "modifiers": [ [ "species_10316473", "catalyst" ] ], "additional_components": [ "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146" ] }, "reaction_10327310": { "compartment": "compartment_7660", "id": "reaction_10327310", "reactome": "R-XTR-3209159", "name": "Phosphorylated ERF translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327306" ], "products": [ "species_10327308" ], "modifiers": [], "additional_components": [ "ENSXETG00000012067", "ENSXETG00000012067" ] }, "reaction_10312580": { "compartment": "compartment_876", "id": "reaction_10312580", "reactome": "R-XTR-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10312577", "catalyst" ] ], "additional_components": [ "L7N333", "ENSXETT00000019255", "F6WUY6", "ENSXETT00000027105", "species_109496" ] }, "reaction_10312589": { "compartment": "compartment_70101", "id": "reaction_10312589", "reactome": "R-XTR-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10312586", "catalyst" ] ], "additional_components": [ "F6YP15", "ENSXETT00000040456" ] }, "reaction_10312591": { "compartment": "compartment_70101", "id": "reaction_10312591", "reactome": "R-XTR-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312586" ], "products": [ "species_10312586" ], "modifiers": [], "additional_components": [ "F6YP15", "ENSXETT00000040456", "F6YP15", "ENSXETT00000040456" ] }, "reaction_10335005": { "compartment": "compartment_17963", "id": "reaction_10335005", "reactome": "R-XTR-8851619", "name": "GALNT3 transfers GalNAc to FGF23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10335000" ], "products": [ "species_10335002", "species_205687" ], "modifiers": [ [ "species_10320310", "catalyst" ] ], "additional_components": [ "ENSXETG00000026353", "ENSXETG00000026353", "ENSXETT00000045011" ] }, "reaction_10335007": { "compartment": "compartment_17963", "id": "reaction_10335007", "reactome": "R-XTR-8851632", "name": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335002" ], "products": [ "species_10314114" ], "modifiers": [], "additional_components": [ "ENSXETG00000026353", "ENSXETG00000026353" ] }, "reaction_10320127": { "compartment": "compartment_876", "id": "reaction_10320127", "reactome": "R-XTR-877187", "name": "P2X7 mediates loss of intracellular K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10320124", "catalyst" ] ], "additional_components": [ "A0A6I8S619", "ENSXETG00000041261", "species_113593" ] }, "reaction_10320159": { "compartment": "compartment_70101", "id": "reaction_10320159", "reactome": "R-XTR-879221", "name": "PSTPIP1 binds Pyrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320155", "species_10320139" ], "products": [ "species_10320157" ], "modifiers": [], "additional_components": [ "A0A6I8QK31", "ENSXETG00000033202", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8QK31", "ENSXETG00000033202", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292" ] }, "reaction_10320120": { "compartment": "compartment_70101", "id": "reaction_10320120", "reactome": "R-XTR-844447", "name": "NLRP1 senses MDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_708341", "species_10320110" ], "products": [ "species_10320112" ], "modifiers": [], "additional_components": [ "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "species_708341" ] }, "reaction_10320149": { "compartment": "compartment_70101", "id": "reaction_10320149", "reactome": "R-XTR-879201", "name": "Bcl-2 and Bcl-XL bind NLRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320145", "species_10320110" ], "products": [ "species_10320147" ], "modifiers": [], "additional_components": [ "A0A6I8QYM7", "ENSXETG00000035771", "F6XC18", "ENSXETT00000050759", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "A0A6I8QYM7", "ENSXETG00000035771", "F6XC18", "ENSXETT00000050759" ] }, "reaction_10320118": { "compartment": "compartment_70101", "id": "reaction_10320118", "reactome": "R-XTR-844438", "name": "NLRP1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320114" ], "products": [ "species_10320116" ], "modifiers": [], "additional_components": [ "species_113593", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "species_708341", "species_113593", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "species_708341" ] }, "reaction_10320161": { "compartment": "compartment_70101", "id": "reaction_10320161", "reactome": "R-XTR-879222", "name": "MDP:NLRP1 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320112", "species_113592" ], "products": [ "species_10320114" ], "modifiers": [], "additional_components": [ "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "species_708341", "species_113593", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "species_708341" ] }, "reaction_10320168": { "compartment": "compartment_876", "id": "reaction_10320168", "reactome": "R-XTR-879585", "name": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879559" ], "products": [ "species_879544" ], "modifiers": [ [ "species_10320165", "catalyst" ] ], "additional_components": [ "CHEBI:16196", "CHEBI:16196", "ENSXETG00000037018" ] }, "reaction_10322403": { "compartment": "compartment_876", "id": "reaction_10322403", "reactome": "R-XTR-1299304", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10322400", "catalyst" ] ], "additional_components": [ "F7AEN8", "ENSXETT00000009094" ] }, "reaction_10322456": { "compartment": "compartment_984", "id": "reaction_10322456", "reactome": "R-XTR-1362465", "name": "GHBP binds GHR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320900", "species_10320910" ], "products": [ "species_10320912" ], "modifiers": [], "additional_components": [ "ENSXETG00000037965", "ENSXETG00000037965", "A0A6I8PXI3", "ENSXETG00000037965" ] }, "reaction_10320917": { "compartment": "compartment_70101", "id": "reaction_10320917", "reactome": "R-XTR-982792", "name": "Growth hormone receptor binds JAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320900", "species_10320904" ], "products": [ "species_10320906" ], "modifiers": [], "additional_components": [ "ENSXETG00000037965", "ENSXETG00000000586", "A0A6I8QZL9", "ENSXETG00000000586", "A0A6I8PXI3", "ENSXETG00000037965" ] }, "reaction_10320914": { "compartment": "compartment_876", "id": "reaction_10320914", "reactome": "R-XTR-982775", "name": "Growth hormone receptor dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320906" ], "products": [ "species_10320908" ], "modifiers": [ [ "species_10320912", "inhibitor" ] ], "additional_components": [ "A0A6I8QZL9", "ENSXETG00000000586", "A0A6I8PXI3", "ENSXETG00000037965", "A0A6I8QZL9", "ENSXETG00000000586", "A0A6I8PXI3", "ENSXETG00000037965", "A0A6I8PXI3", "ENSXETG00000037965" ] }, "reaction_10330559": { "compartment": "compartment_876", "id": "reaction_10330559", "reactome": "R-XTR-5676592", "name": "2xRANK binds RANKL,sRANKL trimer:RANK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330551", "species_10330553" ], "products": [ "species_10330557" ], "modifiers": [], "additional_components": [ "ENSXETT00000001109", "F7DPT4", "ENSXETT00000001109", "F6WJ69", "ENSXETT00000005335", "A0A6I8PXA6", "ENSXETG00000030595", "F7DPT4", "ENSXETT00000001109", "F6WJ69", "ENSXETT00000005335", "A0A6I8PXA6", "ENSXETG00000030595" ] }, "reaction_10330555": { "compartment": "compartment_876", "id": "reaction_10330555", "reactome": "R-XTR-5676589", "name": "RANKL,sRANKL trimer binds RANK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330455", "species_10330551" ], "products": [ "species_10330553" ], "modifiers": [], "additional_components": [ "F6WJ69", "ENSXETT00000005335", "A0A6I8PXA6", "ENSXETG00000030595", "ENSXETT00000001109", "F7DPT4", "ENSXETT00000001109", "F6WJ69", "ENSXETT00000005335", "A0A6I8PXA6", "ENSXETG00000030595" ] }, "reaction_10330429": { "compartment": "compartment_876", "id": "reaction_10330429", "reactome": "R-XTR-5669012", "name": "EDA binds EDAR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330421", "species_10330425" ], "products": [ "species_10330427" ], "modifiers": [], "additional_components": [ "ENSXETG00000039649", "ENSXETT00000004819", "Q6DF68", "ENSXETT00000004819", "A0A6I8RPF6", "ENSXETG00000039649" ] }, "reaction_10330437": { "compartment": "compartment_876", "id": "reaction_10330437", "reactome": "R-XTR-5669013", "name": "EDA-3 binds EDA2R", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330433", "species_10330421" ], "products": [ "species_10330435" ], "modifiers": [], "additional_components": [ "ENSXETT00000025196", "ENSXETG00000039649", "A0A6I8RPF6", "ENSXETG00000039649", "F7D7R4", "ENSXETT00000025196" ] }, "reaction_10330465": { "compartment": "compartment_876", "id": "reaction_10330465", "reactome": "R-XTR-5669097", "name": "LTA trimer binds TNFRSF1A,1B,14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330459", "species_10330461" ], "products": [ "species_10330463" ], "modifiers": [], "additional_components": [ "A0A6I8PXQ3", "ENSXETG00000035588", "A0A6I8PW21", "ENSXETG00000032118", "A0A6I8PXQ3", "ENSXETG00000035588", "A0A6I8PW21", "ENSXETG00000032118" ] }, "reaction_10332225": { "compartment": "compartment_984", "id": "reaction_10332225", "reactome": "R-XTR-6783670", "name": "CRLF1 binds CLCF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331527", "species_10331531" ], "products": [ "species_10331533" ], "modifiers": [], "additional_components": [ "F6UWV2", "ENSXETT00000045077", "A0A6I8SGV0", "ENSXETG00000036989", "ENSXETG00000023198", "A0A6I8PWA6", "ENSXETG00000023198", "F6UWV2", "ENSXETT00000045077", "A0A6I8SGV0", "ENSXETG00000036989" ] }, "reaction_10337128": { "compartment": "compartment_70101", "id": "reaction_10337128", "reactome": "R-XTR-9008684", "name": "TBK1 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10320676" ], "products": [ "species_10337126", "species_29370" ], "modifiers": [], "additional_components": [ "ENSXETG00000007322", "ENSXETG00000007322" ] }, "reaction_10327030": { "compartment": "compartment_70101", "id": "reaction_10327030", "reactome": "R-XTR-2730894", "name": "NFKB1:RELA translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313343" ], "products": [ "species_10313349" ], "modifiers": [], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173" ] }, "reaction_10332406": { "compartment": "compartment_17957", "id": "reaction_10332406", "reactome": "R-XTR-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10332404" ], "modifiers": [], "additional_components": [ "ENSXETG00000005359" ] }, "reaction_10332274": { "compartment": "compartment_70101", "id": "reaction_10332274", "reactome": "R-XTR-6785898", "name": "IL4R binds JAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320904", "species_10332270" ], "products": [ "species_10332272" ], "modifiers": [], "additional_components": [ "ENSXETG00000000586", "ENSXETG00000040733", "A0A6I8S2C9", "ENSXETG00000040733", "A0A6I8QZL9", "ENSXETG00000000586" ] }, "reaction_10318525": { "compartment": "compartment_984", "id": "reaction_10318525", "reactome": "R-XTR-448632", "name": "IL34 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318521" ], "products": [ "species_10318523" ], "modifiers": [], "additional_components": [ "ENSXETG00000038235", "A0A6I8QP85", "ENSXETG00000038235" ] }, "reaction_10318556": { "compartment": "compartment_984", "id": "reaction_10318556", "reactome": "R-XTR-449087", "name": "CD4 binds Interleukin-16", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318546", "species_10318552" ], "products": [ "species_10318554" ], "modifiers": [], "additional_components": [ "ENSXETG00000031478", "ENSXETT00000017485", "F7BD23", "ENSXETT00000017485", "A0A6I8SKD0", "ENSXETG00000031478" ] }, "reaction_10337036": { "compartment": "compartment_984", "id": "reaction_10337036", "reactome": "R-XTR-8981657", "name": "IL34 dimer binds PTPRZ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318523", "species_10337032" ], "products": [ "species_10337034" ], "modifiers": [], "additional_components": [ "A0A6I8QP85", "ENSXETG00000038235", "ENSXETG00000022735", "A0A6I8QZW2", "ENSXETG00000022735", "A0A6I8QP85", "ENSXETG00000038235" ] }, "reaction_10318548": { "compartment": "compartment_984", "id": "reaction_10318548", "reactome": "R-XTR-449077", "name": "Interleukin-16 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318541" ], "products": [ "species_10318546" ], "modifiers": [], "additional_components": [ "ENSXETG00000031478", "ENSXETG00000031478" ] }, "reaction_10318544": { "compartment": "compartment_70101", "id": "reaction_10318544", "reactome": "R-XTR-449073", "name": "Caspase-3 cleaves pro-interleukin-16", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318537" ], "products": [ "species_10318539", "species_10318541" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000031478", "ENSXETG00000031478", "ENSXETG00000031478", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10324152": { "compartment": "compartment_70101", "id": "reaction_10324152", "reactome": "R-XTR-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324128", "species_10324148" ], "products": [ "species_10324146", "species_10324150" ], "modifiers": [], "additional_components": [ "A0A6I8S9G6", "ENSXETG00000036095", "A0A6I8QSS2", "ENSXETG00000027885", "A0A6I8SXK0", "ENSXETG00000017287", "Q28ET8", "ENSXETG00000015908", "B7ZTW1", "ENSXETT00000030049", "F6V5S1", "ENSXETT00000039793", "A0A6I8SXK0", "ENSXETG00000017287", "Q28ET8", "ENSXETG00000015908", "B7ZTW1", "ENSXETT00000030049", "F6V5S1", "ENSXETT00000039793", "A0A6I8S9G6", "ENSXETG00000036095", "A0A6I8QSS2", "ENSXETG00000027885" ] }, "reaction_10320256": { "compartment": "compartment_70101", "id": "reaction_10320256", "reactome": "R-XTR-912685", "name": "UBP43 binds IFNAR2 and prevents JAK1 interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320248", "species_10320252" ], "products": [ "species_10320254" ], "modifiers": [], "additional_components": [ "ENSXETG00000038384", "ENSXETG00000034297", "A0A6I8R9K6", "ENSXETG00000034297", "A0A6I8QPM9", "ENSXETG00000038384" ] }, "reaction_10338086": { "compartment": "compartment_70101", "id": "reaction_10338086", "reactome": "R-XTR-9678561", "name": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338082", "species_9678984" ], "products": [ "species_10338084" ], "modifiers": [], "additional_components": [ "A0A6I8QPM9", "ENSXETG00000038384", "A0A6I8PL76", "ENSXETG00000030084", "A0A6I8QZL9", "ENSXETG00000000586", "A0A6I8QPM9", "ENSXETG00000038384", "A0A6I8PL76", "ENSXETG00000030084", "A0A6I8QZL9", "ENSXETG00000000586" ] }, "reaction_10315732": { "compartment": "compartment_70101", "id": "reaction_10315732", "reactome": "R-XTR-202407", "name": "PLC-gamma1 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10315729", "catalyst" ] ], "additional_components": [ "ENSXETG00000003578" ] }, "reaction_10317382": { "compartment": "compartment_70101", "id": "reaction_10317382", "reactome": "R-XTR-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317378", "species_10312717" ], "products": [ "species_10317376", "species_10317380" ], "modifiers": [], "additional_components": [ "A0A6I8T271", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10317356": { "compartment": "compartment_876", "id": "reaction_10317356", "reactome": "R-XTR-389523", "name": "BTLA interacts with HVEM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317348", "species_10317352" ], "products": [ "species_10317354" ], "modifiers": [], "additional_components": [ "ENSXETG00000040606", "ENSXETG00000035588", "A0A6I8PXQ3", "ENSXETG00000035588", "A0A6I8QYL7", "ENSXETG00000040606" ] }, "reaction_10317402": { "compartment": "compartment_70101", "id": "reaction_10317402", "reactome": "R-XTR-389919", "name": "Grb2 binds pBTLA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317398", "species_10312043" ], "products": [ "species_10317400" ], "modifiers": [], "additional_components": [ "A0A6I8PXQ3", "ENSXETG00000035588", "A0A6I8QYL7", "ENSXETG00000040606", "ENSXETT00000027387", "Q66II3", "ENSXETT00000027387", "A0A6I8PXQ3", "ENSXETG00000035588", "A0A6I8QYL7", "ENSXETG00000040606" ] }, "reaction_10338149": { "compartment": "compartment_70101", "id": "reaction_10338149", "reactome": "R-XTR-9690461", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338098", "species_9678991" ], "products": [ "species_10338147" ], "modifiers": [], "additional_components": [ "ENSXETT00000003463", "F7BKJ1", "ENSXETT00000003463" ] }, "reaction_10321852": { "compartment": "compartment_70101", "id": "reaction_10321852", "reactome": "R-XTR-1168633", "name": "NF-kappaB translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321840" ], "products": [ "species_10321850" ], "modifiers": [], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SJP9", "ENSXETG00000002209", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SJP9", "ENSXETG00000002209" ] }, "reaction_10321828": { "compartment": "compartment_70101", "id": "reaction_10321828", "reactome": "R-XTR-1168373", "name": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_10312735", "species_74016" ], "products": [ "species_10312741" ], "modifiers": [], "additional_components": [ "ENSXETG00000017294", "species_114519", "species_33625", "species_74112", "A8KBH6", "ENSXETG00000017294" ] }, "reaction_10316771": { "compartment": "compartment_70101", "id": "reaction_10316771", "reactome": "R-XTR-354173", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10316762" ], "products": [ "species_29420", "species_10316760" ], "modifiers": [ [ "species_10316768", "catalyst" ] ], "additional_components": [ "Q640R7", "ENSXETT00000104159", "species_29420", "Q640R7", "ENSXETT00000104159", "species_29438", "species_74112", "A0A6I8S7H2", "ENSXETG00000040253", "species_114519" ] }, "reaction_10317651": { "compartment": "compartment_70101", "id": "reaction_10317651", "reactome": "R-XTR-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316760" ], "products": [ "species_111294", "species_10316762" ], "modifiers": [ [ "species_10317648", "catalyst" ] ], "additional_components": [ "Q640R7", "ENSXETT00000104159", "species_29438", "Q640R7", "ENSXETT00000104159", "species_29420", "ENSXETG00000034215" ] }, "reaction_10335085": { "compartment": "compartment_876", "id": "reaction_10335085", "reactome": "R-XTR-8852010", "name": "BTNL2 binds activated T cells surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851965", "species_10335081" ], "products": [ "species_10335083" ], "modifiers": [], "additional_components": [ "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889" ] }, "reaction_10334889": { "compartment": "compartment_876", "id": "reaction_10334889", "reactome": "R-XTR-8851018", "name": "BTN2A1 binds DC-SIGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334885", "species_10329899" ], "products": [ "species_10334887" ], "modifiers": [], "additional_components": [ "A0A6I8RCC8", "ENSXETT00000021506", "F7AL17", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8SQD0", "ENSXETG00000030055", "K9J7V7", "ENSXETT00000021506", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "A0A6I8RCC8", "ENSXETT00000021506", "F7AL17", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8SQD0", "ENSXETG00000030055", "K9J7V7", "ENSXETT00000021506" ] }, "reaction_10336232": { "compartment": "compartment_876", "id": "reaction_10336232", "reactome": "R-XTR-8938431", "name": "BTN3A1 and BTN1A1 binds periplakin (PPL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336224", "species_10336228" ], "products": [ "species_10336230" ], "modifiers": [], "additional_components": [ "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506", "ENSXETG00000009137", "A0A6I8RD21", "ENSXETG00000009137", "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506" ] }, "reaction_10334949": { "compartment": "compartment_876", "id": "reaction_10334949", "reactome": "R-XTR-8851038", "name": "BTN3A1 binds prenylated phosphoantigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851032", "species_10334945" ], "products": [ "species_10334947" ], "modifiers": [], "additional_components": [ "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055" ] }, "reaction_10335063": { "compartment": "compartment_876", "id": "reaction_10335063", "reactome": "R-XTR-8851988", "name": "BTN2A2 binds T cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335059", "species_8851965" ], "products": [ "species_10335061" ], "modifiers": [], "additional_components": [ "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506" ] }, "reaction_10335041": { "compartment": "compartment_876", "id": "reaction_10335041", "reactome": "R-XTR-8851979", "name": "BTNL9 binds immune cell surfaces", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851998", "species_10335037" ], "products": [ "species_10335039" ], "modifiers": [], "additional_components": [ "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055" ] }, "reaction_10335107": { "compartment": "compartment_876", "id": "reaction_10335107", "reactome": "R-XTR-8852013", "name": "BTNL8 binds resting T cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851976", "species_10335103" ], "products": [ "species_10335105" ], "modifiers": [], "additional_components": [ "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506" ] }, "reaction_10326539": { "compartment": "compartment_453088", "id": "reaction_10326539", "reactome": "R-XTR-2213239", "name": "Formation of MHC II alpha beta heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326535", "species_10326509" ], "products": [ "species_10326537" ], "modifiers": [], "additional_components": [ "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8PRA1", "ENSXETG00000034043" ] }, "reaction_10326006": { "compartment": "compartment_161320", "id": "reaction_10326006", "reactome": "R-XTR-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10326003", "catalyst" ] ], "additional_components": [ "A0A6I8RUR5", "ENSXETG00000035955", "A0A6I8QK05", "ENSXETG00000027581" ] }, "reaction_10335318": { "compartment": "compartment_876", "id": "reaction_10335318", "reactome": "R-XTR-8856157", "name": "LAG3 (CD233) binds MHC II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335314", "species_10335260" ], "products": [ "species_10335316" ], "modifiers": [], "additional_components": [ "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091", "ENSXETG00000004981", "A0A6I8PSX8", "ENSXETG00000004981", "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091" ] }, "reaction_10326627": { "compartment": "compartment_161320", "id": "reaction_10326627", "reactome": "R-XTR-2213244", "name": "Loading of antigenic peptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213226", "species_10326623" ], "products": [ "species_10326625", "species_10326567" ], "modifiers": [], "additional_components": [ "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8PRA1", "ENSXETG00000034043" ] }, "reaction_10321631": { "compartment": "compartment_13945", "id": "reaction_10321631", "reactome": "R-XTR-983421", "name": "Journey of cargo through Golgi complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321513" ], "products": [ "species_10321629" ], "modifiers": [], "additional_components": [ "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "CHEBI:59080", "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "CHEBI:59080" ] }, "reaction_10321747": { "compartment": "compartment_876", "id": "reaction_10321747", "reactome": "R-XTR-983427", "name": "Expression of peptide bound class I MHC on cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321629" ], "products": [ "species_10314568" ], "modifiers": [], "additional_components": [ "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "CHEBI:59080", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246" ] }, "reaction_10322204": { "compartment": "compartment_1222693", "id": "reaction_10322204", "reactome": "R-XTR-1236965", "name": "Export of peptide loaded MHC class I complex to PM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322202" ], "products": [ "species_10314568" ], "modifiers": [], "additional_components": [ "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246" ] }, "reaction_10322086": { "compartment": "compartment_876", "id": "reaction_10322086", "reactome": "R-XTR-1236964", "name": "Translocation of peptide bound MHC class I complex to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322080" ], "products": [ "species_10314568" ], "modifiers": [], "additional_components": [ "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246", "species_1236727", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246" ] }, "reaction_10322082": { "compartment": "compartment_171043", "id": "reaction_10322082", "reactome": "R-XTR-1236943", "name": "Loading of antigen peptide onto MHC class I molecule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236727", "species_10322078" ], "products": [ "species_10322080" ], "modifiers": [], "additional_components": [ "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246", "species_1236727" ] }, "reaction_10321964": { "compartment": "compartment_24339", "id": "reaction_10321964", "reactome": "R-XTR-1236941", "name": "Internalization of receptor bound antigen into clathrin coted vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321942" ], "products": [ "species_10321962" ], "modifiers": [], "additional_components": [ "species_1236715", "L7N3D8", "ENSXETT00000028489", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "species_1236715", "L7N3D8", "ENSXETT00000028489", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813" ] }, "reaction_10322084": { "compartment": "compartment_24339", "id": "reaction_10322084", "reactome": "R-XTR-1236955", "name": "Movement of clathrin coated vesicles into early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321962" ], "products": [ "species_10321920" ], "modifiers": [], "additional_components": [ "species_1236715", "L7N3D8", "ENSXETT00000028489", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "L7N3D8", "ENSXETT00000028489", "species_1236715" ] }, "reaction_10321922": { "compartment": "compartment_171043", "id": "reaction_10321922", "reactome": "R-XTR-1236940", "name": "Exogenous soluble antigen targeted to more stable early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321920" ], "products": [ "species_1236715", "species_10321918" ], "modifiers": [], "additional_components": [ "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "L7N3D8", "ENSXETT00000028489", "species_1236715", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "L7N3D8", "ENSXETT00000028489" ] }, "reaction_10321357": { "compartment": "compartment_70101", "id": "reaction_10321357", "reactome": "R-XTR-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321345", "species_113592", "species_10321339" ], "products": [ "species_111294", "species_10321352", "species_10321337", "species_76577" ], "modifiers": [ [ "species_10321345", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "Q6GL05", "ENSXETT00000101990", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "Q6GL05", "ENSXETT00000101990", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608" ] }, "reaction_10321359": { "compartment": "compartment_70101", "id": "reaction_10321359", "reactome": "R-XTR-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321281", "species_10321339", "species_983035" ], "products": [ "species_10321341" ], "modifiers": [], "additional_components": [ "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "Q6GL05", "ENSXETT00000101990", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q6GL05", "ENSXETT00000101990", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608" ] }, "reaction_10321354": { "compartment": "compartment_70101", "id": "reaction_10321354", "reactome": "R-XTR-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321352" ], "products": [ "species_10321281", "species_983123" ], "modifiers": [], "additional_components": [ "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608" ] }, "reaction_10321348": { "compartment": "compartment_70101", "id": "reaction_10321348", "reactome": "R-XTR-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10321341" ], "products": [ "species_111294", "species_10321345", "species_10321337", "species_76577" ], "modifiers": [ [ "species_10321281", "catalyst" ] ], "additional_components": [ "Q6GL05", "ENSXETT00000101990", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "Q6GL05", "ENSXETT00000101990", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608" ] }, "reaction_10334525": { "compartment": "compartment_984", "id": "reaction_10334525", "reactome": "R-XTR-6807585", "name": "BPI binds LPS on the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10313204" ], "products": [ "species_10334523" ], "modifiers": [], "additional_components": [ "ENSXETG00000017331", "A0A6I8REW5", "ENSXETG00000017331", "species_166005" ] }, "reaction_10333951": { "compartment": "compartment_984", "id": "reaction_10333951", "reactome": "R-XTR-6801762", "name": "REG3A oligomerize to form a pore complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333945" ], "products": [ "species_10333949" ], "modifiers": [ [ "species_166005", "inhibitor" ] ], "additional_components": [ "CHEBI:62643", "A0A6I8PQ14", "ENSXETG00000033383", "CHEBI:62643", "A0A6I8PQ14", "ENSXETG00000033383" ] }, "reaction_10321873": { "compartment": "compartment_1222282", "id": "reaction_10321873", "reactome": "R-XTR-1222491", "name": "Lactoferrin scavenges iron ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2101051", "species_1222611", "species_10321869" ], "products": [ "species_10321871" ], "modifiers": [], "additional_components": [ "ENSXETG00000011814", "Q501K5", "ENSXETG00000011814", "species_912516", "species_2101051" ] }, "reaction_10333978": { "compartment": "compartment_984", "id": "reaction_10333978", "reactome": "R-XTR-6803063", "name": "RNASEs bind bacterial LPS, PGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333974", "species_6803074" ], "products": [ "species_10333976" ], "modifiers": [], "additional_components": [ "A0A6I8R6T7", "ENSXETG00000038487", "CHEBI:55478", "species_6789198", "species_166005", "CHEBI:55478", "species_6789198", "species_166005", "A0A6I8R6T7", "ENSXETG00000038487" ] }, "reaction_10334646": { "compartment": "compartment_984", "id": "reaction_10334646", "reactome": "R-XTR-6813659", "name": "ELANE, CTSG or PRTN3 binds bacteria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334642", "species_8879165" ], "products": [ "species_10334644" ], "modifiers": [], "additional_components": [ "A0A6I8RBC3", "ENSXETG00000037351", "Q5HZU5", "ENSXETT00000093455", "A0A6I8QPJ5", "ENSXETG00000039590", "F7EHU5", "ENSXETT00000037000", "A0A6I8RBC3", "ENSXETG00000037351", "Q5HZU5", "ENSXETT00000093455", "A0A6I8QPJ5", "ENSXETG00000039590", "F7EHU5", "ENSXETT00000037000" ] }, "reaction_10334033": { "compartment": "compartment_984", "id": "reaction_10334033", "reactome": "R-XTR-6804527", "name": "INTL1 binds bacterial glycans", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334029", "species_6804535" ], "products": [ "species_10334031" ], "modifiers": [], "additional_components": [ "species_74112", "F7BS21", "ENSXETT00000047100", "CHEBI:42976", "CHEBI:59496", "CHEBI:85986", "CHEBI:42976", "CHEBI:59496", "CHEBI:85986", "species_74112", "F7BS21", "ENSXETT00000047100" ] }, "reaction_10334640": { "compartment": "compartment_984", "id": "reaction_10334640", "reactome": "R-XTR-6813626", "name": "LEAP2 binds bacteria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334636", "species_8931784" ], "products": [ "species_10334638" ], "modifiers": [], "additional_components": [ "ENSXETG00000030080", "CHEBI:62643", "CHEBI:62643", "A0A6I8QY26", "ENSXETG00000030080" ] }, "reaction_10333966": { "compartment": "compartment_984", "id": "reaction_10333966", "reactome": "R-XTR-6801808", "name": "REG3A,REG3G binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333943", "species_6789198" ], "products": [ "species_10333964" ], "modifiers": [], "additional_components": [ "ENSXETG00000033383", "species_6789198", "A0A6I8PQ14", "ENSXETG00000033383" ] }, "reaction_10333960": { "compartment": "compartment_984", "id": "reaction_10333960", "reactome": "R-XTR-6801766", "name": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333953" ], "products": [ "species_10333955", "species_10333943" ], "modifiers": [ [ "species_10333957", "catalyst" ] ], "additional_components": [ "ENSXETG00000033383", "ENSXETG00000033383", "ENSXETG00000033383", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148" ] }, "reaction_10336840": { "compartment": "compartment_984", "id": "reaction_10336840", "reactome": "R-XTR-8948027", "name": "RNASEs bind bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333974", "species_8931784" ], "products": [ "species_10336838" ], "modifiers": [], "additional_components": [ "A0A6I8R6T7", "ENSXETG00000038487", "CHEBI:62643", "CHEBI:62643", "A0A6I8R6T7", "ENSXETG00000038487" ] }, "reaction_10333962": { "compartment": "compartment_984", "id": "reaction_10333962", "reactome": "R-XTR-6801776", "name": "REG3A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333943", "species_8931784" ], "products": [ "species_10333945" ], "modifiers": [], "additional_components": [ "ENSXETG00000033383", "CHEBI:62643", "CHEBI:62643", "A0A6I8PQ14", "ENSXETG00000033383" ] }, "reaction_10335621": { "compartment": "compartment_984", "id": "reaction_10335621", "reactome": "R-XTR-8862320", "name": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10335616" ], "products": [ "species_6788991", "species_6788982" ], "modifiers": [ [ "species_10335616", "catalyst" ] ], "additional_components": [ "A0A6I8RID5", "ENSXETG00000037293", "species_6789198", "species_1236715", "CHEBI:21615", "A0A6I8RID5", "ENSXETG00000037293", "species_6789198" ] }, "reaction_10334628": { "compartment": "compartment_984", "id": "reaction_10334628", "reactome": "R-XTR-6810724", "name": "PI3 binds the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10334624" ], "products": [ "species_10334626" ], "modifiers": [], "additional_components": [ "A0A6I8RZ58", "ENSXETG00000038864", "A0A6I8QJ14", "ENSXETG00000036342", "A0A6I8RZ58", "ENSXETG00000038864", "A0A6I8QJ14", "ENSXETG00000036342", "species_166005" ] }, "reaction_10333638": { "compartment": "compartment_984", "id": "reaction_10333638", "reactome": "R-XTR-6799959", "name": "PGLYRP3,4 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333634", "species_6789198" ], "products": [ "species_10333636" ], "modifiers": [ [ "species_158417", "catalyst" ] ], "additional_components": [ "Q5BKE6", "ENSXETT00000089406", "species_6789198", "Q5BKE6", "ENSXETT00000089406" ] }, "reaction_10332387": { "compartment": "compartment_1222282", "id": "reaction_10332387", "reactome": "R-XTR-6789072", "name": "PGLYRP1 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10332383" ], "products": [ "species_10332385" ], "modifiers": [ [ "species_1562550", "catalyst" ] ], "additional_components": [ "Q5BKE6", "ENSXETT00000089406", "Q5BKE6", "ENSXETT00000089406", "species_6789198" ] }, "reaction_10335618": { "compartment": "compartment_984", "id": "reaction_10335618", "reactome": "R-XTR-8862300", "name": "LYZ binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10332888" ], "products": [ "species_10335616" ], "modifiers": [], "additional_components": [ "ENSXETG00000037293", "A0A6I8RID5", "ENSXETG00000037293", "species_6789198" ] }, "reaction_10327260": { "compartment": "compartment_12045", "id": "reaction_10327260", "reactome": "R-XTR-3134800", "name": "STING dimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324507" ], "products": [ "species_10326753" ], "modifiers": [ [ "species_10327258", "catalyst" ] ], "additional_components": [ "ENSXETG00000016088", "A8E5V9", "ENSXETG00000016088", "ENSXETG00000016088" ] }, "reaction_10327352": { "compartment": "compartment_12045", "id": "reaction_10327352", "reactome": "R-XTR-3244643", "name": "STING binds cyclic GMP-AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326753", "species_3244587" ], "products": [ "species_10327350" ], "modifiers": [], "additional_components": [ "A8E5V9", "ENSXETG00000016088", "species_3244587", "A8E5V9", "ENSXETG00000016088" ] }, "reaction_10326762": { "compartment": "compartment_12045", "id": "reaction_10326762", "reactome": "R-XTR-2396009", "name": "STING binds c-di-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326753", "species_2395973" ], "products": [ "species_10326760" ], "modifiers": [], "additional_components": [ "A8E5V9", "ENSXETG00000016088", "species_2395973", "A8E5V9", "ENSXETG00000016088" ] }, "reaction_10337738": { "compartment": "compartment_70101", "id": "reaction_10337738", "reactome": "R-XTR-9604480", "name": "NFkB complex translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313343" ], "products": [ "species_10313349" ], "modifiers": [], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173" ] }, "reaction_10329903": { "compartment": "compartment_876", "id": "reaction_10329903", "reactome": "R-XTR-5621571", "name": "CD209 binds ICAM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314660", "species_10329899" ], "products": [ "species_10329901" ], "modifiers": [], "additional_components": [ "A0A6I8PWA4", "ENSXETG00000027690", "A0A6I8Q7U5", "ENSXETG00000022064", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "A0A6I8PWA4", "ENSXETG00000027690", "A0A6I8Q7U5", "ENSXETG00000022064" ] }, "reaction_10330318": { "compartment": "compartment_7660", "id": "reaction_10330318", "reactome": "R-XTR-5660980", "name": "p-S276-RELA binds RELB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330314", "species_10329932" ], "products": [ "species_10330316" ], "modifiers": [], "additional_components": [ "ENSXETG00000031521", "ENSXETG00000026173", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8PZ90", "ENSXETG00000031521" ] }, "reaction_10329907": { "compartment": "compartment_876", "id": "reaction_10329907", "reactome": "R-XTR-5621615", "name": "CD209 binds ICAM3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314666", "species_10329899", "species_74112" ], "products": [ "species_10329905" ], "modifiers": [], "additional_components": [ "A0A6I8Q7U5", "ENSXETG00000022064", "A0A6I8PWA4", "ENSXETG00000027690", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "species_74112", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "A0A6I8Q7U5", "ENSXETG00000022064", "A0A6I8PWA4", "ENSXETG00000027690" ] }, "reaction_10329834": { "compartment": "compartment_876", "id": "reaction_10329834", "reactome": "R-XTR-5607755", "name": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329832" ], "products": [ "species_10329827" ], "modifiers": [], "additional_components": [ "ENSXETG00000003578", "ENSXETG00000003578" ] }, "reaction_10329830": { "compartment": "compartment_876", "id": "reaction_10329830", "reactome": "R-XTR-5607735", "name": "p-Y753,Y759-PLCG2 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10329827", "catalyst" ] ], "additional_components": [ "ENSXETG00000003578" ] }, "reaction_10335614": { "compartment": "compartment_876", "id": "reaction_10335614", "reactome": "R-XTR-8858500", "name": "CLEC10A binds Tn-MUC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335610", "species_10335598" ], "products": [ "species_10335612" ], "modifiers": [], "additional_components": [ "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "ENSXETG00000041320", "A0A6I8Q6M7", "ENSXETG00000041320", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522" ] }, "reaction_10332377": { "compartment": "compartment_70101", "id": "reaction_10332377", "reactome": "R-XTR-6788999", "name": "HV1-mediated H+ transfer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10332374", "catalyst" ] ], "additional_components": [ "Q5M8L8", "ENSXETT00000045238" ] }, "reaction_10317728": { "compartment": "compartment_70101", "id": "reaction_10317728", "reactome": "R-XTR-418436", "name": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10315942", "catalyst" ] ], "additional_components": [ "ENSXETG00000011979" ] }, "reaction_10313407": { "compartment": "compartment_984", "id": "reaction_10313407", "reactome": "R-XTR-169719", "name": "Secreted CD14 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313202", "species_10313403" ], "products": [ "species_10313200", "species_10313405" ], "modifiers": [], "additional_components": [ "species_166005", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "ENSXETG00000031516", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "A0A6I8PVH6", "ENSXETG00000031516", "species_166005" ] }, "reaction_10313216": { "compartment": "compartment_984", "id": "reaction_10313216", "reactome": "R-XTR-166038", "name": "GPI-bound CD14 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313202", "species_10313212" ], "products": [ "species_10313200", "species_10313214" ], "modifiers": [], "additional_components": [ "species_166005", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "ENSXETG00000031516", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "A0A6I8PVH6", "ENSXETG00000031516", "species_166005" ] }, "reaction_10326889": { "compartment": "compartment_876", "id": "reaction_10326889", "reactome": "R-XTR-2559456", "name": "TIRAP binds PIP2-rich regions in the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326885", "species_179856" ], "products": [ "species_10326887" ], "modifiers": [], "additional_components": [ "ENSXETG00000031764", "species_179856", "A0A6I8QHE1", "ENSXETG00000031764" ] }, "reaction_10313206": { "compartment": "compartment_984", "id": "reaction_10313206", "reactome": "R-XTR-166015", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313200", "species_166005" ], "products": [ "species_10313202" ], "modifiers": [ [ "species_10313204", "inhibitor" ] ], "additional_components": [ "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "species_166005", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "ENSXETG00000017331" ] }, "reaction_10335885": { "compartment": "compartment_984", "id": "reaction_10335885", "reactome": "R-XTR-8869694", "name": "oxPL binds CD14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2186967", "species_10313403" ], "products": [ "species_10335883" ], "modifiers": [], "additional_components": [ "ENSXETG00000031516", "A0A6I8PVH6", "ENSXETG00000031516", "species_2186967" ] }, "reaction_10335881": { "compartment": "compartment_984", "id": "reaction_10335881", "reactome": "R-XTR-8869683", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313200", "species_2186967" ], "products": [ "species_10335879" ], "modifiers": [], "additional_components": [ "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "species_2186967", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015" ] }, "reaction_10313401": { "compartment": "compartment_984", "id": "reaction_10313401", "reactome": "R-XTR-168947", "name": "Ligand binds to TLR10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313395", "species_168948" ], "products": [ "species_10313399" ], "modifiers": [], "additional_components": [ "ENSXETG00000018477", "A0A6I8PMY8", "ENSXETG00000018477" ] }, "reaction_10324331": { "compartment": "compartment_876", "id": "reaction_10324331", "reactome": "R-XTR-1861621", "name": "Cross-linking of FCGRIIA with IgG-coated Ag", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324321", "species_10324327" ], "products": [ "species_10324329" ], "modifiers": [], "additional_components": [ "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8QLS0", "ENSXETG00000041230", "A0A6I8QM25", "ENSXETG00000041230", "A0A6I8PTS9", "ENSXETG00000041230", "A0A6I8RSN1", "ENSXETG00000041230", "A0A6I8PUH7", "ENSXETG00000041230", "A0A6I8S9Z8", "ENSXETG00000041230", "A0A6I8PM56", "ENSXETG00000041230", "A0A6I8RJH0", "ENSXETG00000041230", "A0A6I8PMK7", "ENSXETG00000041230", "A0A6I8RS78", "ENSXETG00000041230", "A0A6I8R4R2", "ENSXETG00000041230", "A0A6I8R767", "ENSXETG00000041230", "A0A6I8RSK9", "ENSXETG00000040383", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212", 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"A0A6I8R2N8", "ENSXETT00000069302", "A0A6I8R7C6", "ENSXETT00000069302", "A0A6I8QNF8", "ENSXETT00000069302", "A0A6I8QSF1", "ENSXETT00000069302", "A0A6I8QE50", "ENSXETT00000069302", "A0A6I8QMZ7", "ENSXETT00000069302", "A0A6I8Q652", "ENSXETT00000069302", "A0A6I8Q664", "ENSXETT00000069302", "A0A6I8Q2X0", "ENSXETT00000069302", "A0A6I8Q318", "ENSXETT00000069302", "A0A6I8Q0S1", "ENSXETT00000069302", "A0A6I8Q2I9", "ENSXETT00000069302", "K9J7P7", "ENSXETT00000007797", "A0A6I8PSU3", "ENSXETG00000039428", "F6S2S6", "ENSXETT00000022997", "A0A6I8Q2V3", "ENSXETG00000039428", "A0A6I8RZZ7", "ENSXETG00000039428", "A0A6I8SEP6", "ENSXETG00000039428", "A0A6I8QNA7", "ENSXETG00000039428", "A0A6I8R2R2", "ENSXETG00000039428", "A0A6I8Q7C1", "ENSXETG00000039428", "A0A6I8QD99", "ENSXETG00000039428", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8QLS0", "ENSXETG00000041230", "A0A6I8QM25", "ENSXETG00000041230", "A0A6I8PTS9", "ENSXETG00000041230", "A0A6I8RSN1", "ENSXETG00000041230", "A0A6I8PUH7", "ENSXETG00000041230", "A0A6I8S9Z8", "ENSXETG00000041230", "A0A6I8PM56", "ENSXETG00000041230", "A0A6I8RJH0", "ENSXETG00000041230", "A0A6I8PMK7", "ENSXETG00000041230", "A0A6I8RS78", "ENSXETG00000041230", "A0A6I8R4R2", "ENSXETG00000041230", "A0A6I8R767", "ENSXETG00000041230", "A0A6I8RSK9", "ENSXETG00000040383", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212", "A0A6I8SK71", "ENSXETG00000040212", "A0A6I8QZL1", "ENSXETG00000040212", "A0A6I8RUJ4", "ENSXETG00000040212", "A0A6I8QKP4", "ENSXETG00000040212", "A0A6I8RNX1", "ENSXETG00000040212", "A0A6I8SYV6", "ENSXETG00000040212", "A0A6I8PWK1", "ENSXETT00000069302", "A0A6I8PXL5", "ENSXETT00000069302", "A0A5G3K4A2", "ENSXETT00000069302", "F7ATU6", "ENSXETT00000069302", "A0A6I8PNW8", "ENSXETT00000069302", "L7N2W1", "ENSXETT00000013311", "A0A6I8SSF0", "ENSXETT00000069302", "A0A6I8SYX6", "ENSXETT00000069302", "A0A6I8SF25", "ENSXETT00000069302", "A0A6I8SJ82", "ENSXETT00000069302", "A0A6I8SCS2", "ENSXETT00000069302", "A0A6I8SCZ9", "ENSXETT00000069302", "A0A6I8S4K2", "ENSXETT00000069302", "A0A6I8S824", "ENSXETT00000069302", "A0A6I8S1H6", "ENSXETT00000069302", "A0A6I8S3H5", "ENSXETT00000069302", "A0A6I8RTG9", "ENSXETT00000069302", "A0A6I8RYE0", "ENSXETT00000069302", "A0A6I8RLS5", "ENSXETT00000069302", "A0A6I8RQ73", "ENSXETT00000069302", "A0A6I8RDF6", "ENSXETT00000069302", "A0A6I8RF32", "ENSXETT00000069302", "A0A6I8R2N8", "ENSXETT00000069302", "A0A6I8R7C6", "ENSXETT00000069302", "A0A6I8QNF8", "ENSXETT00000069302", "A0A6I8QSF1", "ENSXETT00000069302", "A0A6I8QE50", "ENSXETT00000069302", "A0A6I8QMZ7", "ENSXETT00000069302", "A0A6I8Q652", "ENSXETT00000069302", "A0A6I8Q664", "ENSXETT00000069302", "A0A6I8Q2X0", "ENSXETT00000069302", "A0A6I8Q318", "ENSXETT00000069302", "A0A6I8Q0S1", "ENSXETT00000069302", "A0A6I8Q2I9", "ENSXETT00000069302", "K9J7P7", "ENSXETT00000007797", "A0A6I8PSU3", "ENSXETG00000039428", "F6S2S6", "ENSXETT00000022997", "A0A6I8Q2V3", "ENSXETG00000039428", "A0A6I8RZZ7", "ENSXETG00000039428", "A0A6I8SEP6", "ENSXETG00000039428", "A0A6I8QNA7", "ENSXETG00000039428", "A0A6I8R2R2", "ENSXETG00000039428", "A0A6I8Q7C1", "ENSXETG00000039428", "A0A6I8QD99", "ENSXETG00000039428" ] }, "reaction_10326828": { "compartment": "compartment_876", "id": "reaction_10326828", "reactome": "R-XTR-2426569", "name": "Interaction of DAP12 and IREM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326824", "species_10316092" ], "products": [ "species_10326826" ], "modifiers": [], "additional_components": [ "ENSXETG00000036363", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8SNS8", "ENSXETG00000036363" ] }, "reaction_10316104": { "compartment": "compartment_876", "id": "reaction_10316104", "reactome": "R-XTR-210300", "name": "Interaction of DAP12 and TREM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316100", "species_10316092" ], "products": [ "species_10316102" ], "modifiers": [], "additional_components": [ "ENSXETG00000037809", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QSY3", "ENSXETG00000037809" ] }, "reaction_10326264": { "compartment": "compartment_876", "id": "reaction_10326264", "reactome": "R-XTR-2172123", "name": "Interaction of SIGLEC14/15/16 and DAP12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326260", "species_10316092" ], "products": [ "species_10326262" ], "modifiers": [], "additional_components": [ "A0A6I8Q2E3", "ENSXETG00000031297", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8Q2E3", "ENSXETG00000031297", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970" ] }, "reaction_10326651": { "compartment": "compartment_876", "id": "reaction_10326651", "reactome": "R-XTR-2272668", "name": "Interaction of DAP12 and KIR2DS5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315610", "species_10316092" ], "products": [ "species_10326649" ], "modifiers": [], "additional_components": [ "ENSXETG00000032630", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8Q0D7", "ENSXETG00000032630" ] }, "reaction_10325991": { "compartment": "compartment_876", "id": "reaction_10325991", "reactome": "R-XTR-2130151", "name": "Dimerization of DAP12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315608" ], "products": [ "species_10316092" ], "modifiers": [], "additional_components": [ "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786" ] }, "reaction_10326822": { "compartment": "compartment_876", "id": "reaction_10326822", "reactome": "R-XTR-2426566", "name": "Interaction of DAP12 and CLM7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326818", "species_10316092" ], "products": [ "species_10326820" ], "modifiers": [], "additional_components": [ "ENSXETG00000036363", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8SNS8", "ENSXETG00000036363" ] }, "reaction_10316096": { "compartment": "compartment_876", "id": "reaction_10316096", "reactome": "R-XTR-210273", "name": "Interaction of DAP12 and NKp44", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316090", "species_10316092" ], "products": [ "species_10316094" ], "modifiers": [], "additional_components": [ "ENSXETG00000032041", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8PSB6", "ENSXETG00000032041" ] }, "reaction_10320644": { "compartment": "compartment_17906", "id": "reaction_10320644", "reactome": "R-XTR-936564", "name": "NLRX1 inhibits MAVS-DDX58 interaction.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320640", "species_10320636" ], "products": [ "species_10320642" ], "modifiers": [], "additional_components": [ "ENSXETG00000021586", "ENSXETG00000032111", "A0A6I8PQE8", "ENSXETG00000032111", "A0A6I8PYZ4", "ENSXETG00000021586" ] }, "reaction_10338275": { "compartment": "compartment_17906", "id": "reaction_10338275", "reactome": "R-XTR-9709842", "name": "MAVS binds TOMM70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331987", "species_10320636" ], "products": [ "species_10338273" ], "modifiers": [], "additional_components": [ "ENSXETG00000011867", "ENSXETG00000032111", "A0A6I8PQE8", "ENSXETG00000032111", "A0A6I8QP49", "ENSXETG00000011867" ] }, "reaction_10333758": { "compartment": "compartment_6800424", "id": "reaction_10333758", "reactome": "R-XTR-6800426", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333750" ], "products": [ "species_10333756" ], "modifiers": [], "additional_components": [ "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8PUI6", "ENSXETG00000037491", "A0A6I8QHU4", "ENSXETG00000015523", "A0A6I8SNS8", "ENSXETG00000036363", "Q6P2W7", "ENSXETG00000024963", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "Q6GL60", "ENSXETT00000092508", "A0A6I8SYN8", "ENSXETG00000035544", "A0A6I8Q475", "ENSXETG00000035544", "A0A6I8PQG1", "ENSXETG00000034243", "A0A6I8QZT4", "ENSXETG00000015766", "F6WCE6", "ENSXETT00000002749", "Q6NVR9", "ENSXETT00000028394", "A0A6I8SS44", "ENSXETG00000034408", "A1A5G6", "ENSXETG00000007635", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q632", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "Q0VA77", "ENSXETT00000035499", "Q6P8C8", "ENSXETT00000001981", "F6WSE4", "ENSXETT00000003359", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8PQG1", "ENSXETG00000034243", "Q0VA77", "ENSXETT00000035499", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8Q632", "ENSXETG00000041332", "A0A6I8QZT4", "ENSXETG00000015766", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8QHU4", "ENSXETG00000015523", "Q6P2W7", "ENSXETG00000024963", "A0A6I8Q475", "ENSXETG00000035544", "A0A6I8SYN8", "ENSXETG00000035544", "Q6P8C8", "ENSXETT00000001981", "F6WCE6", "ENSXETT00000002749", "Q6NVR9", "ENSXETT00000028394", "Q6GL60", "ENSXETT00000092508", "A1A5G6", "ENSXETG00000007635", "F6WSE4", "ENSXETT00000003359", "A0A6I8SS44", "ENSXETG00000034408", "A0A6I8SNS8", "ENSXETG00000036363", "A0A6I8PUI6", "ENSXETG00000037491" ] }, "reaction_10333460": { "compartment": "compartment_1470028", "id": "reaction_10333460", "reactome": "R-XTR-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333416" ], "products": [ "species_10333458" ], "modifiers": [], "additional_components": [ "Q6DIW0", "ENSXETT00000053781", "A0A6I8PNH6", "ENSXETG00000034056", "A4QNN7", "ENSXETT00000010246", "A0A6I8Q3I4", "ENSXETG00000032992", "Q6GLE7", "ENSXETT00000052187", "Q28FE0", "ENSXETT00000019617", "F6SF13", "ENSXETT00000019894", "F7EHU5", "ENSXETT00000037000", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8Q1T5", "ENSXETG00000014900", "A0A6I8T0D3", "ENSXETG00000001184", "F6YPC2", "ENSXETT00000038130", "A0A6I8S033", "ENSXETG00000009423", "A0A6I8QUN5", "ENSXETG00000039169", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "A0A6I8QPJ5", "ENSXETG00000039590", "A0A6I8RBC3", "ENSXETG00000037351", "Q5HZU5", "ENSXETT00000093455", "Q5BL41", "ENSXETT00000030571", "A0A6I8RID5", "ENSXETG00000037293", "A0A6I8QAR5", "ENSXETG00000003287", "Q6P4K6", "ENSXETG00000007155", "A0A6I8PSL2", "ENSXETG00000026399", "F6T7W4", "ENSXETT00000045926", "F7DYP1", "ENSXETT00000013582", "Q28BP9", "ENSXETG00000010945", "L7N3U2", "ENSXETT00000047429", "A0A6I8R6T7", "ENSXETG00000038487", "Q6DFR0", "ENSXETT00000010030", "Q6GL04", "ENSXETT00000067185", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "A0A6I8RID5", "ENSXETG00000037293", "A0A6I8QUN5", "ENSXETG00000039169", "L7N3U2", "ENSXETT00000047429", "A0A6I8Q3I4", "ENSXETG00000032992", "Q6GLE7", "ENSXETT00000052187", "Q6DIW0", "ENSXETT00000053781", "A0A6I8S033", "ENSXETG00000009423", "A0A6I8Q1T5", "ENSXETG00000014900", "F6SF13", "ENSXETT00000019894", "Q6P4K6", "ENSXETG00000007155", "F6YPC2", "ENSXETT00000038130", "A0A6I8QPJ5", "ENSXETG00000039590", "A0A6I8RBC3", "ENSXETG00000037351", "Q5HZU5", "ENSXETT00000093455", "F6T7W4", "ENSXETT00000045926", "F7DYP1", "ENSXETT00000013582", "A0A6I8PSL2", "ENSXETG00000026399", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8R6T7", "ENSXETG00000038487", "A4QNN7", "ENSXETT00000010246", "Q28BP9", "ENSXETG00000010945", "A0A6I8PNH6", "ENSXETG00000034056", "Q6DFR0", "ENSXETT00000010030", "A0A6I8T0D3", "ENSXETG00000001184", "Q28FE0", "ENSXETT00000019617", "A0A6I8QAR5", "ENSXETG00000003287", "F7EHU5", "ENSXETT00000037000", "Q5BL41", "ENSXETT00000030571", "Q6GL04", "ENSXETT00000067185" ] }, "reaction_10332598": { "compartment": "compartment_6798757", "id": "reaction_10332598", "reactome": "R-XTR-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10332572" ], "products": [ "species_10332596" ], "modifiers": [], "additional_components": [ "B1H3C9", "ENSXETG00000019826", "A0A6I8R329", "ENSXETG00000038658", "A0A6I8SB02", "ENSXETG00000038658", "A0A6I8PPZ5", "ENSXETG00000038658", "A0A6I8QZM7", "ENSXETG00000032631", "Q6P8C8", "ENSXETT00000001981", "Q640R7", "ENSXETT00000104159", "A0A1B8Y5B7", "ENSXETT00000104043", "F6WCE6", "ENSXETT00000002749", "A0A6I8RRU8", "ENSXETG00000035335", "Q6P2W7", "ENSXETG00000024963", "A0A6I8SFY1", "ENSXETG00000002247", "A0A6I8PML7", "ENSXETG00000027247", "A0A6I8QSY3", "ENSXETG00000037809", "F7AHQ1", "ENSXETT00000007782", "F6PX96", "ENSXETT00000016673", "F6ULZ5", "ENSXETT00000023447", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8Q632", "ENSXETG00000041332", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8SFY1", "ENSXETG00000002247", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8Q632", "ENSXETG00000041332", "A0A6I8R329", "ENSXETG00000038658", "A0A6I8PPZ5", "ENSXETG00000038658", "A0A6I8QZM7", "ENSXETG00000032631", "A0A6I8SB02", "ENSXETG00000038658", "Q640R7", "ENSXETT00000104159", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "F6ULZ5", "ENSXETT00000023447", "Q6P2W7", "ENSXETG00000024963", "A0A1B8Y5B7", "ENSXETT00000104043", "Q6P8C8", "ENSXETT00000001981", "F6WCE6", "ENSXETT00000002749", "A0A6I8RRU8", "ENSXETG00000035335", "F7AHQ1", "ENSXETT00000007782", "F6PX96", "ENSXETT00000016673", "A0A6I8PML7", "ENSXETG00000027247", "B1H3C9", "ENSXETG00000019826", "A0A6I8QSY3", "ENSXETG00000037809" ] }, "reaction_10333222": { "compartment": "compartment_1462052", "id": "reaction_10333222", "reactome": "R-XTR-6798748", "name": "Exocytosis of secretory granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333156" ], "products": [ "species_10333220" ], "modifiers": [], "additional_components": [ "Q6DEU1", "ENSXETT00000058038", "Q6P326", "ENSXETG00000021646", "A0A6I8Q5Z6", "ENSXETG00000031325", "A0A6I8SM68", "ENSXETG00000032580", "A0A6I8RCL3", "ENSXETG00000006695", "F7B3J1", "ENSXETT00000011348", "A0A6I8R1G6", "ENSXETG00000007490", "A0A6I8QYH5", "ENSXETG00000035070", "A0A6I8SRS9", "ENSXETG00000016932", "A0A6I8Q0D7", "ENSXETG00000032630", "Q28IX9", "ENSXETT00000096095", "A0A6I8QJX8", "ENSXETG00000010896", "L7N2L6", "ENSXETT00000005874", "A0A6I8S033", "ENSXETG00000009423", "A0A6I8SJ17", "ENSXETG00000016072", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8RMU5", "ENSXETG00000041054", "A0A6I8QYQ6", "ENSXETG00000037779", "A0A6I8RU72", "ENSXETG00000041054", "A0A6I8RSU0", "ENSXETG00000041054", "A0A6I8QAR5", "ENSXETG00000003287", "Q6GL04", "ENSXETT00000067185", "A0A6I8SZP6", "ENSXETG00000021325", "F6TGE8", "ENSXETT00000000571", "A0A6I8SR75", "ENSXETG00000037123", "A0A6I8SKX0", "ENSXETG00000018552", "A0A6I8RTF4", "ENSXETG00000038059", "F7BED4", "ENSXETT00000050679", "A0A6I8RKW5", "ENSXETG00000019013", "Q4V9Y5", "ENSXETT00000029363", "A0A6I8SN57", "ENSXETG00000037611", "A0A6I8QFG6", "ENSXETG00000037805", "Q5I0S8", "ENSXETT00000001376", "A0A6I8Q5Z6", "ENSXETG00000031325", "A0A6I8SRS9", "ENSXETG00000016932", "F7B3J1", "ENSXETT00000011348", "A0A6I8RKW5", "ENSXETG00000019013", "A0A6I8QJX8", "ENSXETG00000010896", "L7N2L6", "ENSXETT00000005874", "A0A6I8RSU0", "ENSXETG00000041054", "A0A6I8RU72", "ENSXETG00000041054", "A0A6I8QYQ6", "ENSXETG00000037779", "A0A6I8RMU5", "ENSXETG00000041054", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8SJ17", "ENSXETG00000016072", "A0A6I8SN57", "ENSXETG00000037611", "A0A6I8S033", "ENSXETG00000009423", "A0A6I8RTF4", "ENSXETG00000038059", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8SR75", "ENSXETG00000037123", "Q4V9Y5", "ENSXETT00000029363", "F7BED4", "ENSXETT00000050679", "A0A6I8QFG6", "ENSXETG00000037805", "A0A6I8SM68", "ENSXETG00000032580", "Q6DEU1", "ENSXETT00000058038", "Q6P326", "ENSXETG00000021646", "A0A6I8RCL3", "ENSXETG00000006695", "A0A6I8R1G6", "ENSXETG00000007490", "Q28IX9", "ENSXETT00000096095", "A0A6I8QYH5", "ENSXETG00000035070", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8QAR5", "ENSXETG00000003287", "F6TGE8", "ENSXETT00000000571", "Q6GL04", "ENSXETT00000067185", "A0A6I8SKX0", "ENSXETG00000018552", "Q5I0S8", "ENSXETT00000001376" ] }, "reaction_10333312": { "compartment": "compartment_6799371", "id": "reaction_10333312", "reactome": "R-XTR-6798749", "name": "Exocytosis of specific granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333294" ], "products": [ "species_10333310" ], "modifiers": [], "additional_components": [ "A0A6I8QDT0", "ENSXETG00000039678", "A0A6I8SHN1", "ENSXETG00000035535", "Q6P8G1", "ENSXETG00000014290", "Q5HZU5", "ENSXETT00000093455", "A0A6I8QPJ5", "ENSXETG00000039590", "A0A6I8RBC3", "ENSXETG00000037351", "A0A6I8QJ14", "ENSXETG00000036342", "A0A6I8RZ58", "ENSXETG00000038864", "Q6DFR0", "ENSXETT00000010030", "A0A6I8SZP6", "ENSXETG00000021325", "F6PTR9", "ENSXETT00000028682", "F7D5C5", "ENSXETT00000001620", "A0A6I8Q0D7", "ENSXETG00000032630", "F6TPK8", "ENSXETT00000008283", "Q5BKE6", "ENSXETT00000089406", "A0A6I8PKK9", "ENSXETG00000033246", "Q28IE5", "ENSXETG00000011864", "A0A6I8R549", "ENSXETG00000011988", "A0A6I8SVI1", "ENSXETG00000012869", "A0A6I8PV16", "ENSXETG00000031089", "A0A6I8REW5", "ENSXETG00000017331", "Q5M7S9", "ENSXETT00000073387", "A0A6I8RCC1", "ENSXETG00000006576", "A0A6I8RID5", "ENSXETG00000037293", "Q501K5", "ENSXETG00000011814", "F7DYP1", "ENSXETT00000013582", "A0A6I8PKK9", "ENSXETG00000033246", "F6TPK8", "ENSXETT00000008283", "Q501K5", "ENSXETG00000011814", "F7DYP1", "ENSXETT00000013582", "A0A6I8RID5", "ENSXETG00000037293", "A0A6I8SVI1", "ENSXETG00000012869", "A0A6I8R549", "ENSXETG00000011988", "A0A6I8QDT0", "ENSXETG00000039678", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8RZ58", "ENSXETG00000038864", "A0A6I8QJ14", "ENSXETG00000036342", "F6PTR9", "ENSXETT00000028682", "Q6DFR0", "ENSXETT00000010030", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8RCC1", "ENSXETG00000006576", "Q5M7S9", "ENSXETT00000073387", "A0A6I8RBC3", "ENSXETG00000037351", "Q5HZU5", "ENSXETT00000093455", "A0A6I8QPJ5", "ENSXETG00000039590", "F7D5C5", "ENSXETT00000001620", "Q5BKE6", "ENSXETT00000089406", "Q6P8G1", "ENSXETG00000014290", "A0A6I8Q0D7", "ENSXETG00000032630", "Q28IE5", "ENSXETG00000011864", "A0A6I8PV16", "ENSXETG00000031089" ] }, "reaction_10333904": { "compartment": "compartment_984", "id": "reaction_10333904", "reactome": "R-XTR-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333882" ], "products": [ "species_10333902" ], "modifiers": [], "additional_components": [ "F6TFI0", "ENSXETT00000050806", "F7B3J1", "ENSXETT00000011348", "A0A6I8QYH5", "ENSXETG00000035070", "L7N3U2", "ENSXETT00000047429", "L7N2L6", "ENSXETT00000005874", "Q28IX9", "ENSXETT00000096095", "A0A6I8SRS9", "ENSXETG00000016932", "Q6P8G1", "ENSXETG00000014290", "A0A6I8SJ17", "ENSXETG00000016072", "Q5BL41", "ENSXETT00000030571", "A0A6I8QJX8", "ENSXETG00000010896", "A0A6I8RSU0", "ENSXETG00000041054", "A0A6I8RU72", "ENSXETG00000041054", "A0A6I8QYQ6", "ENSXETG00000037779", "A0A6I8RMU5", "ENSXETG00000041054", "A0A6I8RCC1", "ENSXETG00000006576", "Q5M7S9", "ENSXETT00000073387", "F6PKQ4", "ENSXETT00000023697", "F6PTR9", "ENSXETT00000028682", "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566", "A0A6I8SKX0", "ENSXETG00000018552", "A0A6I8SR75", "ENSXETG00000037123", "F6T7W4", "ENSXETT00000045926", "Q6GL04", "ENSXETT00000067185", "F6TGE8", "ENSXETT00000000571", "B1H326", "ENSXETT00000060143", "A0A6I8RKW5", "ENSXETG00000019013", "A0A6I8RTF4", "ENSXETG00000038059", "A0A6I8SN57", "ENSXETG00000037611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8RI96", "ENSXETG00000038203", "F7BED4", "ENSXETT00000050679", "A0A6I8PT30", "ENSXETG00000003014", "Q4V9Y5", "ENSXETT00000029363", "A0A6I8QFG6", "ENSXETG00000037805", "A0A6I8SM87", "ENSXETG00000038128", "A0A6I8RUR5", "ENSXETG00000035955", "B5DE93", "ENSXETG00000023695", "A0A6I8R1G6", "ENSXETG00000007490", "A0A6I8QL92", "ENSXETG00000039008", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350", "Q6DEU1", "ENSXETT00000058038", "Q6P326", "ENSXETG00000021646", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8RCL3", "ENSXETG00000006695", "F6PKQ4", "ENSXETT00000023697", "A0A6I8SRS9", "ENSXETG00000016932", "F7B3J1", "ENSXETT00000011348", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "A0A6I8RKW5", "ENSXETG00000019013", "A0A6I8QJX8", "ENSXETG00000010896", "F6T7W4", "ENSXETT00000045926", "L7N2L6", "ENSXETT00000005874", "L7N3U2", "ENSXETT00000047429", "A0A6I8PT30", "ENSXETG00000003014", "A0A6I8RSU0", "ENSXETG00000041054", "A0A6I8RU72", "ENSXETG00000041054", "A0A6I8QYQ6", "ENSXETG00000037779", "A0A6I8RMU5", "ENSXETG00000041054", "A0A6I8RUR5", "ENSXETG00000035955", "A0A6I8SJ17", "ENSXETG00000016072", "A0A6I8RCC1", "ENSXETG00000006576", "Q5M7S9", "ENSXETT00000073387", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8SN57", "ENSXETG00000037611", "A0A6I8RTF4", "ENSXETG00000038059", "Q6P8G1", "ENSXETG00000014290", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8SR75", "ENSXETG00000037123", "A0A6I8SM87", "ENSXETG00000038128", "Q4V9Y5", "ENSXETT00000029363", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350", "A0A6I8QL92", "ENSXETG00000039008", "F7BED4", "ENSXETT00000050679", "B1H326", "ENSXETT00000060143", "F6TFI0", "ENSXETT00000050806", "A0A6I8QFG6", "ENSXETG00000037805", "B5DE93", "ENSXETG00000023695", "Q6DEU1", "ENSXETT00000058038", "Q6P326", "ENSXETG00000021646", "A0A6I8RCL3", "ENSXETG00000006695", "F6PTR9", "ENSXETT00000028682", "A0A6I8R1G6", "ENSXETG00000007490", "Q28IX9", "ENSXETT00000096095", "A0A6I8QYH5", "ENSXETG00000035070", "F6TGE8", "ENSXETT00000000571", "Q6GL04", "ENSXETT00000067185", "Q5BL41", "ENSXETT00000030571", "A0A6I8SKX0", "ENSXETG00000018552" ] }, "reaction_10332768": { "compartment": "compartment_876", "id": "reaction_10332768", "reactome": "R-XTR-6798743", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10332852" ], "products": [ "species_10332896" ], "modifiers": [], "additional_components": [ "Q5BKE6", "ENSXETT00000089406", "A0A6I8SVI1", "ENSXETG00000012869", "A0A6I8Q0D7", "ENSXETG00000032630", "Q501K5", "ENSXETG00000011814", "F7D5C5", "ENSXETT00000001620", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8QDT0", "ENSXETG00000039678", "Q6P8G1", "ENSXETG00000014290", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "Q5M7S9", "ENSXETT00000073387", "A0A6I8RCC1", "ENSXETG00000006576", "F6PKQ4", "ENSXETT00000023697", "A0A6I8PKK9", "ENSXETG00000033246", "F6T7W4", "ENSXETT00000045926", "A0A6I8SN57", "ENSXETG00000037611", "F6PTR9", "ENSXETT00000028682", "A0A6I8RKW5", "ENSXETG00000019013", "Q28IE5", "ENSXETG00000011864", "A0A6I8PT30", "ENSXETG00000003014", "A0A6I8RID5", "ENSXETG00000037293", "A0A6I8PV16", "ENSXETG00000031089", "A0A6I8RUR5", "ENSXETG00000035955", "A0A6I8PKK9", "ENSXETG00000033246", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "F6PKQ4", "ENSXETT00000023697", "Q501K5", "ENSXETG00000011814", "A0A6I8RID5", "ENSXETG00000037293", "A0A6I8SVI1", "ENSXETG00000012869", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "A0A6I8QDT0", "ENSXETG00000039678", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8RKW5", "ENSXETG00000019013", "F6PTR9", "ENSXETT00000028682", "F6T7W4", "ENSXETT00000045926", "A0A6I8PT30", "ENSXETG00000003014", "A0A6I8RUR5", "ENSXETG00000035955", "A0A6I8RCC1", "ENSXETG00000006576", "Q5M7S9", "ENSXETT00000073387", "A0A6I8SN57", "ENSXETG00000037611", "F7D5C5", "ENSXETT00000001620", "Q5BKE6", "ENSXETT00000089406", "Q6P8G1", "ENSXETG00000014290", "A0A6I8Q0D7", "ENSXETG00000032630", "Q28IE5", "ENSXETG00000011864", "A0A6I8PV16", "ENSXETG00000031089" ] }, "reaction_10333042": { "compartment": "compartment_6799713", "id": "reaction_10333042", "reactome": "R-XTR-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333006" ], "products": [ "species_10333040" ], "modifiers": [], "additional_components": [ "F6ZRG8", "ENSXETT00000037913", "A0A6I8PUI6", "ENSXETG00000037491", "A0A6I8PVI0", "ENSXETG00000010850", "A0A1B8Y5B7", "ENSXETT00000104043", "A0A6I8Q475", "ENSXETG00000035544", "A0A6I8SYN8", "ENSXETG00000035544", "A0A6I8Q0D7", "ENSXETG00000032630", "F6TV21", "ENSXETT00000001805", "B0BM39", "ENSXETT00000065869", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8PYT1", "ENSXETG00000036665", "A0A6I8SS44", "ENSXETG00000034408", "Q28H62", "ENSXETT00000054186", "F6WCE6", "ENSXETT00000002749", "B4F6Y3", "ENSXETG00000026765", "A0A6I8SNS8", "ENSXETG00000036363", "A0A6I8SCB5", "ENSXETG00000018128", "Q6DF40", "ENSXETG00000020403", "A0A6I8PZB2", "ENSXETG00000001905", "A0A6I8SB02", "ENSXETG00000038658", "A0A6I8QZM7", "ENSXETG00000032631", "A0A6I8R329", "ENSXETG00000038658", "A0A6I8PPZ5", "ENSXETG00000038658", "A0A6I8QHU4", "ENSXETG00000015523", "A0A6I8SNU5", "ENSXETG00000031444", "A0A6I8PVI0", "ENSXETG00000010850", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8SNU5", "ENSXETG00000031444", "A0A6I8PYT1", "ENSXETG00000036665", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8R329", "ENSXETG00000038658", "A0A6I8PPZ5", "ENSXETG00000038658", "A0A6I8QZM7", "ENSXETG00000032631", "A0A6I8SB02", "ENSXETG00000038658", "B4F6Y3", "ENSXETG00000026765", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "Q28H62", "ENSXETT00000054186", "A0A6I8QHU4", "ENSXETG00000015523", "A0A6I8Q475", "ENSXETG00000035544", "A0A6I8SYN8", "ENSXETG00000035544", "Q6DF40", "ENSXETG00000020403", "A0A6I8SCB5", "ENSXETG00000018128", "A0A6I8SNS8", "ENSXETG00000036363", "A0A6I8PUI6", "ENSXETG00000037491", "A0A6I8PZB2", "ENSXETG00000001905", "A0A1B8Y5B7", "ENSXETT00000104043", "B0BM39", "ENSXETT00000065869", "F6WCE6", "ENSXETT00000002749", "F6TV21", "ENSXETT00000001805", "F6ZRG8", "ENSXETT00000037913", "A0A6I8SS44", "ENSXETG00000034408" ] }, "reaction_10320878": { "compartment": "compartment_876", "id": "reaction_10320878", "reactome": "R-XTR-981713", "name": "C4b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313268", "species_983438" ], "products": [ "species_10313290" ], "modifiers": [], "additional_components": [ "A0A6I8Q4R4", "ENSXETG00000005203", "A0A6I8Q4R4", "ENSXETG00000005203" ] }, "reaction_10313294": { "compartment": "compartment_984", "id": "reaction_10313294", "reactome": "R-XTR-166795", "name": "Formation of Classical C3 convertase (C4b:C2a complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313290", "species_10313274" ], "products": [ "species_10313292" ], "modifiers": [], "additional_components": [ "A0A6I8Q4R4", "ENSXETG00000005203", "ENSXETG00000041348", "A0A6I8R253", "ENSXETG00000041348", "A0A6I8Q4R4", "ENSXETG00000005203" ] }, "reaction_10313469": { "compartment": "compartment_984", "id": "reaction_10313469", "reactome": "R-XTR-173745", "name": "Factor D cleaves C3(H2O)-bound Factor B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313458" ], "products": [ "species_10313462", "species_10313320" ], "modifiers": [ [ "species_10313466", "catalyst" ] ], "additional_components": [ "A0A6I8S693", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "ENSXETG00000039379", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "ENSXETG00000021646" ] }, "reaction_10313981": { "compartment": "compartment_984", "id": "reaction_10313981", "reactome": "R-XTR-183126", "name": "Factor B binds to surface-associated C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313456", "species_10313326" ], "products": [ "species_10313977" ], "modifiers": [], "additional_components": [ "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379" ] }, "reaction_10320876": { "compartment": "compartment_876", "id": "reaction_10320876", "reactome": "R-XTR-981539", "name": "C3b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313307", "species_983438" ], "products": [ "species_10313326" ], "modifiers": [], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992" ] }, "reaction_10313454": { "compartment": "compartment_984", "id": "reaction_10313454", "reactome": "R-XTR-173739", "name": "Spontaneous hydrolysis of C3 thioester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10313303" ], "products": [ "species_10313314" ], "modifiers": [], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992" ] }, "reaction_10313979": { "compartment": "compartment_876", "id": "reaction_10313979", "reactome": "R-XTR-183122", "name": "Factor D cleaves C3b-bound Factor B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313977" ], "products": [ "species_10313462", "species_10313324" ], "modifiers": [ [ "species_10313466", "catalyst" ] ], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "ENSXETG00000021646" ] }, "reaction_10313460": { "compartment": "compartment_984", "id": "reaction_10313460", "reactome": "R-XTR-173740", "name": "Factor B binds to C3(H2O)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313314", "species_10313456" ], "products": [ "species_10313458" ], "modifiers": [], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "ENSXETG00000039379", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992" ] }, "reaction_10313984": { "compartment": "compartment_984", "id": "reaction_10313984", "reactome": "R-XTR-183130", "name": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313303" ], "products": [ "species_10313307", "species_10313309" ], "modifiers": [ [ "species_10313320", "catalyst" ] ], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992" ] }, "reaction_10334989": { "compartment": "compartment_876", "id": "reaction_10334989", "reactome": "R-XTR-8851436", "name": "CFHR dimers bind C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334985", "species_10313326" ], "products": [ "species_10334987" ], "modifiers": [], "additional_components": [ "A0A6I8PQF3", "ENSXETG00000031728", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10321772": { "compartment": "compartment_876", "id": "reaction_10321772", "reactome": "R-XTR-1006169", "name": "Factor H binds host cell surface markers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320787", "species_1006146" ], "products": [ "species_10320851" ], "modifiers": [], "additional_components": [ "ENSXETG00000031728", "species_1604784", "species_1006168", "species_1604784", "species_1006168", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10320856": { "compartment": "compartment_876", "id": "reaction_10320856", "reactome": "R-XTR-977605", "name": "Factor H displaces Bb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320849" ], "products": [ "species_10313318", "species_10320847" ], "modifiers": [], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8PQF3", "ENSXETG00000031728", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10320853": { "compartment": "compartment_876", "id": "reaction_10320853", "reactome": "R-XTR-977363", "name": "Factor H binds to C3bBb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320787", "species_10313324" ], "products": [ "species_10320849" ], "modifiers": [ [ "species_10320851", "catalyst" ] ], "additional_components": [ "ENSXETG00000031728", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8PQF3", "ENSXETG00000031728", "species_1604784", "species_1006168", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10320791": { "compartment": "compartment_984", "id": "reaction_10320791", "reactome": "R-XTR-976768", "name": "Factor H binds to C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320787", "species_10313307" ], "products": [ "species_10320789" ], "modifiers": [], "additional_components": [ "ENSXETG00000031728", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10320880": { "compartment": "compartment_876", "id": "reaction_10320880", "reactome": "R-XTR-981728", "name": "Factor H binds to membrane-associated C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320787", "species_10313326" ], "products": [ "species_10320847" ], "modifiers": [ [ "species_10320851", "catalyst" ] ], "additional_components": [ "ENSXETG00000031728", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8PQF3", "ENSXETG00000031728", "species_1604784", "species_1006168", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10327043": { "compartment": "compartment_984", "id": "reaction_10327043", "reactome": "R-XTR-2855047", "name": "Hydrolysis of internal thioester in C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10313268" ], "products": [ "species_10313281" ], "modifiers": [], "additional_components": [ "A0A6I8Q4R4", "ENSXETG00000005203", "A0A6I8Q4R4", "ENSXETG00000005203" ] }, "reaction_10313452": { "compartment": "compartment_876", "id": "reaction_10313452", "reactome": "R-XTR-173636", "name": "Formation of classic pathway C5 convertase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313326", "species_10313292" ], "products": [ "species_10313328" ], "modifiers": [], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8R253", "ENSXETG00000041348", "A0A6I8Q4R4", "ENSXETG00000005203", "A0A6I8R253", "ENSXETG00000041348", "A0A6I8Q4R4", "ENSXETG00000005203", "A0A6I8Q3I4", "ENSXETG00000032992" ] }, "reaction_10313333": { "compartment": "compartment_984", "id": "reaction_10313333", "reactome": "R-XTR-166817", "name": "Cleavage of C3 by C3 convertases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313303" ], "products": [ "species_10313307", "species_10313309" ], "modifiers": [ [ "species_10313330", "catalyst" ] ], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8R253", "ENSXETG00000041348", "A0A6I8Q4R4", "ENSXETG00000005203" ] }, "reaction_10337951": { "compartment": "compartment_70101", "id": "reaction_10337951", "reactome": "R-XTR-9645394", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312116" ], "products": [ "species_10313391" ], "modifiers": [ [ "species_10337948", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "Q28DL4", "ENSXETG00000007549" ] }, "reaction_10337966": { "compartment": "compartment_70101", "id": "reaction_10337966", "reactome": "R-XTR-9645501", "name": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320680", "species_10337964" ], "products": [ "species_10337953" ], "modifiers": [], "additional_components": [ "ENSXETG00000007549", "Q28DL4", "ENSXETG00000007549", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "Q28DL4", "ENSXETG00000007549", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337976": { "compartment": "compartment_70101", "id": "reaction_10337976", "reactome": "R-XTR-9645524", "name": "ALPK1:ADP-heptose binds TIFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337937", "species_10337972" ], "products": [ "species_10337974" ], "modifiers": [], "additional_components": [ "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "B5DE70", "ENSXETT00000052013", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337979": { "compartment": "compartment_70101", "id": "reaction_10337979", "reactome": "R-XTR-9645535", "name": "ALPK1 phosphorylates TIFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337974", "species_113592" ], "products": [ "species_29370", "species_10337960" ], "modifiers": [ [ "species_10337974", "catalyst" ] ], "additional_components": [ "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337962": { "compartment": "compartment_70101", "id": "reaction_10337962", "reactome": "R-XTR-9645481", "name": "TIFA oligomerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337960" ], "products": [ "species_10337946" ], "modifiers": [], "additional_components": [ "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337956": { "compartment": "compartment_70101", "id": "reaction_10337956", "reactome": "R-XTR-9645414", "name": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337953", "species_10312116" ], "products": [ "species_10337948" ], "modifiers": [ [ "species_10337953", "catalyst" ] ], "additional_components": [ "Q28DL4", "ENSXETG00000007549", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "Q28DL4", "ENSXETG00000007549", "Q28DL4", "ENSXETG00000007549", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337958": { "compartment": "compartment_70101", "id": "reaction_10337958", "reactome": "R-XTR-9645428", "name": "ALPK1 binds ADP-heptose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9645519", "species_10337935" ], "products": [ "species_10337937" ], "modifiers": [], "additional_components": [ "ENSXETG00000024103", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337968": { "compartment": "compartment_70101", "id": "reaction_10337968", "reactome": "R-XTR-9645520", "name": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337946", "species_10320680" ], "products": [ "species_10337964" ], "modifiers": [], "additional_components": [ "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "ENSXETG00000007549", "Q28DL4", "ENSXETG00000007549", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10330607": { "compartment": "compartment_70101", "id": "reaction_10330607", "reactome": "R-XTR-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10324029", "catalyst" ] ], "additional_components": [ "ENSXETG00000016428" ] }, "reaction_10330623": { "compartment": "compartment_5683628", "id": "reaction_10330623", "reactome": "R-XTR-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330602" ], "products": [ "species_10330621" ], "modifiers": [ [ "species_10320527", "catalyst" ] ], "additional_components": [ "species_8959490", "Q5BIZ2", "ENSXETT00000083554", "Q28FC7", "ENSXETT00000085573", "Q5BIZ2", "ENSXETT00000083554", "Q28FC7", "ENSXETT00000085573", "species_8959490", "Q5FW14", "ENSXETG00000016810", "Q5BKM3", "ENSXETT00000038990", "Q6NVL7", "ENSXETT00000016617", "Q6DFS6", "ENSXETT00000041697", "Q6GL11", "ENSXETG00000021424" ] }, "reaction_10336858": { "compartment": "compartment_70101", "id": "reaction_10336858", "reactome": "R-XTR-8948139", "name": "p-S13-FUNDC1 is dephosphorylated by PGAM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336847" ], "products": [ "species_10336844" ], "modifiers": [ [ "species_10336855", "catalyst" ] ], "additional_components": [ "ENSXETG00000004831", "ENSXETG00000004831", "ENSXETG00000023845" ] }, "reaction_10336851": { "compartment": "compartment_17906", "id": "reaction_10336851", "reactome": "R-XTR-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330653" ], "products": [ "species_10336849" ], "modifiers": [], "additional_components": [ "ENSXETG00000002028", "ENSXETG00000002028" ] }, "reaction_10336867": { "compartment": "compartment_17906", "id": "reaction_10336867", "reactome": "R-XTR-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10336844" ], "products": [ "species_10336864", "species_29370" ], "modifiers": [ [ "species_10336849", "catalyst" ] ], "additional_components": [ "ENSXETG00000004831", "ENSXETG00000004831", "ENSXETG00000002028" ] }, "reaction_10330657": { "compartment": "compartment_70101", "id": "reaction_10330657", "reactome": "R-XTR-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330651" ], "products": [ "species_29372", "species_10330655" ], "modifiers": [], "additional_components": [ "A0A6I8QPJ0", "ENSXETG00000002028", "A4IIM9", "ENSXETT00000004248", "A0A6I8QPJ0", "ENSXETG00000002028", "A4IIM9", "ENSXETT00000004248" ] }, "reaction_10337853": { "compartment": "compartment_7660", "id": "reaction_10337853", "reactome": "R-XTR-9629195", "name": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337843", "species_10337849" ], "products": [ "species_10337851" ], "modifiers": [], "additional_components": [ "ENSXETG00000030606", "Q28D37", "ENSXETT00000104494", "A0A6I8RKR7", "ENSXETG00000035354", "B8QB46", "ENSXETG00000012487", "A0A6I8PVF6", "ENSXETG00000031339", "F7E8S9", "ENSXETT00000020406", "Q28D37", "ENSXETT00000104494", "A0A6I8RKR7", "ENSXETG00000035354", "B8QB46", "ENSXETG00000012487", "A0A6I8PVF6", "ENSXETG00000031339", "F7E8S9", "ENSXETT00000020406", "A0A6I8Q015", "ENSXETG00000030606" ] }, "reaction_10337864": { "compartment": "compartment_7660", "id": "reaction_10337864", "reactome": "R-XTR-9629216", "name": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337851" ], "products": [ "species_10337861", "species_9629218" ], "modifiers": [ [ "species_10337851", "catalyst" ] ], "additional_components": [ "Q28D37", "ENSXETT00000104494", "A0A6I8RKR7", "ENSXETG00000035354", "B8QB46", "ENSXETG00000012487", "A0A6I8PVF6", "ENSXETG00000031339", "F7E8S9", "ENSXETT00000020406", "A0A6I8Q015", "ENSXETG00000030606", "A0A6I8Q015", "ENSXETG00000030606", "Q28D37", "ENSXETT00000104494", "A0A6I8RKR7", "ENSXETG00000035354", "B8QB46", "ENSXETG00000012487", "A0A6I8PVF6", "ENSXETG00000031339", "F7E8S9", "ENSXETT00000020406", "Q28D37", "ENSXETT00000104494", "A0A6I8RKR7", "ENSXETG00000035354", "B8QB46", "ENSXETG00000012487", "A0A6I8PVF6", "ENSXETG00000031339", "F7E8S9", "ENSXETT00000020406", "A0A6I8Q015", "ENSXETG00000030606" ] }, "reaction_10312491": { "compartment": "compartment_7660", "id": "reaction_10312491", "reactome": "R-XTR-110246", "name": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312486" ], "products": [ "species_5635947", "species_10312488" ], "modifiers": [ [ "species_10312486", "catalyst" ] ], "additional_components": [ "A0A6I8QBS0", "ENSXETG00000003533", "A0A6I8QBS0", "ENSXETG00000003533", "A0A6I8QBS0", "ENSXETG00000003533" ] }, "reaction_10337882": { "compartment": "compartment_7660", "id": "reaction_10337882", "reactome": "R-XTR-9629492", "name": "NEIL3 cleaves spiroiminodihydantoin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337879" ], "products": [ "species_9629439", "species_10337872" ], "modifiers": [ [ "species_10337879", "catalyst" ] ], "additional_components": [ "A0A6I8Q015", "ENSXETG00000030606", "A0A6I8Q015", "ENSXETG00000030606", "A0A6I8Q015", "ENSXETG00000030606" ] }, "reaction_10337875": { "compartment": "compartment_7660", "id": "reaction_10337875", "reactome": "R-XTR-9629470", "name": "NEIL3 cleaves 5-guanidinohydantoin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337868" ], "products": [ "species_10337872", "species_9629218" ], "modifiers": [ [ "species_10337868", "catalyst" ] ], "additional_components": [ "A0A6I8Q015", "ENSXETG00000030606", "A0A6I8Q015", "ENSXETG00000030606", "A0A6I8Q015", "ENSXETG00000030606" ] }, "reaction_10328441": { "compartment": "compartment_7660", "id": "reaction_10328441", "reactome": "R-XTR-4085350", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10327128" ], "products": [ "species_10328439", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328589": { "compartment": "compartment_7660", "id": "reaction_10328589", "reactome": "R-XTR-4551648", "name": "SUMOylation of TDG with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10312379" ], "products": [ "species_10328587", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000025927", "Q6DEP7", "ENSXETG00000022072", "A0A6I8RWH5", "ENSXETG00000025927", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328620": { "compartment": "compartment_7660", "id": "reaction_10328620", "reactome": "R-XTR-4568848", "name": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328610", "species_10327136" ], "products": [ "species_10328618", "species_10327128" ], "modifiers": [ [ "species_10328508", "catalyst" ] ], "additional_components": [ "ENSXETT00000057859", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "A8WH10", "ENSXETT00000057859", "ENSXETT00000054232", "ENSXETG00000021519" ] }, "reaction_10327230": { "compartment": "compartment_7660", "id": "reaction_10327230", "reactome": "R-XTR-3000433", "name": "SUMOylation of PML with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327222", "species_10327188" ], "products": [ "species_10327227", "species_10327128" ], "modifiers": [ [ "species_10327222", "catalyst" ] ], "additional_components": [ "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000039978", "ENSXETG00000039978", "ENSXETT00000054232", "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328606": { "compartment": "compartment_7660", "id": "reaction_10328606", "reactome": "R-XTR-4551738", "name": "SUMOylation of TDG with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328443", "species_10312379" ], "products": [ "species_10327128", "species_10328604" ], "modifiers": [ [ "species_10328443", "catalyst" ] ], "additional_components": [ "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462", "ENSXETG00000025927", "ENSXETT00000054232", "ENSXETG00000025927", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462" ] }, "reaction_10328632": { "compartment": "compartment_7660", "id": "reaction_10328632", "reactome": "R-XTR-4568863", "name": "SUMOylation of RAD52 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10312157" ], "products": [ "species_10328630", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000009413", "Q6DEP7", "ENSXETG00000022072", "A0A6I8RDE5", "ENSXETG00000009413", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328682": { "compartment": "compartment_7660", "id": "reaction_10328682", "reactome": "R-XTR-4570553", "name": "SUMOylation of MDC1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328677", "species_10328443" ], "products": [ "species_10327128", "species_10328680" ], "modifiers": [ [ "species_10328443", "catalyst" ] ], "additional_components": [ "ENSXETG00000039209", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462", "ENSXETT00000054232", "ENSXETG00000039209", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462" ] }, "reaction_10328644": { "compartment": "compartment_7660", "id": "reaction_10328644", "reactome": "R-XTR-4568914", "name": "SUMOylation of BLM with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328443", "species_10328636" ], "products": [ "species_10328642", "species_10327128" ], "modifiers": [ [ "species_10328443", "catalyst" ] ], "additional_components": [ "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462", "ENSXETG00000007847", "ENSXETG00000007847", "ENSXETT00000054232", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462" ] }, "reaction_10328692": { "compartment": "compartment_7660", "id": "reaction_10328692", "reactome": "R-XTR-4570554", "name": "SUMOylation of MDC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328677" ], "products": [ "species_10328690", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000039209", "Q6DEP7", "ENSXETG00000022072", "A0A6I8SUQ0", "ENSXETG00000039209", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10327201": { "compartment": "compartment_7660", "id": "reaction_10327201", "reactome": "R-XTR-3000383", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10327188" ], "products": [ "species_10327128", "species_10327198" ], "modifiers": [ [ "species_10327128", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000039978", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "A0A6I8SBS8", "ENSXETG00000039978", "ENSXETT00000054232" ] }, "reaction_10328673": { "compartment": "compartment_7660", "id": "reaction_10328673", "reactome": "R-XTR-4570528", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328663" ], "products": [ "species_10327128", "species_10328671" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000033244", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "A0A6I8PUF7", "ENSXETG00000033244", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328579": { "compartment": "compartment_7660", "id": "reaction_10328579", "reactome": "R-XTR-4551616", "name": "SUMOylation of RPA1 (RPA70) with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328443", "species_10311307" ], "products": [ "species_10328576", "species_10327128" ], "modifiers": [ [ "species_10328443", "catalyst" ] ], "additional_components": [ "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462", "ENSXETG00000013538", "ENSXETG00000013538", "ENSXETT00000054232", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462" ] }, "reaction_10328649": { "compartment": "compartment_7660", "id": "reaction_10328649", "reactome": "R-XTR-4570485", "name": "SUMOylation of Histone H4 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313794", "species_10327222" ], "products": [ "species_10328647", "species_10327128" ], "modifiers": [ [ "species_10327222", "catalyst" ] ], "additional_components": [ "ENSXETG00000035354", "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000035354", "ENSXETT00000054232", "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328739": { "compartment": "compartment_7660", "id": "reaction_10328739", "reactome": "R-XTR-4616015", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328729" ], "products": [ "species_10328737", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETT00000023583", "Q6DEP7", "ENSXETG00000022072", "F6QFY1", "ENSXETT00000023583", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328659": { "compartment": "compartment_7660", "id": "reaction_10328659", "reactome": "R-XTR-4570496", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313794", "species_10327136" ], "products": [ "species_10328657", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "ENSXETG00000035354", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "A0A6I8RKR7", "ENSXETG00000035354", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328722": { "compartment": "compartment_7660", "id": "reaction_10328722", "reactome": "R-XTR-4615889", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10321877" ], "products": [ "species_10328720", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000005253", "A0A6I8SGY5", "ENSXETG00000005253", "Q6DEP7", "ENSXETG00000022072", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328845": { "compartment": "compartment_7660", "id": "reaction_10328845", "reactome": "R-XTR-4719436", "name": "PIAS2,3,4 SUMOylate RORA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10317102" ], "products": [ "species_10328843", "species_10327128" ], "modifiers": [ [ "species_10328832", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000021123", "Q6DEP7", "ENSXETG00000022072", "A0A6I8QBV8", "ENSXETG00000021123", "ENSXETT00000054232", "A0A6I8Q277", "ENSXETG00000021519", "A0A6I8S7F8", "ENSXETG00000018642" ] }, "reaction_10328572": { "compartment": "compartment_7660", "id": "reaction_10328572", "reactome": "R-XTR-4546386", "name": "PIAS1,3 SUMOylates NR5A1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10317110" ], "products": [ "species_10328570", "species_10327128" ], "modifiers": [ [ "species_10328492", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETT00000025024", "F7EHW3", "ENSXETT00000025024", "Q6DEP7", "ENSXETG00000022072", "ENSXETT00000054232", "ENSXETG00000018642" ] }, "reaction_10328511": { "compartment": "compartment_7660", "id": "reaction_10328511", "reactome": "R-XTR-4090390", "name": "PIAS1,2-1 SUMOylates AR with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10317088" ], "products": [ "species_10327128", "species_10328504" ], "modifiers": [ [ "species_10328508", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000005089", "ENSXETT00000054232", "A0A6I8RK73", "ENSXETG00000005089", "Q6DEP7", "ENSXETG00000022072", "ENSXETG00000021519" ] }, "reaction_10328942": { "compartment": "compartment_7660", "id": "reaction_10328942", "reactome": "R-XTR-4755494", "name": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328932" ], "products": [ "species_10327128", "species_10328940" ], "modifiers": [ [ "species_10328508", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "CHEBI:77361", "F7EHW3", "ENSXETT00000025024", "ENSXETT00000054232", "CHEBI:77361", "F7EHW3", "ENSXETT00000025024", "Q6DEP7", "ENSXETG00000022072", "ENSXETG00000021519" ] }, "reaction_10328536": { "compartment": "compartment_7660", "id": "reaction_10328536", "reactome": "R-XTR-4341025", "name": "SUMOylation of NR3C1 (GR) with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328523" ], "products": [ "species_10328534", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "A0A6I8S149", "ENSXETG00000040373", "Q6DEP7", "ENSXETG00000022072", "A0A6I8S149", "ENSXETG00000040373", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328548": { "compartment": "compartment_7660", "id": "reaction_10328548", "reactome": "R-XTR-4341073", "name": "PIAS3 SUMOylates PGR with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317074", "species_10327136" ], "products": [ "species_10328546", "species_10327128" ], "modifiers": [ [ "species_10328492", "catalyst" ] ], "additional_components": [ "ENSXETT00000040897", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "F6SI83", "ENSXETT00000040897", "ENSXETT00000054232", "ENSXETG00000018642" ] }, "reaction_10328951": { "compartment": "compartment_7660", "id": "reaction_10328951", "reactome": "R-XTR-4755524", "name": "SUMOylation of NR1I2 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328944", "species_10327222" ], "products": [ "species_10328949", "species_10327128" ], "modifiers": [], "additional_components": [ "A0A6I8RH34", "ENSXETG00000031759", "CHEBI:28077", "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232", "CHEBI:28077", "A0A6I8RH34", "ENSXETG00000031759", "ENSXETT00000054232" ] }, "reaction_10328561": { "compartment": "compartment_7660", "id": "reaction_10328561", "reactome": "R-XTR-4546385", "name": "PIAS1,3 SUMOylates NR5A1 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317110", "species_10327209" ], "products": [ "species_10327128", "species_10328559" ], "modifiers": [ [ "species_10328492", "catalyst" ] ], "additional_components": [ "ENSXETT00000025024", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "ENSXETT00000054232", "ENSXETT00000025024", "ENSXETG00000018642" ] }, "reaction_10328835": { "compartment": "compartment_7660", "id": "reaction_10328835", "reactome": "R-XTR-4719413", "name": "PIAS2,3,4 SUMOylate RORA with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327209", "species_10317102" ], "products": [ "species_10327128", "species_10328830" ], "modifiers": [ [ "species_10328832", "catalyst" ] ], "additional_components": [ "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "ENSXETG00000021123", "ENSXETT00000054232", "ENSXETG00000021123", "A0A6I8Q277", "ENSXETG00000021519", "A0A6I8S7F8", "ENSXETG00000018642" ] }, "reaction_10328495": { "compartment": "compartment_7660", "id": "reaction_10328495", "reactome": "R-XTR-4090288", "name": "PIAS1,3 SUMOylate MBD1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328479" ], "products": [ "species_10327128", "species_10328488" ], "modifiers": [ [ "species_10328492", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000040845", "ENSXETT00000054232", "A0A6I8RGR4", "ENSXETG00000040845", "Q6DEP7", "ENSXETG00000022072", "ENSXETG00000018642" ] }, "reaction_10328219": { "compartment": "compartment_7660", "id": "reaction_10328219", "reactome": "R-XTR-3782535", "name": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328201" ], "products": [ "species_10327128", "species_10328216" ], "modifiers": [ [ "species_10320733", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "A0A6I8QJW7", "ENSXETG00000019245", "A0A6I8RRG3", "ENSXETG00000040574", "A0A6I8RGG7", "ENSXETG00000035980", "ENSXETT00000054232", "A0A6I8RRG3", "ENSXETG00000040574", "A0A6I8RGG7", "ENSXETG00000035980", "Q6DEP7", "ENSXETG00000022072", "A0A6I8QJW7", "ENSXETG00000019245", "ENSXETG00000019245" ] }, "reaction_10328336": { "compartment": "compartment_7660", "id": "reaction_10328336", "reactome": "R-XTR-3900177", "name": "SUMOylation of DDX5 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328325" ], "products": [ "species_10327128", "species_10328333" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETT00000044525", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "F7CZ58", "ENSXETT00000044525", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10337527": { "compartment": "compartment_7660", "id": "reaction_10337527", "reactome": "R-XTR-9023860", "name": "Histone acetyltransferases are recruited to the TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337523", "species_10337509" ], "products": [ "species_10337525" ], "modifiers": [], "additional_components": [ "Q6DEQ4", "ENSXETT00000056546", "Q28GG8", "ENSXETT00000018725", "L7N2Q7", "ENSXETT00000009600", "Q8AWH1", "ENSXETG00000025867", "CHEBI:142773", "species_193066", "species_193132", "CHEBI:27974", "F7CZ58", "ENSXETT00000044525", "Q28F07", "ENSXETT00000094658", "ENSXETG00000041035", "A0A6I8SAY5", "ENSXETG00000041035", "Q6DEQ4", "ENSXETT00000056546", "Q28GG8", "ENSXETT00000018725", "L7N2Q7", "ENSXETT00000009600", "Q8AWH1", "ENSXETG00000025867", "CHEBI:142773", "species_193066", "species_193132", "CHEBI:27974", "F7CZ58", "ENSXETT00000044525", "Q28F07", "ENSXETT00000094658" ] }, "reaction_10317879": { "compartment": "compartment_984", "id": "reaction_10317879", "reactome": "R-XTR-420489", "name": "Parathyroid hormone receptor can bind parathyroid hormone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317875", "species_10317871" ], "products": [ "species_10317877" ], "modifiers": [], "additional_components": [ "ENSXETG00000037389", "Q5G7I8", "ENSXETT00000000004", "F6UDH6", "ENSXETT00000022720", "Q5G7I8", "ENSXETT00000000004", "F6UDH6", "ENSXETT00000022720", "A0A6I8QXF2", "ENSXETG00000037389" ] }, "reaction_10318448": { "compartment": "compartment_984", "id": "reaction_10318448", "reactome": "R-XTR-444773", "name": "EGF-TM7 receptors bind chondroitin sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444761", "species_10318444" ], "products": [ "species_10318446" ], "modifiers": [], "additional_components": [ "F6WSE4", "ENSXETT00000003359", "F6WSE4", "ENSXETT00000003359", "species_444761" ] }, "reaction_10317843": { "compartment": "compartment_984", "id": "reaction_10317843", "reactome": "R-XTR-420214", "name": "The adrenomedullin receptor can bind adrenomedullin and intermedin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317829", "species_10317839" ], "products": [ "species_10317841" ], "modifiers": [], "additional_components": [ "A0A6I8SCW9", "ENSXETG00000040245", "A0A6I8REF2", "ENSXETG00000034576", "A0A6I8QAL9", "ENSXETG00000035598", "Q0P4Y4", "ENSXETT00000074242", "A0A6I8QAL9", "ENSXETG00000035598", "Q0P4Y4", "ENSXETT00000074242", "A0A6I8SCW9", "ENSXETG00000040245", "A0A6I8REF2", "ENSXETG00000034576" ] }, "reaction_10317901": { "compartment": "compartment_984", "id": "reaction_10317901", "reactome": "R-XTR-420739", "name": "GPRC6A can bind L-alpha amino acids and calcium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_420706", "species_10317897" ], "products": [ "species_10317899" ], "modifiers": [], "additional_components": [ "species_74112", "CHEBI:32551", "species_29468", "species_29498", "ENSXETG00000032935", "A0A6I8PQL7", "ENSXETG00000032935", "species_74112", "CHEBI:32551", "species_29468", "species_29498" ] }, "reaction_10327557": { "compartment": "compartment_876", "id": "reaction_10327557", "reactome": "R-XTR-3296233", "name": "T2Rs bind bitter-tasting compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320034", "species_3296423" ], "products": [ "species_10320036" ], "modifiers": [], "additional_components": [ "Q2AB79", "ENSXETT00000093107", "Q2AB72", "ENSXETT00000061687", "Q2AB77", "ENSXETT00000063907", "Q2AB63", "ENSXETT00000061269", "Q2AB68", "ENSXETT00000060826", "Q2AB52", "ENSXETT00000063621", "Q2AB53", "ENSXETT00000018688", "Q2AB48", "ENSXETT00000065249", "Q2AB51", "ENSXETT00000063088", "Q2AB44", "ENSXETT00000066089", "Q2AB45", "ENSXETT00000079130", "Q2AB41", "ENSXETT00000061480", "Q2AB42", "ENSXETT00000065552", "Q2AB38", "ENSXETT00000033481", "Q2AB39", "ENSXETT00000082983", "Q2AB34", "ENSXETT00000060343", "Q2AB35", "ENSXETT00000062616", "A0A6I8RXG4", "ENSXETG00000036502", "A0A6I8S8Y1", "ENSXETG00000038186", "A0A6I8Q8V5", "ENSXETG00000035342", "A0A6I8R2L9", "ENSXETG00000036502", "A0A6I8PTF7", "ENSXETG00000036502", "A0A6I8Q288", "ENSXETG00000031892", "A0A6I8PS37", "ENSXETG00000032405", "A0A6I8PSM4", "ENSXETG00000008531", "A0A6I8PK15", "ENSXETG00000027471", "A0A6I8PQY6", "ENSXETG00000040729", "A0A6I8PJF9", "ENSXETG00000040152", "CHEBI:3193", "species_76328", "CHEBI:3768", "CHEBI:10093", "CHEBI:17814", "species_40727", "CHEBI:8206", "CHEBI:48923", "CHEBI:28973", "CHEBI:73228", "CHEBI:23359", "CHEBI:28241", "CHEBI:73226", "CHEBI:73224", "CHEBI:65408", "CHEBI:3944", "CHEBI:73235", "CHEBI:73231", "CHEBI:16226", "CHEBI:27613", "CHEBI:5547", "CHEBI:2825", "CHEBI:73232", "CHEBI:18305", "CHEBI:3445", "CHEBI:36773", "CHEBI:2622", "CHEBI:73237", "CHEBI:2366", "CHEBI:3941", "CHEBI:7939", "CHEBI:351346", "CHEBI:8692", "CHEBI:73239", "CHEBI:15854", "CHEBI:9162", "CHEBI:26948", "CHEBI:50042", "CHEBI:69236", "CHEBI:73222", "CHEBI:17698", "CHEBI:73236", "CHEBI:2853", "CHEBI:3193", "species_76328", "CHEBI:3768", "CHEBI:10093", "CHEBI:17814", "species_40727", "CHEBI:8206", "CHEBI:48923", "CHEBI:28973", "CHEBI:73228", "CHEBI:23359", "CHEBI:28241", "CHEBI:73226", "CHEBI:73224", "CHEBI:65408", "CHEBI:3944", "CHEBI:73235", "CHEBI:73231", "CHEBI:16226", "CHEBI:27613", "CHEBI:5547", "CHEBI:2825", "CHEBI:73232", "CHEBI:18305", "CHEBI:3445", "CHEBI:36773", "CHEBI:2622", "CHEBI:73237", "CHEBI:2366", "CHEBI:3941", "CHEBI:7939", "CHEBI:351346", "CHEBI:8692", "CHEBI:73239", "CHEBI:15854", "CHEBI:9162", "CHEBI:26948", "CHEBI:50042", "CHEBI:69236", "CHEBI:73222", "CHEBI:17698", "CHEBI:73236", "CHEBI:2853", "Q2AB79", "ENSXETT00000093107", "Q2AB72", "ENSXETT00000061687", "Q2AB77", "ENSXETT00000063907", "Q2AB63", "ENSXETT00000061269", "Q2AB68", "ENSXETT00000060826", "Q2AB52", "ENSXETT00000063621", "Q2AB53", "ENSXETT00000018688", "Q2AB48", "ENSXETT00000065249", "Q2AB51", "ENSXETT00000063088", "Q2AB44", "ENSXETT00000066089", "Q2AB45", "ENSXETT00000079130", "Q2AB41", "ENSXETT00000061480", "Q2AB42", "ENSXETT00000065552", "Q2AB38", "ENSXETT00000033481", "Q2AB39", "ENSXETT00000082983", "Q2AB34", "ENSXETT00000060343", "Q2AB35", "ENSXETT00000062616", "A0A6I8RXG4", "ENSXETG00000036502", "A0A6I8S8Y1", "ENSXETG00000038186", "A0A6I8Q8V5", "ENSXETG00000035342", "A0A6I8R2L9", "ENSXETG00000036502", "A0A6I8PTF7", "ENSXETG00000036502", "A0A6I8Q288", "ENSXETG00000031892", "A0A6I8PS37", "ENSXETG00000032405", "A0A6I8PSM4", "ENSXETG00000008531", "A0A6I8PK15", "ENSXETG00000027471", "A0A6I8PQY6", "ENSXETG00000040729", "A0A6I8PJF9", "ENSXETG00000040152" ] }, "reaction_10316852": { "compartment": "compartment_984", "id": "reaction_10316852", "reactome": "R-XTR-373075", "name": "Metabotropic glutamate receptors bind glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316848", "species_210382" ], "products": [ "species_10316850" ], "modifiers": [], "additional_components": [ "ENSXETG00000006732", "species_210382", "A0A6I8RDQ8", "ENSXETG00000006732" ] }, "reaction_10317446": { "compartment": "compartment_984", "id": "reaction_10317446", "reactome": "R-XTR-390835", "name": "DRD1,5 bind DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317442", "species_380873" ], "products": [ "species_10317444" ], "modifiers": [], "additional_components": [ "ENSXETG00000026496", "species_351601", "A0A6I8PSM8", "ENSXETG00000026496" ] }, "reaction_10317454": { "compartment": "compartment_984", "id": "reaction_10317454", "reactome": "R-XTR-390909", "name": "HRH2 binds hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317450", "species_390899" ], "products": [ "species_10317452" ], "modifiers": [], "additional_components": [ "ENSXETG00000029997", "species_390899", "A0A6I8Q5E3", "ENSXETG00000029997" ] }, "reaction_10317462": { "compartment": "compartment_984", "id": "reaction_10317462", "reactome": "R-XTR-390912", "name": "HRH1 binds hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317458", "species_390899" ], "products": [ "species_10317460" ], "modifiers": [], "additional_components": [ "ENSXETG00000007717", "species_390899", "A0A6I8QYI9", "ENSXETG00000007717" ] }, "reaction_10317438": { "compartment": "compartment_984", "id": "reaction_10317438", "reactome": "R-XTR-390649", "name": "CHRM1,3,5 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317434", "species_372533" ], "products": [ "species_10317436" ], "modifiers": [], "additional_components": [ "A0A6I8PJ30", "ENSXETG00000017868", "A0A6I8SRX2", "ENSXETG00000037602", "species_372533", "A0A6I8PJ30", "ENSXETG00000017868", "A0A6I8SRX2", "ENSXETG00000037602" ] }, "reaction_10337759": { "compartment": "compartment_984", "id": "reaction_10337759", "reactome": "R-XTR-9611839", "name": "3-agonists bind ADRB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9611836", "species_10319102" ], "products": [ "species_10337757" ], "modifiers": [], "additional_components": [ "ENSXETG00000030790", "A0A6I8PZ77", "ENSXETG00000030790" ] }, "reaction_10317422": { "compartment": "compartment_984", "id": "reaction_10317422", "reactome": "R-XTR-390641", "name": "ADRA1A,B,D bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317414", "species_390627" ], "products": [ "species_10317416" ], "modifiers": [ [ "species_10317420", "catalyst" ], [ "species_10317418", "inhibitor" ] ], "additional_components": [ "F6SBD0", "ENSXETT00000037826", "A0A6I8RMZ6", "ENSXETG00000035197", "CHEBI:28918", "CHEBI:18357", "CHEBI:28918", "CHEBI:18357", "F6SBD0", "ENSXETT00000037826", "A0A6I8RMZ6", "ENSXETG00000035197", "F6SBD0", "ENSXETT00000037826", "A0A6I8RMZ6", "ENSXETG00000035197", "F6SBD0", "ENSXETT00000037826", "A0A6I8RMZ6", "ENSXETG00000035197" ] }, "reaction_10337755": { "compartment": "compartment_984", "id": "reaction_10337755", "reactome": "R-XTR-9609310", "name": "-blockers bind ADRB1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9609307", "species_10319102" ], "products": [ "species_10337753" ], "modifiers": [], "additional_components": [ "ENSXETG00000030790", "A0A6I8PZ77", "ENSXETG00000030790" ] }, "reaction_10337761": { "compartment": "compartment_984", "id": "reaction_10337761", "reactome": "R-XTR-9611852", "name": "ADRB3 bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10319102" ], "products": [ "species_10319104" ], "modifiers": [ [ "species_10337757", "catalyst" ], [ "species_10337753", "inhibitor" ] ], "additional_components": [ "CHEBI:28918", "CHEBI:18357", "ENSXETG00000030790", "A0A6I8PZ77", "ENSXETG00000030790", "CHEBI:28918", "CHEBI:18357", "A0A6I8PZ77", "ENSXETG00000030790", "A0A6I8PZ77", "ENSXETG00000030790" ] }, "reaction_10317574": { "compartment": "compartment_984", "id": "reaction_10317574", "reactome": "R-XTR-391211", "name": "Trace amine-associated receptors can bind trace amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317570", "species_391200" ], "products": [ "species_10317572" ], "modifiers": [], "additional_components": [ "A0A6I8RAX0", "ENSXETG00000039183", "species_391200", "A0A6I8RAX0", "ENSXETG00000039183" ] }, "reaction_10317480": { "compartment": "compartment_984", "id": "reaction_10317480", "reactome": "R-XTR-390929", "name": "HTR1 and 5A receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10317476" ], "products": [ "species_10317478" ], "modifiers": [], "additional_components": [ "A0A6I8R5Z0", "ENSXETG00000038202", "A0A6I8QW91", "ENSXETG00000040924", "A0A6I8QWR5", "ENSXETG00000036447", "A0A6I8R5Z0", "ENSXETG00000038202", "A0A6I8QW91", "ENSXETG00000040924", "A0A6I8QWR5", "ENSXETG00000036447", "species_114523" ] }, "reaction_10317496": { "compartment": "compartment_984", "id": "reaction_10317496", "reactome": "R-XTR-390931", "name": "5-HT4, 6 and 7 receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10317492" ], "products": [ "species_10317494" ], "modifiers": [], "additional_components": [ "ENSXETG00000031961", "A0A6I8PXU4", "ENSXETG00000031961", "species_114523" ] }, "reaction_10338203": { "compartment": "compartment_984", "id": "reaction_10338203", "reactome": "R-XTR-9693347", "name": "HTR1A binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338199", "species_114523" ], "products": [ "species_10338201" ], "modifiers": [], "additional_components": [ "ENSXETT00000025697", "species_114523", "F7CKP0", "ENSXETT00000025697" ] }, "reaction_10317488": { "compartment": "compartment_984", "id": "reaction_10317488", "reactome": "R-XTR-390930", "name": "5-HT2 receptor can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10317484" ], "products": [ "species_10317486" ], "modifiers": [], "additional_components": [ "ENSXETT00000009523", "F7D3H9", "ENSXETT00000009523", "species_114523" ] }, "reaction_10334962": { "compartment": "compartment_876", "id": "reaction_10334962", "reactome": "R-XTR-8851298", "name": "GPR143 binds L-Dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10319146", "species_8851314" ], "products": [ "species_10319148" ], "modifiers": [], "additional_components": [ "ENSXETT00000044971", "species_8851314", "F6TV02", "ENSXETT00000044971" ] }, "reaction_10334041": { "compartment": "compartment_984", "id": "reaction_10334041", "reactome": "R-XTR-6805205", "name": "GPR35 binds kynurenic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334037", "species_6805204" ], "products": [ "species_10334039" ], "modifiers": [], "additional_components": [ "ENSXETG00000032766", "species_6805204", "A0A6I8PMC3", "ENSXETG00000032766" ] }, "reaction_10318999": { "compartment": "compartment_984", "id": "reaction_10318999", "reactome": "R-XTR-517536", "name": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318995", "species_517533" ], "products": [ "species_10318997" ], "modifiers": [], "additional_components": [ "ENSXETG00000032224", "species_517533", "A0A6I8Q5A1", "ENSXETG00000032224" ] }, "reaction_10318398": { "compartment": "compartment_984", "id": "reaction_10318398", "reactome": "R-XTR-444527", "name": "FPR is a receptor for formyl peptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318394", "species_444519" ], "products": [ "species_10318396" ], "modifiers": [], "additional_components": [ "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8Q632", "ENSXETG00000041332", "species_444519", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8Q632", "ENSXETG00000041332" ] }, "reaction_10318384": { "compartment": "compartment_984", "id": "reaction_10318384", "reactome": "R-XTR-444476", "name": "FPRL2 receptor binds a wide range of ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318376", "species_10318380" ], "products": [ "species_10318382" ], "modifiers": [], "additional_components": [ "A0A6I8Q632", "ENSXETG00000041332", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8SM80", "ENSXETG00000041332", "ENSXETT00000057031", "Q6DJ66", "ENSXETT00000057031", "A0A6I8Q632", "ENSXETG00000041332", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8SM80", "ENSXETG00000041332" ] }, "reaction_10317308": { "compartment": "compartment_984", "id": "reaction_10317308", "reactome": "R-XTR-388560", "name": "Endothelin receptors bind endothelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317300", "species_10317304" ], "products": [ "species_10317306" ], "modifiers": [], "additional_components": [ "ENSXETG00000041205", "ENSXETT00000033726", "F6RQM0", "ENSXETT00000033726", "A0A6I8QC71", "ENSXETG00000041205" ] }, "reaction_10316908": { "compartment": "compartment_984", "id": "reaction_10316908", "reactome": "R-XTR-373791", "name": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316886", "species_10316904" ], "products": [ "species_10316906" ], "modifiers": [], "additional_components": [ "F6XNR7", "ENSXETT00000034054", "A0A6I8T2T2", "ENSXETG00000036062", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8QDT0", "ENSXETG00000039678", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8QDT0", "ENSXETG00000039678", "F6XNR7", "ENSXETT00000034054", "A0A6I8T2T2", "ENSXETG00000036062" ] }, "reaction_10318316": { "compartment": "compartment_984", "id": "reaction_10318316", "reactome": "R-XTR-443986", "name": "Receptor ACKR2 binds most inflammatory CC chemokines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318292", "species_10318312" ], "products": [ "species_10318314" ], "modifiers": [], "additional_components": [ "ENSXETT00000003445", "A0A6I8SVN2", "ENSXETG00000037100", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "F7C531", "ENSXETT00000003445" ] }, "reaction_10316975": { "compartment": "compartment_984", "id": "reaction_10316975", "reactome": "R-XTR-374214", "name": "Receptors CXCR4 and 7 bind CXCL12 ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316967", "species_10316971" ], "products": [ "species_10316973" ], "modifiers": [], "additional_components": [ "ENSXETT00000032559", "ENSXETT00000068483", "Q5EBF6", "ENSXETT00000068483", "Q07FZ4", "ENSXETT00000032559" ] }, "reaction_10316942": { "compartment": "compartment_984", "id": "reaction_10316942", "reactome": "R-XTR-373813", "name": "Receptor CXCR2 binds ligands CXCL1 to 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316938", "species_10316910" ], "products": [ "species_10316940" ], "modifiers": [], "additional_components": [ "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8QDT0", "ENSXETG00000039678", "ENSXETG00000036062", "A0A6I8T2T2", "ENSXETG00000036062", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8QDT0", "ENSXETG00000039678" ] }, "reaction_10316872": { "compartment": "compartment_876", "id": "reaction_10316872", "reactome": "R-XTR-373342", "name": "CX3CR1 binds CX3CL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316818", "species_10316868" ], "products": [ "species_10316870" ], "modifiers": [], "additional_components": [ "A0A6I8R4J8", "ENSXETG00000041335", "F6RFH7", "ENSXETT00000046189", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8R4J8", "ENSXETG00000041335", "F6RFH7", "ENSXETT00000046189" ] }, "reaction_10335627": { "compartment": "compartment_984", "id": "reaction_10335627", "reactome": "R-XTR-8862733", "name": "CCR2, CCR3 bind CCL13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320058", "species_10320060" ], "products": [ "species_10320062" ], "modifiers": [], "additional_components": [ "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "F6RFH7", "ENSXETT00000046189", "A0A6I8R4J8", "ENSXETG00000041335", "F6RFH7", "ENSXETT00000046189", "A0A6I8R4J8", "ENSXETG00000041335", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100" ] }, "reaction_10316836": { "compartment": "compartment_984", "id": "reaction_10316836", "reactome": "R-XTR-373061", "name": "Receptors CCR3, 4 and 5 bind CCL5 ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316832", "species_10316808" ], "products": [ "species_10316834" ], "modifiers": [], "additional_components": [ "F6RFH7", "ENSXETT00000046189", "A0A6I8R4J8", "ENSXETG00000041335", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "F6RFH7", "ENSXETT00000046189", "A0A6I8R4J8", "ENSXETG00000041335" ] }, "reaction_10334964": { "compartment": "compartment_876", "id": "reaction_10334964", "reactome": "R-XTR-8851352", "name": "CCR8 binds CCL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320070", "species_10316812" ], "products": [ "species_10320072" ], "modifiers": [], "additional_components": [ "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "ENSXETG00000041335", "A0A6I8R4J8", "ENSXETG00000041335", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100" ] }, "reaction_10317326": { "compartment": "compartment_984", "id": "reaction_10317326", "reactome": "R-XTR-388900", "name": "Neurotensin receptors can bind neurotensins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317316", "species_10317320" ], "products": [ "species_10317324" ], "modifiers": [], "additional_components": [ "ENSXETG00000040562", "ENSXETG00000037844", "A0A6I8S4R6", "ENSXETG00000037844", "A0A6I8QBR7", "ENSXETG00000040562" ] }, "reaction_10317048": { "compartment": "compartment_984", "id": "reaction_10317048", "reactome": "R-XTR-375384", "name": "Bombesin-like receptors bind bombesin homologues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317040", "species_10317044" ], "products": [ "species_10317046" ], "modifiers": [], "additional_components": [ "ENSXETT00000045737", "ENSXETG00000030584", "A0A6I8Q016", "ENSXETG00000030584", "F7CE29", "ENSXETT00000045737" ] }, "reaction_10337771": { "compartment": "compartment_984", "id": "reaction_10337771", "reactome": "R-XTR-9615249", "name": "ARBs bind AGRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316946", "species_9615246" ], "products": [ "species_10316960" ], "modifiers": [], "additional_components": [ "ENSXETT00000023026", "B3DLC0", "ENSXETT00000023026" ] }, "reaction_10318464": { "compartment": "compartment_984", "id": "reaction_10318464", "reactome": "R-XTR-444848", "name": "Relaxin 3 receptor 1 binds relaxin 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318452", "species_10318460" ], "products": [ "species_10318462" ], "modifiers": [], "additional_components": [ "ENSXETT00000037509", "B1AAQ2", "ENSXETT00000062741", "B1AAQ2", "ENSXETT00000062741", "F7E376", "ENSXETT00000037509" ] }, "reaction_10318480": { "compartment": "compartment_984", "id": "reaction_10318480", "reactome": "R-XTR-444859", "name": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318466", "species_10318476" ], "products": [ "species_10318478" ], "modifiers": [], "additional_components": [ "ENSXETT00000037509", "B1AAQ2", "ENSXETT00000062741", "A0A6I8SQK1", "ENSXETG00000036496", "B1AAQ2", "ENSXETT00000062741", "A0A6I8SQK1", "ENSXETG00000036496", "F7E376", "ENSXETT00000037509" ] }, "reaction_10317344": { "compartment": "compartment_984", "id": "reaction_10317344", "reactome": "R-XTR-389487", "name": "Orexin 2 receptor can bind orexin-B neuropeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317336", "species_10317340" ], "products": [ "species_10317342" ], "modifiers": [], "additional_components": [ "ENSXETG00000036925", "ENSXETT00000034321", "F6UHP0", "ENSXETT00000034321", "A0A6I8RRB4", "ENSXETG00000036925" ] }, "reaction_10316962": { "compartment": "compartment_984", "id": "reaction_10316962", "reactome": "R-XTR-374173", "name": "AGT(34-41) binds to AGTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316946", "species_10316956" ], "products": [ "species_10316958" ], "modifiers": [ [ "species_10316960", "inhibitor" ] ], "additional_components": [ "ENSXETT00000023026", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "B3DLC0", "ENSXETT00000023026", "B3DLC0", "ENSXETT00000023026" ] }, "reaction_10320722": { "compartment": "compartment_876", "id": "reaction_10320722", "reactome": "R-XTR-947673", "name": "Melanin-concentrating hormone receptors bind MCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10319136", "species_10319140" ], "products": [ "species_10319142" ], "modifiers": [], "additional_components": [ "ENSXETT00000065305", "ENSXETG00000030934", "A0A6I8PX40", "ENSXETG00000030934", "F6YI59", "ENSXETT00000065305" ] }, "reaction_10317817": { "compartment": "compartment_984", "id": "reaction_10317817", "reactome": "R-XTR-419428", "name": "S1PR2-5 bind S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_10317813" ], "products": [ "species_10317815" ], "modifiers": [], "additional_components": [ "A0A6I8PRW9", "ENSXETG00000033700", "B1WAQ2", "ENSXETT00000070659", "A0A6I8PRW9", "ENSXETG00000033700", "B1WAQ2", "ENSXETT00000070659", "species_428203" ] }, "reaction_10317803": { "compartment": "compartment_984", "id": "reaction_10317803", "reactome": "R-XTR-419389", "name": "LPA-binding receptors bind LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317799", "species_417891" ], "products": [ "species_10317801" ], "modifiers": [], "additional_components": [ "ENSXETG00000039332", "species_417891", "A0A6I8RG49", "ENSXETG00000039332" ] }, "reaction_10318412": { "compartment": "compartment_984", "id": "reaction_10318412", "reactome": "R-XTR-444661", "name": "HCAR2 binds HCAR2 ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318408", "species_3296262" ], "products": [ "species_10318410" ], "modifiers": [], "additional_components": [ "ENSXETG00000033184", "CHEBI:20067", "CHEBI:15940", "CHEBI:20067", "CHEBI:15940", "A0A6I8PVP2", "ENSXETG00000033184" ] }, "reaction_10317756": { "compartment": "compartment_984", "id": "reaction_10317756", "reactome": "R-XTR-418918", "name": "The UDP/CysLT (P2Y17) receptor can bind UTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_417888", "species_10317614" ], "products": [ "species_10317754" ], "modifiers": [], "additional_components": [ "ENSXETG00000030217", "A0A6I8Q294", "ENSXETG00000030217", "species_417888" ] }, "reaction_10317705": { "compartment": "compartment_984", "id": "reaction_10317705", "reactome": "R-XTR-417927", "name": "P2Y2 receptor binds ATP and UTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317701", "species_511955" ], "products": [ "species_10317703" ], "modifiers": [], "additional_components": [ "ENSXETG00000039207", "CHEBI:15713", "species_113593", "CHEBI:15713", "species_113593", "A0A6I8T2N1", "ENSXETG00000039207" ] }, "reaction_10317752": { "compartment": "compartment_984", "id": "reaction_10317752", "reactome": "R-XTR-418904", "name": "A1 and A3 receptors bind adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317746", "species_83908" ], "products": [ "species_10317750" ], "modifiers": [], "additional_components": [ "ENSXETG00000031634", "species_8857850", "A0A6I8QZP2", "ENSXETG00000031634" ] }, "reaction_10327569": { "compartment": "compartment_876", "id": "reaction_10327569", "reactome": "R-XTR-3296309", "name": "HCAR3 binds HCAR3 ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320048", "species_3296330" ], "products": [ "species_10320050" ], "modifiers": [], "additional_components": [ "ENSXETG00000033184", "CHEBI:37098", "CHEBI:15940", "CHEBI:37098", "CHEBI:15940", "A0A6I8PVP2", "ENSXETG00000033184" ] }, "reaction_10327571": { "compartment": "compartment_876", "id": "reaction_10327571", "reactome": "R-XTR-3296326", "name": "HCAR1 binds LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_373863", "species_10320044" ], "products": [ "species_10320046" ], "modifiers": [], "additional_components": [ "ENSXETG00000033184", "A0A6I8PVP2", "ENSXETG00000033184", "species_373863" ] }, "reaction_10327567": { "compartment": "compartment_876", "id": "reaction_10327567", "reactome": "R-XTR-3296304", "name": "GPR31 is a receptor for 12(S)-HETE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320086", "species_3296298" ], "products": [ "species_10320088" ], "modifiers": [], "additional_components": [ "ENSXETG00000033184", "species_3296298", "A0A6I8PVP2", "ENSXETG00000033184" ] }, "reaction_10318324": { "compartment": "compartment_984", "id": "reaction_10318324", "reactome": "R-XTR-444047", "name": "Receptor FFAR3 binds carboxylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318320", "species_444074" ], "products": [ "species_10318322" ], "modifiers": [], "additional_components": [ "ENSXETG00000034865", "species_29460", "CHEBI:31011", "species_76179", "species_29416", "CHEBI:30768", "species_29460", "CHEBI:31011", "species_76179", "species_29416", "CHEBI:30768", "A0A6I8RL92", "ENSXETG00000034865" ] }, "reaction_10318339": { "compartment": "compartment_984", "id": "reaction_10318339", "reactome": "R-XTR-444171", "name": "Receptor FFAR2 binds carboxylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444210", "species_10318335" ], "products": [ "species_10318337" ], "modifiers": [], "additional_components": [ "species_29460", "CHEBI:17120", "CHEBI:31011", "species_76179", "species_29416", "CHEBI:30768", "ENSXETG00000034865", "A0A6I8RL92", "ENSXETG00000034865", "species_29460", "CHEBI:17120", "CHEBI:31011", "species_76179", "species_29416", "CHEBI:30768" ] }, "reaction_10327559": { "compartment": "compartment_876", "id": "reaction_10327559", "reactome": "R-XTR-3296244", "name": "SUCNR1 binds SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433123", "species_10320040" ], "products": [ "species_10320042" ], "modifiers": [], "additional_components": [ "ENSXETG00000039349", "A0A6I8S407", "ENSXETG00000039349", "species_159939" ] }, "reaction_10318406": { "compartment": "compartment_984", "id": "reaction_10318406", "reactome": "R-XTR-444572", "name": "Zinc is an agonist of GPR39", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318402", "species_158417" ], "products": [ "species_10318404" ], "modifiers": [], "additional_components": [ "ENSXETG00000036628", "species_29426", "A0A6I8RPP0", "ENSXETG00000036628" ] }, "reaction_10318432": { "compartment": "compartment_984", "id": "reaction_10318432", "reactome": "R-XTR-444731", "name": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_10318428" ], "products": [ "species_10318430" ], "modifiers": [], "additional_components": [ "F7AA76", "ENSXETT00000034427", "A0A6I8QT77", "ENSXETG00000040511", "A0A6I8PUB9", "ENSXETG00000033328", "F7AA76", "ENSXETT00000034427", "A0A6I8QT77", "ENSXETG00000040511", "A0A6I8PUB9", "ENSXETG00000033328", "species_156540" ] }, "reaction_10317644": { "compartment": "compartment_984", "id": "reaction_10317644", "reactome": "R-XTR-391942", "name": "IP receptor can bind prostacyclin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317640", "species_391926" ], "products": [ "species_10317642" ], "modifiers": [], "additional_components": [ "ENSXETG00000031128", "species_31593", "A0A6I8PVP3", "ENSXETG00000031128" ] }, "reaction_10317610": { "compartment": "compartment_984", "id": "reaction_10317610", "reactome": "R-XTR-391934", "name": "DP2 receptor can bind PGD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317606", "species_416911" ], "products": [ "species_10317608" ], "modifiers": [], "additional_components": [ "A0A6I8PVU0", "ENSXETG00000035176", "A0A6I8QNA8", "ENSXETG00000036987", "A0A6I8QGG0", "ENSXETG00000035176", "species_416911", "A0A6I8PVU0", "ENSXETG00000035176", "A0A6I8QNA8", "ENSXETG00000036987", "A0A6I8QGG0", "ENSXETG00000035176" ] }, "reaction_10317697": { "compartment": "compartment_984", "id": "reaction_10317697", "reactome": "R-XTR-416929", "name": "FP receptor can bind PGF2-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_391928", "species_10317693" ], "products": [ "species_10317695" ], "modifiers": [], "additional_components": [ "ENSXETG00000036599", "A0A6I8S7J6", "ENSXETG00000036599", "species_391928" ] }, "reaction_10317588": { "compartment": "compartment_984", "id": "reaction_10317588", "reactome": "R-XTR-391905", "name": "Oxoeicosanoid receptor can bind oxoeicosanoid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317584", "species_416428" ], "products": [ "species_10317586" ], "modifiers": [], "additional_components": [ "ENSXETG00000033184", "species_416428", "A0A6I8PVP2", "ENSXETG00000033184" ] }, "reaction_10317636": { "compartment": "compartment_984", "id": "reaction_10317636", "reactome": "R-XTR-391941", "name": "BLT receptors can bind LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317632", "species_416436" ], "products": [ "species_10317634" ], "modifiers": [], "additional_components": [ "F7B9R6", "ENSXETT00000038060", "A0A6I8S269", "ENSXETG00000036845", "species_416436", "F7B9R6", "ENSXETT00000038060", "A0A6I8S269", "ENSXETG00000036845" ] }, "reaction_10317618": { "compartment": "compartment_984", "id": "reaction_10317618", "reactome": "R-XTR-391937", "name": "UDP/CysLT receptor can bind cysteinyl leukotrienes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317614", "species_416372" ], "products": [ "species_10317616" ], "modifiers": [], "additional_components": [ "ENSXETG00000030217", "CHEBI:28666", "CHEBI:16978", "CHEBI:15650", "CHEBI:28666", "CHEBI:16978", "CHEBI:15650", "A0A6I8Q294", "ENSXETG00000030217" ] }, "reaction_10317742": { "compartment": "compartment_876", "id": "reaction_10317742", "reactome": "R-XTR-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312731" ], "products": [ "species_10317739" ], "modifiers": [ [ "species_10312731", "catalyst" ] ], "additional_components": [ "B1H2U7", "ENSXETT00000094272", "species_29438", "species_29420", "B1H2U7", "ENSXETT00000094272", "B1H2U7", "ENSXETT00000094272", "species_29438" ] }, "reaction_10317795": { "compartment": "compartment_70101", "id": "reaction_10317795", "reactome": "R-XTR-419166", "name": "GEFs activate RhoA,B,C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10317687" ], "products": [ "species_29420", "species_10317689" ], "modifiers": [ [ "species_10316070", "catalyst" ] ], "additional_components": [ "species_29420", "Q6NVL3", "ENSXETT00000056231", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8QGS5", "ENSXETG00000038787", "F7DKF6", "ENSXETT00000044021", "A4II46", "ENSXETT00000074782", "A0A6I8Q734", "ENSXETG00000009131", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10312776": { "compartment": "compartment_114521", "id": "reaction_10312776", "reactome": "R-XTR-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10312773", "catalyst" ] ], "additional_components": [ "species_114520", "species_74112", "A0A6I8QV43", "ENSXETG00000005153", "F6XEN8", "ENSXETT00000003958" ] }, "reaction_10317957": { "compartment": "compartment_70101", "id": "reaction_10317957", "reactome": "R-XTR-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_76108", "species_29370" ], "modifiers": [ [ "species_10317954", "catalyst" ] ], "additional_components": [ "A0A6I8SXY7", "ENSXETG00000014560", "A0A6I8SPG5", "ENSXETG00000005053", "F7DCA2", "ENSXETT00000006488" ] }, "reaction_10312816": { "compartment": "compartment_70101", "id": "reaction_10312816", "reactome": "R-XTR-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312771", "species_114520" ], "products": [ "species_10312773" ], "modifiers": [], "additional_components": [ "A0A6I8QV43", "ENSXETG00000005153", "F6XEN8", "ENSXETT00000003958", "species_114520", "species_74112", "A0A6I8QV43", "ENSXETG00000005153", "F6XEN8", "ENSXETT00000003958" ] }, "reaction_10331377": { "compartment": "compartment_876", "id": "reaction_10331377", "reactome": "R-XTR-5694462", "name": "ABHD6,12 hydrolyse 3AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694509" ], "products": [ "species_422506", "species_70106", "species_76116" ], "modifiers": [ [ "species_10331374", "catalyst" ] ], "additional_components": [ "ENSXETG00000012789" ] }, "reaction_10326350": { "compartment": "compartment_70101", "id": "reaction_10326350", "reactome": "R-XTR-2179415", "name": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312049", "species_10326342" ], "products": [ "species_10326348" ], "modifiers": [], "additional_components": [ "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387", "A0A6I8QCY1", "ENSXETG00000039798", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "F7C8B9", "ENSXETT00000006761", "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10326344": { "compartment": "compartment_984", "id": "reaction_10326344", "reactome": "R-XTR-2179387", "name": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313820", "species_10313836" ], "products": [ "species_10326342" ], "modifiers": [], "additional_components": [ "ENSXETT00000006761", "ENSXETG00000039798", "A0A6I8QCY1", "ENSXETG00000039798", "F7C8B9", "ENSXETT00000006761" ] }, "reaction_10320122": { "compartment": "compartment_984", "id": "reaction_10320122", "reactome": "R-XTR-870269", "name": "Gastrin binds to CCK-B receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10319126", "species_10319130" ], "products": [ "species_10319132" ], "modifiers": [], "additional_components": [ "ENSXETT00000050945", "ENSXETT00000027311", "F6W277", "ENSXETT00000027311", "F6ZEU0", "ENSXETT00000050945" ] }, "reaction_10317737": { "compartment": "compartment_70101", "id": "reaction_10317737", "reactome": "R-XTR-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10317734", "catalyst" ] ], "additional_components": [ "F6T8H7", "ENSXETT00000040889", "A0A6I8SHT5", "ENSXETG00000011637" ] }, "reaction_10338257": { "compartment": "compartment_70101", "id": "reaction_10338257", "reactome": "R-XTR-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10312595", "catalyst" ] ], "additional_components": [ "ENSXETG00000011637" ] }, "reaction_10337052": { "compartment": "compartment_876", "id": "reaction_10337052", "reactome": "R-XTR-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337050" ], "products": [ "species_10320096", "species_10337048" ], "modifiers": [], "additional_components": [ "F7ANT3", "ENSXETT00000036860", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236", "species_29420", "F7ANT3", "ENSXETT00000036860", "species_29420", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236" ] }, "reaction_10312560": { "compartment": "compartment_70101", "id": "reaction_10312560", "reactome": "R-XTR-111881", "name": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_10312556", "species_74016" ], "products": [ "species_10312558" ], "modifiers": [], "additional_components": [ "ENSXETT00000066288", "B1WAZ6", "ENSXETT00000066288", "species_74112", "species_426925" ] }, "reaction_10312598": { "compartment": "compartment_70101", "id": "reaction_10312598", "reactome": "R-XTR-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10312595", "catalyst" ] ], "additional_components": [ "ENSXETG00000011637" ] }, "reaction_10337061": { "compartment": "compartment_876", "id": "reaction_10337061", "reactome": "R-XTR-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337056" ], "products": [ "species_29372", "species_10337050" ], "modifiers": [ [ "species_10337056", "catalyst" ] ], "additional_components": [ "F7ANT3", "ENSXETT00000036860", "species_29438", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236", "F7ANT3", "ENSXETT00000036860", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236", "species_29420", "F7ANT3", "ENSXETT00000036860", "species_29438", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236" ] }, "reaction_10337058": { "compartment": "compartment_876", "id": "reaction_10337058", "reactome": "R-XTR-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337048", "species_10337054" ], "products": [ "species_10337056" ], "modifiers": [], "additional_components": [ "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236", "F7ANT3", "ENSXETT00000036860", "species_29438", "F7ANT3", "ENSXETT00000036860", "species_29438", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236" ] }, "reaction_10318153": { "compartment": "compartment_876", "id": "reaction_10318153", "reactome": "R-XTR-432067", "name": "Aquaporin-4 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10318150", "catalyst" ] ], "additional_components": [ "A0A6I8PZD7", "ENSXETG00000033655" ] }, "reaction_10318981": { "compartment": "compartment_876", "id": "reaction_10318981", "reactome": "R-XTR-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10318974", "catalyst" ] ], "additional_components": [ "A0A6I8Q4T0", "ENSXETG00000002150", "A0A6I8PZD7", "ENSXETG00000033655" ] }, "reaction_10318983": { "compartment": "compartment_876", "id": "reaction_10318983", "reactome": "R-XTR-507871", "name": "Aquaporins passively transport glycerol out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10318159", "catalyst" ] ], "additional_components": [ "A0A6I8Q4T0", "ENSXETG00000002150" ] }, "reaction_10318977": { "compartment": "compartment_876", "id": "reaction_10318977", "reactome": "R-XTR-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10318974", "catalyst" ] ], "additional_components": [ "A0A6I8Q4T0", "ENSXETG00000002150", "A0A6I8PZD7", "ENSXETG00000033655" ] }, "reaction_10318979": { "compartment": "compartment_876", "id": "reaction_10318979", "reactome": "R-XTR-507869", "name": "Aquaporins passively transport glycerol into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192438" ], "products": [ "species_76116" ], "modifiers": [ [ "species_10318159", "catalyst" ] ], "additional_components": [ "A0A6I8Q4T0", "ENSXETG00000002150" ] }, "reaction_10318162": { "compartment": "compartment_876", "id": "reaction_10318162", "reactome": "R-XTR-432074", "name": "Aquaporin-7 passively transports glycerol out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10318159", "catalyst" ] ], "additional_components": [ "A0A6I8Q4T0", "ENSXETG00000002150" ] }, "reaction_10336143": { "compartment": "compartment_7660", "id": "reaction_10336143", "reactome": "R-XTR-8936584", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336130", "species_77087" ], "products": [ "species_77502", "species_10336140" ], "modifiers": [ [ "species_10336130", "catalyst" ] ], "additional_components": [ "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10336152": { "compartment": "compartment_7660", "id": "reaction_10336152", "reactome": "R-XTR-8936608", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10336147" ], "products": [ "species_77502", "species_10336149" ], "modifiers": [ [ "species_10336147", "catalyst" ] ], "additional_components": [ "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10336170": { "compartment": "compartment_7660", "id": "reaction_10336170", "reactome": "R-XTR-8937113", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10336165" ], "products": [ "species_77502", "species_10336167" ], "modifiers": [ [ "species_10336165", "catalyst" ] ], "additional_components": [ "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10336161": { "compartment": "compartment_7660", "id": "reaction_10336161", "reactome": "R-XTR-8937022", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10336156" ], "products": [ "species_77502", "species_10336158" ], "modifiers": [ [ "species_10336156", "catalyst" ] ], "additional_components": [ "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10326663": { "compartment": "compartment_70101", "id": "reaction_10326663", "reactome": "R-XTR-2316434", "name": "PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10326660", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "A0A6I8RUB1", "ENSXETG00000007252", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "species_179838", "A0A6I8RAF1", "ENSXETG00000039550", "A0A6I8Q186", "ENSXETG00000012933" ] }, "reaction_10316685": { "compartment": "compartment_70101", "id": "reaction_10316685", "reactome": "R-XTR-350319", "name": "Caspase mediated cleavage of vimentin at IDVD (259)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315647" ], "products": [ "species_10316674", "species_10316672" ], "modifiers": [ [ "species_10316682", "catalyst" ] ], "additional_components": [ "ENSXETG00000007462", "ENSXETG00000007462", "ENSXETG00000007462", "A0A6I8Q0P2", "ENSXETG00000032748" ] }, "reaction_10315899": { "compartment": "compartment_70101", "id": "reaction_10315899", "reactome": "R-XTR-202967", "name": "Caspase mediated cleavage of alpha-II-Fodrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315893" ], "products": [ "species_10315895", "species_10315897" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000012869", "ENSXETG00000012869", "ENSXETG00000012869", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10315654": { "compartment": "compartment_70101", "id": "reaction_10315654", "reactome": "R-XTR-201628", "name": "Caspase-mediated cleavage of vimentin at DSVD (85)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315647" ], "products": [ "species_10315651", "species_10315649" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000007462", "ENSXETG00000007462", "ENSXETG00000007462", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10315889": { "compartment": "compartment_70101", "id": "reaction_10315889", "reactome": "R-XTR-202966", "name": "Caspase mediated cleavage of HIP-55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315883" ], "products": [ "species_10315887", "species_10315885" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000019013", "ENSXETG00000019013", "ENSXETG00000019013", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10315664": { "compartment": "compartment_70101", "id": "reaction_10315664", "reactome": "R-XTR-201629", "name": "Caspase-mediated cleavage of Tau", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315658" ], "products": [ "species_10315662", "species_10315660" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000001624", "ENSXETG00000001624", "ENSXETG00000001624", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10322285": { "compartment": "compartment_70101", "id": "reaction_10322285", "reactome": "R-XTR-1247668", "name": "Hemoglobin A binds O2, releasing H+ and CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_10322281" ], "products": [ "species_70106", "species_113528", "species_10322261" ], "modifiers": [], "additional_components": [ "species_189444", "P07428", "ENSXETT00000002494", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494", "species_113533", "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566" ] }, "reaction_10322216": { "compartment": "compartment_984", "id": "reaction_10322216", "reactome": "R-XTR-1237059", "name": "CA4:Zn2+ dehydrates HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10322211", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8QID1", "ENSXETG00000034545" ] }, "reaction_10314265": { "compartment": "compartment_13231", "id": "reaction_10314265", "reactome": "R-XTR-193691", "name": "NF-kB migrates to the nucleus and turns on transcription", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313343" ], "products": [ "species_10313349" ], "modifiers": [], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173" ] }, "reaction_10318346": { "compartment": "compartment_876", "id": "reaction_10318346", "reactome": "R-XTR-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10318343", "catalyst" ] ], "additional_components": [ "ENSXETG00000017762" ] }, "reaction_10318353": { "compartment": "compartment_876", "id": "reaction_10318353", "reactome": "R-XTR-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10318350", "catalyst" ] ], "additional_components": [ "ENSXETG00000019898" ] }, "reaction_10318497": { "compartment": "compartment_876", "id": "reaction_10318497", "reactome": "R-XTR-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10318343", "catalyst" ] ], "additional_components": [ "ENSXETG00000017762" ] }, "reaction_10318499": { "compartment": "compartment_876", "id": "reaction_10318499", "reactome": "R-XTR-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10318350", "catalyst" ] ], "additional_components": [ "ENSXETG00000019898" ] }, "reaction_10328233": { "compartment": "compartment_7660", "id": "reaction_10328233", "reactome": "R-XTR-3782655", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10328125" ], "products": [ "species_10328131", "species_5566518" ], "modifiers": [ [ "species_10328230", "catalyst" ] ], "additional_components": [ "A0A6I8RKR7", "ENSXETG00000035354", "ENSXETG00000031474" ] }, "reaction_10328226": { "compartment": "compartment_7660", "id": "reaction_10328226", "reactome": "R-XTR-3782637", "name": "HDAC8 deacetylates histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10328125" ], "products": [ "species_10328131", "species_5566518" ], "modifiers": [ [ "species_10328223", "catalyst" ] ], "additional_components": [ "A0A6I8RKR7", "ENSXETG00000035354", "ENSXETT00000044353" ] }, "reaction_10317294": { "compartment": "compartment_984", "id": "reaction_10317294", "reactome": "R-XTR-383313", "name": "Glucagon-like Peptide 1 is secreted from intestinal L cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317286" ], "products": [ "species_10317231" ], "modifiers": [ [ "species_10317292", "catalyst" ], [ "species_70115", "catalyst" ], [ "species_372533", "catalyst" ], [ "species_10317040", "catalyst" ] ], "additional_components": [ "ENSXETT00000028848", "ENSXETT00000028848", "ENSXETG00000038809", "ENSXETT00000045737" ] }, "reaction_10317907": { "compartment": "compartment_17957", "id": "reaction_10317907", "reactome": "R-XTR-421416", "name": "Proglucagon translocates from the ER Lumen to secretory granules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317903" ], "products": [ "species_10317905" ], "modifiers": [], "additional_components": [ "ENSXETT00000028848", "ENSXETT00000028848" ] }, "reaction_10317913": { "compartment": "compartment_17957", "id": "reaction_10317913", "reactome": "R-XTR-421426", "name": "ProGIP translocates from the ER Lumen to secretory granules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317909" ], "products": [ "species_10317911" ], "modifiers": [], "additional_components": [ "ENSXETT00000062069", "ENSXETT00000062069" ] }, "reaction_10317675": { "compartment": "compartment_984", "id": "reaction_10317675", "reactome": "R-XTR-400509", "name": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317671" ], "products": [ "species_10317673" ], "modifiers": [], "additional_components": [ "ENSXETT00000062069", "ENSXETT00000062069" ] }, "reaction_10313060": { "compartment": "compartment_20699", "id": "reaction_10313060", "reactome": "R-XTR-159796", "name": "Furin cleaves pro-factor IX to factor IX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313049" ], "products": [ "species_10313051", "species_10313053" ], "modifiers": [ [ "species_10313057", "catalyst" ] ], "additional_components": [ "ENSXETT00000025939", "ENSXETT00000025939", "ENSXETT00000025939", "ENSXETG00000015462" ] }, "reaction_10334519": { "compartment": "compartment_20699", "id": "reaction_10334519", "reactome": "R-XTR-6807224", "name": "Furin cleaves pro-BGLAP to BGLAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334513" ], "products": [ "species_10334515", "species_10334517" ], "modifiers": [ [ "species_10313057", "catalyst" ] ], "additional_components": [ "ENSXETT00000005554", "ENSXETT00000005554", "ENSXETT00000005554", "ENSXETG00000015462" ] }, "reaction_10313171": { "compartment": "compartment_20699", "id": "reaction_10313171", "reactome": "R-XTR-163798", "name": "Furin cleaves pro-protein Z to protein Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313165" ], "products": [ "species_10313169", "species_10313167" ], "modifiers": [ [ "species_10313057", "catalyst" ] ], "additional_components": [ "ENSXETT00000025939", "ENSXETT00000025939", "ENSXETT00000025939", "ENSXETG00000015462" ] }, "reaction_10322355": { "compartment": "compartment_876", "id": "reaction_10322355", "reactome": "R-XTR-1296046", "name": "KCNJs transport K+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126" ], "products": [ "species_29804" ], "modifiers": [ [ "species_10322352", "catalyst" ] ], "additional_components": [ "Q0IJ30", "ENSXETT00000049657" ] }, "reaction_10315917": { "compartment": "compartment_70101", "id": "reaction_10315917", "reactome": "R-XTR-203070", "name": "Association of profilin with monomeric actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315905", "species_10315913" ], "products": [ "species_10315915" ], "modifiers": [], "additional_components": [ "Q6P378", "ENSXETT00000057558", "species_113593", "Q6P378", "ENSXETT00000057558", "species_113593" ] }, "reaction_10328317": { "compartment": "compartment_70101", "id": "reaction_10328317", "reactome": "R-XTR-3858489", "name": "ppDVL binds DAAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328291", "species_10328313" ], "products": [ "species_10328315" ], "modifiers": [], "additional_components": [ "Q05AS8", "ENSXETG00000017212", "ENSXETG00000017030", "A0A6I8SJ25", "ENSXETG00000017030", "Q05AS8", "ENSXETG00000017212" ] }, "reaction_10330409": { "compartment": "compartment_70101", "id": "reaction_10330409", "reactome": "R-XTR-5666070", "name": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330405", "species_10330399" ], "products": [ "species_10330407" ], "modifiers": [], "additional_components": [ "A0A6I8RD71", "ENSXETG00000018144", "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8RD71", "ENSXETG00000018144" ] }, "reaction_10329929": { "compartment": "compartment_876", "id": "reaction_10329929", "reactome": "R-XTR-5623622", "name": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329921", "species_10329925" ], "products": [ "species_10329927" ], "modifiers": [], "additional_components": [ "A0A6I8R6D3", "ENSXETG00000006092", "A0A6I8PK39", "ENSXETG00000039434", "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8R6D3", "ENSXETG00000006092", "A0A6I8PK39", "ENSXETG00000039434" ] }, "reaction_10329945": { "compartment": "compartment_7660", "id": "reaction_10329945", "reactome": "R-XTR-5625717", "name": "Phosphorylated PKN1 binds androgen receptor (AR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329937", "species_10329941" ], "products": [ "species_10329943" ], "modifiers": [], "additional_components": [ "ENSXETG00000039434", "species_30321", "CHEBI:16422", "species_469662", "CHEBI:29117", "A0A6I8RK73", "ENSXETG00000005089", "species_30321", "CHEBI:16422", "species_469662", "CHEBI:29117", "A0A6I8RK73", "ENSXETG00000005089", "A0A6I8PK39", "ENSXETG00000039434" ] }, "reaction_10329961": { "compartment": "compartment_7660", "id": "reaction_10329961", "reactome": "R-XTR-5625745", "name": "PKN1 stimulates association of AR with NCOA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329957", "species_10329951" ], "products": [ "species_10329959" ], "modifiers": [], "additional_components": [ "ENSXETG00000015926", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "B5DE09", "ENSXETG00000015926" ] }, "reaction_10329973": { "compartment": "compartment_7660", "id": "reaction_10329973", "reactome": "R-XTR-5625774", "name": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329969", "species_10329951" ], "products": [ "species_10329971" ], "modifiers": [], "additional_components": [ "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10330023": { "compartment": "compartment_7660", "id": "reaction_10330023", "reactome": "R-XTR-5625848", "name": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10330008", "species_113685" ], "products": [ "species_10330020", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10330008", "catalyst" ] ], "additional_components": [ "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803" ] }, "reaction_10329990": { "compartment": "compartment_7660", "id": "reaction_10329990", "reactome": "R-XTR-5625784", "name": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10329971" ], "products": [ "species_113582", "species_10329987" ], "modifiers": [ [ "species_10329971", "catalyst" ] ], "additional_components": [ "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10329953": { "compartment": "compartment_70101", "id": "reaction_10329953", "reactome": "R-XTR-5625738", "name": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329943" ], "products": [ "species_10329951" ], "modifiers": [], "additional_components": [ "species_30321", "CHEBI:16422", "species_469662", "CHEBI:29117", "A0A6I8RK73", "ENSXETG00000005089", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434" ] }, "reaction_10330047": { "compartment": "compartment_70101", "id": "reaction_10330047", "reactome": "R-XTR-5626507", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330039", "species_10330043" ], "products": [ "species_10330045" ], "modifiers": [], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8S827", "ENSXETG00000020384", "Q6P378", "ENSXETT00000057558", "species_113593", "Q6P378", "ENSXETT00000057558", "species_113593", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8S827", "ENSXETG00000020384" ] }, "reaction_10330041": { "compartment": "compartment_70101", "id": "reaction_10330041", "reactome": "R-XTR-5626469", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330037", "species_10312717" ], "products": [ "species_10330039" ], "modifiers": [], "additional_components": [ "A0A6I8S827", "ENSXETG00000020384", "Q6GL60", "ENSXETT00000092508", "species_29438", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8S827", "ENSXETG00000020384" ] }, "reaction_10337088": { "compartment": "compartment_5460", "id": "reaction_10337088", "reactome": "R-XTR-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337081" ], "products": [], "modifiers": [ [ "species_10337085", "catalyst" ] ], "additional_components": [ "A0A6I8SHX8", "ENSXETG00000041384", "ENSXETG00000009818" ] }, "reaction_10329865": { "compartment": "compartment_24337", "id": "reaction_10329865", "reactome": "R-XTR-5610763", "name": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329855" ], "products": [ "species_10329859" ], "modifiers": [ [ "species_10329863", "inhibitor" ] ], "additional_components": [ "A0A6I8RRT2", "ENSXETG00000014939", "A0A6I8RRT2", "ENSXETG00000014939", "ENSXETG00000014834" ] }, "reaction_10329849": { "compartment": "compartment_876", "id": "reaction_10329849", "reactome": "R-XTR-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10329846", "catalyst" ] ], "additional_components": [ "species_109496" ] }, "reaction_10330636": { "compartment": "compartment_7660", "id": "reaction_10330636", "reactome": "R-XTR-5683831", "name": "CCDC59 binds TTF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330628", "species_10330632" ], "products": [ "species_10330634" ], "modifiers": [], "additional_components": [ "ENSXETT00000031815", "ENSXETG00000040672", "A0A6I8R1F2", "ENSXETG00000040672", "F6XAD1", "ENSXETT00000031815" ] }, "reaction_10330828": { "compartment": "compartment_876", "id": "reaction_10330828", "reactome": "R-XTR-5686286", "name": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330816" ], "products": [ "species_10330826" ], "modifiers": [], "additional_components": [ "A0A6I8SVN5", "ENSXETG00000009325", "F6ULZ5", "ENSXETT00000023447", "F6ULZ5", "ENSXETT00000023447", "A0A6I8SVN5", "ENSXETG00000009325" ] }, "reaction_10337007": { "compartment": "compartment_12045", "id": "reaction_10337007", "reactome": "R-XTR-8961021", "name": "SFTPD binds with itself to form SFTPD 12mer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337003" ], "products": [ "species_10337005" ], "modifiers": [], "additional_components": [ "A0A6I8R9D1", "ENSXETG00000034779", "A0A6I8R9D1", "ENSXETG00000034779" ] }, "reaction_10330798": { "compartment": "compartment_12045", "id": "reaction_10330798", "reactome": "R-XTR-5685649", "name": "SFTPAs translocate from ER membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330794" ], "products": [ "species_10330796" ], "modifiers": [], "additional_components": [ "A0A6I8SVN5", "ENSXETG00000009325", "A0A6I8SVN5", "ENSXETG00000009325" ] }, "reaction_10330830": { "compartment": "compartment_876", "id": "reaction_10330830", "reactome": "R-XTR-5686301", "name": "PALM-C100-CKAP4 binds SFTPAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330814", "species_10330796" ], "products": [ "species_10330816" ], "modifiers": [], "additional_components": [ "ENSXETT00000023447", "A0A6I8SVN5", "ENSXETG00000009325", "A0A6I8SVN5", "ENSXETG00000009325", "F6ULZ5", "ENSXETT00000023447" ] }, "reaction_10330809": { "compartment": "compartment_3828046", "id": "reaction_10330809", "reactome": "R-XTR-5685902", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5685882", "species_10330697" ], "products": [ "species_10330802", "species_10330800" ], "modifiers": [ [ "species_10330806", "catalyst" ] ], "additional_components": [ "ENSXETG00000031314", "ENSXETG00000031314", "ENSXETG00000031314", "ENSXETT00000003012" ] }, "reaction_10331288": { "compartment": "compartment_984", "id": "reaction_10331288", "reactome": "R-XTR-5693346", "name": "CECRI deaminates Ade-Rib to Ino", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_83908" ], "products": [ "species_2022135", "species_83921" ], "modifiers": [ [ "species_10331285", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8QUN5", "ENSXETG00000039169" ] }, "reaction_10330699": { "compartment": "compartment_12045", "id": "reaction_10330699", "reactome": "R-XTR-5684868", "name": "pro-SFTPC translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330695" ], "products": [ "species_10330697" ], "modifiers": [], "additional_components": [ "ENSXETG00000031314", "ENSXETG00000031314" ] }, "reaction_10337812": { "compartment": "compartment_12045", "id": "reaction_10337812", "reactome": "R-XTR-9624778", "name": "SFTPD 12mer translocates from ER membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337005" ], "products": [ "species_10337810" ], "modifiers": [], "additional_components": [ "A0A6I8R9D1", "ENSXETG00000034779", "A0A6I8R9D1", "ENSXETG00000034779" ] }, "reaction_10336078": { "compartment": "compartment_70101", "id": "reaction_10336078", "reactome": "R-XTR-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336068", "species_71284" ], "products": [ "species_10336071", "species_71285" ], "modifiers": [ [ "species_10336075", "catalyst" ] ], "additional_components": [ "ENSXETT00000067185", "ENSXETT00000067185", "ENSXETG00000037439" ] }, "reaction_10336088": { "compartment": "compartment_70101", "id": "reaction_10336088", "reactome": "R-XTR-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312906", "species_71284" ], "products": [ "species_10336081", "species_71285" ], "modifiers": [ [ "species_10336085", "catalyst" ] ], "additional_components": [ "ENSXETG00000037123", "ENSXETG00000037123", "ENSXETG00000030721" ] }, "reaction_10336059": { "compartment": "compartment_70101", "id": "reaction_10336059", "reactome": "R-XTR-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312906", "species_71284" ], "products": [ "species_10336052", "species_71285" ], "modifiers": [ [ "species_10336056", "catalyst" ] ], "additional_components": [ "ENSXETG00000037123", "ENSXETG00000037123", "ENSXETG00000033485" ] }, "reaction_10313177": { "compartment": "compartment_13959", "id": "reaction_10313177", "reactome": "R-XTR-163825", "name": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313175" ], "products": [ "species_10313165" ], "modifiers": [], "additional_components": [ "ENSXETT00000025939", "ENSXETT00000025939" ] }, "reaction_10334521": { "compartment": "compartment_13959", "id": "reaction_10334521", "reactome": "R-XTR-6807229", "name": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334511" ], "products": [ "species_10334513" ], "modifiers": [], "additional_components": [ "ENSXETT00000005554", "ENSXETT00000005554" ] }, "reaction_10313066": { "compartment": "compartment_13959", "id": "reaction_10313066", "reactome": "R-XTR-159836", "name": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313064" ], "products": [ "species_10313049" ], "modifiers": [], "additional_components": [ "ENSXETT00000025939", "ENSXETT00000025939" ] }, "reaction_10316020": { "compartment": "compartment_70101", "id": "reaction_10316020", "reactome": "R-XTR-204617", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_10316005", "species_204628", "species_73473" ], "products": [ "species_204635", "species_10316009", "species_29360" ], "modifiers": [ [ "species_10316017", "catalyst" ] ], "additional_components": [ "ENSXETG00000034500", "ENSXETG00000034500", "F6RYK2", "ENSXETT00000012343" ] }, "reaction_10316036": { "compartment": "compartment_70101", "id": "reaction_10316036", "reactome": "R-XTR-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_10316005", "species_29368", "species_73473" ], "products": [ "species_29356", "species_10316025", "species_29360" ], "modifiers": [ [ "species_10316033", "catalyst" ] ], "additional_components": [ "ENSXETG00000034500", "ENSXETG00000034500", "A0A6I8SV44", "ENSXETG00000040489", "species_435347" ] }, "reaction_10338051": { "compartment": "compartment_17963", "id": "reaction_10338051", "reactome": "R-XTR-9668023", "name": "TPST1,2 transfer SO4(2-) from PAPS to FVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10338041" ], "products": [ "species_10338049", "species_742343" ], "modifiers": [ [ "species_10336936", "catalyst" ] ], "additional_components": [ "ENSXETG00000038196", "ENSXETG00000038196", "ENSXETG00000017664" ] }, "reaction_10321802": { "compartment": "compartment_70101", "id": "reaction_10321802", "reactome": "R-XTR-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321798" ], "products": [ "species_10321800" ], "modifiers": [], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "CHEBI:60627", "CHEBI:60628", "CHEBI:59092", "CHEBI:60629", "CHEBI:59087", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858" ] }, "reaction_10335136": { "compartment": "compartment_70101", "id": "reaction_10335136", "reactome": "R-XTR-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10321800" ], "products": [ "species_8853371", "species_8853381" ], "modifiers": [ [ "species_10335133", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "CHEBI:59092", "CHEBI:60629", "CHEBI:59087", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "CHEBI:91280", "CHEBI:91284", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "ENSXETT00000043623" ] }, "reaction_10328409": { "compartment": "compartment_17963", "id": "reaction_10328409", "reactome": "R-XTR-4084984", "name": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_4086285" ], "products": [ "species_4086277", "species_727810" ], "modifiers": [ [ "species_10325929", "catalyst" ] ], "additional_components": [ "ENSXETG00000026104" ] }, "reaction_10328407": { "compartment": "compartment_20699", "id": "reaction_10328407", "reactome": "R-XTR-4084978", "name": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_4088006" ], "products": [ "species_727810", "species_4087982" ], "modifiers": [ [ "species_10328404", "catalyst" ] ], "additional_components": [ "A0A6I8Q045", "ENSXETG00000024127", "A1KQY5", "ENSXETT00000075006", "Q6DNG6", "ENSXETG00000023481", "A0A6I8QSS5", "ENSXETG00000035254", "A0A6I8S6X4", "ENSXETG00000039548" ] }, "reaction_10328418": { "compartment": "compartment_70101", "id": "reaction_10328418", "reactome": "R-XTR-4085217", "name": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4088096" ], "products": [ "species_4088099", "species_29398" ], "modifiers": [ [ "species_10328415", "catalyst" ] ], "additional_components": [ "species_975925", "CHEBI:29025", "CHEBI:17122", "CHEBI:28255", "Q5M905", "ENSXETT00000033244" ] }, "reaction_10333998": { "compartment": "compartment_70101", "id": "reaction_10333998", "reactome": "R-XTR-6803771", "name": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803785", "species_113592" ], "products": [ "species_6803738", "species_70106", "species_29370" ], "modifiers": [ [ "species_10333995", "catalyst" ] ], "additional_components": [ "CHEBI:27459", "species_1678743", "CHEBI:15784", "CHEBI:88130", "A0A5K1VLH5", "ENSXETT00000012241" ] }, "reaction_10318563": { "compartment": "compartment_70101", "id": "reaction_10318563", "reactome": "R-XTR-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512", "species_29472" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10318560", "catalyst" ] ], "additional_components": [ "ENSXETT00000029938" ] }, "reaction_10319089": { "compartment": "compartment_20699", "id": "reaction_10319089", "reactome": "R-XTR-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10319086", "catalyst" ] ], "additional_components": [ "ENSXETG00000036219" ] }, "reaction_10332336": { "compartment": "compartment_70101", "id": "reaction_10332336", "reactome": "R-XTR-6787540", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6787678" ], "products": [ "species_29370", "species_6787542" ], "modifiers": [ [ "species_10332333", "catalyst" ] ], "additional_components": [ "ENSXETG00000040982" ] }, "reaction_10320776": { "compartment": "compartment_20699", "id": "reaction_10320776", "reactome": "R-XTR-975916", "name": "Addition of GlcNAc to position 5 by MGAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981617" ], "modifiers": [ [ "species_10320773", "catalyst" ] ], "additional_components": [ "ENSXETG00000000514" ] }, "reaction_10321819": { "compartment": "compartment_20699", "id": "reaction_10321819", "reactome": "R-XTR-1022133", "name": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975925", "species_975910" ], "products": [ "species_981615" ], "modifiers": [ [ "species_10321816", "catalyst" ] ], "additional_components": [ "A0A6I8Q045", "ENSXETG00000024127", "A0A6I8QSS5", "ENSXETG00000035254", "Q6DNG6", "ENSXETG00000023481" ] }, "reaction_10320769": { "compartment": "compartment_20699", "id": "reaction_10320769", "reactome": "R-XTR-975903", "name": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981616" ], "modifiers": [ [ "species_10320766", "catalyst" ] ], "additional_components": [ "ENSXETG00000019401" ] }, "reaction_10320785": { "compartment": "compartment_20699", "id": "reaction_10320785", "reactome": "R-XTR-975919", "name": "Addition of galactose by beta 4-galactosyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_975910" ], "products": [ "species_981618" ], "modifiers": [ [ "species_10320782", "catalyst" ] ], "additional_components": [ "A0A6I8QS90", "ENSXETG00000034513" ] }, "reaction_10320729": { "compartment": "compartment_17963", "id": "reaction_10320729", "reactome": "R-XTR-964759", "name": "Alternative endo-mannosidase I route", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964754" ], "products": [ "species_964744", "species_964746" ], "modifiers": [ [ "species_10320726", "catalyst" ] ], "additional_components": [ "ENSXETG00000038826" ] }, "reaction_10335243": { "compartment": "compartment_984", "id": "reaction_10335243", "reactome": "R-XTR-8855711", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855720", "species_10335239" ], "products": [ "species_10335241" ], "modifiers": [], "additional_components": [ "A0A6I8Q6M7", "ENSXETG00000041320", "A0A6I8Q6M7", "ENSXETG00000041320", "species_8855720" ] }, "reaction_10335258": { "compartment": "compartment_20699", "id": "reaction_10335258", "reactome": "R-XTR-8855954", "name": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335248", "species_735682" ], "products": [ "species_10335251", "species_205687" ], "modifiers": [ [ "species_10335255", "catalyst" ] ], "additional_components": [ "ENSXETG00000037485", "ENSXETG00000037485", "ENSXETG00000033376" ] }, "reaction_10335149": { "compartment": "compartment_70101", "id": "reaction_10335149", "reactome": "R-XTR-8853529", "name": "OTULIN,USP5 cleaves UBB yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335147" ], "products": [ "species_10312090", "species_10312094", "species_10312092" ], "modifiers": [ [ "species_10335142", "catalyst" ] ], "additional_components": [ "ENSXETG00000037858", "ENSXETG00000037858", "ENSXETG00000037858", "ENSXETG00000037858", "ENSXETT00000003610" ] }, "reaction_10335145": { "compartment": "compartment_70101", "id": "reaction_10335145", "reactome": "R-XTR-8853515", "name": "OTULIN,USP5 cleaves UBC yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335138" ], "products": [ "species_10312114", "species_10312098", "species_10312112", "species_10312102", "species_10312100", "species_10312106", "species_10312104", "species_10312110", "species_10312108" ], "modifiers": [ [ "species_10335142", "catalyst" ] ], "additional_components": [ "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETT00000003610" ] }, "reaction_10313091": { "compartment": "compartment_17957", "id": "reaction_10313091", "reactome": "R-XTR-162729", "name": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_10313078" ], "products": [ "species_1524021", "species_10313084" ], "modifiers": [ [ "species_10313088", "catalyst" ] ], "additional_components": [ "A0A6I8PQQ3", "ENSXETG00000033079", "A0A6I8SLF2", "ENSXETG00000037404", "A0A6I8PQQ3", "ENSXETG00000033079", "A0A6I8SLF2", "ENSXETG00000037404", "ENSXETG00000034065" ] }, "reaction_10313104": { "compartment": "compartment_12045", "id": "reaction_10313104", "reactome": "R-XTR-162742", "name": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855660" ], "products": [ "species_8855660" ], "modifiers": [ [ "species_10313101", "catalyst" ] ], "additional_components": [ "A0A6I8QRW2", "ENSXETG00000003720", "B7ZT49", "ENSXETT00000055317" ] }, "reaction_10313123": { "compartment": "compartment_70101", "id": "reaction_10313123", "reactome": "R-XTR-162857", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855657", "species_29356" ], "products": [ "species_8855661", "species_29416" ], "modifiers": [ [ "species_10313120", "catalyst" ] ], "additional_components": [ "ENSXETG00000038618" ] }, "reaction_10327110": { "compartment": "compartment_7660", "id": "reaction_10327110", "reactome": "R-XTR-2990833", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10327093", "species_10327097" ], "products": [ "species_10327107", "species_164121", "species_113541" ], "modifiers": [ [ "species_10327093", "catalyst" ] ], "additional_components": [ "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374", "ENSXETG00000022072", "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374", "Q6DEP7", "ENSXETG00000022072", "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374" ] }, "reaction_10327143": { "compartment": "compartment_7660", "id": "reaction_10327143", "reactome": "R-XTR-2993780", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327107", "species_10327128" ], "products": [ "species_10327136", "species_10327093" ], "modifiers": [ [ "species_10327093", "catalyst" ], [ "species_10327141", "catalyst" ] ], "additional_components": [ "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374", "Q6DEP7", "ENSXETG00000022072", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374", "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374", "ENSXETG00000025843" ] }, "reaction_10325469": { "compartment": "compartment_984", "id": "reaction_10325469", "reactome": "R-XTR-2022411", "name": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10325445" ], "products": [ "species_10316956" ], "modifiers": [ [ "species_10325464", "catalyst" ] ], "additional_components": [ "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "ENSXETT00000037000" ] }, "reaction_10325439": { "compartment": "compartment_984", "id": "reaction_10325439", "reactome": "R-XTR-2022368", "name": "Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325426", "species_109276" ], "products": [ "species_10325432" ], "modifiers": [ [ "species_10325436", "catalyst" ] ], "additional_components": [ "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "ENSXETG00000007771" ] }, "reaction_10325448": { "compartment": "compartment_984", "id": "reaction_10325448", "reactome": "R-XTR-2022383", "name": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10325445" ], "products": [ "species_10316956" ], "modifiers": [ [ "species_10323745", "catalyst" ] ], "additional_components": [ "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "ENSXETT00000037000" ] }, "reaction_10325450": { "compartment": "compartment_984", "id": "reaction_10325450", "reactome": "R-XTR-2022396", "name": "Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10325445" ], "products": [ "species_10325432" ], "modifiers": [ [ "species_10325436", "catalyst" ] ], "additional_components": [ "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "ENSXETG00000007771" ] }, "reaction_10337782": { "compartment": "compartment_984", "id": "reaction_10337782", "reactome": "R-XTR-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10331304", "catalyst" ] ], "additional_components": [ "A0A5G3JDL4", "ENSXETT00000103127" ] }, "reaction_10325793": { "compartment": "compartment_984", "id": "reaction_10325793", "reactome": "R-XTR-2028294", "name": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10325445" ], "products": [ "species_10325426" ], "modifiers": [ [ "species_10325790", "catalyst" ] ], "additional_components": [ "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "A0A6I8PU97", "ENSXETG00000033023" ] }, "reaction_10317212": { "compartment": "compartment_984", "id": "reaction_10317212", "reactome": "R-XTR-381412", "name": "IGFBP2 binds IGF forming IGF:IGFBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317204", "species_10317208" ], "products": [ "species_10317210" ], "modifiers": [], "additional_components": [ "ENSXETT00000094605", "ENSXETT00000006287", "F7CZB7", "ENSXETT00000006287", "A4IIA2", "ENSXETT00000094605" ] }, "reaction_10317228": { "compartment": "compartment_984", "id": "reaction_10317228", "reactome": "R-XTR-381545", "name": "Formation of the IGF:IGFBP5:ALS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317216", "species_10317220", "species_10317208" ], "products": [ "species_10317222" ], "modifiers": [], "additional_components": [ "ENSXETG00000006623", "ENSXETT00000074759", "ENSXETT00000006287", "F7CZB7", "ENSXETT00000006287", "Q0IJ34", "ENSXETT00000074759", "A0A6I8PJ44", "ENSXETG00000006623" ] }, "reaction_10331191": { "compartment": "compartment_70101", "id": "reaction_10331191", "reactome": "R-XTR-5691512", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5691496", "species_29356" ], "products": [ "species_6785226", "species_5691517" ], "modifiers": [ [ "species_10331188", "catalyst" ] ], "additional_components": [ "species_5691517", "species_6785226", "ENSXETT00000050806" ] }, "reaction_10330583": { "compartment": "compartment_70101", "id": "reaction_10330583", "reactome": "R-XTR-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_5687529", "species_71285" ], "modifiers": [ [ "species_10330580", "catalyst" ] ], "additional_components": [ "ENSXETG00000017500" ] }, "reaction_10337612": { "compartment": "compartment_70101", "id": "reaction_10337612", "reactome": "R-XTR-9033232", "name": "PEX7 binds cargo proteins containing PTS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337604", "species_10337608" ], "products": [ "species_10337610" ], "modifiers": [], "additional_components": [ "ENSXETG00000027656", "ENSXETG00000008462", "A0A6I8R668", "ENSXETG00000008462", "A0A6I8SMH6", "ENSXETG00000027656" ] }, "reaction_10336877": { "compartment": "compartment_876", "id": "reaction_10336877", "reactome": "R-XTR-8951586", "name": "p-VAV family:PIP3 binds RAC1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325847", "species_10329285" ], "products": [ "species_10329291" ], "modifiers": [], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29420", "species_179838", "L7N3Q8", "ENSXETT00000043225", "species_179838", "L7N3Q8", "ENSXETT00000043225", "Q6GL60", "ENSXETT00000092508", "species_29420" ] }, "reaction_10329594": { "compartment": "compartment_876", "id": "reaction_10329594", "reactome": "R-XTR-5357445", "name": "PAK1-3 dimer disassociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329590" ], "products": [ "species_10329592" ], "modifiers": [], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "A0A6I8T271", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10329601": { "compartment": "compartment_876", "id": "reaction_10329601", "reactome": "R-XTR-5357472", "name": "PAK1-3 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10329592" ], "products": [ "species_29370", "species_10329598", "species_10329293" ], "modifiers": [ [ "species_10317378", "catalyst" ] ], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "A0A6I8T271", "ENSXETG00000011808", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10329603": { "compartment": "compartment_876", "id": "reaction_10329603", "reactome": "R-XTR-5357483", "name": "RAC1 binds PAK1-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317378", "species_10329293" ], "products": [ "species_10329590" ], "modifiers": [], "additional_components": [ "A0A6I8T271", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10329279": { "compartment": "compartment_70101", "id": "reaction_10329279", "reactome": "R-XTR-5218805", "name": "PKC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10329272" ], "products": [ "species_29370", "species_10329276" ], "modifiers": [ [ "species_10329272", "catalyst" ] ], "additional_components": [ "ENSXETG00000017294", "ENSXETG00000017294", "ENSXETG00000017294" ] }, "reaction_10329296": { "compartment": "compartment_876", "id": "reaction_10329296", "reactome": "R-XTR-5218850", "name": "VAV exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10329291" ], "products": [ "species_29420", "species_10329293" ], "modifiers": [ [ "species_10329291", "catalyst" ] ], "additional_components": [ "species_179838", "L7N3Q8", "ENSXETT00000043225", "Q6GL60", "ENSXETT00000092508", "species_29420", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "species_179838", "L7N3Q8", "ENSXETT00000043225", "Q6GL60", "ENSXETT00000092508", "species_29420" ] }, "reaction_10315879": { "compartment": "compartment_70101", "id": "reaction_10315879", "reactome": "R-XTR-202960", "name": "Caspase mediated cleavage of C-IAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315857" ], "products": [ "species_10315877", "species_10315867" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8QAZ5", "ENSXETG00000039278", "A0A6I8QAZ5", "ENSXETG00000039278", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8QAZ5", "ENSXETG00000039278", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10315839": { "compartment": "compartment_70101", "id": "reaction_10315839", "reactome": "R-XTR-202917", "name": "Caspase-mediated cleavage of Desmoglein 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315833" ], "products": [ "species_10315835", "species_10315837" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000034243", "ENSXETG00000034243", "ENSXETG00000034243", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10316731": { "compartment": "compartment_876", "id": "reaction_10316731", "reactome": "R-XTR-351913", "name": "Caspase-mediated cleavage of TJP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316727" ], "products": [ "species_10316729" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000020296", "ENSXETG00000020296", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10315674": { "compartment": "compartment_70101", "id": "reaction_10315674", "reactome": "R-XTR-201631", "name": "Caspase-mediated cleavage of Desmoglein 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315668" ], "products": [ "species_10315670", "species_10315672" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000034243", "ENSXETG00000034243", "ENSXETG00000034243", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10316723": { "compartment": "compartment_876", "id": "reaction_10316723", "reactome": "R-XTR-351877", "name": "Caspase-mediated cleavage of Desmoglein 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316719" ], "products": [ "species_10316721" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000034243", "ENSXETG00000034243", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10334778": { "compartment": "compartment_70101", "id": "reaction_10334778", "reactome": "R-XTR-8848726", "name": "PTK6 phosphorylates BCAR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334769", "species_113592" ], "products": [ "species_10334775", "species_10334679", "species_29370" ], "modifiers": [ [ "species_10334769", "catalyst" ] ], "additional_components": [ "L7N3R0", "ENSXETT00000043234", "A0A6I8Q2T5", "ENSXETG00000031017", "ENSXETT00000043234", "ENSXETG00000031017", "L7N3R0", "ENSXETT00000043234", "A0A6I8Q2T5", "ENSXETG00000031017" ] }, "reaction_10334771": { "compartment": "compartment_70101", "id": "reaction_10334771", "reactome": "R-XTR-8848713", "name": "PTK6 binds BCAR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334679", "species_10334767" ], "products": [ "species_10334769" ], "modifiers": [], "additional_components": [ "ENSXETG00000031017", "ENSXETT00000043234", "L7N3R0", "ENSXETT00000043234", "A0A6I8Q2T5", "ENSXETG00000031017" ] }, "reaction_10334782": { "compartment": "compartment_70101", "id": "reaction_10334782", "reactome": "R-XTR-8848930", "name": "PTK6 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334679" ], "products": [ "species_10334780" ], "modifiers": [], "additional_components": [ "ENSXETG00000031017", "ENSXETG00000031017" ] }, "reaction_10334792": { "compartment": "compartment_7660", "id": "reaction_10334792", "reactome": "R-XTR-8849032", "name": "PTK6 phosphorylates KHDRBS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334786", "species_29358" ], "products": [ "species_113582", "species_10334789" ], "modifiers": [ [ "species_10334780", "catalyst" ] ], "additional_components": [ "ENSXETG00000004451", "ENSXETG00000004451", "ENSXETG00000031017" ] }, "reaction_10334682": { "compartment": "compartment_70101", "id": "reaction_10334682", "reactome": "R-XTR-8848005", "name": "ERBB2 promotes PTK6 autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334674", "species_113592" ], "products": [ "species_10334679", "species_29370", "species_10322318" ], "modifiers": [ [ "species_10334674", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "A0A6I8Q2T5", "ENSXETG00000031017", "ENSXETG00000031017", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "A0A6I8Q2T5", "ENSXETG00000031017" ] }, "reaction_10334676": { "compartment": "compartment_876", "id": "reaction_10334676", "reactome": "R-XTR-8847995", "name": "Activated ERBB2 binds PTK6 (BRK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334672", "species_10322318" ], "products": [ "species_10334674" ], "modifiers": [], "additional_components": [ "ENSXETG00000031017", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "A0A6I8Q2T5", "ENSXETG00000031017" ] }, "reaction_10334802": { "compartment": "compartment_70101", "id": "reaction_10334802", "reactome": "R-XTR-8849102", "name": "SRMS phosphorylates PTK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334679", "species_113592" ], "products": [ "species_29370", "species_10334795" ], "modifiers": [ [ "species_10334799", "catalyst" ] ], "additional_components": [ "ENSXETG00000031017", "ENSXETG00000031017", "ENSXETG00000034490" ] }, "reaction_10318268": { "compartment": "compartment_876", "id": "reaction_10318268", "reactome": "R-XTR-442317", "name": "ZIP6 and ZIP14 mediate zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10318265", "catalyst" ] ], "additional_components": [ "ENSXETG00000010532" ] }, "reaction_10318288": { "compartment": "compartment_876", "id": "reaction_10318288", "reactome": "R-XTR-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10318285", "catalyst" ] ], "additional_components": [ "ENSXETG00000035832" ] }, "reaction_10337769": { "compartment": "compartment_70101", "id": "reaction_10337769", "reactome": "R-XTR-9614423", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316178", "species_10312804" ], "products": [ "species_10337767" ], "modifiers": [], "additional_components": [ "ENSXETT00000101788", "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830", "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830", "Q66JJ0", "ENSXETT00000101788" ] }, "reaction_10337765": { "compartment": "compartment_7660", "id": "reaction_10337765", "reactome": "R-XTR-9614414", "name": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315552" ], "products": [ "species_10316178" ], "modifiers": [], "additional_components": [ "ENSXETT00000101788", "ENSXETT00000101788" ] }, "reaction_10337071": { "compartment": "compartment_7660", "id": "reaction_10337071", "reactome": "R-XTR-8985343", "name": "RUNX2 binds SOX9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337067", "species_10335995" ], "products": [ "species_10337069" ], "modifiers": [], "additional_components": [ "ENSXETT00000087663", "ENSXETG00000001397", "Q6F2E7", "ENSXETT00000087663", "A0A6I8PZM7", "ENSXETG00000001397" ] }, "reaction_10336222": { "compartment": "compartment_7660", "id": "reaction_10336222", "reactome": "R-XTR-8938356", "name": "RMB14 binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336218", "species_10335995" ], "products": [ "species_10336220" ], "modifiers": [], "additional_components": [ "ENSXETG00000026650", "ENSXETG00000001397", "A0A6I8PZM7", "ENSXETG00000001397", "A0A6I8PSM7", "ENSXETG00000026650" ] }, "reaction_10336001": { "compartment": "compartment_7660", "id": "reaction_10336001", "reactome": "R-XTR-8877902", "name": "Activated AR binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335995", "species_10329949" ], "products": [ "species_10335999" ], "modifiers": [], "additional_components": [ "ENSXETG00000001397", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PZM7", "ENSXETG00000001397" ] }, "reaction_10317275": { "compartment": "compartment_7660", "id": "reaction_10317275", "reactome": "R-XTR-382096", "name": "Formation of NR-NCOR Corepressor Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317154", "species_10317271" ], "products": [ "species_10317273" ], "modifiers": [], "additional_components": [ "A4IIG7", "ENSXETT00000011580", "A0A6I8S377", "ENSXETT00000011580", "A0A6I8QVA7", "ENSXETG00000005219", "A0A6I8RH34", "ENSXETG00000031759", "F7EHW3", "ENSXETT00000025024", "F6SI83", "ENSXETT00000040897", "F6V3Y1", "ENSXETT00000012055", "A0A6I8S149", "ENSXETG00000040373", "F7C0K4", "ENSXETT00000050646", "A0A6I8QBV8", "ENSXETG00000021123", "Q28CK1", "ENSXETG00000023840", "A0A6I8QMK1", "ENSXETG00000007693", "F6WU58", "ENSXETT00000039111", "F7ETJ5", "ENSXETT00000028937", "F7BMW5", "ENSXETT00000027035", "Q66JK1", "ENSXETT00000090817", "A0A6I8RK73", "ENSXETG00000005089", "ENSXETG00000006720", "Q4KKX4", "ENSXETG00000006720", "A4IIG7", "ENSXETT00000011580", "A0A6I8S377", "ENSXETT00000011580", "A0A6I8QVA7", "ENSXETG00000005219", "A0A6I8RH34", "ENSXETG00000031759", "F7EHW3", "ENSXETT00000025024", "F6SI83", "ENSXETT00000040897", "F6V3Y1", "ENSXETT00000012055", "A0A6I8S149", "ENSXETG00000040373", "F7C0K4", "ENSXETT00000050646", "A0A6I8QBV8", "ENSXETG00000021123", "Q28CK1", "ENSXETG00000023840", "A0A6I8QMK1", "ENSXETG00000007693", "F6WU58", "ENSXETT00000039111", "F7ETJ5", "ENSXETT00000028937", "F7BMW5", "ENSXETT00000027035", "Q66JK1", "ENSXETT00000090817", "A0A6I8RK73", "ENSXETG00000005089" ] }, "reaction_10335895": { "compartment": "compartment_7660", "id": "reaction_10335895", "reactome": "R-XTR-8871260", "name": "YAP1 binds TEAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325861", "species_10325849" ], "products": [ "species_10335893" ], "modifiers": [], "additional_components": [ "ENSXETG00000036112", "ENSXETG00000032689", "A0A6I8SYU4", "ENSXETG00000032689", "A0A6I8SG09", "ENSXETG00000036112" ] }, "reaction_10325859": { "compartment": "compartment_7660", "id": "reaction_10325859", "reactome": "R-XTR-2032775", "name": "YAP1 binds TEAD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325849", "species_10325855" ], "products": [ "species_10325857" ], "modifiers": [], "additional_components": [ "ENSXETG00000032689", "ENSXETG00000036112", "A0A6I8SG09", "ENSXETG00000036112", "A0A6I8SYU4", "ENSXETG00000032689" ] }, "reaction_10326415": { "compartment": "compartment_70101", "id": "reaction_10326415", "reactome": "R-XTR-2187395", "name": "Dephosphorylated SMAD2/3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326413" ], "products": [ "species_10323441" ], "modifiers": [], "additional_components": [ "ENSXETT00000061335", "ENSXETT00000061335" ] }, "reaction_10337276": { "compartment": "compartment_876", "id": "reaction_10337276", "reactome": "R-XTR-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10325847" ], "products": [ "species_29420", "species_10312717" ], "modifiers": [ [ "species_10337273", "catalyst" ] ], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29420", "Q6GL60", "ENSXETT00000092508", "species_29438", "B1H2U7", "ENSXETT00000094272", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10337311": { "compartment": "compartment_876", "id": "reaction_10337311", "reactome": "R-XTR-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10312717" ], "products": [ "species_29372", "species_10325847" ], "modifiers": [ [ "species_10337308", "catalyst" ] ], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "Q6GL60", "ENSXETT00000092508", "species_29420", "Q08CX6", "ENSXETT00000056057", "A0A6I8SWA3", "ENSXETG00000032660", "A0A6I8SAF2", "ENSXETG00000004047", "F6UHQ8", "ENSXETT00000010378", "A0A6I8QAR5", "ENSXETG00000003287" ] }, "reaction_10337349": { "compartment": "compartment_876", "id": "reaction_10337349", "reactome": "R-XTR-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337345", "species_10325847" ], "products": [ "species_10337347" ], "modifiers": [], "additional_components": [ "ENSXETT00000020510", "Q6GL60", "ENSXETT00000092508", "species_29420", "F7D6Y2", "ENSXETT00000020510", "species_29420", "Q6GL60", "ENSXETT00000092508" ] }, "reaction_10338163": { "compartment": "compartment_876", "id": "reaction_10338163", "reactome": "R-XTR-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312717" ], "products": [ "species_10330027" ], "modifiers": [], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "Q6GL60", "ENSXETT00000092508", "species_29438" ] }, "reaction_10330269": { "compartment": "compartment_7660", "id": "reaction_10330269", "reactome": "R-XTR-5655193", "name": "KIAA0101 double monoubiquitination", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327687", "species_10330261" ], "products": [ "species_10330267" ], "modifiers": [], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "ENSXETT00000057278", "Q6AZL2", "ENSXETT00000057278", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858" ] }, "reaction_10312503": { "compartment": "compartment_7660", "id": "reaction_10312503", "reactome": "R-XTR-110322", "name": "Formation of Pol zeta complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312499", "species_10312495" ], "products": [ "species_10312501" ], "modifiers": [], "additional_components": [ "ENSXETT00000102467", "ENSXETG00000027754", "A0A6I8PTL2", "ENSXETG00000027754", "Q28H85", "ENSXETT00000102467" ] }, "reaction_10326699": { "compartment": "compartment_984", "id": "reaction_10326699", "reactome": "R-XTR-2395364", "name": "LTBP4 binds TGF-Beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326673", "species_10326683" ], "products": [ "species_10326697" ], "modifiers": [], "additional_components": [ "ENSXETG00000016967", "F6SX40", "ENSXETT00000046545", "F6SX40", "ENSXETT00000046545", "A0A6I8PY10", "ENSXETG00000016967" ] }, "reaction_10326695": { "compartment": "compartment_984", "id": "reaction_10326695", "reactome": "R-XTR-2395328", "name": "LTBP1, LTBP3 bind TGF-Beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326691", "species_10326685" ], "products": [ "species_10326693" ], "modifiers": [], "additional_components": [ "F6SX40", "ENSXETT00000046545", "A0A6I8RJM7", "ENSXETG00000019349", "A0A6I8S6N3", "ENSXETG00000008431", "A0A6I8RJM7", "ENSXETG00000019349", "A0A6I8S6N3", "ENSXETG00000008431", "F6SX40", "ENSXETT00000046545" ] }, "reaction_10327034": { "compartment": "compartment_876", "id": "reaction_10327034", "reactome": "R-XTR-2731078", "name": "Syndecans 2, (4) bind TGFB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313442", "species_10325703" ], "products": [ "species_10327032" ], "modifiers": [], "additional_components": [ "ENSXETT00000046545", "ENSXETG00000035467", "A0A6I8R5Q9", "ENSXETG00000035467", "F6SX40", "ENSXETT00000046545" ] }, "reaction_10326862": { "compartment": "compartment_984", "id": "reaction_10326862", "reactome": "R-XTR-2534248", "name": "DCN (decorin) degradation by MMP2, MMP3, MMP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326665" ], "products": [ "species_10326858", "species_10326860" ], "modifiers": [ [ "species_10323712", "catalyst" ] ], "additional_components": [ "ENSXETT00000063928", "ENSXETT00000063928", "ENSXETT00000063928", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801" ] }, "reaction_10323101": { "compartment": "compartment_984", "id": "reaction_10323101", "reactome": "R-XTR-1454757", "name": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323080" ], "products": [], "modifiers": [ [ "species_10323098", "catalyst" ] ], "additional_components": [ "Q6P4Z2", "ENSXETT00000043834", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8QL61", "ENSXETG00000022198", "A0A6I8RGF4", "ENSXETG00000002801", "F6ZRF9", "ENSXETT00000037915" ] }, "reaction_10323166": { "compartment": "compartment_984", "id": "reaction_10323166", "reactome": "R-XTR-1474197", "name": "Collagen type II degradation by MMP1,3,8,13,PRSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323151" ], "products": [ "species_10322559" ], "modifiers": [ [ "species_10323163", "catalyst" ] ], "additional_components": [ "Q6P4Z2", "ENSXETT00000043834", "Q6P4Z2", "ENSXETT00000043834", "A0A6I8QL61", "ENSXETG00000022198", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801" ] }, "reaction_10326201": { "compartment": "compartment_876", "id": "reaction_10326201", "reactome": "R-XTR-2167942", "name": "Collagen type XIII ectodomain shedding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326034" ], "products": [ "species_10326177", "species_10326175" ], "modifiers": [], "additional_components": [ "A0A6I8SFH9", "ENSXETG00000037705", "ENSXETG00000037705", "A0A6I8SFH9", "ENSXETG00000037705" ] }, "reaction_10326292": { "compartment": "compartment_984", "id": "reaction_10326292", "reactome": "R-XTR-2172433", "name": "Collagen type XIX degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326290" ], "products": [], "modifiers": [], "additional_components": [ "A0A6I8SFH9", "ENSXETG00000037705" ] }, "reaction_10323715": { "compartment": "compartment_984", "id": "reaction_10323715", "reactome": "R-XTR-1564142", "name": "Collagen type IV degradation by MMP2,3,4,9,10,12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323710" ], "products": [ "species_10323078" ], "modifiers": [ [ "species_10323712", "catalyst" ] ], "additional_components": [ "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801" ] }, "reaction_10323113": { "compartment": "compartment_984", "id": "reaction_10323113", "reactome": "R-XTR-1454781", "name": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323109", "species_10312984" ], "products": [ "species_10323111" ], "modifiers": [], "additional_components": [ "A0A6I8QL61", "ENSXETG00000022198", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801", "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942", "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942", "A0A6I8QL61", "ENSXETG00000022198", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801" ] }, "reaction_10334763": { "compartment": "compartment_70101", "id": "reaction_10334763", "reactome": "R-XTR-8848658", "name": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848706" ], "products": [ "species_8848709" ], "modifiers": [ [ "species_10334760", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "F7CZN1", "ENSXETT00000006277", "species_74112", "A0A6I8QL03", "ENSXETG00000030338" ] }, "reaction_10323839": { "compartment": "compartment_984", "id": "reaction_10323839", "reactome": "R-XTR-1602488", "name": "Initial activation of proMMP13 by plasmin and trypsin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323832" ], "products": [ "species_10323834", "species_10323836" ], "modifiers": [ [ "species_10323161", "catalyst" ] ], "additional_components": [ "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148" ] }, "reaction_10323881": { "compartment": "compartment_984", "id": "reaction_10323881", "reactome": "R-XTR-1604752", "name": "Initial activation of proMMP13 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323832" ], "products": [ "species_10323855", "species_10323868" ], "modifiers": [ [ "species_10323878", "catalyst" ] ], "additional_components": [ "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801", "F6ZRF9", "ENSXETT00000037915", "A0A6I8QK05", "ENSXETG00000027581", "A0A6I8SNY4", "ENSXETG00000035558" ] }, "reaction_10323864": { "compartment": "compartment_984", "id": "reaction_10323864", "reactome": "R-XTR-1604732", "name": "Autocatalytic activation of proMMP13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323853" ], "products": [ "species_10323857", "species_10323092" ], "modifiers": [ [ "species_10323853", "catalyst" ] ], "additional_components": [ "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801" ] }, "reaction_10323851": { "compartment": "compartment_984", "id": "reaction_10323851", "reactome": "R-XTR-1604731", "name": "Autocatalytic activation of MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323764" ], "products": [ "species_10323848", "species_10323096" ], "modifiers": [ [ "species_10323764", "catalyst" ] ], "additional_components": [ "ENSXETT00000037915", "ENSXETT00000037915", "ENSXETT00000037915", "ENSXETT00000037915" ] }, "reaction_10323781": { "compartment": "compartment_984", "id": "reaction_10323781", "reactome": "R-XTR-1592371", "name": "Initial activation of proMMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323762" ], "products": [ "species_10323766", "species_10323764" ], "modifiers": [ [ "species_10323778", "catalyst" ] ], "additional_components": [ "ENSXETT00000037915", "ENSXETT00000037915", "ENSXETT00000037915", "A0A6I8S6I3", "ENSXETG00000005867", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "A0A5G3K998", "ENSXETT00000090622" ] }, "reaction_10323735": { "compartment": "compartment_984", "id": "reaction_10323735", "reactome": "R-XTR-1592297", "name": "Full activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323732" ], "products": [ "species_10323084" ], "modifiers": [ [ "species_10323712", "catalyst" ] ], "additional_components": [ "ENSXETG00000022198", "ENSXETG00000022198", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801" ] }, "reaction_10323830": { "compartment": "compartment_984", "id": "reaction_10323830", "reactome": "R-XTR-1602473", "name": "Autocatalytic activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323739" ], "products": [ "species_10323827", "species_10323732" ], "modifiers": [ [ "species_10323739", "catalyst" ] ], "additional_components": [ "ENSXETG00000022198", "ENSXETG00000022198", "ENSXETG00000022198", "ENSXETG00000022198" ] }, "reaction_10323846": { "compartment": "compartment_984", "id": "reaction_10323846", "reactome": "R-XTR-1604359", "name": "Initial activation of proMMP2 by MMP1, 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323841" ], "products": [ "species_10323843", "species_10323725" ], "modifiers": [ [ "species_10323084", "catalyst" ] ], "additional_components": [ "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000022198" ] }, "reaction_10323825": { "compartment": "compartment_984", "id": "reaction_10323825", "reactome": "R-XTR-1602458", "name": "Activation of proMMP10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323820" ], "products": [ "species_10323103" ], "modifiers": [ [ "species_10323822", "catalyst" ] ], "additional_components": [ "ENSXETT00000037915", "ENSXETT00000037915", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "A0A5G3K998", "ENSXETT00000090622" ] }, "reaction_10323760": { "compartment": "compartment_984", "id": "reaction_10323760", "reactome": "R-XTR-1592316", "name": "Initial activation of proMMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323737" ], "products": [ "species_10323739", "species_10323741" ], "modifiers": [ [ "species_10323757", "catalyst" ] ], "additional_components": [ "ENSXETG00000022198", "ENSXETG00000022198", "ENSXETG00000022198", "A0A6I8S6I3", "ENSXETG00000005867", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "A0A6I8RBC3", "ENSXETG00000037351", "Q5HZU5", "ENSXETT00000093455", "A0A6I8QPJ5", "ENSXETG00000039590", "F7EHU5", "ENSXETT00000037000" ] }, "reaction_10323730": { "compartment": "compartment_984", "id": "reaction_10323730", "reactome": "R-XTR-1592278", "name": "Autocatalytic activation of proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323725" ], "products": [ "species_10323094", "species_10323727" ], "modifiers": [ [ "species_10323725", "catalyst" ] ], "additional_components": [ "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801" ] }, "reaction_10324621": { "compartment": "compartment_12045", "id": "reaction_10324621", "reactome": "R-XTR-1981104", "name": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10324614", "species_1650779" ], "products": [ "species_1650769", "species_10324618", "species_159751" ], "modifiers": [ [ "species_10324612", "catalyst" ] ], "additional_components": [ "species_435347", "F7D3M1", "ENSXETT00000023809", "species_435347", "F7D3M1", "ENSXETT00000023809", "species_435347", "F7D3M1", "ENSXETT00000023809" ] }, "reaction_10336797": { "compartment": "compartment_17957", "id": "reaction_10336797", "reactome": "R-XTR-8944250", "name": "Association of procollagen type XXV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325361" ], "products": [ "species_10325363" ], "modifiers": [], "additional_components": [ "ENSXETG00000035357", "A0A6I8STN5", "ENSXETG00000035357" ] }, "reaction_10336799": { "compartment": "compartment_17957", "id": "reaction_10336799", "reactome": "R-XTR-8944254", "name": "Association of procollagen type XXVI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325368" ], "products": [ "species_10325392" ], "modifiers": [], "additional_components": [ "ENSXETG00000035357", "A0A6I8STN5", "ENSXETG00000035357" ] }, "reaction_10336793": { "compartment": "compartment_17957", "id": "reaction_10336793", "reactome": "R-XTR-8944242", "name": "Association of procollagen type XXVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325394" ], "products": [ "species_10325418" ], "modifiers": [], "additional_components": [ "ENSXETT00000032928", "A0JP88", "ENSXETT00000032928" ] }, "reaction_10336795": { "compartment": "compartment_17957", "id": "reaction_10336795", "reactome": "R-XTR-8944246", "name": "Association of procollagen type XXI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325329" ], "products": [ "species_10325331" ], "modifiers": [], "additional_components": [ "ENSXETG00000034204", "A0A6I8RDS2", "ENSXETG00000034204" ] }, "reaction_10336805": { "compartment": "compartment_17957", "id": "reaction_10336805", "reactome": "R-XTR-8944265", "name": "Association of procollagen type IV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325154", "species_10325056", "species_10325206", "species_10325156", "species_10325182", "species_10325054" ], "products": [ "species_10325232" ], "modifiers": [], "additional_components": [ "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "ENSXETG00000001547", "ENSXETG00000001547", "ENSXETG00000001547", "ENSXETG00000001565", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565" ] }, "reaction_10336791": { "compartment": "compartment_17957", "id": "reaction_10336791", "reactome": "R-XTR-8944236", "name": "Association of procollagen type XIV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325272" ], "products": [ "species_10325298" ], "modifiers": [], "additional_components": [ "ENSXETG00000005761", "A0A6I8RGK2", "ENSXETG00000005761" ] }, "reaction_10336801": { "compartment": "compartment_17957", "id": "reaction_10336801", "reactome": "R-XTR-8944261", "name": "Association of procollagen type XIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325239" ], "products": [ "species_10325265" ], "modifiers": [], "additional_components": [ "ENSXETG00000037705", "A0A6I8SFH9", "ENSXETG00000037705" ] }, "reaction_10324656": { "compartment": "compartment_17957", "id": "reaction_10324656", "reactome": "R-XTR-2002401", "name": "Association of procollagen type XVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324628" ], "products": [ "species_10324654" ], "modifiers": [], "additional_components": [ "ENSXETT00000012721", "F6VQW0", "ENSXETT00000012721" ] }, "reaction_10336803": { "compartment": "compartment_17957", "id": "reaction_10336803", "reactome": "R-XTR-8944263", "name": "Association of procollagen type II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324956" ], "products": [ "species_10324980" ], "modifiers": [], "additional_components": [ "ENSXETT00000043834", "Q6P4Z2", "ENSXETT00000043834" ] }, "reaction_10336787": { "compartment": "compartment_17957", "id": "reaction_10336787", "reactome": "R-XTR-8944227", "name": "Association of procollagen type XXII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325336" ], "products": [ "species_10325357" ], "modifiers": [], "additional_components": [ "ENSXETG00000034204", "A0A6I8RDS2", "ENSXETG00000034204" ] }, "reaction_10326042": { "compartment": "compartment_17957", "id": "reaction_10326042", "reactome": "R-XTR-2152276", "name": "Secretion of transmembrane collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326008" ], "products": [ "species_10326040" ], "modifiers": [], "additional_components": [ "A0A6I8SFH9", "ENSXETG00000037705", "A0A6I8STN5", "ENSXETG00000035357", "A0A6I8STN5", "ENSXETG00000035357", "A0A6I8SFH9", "ENSXETG00000037705" ] }, "reaction_10326479": { "compartment": "compartment_984", "id": "reaction_10326479", "reactome": "R-XTR-2213207", "name": "Formation of collagen networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326477" ], "products": [ "species_10323710" ], "modifiers": [], "additional_components": [ "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547" ] }, "reaction_10326447": { "compartment": "compartment_984", "id": "reaction_10326447", "reactome": "R-XTR-2213201", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323205" ], "products": [ "species_10326445" ], "modifiers": [], "additional_components": [ "Q6P4Z2", "ENSXETT00000043834", "A0JP88", "ENSXETT00000032928", "Q6P4Z2", "ENSXETT00000043834", "A0JP88", "ENSXETT00000032928" ] }, "reaction_10326993": { "compartment": "compartment_984", "id": "reaction_10326993", "reactome": "R-XTR-2559639", "name": "Collagen type IV sulfilimine cross-linking by peroxidasin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_10323710" ], "products": [ "species_10326984" ], "modifiers": [ [ "species_10326990", "catalyst" ] ], "additional_components": [ "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8R6H3", "ENSXETG00000002635", "A4IGL7", "ENSXETG00000006965", "CHEBI:15858" ] }, "reaction_10323207": { "compartment": "compartment_984", "id": "reaction_10323207", "reactome": "R-XTR-1474266", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323201" ], "products": [ "species_10323205" ], "modifiers": [], "additional_components": [ "Q6P4Z2", "ENSXETT00000043834", "A0JP88", "ENSXETT00000032928", "Q6P4Z2", "ENSXETT00000043834", "A0JP88", "ENSXETT00000032928" ] }, "reaction_10326814": { "compartment": "compartment_984", "id": "reaction_10326814", "reactome": "R-XTR-2426450", "name": "Laminins:Nidogens binds collagen type IV networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326810", "species_10323710" ], "products": [ "species_10326812" ], "modifiers": [], "additional_components": [ "A0A6I8QYL3", "ENSXETG00000012279", "A0A6I8SMI4", "ENSXETG00000007336", "A0JP86", "ENSXETG00000012525", "A0A6I8RIS5", "ENSXETG00000012198", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8QYL3", "ENSXETG00000012279", "A0A6I8SMI4", "ENSXETG00000007336", "A0JP86", "ENSXETG00000012525", "A0A6I8RIS5", "ENSXETG00000012198" ] }, "reaction_10336708": { "compartment": "compartment_876", "id": "reaction_10336708", "reactome": "R-XTR-8941234", "name": "SH3PXD2A binds ADAM12,ADAM15,ADAM19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336704", "species_10336700" ], "products": [ "species_10336706" ], "modifiers": [], "additional_components": [ "ENSXETG00000034170", "species_1806238", "A0A6I8RHF6", "ENSXETG00000011399", "species_1806238", "A0A6I8RHF6", "ENSXETG00000011399", "A0A6I8PWV8", "ENSXETG00000034170" ] }, "reaction_10323437": { "compartment": "compartment_70101", "id": "reaction_10323437", "reactome": "R-XTR-1504213", "name": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323415", "species_10323417" ], "products": [ "species_10323419" ], "modifiers": [], "additional_components": [ "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8SYH3", "ENSXETG00000025907", "A4IHP4", "ENSXETT00000017945", "B1WAP7", "ENSXETT00000037606", "Q05AS8", "ENSXETG00000017212", "B1WAP7", "ENSXETT00000037606", "Q05AS8", "ENSXETG00000017212", "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8SYH3", "ENSXETG00000025907", "A4IHP4", "ENSXETT00000017945" ] }, "reaction_10323435": { "compartment": "compartment_70101", "id": "reaction_10323435", "reactome": "R-XTR-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312116", "species_10323419" ], "products": [ "species_10323432" ], "modifiers": [ [ "species_10323419", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "B1WAP7", "ENSXETT00000037606", "Q05AS8", "ENSXETG00000017212", "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8SYH3", "ENSXETG00000025907", "A4IHP4", "ENSXETT00000017945", "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8SYH3", "ENSXETG00000025907", "A4IHP4", "ENSXETT00000017945", "Q05AS8", "ENSXETG00000017212", "B1WAP7", "ENSXETT00000037606", "B1WAP7", "ENSXETT00000037606", "Q05AS8", "ENSXETG00000017212", "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8SYH3", "ENSXETG00000025907", "A4IHP4", "ENSXETT00000017945" ] }, "reaction_10328747": { "compartment": "compartment_70101", "id": "reaction_10328747", "reactome": "R-XTR-4641147", "name": "DACT1 binds DVL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328743", "species_10315690" ], "products": [ "species_10328745" ], "modifiers": [], "additional_components": [ "ENSXETG00000011962", "ENSXETG00000017212", "Q05AS8", "ENSXETG00000017212", "Q66KC9", "ENSXETG00000011962" ] }, "reaction_10328777": { "compartment": "compartment_876", "id": "reaction_10328777", "reactome": "R-XTR-4641246", "name": "ZNRF3 autoubiquitinates to promote its internalization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312116", "species_10328767" ], "products": [ "species_10328774" ], "modifiers": [ [ "species_10328767", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q08D68", "ENSXETT00000070371", "Q5M7L6", "ENSXETT00000065307", "A0A6I8PSP2", "ENSXETG00000030823", "Q08D68", "ENSXETT00000070371", "Q5M7L6", "ENSXETT00000065307", "A0A6I8PSP2", "ENSXETG00000030823", "Q08D68", "ENSXETT00000070371", "Q5M7L6", "ENSXETT00000065307", "A0A6I8PSP2", "ENSXETG00000030823" ] }, "reaction_10328795": { "compartment": "compartment_876", "id": "reaction_10328795", "reactome": "R-XTR-4641253", "name": "ZNRF3 ubiquitinates FZD to promote its downregulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328787", "species_10312116" ], "products": [ "species_10328792" ], "modifiers": [ [ "species_10328787", "catalyst" ] ], "additional_components": [ "Q08D68", "ENSXETT00000070371", "A0A6I8QRN7", "ENSXETG00000034910", "A0A6I8S584", "ENSXETG00000008917", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q08D68", "ENSXETT00000070371", "A0A6I8QRN7", "ENSXETG00000034910", "A0A6I8S584", "ENSXETG00000008917", "Q08D68", "ENSXETT00000070371", "A0A6I8QRN7", "ENSXETG00000034910", "A0A6I8S584", "ENSXETG00000008917" ] }, "reaction_10328769": { "compartment": "compartment_876", "id": "reaction_10328769", "reactome": "R-XTR-4641205", "name": "RSPO:LGR binds ZNRF3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328761", "species_10328765" ], "products": [ "species_10328767" ], "modifiers": [], "additional_components": [ "Q5M7L6", "ENSXETT00000065307", "A0A6I8PSP2", "ENSXETG00000030823", "ENSXETT00000070371", "Q08D68", "ENSXETT00000070371", "Q5M7L6", "ENSXETT00000065307", "A0A6I8PSP2", "ENSXETG00000030823" ] }, "reaction_10335855": { "compartment": "compartment_12045", "id": "reaction_10335855", "reactome": "R-XTR-8869206", "name": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8869214" ], "products": [ "species_29416", "species_8869207" ], "modifiers": [ [ "species_10335852", "catalyst" ] ], "additional_components": [ "ENSXETG00000040379" ] }, "reaction_10317819": { "compartment": "compartment_984", "id": "reaction_10317819", "reactome": "R-XTR-419490", "name": "Binding of ATP to P2X receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114570", "species_10312780" ], "products": [ "species_10312782" ], "modifiers": [], "additional_components": [ "ENSXETG00000041261", "A0A6I8S619", "ENSXETG00000041261", "species_113593" ] }, "reaction_10312785": { "compartment": "compartment_876", "id": "reaction_10312785", "reactome": "R-XTR-139855", "name": "P2X1-mediated entry of Ca++ from plasma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10312782", "catalyst" ] ], "additional_components": [ "A0A6I8S619", "ENSXETG00000041261", "species_113593" ] }, "reaction_10317725": { "compartment": "compartment_114521", "id": "reaction_10317725", "reactome": "R-XTR-418365", "name": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427899", "species_74016" ], "products": [ "species_70106", "species_139827" ], "modifiers": [ [ "species_10317722", "catalyst" ] ], "additional_components": [ "A0A6I8Q1N1", "ENSXETG00000002512", "A0A6I8RIR9", "ENSXETG00000009695" ] }, "reaction_10317712": { "compartment": "compartment_876", "id": "reaction_10317712", "reactome": "R-XTR-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10317709", "catalyst" ] ], "additional_components": [ "ENSXETG00000000441" ] }, "reaction_10328380": { "compartment": "compartment_70101", "id": "reaction_10328380", "reactome": "R-XTR-3928578", "name": "EPH receptors autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10328363" ], "products": [ "species_29370", "species_10328377" ], "modifiers": [ [ "species_10328363", "catalyst" ] ], "additional_components": [ "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R4R5", "ENSXETG00000017584", "A0A6I8R3N5", "ENSXETG00000018746", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584" ] }, "reaction_10328388": { "compartment": "compartment_876", "id": "reaction_10328388", "reactome": "R-XTR-3928646", "name": "EPHAs bind EFNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328359", "species_10328349" ], "products": [ "species_10328361" ], "modifiers": [], "additional_components": [ "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584" ] }, "reaction_10328519": { "compartment": "compartment_876", "id": "reaction_10328519", "reactome": "R-XTR-4093342", "name": "SDC2 multimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328515" ], "products": [ "species_10328517" ], "modifiers": [], "additional_components": [ "ENSXETG00000035467", "A0A6I8R5Q9", "ENSXETG00000035467" ] }, "reaction_10328384": { "compartment": "compartment_876", "id": "reaction_10328384", "reactome": "R-XTR-3928591", "name": "EPH:EFN tetramers oligomerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328361", "species_10328382" ], "products": [ "species_10328363" ], "modifiers": [], "additional_components": [ "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584" ] }, "reaction_10328386": { "compartment": "compartment_876", "id": "reaction_10328386", "reactome": "R-XTR-3928597", "name": "EPH:EFN dimers tetramerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328361" ], "products": [ "species_10328382" ], "modifiers": [], "additional_components": [ "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584" ] }, "reaction_10313950": { "compartment": "compartment_70101", "id": "reaction_10313950", "reactome": "R-XTR-183036", "name": "Ubiquitination of stimulated EGFR (CBL:GRB2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312116", "species_10313941" ], "products": [ "species_10313947" ], "modifiers": [ [ "species_10313941", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "Q66II3", "ENSXETT00000027387", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "Q66II3", "ENSXETT00000027387", "F7C8B9", "ENSXETT00000006761", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "Q66II3", "ENSXETT00000027387", "F7C8B9", "ENSXETT00000006761" ] }, "reaction_10313975": { "compartment": "compartment_70101", "id": "reaction_10313975", "reactome": "R-XTR-183058", "name": "Phosphorylation of CBL (EGFR:GRB2:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10313972" ], "products": [ "species_29370", "species_10313941" ], "modifiers": [ [ "species_10313972", "catalyst" ] ], "additional_components": [ "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "Q66II3", "ENSXETT00000027387", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10313968": { "compartment": "compartment_70101", "id": "reaction_10313968", "reactome": "R-XTR-183051", "name": "CBL ubiquitinates Sprouty", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312116", "species_10313961" ], "products": [ "species_10313965" ], "modifiers": [ [ "species_10313961", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8SCT0", "ENSXETG00000041240", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8SCT0", "ENSXETG00000041240", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8SCT0", "ENSXETG00000041240" ] }, "reaction_10313903": { "compartment": "compartment_70101", "id": "reaction_10313903", "reactome": "R-XTR-177934", "name": "EGFR autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313842", "species_113592" ], "products": [ "species_29370", "species_10313869" ], "modifiers": [ [ "species_10313842", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877" ] }, "reaction_10313900": { "compartment": "compartment_70101", "id": "reaction_10313900", "reactome": "R-XTR-177930", "name": "GAB1 phosphorylation by EGFR kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10313892" ], "products": [ "species_29370", "species_10313871" ], "modifiers": [ [ "species_10313892", "catalyst" ] ], "additional_components": [ "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838" ] }, "reaction_10313886": { "compartment": "compartment_70101", "id": "reaction_10313886", "reactome": "R-XTR-177924", "name": "Dephosphorylation of Gab1 by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10313873" ], "products": [ "species_29372", "species_10313883" ], "modifiers": [ [ "species_10313873", "catalyst" ] ], "additional_components": [ "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838" ] }, "reaction_10313913": { "compartment": "compartment_70101", "id": "reaction_10313913", "reactome": "R-XTR-177935", "name": "SHP2 dephosphorylates Tyr 992 on EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10313873" ], "products": [ "species_29372", "species_10313911" ], "modifiers": [ [ "species_10313873", "catalyst" ] ], "additional_components": [ "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838" ] }, "reaction_10313816": { "compartment": "compartment_70101", "id": "reaction_10313816", "reactome": "R-XTR-177920", "name": "Binding of GRB2 to GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313812", "species_10312043" ], "products": [ "species_10313814" ], "modifiers": [], "additional_components": [ "ENSXETT00000038110", "ENSXETT00000027387", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110" ] }, "reaction_10313924": { "compartment": "compartment_70101", "id": "reaction_10313924", "reactome": "R-XTR-177941", "name": "GRB2:GAB1 binds to phosphorylated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313890", "species_10313869" ], "products": [ "species_10313892" ], "modifiers": [], "additional_components": [ "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838" ] }, "reaction_10313937": { "compartment": "compartment_70101", "id": "reaction_10313937", "reactome": "R-XTR-179467", "name": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10313814" ], "products": [ "species_10313888" ], "modifiers": [], "additional_components": [ "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838" ] }, "reaction_10313922": { "compartment": "compartment_70101", "id": "reaction_10313922", "reactome": "R-XTR-177939", "name": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10313919", "catalyst" ] ], "additional_components": [ "A0A6I8RUB1", "ENSXETG00000007252", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838" ] }, "reaction_10313930": { "compartment": "compartment_984", "id": "reaction_10313930", "reactome": "R-XTR-177942", "name": "EGFR binds EGF ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313838", "species_10313820" ], "products": [ "species_10313840" ], "modifiers": [ [ "species_10313928", "inhibitor" ] ], "additional_components": [ "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "ENSXETT00000006761", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "ENSXETT00000017426" ] }, "reaction_10313844": { "compartment": "compartment_876", "id": "reaction_10313844", "reactome": "R-XTR-177922", "name": "EGFR dimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313840" ], "products": [ "species_10313842" ], "modifiers": [], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877" ] }, "reaction_10313935": { "compartment": "compartment_70101", "id": "reaction_10313935", "reactome": "R-XTR-177943", "name": "GRB2:SOS1 complex binds to EGF:EGFR complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312049", "species_10313869" ], "products": [ "species_10313933" ], "modifiers": [], "additional_components": [ "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10312326": { "compartment": "compartment_70101", "id": "reaction_10312326", "reactome": "R-XTR-109813", "name": "GRB2-1 binds SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312043", "species_10312047" ], "products": [ "species_10312049" ], "modifiers": [], "additional_components": [ "ENSXETT00000027387", "ENSXETT00000044021", "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10314255": { "compartment": "compartment_984", "id": "reaction_10314255", "reactome": "R-XTR-192475", "name": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10314252", "catalyst" ] ], "additional_components": [ "F6ZWX1", "ENSXETT00000007508" ] }, "reaction_10337016": { "compartment": "compartment_984", "id": "reaction_10337016", "reactome": "R-XTR-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10337013", "catalyst" ] ], "additional_components": [] }, "reaction_10314244": { "compartment": "compartment_984", "id": "reaction_10314244", "reactome": "R-XTR-192434", "name": "Digestion of diacylglycerols by extracellular PTL:colipase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_174675" ], "products": [ "species_6814795", "species_174602" ], "modifiers": [ [ "species_10314239", "catalyst" ] ], "additional_components": [ "F6ZWX1", "ENSXETT00000007508" ] }, "reaction_10314242": { "compartment": "compartment_984", "id": "reaction_10314242", "reactome": "R-XTR-192422", "name": "Digestion of triacylglycerols by extracellular PTL:colipase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10314239", "catalyst" ] ], "additional_components": [ "F6ZWX1", "ENSXETT00000007508" ] }, "reaction_10329311": { "compartment": "compartment_7660", "id": "reaction_10329311", "reactome": "R-XTR-5218952", "name": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10327320" ], "products": [ "species_77502", "species_10329304" ], "modifiers": [ [ "species_10329308", "catalyst" ] ], "additional_components": [ "ENSXETG00000006676" ] }, "reaction_10329214": { "compartment": "compartment_7660", "id": "reaction_10329214", "reactome": "R-XTR-5205867", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10329171" ], "products": [ "species_77502", "species_10329211" ], "modifiers": [ [ "species_10327331", "catalyst" ] ], "additional_components": [ "ENSXETT00000094658" ] }, "reaction_10329098": { "compartment": "compartment_7660", "id": "reaction_10329098", "reactome": "R-XTR-5205820", "name": "PRMT6 methylates arginine-4 of histone H2A (H2AR3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10329055" ], "products": [ "species_77502", "species_10329095" ], "modifiers": [ [ "species_10329010", "catalyst" ] ], "additional_components": [ "ENSXETG00000009939" ] }, "reaction_10329429": { "compartment": "compartment_7660", "id": "reaction_10329429", "reactome": "R-XTR-5229203", "name": "PRMT6 methylates histone H2A arginine-30 (H2AR29)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10329387" ], "products": [ "species_77502", "species_10329427" ], "modifiers": [ [ "species_10329010", "catalyst" ] ], "additional_components": [ "ENSXETG00000009939" ] }, "reaction_10329124": { "compartment": "compartment_7660", "id": "reaction_10329124", "reactome": "R-XTR-5205824", "name": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10329112" ], "products": [ "species_77502", "species_10329122" ], "modifiers": [ [ "species_10329010", "catalyst" ] ], "additional_components": [ "ENSXETG00000009939" ] }, "reaction_10329015": { "compartment": "compartment_7660", "id": "reaction_10329015", "reactome": "R-XTR-5205798", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313794", "species_77087" ], "products": [ "species_77502", "species_10329006" ], "modifiers": [ [ "species_10329012", "catalyst" ] ], "additional_components": [ "ENSXETG00000035354", "ENSXETG00000035354", "Q28F07", "ENSXETT00000094658", "B0JYW5", "ENSXETG00000009939" ] }, "reaction_10330343": { "compartment": "compartment_7660", "id": "reaction_10330343", "reactome": "R-XTR-5661126", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10329006" ], "products": [ "species_77502", "species_10330341" ], "modifiers": [ [ "species_10329012", "catalyst" ] ], "additional_components": [ "ENSXETG00000035354", "ENSXETG00000035354", "Q28F07", "ENSXETT00000094658", "B0JYW5", "ENSXETG00000009939" ] }, "reaction_10329334": { "compartment": "compartment_7660", "id": "reaction_10329334", "reactome": "R-XTR-5225649", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316471", "species_10327320" ], "products": [ "species_10329332" ], "modifiers": [ [ "species_10329304", "inhibitor" ] ], "additional_components": [ "ENSXETT00000002157", "Q6P315", "ENSXETT00000002157" ] }, "reaction_10329330": { "compartment": "compartment_7660", "id": "reaction_10329330", "reactome": "R-XTR-5225602", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329304", "species_10329326" ], "products": [ "species_10329328" ], "modifiers": [], "additional_components": [ "ENSXETT00000102075", "Q5M786", "ENSXETT00000102075" ] }, "reaction_10326338": { "compartment": "compartment_70101", "id": "reaction_10326338", "reactome": "R-XTR-2176452", "name": "Degradation of ubiquitinated SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326336" ], "products": [], "modifiers": [], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q07G47", "ENSXETT00000061335" ] }, "reaction_10337420": { "compartment": "compartment_876", "id": "reaction_10337420", "reactome": "R-XTR-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337392", "species_10337416" ], "products": [ "species_10337418" ], "modifiers": [], "additional_components": [ "B1H300", "ENSXETT00000065865", "species_29438", "A0A6I8SQB3", "ENSXETG00000005314", "A0A6I8SBQ3", "ENSXETG00000021139", "A0A6I8T271", "ENSXETG00000011808", "A0A6I8SQB3", "ENSXETG00000005314", "A0A6I8SBQ3", "ENSXETG00000021139", "A0A6I8T271", "ENSXETG00000011808", "B1H300", "ENSXETT00000065865", "species_29438" ] }, "reaction_10337396": { "compartment": "compartment_876", "id": "reaction_10337396", "reactome": "R-XTR-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337392", "species_10337345" ], "products": [ "species_10337394" ], "modifiers": [], "additional_components": [ "B1H300", "ENSXETT00000065865", "species_29438", "ENSXETT00000020510", "F7D6Y2", "ENSXETT00000020510", "B1H300", "ENSXETT00000065865", "species_29438" ] }, "reaction_10337398": { "compartment": "compartment_876", "id": "reaction_10337398", "reactome": "R-XTR-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10337390" ], "products": [ "species_10337392" ], "modifiers": [], "additional_components": [ "ENSXETT00000065865", "B1H300", "ENSXETT00000065865", "species_29438" ] }, "reaction_10319096": { "compartment": "compartment_20699", "id": "reaction_10319096", "reactome": "R-XTR-744230", "name": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_744239" ], "products": [ "species_113578", "species_744233" ], "modifiers": [ [ "species_10319093", "catalyst" ] ], "additional_components": [ "ENSXETG00000041312" ] }, "reaction_10312321": { "compartment": "compartment_70101", "id": "reaction_10312321", "reactome": "R-XTR-109538", "name": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737", "species_74113" ], "products": [ "species_179743", "species_83910" ], "modifiers": [ [ "species_10312318", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_8857850", "CHEBI:17562", "species_8857850", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "ENSXETG00000011724" ] }, "reaction_10329473": { "compartment": "compartment_5460", "id": "reaction_10329473", "reactome": "R-XTR-5250210", "name": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329471" ], "products": [ "species_10329463" ], "modifiers": [], "additional_components": [ "Q5FW25", "ENSXETT00000039869", "F7BJL3", "ENSXETT00000003496", "species_29438", "Q5FW25", "ENSXETT00000039869", "F7BJL3", "ENSXETT00000003496", "species_29438" ] }, "reaction_10329475": { "compartment": "compartment_70101", "id": "reaction_10329475", "reactome": "R-XTR-5250217", "name": "ARL2:GTP binds ARL2BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329467", "species_10329469" ], "products": [ "species_10329471" ], "modifiers": [], "additional_components": [ "F7BJL3", "ENSXETT00000003496", "species_29438", "ENSXETT00000039869", "Q5FW25", "ENSXETT00000039869", "F7BJL3", "ENSXETT00000003496", "species_29438" ] }, "reaction_10316666": { "compartment": "compartment_984", "id": "reaction_10316666", "reactome": "R-XTR-349657", "name": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316664", "species_171095", "species_171142" ], "products": [ "species_10316576" ], "modifiers": [], "additional_components": [ "A0A6I8PU04", "ENSXETG00000033423", "species_163579", "species_171142", "species_216762", "A0A6I8PU04", "ENSXETG00000033423", "species_171142", "species_216762" ] }, "reaction_10316578": { "compartment": "compartment_984", "id": "reaction_10316578", "reactome": "R-XTR-216756", "name": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171095", "species_171142", "species_10313516" ], "products": [ "species_10316576" ], "modifiers": [], "additional_components": [ "ENSXETG00000033423", "A0A6I8PU04", "ENSXETG00000033423", "species_171142", "species_216762" ] }, "reaction_10312324": { "compartment": "compartment_70101", "id": "reaction_10312324", "reactome": "R-XTR-109699", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10312070", "catalyst" ] ], "additional_components": [ "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252", "A0A6I8RAF1", "ENSXETG00000039550" ] }, "reaction_10312072": { "compartment": "compartment_70101", "id": "reaction_10312072", "reactome": "R-XTR-74737", "name": "p-Y-IRS1,p-Y-IRS2 bind PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312054", "species_10312068" ], "products": [ "species_10312070" ], "modifiers": [], "additional_components": [ "ENSXETG00000039550", "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252", "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252", "A0A6I8RAF1", "ENSXETG00000039550" ] }, "reaction_10312058": { "compartment": "compartment_70101", "id": "reaction_10312058", "reactome": "R-XTR-74736", "name": "GRB2-1:SOS1 binds p-IRS1,p-IRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312049", "species_10312054" ], "products": [ "species_10312056" ], "modifiers": [], "additional_components": [ "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387", "ENSXETG00000039550", "A0A6I8RAF1", "ENSXETG00000039550", "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10316221": { "compartment": "compartment_7660", "id": "reaction_10316221", "reactome": "R-XTR-211207", "name": "Cleaved fragments of DFF45 dissociate from DFF40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316198" ], "products": [ "species_10316194", "species_10316196", "species_10316184", "species_10316188" ], "modifiers": [], "additional_components": [ "F6TTW7", "ENSXETT00000013820", "F7EHJ0", "ENSXETT00000013293", "ENSXETT00000013820", "ENSXETT00000013820", "ENSXETT00000013293", "ENSXETT00000013820" ] }, "reaction_10316223": { "compartment": "compartment_13231", "id": "reaction_10316223", "reactome": "R-XTR-211219", "name": "Translocation of caspase-3 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312650" ], "products": [ "species_10316206" ], "modifiers": [], "additional_components": [ "A0A6I8PZK4", "ENSXETG00000030678", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10316219": { "compartment": "compartment_7660", "id": "reaction_10316219", "reactome": "R-XTR-211193", "name": "Homodimerization of DFF40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316184" ], "products": [ "species_10316217" ], "modifiers": [], "additional_components": [ "ENSXETT00000013293", "F7EHJ0", "ENSXETT00000013293" ] }, "reaction_10316346": { "compartment": "compartment_7660", "id": "reaction_10316346", "reactome": "R-XTR-211247", "name": "Cleavage of DNA by DFF40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316339" ], "products": [ "species_10316337", "species_10316343" ], "modifiers": [ [ "species_10316339", "catalyst" ] ], "additional_components": [ "Q6NVM0", "ENSXETT00000101169", "F7EHJ0", "ENSXETT00000013293", "F7EHJ0", "ENSXETT00000013293", "Q6NVM0", "ENSXETT00000101169", "Q6NVM0", "ENSXETT00000101169", "F7EHJ0", "ENSXETT00000013293" ] }, "reaction_10316341": { "compartment": "compartment_7660", "id": "reaction_10316341", "reactome": "R-XTR-211239", "name": "Association of DFF40 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316337", "species_10316333" ], "products": [ "species_10316339" ], "modifiers": [], "additional_components": [ "F7EHJ0", "ENSXETT00000013293", "Q6NVM0", "ENSXETT00000101169", "Q6NVM0", "ENSXETT00000101169", "F7EHJ0", "ENSXETT00000013293" ] }, "reaction_10316231": { "compartment": "compartment_70101", "id": "reaction_10316231", "reactome": "R-XTR-211224", "name": "Association of DFF40 with DFF45", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316227", "species_10316225" ], "products": [ "species_10316229" ], "modifiers": [], "additional_components": [ "ENSXETT00000013293", "ENSXETT00000013820", "F6TTW7", "ENSXETT00000013820", "F7EHJ0", "ENSXETT00000013293" ] }, "reaction_10316215": { "compartment": "compartment_7660", "id": "reaction_10316215", "reactome": "R-XTR-211190", "name": "Caspase 3-mediated cleavage of DFF45 (117)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316213" ], "products": [ "species_10316192" ], "modifiers": [ [ "species_10316206", "catalyst" ] ], "additional_components": [ "F7EHJ0", "ENSXETT00000013293", "F6TTW7", "ENSXETT00000013820", "F6TTW7", "ENSXETT00000013820", "F7EHJ0", "ENSXETT00000013293", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10316209": { "compartment": "compartment_70101", "id": "reaction_10316209", "reactome": "R-XTR-211186", "name": "Cleavage of DFF45 (224) by caspase-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316192" ], "products": [ "species_10316198" ], "modifiers": [ [ "species_10316206", "catalyst" ] ], "additional_components": [ "F6TTW7", "ENSXETT00000013820", "F7EHJ0", "ENSXETT00000013293", "F6TTW7", "ENSXETT00000013820", "F7EHJ0", "ENSXETT00000013293", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10316073": { "compartment": "compartment_70101", "id": "reaction_10316073", "reactome": "R-XTR-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10316042" ], "products": [ "species_29420", "species_10316044" ], "modifiers": [ [ "species_10316070", "catalyst" ] ], "additional_components": [ "species_29420", "Q6GL60", "ENSXETT00000092508", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8QGS5", "ENSXETG00000038787", "F7DKF6", "ENSXETT00000044021", "A4II46", "ENSXETT00000074782", "A0A6I8Q734", "ENSXETG00000009131", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10316650": { "compartment": "compartment_984", "id": "reaction_10316650", "reactome": "R-XTR-265456", "name": "NPC1L1 inactivation by ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316646", "species_265479" ], "products": [ "species_10316648" ], "modifiers": [], "additional_components": [ "ENSXETG00000019001", "species_265479", "A0A6I8Q9Y0", "ENSXETG00000019001" ] }, "reaction_10330543": { "compartment": "compartment_70101", "id": "reaction_10330543", "reactome": "R-XTR-5675470", "name": "BIRC2/3 (cIAP1/2) is autoubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330519", "species_10329611" ], "products": [ "species_10330540" ], "modifiers": [ [ "species_10329611", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8QAZ5", "ENSXETG00000039278", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8QAZ5", "ENSXETG00000039278", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8QAZ5", "ENSXETG00000039278" ] }, "reaction_10338143": { "compartment": "compartment_70101", "id": "reaction_10338143", "reactome": "R-XTR-9688831", "name": "STUB1 ubiquitinates RIPK3 at K55, K363", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338134", "species_10312116" ], "products": [ "species_10338140" ], "modifiers": [ [ "species_10338134", "catalyst" ] ], "additional_components": [ "A0A6I8QJD3", "ENSXETG00000038971", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8QJD3", "ENSXETG00000038971", "A0A6I8QJD3", "ENSXETG00000038971" ] }, "reaction_10338120": { "compartment": "compartment_876", "id": "reaction_10338120", "reactome": "R-XTR-9686930", "name": "RIPK3 is cleaved by CASP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338114" ], "products": [ "species_10338118", "species_10338116" ], "modifiers": [ [ "species_10316682", "catalyst" ] ], "additional_components": [ "ENSXETG00000038971", "ENSXETG00000038971", "ENSXETG00000038971", "A0A6I8Q0P2", "ENSXETG00000032748" ] }, "reaction_10338145": { "compartment": "compartment_70101", "id": "reaction_10338145", "reactome": "R-XTR-9688838", "name": "RIPK3 binds STUB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338114", "species_10338132" ], "products": [ "species_10338134" ], "modifiers": [], "additional_components": [ "ENSXETG00000038971", "A0A6I8QJD3", "ENSXETG00000038971" ] }, "reaction_10338130": { "compartment": "compartment_70101", "id": "reaction_10338130", "reactome": "R-XTR-9687828", "name": "O-GlcNAcylation of RIPK3 (TLR4 signaling)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338114", "species_162756" ], "products": [ "species_10338123", "species_110096" ], "modifiers": [ [ "species_10338127", "catalyst" ] ], "additional_components": [ "ENSXETG00000038971", "ENSXETG00000038971", "ENSXETT00000034743" ] }, "reaction_10318991": { "compartment": "compartment_17906", "id": "reaction_10318991", "reactome": "R-XTR-508162", "name": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318987", "species_10312812" ], "products": [ "species_10318989" ], "modifiers": [], "additional_components": [ "ENSXETT00000050759", "ENSXETG00000031875", "A0A6I8PXS6", "ENSXETG00000031875", "F6XC18", "ENSXETT00000050759" ] }, "reaction_10312680": { "compartment": "compartment_17906", "id": "reaction_10312680", "reactome": "R-XTR-114263", "name": "Oligomerization of BAK at the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312676" ], "products": [ "species_10312678" ], "modifiers": [], "additional_components": [ "ENSXETG00000038338", "A0A6I8QFQ5", "ENSXETG00000038338" ] }, "reaction_10312692": { "compartment": "compartment_17906", "id": "reaction_10312692", "reactome": "R-XTR-114275", "name": "Oligomerization of BAX at the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312686" ], "products": [ "species_10312690" ], "modifiers": [], "additional_components": [ "ENSXETT00000031936", "F6TEC3", "ENSXETT00000031936" ] }, "reaction_10312688": { "compartment": "compartment_70101", "id": "reaction_10312688", "reactome": "R-XTR-114264", "name": "Translocation of activated BAX to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312684" ], "products": [ "species_10312686" ], "modifiers": [], "additional_components": [ "ENSXETT00000031936", "ENSXETT00000031936" ] }, "reaction_10312412": { "compartment": "compartment_7660", "id": "reaction_10312412", "reactome": "R-XTR-110218", "name": "Cleavage of uracil by TDG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312407" ], "products": [ "species_10312409", "species_29554" ], "modifiers": [ [ "species_10312407", "catalyst" ] ], "additional_components": [ "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927" ] }, "reaction_10312428": { "compartment": "compartment_7660", "id": "reaction_10312428", "reactome": "R-XTR-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312423" ], "products": [ "species_110223", "species_10312425" ], "modifiers": [ [ "species_10312423", "catalyst" ] ], "additional_components": [ "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540" ] }, "reaction_10312476": { "compartment": "compartment_7660", "id": "reaction_10312476", "reactome": "R-XTR-110234", "name": "Cleavage of ethenocytosine by TDG glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312473" ], "products": [ "species_110233", "species_10312409" ], "modifiers": [ [ "species_10312473", "catalyst" ] ], "additional_components": [ "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927" ] }, "reaction_10312398": { "compartment": "compartment_7660", "id": "reaction_10312398", "reactome": "R-XTR-110215", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312391" ], "products": [ "species_10312395", "species_29554" ], "modifiers": [ [ "species_10312391", "catalyst" ] ], "additional_components": [ "F6V364", "ENSXETT00000048248", "F6V364", "ENSXETT00000048248", "F6V364", "ENSXETT00000048248" ] }, "reaction_10312462": { "compartment": "compartment_7660", "id": "reaction_10312462", "reactome": "R-XTR-110231", "name": "Cleavage of uracil by MBD4 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312457" ], "products": [ "species_10312459", "species_29554" ], "modifiers": [ [ "species_10312457", "catalyst" ] ], "additional_components": [ "A0A6I8PM79", "ENSXETG00000026622", "A0A6I8PM79", "ENSXETG00000026622", "A0A6I8PM79", "ENSXETG00000026622" ] }, "reaction_10312442": { "compartment": "compartment_7660", "id": "reaction_10312442", "reactome": "R-XTR-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312439" ], "products": [ "species_30140", "species_10312425" ], "modifiers": [ [ "species_10312439", "catalyst" ] ], "additional_components": [ "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540" ] }, "reaction_10312405": { "compartment": "compartment_7660", "id": "reaction_10312405", "reactome": "R-XTR-110217", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312402" ], "products": [ "species_110216", "species_10312395" ], "modifiers": [ [ "species_10312402", "catalyst" ] ], "additional_components": [ "F6V364", "ENSXETT00000048248", "F6V364", "ENSXETT00000048248", "F6V364", "ENSXETT00000048248" ] }, "reaction_10312469": { "compartment": "compartment_7660", "id": "reaction_10312469", "reactome": "R-XTR-110232", "name": "Cleavage of thymine by MBD4 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312466" ], "products": [ "species_29692", "species_10312459" ], "modifiers": [ [ "species_10312466", "catalyst" ] ], "additional_components": [ "A0A6I8PM79", "ENSXETG00000026622", "A0A6I8PM79", "ENSXETG00000026622", "A0A6I8PM79", "ENSXETG00000026622" ] }, "reaction_10330164": { "compartment": "compartment_7660", "id": "reaction_10330164", "reactome": "R-XTR-5649681", "name": "NEIL2 cleaves 5-OHU from damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330159" ], "products": [ "species_10330161", "species_110216" ], "modifiers": [ [ "species_10330159", "catalyst" ] ], "additional_components": [ "F7D0D2", "ENSXETT00000051487", "F7D0D2", "ENSXETT00000051487", "F7D0D2", "ENSXETT00000051487" ] }, "reaction_10312449": { "compartment": "compartment_7660", "id": "reaction_10312449", "reactome": "R-XTR-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312446" ], "products": [ "species_5637659", "species_10312425" ], "modifiers": [ [ "species_10312446", "catalyst" ] ], "additional_components": [ "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540" ] }, "reaction_10312419": { "compartment": "compartment_7660", "id": "reaction_10312419", "reactome": "R-XTR-110219", "name": "Cleavage of thymine by TDG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312416" ], "products": [ "species_29692", "species_10312409" ], "modifiers": [ [ "species_10312416", "catalyst" ] ], "additional_components": [ "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927" ] }, "reaction_10312435": { "compartment": "compartment_7660", "id": "reaction_10312435", "reactome": "R-XTR-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312432" ], "products": [ "species_10312425", "species_110225" ], "modifiers": [ [ "species_10312432", "catalyst" ] ], "additional_components": [ "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540" ] }, "reaction_10316654": { "compartment": "compartment_984", "id": "reaction_10316654", "reactome": "R-XTR-266089", "name": "Discoidal HDL binds membrane-associated free cholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316576", "species_171095" ], "products": [ "species_10316652" ], "modifiers": [], "additional_components": [ "A0A6I8PU04", "ENSXETG00000033423", "species_171142", "species_216762", "A0A6I8PU04", "ENSXETG00000033423", "species_171142", "species_216762" ] }, "reaction_10316660": { "compartment": "compartment_984", "id": "reaction_10316660", "reactome": "R-XTR-266299", "name": "Spherical HDL binds membrane-associated free cholesterol and phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316656", "species_171095", "species_171142" ], "products": [ "species_10316658" ], "modifiers": [], "additional_components": [ "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "species_171142", "species_216762", "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "species_171142", "species_216762" ] }, "reaction_10331331": { "compartment": "compartment_984", "id": "reaction_10331331", "reactome": "R-XTR-5694109", "name": "LIPC dimer hydrolyses TAG to DAG and FA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_422024", "species_174675" ], "modifiers": [ [ "species_10331328", "catalyst" ] ], "additional_components": [ "species_1604784" ] }, "reaction_10332258": { "compartment": "compartment_984", "id": "reaction_10332258", "reactome": "R-XTR-6785213", "name": "LIPC dimer binds heparin", "reversible": "false", "notes": "", "reactants": [ "species_1604784", "species_10331326" ], "products": [ "species_10331328" ], "modifiers": [], "additional_components": [ "species_1604784" ] }, "reaction_10313538": { "compartment": "compartment_984", "id": "reaction_10313538", "reactome": "R-XTR-174739", "name": "chylomicron remnant + apoE => chylomicron remnant:apoE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313530", "species_10313532" ], "products": [ "species_10313534" ], "modifiers": [], "additional_components": [ "ENSXETT00000100802", "species_171126", "species_163579", "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "Q6P615", "ENSXETT00000100802", "species_216762", "species_171126", "species_163579", "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "Q6P615", "ENSXETT00000100802", "species_216762" ] }, "reaction_10317772": { "compartment": "compartment_204883", "id": "reaction_10317772", "reactome": "R-XTR-419001", "name": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140648", "species_10317768" ], "products": [ "species_10317770" ], "modifiers": [], "additional_components": [ "A0A6I8SWY9", "ENSXETG00000011269", "A0A6I8RR45", "ENSXETG00000020131", "F6XNI3", "ENSXETT00000034059", "A0A6I8SWY9", "ENSXETG00000011269", "A0A6I8RR45", "ENSXETG00000020131", "F6XNI3", "ENSXETT00000034059" ] }, "reaction_10318171": { "compartment": "compartment_876", "id": "reaction_10318171", "reactome": "R-XTR-433711", "name": "Cis-homodimerization of nectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317776" ], "products": [ "species_10317778" ], "modifiers": [], "additional_components": [ "ENSXETT00000020211", "F7E015", "ENSXETT00000020211" ] }, "reaction_10317893": { "compartment": "compartment_204883", "id": "reaction_10317893", "reactome": "R-XTR-420593", "name": "PVR:PVRL3 trans heterodimer interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317776", "species_10314618" ], "products": [ "species_10317891" ], "modifiers": [], "additional_components": [ "ENSXETT00000020211", "ENSXETG00000038811", "A0A6I8QUW8", "ENSXETG00000038811", "F7E015", "ENSXETT00000020211" ] }, "reaction_10317782": { "compartment": "compartment_204883", "id": "reaction_10317782", "reactome": "R-XTR-419011", "name": "Transhomodimerization of Nectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317778" ], "products": [ "species_10317780" ], "modifiers": [], "additional_components": [ "F7E015", "ENSXETT00000020211", "F7E015", "ENSXETT00000020211" ] }, "reaction_10331249": { "compartment": "compartment_984", "id": "reaction_10331249", "reactome": "R-XTR-5692437", "name": "ANG binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331241", "species_10331245" ], "products": [ "species_10331247" ], "modifiers": [], "additional_components": [ "ENSXETG00000038487", "A0A6I8R6T7", "ENSXETG00000038487" ] }, "reaction_10317889": { "compartment": "compartment_204883", "id": "reaction_10317889", "reactome": "R-XTR-420592", "name": "Transhomodimerization of Nectin-like (Necl) proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317885" ], "products": [ "species_10317887" ], "modifiers": [], "additional_components": [ "Q6DJ83", "ENSXETG00000026489", "Q6DJ83", "ENSXETG00000026489" ] }, "reaction_10337532": { "compartment": "compartment_70101", "id": "reaction_10337532", "reactome": "R-XTR-9023912", "name": "AGO2 cleaves passenger strand of duplex siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325973" ], "products": [ "species_10337529" ], "modifiers": [ [ "species_10325973", "catalyst" ] ], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "Q6DJB9", "ENSXETT00000051244", "Q6DJB9", "ENSXETT00000051244" ] }, "reaction_10317966": { "compartment": "compartment_70101", "id": "reaction_10317966", "reactome": "R-XTR-426464", "name": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426463", "species_10315976" ], "products": [ "species_10317963" ], "modifiers": [ [ "species_10315976", "catalyst" ] ], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175", "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175", "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175" ] }, "reaction_10325989": { "compartment": "compartment_70101", "id": "reaction_10325989", "reactome": "R-XTR-2106625", "name": "Duplex siRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317963" ], "products": [ "species_10325979" ], "modifiers": [], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175", "B3DLA6", "ENSXETT00000096069", "Q6DJB9", "ENSXETT00000051244", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175" ] }, "reaction_10325987": { "compartment": "compartment_70101", "id": "reaction_10325987", "reactome": "R-XTR-2106615", "name": "Removal of siRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325979" ], "products": [ "species_10325985" ], "modifiers": [], "additional_components": [ "B3DLA6", "ENSXETT00000096069", "Q6DJB9", "ENSXETT00000051244", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175", "B3DLA6", "ENSXETT00000096069", "A0A6I8S266", "ENSXETG00000036175", "Q6DJB9", "ENSXETT00000051244", "Q5BJ52", "ENSXETG00000012644" ] }, "reaction_10317981": { "compartment": "compartment_70101", "id": "reaction_10317981", "reactome": "R-XTR-426520", "name": "Endonucleolytic RISC hydrolyzes target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426523" ], "products": [ "species_426511" ], "modifiers": [ [ "species_10317970", "catalyst" ] ], "additional_components": [ "Q6DJB9", "ENSXETT00000051244" ] }, "reaction_10317978": { "compartment": "compartment_70101", "id": "reaction_10317978", "reactome": "R-XTR-426489", "name": "RISC binds inexactly matching target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317970", "species_10317974", "species_426515" ], "products": [ "species_10317976" ], "modifiers": [], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "ENSXETG00000030437", "A0A6I8RHW3", "ENSXETG00000030437", "Q6DJB9", "ENSXETT00000051244" ] }, "reaction_10316176": { "compartment": "compartment_70101", "id": "reaction_10316176", "reactome": "R-XTR-210805", "name": "Removal of miRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316164" ], "products": [ "species_10316174" ], "modifiers": [], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "A0A6I8S266", "ENSXETG00000036175", "Q5BJ52", "ENSXETG00000012644", "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175" ] }, "reaction_10325971": { "compartment": "compartment_70101", "id": "reaction_10325971", "reactome": "R-XTR-2106614", "name": "Duplex miRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325969" ], "products": [ "species_10316164" ], "modifiers": [], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "A0A6I8S266", "ENSXETG00000036175", "Q5BJ52", "ENSXETG00000012644", "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "A0A6I8S266", "ENSXETG00000036175", "Q5BJ52", "ENSXETG00000012644" ] }, "reaction_10329786": { "compartment": "compartment_70101", "id": "reaction_10329786", "reactome": "R-XTR-5578966", "name": "TNRC6A:AGO2:miRNA is transported into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329778" ], "products": [ "species_10329784" ], "modifiers": [], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "A0A6I8RHW3", "ENSXETG00000030437", "A0A6I8RHW3", "ENSXETG00000030437", "Q6DJB9", "ENSXETT00000051244" ] }, "reaction_10329780": { "compartment": "compartment_70101", "id": "reaction_10329780", "reactome": "R-XTR-5578965", "name": "TNRC6A binds AGO2:miRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317974", "species_10316168" ], "products": [ "species_10329778" ], "modifiers": [], "additional_components": [ "ENSXETG00000030437", "Q6DJB9", "ENSXETT00000051244", "Q6DJB9", "ENSXETT00000051244", "A0A6I8RHW3", "ENSXETG00000030437" ] }, "reaction_10316485": { "compartment": "compartment_7660", "id": "reaction_10316485", "reactome": "R-XTR-212252", "name": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316481", "species_10316457" ], "products": [ "species_10316483" ], "modifiers": [], "additional_components": [ "A0A6I8QJB3", "ENSXETG00000020362", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QJB3", "ENSXETG00000020362", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146" ] }, "reaction_10316517": { "compartment": "compartment_7660", "id": "reaction_10316517", "reactome": "R-XTR-212269", "name": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10316508" ], "products": [ "species_77502", "species_10316514" ], "modifiers": [ [ "species_10316508", "catalyst" ] ], "additional_components": [ "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146" ] }, "reaction_10316502": { "compartment": "compartment_7660", "id": "reaction_10316502", "reactome": "R-XTR-212263", "name": "PRC2 trimethylates histone H3 at lysine-27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10316483" ], "products": [ "species_77502", "species_10316499" ], "modifiers": [ [ "species_10316483", "catalyst" ] ], "additional_components": [ "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QJB3", "ENSXETG00000020362", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QJB3", "ENSXETG00000020362", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QJB3", "ENSXETG00000020362", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146" ] }, "reaction_10329316": { "compartment": "compartment_7660", "id": "reaction_10329316", "reactome": "R-XTR-5221061", "name": "TDG excises 5-carboxylcytosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5220996", "species_10312379" ], "products": [ "species_5221064", "species_10312409" ], "modifiers": [ [ "species_10312379", "catalyst" ] ], "additional_components": [ "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927", "ENSXETG00000025927" ] }, "reaction_10329314": { "compartment": "compartment_7660", "id": "reaction_10329314", "reactome": "R-XTR-5220959", "name": "TDG excises 5-formylcytosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5221062", "species_10312379" ], "products": [ "species_5221065", "species_10312409" ], "modifiers": [ [ "species_10312379", "catalyst" ] ], "additional_components": [ "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927", "ENSXETG00000025927" ] }, "reaction_10330834": { "compartment": "compartment_70101", "id": "reaction_10330834", "reactome": "R-XTR-5686315", "name": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312336" ], "products": [ "species_10312054", "species_10312334" ], "modifiers": [], "additional_components": [ "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387", "A0A6I8RAF1", "ENSXETG00000039550", "ENSXETG00000039550", "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10312039": { "compartment": "compartment_876", "id": "reaction_10312039", "reactome": "R-XTR-74734", "name": "Re-integration of insulin receptor into plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312037" ], "products": [ "species_10312021" ], "modifiers": [], "additional_components": [ "A0A6I8QUB9", "ENSXETG00000013518", "A0A6I8QUB9", "ENSXETG00000013518" ] }, "reaction_10322416": { "compartment": "compartment_876", "id": "reaction_10322416", "reactome": "R-XTR-1306957", "name": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10322413", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "A0A6I8RUB1", "ENSXETG00000007252" ] }, "reaction_10322418": { "compartment": "compartment_876", "id": "reaction_10322418", "reactome": "R-XTR-1306963", "name": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313814", "species_10322318" ], "products": [ "species_10322409" ], "modifiers": [], "additional_components": [ "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110" ] }, "reaction_10324487": { "compartment": "compartment_876", "id": "reaction_10324487", "reactome": "R-XTR-1963563", "name": "MATK (CSK homologous kinase) binds phosphorylated ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324483", "species_10322318" ], "products": [ "species_10324485" ], "modifiers": [], "additional_components": [ "ENSXETG00000032315", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "A0A6I8RYR6", "ENSXETG00000032315" ] }, "reaction_10335698": { "compartment": "compartment_876", "id": "reaction_10335698", "reactome": "R-XTR-8864125", "name": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335683", "species_29356" ], "products": [ "species_29372", "species_10335695" ], "modifiers": [ [ "species_10335683", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145" ] }, "reaction_10324503": { "compartment": "compartment_876", "id": "reaction_10324503", "reactome": "R-XTR-1963582", "name": "Trans-autophosphorylation of ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10324500" ], "products": [ "species_29370", "species_10322311" ], "modifiers": [ [ "species_10324500", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145" ] }, "reaction_10322327": { "compartment": "compartment_876", "id": "reaction_10322327", "reactome": "R-XTR-1250195", "name": "SHC1 phosphorylation by ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322320", "species_113592" ], "products": [ "species_29370", "species_10322324" ], "modifiers": [ [ "species_10322320", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145" ] }, "reaction_10332266": { "compartment": "compartment_70101", "id": "reaction_10332266", "reactome": "R-XTR-6785636", "name": "Phosphorylated ERBB2 heterodimers bind MEMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10332262", "species_10322318" ], "products": [ "species_10332264" ], "modifiers": [], "additional_components": [ "ENSXETT00000018710", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "Q6DJ03", "ENSXETT00000018710" ] }, "reaction_10324496": { "compartment": "compartment_876", "id": "reaction_10324496", "reactome": "R-XTR-1963581", "name": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10324493" ], "products": [ "species_29370", "species_10322316" ], "modifiers": [ [ "species_10324493", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145" ] }, "reaction_10322488": { "compartment": "compartment_70101", "id": "reaction_10322488", "reactome": "R-XTR-1433415", "name": "Activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317330", "species_29438" ], "products": [ "species_29420", "species_10312717" ], "modifiers": [ [ "species_10322485", "catalyst" ] ], "additional_components": [ "species_29420", "Q6GL60", "ENSXETT00000092508", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10312285": { "compartment": "compartment_876", "id": "reaction_10312285", "reactome": "R-XTR-83660", "name": "Membrane-anchored TNF-alpha binds TNFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312281", "species_10312271" ], "products": [ "species_10312279", "species_10312283" ], "modifiers": [], "additional_components": [ "F6X123", "ENSXETT00000023023", "A0A6I8PW21", "ENSXETG00000032118", "ENSXETT00000023023", "A0A6I8PW21", "ENSXETG00000032118" ] }, "reaction_10327781": { "compartment": "compartment_876", "id": "reaction_10327781", "reactome": "R-XTR-3371353", "name": "Soluble TNF-alpha binds TNFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327777", "species_10312281" ], "products": [ "species_10327779", "species_10312279" ], "modifiers": [], "additional_components": [ "F6X123", "ENSXETT00000023023", "A0A6I8PW21", "ENSXETG00000032118", "A0A6I8PW21", "ENSXETG00000032118", "ENSXETT00000023023" ] }, "reaction_10337807": { "compartment": "compartment_876", "id": "reaction_10337807", "reactome": "R-XTR-9624272", "name": "MMPs cleave HB-EGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337798" ], "products": [ "species_10337800", "species_10313836" ], "modifiers": [ [ "species_10337802", "catalyst" ], [ "species_10337805", "catalyst" ] ], "additional_components": [ "ENSXETG00000039798", "ENSXETG00000039798", "ENSXETG00000039798", "A0A6I8PRW9", "ENSXETG00000033700", "species_428203" ] }, "reaction_10337899": { "compartment": "compartment_7660", "id": "reaction_10337899", "reactome": "R-XTR-9632873", "name": "p-S10 CDKN1B translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337895" ], "products": [ "species_10337897" ], "modifiers": [], "additional_components": [ "ENSXETG00000038125", "ENSXETG00000038125" ] }, "reaction_10337824": { "compartment": "compartment_876", "id": "reaction_10337824", "reactome": "R-XTR-9625813", "name": "S1P binds S1PR3 in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5218688", "species_10317807" ], "products": [ "species_10337805" ], "modifiers": [], "additional_components": [ "ENSXETG00000033700", "A0A6I8PRW9", "ENSXETG00000033700", "species_428203" ] }, "reaction_10313536": { "compartment": "compartment_17957", "id": "reaction_10313536", "reactome": "R-XTR-174731", "name": "Degradation of newly synthesized ApoB-48", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313490" ], "products": [], "modifiers": [], "additional_components": [ "ENSXETG00000026768" ] }, "reaction_10335790": { "compartment": "compartment_17960", "id": "reaction_10335790", "reactome": "R-XTR-8866327", "name": "VLDL translocates from SER lumen to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335778" ], "products": [ "species_10335788" ], "modifiers": [], "additional_components": [ "species_171142", "species_171126", "species_216762", "species_163579", "A0A6I8RKY6", "ENSXETG00000026768", "species_171126", "A0A6I8RKY6", "ENSXETG00000026768", "species_163579", "species_171142", "species_216762" ] }, "reaction_10335786": { "compartment": "compartment_17960", "id": "reaction_10335786", "reactome": "R-XTR-8866308", "name": "pre-VLDL translocates from RER membrane to SER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335784" ], "products": [ "species_10335776" ], "modifiers": [], "additional_components": [ "species_171126", "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "species_171126" ] }, "reaction_10335780": { "compartment": "compartment_70101", "id": "reaction_10335780", "reactome": "R-XTR-8866304", "name": "pre-VLDL binds lipids to form VLDL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335776", "species_8866316", "species_8866305", "species_8866307", "species_8866324" ], "products": [ "species_10335778" ], "modifiers": [], "additional_components": [ "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "species_171126", "species_171142", "species_171126", "species_216762", "species_163579", "A0A6I8RKY6", "ENSXETG00000026768" ] }, "reaction_10330351": { "compartment": "compartment_70101", "id": "reaction_10330351", "reactome": "R-XTR-5661217", "name": "MT1A binds zinc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330347", "species_29426" ], "products": [ "species_10330349" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "species_29426", "A0A6I8RW79", "ENSXETG00000030675" ] }, "reaction_10330383": { "compartment": "compartment_70101", "id": "reaction_10330383", "reactome": "R-XTR-5662620", "name": "MT3 binds cadmium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1132098", "species_10330367" ], "products": [ "species_10330381" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "A0A6I8RW79", "ENSXETG00000030675", "species_1132098" ] }, "reaction_10330379": { "compartment": "compartment_70101", "id": "reaction_10330379", "reactome": "R-XTR-5662613", "name": "MT3 exchanges zinc for copper", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330369", "species_209799" ], "products": [ "species_10330377", "species_29426" ], "modifiers": [], "additional_components": [ "A0A6I8RW79", "ENSXETG00000030675", "species_29426", "A0A6I8RW79", "ENSXETG00000030675", "species_29426", "species_3299744" ] }, "reaction_10330375": { "compartment": "compartment_70101", "id": "reaction_10330375", "reactome": "R-XTR-5662608", "name": "MT2A binds cadmium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330347", "species_1132098" ], "products": [ "species_10330373" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "species_1132098", "A0A6I8RW79", "ENSXETG00000030675" ] }, "reaction_10330355": { "compartment": "compartment_70101", "id": "reaction_10330355", "reactome": "R-XTR-5661230", "name": "MT1A binds arsenic", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5661216", "species_10330347" ], "products": [ "species_10330353" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "A0A6I8RW79", "ENSXETG00000030675", "species_5661216" ] }, "reaction_10330387": { "compartment": "compartment_70101", "id": "reaction_10330387", "reactome": "R-XTR-5662986", "name": "MT2A binds copper", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330347", "species_3299744" ], "products": [ "species_10330385" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "species_3299744", "A0A6I8RW79", "ENSXETG00000030675" ] }, "reaction_10330371": { "compartment": "compartment_70101", "id": "reaction_10330371", "reactome": "R-XTR-5662606", "name": "MT3 binds zinc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426", "species_10330367" ], "products": [ "species_10330369" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "A0A6I8RW79", "ENSXETG00000030675", "species_29426" ] }, "reaction_10330863": { "compartment": "compartment_70101", "id": "reaction_10330863", "reactome": "R-XTR-5687107", "name": "MAPK4,6 translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330857" ], "products": [ "species_10330861" ], "modifiers": [], "additional_components": [ "A0A6I8RH21", "ENSXETG00000038723", "A0A6I8RH21", "ENSXETG00000038723" ] }, "reaction_10330849": { "compartment": "compartment_70101", "id": "reaction_10330849", "reactome": "R-XTR-5687086", "name": "PAK1,2,3 phosphorylates MAPK6,4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10330843" ], "products": [ "species_29370", "species_10330846" ], "modifiers": [ [ "species_10329598", "catalyst" ] ], "additional_components": [ "ENSXETG00000038723", "ENSXETG00000038723", "ENSXETG00000011808" ] }, "reaction_10338027": { "compartment": "compartment_12045", "id": "reaction_10338027", "reactome": "R-XTR-9653514", "name": "USP17L2 deubiquitinates RCE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10338022" ], "products": [ "species_10338024", "species_10331757" ], "modifiers": [ [ "species_10331547", "catalyst" ] ], "additional_components": [ "ENSXETT00000056088", "ENSXETT00000056088", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "ENSXETT00000015033" ] }, "reaction_10338001": { "compartment": "compartment_876", "id": "reaction_10338001", "reactome": "R-XTR-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10337997" ], "products": [ "species_10337999" ], "modifiers": [], "additional_components": [ "Q6GL10", "ENSXETT00000004138", "Q6DEY3", "ENSXETT00000057305", "Q6GL10", "ENSXETT00000004138", "Q6DEY3", "ENSXETT00000057305" ] }, "reaction_10330310": { "compartment": "compartment_876", "id": "reaction_10330310", "reactome": "R-XTR-5658438", "name": "SPRED dimer binds NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330297", "species_10330301" ], "products": [ "species_10330303" ], "modifiers": [], "additional_components": [ "Q66JG9", "ENSXETT00000039156", "ENSXETG00000021350", "A0A6I8R7X8", "ENSXETG00000021350", "Q66JG9", "ENSXETT00000039156" ] }, "reaction_10337357": { "compartment": "compartment_70101", "id": "reaction_10337357", "reactome": "R-XTR-9014294", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312723", "species_10337353" ], "products": [ "species_10337355" ], "modifiers": [], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "A0A6I8SQB3", "ENSXETG00000005314", "A0A6I8S090", "ENSXETG00000032218", "A0A6I8SQB3", "ENSXETG00000005314", "A0A6I8S090", "ENSXETG00000032218", "F7DEH8", "ENSXETT00000009928", "species_29438" ] }, "reaction_10337369": { "compartment": "compartment_876", "id": "reaction_10337369", "reactome": "R-XTR-9014420", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312723" ], "products": [ "species_10330417" ], "modifiers": [], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "F7DEH8", "ENSXETT00000009928", "species_29438" ] }, "reaction_10338297": { "compartment": "compartment_876", "id": "reaction_10338297", "reactome": "R-XTR-9714483", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312723" ], "products": [ "species_10338295" ], "modifiers": [], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "F7DEH8", "ENSXETT00000009928", "species_29438" ] }, "reaction_10337367": { "compartment": "compartment_70101", "id": "reaction_10337367", "reactome": "R-XTR-9014296", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10337351" ], "products": [ "species_10312723", "species_29420" ], "modifiers": [ [ "species_10337364", "catalyst" ] ], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29420", "F7DEH8", "ENSXETT00000009928", "species_29438", "A4II46", "ENSXETT00000074782", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10338289": { "compartment": "compartment_17906", "id": "reaction_10338289", "reactome": "R-XTR-9714477", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338279", "species_10338285" ], "products": [ "species_10338287" ], "modifiers": [], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "F7DEH8", "ENSXETT00000009928", "species_29438" ] }, "reaction_10338291": { "compartment": "compartment_876", "id": "reaction_10338291", "reactome": "R-XTR-9714480", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312723" ], "products": [ "species_10338279" ], "modifiers": [], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "F7DEH8", "ENSXETT00000009928", "species_29438" ] }, "reaction_10337362": { "compartment": "compartment_70101", "id": "reaction_10337362", "reactome": "R-XTR-9014295", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312723", "species_29356" ], "products": [ "species_29372", "species_10337351" ], "modifiers": [ [ "species_10337359", "catalyst" ] ], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "F7DEH8", "ENSXETT00000009928", "species_29420", "A0A6I8QIL4", "ENSXETG00000001985", "B5DFQ4", "ENSXETT00000003971" ] }, "reaction_10311975": { "compartment": "compartment_876", "id": "reaction_10311975", "reactome": "R-XTR-73945", "name": "FAS-mediated dimerization of procaspase-8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311969", "species_10311967" ], "products": [ "species_10311973" ], "modifiers": [], "additional_components": [ "A0A6I8Q0P2", "ENSXETG00000032748", "A0A6I8PTW1", "ENSXETG00000031916", "A0A6I8QWZ8", "ENSXETG00000041356", "ENSXETG00000032748", "A0A6I8PTW1", "ENSXETG00000031916", "A0A6I8QWZ8", "ENSXETG00000041356", "A0A6I8Q0P2", "ENSXETG00000032748" ] }, "reaction_10338303": { "compartment": "compartment_876", "id": "reaction_10338303", "reactome": "R-XTR-9714694", "name": "RAC3 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337426" ], "products": [ "species_10338301" ], "modifiers": [], "additional_components": [ "species_29438", "species_29438" ] }, "reaction_10337431": { "compartment": "compartment_876", "id": "reaction_10337431", "reactome": "R-XTR-9018806", "name": "RAC3 GAPs stimulate RAC3 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337426", "species_29356" ], "products": [ "species_10337424", "species_29372" ], "modifiers": [ [ "species_10337428", "catalyst" ] ], "additional_components": [ "species_29438", "species_29420", "A0A6I8QIL4", "ENSXETG00000001985", "B5DFQ4", "ENSXETT00000003971" ] }, "reaction_10337441": { "compartment": "compartment_876", "id": "reaction_10337441", "reactome": "R-XTR-9018807", "name": "RAC3 GDIs block activation of RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337424", "species_10337433" ], "products": [ "species_10337439" ], "modifiers": [], "additional_components": [ "species_29420", "species_29420" ] }, "reaction_10337386": { "compartment": "compartment_70101", "id": "reaction_10337386", "reactome": "R-XTR-9018745", "name": "RHOQ GAPs stimulate RHOQ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337379", "species_29356" ], "products": [ "species_29372", "species_10337381" ], "modifiers": [ [ "species_10337383", "catalyst" ] ], "additional_components": [ "F6ZQ78", "ENSXETT00000010273", "species_29438", "F6ZQ78", "ENSXETT00000010273", "species_29420", "A0A6I8QIL4", "ENSXETG00000001985", "A0A6I8T1P4", "ENSXETG00000005630", "B5DFQ4", "ENSXETT00000003971" ] }, "reaction_10337474": { "compartment": "compartment_876", "id": "reaction_10337474", "reactome": "R-XTR-9018836", "name": "RHOQ translocates to the Golgi-associated vesicle membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337379" ], "products": [ "species_10337472" ], "modifiers": [], "additional_components": [ "F6ZQ78", "ENSXETT00000010273", "species_29438", "F6ZQ78", "ENSXETT00000010273", "species_29438" ] }, "reaction_10337263": { "compartment": "compartment_70101", "id": "reaction_10337263", "reactome": "R-XTR-9013024", "name": "RHOB binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337259", "species_10317689" ], "products": [ "species_10337261" ], "modifiers": [], "additional_components": [ "A0A6I8R6D3", "ENSXETG00000006092", "A0A6I8SJ25", "ENSXETG00000017030", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8Q6H0", "ENSXETG00000023782", "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8R6D3", "ENSXETG00000006092", "A0A6I8SJ25", "ENSXETG00000017030", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8Q6H0", "ENSXETG00000023782" ] }, "reaction_10338159": { "compartment": "compartment_74700", "id": "reaction_10338159", "reactome": "R-XTR-9690493", "name": "RHOB binds effectors on endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338155", "species_10330399" ], "products": [ "species_10338157" ], "modifiers": [], "additional_components": [ "A0A6I8R8W7", "ENSXETG00000018271", "A0A6I8RD71", "ENSXETG00000018144", "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8R8W7", "ENSXETG00000018271", "A0A6I8RD71", "ENSXETG00000018144" ] }, "reaction_10337240": { "compartment": "compartment_70101", "id": "reaction_10337240", "reactome": "R-XTR-9013022", "name": "RHOB GAPs stimulate RHOB GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10317689" ], "products": [ "species_29372", "species_10337201" ], "modifiers": [ [ "species_10337237", "catalyst" ] ], "additional_components": [ "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29420", "A0A6I8QIL4", "ENSXETG00000001985", "A4II46", "ENSXETT00000074782", "A0A6I8T1P4", "ENSXETG00000005630", "B5DFQ4", "ENSXETT00000003971" ] }, "reaction_10337243": { "compartment": "compartment_876", "id": "reaction_10337243", "reactome": "R-XTR-9013023", "name": "RHOB GEFs activate RHOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10337201" ], "products": [ "species_29420", "species_10317689" ], "modifiers": [ [ "species_10316060", "catalyst" ] ], "additional_components": [ "Q6NVL3", "ENSXETT00000056231", "species_29420", "Q6NVL3", "ENSXETT00000056231", "species_29438", "ENSXETG00000038787" ] }, "reaction_10337211": { "compartment": "compartment_70101", "id": "reaction_10337211", "reactome": "R-XTR-9013021", "name": "GDIs block activation of RHOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337201", "species_10337205" ], "products": [ "species_10337209" ], "modifiers": [], "additional_components": [ "Q6NVL3", "ENSXETT00000056231", "species_29420", "ENSXETT00000020510", "F7D6Y2", "ENSXETT00000020510", "Q6NVL3", "ENSXETT00000056231", "species_29420" ] }, "reaction_10338161": { "compartment": "compartment_876", "id": "reaction_10338161", "reactome": "R-XTR-9690494", "name": "RHOB translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317689" ], "products": [ "species_10330399" ], "modifiers": [], "additional_components": [ "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438" ] }, "reaction_10337468": { "compartment": "compartment_70101", "id": "reaction_10337468", "reactome": "R-XTR-9018826", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10337449" ], "products": [ "species_29372", "species_10337465" ], "modifiers": [ [ "species_10337449", "catalyst" ] ], "additional_components": [ "Q6DIS1", "ENSXETT00000007838", "species_29438", "Q6DIS1", "ENSXETT00000007838", "species_29420", "Q6DIS1", "ENSXETT00000007838", "species_29438" ] }, "reaction_10337463": { "compartment": "compartment_70101", "id": "reaction_10337463", "reactome": "R-XTR-9018824", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337459", "species_10337449" ], "products": [ "species_10337461" ], "modifiers": [], "additional_components": [ "A0A6I8RC59", "ENSXETG00000013857", "A0A6I8RIZ7", "ENSXETG00000032904", "Q6DIS1", "ENSXETT00000007838", "species_29438", "Q6DIS1", "ENSXETT00000007838", "species_29438", "A0A6I8RC59", "ENSXETG00000013857", "A0A6I8RIZ7", "ENSXETG00000032904" ] }, "reaction_10329821": { "compartment": "compartment_984", "id": "reaction_10329821", "reactome": "R-XTR-5607023", "name": "factor IXa associates with cell membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312873" ], "products": [ "species_10312962" ], "modifiers": [], "additional_components": [ "Q5M8Y0", "ENSXETT00000025939", "Q5M8Y0", "ENSXETT00000025939" ] }, "reaction_10312988": { "compartment": "compartment_984", "id": "reaction_10312988", "reactome": "R-XTR-158340", "name": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312984", "species_10312972" ], "products": [ "species_10312986" ], "modifiers": [], "additional_components": [ "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942", "A0A6I8S6I3", "ENSXETG00000005867", "A0A6I8S6I3", "ENSXETG00000005867", "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942" ] }, "reaction_10329823": { "compartment": "compartment_984", "id": "reaction_10329823", "reactome": "R-XTR-5607043", "name": "factor VIIIa associates with cell membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312938" ], "products": [ "species_10312956" ], "modifiers": [], "additional_components": [ "A0A6I8SC83", "ENSXETG00000038196", "A0A6I8SC83", "ENSXETG00000038196" ] }, "reaction_10338059": { "compartment": "compartment_17957", "id": "reaction_10338059", "reactome": "R-XTR-9670673", "name": "FIX is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338057" ], "products": [ "species_10312867" ], "modifiers": [], "additional_components": [ "ENSXETT00000025939", "ENSXETT00000025939" ] }, "reaction_10338055": { "compartment": "compartment_984", "id": "reaction_10338055", "reactome": "R-XTR-9670014", "name": "Factor VIIIa dissociates ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312938" ], "products": [ "species_10312934", "species_10338053" ], "modifiers": [], "additional_components": [ "A0A6I8SC83", "ENSXETG00000038196", "ENSXETG00000038196", "A0A6I8SC83", "ENSXETG00000038196" ] }, "reaction_10312966": { "compartment": "compartment_984", "id": "reaction_10312966", "reactome": "R-XTR-158278", "name": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312962", "species_10312956" ], "products": [ "species_10312964" ], "modifiers": [ [ "species_74112", "catalyst" ] ], "additional_components": [ "Q5M8Y0", "ENSXETT00000025939", "A0A6I8SC83", "ENSXETG00000038196", "A0A6I8SC83", "ENSXETG00000038196", "Q5M8Y0", "ENSXETT00000025939" ] }, "reaction_10338033": { "compartment": "compartment_17957", "id": "reaction_10338033", "reactome": "R-XTR-9661625", "name": "FVIII is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331360" ], "products": [ "species_10312922" ], "modifiers": [], "additional_components": [ "ENSXETG00000038196", "A0A6I8SC83", "ENSXETG00000038196" ] }, "reaction_10312930": { "compartment": "compartment_984", "id": "reaction_10312930", "reactome": "R-XTR-158118", "name": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312922", "species_10312926" ], "products": [ "species_10312928" ], "modifiers": [], "additional_components": [ "A0A6I8SC83", "ENSXETG00000038196", "F6TMK5", "ENSXETT00000046700", "F6TMK5", "ENSXETT00000046700", "A0A6I8SC83", "ENSXETG00000038196" ] }, "reaction_10330109": { "compartment": "compartment_5263228", "id": "reaction_10330109", "reactome": "R-XTR-5635843", "name": "GLI translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330107" ], "products": [ "species_10330101" ], "modifiers": [], "additional_components": [ "ENSXETG00000036606", "ENSXETG00000036606" ] }, "reaction_10330074": { "compartment": "compartment_261122", "id": "reaction_10330074", "reactome": "R-XTR-5632677", "name": "PTCH is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330070" ], "products": [ "species_10330072" ], "modifiers": [], "additional_components": [ "ENSXETG00000014834", "ENSXETG00000014834" ] }, "reaction_10330132": { "compartment": "compartment_7660", "id": "reaction_10330132", "reactome": "R-XTR-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330129", "species_10327687" ], "products": [ "species_10330125" ], "modifiers": [ [ "species_10330129", "catalyst" ] ], "additional_components": [ "A4IHP4", "ENSXETT00000017945", "Q6P8B3", "ENSXETT00000057841", "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A4IHP4", "ENSXETT00000017945", "Q6P8B3", "ENSXETT00000057841", "A0A6I8S0I4", "ENSXETG00000035313", "A4IHP4", "ENSXETT00000017945", "Q6P8B3", "ENSXETT00000057841", "A0A6I8S0I4", "ENSXETG00000035313" ] }, "reaction_10330098": { "compartment": "compartment_261122", "id": "reaction_10330098", "reactome": "R-XTR-5635102", "name": "GPR161 is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329842" ], "products": [ "species_10330096" ], "modifiers": [], "additional_components": [ "ENSXETG00000002410", "ENSXETG00000002410" ] }, "reaction_10329881": { "compartment": "compartment_20699", "id": "reaction_10329881", "reactome": "R-XTR-5617828", "name": "TRIP11:IFT20 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329879" ], "products": [ "species_10329873", "species_10329877" ], "modifiers": [], "additional_components": [ "A0A6I8SZZ2", "ENSXETG00000015833", "Q66KL7", "ENSXETT00000069320", "ENSXETT00000069320", "ENSXETG00000015833" ] }, "reaction_10321867": { "compartment": "compartment_70101", "id": "reaction_10321867", "reactome": "R-XTR-1183128", "name": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1183111" ], "products": [ "species_29382", "species_1183191" ], "modifiers": [ [ "species_10321864", "catalyst" ] ], "additional_components": [ "species_74112", "F6YPC2", "ENSXETT00000038130" ] }, "reaction_10328860": { "compartment": "compartment_7660", "id": "reaction_10328860", "reactome": "R-XTR-4722133", "name": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328853", "species_113671", "species_113685" ], "products": [ "species_29478", "species_10327320", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328857", "catalyst" ] ], "additional_components": [ "ENSXETT00000070583" ] }, "reaction_10327327": { "compartment": "compartment_7660", "id": "reaction_10327327", "reactome": "R-XTR-3214912", "name": "KDM1A, KDM1B demethylate MeK5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327318" ], "products": [ "species_29478", "species_10327320" ], "modifiers": [ [ "species_10327324", "catalyst" ] ], "additional_components": [ "ENSXETG00000015429" ] }, "reaction_10328879": { "compartment": "compartment_7660", "id": "reaction_10328879", "reactome": "R-XTR-4724284", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328864", "species_113671", "species_113685" ], "products": [ "species_29478", "species_10327320", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328876", "catalyst" ] ], "additional_components": [ "Q08D35", "ENSXETG00000002669", "A0A6I8Q587", "ENSXETG00000006700" ] }, "reaction_10330334": { "compartment": "compartment_7660", "id": "reaction_10330334", "reactome": "R-XTR-5661121", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10330190" ], "products": [ "species_10328898", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328914", "catalyst" ] ], "additional_components": [ "A0A6I8S4K7", "ENSXETG00000004822", "Q08D35", "ENSXETG00000002669" ] }, "reaction_10328890": { "compartment": "compartment_7660", "id": "reaction_10328890", "reactome": "R-XTR-4754181", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328881", "species_113671", "species_113685" ], "products": [ "species_10327318", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328885", "catalyst" ] ], "additional_components": [ "ENSXETT00000007540" ] }, "reaction_10328917": { "compartment": "compartment_7660", "id": "reaction_10328917", "reactome": "R-XTR-4754187", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328898", "species_113671", "species_113685" ], "products": [ "species_10328906", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328914", "catalyst" ] ], "additional_components": [ "A0A6I8S4K7", "ENSXETG00000004822", "Q08D35", "ENSXETG00000002669" ] }, "reaction_10330324": { "compartment": "compartment_7660", "id": "reaction_10330324", "reactome": "R-XTR-5661116", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329431", "species_113671", "species_113685" ], "products": [ "species_10328881", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328885", "catalyst" ] ], "additional_components": [ "ENSXETT00000007540" ] }, "reaction_10330320": { "compartment": "compartment_7660", "id": "reaction_10330320", "reactome": "R-XTR-5661114", "name": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330145", "species_113671", "species_113685" ], "products": [ "species_10328853", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328857", "catalyst" ] ], "additional_components": [ "ENSXETT00000070583" ] }, "reaction_10330338": { "compartment": "compartment_7660", "id": "reaction_10330338", "reactome": "R-XTR-5661123", "name": "KDM1A, KDM1B demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328881" ], "products": [ "species_10327318", "species_29478" ], "modifiers": [ [ "species_10327324", "catalyst" ] ], "additional_components": [ "ENSXETG00000015429" ] }, "reaction_10330322": { "compartment": "compartment_7660", "id": "reaction_10330322", "reactome": "R-XTR-5661115", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10328862" ], "products": [ "species_10328864", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328876", "catalyst" ] ], "additional_components": [ "Q08D35", "ENSXETG00000002669", "A0A6I8Q587", "ENSXETG00000006700" ] }, "reaction_10327428": { "compartment": "compartment_7660", "id": "reaction_10327428", "reactome": "R-XTR-3247569", "name": "PADI4 deiminates Histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10327386" ], "products": [ "species_76230", "species_10327417" ], "modifiers": [ [ "species_10327419", "catalyst" ] ], "additional_components": [ "ENSXETT00000038130" ] }, "reaction_10329663": { "compartment": "compartment_7660", "id": "reaction_10329663", "reactome": "R-XTR-5423038", "name": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313794", "species_77087" ], "products": [ "species_77502", "species_10326319" ], "modifiers": [ [ "species_10326655", "catalyst" ] ], "additional_components": [ "ENSXETG00000035354", "ENSXETG00000035354", "ENSXETT00000012803" ] }, "reaction_10330137": { "compartment": "compartment_7660", "id": "reaction_10330137", "reactome": "R-XTR-5637686", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10327318" ], "products": [ "species_77502", "species_10328881" ], "modifiers": [ [ "species_10330134", "catalyst" ] ], "additional_components": [ "B7ZUF3", "ENSXETT00000065894", "A0A6I8S8Z5", "ENSXETG00000040375" ] }, "reaction_10335723": { "compartment": "compartment_7660", "id": "reaction_10335723", "reactome": "R-XTR-8865237", "name": "SETD6 methylates RELA in the NFkB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10313349" ], "products": [ "species_77502", "species_10335716" ], "modifiers": [ [ "species_10335720", "catalyst" ] ], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "ENSXETG00000013793" ] }, "reaction_10329450": { "compartment": "compartment_7660", "id": "reaction_10329450", "reactome": "R-XTR-5244692", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10328881" ], "products": [ "species_77502", "species_10329431" ], "modifiers": [ [ "species_10329447", "catalyst" ], [ "species_10329122", "inhibitor" ] ], "additional_components": [ "A0A6I8S8Z5", "ENSXETG00000040375", "A0A6I8RD53", "ENSXETG00000039708", "A0A6I8SUP9", "ENSXETG00000037286" ] }, "reaction_10328986": { "compartment": "compartment_7660", "id": "reaction_10328986", "reactome": "R-XTR-4827382", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10328862" ], "products": [ "species_77502", "species_10328969" ], "modifiers": [ [ "species_10328983", "catalyst" ] ], "additional_components": [ "Q28CQ7", "ENSXETG00000005401", "A4IGY9", "ENSXETG00000015666", "Q08D57", "ENSXETG00000003760" ] }, "reaction_10328999": { "compartment": "compartment_7660", "id": "reaction_10328999", "reactome": "R-XTR-5159245", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10327320" ], "products": [ "species_77502", "species_10327318" ], "modifiers": [ [ "species_10328996", "catalyst" ] ], "additional_components": [ "B7ZUF3", "ENSXETT00000065894", "Q4QQN5", "ENSXETT00000036910" ] }, "reaction_10314063": { "compartment": "compartment_876", "id": "reaction_10314063", "reactome": "R-XTR-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10314060", "catalyst" ] ], "additional_components": [ "ENSXETT00000048392" ] }, "reaction_10336095": { "compartment": "compartment_876", "id": "reaction_10336095", "reactome": "R-XTR-8932955", "name": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189227", "species_74113" ], "products": [ "species_83910", "species_189254" ], "modifiers": [ [ "species_10336092", "catalyst" ] ], "additional_components": [ "species_188995", "species_70113", "species_70113", "species_188995", "ENSXETG00000036486" ] }, "reaction_10317056": { "compartment": "compartment_876", "id": "reaction_10317056", "reactome": "R-XTR-376122", "name": "DSCAM/DSCAML1 homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317052" ], "products": [ "species_10317054" ], "modifiers": [], "additional_components": [ "ENSXETG00000003741", "A0A6I8S5X4", "ENSXETG00000003741" ] }, "reaction_10322283": { "compartment": "compartment_70101", "id": "reaction_10322283", "reactome": "R-XTR-1237325", "name": "Hemoglobin A is protonated and carbamated causing release of oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113528", "species_10322261" ], "products": [ "species_29368", "species_10322281" ], "modifiers": [], "additional_components": [ "species_189444", "P07428", "ENSXETT00000002494", "species_113533", "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566", "species_189444", "P07428", "ENSXETT00000002494", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627" ] }, "reaction_10334487": { "compartment": "compartment_70101", "id": "reaction_10334487", "reactome": "R-XTR-6806831", "name": "CYB5Rs reduce MetHb to HbA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334462", "species_73473" ], "products": [ "species_70106", "species_10334468", "species_29360" ], "modifiers": [ [ "species_10334484", "catalyst" ] ], "additional_components": [ "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566", "species_917955", "P07428", "ENSXETT00000002494", "species_189444", "P07428", "ENSXETT00000002494", "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566", "Q5BJ68", "ENSXETT00000096157", "A0A6I8SMQ8", "ENSXETG00000035257", "Q28CZ9", "ENSXETG00000022592" ] }, "reaction_10322214": { "compartment": "compartment_984", "id": "reaction_10322214", "reactome": "R-XTR-1237047", "name": "CA4:Zn2+ hydrates CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10322211", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8QID1", "ENSXETG00000034545" ] }, "reaction_10335965": { "compartment": "compartment_171907", "id": "reaction_10335965", "reactome": "R-XTR-8876366", "name": "LDL translocates from endosome lumen to lysosome lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335963" ], "products": [ "species_10335734" ], "modifiers": [], "additional_components": [ "species_163579", "A0A6I8RKY6", "ENSXETG00000026768", "species_216762", "species_171126", "species_171142", "species_171126", "species_171142", "species_163579", "species_216762", "A0A6I8RKY6", "ENSXETG00000026768" ] }, "reaction_10335741": { "compartment": "compartment_161320", "id": "reaction_10335741", "reactome": "R-XTR-8865667", "name": "LIPA hydrolyses sterol esters to sterols and fatty acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_10335734" ], "products": [ "species_8848047", "species_10335736", "species_8865666" ], "modifiers": [ [ "species_10335738", "catalyst" ] ], "additional_components": [ "species_171126", "species_171142", "species_163579", "species_216762", "A0A6I8RKY6", "ENSXETG00000026768", "species_171126", "species_171142", "species_216762", "A0A6I8RKY6", "ENSXETG00000026768", "ENSXETT00000020371" ] }, "reaction_10334653": { "compartment": "compartment_70101", "id": "reaction_10334653", "reactome": "R-XTR-6813720", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10334650", "catalyst" ] ], "additional_components": [ "ENSXETG00000038694" ] }, "reaction_10335991": { "compartment": "compartment_12045", "id": "reaction_10335991", "reactome": "R-XTR-8876696", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384", "species_1500578" ], "products": [ "species_8876704", "species_76194" ], "modifiers": [ [ "species_10335988", "catalyst" ] ], "additional_components": [ "ENSXETG00000034253" ] }, "reaction_10335379": { "compartment": "compartment_876", "id": "reaction_10335379", "reactome": "R-XTR-8858252", "name": "HDLBP binds HDL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316656", "species_10335375" ], "products": [ "species_10335377" ], "modifiers": [], "additional_components": [ "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "species_171142", "species_216762", "ENSXETG00000012164", "A0A6I8S7E7", "ENSXETG00000012164", "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "species_171142", "species_216762" ] }, "reaction_10317284": { "compartment": "compartment_17947", "id": "reaction_10317284", "reactome": "R-XTR-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_382577" ], "products": [ "species_382571", "species_29372", "species_29370" ], "modifiers": [ [ "species_10317281", "catalyst" ] ], "additional_components": [ "A0A6I8Q353", "ENSXETG00000007705" ] }, "reaction_10322479": { "compartment": "compartment_17906", "id": "reaction_10322479", "reactome": "R-XTR-1369065", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1369066", "species_29356", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1369027" ], "modifiers": [ [ "species_10322476", "catalyst" ] ], "additional_components": [ "Q08D64", "ENSXETT00000030397" ] }, "reaction_10318119": { "compartment": "compartment_876", "id": "reaction_10318119", "reactome": "R-XTR-429094", "name": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10318116", "catalyst" ] ], "additional_components": [ "ENSXETT00000007515" ] }, "reaction_10335959": { "compartment": "compartment_70101", "id": "reaction_10335959", "reactome": "R-XTR-8876319", "name": "SLC50A1 transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10335956", "catalyst" ] ], "additional_components": [ "ENSXETG00000019427" ] }, "reaction_10318099": { "compartment": "compartment_876", "id": "reaction_10318099", "reactome": "R-XTR-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10318096", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_70113", "species_29532", "ENSXETT00000048392" ] }, "reaction_10318281": { "compartment": "compartment_876", "id": "reaction_10318281", "reactome": "R-XTR-442368", "name": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71067" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10318278", "catalyst" ] ], "additional_components": [ "A0A6I8SBF5", "ENSXETG00000041263", "CHEBI:28694", "F7EFD4", "ENSXETT00000006578" ] }, "reaction_10318333": { "compartment": "compartment_876", "id": "reaction_10318333", "reactome": "R-XTR-444160", "name": "VMAT1/2 can mediate the transport of biogenic amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444154" ], "products": [ "species_444152" ], "modifiers": [ [ "species_10318330", "catalyst" ] ], "additional_components": [ "species_351601", "CHEBI:28918", "species_114523", "species_390899", "CHEBI:18357", "CHEBI:18357", "CHEBI:28918", "species_390899", "species_351601", "species_114523", "F6YMA0", "ENSXETT00000019549", "A0A6I8R508", "ENSXETG00000038313" ] }, "reaction_10318203": { "compartment": "compartment_876", "id": "reaction_10318203", "reactome": "R-XTR-434650", "name": "MATEs mediate extrusion of xenobiotics", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_446589" ], "products": [ "species_70106", "species_446597" ], "modifiers": [ [ "species_10318200", "catalyst" ] ], "additional_components": [ "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:6801", "CHEBI:16737", "CHEBI:8428", "CHEBI:42820", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "CHEBI:6801", "A4IIS8", "ENSXETG00000022931", "A0A6I8STL3", "ENSXETG00000039254" ] }, "reaction_10319068": { "compartment": "compartment_876", "id": "reaction_10319068", "reactome": "R-XTR-561253", "name": "SLC22A12 exchanges extracellular urate for cytosolic LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_429056" ], "products": [ "species_373863", "species_30034" ], "modifiers": [ [ "species_10319065", "catalyst" ] ], "additional_components": [ "ENSXETG00000023239" ] }, "reaction_10319063": { "compartment": "compartment_876", "id": "reaction_10319063", "reactome": "R-XTR-561059", "name": "OAT2 and OAT4 mediate transport of sulphate conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561071" ], "products": [ "species_561062", "species_561075" ], "modifiers": [ [ "species_10319060", "catalyst" ] ], "additional_components": [ "species_176496", "species_176501", "species_176501", "species_176496", "ENSXETG00000023239" ] }, "reaction_10319058": { "compartment": "compartment_876", "id": "reaction_10319058", "reactome": "R-XTR-561041", "name": "OAT1-3 transport organic anions with antiport of dicarboxylic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561049" ], "products": [ "species_561078", "species_561075" ], "modifiers": [ [ "species_10319055", "catalyst" ] ], "additional_components": [ "CHEBI:104011", "CHEBI:2453", "CHEBI:2453", "CHEBI:104011", "A0A6I8QMN4", "ENSXETG00000035704", "A0A6I8RMY7", "ENSXETG00000023239" ] }, "reaction_10318169": { "compartment": "compartment_876", "id": "reaction_10318169", "reactome": "R-XTR-433099", "name": "NaS2 co-transports sulphate and two sodium ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_83910", "species_174375" ], "modifiers": [ [ "species_10318166", "catalyst" ] ], "additional_components": [ "ENSXETG00000010608" ] }, "reaction_10320605": { "compartment": "compartment_947586", "id": "reaction_10320605", "reactome": "R-XTR-917839", "name": "apo-Transferrin dissociates from the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320599" ], "products": [ "species_10318912", "species_10320572" ], "modifiers": [], "additional_components": [ "A0A6I8QZE2", "ENSXETG00000040690", "Q501K5", "ENSXETG00000011814", "ENSXETG00000011814", "A0A6I8QZE2", "ENSXETG00000040690" ] }, "reaction_10320588": { "compartment": "compartment_876", "id": "reaction_10320588", "reactome": "R-XTR-917807", "name": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320576" ], "products": [ "species_10320586" ], "modifiers": [], "additional_components": [ "A0A6I8QZE2", "ENSXETG00000040690", "species_912516", "Q501K5", "ENSXETG00000011814", "species_912516", "Q501K5", "ENSXETG00000011814", "A0A6I8QZE2", "ENSXETG00000040690" ] }, "reaction_10320601": { "compartment": "compartment_70101", "id": "reaction_10320601", "reactome": "R-XTR-917814", "name": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320597" ], "products": [ "species_10320599" ], "modifiers": [], "additional_components": [ "A0A6I8QZE2", "ENSXETG00000040690", "Q501K5", "ENSXETG00000011814", "A0A6I8QZE2", "ENSXETG00000040690", "Q501K5", "ENSXETG00000011814" ] }, "reaction_10320603": { "compartment": "compartment_171907", "id": "reaction_10320603", "reactome": "R-XTR-917835", "name": "Fe3+ dissociates from holoTF:TFRC dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320586" ], "products": [ "species_10320597", "species_917966" ], "modifiers": [], "additional_components": [ "species_912516", "Q501K5", "ENSXETG00000011814", "A0A6I8QZE2", "ENSXETG00000040690", "A0A6I8QZE2", "ENSXETG00000040690", "Q501K5", "ENSXETG00000011814" ] }, "reaction_10320612": { "compartment": "compartment_984", "id": "reaction_10320612", "reactome": "R-XTR-917987", "name": "TFRC dimer binds 2xholoTF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320574", "species_10320572" ], "products": [ "species_10320576" ], "modifiers": [], "additional_components": [ "species_912516", "Q501K5", "ENSXETG00000011814", "A0A6I8QZE2", "ENSXETG00000040690", "A0A6I8QZE2", "ENSXETG00000040690", "species_912516", "Q501K5", "ENSXETG00000011814" ] }, "reaction_10331142": { "compartment": "compartment_876", "id": "reaction_10331142", "reactome": "R-XTR-5691154", "name": "HFE binds TFRC dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331138", "species_10320572" ], "products": [ "species_10331140" ], "modifiers": [], "additional_components": [ "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8QZE2", "ENSXETG00000040690", "A0A6I8QZE2", "ENSXETG00000040690", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8PKL5", "ENSXETG00000033834" ] }, "reaction_10320595": { "compartment": "compartment_171907", "id": "reaction_10320595", "reactome": "R-XTR-917811", "name": "STEAP3-like proteins reduce Fe3+ to Fe2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917882", "species_917966" ], "products": [ "species_917810" ], "modifiers": [ [ "species_10320592", "catalyst" ] ], "additional_components": [ "ENSXETT00000016208" ] }, "reaction_10331101": { "compartment": "compartment_70101", "id": "reaction_10331101", "reactome": "R-XTR-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690881", "species_10331097" ], "products": [ "species_10331099" ], "modifiers": [], "additional_components": [ "ENSXETG00000009184", "A0A6I8SX09", "ENSXETG00000009184" ] }, "reaction_10331117": { "compartment": "compartment_5460", "id": "reaction_10331117", "reactome": "R-XTR-5691107", "name": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113531", "species_113529" ], "products": [ "species_5691135" ], "modifiers": [ [ "species_10331114", "catalyst" ] ], "additional_components": [ "F6T7W4", "ENSXETT00000045926" ] }, "reaction_10320607": { "compartment": "compartment_984", "id": "reaction_10320607", "reactome": "R-XTR-917888", "name": "apoTF binds 2Fe3+ to form holoTF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318912", "species_912516" ], "products": [ "species_10320574" ], "modifiers": [], "additional_components": [ "ENSXETG00000011814", "species_912516", "Q501K5", "ENSXETG00000011814" ] }, "reaction_10320566": { "compartment": "compartment_984", "id": "reaction_10320566", "reactome": "R-XTR-917805", "name": "CYBRD1:Heme reduces Fe3+ to Fe2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917828", "species_912516" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10320563", "catalyst" ] ], "additional_components": [ "species_189444", "Q5CZL8", "ENSXETT00000040828" ] }, "reaction_10331110": { "compartment": "compartment_70101", "id": "reaction_10331110", "reactome": "R-XTR-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10331099", "catalyst" ] ], "additional_components": [ "A0A6I8SX09", "ENSXETG00000009184" ] }, "reaction_10320610": { "compartment": "compartment_947586", "id": "reaction_10320610", "reactome": "R-XTR-917933", "name": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347", "species_352327" ], "products": [ "species_109276", "species_912516" ], "modifiers": [ [ "species_10318278", "catalyst" ] ], "additional_components": [ "A0A6I8SBF5", "ENSXETG00000041263", "CHEBI:28694", "F7EFD4", "ENSXETT00000006578" ] }, "reaction_10323458": { "compartment": "compartment_70101", "id": "reaction_10323458", "reactome": "R-XTR-1562626", "name": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71067", "species_29368" ], "products": [ "species_5691103" ], "modifiers": [ [ "species_10323455", "catalyst" ] ], "additional_components": [ "F6T7W4", "ENSXETT00000045926" ] }, "reaction_10320671": { "compartment": "compartment_876", "id": "reaction_10320671", "reactome": "R-XTR-936897", "name": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_29356", "species_113592", "species_83910" ], "products": [ "species_29372", "species_29804", "species_29370", "species_74113" ], "modifiers": [ [ "species_10320666", "catalyst" ], [ "species_10320669", "inhibitor" ] ], "additional_components": [ "Q6P617", "ENSXETT00000095333", "A0A6I8QKL0", "ENSXETG00000020366", "A0A6I8S802", "ENSXETG00000038243", "Q6P617", "ENSXETT00000095333", "A0A6I8QKL0", "ENSXETG00000020366", "A0A6I8S802", "ENSXETG00000038243" ] }, "reaction_10338110": { "compartment": "compartment_984", "id": "reaction_10338110", "reactome": "R-XTR-9684068", "name": "ATP1A:ATP1B:FXYD binds cardiac glycosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9684063", "species_10320666" ], "products": [ "species_10320669" ], "modifiers": [], "additional_components": [ "Q6P617", "ENSXETT00000095333", "A0A6I8QKL0", "ENSXETG00000020366", "A0A6I8S802", "ENSXETG00000038243", "Q6P617", "ENSXETT00000095333", "A0A6I8QKL0", "ENSXETG00000020366", "A0A6I8S802", "ENSXETG00000038243" ] }, "reaction_10329512": { "compartment": "compartment_70101", "id": "reaction_10329512", "reactome": "R-XTR-5251989", "name": "ATP13A4,5 transport divalent ions from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5252122", "species_113592" ], "products": [ "species_29372", "species_29370", "species_5252016" ], "modifiers": [ [ "species_10329509", "catalyst" ] ], "additional_components": [ "F7C820", "ENSXETT00000003028", "A0A6I8R4Z6", "ENSXETG00000034939" ] }, "reaction_10320699": { "compartment": "compartment_876", "id": "reaction_10320699", "reactome": "R-XTR-939763", "name": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_947594" ], "products": [ "species_29372", "species_29370", "species_947588" ], "modifiers": [ [ "species_10320696", "catalyst" ] ], "additional_components": [ "species_8959490", "species_33625", "species_33625", "species_8959490", "Q5BL50", "ENSXETG00000020878" ] }, "reaction_10318054": { "compartment": "compartment_12045", "id": "reaction_10318054", "reactome": "R-XTR-427910", "name": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_74016" ], "products": [ "species_70106", "species_111875" ], "modifiers": [ [ "species_10318040", "catalyst" ], [ "species_10318052", "catalyst" ], [ "species_10318047", "inhibitor" ] ], "additional_components": [ "A0A6I8RIR9", "ENSXETG00000009695", "A0A6I8Q1N1", "ENSXETG00000002512", "A0A6I8ST89", "ENSXETG00000036412", "A0A6I8ST89", "ENSXETG00000036412" ] }, "reaction_10329566": { "compartment": "compartment_70101", "id": "reaction_10329566", "reactome": "R-XTR-5336466", "name": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29926" ], "products": [ "species_109496" ], "modifiers": [ [ "species_10329563", "catalyst" ] ], "additional_components": [ "ENSXETG00000021985" ] }, "reaction_10337028": { "compartment": "compartment_70101", "id": "reaction_10337028", "reactome": "R-XTR-8981621", "name": "Neuroglobin:oxygen dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337024" ], "products": [ "species_29368", "species_10337022" ], "modifiers": [], "additional_components": [ "species_189444", "Q575T7", "ENSXETT00000083304", "species_113533", "species_189444", "Q575T7", "ENSXETT00000083304" ] }, "reaction_10337063": { "compartment": "compartment_70101", "id": "reaction_10337063", "reactome": "R-XTR-8982617", "name": "CYGB:O2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329583" ], "products": [ "species_29368", "species_10329581" ], "modifiers": [], "additional_components": [ "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_113533", "species_189444", "Q6DEW1", "ENSXETT00000093870" ] }, "reaction_10337026": { "compartment": "compartment_70101", "id": "reaction_10337026", "reactome": "R-XTR-8981610", "name": "Neuroglobin binds oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_10337022" ], "products": [ "species_10337024" ], "modifiers": [], "additional_components": [ "species_189444", "Q575T7", "ENSXETT00000083304", "species_189444", "Q575T7", "ENSXETT00000083304", "species_113533" ] }, "reaction_10329738": { "compartment": "compartment_70101", "id": "reaction_10329738", "reactome": "R-XTR-5577050", "name": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10329735", "catalyst" ] ], "additional_components": [ "A0A6I8SN44", "ENSXETG00000041349", "A0A6I8Q2V9", "ENSXETG00000032386", "A0A6I8SMY0", "ENSXETG00000003440", "A0A6I8Q0D6", "ENSXETG00000034068" ] }, "reaction_10329869": { "compartment": "compartment_70101", "id": "reaction_10329869", "reactome": "R-XTR-5615668", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10314206", "catalyst" ] ], "additional_components": [ "A0A6I8R8Y6", "ENSXETG00000040684", "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10329660": { "compartment": "compartment_70101", "id": "reaction_10329660", "reactome": "R-XTR-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10329657", "catalyst" ] ], "additional_components": [ "A0A6I8RYK1", "ENSXETG00000032351", "species_29426", "F6YU63", "ENSXETT00000024409", "F7DZV1", "ENSXETT00000020485", "A0A6I8PVR9", "ENSXETG00000032433" ] }, "reaction_10329646": { "compartment": "compartment_70101", "id": "reaction_10329646", "reactome": "R-XTR-5362518", "name": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10329643", "catalyst" ] ], "additional_components": [ "A0A6I8PYC1", "ENSXETG00000033315", "Q5XGF7", "ENSXETT00000025854", "A8WGW3", "ENSXETT00000002941", "F6Z4N6", "ENSXETT00000035399" ] }, "reaction_10329909": { "compartment": "compartment_70101", "id": "reaction_10329909", "reactome": "R-XTR-5622134", "name": "CRABP1 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329651", "species_5334816" ], "products": [ "species_10329653" ], "modifiers": [], "additional_components": [ "ENSXETG00000040354", "species_215573", "A0A6I8QHI5", "ENSXETG00000040354" ] }, "reaction_10329655": { "compartment": "compartment_70101", "id": "reaction_10329655", "reactome": "R-XTR-5362525", "name": "CYP26A1,B1,C1 4-hydroxylate atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_10329653", "species_29364" ], "products": [ "species_10329651", "species_29356", "species_5362521", "species_29366" ], "modifiers": [ [ "species_10316440", "catalyst" ] ], "additional_components": [ "species_215573", "A0A6I8QHI5", "ENSXETG00000040354", "ENSXETG00000040354", "ENSXETG00000021546" ] }, "reaction_10332441": { "compartment": "compartment_876", "id": "reaction_10332441", "reactome": "R-XTR-6794346", "name": "NRXNs bind NLGNs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10332437", "species_10332431" ], "products": [ "species_10332439" ], "modifiers": [], "additional_components": [ "A0A6I8S9J2", "ENSXETG00000035941", "ENSXETG00000011090", "A0A6I8Q952", "ENSXETG00000011090", "A0A6I8S9J2", "ENSXETG00000035941" ] }, "reaction_10332482": { "compartment": "compartment_876", "id": "reaction_10332482", "reactome": "R-XTR-6797974", "name": "LRRTMs bind NRXNs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10332478", "species_10332431" ], "products": [ "species_10332480" ], "modifiers": [], "additional_components": [ "ENSXETG00000011090", "A0A6I8Q952", "ENSXETG00000011090" ] }, "reaction_10313806": { "compartment": "compartment_17963", "id": "reaction_10313806", "reactome": "R-XTR-177107", "name": "Secretion and activation of the latent large complex of TGF-beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313438" ], "products": [ "species_10313444" ], "modifiers": [], "additional_components": [ "F6SX40", "ENSXETT00000046545", "F6SX40", "ENSXETT00000046545" ] }, "reaction_10313440": { "compartment": "compartment_20699", "id": "reaction_10313440", "reactome": "R-XTR-170844", "name": "Latent TGF-beta-1 is cleaved by furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313434" ], "products": [ "species_10313438" ], "modifiers": [ [ "species_10313057", "catalyst" ] ], "additional_components": [ "F6SX40", "ENSXETT00000046545", "F6SX40", "ENSXETT00000046545", "ENSXETG00000015462" ] }, "reaction_10334815": { "compartment": "compartment_984", "id": "reaction_10334815", "reactome": "R-XTR-8849857", "name": "KLK5 cleaves and activates CELA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10334808" ], "products": [ "species_10334810", "species_10334812" ], "modifiers": [ [ "species_10334804", "catalyst" ] ], "additional_components": [ "ENSXETT00000031018", "ENSXETT00000031018", "ENSXETT00000031018", "ENSXETT00000037000" ] }, "reaction_10334837": { "compartment": "compartment_984", "id": "reaction_10334837", "reactome": "R-XTR-8850831", "name": "KLK5 cleaves and activates KLK8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10334831" ], "products": [ "species_10334835", "species_10334833" ], "modifiers": [ [ "species_10334804", "catalyst" ] ], "additional_components": [ "ENSXETT00000037000", "ENSXETT00000037000", "ENSXETT00000037000", "ENSXETT00000037000" ] }, "reaction_10332400": { "compartment": "compartment_984", "id": "reaction_10332400", "reactome": "R-XTR-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174675", "species_6789319" ], "modifiers": [ [ "species_10332391", "catalyst" ] ], "additional_components": [ "ENSXETT00000020371" ] }, "reaction_10312850": { "compartment": "compartment_876", "id": "reaction_10312850", "reactome": "R-XTR-140761", "name": "sequestered tissue factor -> tissue factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312848" ], "products": [ "species_10312846" ], "modifiers": [], "additional_components": [ "ENSXETG00000030465", "ENSXETG00000030465" ] }, "reaction_10322381": { "compartment": "compartment_984", "id": "reaction_10322381", "reactome": "R-XTR-1297333", "name": "Association of Acrosin Heavy and Light Chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322369", "species_10322377" ], "products": [ "species_10322379" ], "modifiers": [], "additional_components": [ "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8R444", "ENSXETG00000036832", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8R444", "ENSXETG00000036832", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8R444", "ENSXETG00000036832" ] }, "reaction_10322392": { "compartment": "compartment_984", "id": "reaction_10322392", "reactome": "R-XTR-1297354", "name": "Acrosin Cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322389" ], "products": [ "species_10322369", "species_10322377" ], "modifiers": [ [ "species_10322389", "catalyst" ] ], "additional_components": [ "A0A6I8R444", "ENSXETG00000036832", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8R444", "ENSXETG00000036832", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8R444", "ENSXETG00000036832", "A0A6I8R444", "ENSXETG00000036832", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8SN95", "ENSXETG00000034074" ] }, "reaction_10328392": { "compartment": "compartment_70101", "id": "reaction_10328392", "reactome": "R-XTR-3965450", "name": "DAAM1 recruits PFN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315909", "species_10328315" ], "products": [ "species_10328390" ], "modifiers": [], "additional_components": [ "ENSXETG00000036913", "A0A6I8SJ25", "ENSXETG00000017030", "Q05AS8", "ENSXETG00000017212", "A0A6I8SJ25", "ENSXETG00000017030", "Q05AS8", "ENSXETG00000017212", "A0A6I8RDQ2", "ENSXETG00000036913" ] }, "reaction_10328309": { "compartment": "compartment_876", "id": "reaction_10328309", "reactome": "R-XTR-3858482", "name": "DVL is recruited to the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328305", "species_10328303" ], "products": [ "species_10328307" ], "modifiers": [], "additional_components": [ "Q05AS8", "ENSXETG00000017212", "B2GUT4", "ENSXETT00000042046", "Q5BL72", "ENSXETT00000027115", "B2GUT4", "ENSXETT00000042046", "Q5BL72", "ENSXETT00000027115", "Q05AS8", "ENSXETG00000017212" ] }, "reaction_10328295": { "compartment": "compartment_70101", "id": "reaction_10328295", "reactome": "R-XTR-3858475", "name": "ppDVL recruits RAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328291", "species_10318239" ], "products": [ "species_10328293" ], "modifiers": [], "additional_components": [ "Q05AS8", "ENSXETG00000017212", "F7DEH8", "ENSXETT00000009928", "Q6GL60", "ENSXETT00000092508", "species_29438", "F7DEH8", "ENSXETT00000009928", "Q6GL60", "ENSXETT00000092508", "species_29438", "Q05AS8", "ENSXETG00000017212" ] }, "reaction_10316717": { "compartment": "compartment_70101", "id": "reaction_10316717", "reactome": "R-XTR-351863", "name": "Translocation of active caspase-8 to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316682" ], "products": [ "species_10316715" ], "modifiers": [], "additional_components": [ "A0A6I8Q0P2", "ENSXETG00000032748", "A0A6I8Q0P2", "ENSXETG00000032748" ] }, "reaction_10335361": { "compartment": "compartment_7660", "id": "reaction_10335361", "reactome": "R-XTR-8857692", "name": "RNA demethylases demethylate N6-methyladenosine RNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8857725", "species_113671", "species_111793" ], "products": [ "species_8857850", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10335358", "catalyst" ] ], "additional_components": [ "species_435347", "F6U6S7", "ENSXETT00000012796", "Q66JG8", "ENSXETT00000012702" ] }, "reaction_10337796": { "compartment": "compartment_7660", "id": "reaction_10337796", "reactome": "R-XTR-9624120", "name": "CEBPA binds CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311327", "species_10337788" ], "products": [ "species_10337794" ], "modifiers": [], "additional_components": [ "ENSXETT00000046130", "ENSXETG00000039574", "A0A6I8R9D5", "ENSXETG00000039574", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10337792": { "compartment": "compartment_7660", "id": "reaction_10337792", "reactome": "R-XTR-9624112", "name": "CEBPA binds CDK4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337784", "species_10337788" ], "products": [ "species_10337790" ], "modifiers": [], "additional_components": [ "ENSXETG00000035239", "ENSXETG00000039574", "A0A6I8R9D5", "ENSXETG00000039574", "A0A6I8R6Z7", "ENSXETG00000035239" ] }, "reaction_10334445": { "compartment": "compartment_70101", "id": "reaction_10334445", "reactome": "R-XTR-6806613", "name": "Keratin tetramers bind to form unit length filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334433" ], "products": [ "species_10334437" ], "modifiers": [], "additional_components": [ "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390" ] }, "reaction_10334431": { "compartment": "compartment_70101", "id": "reaction_10334431", "reactome": "R-XTR-6805546", "name": "Keratin type I binds keratin type II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334213", "species_10334427" ], "products": [ "species_10334429" ], "modifiers": [], "additional_components": [ "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390" ] }, "reaction_10334443": { "compartment": "compartment_70101", "id": "reaction_10334443", "reactome": "R-XTR-6806610", "name": "Keratin filament formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334439" ], "products": [ "species_10334441" ], "modifiers": [], "additional_components": [ "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390" ] }, "reaction_10334449": { "compartment": "compartment_70101", "id": "reaction_10334449", "reactome": "R-XTR-6806629", "name": "Formation of tonofilament bundles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334441" ], "products": [ "species_10334447" ], "modifiers": [], "additional_components": [ "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390" ] }, "reaction_10334435": { "compartment": "compartment_70101", "id": "reaction_10334435", "reactome": "R-XTR-6805573", "name": "Keratin type I/type II heterodimers form tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334429" ], "products": [ "species_10334433" ], "modifiers": [], "additional_components": [ "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390" ] }, "reaction_10331235": { "compartment": "compartment_876", "id": "reaction_10331235", "reactome": "R-XTR-5692408", "name": "NPR2 binds NPPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331227", "species_10331231" ], "products": [ "species_10331233" ], "modifiers": [], "additional_components": [ "ENSXETG00000041083", "ENSXETG00000031971", "A0A6I8SDR4", "ENSXETG00000031971", "A0A6I8SMD0", "ENSXETG00000041083" ] }, "reaction_10329753": { "compartment": "compartment_70101", "id": "reaction_10329753", "reactome": "R-XTR-5578777", "name": "DMPK phosphorylates PLN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10318047" ], "products": [ "species_29370", "species_10318052" ], "modifiers": [ [ "species_10329750", "catalyst" ] ], "additional_components": [ "A0A6I8ST89", "ENSXETG00000036412", "A0A6I8ST89", "ENSXETG00000036412", "F6V346", "ENSXETT00000036273" ] }, "reaction_10329776": { "compartment": "compartment_70101", "id": "reaction_10329776", "reactome": "R-XTR-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10329773", "catalyst" ] ], "additional_components": [ "F6WH56", "ENSXETT00000048965", "F7AEN8", "ENSXETT00000009094" ] }, "reaction_10312747": { "compartment": "compartment_70101", "id": "reaction_10312747", "reactome": "R-XTR-114553", "name": "Activation of conventional Protein Kinase C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_10312735", "species_74016" ], "products": [ "species_10312745" ], "modifiers": [ [ "species_114519", "catalyst" ] ], "additional_components": [ "ENSXETG00000017294", "species_114519", "species_33625", "species_74112", "A8KBH6", "ENSXETG00000017294" ] }, "reaction_10318808": { "compartment": "compartment_876", "id": "reaction_10318808", "reactome": "R-XTR-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318758" ], "products": [ "species_10318806" ], "modifiers": [], "additional_components": [ "A0A6I8QDT0", "ENSXETG00000039678", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8S6I0", "ENSXETG00000027692", "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942", "A0A6I8QL92", "ENSXETG00000039008", "F6SYS3", "ENSXETT00000046350", "A0A6I8S033", "ENSXETG00000009423", "A0A6I8PY35", "ENSXETG00000033269", "F7B6V1", "ENSXETT00000038623", "A0A6I8Q251", "ENSXETG00000030791", "F7D5C5", "ENSXETT00000001620", "F6TMK5", "ENSXETT00000046700", "F7CZB7", "ENSXETT00000006287", "A0A6I8PVG7", "ENSXETG00000031284", "A0A6I8Q0D7", "ENSXETG00000032630", "F7C1U1", "ENSXETT00000043296", "Q5BKJ7", "ENSXETT00000050639", "A0A6I8SC83", "ENSXETG00000038196", "F6SX40", "ENSXETT00000046545", "A0A6I8STH4", "ENSXETG00000035410", "F6YIE1", "ENSXETT00000016028", "Q6P326", "ENSXETG00000021646", "Q66JG0", "ENSXETG00000008500", "F7CWY4", "ENSXETT00000011877", "F7CZB7", "ENSXETT00000006287", "A0A6I8S6I0", "ENSXETG00000027692", "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942", "Q66JG0", "ENSXETG00000008500", "Q5BKJ7", "ENSXETT00000050639", "F7B6V1", "ENSXETT00000038623", "A0A6I8PY35", "ENSXETG00000033269", "A0A6I8QDT0", "ENSXETG00000039678", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8S033", "ENSXETG00000009423", "F7D5C5", "ENSXETT00000001620", "A0A6I8STH4", "ENSXETG00000035410", "A0A6I8Q0D7", "ENSXETG00000032630", "F6SYS3", "ENSXETT00000046350", "A0A6I8QL92", "ENSXETG00000039008", "F7CWY4", "ENSXETT00000011877", "F6YIE1", "ENSXETT00000016028", "Q6P326", "ENSXETG00000021646", "F6TMK5", "ENSXETT00000046700", "F7C1U1", "ENSXETT00000043296", "A0A6I8SC83", "ENSXETG00000038196", "A0A6I8Q251", "ENSXETG00000030791", "A0A6I8PVG7", "ENSXETG00000031284", "F6SX40", "ENSXETT00000046545" ] }, "reaction_10318868": { "compartment": "compartment_876", "id": "reaction_10318868", "reactome": "R-XTR-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318842" ], "products": [ "species_10318866" ], "modifiers": [], "additional_components": [ "species_29438", "species_29370", "B0BLS9", "ENSXETT00000049183", "species_109496", "Q28F45", "ENSXETT00000055303", "species_113593", "Q28HY7", "ENSXETG00000000595", "species_29372", "A0A6I8RL39", "ENSXETG00000006887", "A0A6I8SSC0", "ENSXETG00000036712", "species_74112", "species_114523", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350", "A0A6I8QL92", "ENSXETG00000039008", "species_29420", "species_159450", "species_74112", "species_29438", "species_29370", "species_159450", "species_109496", "species_113593", "A0A6I8RL39", "ENSXETG00000006887", "A0A6I8SSC0", "ENSXETG00000036712", "B0BLS9", "ENSXETT00000049183", "Q28HY7", "ENSXETG00000000595", "species_114523", "Q28F45", "ENSXETT00000055303", "species_29372", "species_29420", "A0A6I8QL92", "ENSXETG00000039008", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350" ] }, "reaction_10318948": { "compartment": "compartment_70101", "id": "reaction_10318948", "reactome": "R-XTR-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318936" ], "products": [ "species_10318946" ], "modifiers": [], "additional_components": [ "Q6DIF4", "ENSXETG00000000629", "Q28IX8", "ENSXETG00000019288", "A0A6I8RS05", "ENSXETG00000036422", "Q0IIW3", "ENSXETT00000015994", "Q6DIF4", "ENSXETG00000000629", "Q0IIW3", "ENSXETT00000015994", "Q28IX8", "ENSXETG00000019288", "A0A6I8RS05", "ENSXETG00000036422" ] }, "reaction_10318918": { "compartment": "compartment_984", "id": "reaction_10318918", "reactome": "R-XTR-482770", "name": "Release of platelet secretory granule components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318910" ], "products": [ "species_10318916" ], "modifiers": [], "additional_components": [ "F7E728", "ENSXETG00000020755", "A0A6I8PU04", "ENSXETG00000033423", "Q501K5", "ENSXETG00000011814", "A0A6I8PU04", "ENSXETG00000033423", "Q501K5", "ENSXETG00000011814", "F7E728", "ENSXETG00000020755" ] }, "reaction_10316707": { "compartment": "compartment_161320", "id": "reaction_10316707", "reactome": "R-XTR-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316703" ], "products": [ "species_10316705" ], "modifiers": [], "additional_components": [ "ENSXETT00000041328", "ENSXETT00000041328" ] }, "reaction_10318882": { "compartment": "compartment_876", "id": "reaction_10318882", "reactome": "R-XTR-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318876" ], "products": [ "species_10318880" ], "modifiers": [], "additional_components": [ "A0A6I8SL99", "ENSXETG00000003366", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8SL99", "ENSXETG00000003366", "A0A6I8SFE9", "ENSXETG00000039556" ] }, "reaction_10318898": { "compartment": "compartment_876", "id": "reaction_10318898", "reactome": "R-XTR-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318892" ], "products": [ "species_10318896" ], "modifiers": [], "additional_components": [ "A0A6I8Q083", "ENSXETG00000031004", "A0A6I8S279", "ENSXETG00000037724", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8Q083", "ENSXETG00000031004", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8S279", "ENSXETG00000037724" ] }, "reaction_10318249": { "compartment": "compartment_70101", "id": "reaction_10318249", "reactome": "R-XTR-442273", "name": "VAV1 is a GEF for Rho/Rac family GTPases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10318237" ], "products": [ "species_29420", "species_10318239" ], "modifiers": [ [ "species_10318242", "catalyst" ], [ "species_10318247", "catalyst" ], [ "species_10318245", "inhibitor" ] ], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "Q6GL60", "ENSXETT00000092508", "species_29420", "F7DEH8", "ENSXETT00000009928", "Q6GL60", "ENSXETT00000092508", "species_29438", "ENSXETT00000043225", "species_179838", "L7N3Q8", "ENSXETT00000043225", "species_179856", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10318123": { "compartment": "compartment_876", "id": "reaction_10318123", "reactome": "R-XTR-429497", "name": "SLP-76 stimulates PLC gamma 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318121" ], "products": [ "species_10312756" ], "modifiers": [], "additional_components": [ "ENSXETG00000003578", "ENSXETG00000003578" ] }, "reaction_10312759": { "compartment": "compartment_70101", "id": "reaction_10312759", "reactome": "R-XTR-114689", "name": "PLC gamma 2-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10312756", "catalyst" ] ], "additional_components": [ "ENSXETG00000003578" ] }, "reaction_10322394": { "compartment": "compartment_876", "id": "reaction_10322394", "reactome": "R-XTR-1297444", "name": "Binding of cAMP to HCN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322341", "species_30389" ], "products": [ "species_10322343" ], "modifiers": [], "additional_components": [ "A0A6I8SMA9", "ENSXETG00000017714", "A0A6I8RXX5", "ENSXETG00000031566", "species_30389", "A0A6I8SMA9", "ENSXETG00000017714", "A0A6I8RXX5", "ENSXETG00000031566" ] }, "reaction_10322346": { "compartment": "compartment_876", "id": "reaction_10322346", "reactome": "R-XTR-1296043", "name": "Activation of HCN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10322343", "catalyst" ] ], "additional_components": [ "species_30389", "A0A6I8SMA9", "ENSXETG00000017714", "A0A6I8RXX5", "ENSXETG00000031566" ] }, "reaction_10317036": { "compartment": "compartment_204883", "id": "reaction_10317036", "reactome": "R-XTR-375342", "name": "Connexin 36 mediated neuronal gap junction communication", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_29804" ], "modifiers": [ [ "species_10317033", "catalyst" ] ], "additional_components": [ "A0A6I8RRX1", "ENSXETG00000038711" ] }, "reaction_10311663": { "compartment": "compartment_876", "id": "reaction_10311663", "reactome": "R-XTR-71050", "name": "Trimerization of the FASL:FAS receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311659" ], "products": [ "species_10311661" ], "modifiers": [], "additional_components": [ "A0A6I8PTW1", "ENSXETG00000031916", "A0A6I8QWZ8", "ENSXETG00000041356", "A0A6I8PTW1", "ENSXETG00000031916", "A0A6I8QWZ8", "ENSXETG00000041356" ] }, "reaction_10312086": { "compartment": "compartment_876", "id": "reaction_10312086", "reactome": "R-XTR-75244", "name": "FASL binds FAS Receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311653", "species_10311657" ], "products": [ "species_10311659" ], "modifiers": [], "additional_components": [ "ENSXETG00000041356", "ENSXETG00000031916", "A0A6I8PTW1", "ENSXETG00000031916", "A0A6I8QWZ8", "ENSXETG00000041356" ] }, "reaction_10312879": { "compartment": "compartment_984", "id": "reaction_10312879", "reactome": "R-XTR-140847", "name": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312839", "species_74112" ], "products": [ "species_10312833", "species_10312877" ], "modifiers": [], "additional_components": [ "F6YIE1", "ENSXETT00000016028", "A0A6I8PQF3", "ENSXETG00000031728", "ENSXETG00000031728", "species_74112", "F6YIE1", "ENSXETT00000016028" ] }, "reaction_10326879": { "compartment": "compartment_876", "id": "reaction_10326879", "reactome": "R-XTR-2534378", "name": "Hv1 Mediated H+ Permeability", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1132304" ], "products": [ "species_351626" ], "modifiers": [ [ "species_10326876", "catalyst" ] ], "additional_components": [ "Q5M8L8", "ENSXETT00000045238" ] }, "reaction_10326870": { "compartment": "compartment_876", "id": "reaction_10326870", "reactome": "R-XTR-2534346", "name": "SPAM1 Binds Hyaluronic Acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326866", "species_1297302" ], "products": [ "species_10326868" ], "modifiers": [], "additional_components": [ "ENSXETG00000033261", "species_1297302", "A0A6I8PVK0", "ENSXETG00000033261" ] }, "reaction_10330885": { "compartment": "compartment_5460", "id": "reaction_10330885", "reactome": "R-XTR-5688289", "name": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_10330874" ], "products": [ "species_5688337", "species_5688274", "species_10330876" ], "modifiers": [ [ "species_10330882", "catalyst" ] ], "additional_components": [ "F6WI63", "ENSXETT00000017597", "Q5XGI4", "ENSXETT00000103326", "F6WI63", "ENSXETT00000017597", "Q5XGI4", "ENSXETT00000103326", "A0A6I8PP16", "ENSXETG00000032567", "species_29426" ] }, "reaction_10330902": { "compartment": "compartment_17927", "id": "reaction_10330902", "reactome": "R-XTR-5688294", "name": "SIRT5 deacetylates Cytochrome C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5688282", "species_10330893" ], "products": [ "species_5688281", "species_10312698", "species_5688340" ], "modifiers": [ [ "species_10330899", "catalyst" ] ], "additional_components": [ "Q640U4", "ENSXETT00000018532", "Q6PBF4", "ENSXETT00000049267", "Q6PBF4", "ENSXETT00000049267", "Q640U4", "ENSXETT00000018532", "species_29426", "F7DKV7", "ENSXETT00000004834" ] }, "reaction_10335711": { "compartment": "compartment_70101", "id": "reaction_10335711", "reactome": "R-XTR-8865107", "name": "MICAL1 produces NADP+, H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_29366", "species_29408" ], "modifiers": [ [ "species_10335708", "catalyst" ] ], "additional_components": [ "A0A6I8PP59", "ENSXETG00000013342", "species_113596" ] }, "reaction_10321770": { "compartment": "compartment_7660", "id": "reaction_10321770", "reactome": "R-XTR-997263", "name": "JMJD1C demethylates H3K9 mono- and di-methylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321761" ], "products": [ "species_10321763" ], "modifiers": [ [ "species_10321767", "catalyst" ] ], "additional_components": [ "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "ENSXETG00000007684" ] }, "reaction_10321786": { "compartment": "compartment_7660", "id": "reaction_10321786", "reactome": "R-XTR-1008200", "name": "NFE2 binds the beta globin locus control region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1008228", "species_10321782" ], "products": [ "species_10321784" ], "modifiers": [], "additional_components": [ "F7A9R6", "ENSXETT00000041786", "A0A6I8PVX4", "ENSXETG00000027400", "F7A9R6", "ENSXETT00000041786", "A0A6I8PVX4", "ENSXETG00000027400" ] }, "reaction_10321794": { "compartment": "compartment_70101", "id": "reaction_10321794", "reactome": "R-XTR-1011598", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317328", "species_10321790" ], "products": [ "species_10321792" ], "modifiers": [], "additional_components": [ "ENSXETT00000092508", "ENSXETG00000003669", "A0A6I8SJK6", "ENSXETG00000003669", "Q6GL60", "ENSXETT00000092508" ] } }, "motif_reaction_dictionary": { "reaction_10315596": { "compartment": "compartment_876", "id": "reaction_10315596", "reactome": "R-XTR-199576", "name": "KIR3DL2 interacting with HLA-A3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315590", "species_10315592" ], "products": [ "species_10315594" ], "modifiers": [], "additional_components": [ "ENSXETG00000032630", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8Q0D7", "ENSXETG00000032630" ] }, "reaction_10331487": { "compartment": "compartment_876", "id": "reaction_10331487", "reactome": "R-XTR-5696358", "name": "TREM,CD300 binds lipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696348", "species_10331483" ], "products": [ "species_10331485" ], "modifiers": [], "additional_components": [ "species_8959486", "species_33625", "species_8959490", "A0A6I8PSB6", "ENSXETG00000032041", "A0A6I8QSY3", "ENSXETG00000037809", "A0A6I8SNS8", "ENSXETG00000036363", "A0A6I8PSB6", "ENSXETG00000032041", "A0A6I8QSY3", "ENSXETG00000037809", "A0A6I8SNS8", "ENSXETG00000036363", "species_8959486", "species_33625", "species_8959490" ] }, "reaction_10315604": { "compartment": "compartment_876", "id": "reaction_10315604", "reactome": "R-XTR-199579", "name": "KIR2DL4 interacting with HLA-G", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315600", "species_10315598" ], "products": [ "species_10315602" ], "modifiers": [], "additional_components": [ "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8PKK9", "ENSXETG00000033246", "ENSXETG00000032630", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8PKK9", "ENSXETG00000033246" ] }, "reaction_10330788": { "compartment": "compartment_876", "id": "reaction_10330788", "reactome": "R-XTR-5685607", "name": "Sialic acid binds SIGLEC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330784", "species_1006168" ], "products": [ "species_10330786" ], "modifiers": [], "additional_components": [ "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8R800", "ENSXETG00000040970", "species_1006168", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8R800", "ENSXETG00000040970" ] }, "reaction_10314694": { "compartment": "compartment_876", "id": "reaction_10314694", "reactome": "R-XTR-199154", "name": "CD200 binds to CD200R", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314690", "species_10314686" ], "products": [ "species_10314692" ], "modifiers": [], "additional_components": [ "ENSXETG00000034946", "ENSXETG00000039727", "A0A6I8QKB5", "ENSXETG00000039727", "A0A6I8SWZ3", "ENSXETG00000034946" ] }, "reaction_10315536": { "compartment": "compartment_876", "id": "reaction_10315536", "reactome": "R-XTR-199161", "name": "Fc gamma receptors interact with antigen-bound IgG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315514", "species_10315532" ], "products": [ "species_10315534" ], "modifiers": [], "additional_components": [ "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8PWK1", "ENSXETT00000069302", "A0A6I8PXL5", "ENSXETT00000069302", "A0A5G3K4A2", "ENSXETT00000069302", "F7ATU6", "ENSXETT00000069302", "A0A6I8PNW8", "ENSXETT00000069302", "L7N2W1", "ENSXETT00000013311", "A0A6I8SSF0", "ENSXETT00000069302", "A0A6I8SYX6", "ENSXETT00000069302", "A0A6I8SF25", "ENSXETT00000069302", "A0A6I8SJ82", "ENSXETT00000069302", "A0A6I8SCS2", "ENSXETT00000069302", "A0A6I8SCZ9", "ENSXETT00000069302", "A0A6I8S4K2", "ENSXETT00000069302", "A0A6I8S824", "ENSXETT00000069302", "A0A6I8S1H6", "ENSXETT00000069302", "A0A6I8S3H5", "ENSXETT00000069302", "A0A6I8RTG9", "ENSXETT00000069302", "A0A6I8RYE0", "ENSXETT00000069302", "A0A6I8RLS5", "ENSXETT00000069302", "A0A6I8RQ73", "ENSXETT00000069302", "A0A6I8RDF6", "ENSXETT00000069302", 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"ENSXETG00000040383", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212", "A0A6I8SK71", "ENSXETG00000040212", "A0A6I8QZL1", "ENSXETG00000040212", "A0A6I8RUJ4", "ENSXETG00000040212", "A0A6I8QKP4", "ENSXETG00000040212", "A0A6I8RNX1", "ENSXETG00000040212", "A0A6I8SYV6", "ENSXETG00000040212" ] }, "reaction_10315570": { "compartment": "compartment_876", "id": "reaction_10315570", "reactome": "R-XTR-199404", "name": "CD40L binds CD40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315562", "species_10315566" ], "products": [ "species_10315568" ], "modifiers": [], "additional_components": [ "F6WJ69", "ENSXETT00000005335", "A0A6I8PXA6", "ENSXETG00000030595", "F6WJ69", "ENSXETT00000005335", "A0A6I8PXA6", "ENSXETG00000030595" ] }, "reaction_10313549": { "compartment": "compartment_70101", "id": "reaction_10313549", "reactome": "R-XTR-175983", "name": "COMT transfer CH3 from AdoMet to 3,4DHBNZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_175977", "species_71284" ], "products": [ "species_175978", "species_71285" ], "modifiers": [ [ "species_10313546", "catalyst" ] ], "additional_components": [ "ENSXETT00000064849" ] }, "reaction_10313556": { "compartment": "compartment_70101", "id": "reaction_10313556", "reactome": "R-XTR-175987", "name": "NNMT transfers CH3 from AdoMet to PY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_175973", "species_71284" ], "products": [ "species_175979", "species_71285" ], "modifiers": [ [ "species_10313553", "catalyst" ] ], "additional_components": [ "ENSXETG00000028049" ] }, "reaction_10329809": { "compartment": "compartment_70101", "id": "reaction_10329809", "reactome": "R-XTR-5603114", "name": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_174390" ], "products": [ "species_111294", "species_29372", "species_71284" ], "modifiers": [ [ "species_10329806", "catalyst" ] ], "additional_components": [ "species_109496", "F6X2C1", "ENSXETT00000002716", "species_74126", "Q566L8", "ENSXETG00000015071" ] }, "reaction_10312209": { "compartment": "compartment_17960", "id": "reaction_10312209", "reactome": "R-XTR-76386", "name": "CYP1A2 S-demethylates 6MMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_76384", "species_113601" ], "products": [ "species_143501", "species_113519", "species_113564", "species_33153" ], "modifiers": [ [ "species_10312204", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10331414": { "compartment": "compartment_5460", "id": "reaction_10331414", "reactome": "R-XTR-5694563", "name": "ABHD10 hydrolyses MPAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694574", "species_113521" ], "products": [ "species_5694569", "species_5694565" ], "modifiers": [ [ "species_10331411", "catalyst" ] ], "additional_components": [ "ENSXETT00000020196" ] }, "reaction_10313610": { "compartment": "compartment_17957", "id": "reaction_10313610", "reactome": "R-XTR-176059", "name": "GST trimers transfer GS from GSH to luminal substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158543", "species_176065" ], "products": [ "species_176048" ], "modifiers": [ [ "species_10313607", "catalyst" ] ], "additional_components": [ "species_156523", "species_38987", "species_76396", "CHEBI:32639", "CHEBI:2505", "CHEBI:35896", "A0A6I8RJ83", "ENSXETG00000036671", "F6PX96", "ENSXETT00000016673", "F6VC96", "ENSXETT00000010309" ] }, "reaction_10331194": { "compartment": "compartment_70101", "id": "reaction_10331194", "reactome": "R-XTR-5692232", "name": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_5692212" ], "products": [ "species_5692216", "species_29364" ], "modifiers": [ [ "species_10330359", "catalyst" ] ], "additional_components": [ "ENSXETT00000007570" ] }, "reaction_10322294": { "compartment": "compartment_70101", "id": "reaction_10322294", "reactome": "R-XTR-1247922", "name": "GGCT transforms gGluCys to OPRO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393" ], "products": [ "species_111707", "species_1247942" ], "modifiers": [ [ "species_10322291", "catalyst" ] ], "additional_components": [ "F6PKI1", "ENSXETT00000047646" ] }, "reaction_10313587": { "compartment": "compartment_70101", "id": "reaction_10313587", "reactome": "R-XTR-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10313584", "catalyst" ] ], "additional_components": [ "species_76396", "CHEBI:34718", "CHEBI:30614", "CHEBI:8927", "CHEBI:32639", "CHEBI:34479", "A0A6I8S817", "ENSXETG00000036388", "F6SJ37", "ENSXETT00000045440", "A0A6I8QYI0", "ENSXETG00000038870" ] }, "reaction_10331421": { "compartment": "compartment_70101", "id": "reaction_10331421", "reactome": "R-XTR-5695964", "name": "ABHD14B hydrolyses PNPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5695960", "species_29356" ], "products": [ "species_5695950", "species_76179" ], "modifiers": [ [ "species_10331418", "catalyst" ] ], "additional_components": [ "ENSXETT00000063063" ] }, "reaction_10336924": { "compartment": "compartment_17963", "id": "reaction_10336924", "reactome": "R-XTR-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8851226", "species_8953493" ], "modifiers": [ [ "species_10336921", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "species_109496", "Q28CL4", "ENSXETT00000012482" ] }, "reaction_10313663": { "compartment": "compartment_70101", "id": "reaction_10313663", "reactome": "R-XTR-176631", "name": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176626" ], "products": [ "species_176496", "species_158466" ], "modifiers": [ [ "species_10313660", "catalyst" ] ], "additional_components": [ "A0A6I8PTM1", "ENSXETG00000033931", "B0BM84", "ENSXETT00000064929" ] }, "reaction_10313656": { "compartment": "compartment_70101", "id": "reaction_10313656", "reactome": "R-XTR-176604", "name": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176565", "species_158471" ], "products": [ "species_176483", "species_158466" ], "modifiers": [ [ "species_10313634", "catalyst" ] ], "additional_components": [ "B0BM84", "ENSXETT00000064929", "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313658": { "compartment": "compartment_70101", "id": "reaction_10313658", "reactome": "R-XTR-176609", "name": "cholesterol + PAPS => cholesterol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_158471" ], "products": [ "species_176618", "species_158466" ], "modifiers": [ [ "species_10313643", "catalyst" ] ], "additional_components": [ "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313654": { "compartment": "compartment_70101", "id": "reaction_10313654", "reactome": "R-XTR-176588", "name": "lithocholate + PAPS => lithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_158471" ], "products": [ "species_176555", "species_158466" ], "modifiers": [ [ "species_10313634", "catalyst" ] ], "additional_components": [ "B0BM84", "ENSXETT00000064929", "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313649": { "compartment": "compartment_70101", "id": "reaction_10313649", "reactome": "R-XTR-176517", "name": "SULTs transfer (SO4)2- group to PREG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_158471" ], "products": [ "species_176665", "species_158466" ], "modifiers": [ [ "species_10313643", "catalyst" ] ], "additional_components": [ "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313651": { "compartment": "compartment_70101", "id": "reaction_10313651", "reactome": "R-XTR-176585", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176667", "species_158471" ], "products": [ "species_176564", "species_158466" ], "modifiers": [ [ "species_10313636", "catalyst" ] ], "additional_components": [ "F6QKH7", "ENSXETT00000042862", "L7N312", "ENSXETT00000017267", "B0BM84", "ENSXETT00000064929", "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313682": { "compartment": "compartment_70101", "id": "reaction_10313682", "reactome": "R-XTR-176669", "name": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176566" ], "products": [ "species_176500", "species_158466" ], "modifiers": [ [ "species_10313679", "catalyst" ] ], "additional_components": [ "F6QKH7", "ENSXETT00000042862", "L7N312", "ENSXETT00000017267" ] }, "reaction_10313677": { "compartment": "compartment_70101", "id": "reaction_10313677", "reactome": "R-XTR-176664", "name": "estrone + PAPS => estrone 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176575", "species_158471" ], "products": [ "species_176501", "species_158466" ], "modifiers": [ [ "species_10313634", "catalyst" ] ], "additional_components": [ "B0BM84", "ENSXETT00000064929", "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313646": { "compartment": "compartment_70101", "id": "reaction_10313646", "reactome": "R-XTR-176494", "name": "SULTs transfer (SO4)2- group to 27HCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176617", "species_158471" ], "products": [ "species_176502", "species_158466" ], "modifiers": [ [ "species_10313643", "catalyst" ] ], "additional_components": [ "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10336939": { "compartment": "compartment_17963", "id": "reaction_10336939", "reactome": "R-XTR-8954262", "name": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336928", "species_741440" ], "products": [ "species_742343", "species_10336932" ], "modifiers": [ [ "species_10336936", "catalyst" ] ], "additional_components": [ "ENSXETG00000039537", "ENSXETG00000039537", "ENSXETG00000017664" ] }, "reaction_10313674": { "compartment": "compartment_70101", "id": "reaction_10313674", "reactome": "R-XTR-176646", "name": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5695950", "species_158471" ], "products": [ "species_176600", "species_158466" ], "modifiers": [ [ "species_10313671", "catalyst" ] ], "additional_components": [ "F6QKH7", "ENSXETT00000042862", "L7N312", "ENSXETT00000017267" ] }, "reaction_10313639": { "compartment": "compartment_70101", "id": "reaction_10313639", "reactome": "R-XTR-176474", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176486" ], "products": [ "species_176519", "species_158466" ], "modifiers": [ [ "species_10313636", "catalyst" ] ], "additional_components": [ "F6QKH7", "ENSXETT00000042862", "L7N312", "ENSXETT00000017267", "B0BM84", "ENSXETT00000064929", "A0A6I8PTM1", "ENSXETG00000033931" ] }, "reaction_10313039": { "compartment": "compartment_5460", "id": "reaction_10313039", "reactome": "R-XTR-159566", "name": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_159447" ], "products": [ "species_29374", "species_159564" ], "modifiers": [ [ "species_10313036", "catalyst" ] ], "additional_components": [ "A0A6I8RQD3", "ENSXETG00000038499" ] }, "reaction_10313024": { "compartment": "compartment_5460", "id": "reaction_10313024", "reactome": "R-XTR-159443", "name": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_159446" ], "products": [ "species_159448", "species_159450", "species_159447" ], "modifiers": [ [ "species_10313019", "catalyst" ] ], "additional_components": [ "ENSXETT00000036505" ] }, "reaction_10313808": { "compartment": "compartment_5460", "id": "reaction_10313808", "reactome": "R-XTR-177157", "name": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_177153" ], "products": [ "species_159448", "species_159450", "species_177137" ], "modifiers": [ [ "species_10313019", "catalyst" ] ], "additional_components": [ "ENSXETT00000036505" ] }, "reaction_10313045": { "compartment": "compartment_5460", "id": "reaction_10313045", "reactome": "R-XTR-159567", "name": "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_159559" ], "products": [ "species_159448", "species_159450", "species_159557" ], "modifiers": [ [ "species_10313019", "catalyst" ] ], "additional_components": [ "ENSXETT00000036505" ] }, "reaction_10313047": { "compartment": "compartment_5460", "id": "reaction_10313047", "reactome": "R-XTR-159574", "name": "salicylate-CoA + glycine => salicyluric acid + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_159557" ], "products": [ "species_29374", "species_159572" ], "modifiers": [ [ "species_10313036", "catalyst" ] ], "additional_components": [ "A0A6I8RQD3", "ENSXETG00000038499" ] }, "reaction_10332302": { "compartment": "compartment_70101", "id": "reaction_10332302", "reactome": "R-XTR-6786190", "name": "CMBL hydrolyses OM to OLMS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6786175" ], "products": [ "species_6786194", "species_6786179" ], "modifiers": [ [ "species_10332299", "catalyst" ] ], "additional_components": [ "ENSXETT00000054521" ] }, "reaction_10331432": { "compartment": "compartment_5460", "id": "reaction_10331432", "reactome": "R-XTR-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10311857", "catalyst" ] ], "additional_components": [ "A0A6I8RHR6", "ENSXETG00000020930" ] }, "reaction_10311851": { "compartment": "compartment_70101", "id": "reaction_10311851", "reactome": "R-XTR-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_29510", "species_73473" ], "modifiers": [ [ "species_10311848", "catalyst" ] ], "additional_components": [ "A0A6I8RYK1", "ENSXETG00000032351", "species_29426", "F7DZV1", "ENSXETT00000020485", "F6YU63", "ENSXETT00000024409", "A0A6I8PVR9", "ENSXETG00000032433" ] }, "reaction_10331211": { "compartment": "compartment_70101", "id": "reaction_10331211", "reactome": "R-XTR-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_5692249", "species_70106", "species_73473" ], "modifiers": [ [ "species_10331208", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8PVR9", "ENSXETG00000032433", "A0A6I8RYK1", "ENSXETG00000032351", "F6YU63", "ENSXETT00000024409", "F7DZV1", "ENSXETT00000020485" ] }, "reaction_10311860": { "compartment": "compartment_5460", "id": "reaction_10311860", "reactome": "R-XTR-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10311857", "catalyst" ] ], "additional_components": [ "A0A6I8RHR6", "ENSXETG00000020930" ] }, "reaction_10331448": { "compartment": "compartment_984", "id": "reaction_10331448", "reactome": "R-XTR-5696131", "name": "AOC1 deaminates Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_390899", "species_352327" ], "products": [ "species_351626", "species_2022135", "species_351629", "species_5696128" ], "modifiers": [ [ "species_10331445", "catalyst" ] ], "additional_components": [ "species_74112", "CHEBI:28694", "A0A6I8R549", "ENSXETG00000011988" ] }, "reaction_10316604": { "compartment": "compartment_17960", "id": "reaction_10316604", "reactome": "R-XTR-217258", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_217315" ], "products": [ "species_113519", "species_113564", "species_217320" ], "modifiers": [ [ "species_10316601", "catalyst" ] ], "additional_components": [ "species_109496", "species_113596", "A0A6I8RVH1", "ENSXETG00000009900", "A0A6I8R1H4", "ENSXETG00000025145" ] }, "reaction_10312825": { "compartment": "compartment_17957", "id": "reaction_10312825", "reactome": "R-XTR-139970", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30373", "species_113601" ], "products": [ "species_113519", "species_113564", "species_140963" ], "modifiers": [ [ "species_10312822", "catalyst" ] ], "additional_components": [ "species_113596", "A0A6I8Q243", "ENSXETG00000025142" ] }, "reaction_10316593": { "compartment": "compartment_17960", "id": "reaction_10316593", "reactome": "R-XTR-217255", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_159154" ], "products": [ "species_113519", "species_113564", "species_217269" ], "modifiers": [ [ "species_10316590", "catalyst" ] ], "additional_components": [ "A0A6I8RVH1", "ENSXETG00000009900", "A0A6I8R1H4", "ENSXETG00000025145", "species_113596" ] }, "reaction_10312236": { "compartment": "compartment_12045", "id": "reaction_10312236", "reactome": "R-XTR-76496", "name": "PTGIS, CYP8A1 isomerise PGH2 to PGI2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30138" ], "products": [ "species_31593" ], "modifiers": [ [ "species_10312233", "catalyst" ] ], "additional_components": [ "ENSXETG00000001780" ] }, "reaction_10316443": { "compartment": "compartment_12045", "id": "reaction_10316443", "reactome": "R-XTR-212007", "name": "CYP26A1,B1 4-hydroxylate atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_215573", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215584" ], "modifiers": [ [ "species_10316440", "catalyst" ] ], "additional_components": [ "ENSXETG00000021546" ] }, "reaction_10316086": { "compartment": "compartment_70101", "id": "reaction_10316086", "reactome": "R-XTR-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_8963870", "species_29364" ], "products": [ "species_8963879", "species_29356", "species_29366" ], "modifiers": [ [ "species_10316083", "catalyst" ] ], "additional_components": [ "ENSXETT00000021283" ] }, "reaction_10312222": { "compartment": "compartment_12045", "id": "reaction_10312222", "reactome": "R-XTR-76453", "name": "Coumarin is 7-hydroxylated by CYP2A6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_76328", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76452" ], "modifiers": [ [ "species_10312219", "catalyst" ] ], "additional_components": [ "A0A6I8T1P2", "ENSXETG00000027556" ] }, "reaction_10316377": { "compartment": "compartment_12045", "id": "reaction_10316377", "reactome": "R-XTR-211948", "name": "CYP3A4 can N-demethylate loperamide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_213155" ], "products": [ "species_113519", "species_113564", "species_213151" ], "modifiers": [ [ "species_10316374", "catalyst" ] ], "additional_components": [ "F7B981", "ENSXETT00000026362", "A0A6I8Q6H5", "ENSXETT00000026362" ] }, "reaction_10316372": { "compartment": "compartment_12045", "id": "reaction_10316372", "reactome": "R-XTR-211929", "name": "CYP2C19 5-hydroxylates omeprazole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211892", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211944" ], "modifiers": [ [ "species_10316367", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10316436": { "compartment": "compartment_12045", "id": "reaction_10316436", "reactome": "R-XTR-212005", "name": "CYP2F1 dehydrogenates 3-methylindole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_213162", "species_113601" ], "products": [ "species_113519", "species_113564", "species_213163" ], "modifiers": [ [ "species_10316433", "catalyst" ] ], "additional_components": [ "A0A6I8QHP5", "ENSXETG00000035878" ] }, "reaction_10316564": { "compartment": "compartment_12045", "id": "reaction_10316564", "reactome": "R-XTR-213175", "name": "CYP3A4,5 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_156522", "species_113601" ], "products": [ "species_113519", "species_113564", "species_156523" ], "modifiers": [ [ "species_10316561", "catalyst" ] ], "additional_components": [ "A0A6I8Q6H5", "ENSXETT00000026362", "F7B981", "ENSXETT00000026362" ] }, "reaction_10316370": { "compartment": "compartment_12045", "id": "reaction_10316370", "reactome": "R-XTR-211910", "name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211906", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211894" ], "modifiers": [ [ "species_10316367", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10316365": { "compartment": "compartment_12045", "id": "reaction_10316365", "reactome": "R-XTR-211882", "name": "CYP3A7 can 6beta-hydroxylate testosterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30321", "species_113601" ], "products": [ "species_113519", "species_113564", "species_213144" ], "modifiers": [ [ "species_10316362", "catalyst" ] ], "additional_components": [ "A0A6I8Q6H5", "ENSXETT00000026362", "F7B981", "ENSXETT00000026362" ] }, "reaction_10316431": { "compartment": "compartment_12045", "id": "reaction_10316431", "reactome": "R-XTR-212004", "name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_211939" ], "products": [ "species_113519", "species_113564", "species_211927" ], "modifiers": [ [ "species_10316428", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312207": { "compartment": "compartment_17960", "id": "reaction_10312207", "reactome": "R-XTR-76373", "name": "N-hydroxylation of 4-aminobiphenyl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_47687", "species_113601" ], "products": [ "species_113519", "species_113564", "species_34889" ], "modifiers": [ [ "species_10312204", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10312215": { "compartment": "compartment_17960", "id": "reaction_10312215", "reactome": "R-XTR-76426", "name": "N-atom dealkylation of caffeine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_40727", "species_113601" ], "products": [ "species_143501", "species_113519", "species_113564", "species_76424" ], "modifiers": [ [ "species_10312204", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10316426": { "compartment": "compartment_12045", "id": "reaction_10316426", "reactome": "R-XTR-211991", "name": "Cyclophosphamide is 4-hydroxylated by CYP2B6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211977", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211967" ], "modifiers": [ [ "species_10316423", "catalyst" ] ], "additional_components": [ "A0A6I8QHP5", "ENSXETG00000035878" ] }, "reaction_10316421": { "compartment": "compartment_12045", "id": "reaction_10316421", "reactome": "R-XTR-211988", "name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211855", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211937" ], "modifiers": [ [ "species_10316367", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312227": { "compartment": "compartment_12045", "id": "reaction_10312227", "reactome": "R-XTR-76472", "name": "Ethylene is oxidized to Ethylene oxide by CYP1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_38985", "species_113601" ], "products": [ "species_113519", "species_113564", "species_38987" ], "modifiers": [ [ "species_10312224", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10312217": { "compartment": "compartment_17960", "id": "reaction_10312217", "reactome": "R-XTR-76434", "name": "Dehalogenation of carbon tetrachloride to form a free radical", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40887" ], "products": [ "species_29572", "species_76433" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312200": { "compartment": "compartment_17960", "id": "reaction_10312200", "reactome": "R-XTR-76354", "name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_39417", "species_113601" ], "products": [ "species_156524", "species_113519", "species_113564" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312213": { "compartment": "compartment_17960", "id": "reaction_10312213", "reactome": "R-XTR-76416", "name": "Benzene is hydroxylated to phenol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_31711", "species_156540", "species_113601" ], "products": [ "species_113519", "species_29630", "species_113564" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312229": { "compartment": "compartment_17960", "id": "reaction_10312229", "reactome": "R-XTR-76475", "name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_40795", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76474", "species_76473" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312881": { "compartment": "compartment_17957", "id": "reaction_10312881", "reactome": "R-XTR-143468", "name": "MEOS oxidizes ethanol to acetaldehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113748", "species_113601" ], "products": [ "species_113519", "species_113564", "species_113745" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10312211": { "compartment": "compartment_17957", "id": "reaction_10312211", "reactome": "R-XTR-76397", "name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_113564", "species_39427", "species_113555" ], "products": [ "species_113519", "species_76396", "species_113601" ], "modifiers": [ [ "species_10312197", "catalyst" ] ], "additional_components": [ "A0A6I8PUP3", "ENSXETG00000033706" ] }, "reaction_10316354": { "compartment": "compartment_12045", "id": "reaction_10316354", "reactome": "R-XTR-211881", "name": "Coumarin is 7-hydroxylated by CYP2A13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_76328", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76452" ], "modifiers": [ [ "species_10316351", "catalyst" ] ], "additional_components": [ "F6SM60", "ENSXETT00000031981", "A0A6I8RC71", "ENSXETG00000024858", "A0A6I8Q180", "ENSXETG00000027561", "A0A6I8T1P2", "ENSXETG00000027556", "F6XRS5", "ENSXETT00000042326" ] }, "reaction_10316349": { "compartment": "compartment_17960", "id": "reaction_10316349", "reactome": "R-XTR-211874", "name": "CYP2S1 4-hydroxylates atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_215573", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215584" ], "modifiers": [ [ "species_10312173", "catalyst" ] ], "additional_components": [ "ENSXETG00000035878" ] }, "reaction_10316394": { "compartment": "compartment_17960", "id": "reaction_10316394", "reactome": "R-XTR-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_216620", "species_113519", "species_113564" ], "modifiers": [ [ "species_10316391", "catalyst" ] ], "additional_components": [ "ENSXETT00000042586" ] }, "reaction_10316419": { "compartment": "compartment_17960", "id": "reaction_10316419", "reactome": "R-XTR-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_216547" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10316416", "catalyst" ] ], "additional_components": [ "A0A6I8PZZ5", "ENSXETG00000034285", "F7AA19", "ENSXETT00000010485", "A0A6I8S3Z7", "ENSXETG00000034657", "A0A6I8QTX8", "ENSXETT00000010485", "A0A6I8Q285", "ENSXETG00000031264" ] }, "reaction_10316387": { "compartment": "compartment_17960", "id": "reaction_10316387", "reactome": "R-XTR-211959", "name": "CYP3A43 6b-hydroxylates TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30321", "species_113601" ], "products": [ "species_113519", "species_113564", "species_213144" ], "modifiers": [ [ "species_10316360", "catalyst" ] ], "additional_components": [ "A0A6I8Q6H5", "ENSXETT00000026362", "F7B981", "ENSXETT00000026362" ] }, "reaction_10314222": { "compartment": "compartment_70101", "id": "reaction_10314222", "reactome": "R-XTR-192061", "name": "CYP46A1 24-hydroxylates CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193384", "species_29368", "species_29364" ], "products": [ "species_192060", "species_29356", "species_29366" ], "modifiers": [ [ "species_10314219", "catalyst" ] ], "additional_components": [ "ENSXETG00000032861" ] }, "reaction_10314297": { "compartment": "compartment_5460", "id": "reaction_10314297", "reactome": "R-XTR-193997", "name": "CYP11B1 oxidises 11DCORT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_193998", "species_113529", "species_113600" ], "products": [ "species_113563", "species_194011", "species_113521" ], "modifiers": [ [ "species_10314289", "catalyst" ] ], "additional_components": [ "ENSXETG00000037871" ] }, "reaction_10314299": { "compartment": "compartment_5460", "id": "reaction_10314299", "reactome": "R-XTR-194017", "name": "CYP11B2 oxidises 11DCORST to CORST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_193988", "species_113600" ], "products": [ "species_113563", "species_194005", "species_113521" ], "modifiers": [ [ "species_10314289", "catalyst" ] ], "additional_components": [ "ENSXETG00000037871" ] }, "reaction_10314292": { "compartment": "compartment_5460", "id": "reaction_10314292", "reactome": "R-XTR-193965", "name": "CYP11B2 oxidises 18HCORST to ALDO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194012", "species_113533", "species_113529", "species_113600" ], "products": [ "species_193982", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314289", "catalyst" ] ], "additional_components": [ "ENSXETG00000037871" ] }, "reaction_10314294": { "compartment": "compartment_5460", "id": "reaction_10314294", "reactome": "R-XTR-193995", "name": "CYP11B2 18-hydroxylates CORST to 18HCORST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_194005", "species_113600" ], "products": [ "species_194012", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314289", "catalyst" ] ], "additional_components": [ "ENSXETG00000037871" ] }, "reaction_10316384": { "compartment": "compartment_70101", "id": "reaction_10316384", "reactome": "R-XTR-211951", "name": "CYP1B1 4-hydroxylates EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193132", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_211973" ], "modifiers": [ [ "species_10316381", "catalyst" ] ], "additional_components": [ "ENSXETG00000038590" ] }, "reaction_10314224": { "compartment": "compartment_5460", "id": "reaction_10314224", "reactome": "R-XTR-192123", "name": "CYP27A1 27-hydroxylates CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_193840", "species_113600" ], "products": [ "species_113563", "species_193846", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10331223": { "compartment": "compartment_70101", "id": "reaction_10331223", "reactome": "R-XTR-5692283", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692409", "species_29356", "species_29366" ], "products": [ "species_70106", "species_5692433", "species_29364" ], "modifiers": [ [ "species_10331220", "catalyst" ] ], "additional_components": [ "ENSXETT00000029530" ] }, "reaction_10331315": { "compartment": "compartment_17957", "id": "reaction_10331315", "reactome": "R-XTR-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_156540", "species_5693711", "species_5693712" ], "modifiers": [ [ "species_10331312", "catalyst" ] ], "additional_components": [ "A0A6I8Q0V4", "ENSXETG00000030902", "A0A5G3JDL4", "ENSXETT00000103127" ] }, "reaction_10336179": { "compartment": "compartment_70101", "id": "reaction_10336179", "reactome": "R-XTR-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10336176", "catalyst" ] ], "additional_components": [ "A0A5G3JDL4", "ENSXETT00000103127", "A0A6I8Q0V4", "ENSXETG00000030902" ] }, "reaction_10336114": { "compartment": "compartment_70101", "id": "reaction_10336114", "reactome": "R-XTR-8936442", "name": "MARC1,MARC2 reduce N-hydroxylated compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_8936443", "species_73473" ], "products": [ "species_29356", "species_29468", "species_29360" ], "modifiers": [ [ "species_10336111", "catalyst" ] ], "additional_components": [ "A0A1B8Y4Y6", "ENSXETT00000087008", "CHEBI:21437", "F6WBG7", "ENSXETT00000038708" ] }, "reaction_10329678": { "compartment": "compartment_70101", "id": "reaction_10329678", "reactome": "R-XTR-5423672", "name": "CYP1A2, 3A4 oxidise AFB1 to AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_5423605", "species_29364" ], "products": [ "species_5423663", "species_29356", "species_29366" ], "modifiers": [ [ "species_10329675", "catalyst" ] ], "additional_components": [ "A4IGV4", "ENSXETT00000061279", "F7B981", "ENSXETT00000026362", "A0A6I8Q6H5", "ENSXETT00000026362" ] }, "reaction_10329673": { "compartment": "compartment_70101", "id": "reaction_10329673", "reactome": "R-XTR-5423664", "name": "CYP3A4,5 hydroxylates AFB1 to AFQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_5423605", "species_29364" ], "products": [ "species_5423660", "species_29356", "species_29366" ], "modifiers": [ [ "species_10329670", "catalyst" ] ], "additional_components": [ "F7B981", "ENSXETT00000026362", "A0A6I8Q6H5", "ENSXETT00000026362" ] }, "reaction_10329707": { "compartment": "compartment_70101", "id": "reaction_10329707", "reactome": "R-XTR-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_2022890", "species_5490231" ], "modifiers": [ [ "species_10329704", "catalyst" ] ], "additional_components": [ "CHEBI:78580", "CHEBI:78585", "CHEBI:78583", "CHEBI:78578", "species_29426", "A0A6I8PUM5", "ENSXETG00000032120" ] }, "reaction_10329668": { "compartment": "compartment_70101", "id": "reaction_10329668", "reactome": "R-XTR-5423653", "name": "MGST trimers transfer GS from GSH to AFXBO and AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5423723" ], "products": [ "species_5423730" ], "modifiers": [ [ "species_10313607", "catalyst" ] ], "additional_components": [ "species_156523", "species_5423663", "CHEBI:78581", "CHEBI:78587", "A0A6I8RJ83", "ENSXETG00000036671", "F6PX96", "ENSXETT00000016673", "F6VC96", "ENSXETT00000010309" ] }, "reaction_10312902": { "compartment": "compartment_70101", "id": "reaction_10312902", "reactome": "R-XTR-156526", "name": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_5423605", "species_29364" ], "products": [ "species_29356", "species_159211", "species_29366" ], "modifiers": [ [ "species_10312899", "catalyst" ] ], "additional_components": [ "A4IGV4", "ENSXETT00000061279", "F7B981", "ENSXETT00000026362", "A0A6I8Q6H5", "ENSXETT00000026362", "F6SM60", "ENSXETT00000031981", "A0A6I8RC71", "ENSXETG00000024858", "A0A6I8Q180", "ENSXETG00000027561", "A0A6I8T1P2", "ENSXETG00000027556", "F6XRS5", "ENSXETT00000042326" ] }, "reaction_10337910": { "compartment": "compartment_70101", "id": "reaction_10337910", "reactome": "R-XTR-9638046", "name": "ACY3:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_2022890", "species_5490231" ], "modifiers": [ [ "species_10337907", "catalyst" ] ], "additional_components": [ "CHEBI:78580", "CHEBI:78585", "CHEBI:78583", "CHEBI:78578", "species_29426", "Q5BJ91", "ENSXETT00000019664" ] }, "reaction_10329680": { "compartment": "compartment_12045", "id": "reaction_10329680", "reactome": "R-XTR-5423678", "name": "CYP1A2 hydroxylates AFB1 to AFM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_5423605", "species_29364" ], "products": [ "species_5423629", "species_29356", "species_29366" ], "modifiers": [ [ "species_10312204", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10329666": { "compartment": "compartment_70101", "id": "reaction_10329666", "reactome": "R-XTR-5423647", "name": "CYP2A13 oxidises AFM1 to AFM1E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5423629", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_5423657", "species_29366" ], "modifiers": [ [ "species_10312195", "catalyst" ] ], "additional_components": [ "F6SM60", "ENSXETT00000031981", "A0A6I8RC71", "ENSXETG00000024858", "A0A6I8Q180", "ENSXETG00000027561", "A0A6I8T1P2", "ENSXETG00000027556", "F6XRS5", "ENSXETT00000042326" ] }, "reaction_10315625": { "compartment": "compartment_876", "id": "reaction_10315625", "reactome": "R-XTR-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10315622", "catalyst" ] ], "additional_components": [ "A0A6I8PTQ0", "ENSXETG00000014772", "F6TI71", "ENSXETT00000005158" ] }, "reaction_10314029": { "compartment": "compartment_7660", "id": "reaction_10314029", "reactome": "R-XTR-187937", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314001", "species_10314025" ], "products": [ "species_10314027" ], "modifiers": [], "additional_components": [ "F6T0J1", "ENSXETT00000046130", "ENSXETG00000000021", "A0A6I8QJI3", "ENSXETG00000000021", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10314040": { "compartment": "compartment_7660", "id": "reaction_10314040", "reactome": "R-XTR-187959", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10314027" ], "products": [ "species_113582", "species_10314037" ], "modifiers": [ [ "species_10314027", "catalyst" ] ], "additional_components": [ "A0A6I8QJI3", "ENSXETG00000000021", "F6T0J1", "ENSXETT00000046130", "F6T0J1", "ENSXETT00000046130", "A0A6I8QJI3", "ENSXETG00000000021", "A0A6I8QJI3", "ENSXETG00000000021", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10327234": { "compartment": "compartment_70101", "id": "reaction_10327234", "reactome": "R-XTR-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327232" ], "products": [ "species_10313135" ], "modifiers": [], "additional_components": [ "ENSXETT00000022754", "ENSXETT00000022754" ] }, "reaction_10328464": { "compartment": "compartment_7660", "id": "reaction_10328464", "reactome": "R-XTR-4088024", "name": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10328459" ], "products": [ "species_113582", "species_10328462" ], "modifiers": [ [ "species_10314001", "catalyst" ] ], "additional_components": [ "ENSXETG00000035621", "ENSXETG00000035621", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10335127": { "compartment": "compartment_70101", "id": "reaction_10335127", "reactome": "R-XTR-8852331", "name": "GTSE1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335118" ], "products": [ "species_10335125" ], "modifiers": [], "additional_components": [ "ENSXETT00000061292", "ENSXETT00000061292" ] }, "reaction_10335121": { "compartment": "compartment_70101", "id": "reaction_10335121", "reactome": "R-XTR-8852317", "name": "PLK1 phosphorylates GTSE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10335115" ], "products": [ "species_10327232", "species_29370", "species_10335118" ], "modifiers": [ [ "species_10335115", "catalyst" ] ], "additional_components": [ "Q28DF6", "ENSXETT00000061292", "P62205", "ENSXETT00000022754", "ENSXETT00000022754", "ENSXETT00000061292", "Q28DF6", "ENSXETT00000061292", "P62205", "ENSXETT00000022754" ] }, "reaction_10335123": { "compartment": "compartment_70101", "id": "reaction_10335123", "reactome": "R-XTR-8852324", "name": "GTSE1 binds PLK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327232", "species_10335113" ], "products": [ "species_10335115" ], "modifiers": [], "additional_components": [ "ENSXETT00000022754", "ENSXETT00000061292", "Q28DF6", "ENSXETT00000061292", "P62205", "ENSXETT00000022754" ] }, "reaction_10328475": { "compartment": "compartment_7660", "id": "reaction_10328475", "reactome": "R-XTR-4088134", "name": "PLK1 phosphorylates FOXM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328466", "species_29358" ], "products": [ "species_113582", "species_10328472", "species_10313135" ], "modifiers": [ [ "species_10328466", "catalyst" ] ], "additional_components": [ "P62205", "ENSXETT00000022754", "A0A6I8RBK3", "ENSXETG00000035621", "ENSXETG00000035621", "ENSXETT00000022754", "P62205", "ENSXETT00000022754", "A0A6I8RBK3", "ENSXETG00000035621" ] }, "reaction_10328468": { "compartment": "compartment_7660", "id": "reaction_10328468", "reactome": "R-XTR-4088130", "name": "PLK1 binds FOXM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328462", "species_10313135" ], "products": [ "species_10328466" ], "modifiers": [], "additional_components": [ "ENSXETG00000035621", "ENSXETT00000022754", "P62205", "ENSXETT00000022754", "A0A6I8RBK3", "ENSXETG00000035621" ] }, "reaction_10324271": { "compartment": "compartment_70101", "id": "reaction_10324271", "reactome": "R-XTR-1855216", "name": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_29370", "species_1629740" ], "modifiers": [ [ "species_10324253", "catalyst" ] ], "additional_components": [ "ENSXETT00000018584" ] }, "reaction_10324302": { "compartment": "compartment_70101", "id": "reaction_10324302", "reactome": "R-XTR-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_1629765", "species_29370" ], "modifiers": [ [ "species_10324235", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324296": { "compartment": "compartment_70101", "id": "reaction_10324296", "reactome": "R-XTR-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10324235", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324262": { "compartment": "compartment_70101", "id": "reaction_10324262", "reactome": "R-XTR-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10324235", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324240": { "compartment": "compartment_70101", "id": "reaction_10324240", "reactome": "R-XTR-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10324235", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324256": { "compartment": "compartment_70101", "id": "reaction_10324256", "reactome": "R-XTR-1855182", "name": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10324253", "catalyst" ] ], "additional_components": [ "ENSXETT00000018584" ] }, "reaction_10324259": { "compartment": "compartment_70101", "id": "reaction_10324259", "reactome": "R-XTR-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10324235", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10331934": { "compartment": "compartment_70101", "id": "reaction_10331934", "reactome": "R-XTR-5696627", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10331927" ], "products": [ "species_10331931", "species_10313391" ], "modifiers": [ [ "species_10331927", "catalyst" ] ], "additional_components": [ "A0A6I8SGS6", "ENSXETG00000031250", "A0A6I8RKP9", "ENSXETG00000031817", "Q28DL4", "ENSXETG00000007549", "A0A6I8RKP9", "ENSXETG00000031817", "Q28DL4", "ENSXETG00000007549", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8SGS6", "ENSXETG00000031250", "A0A6I8RKP9", "ENSXETG00000031817", "Q28DL4", "ENSXETG00000007549" ] }, "reaction_10320632": { "compartment": "compartment_70101", "id": "reaction_10320632", "reactome": "R-XTR-936390", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320623" ], "products": [ "species_10320625", "species_10312116" ], "modifiers": [ [ "species_10320629", "catalyst" ] ], "additional_components": [ "ENSXETG00000009200", "ENSXETG00000009200", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "ENSXETG00000031250" ] }, "reaction_10331914": { "compartment": "compartment_7660", "id": "reaction_10331914", "reactome": "R-XTR-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10331767" ], "products": [ "species_10331911", "species_10331769" ], "modifiers": [ [ "species_10331767", "catalyst" ] ], "additional_components": [ "A0A6I8RK73", "ENSXETG00000005089", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8RK73", "ENSXETG00000005089", "A0A6I8RK73", "ENSXETG00000005089" ] }, "reaction_10332196": { "compartment": "compartment_17906", "id": "reaction_10332196", "reactome": "R-XTR-5696872", "name": "USP30 deubiquitinates Ub-MOM proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10331979" ], "products": [ "species_10332193", "species_10331995" ], "modifiers": [ [ "species_10331979", "catalyst" ] ], "additional_components": [ "Q6DFM9", "ENSXETT00000098526", "A4QNN3", "ENSXETT00000048254", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q6DFM9", "ENSXETT00000098526", "A4QNN3", "ENSXETT00000048254", "Q6DFM9", "ENSXETT00000098526", "A4QNN3", "ENSXETT00000048254" ] }, "reaction_10330999": { "compartment": "compartment_7660", "id": "reaction_10330999", "reactome": "R-XTR-5690157", "name": "USP16,USP21 deubiquitinate Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10330994" ], "products": [ "species_10327687", "species_10330996" ], "modifiers": [ [ "species_10330994", "catalyst" ] ], "additional_components": [ "Q0VA64", "ENSXETG00000020255", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q0VA64", "ENSXETG00000020255", "Q0VA64", "ENSXETG00000020255" ] }, "reaction_10332214": { "compartment": "compartment_7660", "id": "reaction_10332214", "reactome": "R-XTR-5696997", "name": "USP24 deubiquitinates DDB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10332207" ], "products": [ "species_10332211", "species_10331911" ], "modifiers": [ [ "species_10332207", "catalyst" ] ], "additional_components": [ "Q66JG1", "ENSXETT00000008619", "A0A6I8SCT2", "ENSXETG00000009543", "A0A6I8SCT2", "ENSXETG00000009543", "Q66JG1", "ENSXETT00000008619", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q66JG1", "ENSXETT00000008619", "A0A6I8SCT2", "ENSXETG00000009543" ] }, "reaction_10331760": { "compartment": "compartment_70101", "id": "reaction_10331760", "reactome": "R-XTR-5696600", "name": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10331549" ], "products": [ "species_10331555", "species_10331757" ], "modifiers": [ [ "species_10331549", "catalyst" ] ], "additional_components": [ "F7BNK9", "ENSXETT00000015033", "A0A6I8SFY9", "ENSXETG00000009200", "B7ZT68", "ENSXETT00000056088", "F7BNK9", "ENSXETT00000015033", "B7ZT68", "ENSXETT00000056088", "A0A6I8SFY9", "ENSXETG00000009200", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7BNK9", "ENSXETT00000015033", "A0A6I8SFY9", "ENSXETG00000009200", "B7ZT68", "ENSXETT00000056088" ] }, "reaction_10331173": { "compartment": "compartment_70101", "id": "reaction_10331173", "reactome": "R-XTR-5691439", "name": "BRISC complex deubiquitinates NLRP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10331164" ], "products": [ "species_10331168", "species_10313391" ], "modifiers": [ [ "species_10331164", "catalyst" ] ], "additional_components": [ "Q5M8J0", "ENSXETG00000025571", "Q4VA72", "ENSXETG00000026184", "Q6P4W0", "ENSXETG00000023627", "Q6DJ78", "ENSXETG00000010201", "Q5M8J0", "ENSXETG00000025571", "Q4VA72", "ENSXETG00000026184", "Q6P4W0", "ENSXETG00000023627", "Q6DJ78", "ENSXETG00000010201", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q5M8J0", "ENSXETG00000025571", "Q4VA72", "ENSXETG00000026184", "Q6P4W0", "ENSXETG00000023627", "Q6DJ78", "ENSXETG00000010201" ] }, "reaction_10331071": { "compartment": "compartment_7660", "id": "reaction_10331071", "reactome": "R-XTR-5690759", "name": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10331006" ], "products": [ "species_10331010", "species_10331068" ], "modifiers": [ [ "species_10331006", "catalyst" ] ], "additional_components": [ "A0A6I8QTP5", "ENSXETG00000014251", "Q66JB6", "ENSXETG00000000091", "Q66JB6", "ENSXETG00000000091", "A0A6I8QTP5", "ENSXETG00000014251", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8QTP5", "ENSXETG00000014251", "Q66JB6", "ENSXETG00000000091" ] }, "reaction_10331073": { "compartment": "compartment_7660", "id": "reaction_10331073", "reactome": "R-XTR-5690785", "name": "BAP1 binds Ub-HCFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330919", "species_10331004" ], "products": [ "species_10331006" ], "modifiers": [], "additional_components": [ "ENSXETG00000000091", "ENSXETG00000014251", "A0A6I8QTP5", "ENSXETG00000014251", "Q66JB6", "ENSXETG00000000091" ] }, "reaction_10335867": { "compartment": "compartment_70101", "id": "reaction_10335867", "reactome": "R-XTR-8869506", "name": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10335864" ], "products": [ "species_10331090", "species_10313391" ], "modifiers": [ [ "species_10335864", "catalyst" ] ], "additional_components": [ "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765", "Q28DL4", "ENSXETG00000007549", "Q28DL4", "ENSXETG00000007549", "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765", "Q28DL4", "ENSXETG00000007549" ] }, "reaction_10331093": { "compartment": "compartment_70101", "id": "reaction_10331093", "reactome": "R-XTR-5690870", "name": "OTUD7B,TNFAIP3 deubiquitinate TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331088", "species_29356" ], "products": [ "species_10331090", "species_10330519" ], "modifiers": [ [ "species_10331088", "catalyst" ] ], "additional_components": [ "Q28DL4", "ENSXETG00000007549", "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765", "Q28DL4", "ENSXETG00000007549", "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q28DL4", "ENSXETG00000007549", "B1H2Q2", "ENSXETG00000023629", "A0A6I8QSL0", "ENSXETG00000015765" ] }, "reaction_10330909": { "compartment": "compartment_70101", "id": "reaction_10330909", "reactome": "R-XTR-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10313391" ], "products": [ "species_10313391", "species_10313389" ], "modifiers": [ [ "species_10330906", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "ENSXETT00000006019" ] }, "reaction_10325869": { "compartment": "compartment_70101", "id": "reaction_10325869", "reactome": "R-XTR-2038398", "name": "KIBRA (WWC1) binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325797", "species_10325865" ], "products": [ "species_10325867" ], "modifiers": [], "additional_components": [ "ENSXETT00000026288", "ENSXETG00000016462", "A4IIJ3", "ENSXETG00000016462", "F6U2R0", "ENSXETT00000026288" ] }, "reaction_10325851": { "compartment": "compartment_70101", "id": "reaction_10325851", "reactome": "R-XTR-2032770", "name": "Translocation of YAP1 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325815" ], "products": [ "species_10325849" ], "modifiers": [], "additional_components": [ "ENSXETG00000032689", "ENSXETG00000032689" ] }, "reaction_10325835": { "compartment": "compartment_70101", "id": "reaction_10325835", "reactome": "R-XTR-2028644", "name": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312802", "species_10325818" ], "products": [ "species_10325833" ], "modifiers": [], "additional_components": [ "Q5XGC8", "ENSXETG00000022830", "ENSXETG00000032689", "A0A6I8SYU4", "ENSXETG00000032689", "Q5XGC8", "ENSXETG00000022830" ] }, "reaction_10325829": { "compartment": "compartment_70101", "id": "reaction_10325829", "reactome": "R-XTR-2028626", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325797", "species_10325803" ], "products": [ "species_10325805" ], "modifiers": [], "additional_components": [ "ENSXETT00000026288", "ENSXETT00000073958", "Q28FB5", "ENSXETT00000073958", "F6U2R0", "ENSXETT00000026288" ] }, "reaction_10325942": { "compartment": "compartment_70101", "id": "reaction_10325942", "reactome": "R-XTR-2059926", "name": "NPHP4 protein binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325938", "species_10325797" ], "products": [ "species_10325940" ], "modifiers": [], "additional_components": [ "ENSXETG00000002886", "ENSXETT00000026288", "F6U2R0", "ENSXETT00000026288", "A0A6I8SDY8", "ENSXETG00000002886" ] }, "reaction_10325843": { "compartment": "compartment_70101", "id": "reaction_10325843", "reactome": "R-XTR-2028724", "name": "AMOT proteins bind YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325815", "species_10325839" ], "products": [ "species_10325841" ], "modifiers": [], "additional_components": [ "ENSXETG00000032689", "ENSXETG00000006385", "A0A6I8SVS3", "ENSXETG00000006385", "A0A6I8SYU4", "ENSXETG00000032689" ] }, "reaction_10325827": { "compartment": "compartment_70101", "id": "reaction_10325827", "reactome": "R-XTR-2028598", "name": "Phosphorylation of YAP by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325815", "species_113592" ], "products": [ "species_10325824", "species_29370" ], "modifiers": [ [ "species_10325811", "catalyst" ] ], "additional_components": [ "ENSXETG00000032689", "ENSXETG00000032689", "Q28FB5", "ENSXETT00000073958", "F6U2R0", "ENSXETT00000026288" ] }, "reaction_10335596": { "compartment": "compartment_876", "id": "reaction_10335596", "reactome": "R-XTR-8858498", "name": "SL (surrogate light chain) binds IgH to form pre-BCR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335536", "species_10335592" ], "products": [ "species_10335594" ], "modifiers": [], "additional_components": [ "A0A6I8QLS0", "ENSXETG00000041230", "A0A6I8QM25", "ENSXETG00000041230", "A0A6I8PTS9", "ENSXETG00000041230", "A0A6I8RSN1", "ENSXETG00000041230", "A0A6I8PUH7", "ENSXETG00000041230", "A0A6I8S9Z8", "ENSXETG00000041230", "A0A6I8PM56", "ENSXETG00000041230", "A0A6I8RJH0", "ENSXETG00000041230", "A0A6I8PMK7", "ENSXETG00000041230", "A0A6I8RS78", "ENSXETG00000041230", "A0A6I8R4R2", "ENSXETG00000041230", "A0A6I8R767", "ENSXETG00000041230", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8RSK9", "ENSXETG00000040383", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8QKP4", "ENSXETG00000040212", "A0A6I8SYV6", "ENSXETG00000040212", "A0A6I8RUJ4", "ENSXETG00000040212", "A0A6I8SK71", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8RNX1", "ENSXETG00000040212", "A0A6I8QZL1", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212", "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8R2R2", "ENSXETG00000039428", "A0A6I8RZZ7", "ENSXETG00000039428", "A0A6I8QD99", "ENSXETG00000039428", "A0A6I8QNA7", "ENSXETG00000039428", "A0A6I8Q2V3", "ENSXETG00000039428", "A0A6I8Q7C1", "ENSXETG00000039428", "A0A6I8SEP6", "ENSXETG00000039428", "A0A6I8PSU3", "ENSXETG00000039428", "F6S2S6", "ENSXETT00000022997", "A0A6I8QGS1", "ENSXETG00000040831", "A0A6I8SZD5", "ENSXETG00000034688", "A0A6I8QDF6", "ENSXETG00000037057", "A0A6I8S531", "ENSXETG00000040831", "A0A6I8Q881", "ENSXETG00000040831", "A0A6I8RG89", "ENSXETG00000040831", "A0A6I8R6G0", "ENSXETG00000040853", "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8R2R2", "ENSXETG00000039428", "A0A6I8RZZ7", "ENSXETG00000039428", "A0A6I8QD99", "ENSXETG00000039428", "A0A6I8QNA7", "ENSXETG00000039428", "A0A6I8Q2V3", "ENSXETG00000039428", "A0A6I8Q7C1", "ENSXETG00000039428", "A0A6I8SEP6", "ENSXETG00000039428", "A0A6I8PSU3", "ENSXETG00000039428", "F6S2S6", "ENSXETT00000022997", "A0A6I8QGS1", "ENSXETG00000040831", "A0A6I8SZD5", "ENSXETG00000034688", "A0A6I8QDF6", "ENSXETG00000037057", "A0A6I8S531", "ENSXETG00000040831", "A0A6I8Q881", "ENSXETG00000040831", "A0A6I8RG89", "ENSXETG00000040831", "A0A6I8R6G0", "ENSXETG00000040853", "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8QLS0", "ENSXETG00000041230", "A0A6I8QM25", "ENSXETG00000041230", "A0A6I8PTS9", "ENSXETG00000041230", "A0A6I8RSN1", "ENSXETG00000041230", "A0A6I8PUH7", "ENSXETG00000041230", "A0A6I8S9Z8", "ENSXETG00000041230", "A0A6I8PM56", "ENSXETG00000041230", "A0A6I8RJH0", "ENSXETG00000041230", "A0A6I8PMK7", "ENSXETG00000041230", "A0A6I8RS78", "ENSXETG00000041230", "A0A6I8R4R2", "ENSXETG00000041230", "A0A6I8R767", "ENSXETG00000041230", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8RSK9", "ENSXETG00000040383", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8QKP4", "ENSXETG00000040212", "A0A6I8SYV6", "ENSXETG00000040212", "A0A6I8RUJ4", "ENSXETG00000040212", "A0A6I8SK71", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8RNX1", "ENSXETG00000040212", "A0A6I8QZL1", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212" ] }, "reaction_10315803": { "compartment": "compartment_876", "id": "reaction_10315803", "reactome": "R-XTR-202717", "name": "Heterodimerization of CEACAMs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315799" ], "products": [ "species_10315801" ], "modifiers": [], "additional_components": [ "A0A6I8QZM7", "ENSXETG00000032631", "A0A6I8R329", "ENSXETG00000038658", "A0A6I8PPZ5", "ENSXETG00000038658", "A0A6I8SB02", "ENSXETG00000038658", "A0A6I8QZM7", "ENSXETG00000032631", "A0A6I8R329", "ENSXETG00000038658", "A0A6I8PPZ5", "ENSXETG00000038658", "A0A6I8SB02", "ENSXETG00000038658" ] }, "reaction_10327047": { "compartment": "compartment_876", "id": "reaction_10327047", "reactome": "R-XTR-2870221", "name": "E-selectin binds E-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315815", "species_10315821" ], "products": [ "species_10327045" ], "modifiers": [], "additional_components": [ "ENSXETG00000038109", "ENSXETG00000039556", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8R2I7", "ENSXETG00000038109" ] }, "reaction_10315831": { "compartment": "compartment_876", "id": "reaction_10315831", "reactome": "R-XTR-202731", "name": "JAM3 dimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315807" ], "products": [ "species_10315829" ], "modifiers": [], "additional_components": [ "ENSXETG00000040710", "A0A6I8SUC1", "ENSXETG00000040710" ] }, "reaction_10335414": { "compartment": "compartment_876", "id": "reaction_10335414", "reactome": "R-XTR-8858428", "name": "FCAMR binds IgA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335410", "species_10326437" ], "products": [ "species_10335412" ], "modifiers": [], "additional_components": [ "ENSXETG00000037809", "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8QLS0", "ENSXETG00000041230", "A0A6I8QM25", "ENSXETG00000041230", "A0A6I8PTS9", "ENSXETG00000041230", "A0A6I8RSN1", "ENSXETG00000041230", "A0A6I8PUH7", "ENSXETG00000041230", "A0A6I8S9Z8", "ENSXETG00000041230", "A0A6I8PM56", "ENSXETG00000041230", "A0A6I8RJH0", "ENSXETG00000041230", "A0A6I8PMK7", "ENSXETG00000041230", "A0A6I8RS78", "ENSXETG00000041230", "A0A6I8R4R2", "ENSXETG00000041230", "A0A6I8R767", "ENSXETG00000041230", "A0A6I8RSK9", "ENSXETG00000040383", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212", "A0A6I8SK71", "ENSXETG00000040212", "A0A6I8QZL1", "ENSXETG00000040212", "A0A6I8RUJ4", "ENSXETG00000040212", "A0A6I8QKP4", "ENSXETG00000040212", "A0A6I8RNX1", "ENSXETG00000040212", "A0A6I8SYV6", "ENSXETG00000040212", "A0A6I8PWK1", "ENSXETT00000069302", "A0A6I8PXL5", "ENSXETT00000069302", "A0A5G3K4A2", "ENSXETT00000069302", "F7ATU6", "ENSXETT00000069302", "A0A6I8PNW8", "ENSXETT00000069302", "L7N2W1", "ENSXETT00000013311", "A0A6I8SSF0", "ENSXETT00000069302", "A0A6I8SYX6", "ENSXETT00000069302", "A0A6I8SF25", "ENSXETT00000069302", "A0A6I8SJ82", "ENSXETT00000069302", "A0A6I8SCS2", "ENSXETT00000069302", "A0A6I8SCZ9", "ENSXETT00000069302", "A0A6I8S4K2", "ENSXETT00000069302", "A0A6I8S824", "ENSXETT00000069302", "A0A6I8S1H6", "ENSXETT00000069302", "A0A6I8S3H5", "ENSXETT00000069302", "A0A6I8RTG9", "ENSXETT00000069302", "A0A6I8RYE0", "ENSXETT00000069302", "A0A6I8RLS5", "ENSXETT00000069302", "A0A6I8RQ73", "ENSXETT00000069302", "A0A6I8RDF6", "ENSXETT00000069302", "A0A6I8RF32", "ENSXETT00000069302", "A0A6I8R2N8", "ENSXETT00000069302", "A0A6I8R7C6", "ENSXETT00000069302", "A0A6I8QNF8", "ENSXETT00000069302", "A0A6I8QSF1", "ENSXETT00000069302", "A0A6I8QE50", "ENSXETT00000069302", "A0A6I8QMZ7", "ENSXETT00000069302", "A0A6I8Q652", "ENSXETT00000069302", "A0A6I8Q664", "ENSXETT00000069302", "A0A6I8Q2X0", "ENSXETT00000069302", "A0A6I8Q318", "ENSXETT00000069302", "A0A6I8Q0S1", "ENSXETT00000069302", "A0A6I8Q2I9", "ENSXETT00000069302", "K9J7P7", "ENSXETT00000007797", "A0A6I8PSU3", "ENSXETG00000039428", "F6S2S6", "ENSXETT00000022997", "A0A6I8Q2V3", "ENSXETG00000039428", "A0A6I8RZZ7", "ENSXETG00000039428", "A0A6I8SEP6", "ENSXETG00000039428", "A0A6I8QNA7", "ENSXETG00000039428", "A0A6I8R2R2", "ENSXETG00000039428", "A0A6I8Q7C1", "ENSXETG00000039428", "A0A6I8QD99", "ENSXETG00000039428", "A0A6I8R5U7", "ENSXETG00000034776", "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8QLS0", "ENSXETG00000041230", "A0A6I8QM25", "ENSXETG00000041230", "A0A6I8PTS9", "ENSXETG00000041230", "A0A6I8RSN1", "ENSXETG00000041230", "A0A6I8PUH7", "ENSXETG00000041230", "A0A6I8S9Z8", "ENSXETG00000041230", "A0A6I8PM56", "ENSXETG00000041230", "A0A6I8RJH0", "ENSXETG00000041230", "A0A6I8PMK7", "ENSXETG00000041230", "A0A6I8RS78", "ENSXETG00000041230", "A0A6I8R4R2", "ENSXETG00000041230", "A0A6I8R767", "ENSXETG00000041230", "A0A6I8RSK9", "ENSXETG00000040383", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212", "A0A6I8SK71", "ENSXETG00000040212", "A0A6I8QZL1", "ENSXETG00000040212", "A0A6I8RUJ4", "ENSXETG00000040212", "A0A6I8QKP4", "ENSXETG00000040212", "A0A6I8RNX1", "ENSXETG00000040212", "A0A6I8SYV6", "ENSXETG00000040212", "A0A6I8PWK1", "ENSXETT00000069302", "A0A6I8PXL5", "ENSXETT00000069302", "A0A5G3K4A2", "ENSXETT00000069302", "F7ATU6", "ENSXETT00000069302", "A0A6I8PNW8", "ENSXETT00000069302", "L7N2W1", "ENSXETT00000013311", "A0A6I8SSF0", "ENSXETT00000069302", "A0A6I8SYX6", "ENSXETT00000069302", "A0A6I8SF25", "ENSXETT00000069302", "A0A6I8SJ82", "ENSXETT00000069302", "A0A6I8SCS2", "ENSXETT00000069302", "A0A6I8SCZ9", "ENSXETT00000069302", "A0A6I8S4K2", "ENSXETT00000069302", "A0A6I8S824", "ENSXETT00000069302", "A0A6I8S1H6", "ENSXETT00000069302", "A0A6I8S3H5", "ENSXETT00000069302", "A0A6I8RTG9", "ENSXETT00000069302", "A0A6I8RYE0", "ENSXETT00000069302", "A0A6I8RLS5", "ENSXETT00000069302", "A0A6I8RQ73", "ENSXETT00000069302", "A0A6I8RDF6", "ENSXETT00000069302", "A0A6I8RF32", "ENSXETT00000069302", "A0A6I8R2N8", "ENSXETT00000069302", "A0A6I8R7C6", "ENSXETT00000069302", "A0A6I8QNF8", "ENSXETT00000069302", "A0A6I8QSF1", "ENSXETT00000069302", "A0A6I8QE50", "ENSXETT00000069302", "A0A6I8QMZ7", "ENSXETT00000069302", "A0A6I8Q652", "ENSXETT00000069302", "A0A6I8Q664", "ENSXETT00000069302", "A0A6I8Q2X0", "ENSXETT00000069302", "A0A6I8Q318", "ENSXETT00000069302", "A0A6I8Q0S1", "ENSXETT00000069302", "A0A6I8Q2I9", "ENSXETT00000069302", "K9J7P7", "ENSXETT00000007797", "A0A6I8PSU3", "ENSXETG00000039428", "F6S2S6", "ENSXETT00000022997", "A0A6I8Q2V3", "ENSXETG00000039428", "A0A6I8RZZ7", "ENSXETG00000039428", "A0A6I8SEP6", "ENSXETG00000039428", "A0A6I8QNA7", "ENSXETG00000039428", "A0A6I8R2R2", "ENSXETG00000039428", "A0A6I8Q7C1", "ENSXETG00000039428", "A0A6I8QD99", "ENSXETG00000039428", "A0A6I8R5U7", "ENSXETG00000034776", "A0A6I8QSY3", "ENSXETG00000037809" ] }, "reaction_10335808": { "compartment": "compartment_876", "id": "reaction_10335808", "reactome": "R-XTR-8867240", "name": "EPCAM binds itself to form homotypic cell adhesion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335804" ], "products": [ "species_10335806" ], "modifiers": [], "additional_components": [ "ENSXETT00000060362", "Q5U4Z2", "ENSXETT00000060362" ] }, "reaction_10315827": { "compartment": "compartment_876", "id": "reaction_10315827", "reactome": "R-XTR-202724", "name": "P-selectin binds P-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315815", "species_10315823" ], "products": [ "species_10315825" ], "modifiers": [], "additional_components": [ "ENSXETG00000038109", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8R2I7", "ENSXETG00000038109" ] }, "reaction_10327054": { "compartment": "compartment_984", "id": "reaction_10327054", "reactome": "R-XTR-2872444", "name": "SLC9B1/C2 exchange Na+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10327051", "catalyst" ] ], "additional_components": [ "ENSXETG00000021321" ] }, "reaction_10327555": { "compartment": "compartment_70101", "id": "reaction_10327555", "reactome": "R-XTR-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10327552", "catalyst" ] ], "additional_components": [ "A0A6I8QKQ2", "ENSXETG00000031787", "A0A6I8SES7", "ENSXETG00000005811", "A0A6I8SY50", "ENSXETG00000001048", "A0A6I8RF46", "ENSXETG00000008633" ] }, "reaction_10327002": { "compartment": "compartment_70101", "id": "reaction_10327002", "reactome": "R-XTR-2671885", "name": "ASIC trimers:H+ transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10326999", "catalyst" ], [ "species_2672379", "inhibitor" ], [ "species_2672383", "inhibitor" ] ], "additional_components": [ "F6W3B8", "ENSXETT00000027176", "species_156540" ] }, "reaction_10335653": { "compartment": "compartment_876", "id": "reaction_10335653", "reactome": "R-XTR-8863494", "name": "ASICs bind STOML3, (STOM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335649", "species_10326999" ], "products": [ "species_10335651" ], "modifiers": [], "additional_components": [ "ENSXETT00000104043", "F6W3B8", "ENSXETT00000027176", "species_156540", "F6W3B8", "ENSXETT00000027176", "species_156540", "A0A1B8Y5B7", "ENSXETT00000104043" ] }, "reaction_10338020": { "compartment": "compartment_876", "id": "reaction_10338020", "reactome": "R-XTR-9650165", "name": "ASIC trimers bind H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338018", "species_351626" ], "products": [ "species_10326999" ], "modifiers": [], "additional_components": [ "F6W3B8", "ENSXETT00000027176", "F6W3B8", "ENSXETT00000027176", "species_156540" ] }, "reaction_10327041": { "compartment": "compartment_70101", "id": "reaction_10327041", "reactome": "R-XTR-2744349", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10327038", "catalyst" ] ], "additional_components": [ "ENSXETG00000003389" ] }, "reaction_10327027": { "compartment": "compartment_70101", "id": "reaction_10327027", "reactome": "R-XTR-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10327018", "catalyst" ], [ "species_10327023", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "A0A6I8SNU5", "ENSXETG00000031444", "A0A6I8SCS5", "ENSXETG00000034667", "A0A6I8PYE3", "ENSXETG00000031447", "ENSXETG00000039090" ] }, "reaction_10329555": { "compartment": "compartment_876", "id": "reaction_10329555", "reactome": "R-XTR-5333671", "name": "CLCAs self cleave", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329542" ], "products": [ "species_10327023", "species_10329548" ], "modifiers": [ [ "species_10329542", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "ENSXETG00000039090", "ENSXETG00000039090", "ENSXETG00000039090", "ENSXETG00000039090" ] }, "reaction_10327059": { "compartment": "compartment_17927", "id": "reaction_10327059", "reactome": "R-XTR-2889070", "name": "SLC9B2 exchanges Na+, Li+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_2889081" ], "products": [ "species_2889062", "species_163953" ], "modifiers": [ [ "species_10327056", "catalyst" ] ], "additional_components": [ "species_74113", "species_8953505", "species_8953505", "species_74113", "ENSXETG00000021321" ] }, "reaction_10325871": { "compartment": "compartment_12045", "id": "reaction_10325871", "reactome": "R-XTR-2046083", "name": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046053", "species_113601" ], "products": [ "species_113519", "species_162743", "species_159751", "species_2046060" ], "modifiers": [ [ "species_10319021", "catalyst" ] ], "additional_components": [ "ENSXETT00000034904" ] }, "reaction_10325880": { "compartment": "compartment_17957", "id": "reaction_10325880", "reactome": "R-XTR-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_113519", "species_113564", "species_162743", "species_159751", "species_2046045" ], "modifiers": [ [ "species_10319021", "catalyst" ] ], "additional_components": [ "ENSXETT00000034904" ] }, "reaction_10325878": { "compartment": "compartment_12045", "id": "reaction_10325878", "reactome": "R-XTR-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_5228339", "species_2046055", "species_211606" ], "modifiers": [ [ "species_10317279", "catalyst" ] ], "additional_components": [ "ENSXETG00000007705" ] }, "reaction_10320759": { "compartment": "compartment_876", "id": "reaction_10320759", "reactome": "R-XTR-975449", "name": "GABRR pentamers:GABA transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10320756", "catalyst" ] ], "additional_components": [ "species_428571", "A0A6I8QVR1", "ENSXETG00000030855" ] }, "reaction_10320748": { "compartment": "compartment_876", "id": "reaction_10320748", "reactome": "R-XTR-975311", "name": "HTR3 pentamers:5HT transport Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_74112", "species_74113" ], "products": [ "species_29804", "species_83910", "species_74016" ], "modifiers": [ [ "species_10320745", "catalyst" ] ], "additional_components": [ "species_114523", "A0A6I8QAS1", "ENSXETG00000031115", "A0A6I8RJM1", "ENSXETG00000031022" ] }, "reaction_10338012": { "compartment": "compartment_876", "id": "reaction_10338012", "reactome": "R-XTR-9648983", "name": "HTR3A pentamer:5HT transports Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_74112", "species_74113" ], "products": [ "species_29804", "species_83910", "species_74016" ], "modifiers": [ [ "species_10338009", "catalyst" ] ], "additional_components": [ "A0A6I8QAS1", "ENSXETG00000031115", "species_114523" ] }, "reaction_10337600": { "compartment": "compartment_7660", "id": "reaction_10337600", "reactome": "R-XTR-9029434", "name": "p-S363,S380,T573 RS6K translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337590" ], "products": [ "species_10337598" ], "modifiers": [], "additional_components": [ "F7DTA9", "ENSXETT00000051850", "F6YXI9", "ENSXETT00000008599", "F6YXI9", "ENSXETT00000008599", "F7DTA9", "ENSXETT00000051850" ] }, "reaction_10338016": { "compartment": "compartment_876", "id": "reaction_10338016", "reactome": "R-XTR-9649108", "name": "HTR3A pentamer binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10338014" ], "products": [ "species_10338009" ], "modifiers": [], "additional_components": [ "A0A6I8QAS1", "ENSXETG00000031115", "A0A6I8QAS1", "ENSXETG00000031115", "species_114523" ] }, "reaction_10316794": { "compartment": "compartment_374932", "id": "reaction_10316794", "reactome": "R-XTR-372542", "name": "Loading of dopamine into synaptic veiscles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159362" ], "products": [ "species_351601" ], "modifiers": [ [ "species_10316791", "catalyst" ] ], "additional_components": [ "ENSXETG00000038313" ] }, "reaction_10317198": { "compartment": "compartment_374932", "id": "reaction_10317198", "reactome": "R-XTR-380586", "name": "loading of Serotonin in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209914" ], "products": [ "species_380585" ], "modifiers": [ [ "species_10316791", "catalyst" ] ], "additional_components": [ "ENSXETG00000038313" ] }, "reaction_10333989": { "compartment": "compartment_161320", "id": "reaction_10333989", "reactome": "R-XTR-6803753", "name": "NAAA hydrolyses NAEs to FAs and ethanolamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6803725" ], "products": [ "species_6803745", "species_6803778" ], "modifiers": [ [ "species_10333986", "catalyst" ] ], "additional_components": [ "CHEBI:71466", "CHEBI:2700", "CHEBI:85299", "CHEBI:85263", "CHEBI:71464", "CHEBI:85262", "species_3632881", "CHEBI:30805", "CHEBI:9254", "CHEBI:28875", "CHEBI:16196", "species_140356", "Q6DJ82", "ENSXETT00000057513" ] }, "reaction_10320187": { "compartment": "compartment_917757", "id": "reaction_10320187", "reactome": "R-XTR-888577", "name": "Synthesis of GABA by GAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10320184", "catalyst" ] ], "additional_components": [ "F6YRI6", "ENSXETT00000012900" ] }, "reaction_10320192": { "compartment": "compartment_70101", "id": "reaction_10320192", "reactome": "R-XTR-888592", "name": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352011" ], "products": [ "species_428571" ], "modifiers": [ [ "species_10320189", "catalyst" ] ], "additional_components": [ "ENSXETT00000054324" ] }, "reaction_10316559": { "compartment": "compartment_876", "id": "reaction_10316559", "reactome": "R-XTR-212642", "name": "L-Glutamine transport into neurons", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_212615", "species_74113" ], "products": [ "species_83910", "species_29472" ], "modifiers": [ [ "species_10316556", "catalyst" ] ], "additional_components": [ "ENSXETG00000014662" ] }, "reaction_10316154": { "compartment": "compartment_70101", "id": "reaction_10316154", "reactome": "R-XTR-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_10316149" ], "products": [ "species_10316151" ], "modifiers": [ [ "species_10316149", "catalyst" ] ], "additional_components": [ "Q28H43", "ENSXETT00000090296", "Q05B21", "ENSXETT00000082042", "A0A6I8Q031", "ENSXETG00000008255", "Q28H43", "ENSXETT00000090296", "Q05B21", "ENSXETT00000082042", "species_210382", "A0A6I8Q031", "ENSXETG00000008255", "Q28H43", "ENSXETT00000090296", "Q05B21", "ENSXETT00000082042", "A0A6I8Q031", "ENSXETG00000008255" ] }, "reaction_10316115": { "compartment": "compartment_984", "id": "reaction_10316115", "reactome": "R-XTR-210404", "name": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_210382", "species_29804", "species_74113" ], "products": [ "species_74126", "species_29404", "species_70106", "species_83910" ], "modifiers": [ [ "species_10316108", "catalyst" ], [ "species_10316113", "inhibitor" ] ], "additional_components": [ "ENSXETG00000011685", "ENSXETT00000102749" ] }, "reaction_10316133": { "compartment": "compartment_984", "id": "reaction_10316133", "reactome": "R-XTR-210420", "name": "Ca2+ influx through voltage gated Ca2+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10316130", "catalyst" ], [ "species_74126", "inhibitor" ] ], "additional_components": [ "A0A6I8PYQ9", "ENSXETG00000021694", "A0A6I8SXZ7", "ENSXETG00000005585" ] }, "reaction_10337901": { "compartment": "compartment_876", "id": "reaction_10337901", "reactome": "R-XTR-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9634838", "species_10316781" ], "products": [ "species_10316784" ], "modifiers": [], "additional_components": [ "A0A6I8Q0V4", "ENSXETG00000030902", "A0A5G3JDL4", "ENSXETT00000103127", "A0A6I8Q0V4", "ENSXETG00000030902", "A0A5G3JDL4", "ENSXETT00000103127" ] }, "reaction_10317200": { "compartment": "compartment_5460", "id": "reaction_10317200", "reactome": "R-XTR-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_380598" ], "products": [ "species_113529", "species_380593", "species_29362" ], "modifiers": [ [ "species_10311857", "catalyst" ] ], "additional_components": [ "A0A6I8RHR6", "ENSXETG00000020930" ] }, "reaction_10317171": { "compartment": "compartment_70101", "id": "reaction_10317171", "reactome": "R-XTR-379464", "name": "COMT transfers Met to DOPAC to form HVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9677997", "species_71284" ], "products": [ "species_9677992", "species_174369" ], "modifiers": [ [ "species_10317160", "catalyst" ] ], "additional_components": [ "ENSXETT00000064849" ] }, "reaction_10317165": { "compartment": "compartment_70101", "id": "reaction_10317165", "reactome": "R-XTR-379387", "name": "COMT transfers Met to DA to form 3MT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_159362" ], "products": [ "species_8954997", "species_71285" ], "modifiers": [ [ "species_10317160", "catalyst" ], [ "species_10317163", "inhibitor" ] ], "additional_components": [ "ENSXETT00000064849", "A9UMU1", "ENSXETT00000064849" ] }, "reaction_10336969": { "compartment": "compartment_70101", "id": "reaction_10336969", "reactome": "R-XTR-8955010", "name": "LRTOMT transfers Met to DA, forming 3MT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_159362" ], "products": [ "species_8954997", "species_71285" ], "modifiers": [ [ "species_10336966", "catalyst" ] ], "additional_components": [ "ENSXETG00000039768" ] }, "reaction_10338104": { "compartment": "compartment_876", "id": "reaction_10338104", "reactome": "R-XTR-9679775", "name": "COMT binds COMT Inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317160", "species_9679778" ], "products": [ "species_10317163" ], "modifiers": [], "additional_components": [ "ENSXETT00000064849", "A9UMU1", "ENSXETT00000064849" ] }, "reaction_10316786": { "compartment": "compartment_984", "id": "reaction_10316786", "reactome": "R-XTR-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10316781", "catalyst" ], [ "species_10316784", "inhibitor" ] ], "additional_components": [ "A0A6I8Q0V4", "ENSXETG00000030902", "A0A5G3JDL4", "ENSXETT00000103127", "A0A6I8Q0V4", "ENSXETG00000030902", "A0A5G3JDL4", "ENSXETT00000103127" ] }, "reaction_10316552": { "compartment": "compartment_984", "id": "reaction_10316552", "reactome": "R-XTR-212614", "name": "Glutamine transport from astrocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472" ], "products": [ "species_212615" ], "modifiers": [ [ "species_10316549", "catalyst" ] ], "additional_components": [ "ENSXETG00000041195" ] }, "reaction_10311522": { "compartment": "compartment_70101", "id": "reaction_10311522", "reactome": "R-XTR-70606", "name": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113592", "species_31633" ], "products": [ "species_29372", "species_29370", "species_29472" ], "modifiers": [ [ "species_10311519", "catalyst" ] ], "additional_components": [ "F6VAG8", "ENSXETT00000027374" ] }, "reaction_10338094": { "compartment": "compartment_70101", "id": "reaction_10338094", "reactome": "R-XTR-9679029", "name": "C-ter TLR7 dimer binds HCQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338090", "species_9678628" ], "products": [ "species_10338092" ], "modifiers": [], "additional_components": [ "F7EDI8", "ENSXETT00000013094", "F7EDI8", "ENSXETT00000013094" ] }, "reaction_10313351": { "compartment": "compartment_70101", "id": "reaction_10313351", "reactome": "R-XTR-168166", "name": "NFkB complex is transported from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313343" ], "products": [ "species_10313349" ], "modifiers": [], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173" ] }, "reaction_10312161": { "compartment": "compartment_7660", "id": "reaction_10312161", "reactome": "R-XTR-75998", "name": "Formation of RAD52 heptameric ring structure complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312157" ], "products": [ "species_10312159" ], "modifiers": [], "additional_components": [ "ENSXETG00000009413", "A0A6I8RDE5", "ENSXETG00000009413" ] }, "reaction_10337038": { "compartment": "compartment_70101", "id": "reaction_10337038", "reactome": "R-XTR-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317378", "species_10312717" ], "products": [ "species_10317376", "species_10317380" ], "modifiers": [], "additional_components": [ "A0A6I8T271", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10330050": { "compartment": "compartment_70101", "id": "reaction_10330050", "reactome": "R-XTR-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10317380" ], "products": [ "species_29370", "species_10329598", "species_10312717" ], "modifiers": [ [ "species_10317380", "catalyst" ] ], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8T271", "ENSXETG00000011808", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10314369": { "compartment": "compartment_947587", "id": "reaction_10314369", "reactome": "R-XTR-198266", "name": "PI3K produces PIP3 and other phosphatidyl inositides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10314366", "catalyst" ] ], "additional_components": [ "A0A6I8RAF1", "ENSXETG00000039550", "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252" ] }, "reaction_10337673": { "compartment": "compartment_876", "id": "reaction_10337673", "reactome": "R-XTR-9034714", "name": "NTRK3 dimers trans-autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10337661" ], "products": [ "species_10337670", "species_29370" ], "modifiers": [ [ "species_10337661", "catalyst" ] ], "additional_components": [ "F6VUP1", "ENSXETT00000036251", "A0A6I8T1S6", "ENSXETG00000033787", "F6VUP1", "ENSXETT00000036251", "A0A6I8T1S6", "ENSXETG00000033787", "F6VUP1", "ENSXETT00000036251", "A0A6I8T1S6", "ENSXETG00000033787" ] }, "reaction_10334500": { "compartment": "compartment_12045", "id": "reaction_10334500", "reactome": "R-XTR-6807055", "name": "DHCR7 reduces 7-dehydroCHOL to CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6807057", "species_29364" ], "products": [ "species_193384", "species_29366" ], "modifiers": [ [ "species_10314334", "catalyst" ] ], "additional_components": [ "ENSXETG00000008945" ] }, "reaction_10334502": { "compartment": "compartment_12045", "id": "reaction_10334502", "reactome": "R-XTR-6807064", "name": "DHCR24 reduces ZYMOL to ZYMSTNL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194691" ], "products": [ "species_6807048", "species_29366" ], "modifiers": [ [ "species_10314341", "catalyst" ] ], "additional_components": [ "ENSXETG00000020010" ] }, "reaction_10334498": { "compartment": "compartment_12045", "id": "reaction_10334498", "reactome": "R-XTR-6807053", "name": "SC5D desaturates LTHSOL to 7-dehydroCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6807054", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_6807057" ], "modifiers": [ [ "species_10314319", "catalyst" ] ], "additional_components": [ "ENSXETG00000040073" ] }, "reaction_10332459": { "compartment": "compartment_7660", "id": "reaction_10332459", "reactome": "R-XTR-6797090", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10332455", "species_10312628" ], "products": [ "species_10332457" ], "modifiers": [], "additional_components": [ "ENSXETG00000023695", "ENSXETT00000049621", "F7CLE9", "ENSXETT00000049621", "B5DE93", "ENSXETG00000023695" ] }, "reaction_10332465": { "compartment": "compartment_7660", "id": "reaction_10332465", "reactome": "R-XTR-6797100", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312628", "species_10332461" ], "products": [ "species_10332463" ], "modifiers": [], "additional_components": [ "ENSXETT00000049621", "ENSXETG00000023695", "B5DE93", "ENSXETG00000023695", "F7CLE9", "ENSXETT00000049621" ] }, "reaction_10314021": { "compartment": "compartment_7660", "id": "reaction_10314021", "reactome": "R-XTR-187934", "name": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313994", "species_10313486" ], "products": [ "species_10314013" ], "modifiers": [ [ "species_10313994", "catalyst" ] ], "additional_components": [ "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130", "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125", "ENSXETG00000038125" ] }, "reaction_10330057": { "compartment": "compartment_70101", "id": "reaction_10330057", "reactome": "R-XTR-5628905", "name": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30533" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10330054", "catalyst" ] ], "additional_components": [ "ENSXETG00000005971" ] }, "reaction_10330082": { "compartment": "compartment_70101", "id": "reaction_10330082", "reactome": "R-XTR-5632738", "name": "DDIT4 binds 14-3-3 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312804", "species_10330078" ], "products": [ "species_10330080" ], "modifiers": [], "additional_components": [ "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830", "ENSXETT00000083124", "Q6P4J6", "ENSXETT00000083124", "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830" ] }, "reaction_10333927": { "compartment": "compartment_74700", "id": "reaction_10333927", "reactome": "R-XTR-6801195", "name": "STEAP3 binds BNIP3L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333923", "species_10320592" ], "products": [ "species_10333925" ], "modifiers": [], "additional_components": [ "ENSXETT00000022422", "ENSXETT00000016208", "F6YGT5", "ENSXETT00000016208", "F7AAW4", "ENSXETT00000022422" ] }, "reaction_10333915": { "compartment": "compartment_70101", "id": "reaction_10333915", "reactome": "R-XTR-6800793", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333911" ], "products": [ "species_10333913" ], "modifiers": [], "additional_components": [ "ENSXETG00000033984", "ENSXETG00000033984" ] }, "reaction_10320843": { "compartment": "compartment_70101", "id": "reaction_10320843", "reactome": "R-XTR-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_29372", "species_200736" ], "modifiers": [ [ "species_10320840", "catalyst" ] ], "additional_components": [ "species_109496", "A0A6I8R2I0", "ENSXETG00000041151" ] }, "reaction_10335757": { "compartment": "compartment_876", "id": "reaction_10335757", "reactome": "R-XTR-8866269", "name": "ARRB bind GPCRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335751", "species_10335753" ], "products": [ "species_10335755" ], "modifiers": [], "additional_components": [ "F6SUX3", "ENSXETT00000050169", "F6SKI7", "ENSXETT00000021189", "F6SUX3", "ENSXETT00000050169", "F6SKI7", "ENSXETT00000021189" ] }, "reaction_10338108": { "compartment": "compartment_70101", "id": "reaction_10338108", "reactome": "R-XTR-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9648300", "species_10335334" ], "products": [ "species_10335769" ], "modifiers": [], "additional_components": [ "A0A6I8RNH9", "ENSXETG00000013480", "A0A6I8PJR6", "ENSXETG00000009033", "Q6P856", "ENSXETG00000017276", "A0A6I8RNH9", "ENSXETG00000013480", "A0A6I8PJR6", "ENSXETG00000009033", "Q6P856", "ENSXETG00000017276" ] }, "reaction_10335647": { "compartment": "compartment_876", "id": "reaction_10335647", "reactome": "R-XTR-8863463", "name": "STON2 binds SYT proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335633", "species_10335643" ], "products": [ "species_10335645" ], "modifiers": [], "additional_components": [ "A0A6I8PYV5", "ENSXETG00000034334", "A0A6I8SQ61", "ENSXETG00000038939", "A0A6I8SQ61", "ENSXETG00000038939", "A0A6I8PYV5", "ENSXETG00000034334" ] }, "reaction_10335771": { "compartment": "compartment_876", "id": "reaction_10335771", "reactome": "R-XTR-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335334", "species_10335765" ], "products": [ "species_10335767" ], "modifiers": [ [ "species_10335769", "inhibitor" ] ], "additional_components": [ "A0A6I8RNH9", "ENSXETG00000013480", "A0A6I8PJR6", "ENSXETG00000009033", "Q6P856", "ENSXETG00000017276", "F7BD23", "ENSXETT00000017485", "A0A6I8QYZ2", "ENSXETG00000039705", "A0A6I8QZE2", "ENSXETG00000040690", "species_912516", "Q501K5", "ENSXETG00000011814", "A0A6I8QXB4", "ENSXETG00000021138", "F7BD23", "ENSXETT00000017485", "A0A6I8QYZ2", "ENSXETG00000039705", "A0A6I8QZE2", "ENSXETG00000040690", "species_912516", "Q501K5", "ENSXETG00000011814", "A0A6I8QXB4", "ENSXETG00000021138", "A0A6I8RNH9", "ENSXETG00000013480", "A0A6I8PJR6", "ENSXETG00000009033", "Q6P856", "ENSXETG00000017276", "A0A6I8RNH9", "ENSXETG00000013480", "A0A6I8PJR6", "ENSXETG00000009033", "Q6P856", "ENSXETG00000017276" ] }, "reaction_10335824": { "compartment": "compartment_876", "id": "reaction_10335824", "reactome": "R-XTR-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335810", "species_10335820" ], "products": [ "species_10335822" ], "modifiers": [], "additional_components": [ "ENSXETG00000008255", "A0A6I8Q6S5", "ENSXETG00000032563", "A0A6I8Q6S5", "ENSXETG00000032563", "A0A6I8Q031", "ENSXETG00000008255" ] }, "reaction_10335841": { "compartment": "compartment_876", "id": "reaction_10335841", "reactome": "R-XTR-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10323969", "catalyst" ] ], "additional_components": [ "ENSXETT00000042073" ] }, "reaction_10327264": { "compartment": "compartment_70101", "id": "reaction_10327264", "reactome": "R-XTR-3134804", "name": "STING ubiquitination by TRIM32 or TRIM56", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324513", "species_10312116" ], "products": [ "species_10327258", "species_10324511" ], "modifiers": [ [ "species_10324513", "catalyst" ] ], "additional_components": [ "A0A6I8SBS8", "ENSXETG00000039978", "A8E5V9", "ENSXETG00000016088", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "ENSXETG00000016088", "ENSXETG00000039978", "A0A6I8SBS8", "ENSXETG00000039978", "A8E5V9", "ENSXETG00000016088" ] }, "reaction_10324515": { "compartment": "compartment_70101", "id": "reaction_10324515", "reactome": "R-XTR-1964496", "name": "STING binds TRIM32 or TRIM56 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324507", "species_10324511" ], "products": [ "species_10324513" ], "modifiers": [], "additional_components": [ "ENSXETG00000016088", "ENSXETG00000039978", "A0A6I8SBS8", "ENSXETG00000039978", "A8E5V9", "ENSXETG00000016088" ] }, "reaction_10316740": { "compartment": "compartment_876", "id": "reaction_10316740", "reactome": "R-XTR-352108", "name": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352091", "species_74113" ], "products": [ "species_352088", "species_83910" ], "modifiers": [ [ "species_10316556", "catalyst" ] ], "additional_components": [ "species_29432", "species_29472", "species_379717", "CHEBI:57926", "species_200736", "CHEBI:58048", "species_159549", "species_29588", "species_174390", "species_29472", "species_159549", "species_379717", "species_200736", "CHEBI:57926", "species_29588", "species_174390", "species_29432", "CHEBI:58048", "ENSXETG00000014662" ] }, "reaction_10316756": { "compartment": "compartment_876", "id": "reaction_10316756", "reactome": "R-XTR-352232", "name": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352229" ], "products": [ "species_352227" ], "modifiers": [ [ "species_10316753", "catalyst" ] ], "additional_components": [ "species_29500", "CHEBI:58045", "species_29612", "species_29588", "species_174390", "CHEBI:58315", "species_351993", "CHEBI:57762", "CHEBI:58315", "species_29588", "species_174390", "CHEBI:58045", "CHEBI:57762", "species_29612", "species_29500", "species_351993", "B5DDZ9", "ENSXETT00000061667", "F6YKM8", "ENSXETT00000042158" ] }, "reaction_10316743": { "compartment": "compartment_876", "id": "reaction_10316743", "reactome": "R-XTR-352119", "name": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352123", "species_74113" ], "products": [ "species_352105", "species_83910" ], "modifiers": [ [ "species_10316549", "catalyst" ] ], "additional_components": [ "species_29432", "species_29472", "species_200736", "CHEBI:58048", "species_174390", "species_29472", "species_200736", "species_174390", "species_29432", "CHEBI:58048", "ENSXETG00000041195" ] }, "reaction_10317169": { "compartment": "compartment_876", "id": "reaction_10317169", "reactome": "R-XTR-379426", "name": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_351964", "species_74113" ], "products": [ "species_351977", "species_83910", "species_29588" ], "modifiers": [ [ "species_10317013", "catalyst" ] ], "additional_components": [ "F6YKM8", "ENSXETT00000042158", "Q28I80", "ENSXETT00000014625" ] }, "reaction_10316738": { "compartment": "compartment_876", "id": "reaction_10316738", "reactome": "R-XTR-352107", "name": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352101" ], "products": [ "species_352114" ], "modifiers": [ [ "species_10316735", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "species_29588", "species_174390", "species_351993", "CHEBI:57762", "species_29588", "species_174390", "CHEBI:58045", "CHEBI:57762", "species_351993", "ENSXETG00000022279" ] }, "reaction_10317920": { "compartment": "compartment_876", "id": "reaction_10317920", "reactome": "R-XTR-425678", "name": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_74016", "species_74113" ], "products": [ "species_74126", "species_83910", "species_74112" ], "modifiers": [ [ "species_10317917", "catalyst" ] ], "additional_components": [ "ENSXETG00000010290" ] }, "reaction_10335224": { "compartment": "compartment_70101", "id": "reaction_10335224", "reactome": "R-XTR-8855062", "name": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162252", "species_71284" ], "products": [ "species_2162265", "species_71285" ], "modifiers": [ [ "species_10335221", "catalyst" ] ], "additional_components": [ "ENSXETG00000026858" ] }, "reaction_10317940": { "compartment": "compartment_876", "id": "reaction_10317940", "reactome": "R-XTR-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10317937", "catalyst" ] ], "additional_components": [ "A0A6I8PNM9", "ENSXETG00000033166", "A0A6I8S3I9", "ENSXETG00000040616" ] }, "reaction_10317927": { "compartment": "compartment_172574", "id": "reaction_10317927", "reactome": "R-XTR-425965", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425999", "species_83910" ], "products": [ "species_425977", "species_70106" ], "modifiers": [ [ "species_10317924", "catalyst" ] ], "additional_components": [ "ENSXETT00000029654" ] }, "reaction_10318058": { "compartment": "compartment_876", "id": "reaction_10318058", "reactome": "R-XTR-428015", "name": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428027", "species_29804", "species_74113" ], "products": [ "species_74126", "species_427997", "species_70106", "species_83910" ], "modifiers": [ [ "species_10316108", "catalyst" ] ], "additional_components": [ "species_29448", "species_6810061", "species_210382", "species_29448", "species_6810061", "species_210382", "ENSXETG00000011685" ] }, "reaction_10318141": { "compartment": "compartment_876", "id": "reaction_10318141", "reactome": "R-XTR-429749", "name": "SLC5A8 transports monocarboxylates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429739", "species_74113" ], "products": [ "species_83910", "species_429748" ], "modifiers": [ [ "species_10318138", "catalyst" ] ], "additional_components": [ "species_29398", "species_373863", "CHEBI:32544", "species_76179", "species_29416", "CHEBI:30768", "species_76179", "species_29398", "species_29416", "species_373863", "CHEBI:30768", "CHEBI:15940", "ENSXETG00000031274" ] }, "reaction_10318063": { "compartment": "compartment_201753", "id": "reaction_10318063", "reactome": "R-XTR-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_428548" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10318060", "catalyst" ] ], "additional_components": [ "ENSXETT00000082042" ] }, "reaction_10318144": { "compartment": "compartment_876", "id": "reaction_10318144", "reactome": "R-XTR-429767", "name": "Passive I- efflux mediated by SMCT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10318138", "catalyst" ] ], "additional_components": [ "ENSXETG00000031274" ] }, "reaction_10318084": { "compartment": "compartment_201753", "id": "reaction_10318084", "reactome": "R-XTR-428625", "name": "Vesicular inhibitory amino acid transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428592", "species_428548" ], "products": [ "species_428632", "species_70106" ], "modifiers": [ [ "species_10318081", "catalyst" ] ], "additional_components": [ "species_159549", "species_428571", "species_428571", "species_159549", "ENSXETT00000054324" ] }, "reaction_10318014": { "compartment": "compartment_876", "id": "reaction_10318014", "reactome": "R-XTR-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10318011", "catalyst" ] ], "additional_components": [ "ENSXETG00000005947" ] }, "reaction_10335952": { "compartment": "compartment_70101", "id": "reaction_10335952", "reactome": "R-XTR-8876312", "name": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8876310", "species_74113" ], "products": [ "species_83910", "species_8876304" ], "modifiers": [ [ "species_10335949", "catalyst" ] ], "additional_components": [ "species_29398", "species_373863", "CHEBI:32544", "species_29398", "species_373863", "CHEBI:15940", "ENSXETG00000025601" ] }, "reaction_10318034": { "compartment": "compartment_876", "id": "reaction_10318034", "reactome": "R-XTR-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_111627" ], "products": [ "species_425425", "species_352022" ], "modifiers": [ [ "species_10318031", "catalyst" ] ], "additional_components": [ "ENSXETG00000016188" ] }, "reaction_10318027": { "compartment": "compartment_876", "id": "reaction_10318027", "reactome": "R-XTR-427605", "name": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10318024", "catalyst" ] ], "additional_components": [ "Q28E01", "ENSXETG00000009532", "Q5BL44", "ENSXETT00000041138" ] }, "reaction_10312261": { "compartment": "compartment_7660", "id": "reaction_10312261", "reactome": "R-XTR-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312257", "species_10312253" ], "products": [ "species_10312259" ], "modifiers": [], "additional_components": [ "ENSXETG00000010179", "ENSXETT00000041997", "Q6DES0", "ENSXETT00000041997", "Q6DIE2", "ENSXETG00000010179" ] }, "reaction_10318606": { "compartment": "compartment_70101", "id": "reaction_10318606", "reactome": "R-XTR-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450523", "species_10318588" ], "products": [ "species_10318590" ], "modifiers": [], "additional_components": [ "ENSXETG00000030723", "A0A6I8SGT0", "ENSXETG00000030723" ] }, "reaction_10318952": { "compartment": "compartment_70101", "id": "reaction_10318952", "reactome": "R-XTR-482788", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312800", "species_10318596" ], "products": [ "species_10318950" ], "modifiers": [], "additional_components": [ "ENSXETG00000022830", "A0A6I8SGT0", "ENSXETG00000030723", "A0A6I8SGT0", "ENSXETG00000030723", "Q5XGC8", "ENSXETG00000022830" ] }, "reaction_10318586": { "compartment": "compartment_70101", "id": "reaction_10318586", "reactome": "R-XTR-450406", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312800", "species_10318582" ], "products": [ "species_10318584" ], "modifiers": [], "additional_components": [ "ENSXETG00000022830", "A0A6I8SGT0", "ENSXETG00000030723", "A0A6I8SGT0", "ENSXETG00000030723", "Q5XGC8", "ENSXETG00000022830" ] }, "reaction_10318604": { "compartment": "compartment_7660", "id": "reaction_10318604", "reactome": "R-XTR-450494", "name": "HuR binds mRNAs in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318600", "species_450613" ], "products": [ "species_10318602" ], "modifiers": [], "additional_components": [ "ENSXETG00000008752", "Q6GLB5", "ENSXETG00000008752" ] }, "reaction_10319007": { "compartment": "compartment_7660", "id": "reaction_10319007", "reactome": "R-XTR-517705", "name": "p-S318,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318610", "species_517622" ], "products": [ "species_10319005" ], "modifiers": [], "additional_components": [ "ENSXETG00000008752", "Q6GLB5", "ENSXETG00000008752" ] }, "reaction_10319003": { "compartment": "compartment_7660", "id": "reaction_10319003", "reactome": "R-XTR-517674", "name": "p-S158,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450605", "species_10318613" ], "products": [ "species_10319001" ], "modifiers": [], "additional_components": [ "ENSXETG00000008752", "Q6GLB5", "ENSXETG00000008752" ] }, "reaction_10314047": { "compartment": "compartment_984", "id": "reaction_10314047", "reactome": "R-XTR-188979", "name": "Digestion of linear starch (amylose) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189075" ], "products": [ "species_191103", "species_188986" ], "modifiers": [ [ "species_10314044", "catalyst" ] ], "additional_components": [ "species_70113", "ENSXETG00000010847" ] }, "reaction_10314056": { "compartment": "compartment_984", "id": "reaction_10314056", "reactome": "R-XTR-189062", "name": "lactose + H2O => D-glucose + D-galactose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188973", "species_109276" ], "products": [ "species_70115", "species_188995" ], "modifiers": [ [ "species_10314053", "catalyst" ] ], "additional_components": [ "A0A6I8SYH9", "ENSXETG00000025031" ] }, "reaction_10314145": { "compartment": "compartment_984", "id": "reaction_10314145", "reactome": "R-XTR-191114", "name": "Digestion of branched starch (amylopectin) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189071" ], "products": [ "species_191103", "species_188986", "species_189108" ], "modifiers": [ [ "species_10314044", "catalyst" ] ], "additional_components": [ "species_70113", "ENSXETG00000010847" ] }, "reaction_10328964": { "compartment": "compartment_7660", "id": "reaction_10328964", "reactome": "R-XTR-4755536", "name": "PIAS3 SUMOylates RELA with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327222", "species_10328953" ], "products": [ "species_10328962", "species_10327128" ], "modifiers": [ [ "species_10328492", "catalyst" ] ], "additional_components": [ "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8PS73", "ENSXETG00000026173", "ENSXETT00000054232", "ENSXETG00000018642" ] }, "reaction_10334705": { "compartment": "compartment_20699", "id": "reaction_10334705", "reactome": "R-XTR-8848484", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_29356" ], "products": [ "species_6814303", "species_8848483" ], "modifiers": [ [ "species_10318101", "catalyst" ] ], "additional_components": [ "ENSXETT00000066288" ] }, "reaction_10335199": { "compartment": "compartment_17938", "id": "reaction_10335199", "reactome": "R-XTR-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10335194" ], "products": [ "species_29372", "species_10335196" ], "modifiers": [ [ "species_10335194", "catalyst" ] ], "additional_components": [ "species_29438", "F7A377", "ENSXETT00000029250", "F7A377", "ENSXETT00000029250", "species_29420", "species_29438", "F7A377", "ENSXETT00000029250" ] }, "reaction_10335189": { "compartment": "compartment_24339", "id": "reaction_10335189", "reactome": "R-XTR-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10335180" ], "products": [ "species_29372", "species_10335182" ], "modifiers": [ [ "species_10335180", "catalyst" ], [ "species_10335187", "catalyst" ] ], "additional_components": [ "Q6P7Z7", "ENSXETT00000056541", "species_29438", "Q6P7Z7", "ENSXETT00000056541", "species_29420", "Q6P7Z7", "ENSXETT00000056541", "species_29438", "ENSXETT00000043751" ] }, "reaction_10335207": { "compartment": "compartment_17938", "id": "reaction_10335207", "reactome": "R-XTR-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10335194" ], "products": [ "species_29372", "species_10335205" ], "modifiers": [ [ "species_10335194", "catalyst" ] ], "additional_components": [ "species_29438", "F7A377", "ENSXETT00000029250", "species_29420", "F7A377", "ENSXETT00000029250", "species_29438", "F7A377", "ENSXETT00000029250" ] }, "reaction_10335984": { "compartment": "compartment_70101", "id": "reaction_10335984", "reactome": "R-XTR-8876446", "name": "p-ULK1 phosphorylates DENND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335969", "species_113592" ], "products": [ "species_29370", "species_10335973" ], "modifiers": [ [ "species_10335981", "catalyst" ] ], "additional_components": [ "ENSXETT00000054527", "ENSXETT00000054527", "ENSXETG00000002028" ] }, "reaction_10318634": { "compartment": "compartment_70101", "id": "reaction_10318634", "reactome": "R-XTR-451056", "name": "Microtubule-independent trafficking of connexons to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318628" ], "products": [ "species_10318632" ], "modifiers": [], "additional_components": [ "Q28ED4", "ENSXETT00000055228", "Q28ED4", "ENSXETT00000055228" ] }, "reaction_10314143": { "compartment": "compartment_12045", "id": "reaction_10314143", "reactome": "R-XTR-190681", "name": "Connexin oligomerization in endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314138" ], "products": [ "species_10314140" ], "modifiers": [ [ "species_10314138", "catalyst" ] ], "additional_components": [ "ENSXETT00000055497", "Q6NVT8", "ENSXETT00000055497", "ENSXETT00000055497" ] }, "reaction_10335934": { "compartment": "compartment_20699", "id": "reaction_10335934", "reactome": "R-XTR-8874979", "name": "ACBD3 binds GOLGB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335924", "species_10335930" ], "products": [ "species_10335932" ], "modifiers": [], "additional_components": [ "ENSXETT00000048980", "A0A6I8PMP5", "ENSXETG00000033340", "A0A6I8PMP5", "ENSXETG00000033340", "F6WGE2", "ENSXETT00000048980" ] }, "reaction_10326647": { "compartment": "compartment_24337", "id": "reaction_10326647", "reactome": "R-XTR-2247512", "name": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326631" ], "products": [ "species_10326645" ], "modifiers": [], "additional_components": [ "species_426658", "species_33625", "CHEBI:28640", "species_2186967", "species_30495", "CHEBI:37671", "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "species_171142", "species_216762", "CHEBI:60479", "CHEBI:64009", "CHEBI:64294", "A0A6I8RKY6", "ENSXETG00000026768", "CHEBI:24654", "A0A6I8S279", "ENSXETG00000037724", "A0A6I8S279", "ENSXETG00000037724", "CHEBI:64294", "CHEBI:60479", "species_171126", "species_171142", "CHEBI:24654", "A0A6I8RKY6", "ENSXETG00000026768", "CHEBI:64009", "species_163579", "species_216762", "CHEBI:28640", "species_426658", "species_30495", "species_2186967", "CHEBI:37671", "A0A6I8PU04", "ENSXETG00000033423", "species_33625" ] }, "reaction_10318182": { "compartment": "compartment_876", "id": "reaction_10318182", "reactome": "R-XTR-434381", "name": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_400452" ], "products": [ "species_3632881" ], "modifiers": [ [ "species_10318179", "catalyst" ] ], "additional_components": [ "ENSXETG00000037724" ] }, "reaction_10329322": { "compartment": "compartment_13231", "id": "reaction_10329322", "reactome": "R-XTR-5223304", "name": "DAG and Ca+2 bind to PKC and tether it to membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329318", "species_5221124", "species_29496" ], "products": [ "species_10329320" ], "modifiers": [], "additional_components": [ "ENSXETG00000017294", "species_74112", "species_114519", "A8KBH6", "ENSXETG00000017294" ] }, "reaction_10326334": { "compartment": "compartment_7660", "id": "reaction_10326334", "reactome": "R-XTR-2172678", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326327", "species_113671", "species_113685" ], "products": [ "species_29478", "species_10326331", "species_159942", "species_159939" ], "modifiers": [ [ "species_10326327", "catalyst" ] ], "additional_components": [ "species_435347", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8RKR7", "ENSXETG00000035354", "species_435347", "species_435347", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10326658": { "compartment": "compartment_7660", "id": "reaction_10326658", "reactome": "R-XTR-2301205", "name": "SETD8 monomethylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10326331" ], "products": [ "species_77502", "species_10326327" ], "modifiers": [ [ "species_10326655", "catalyst" ] ], "additional_components": [ "A0A6I8RKR7", "ENSXETG00000035354", "species_435347", "species_435347", "A0A6I8RKR7", "ENSXETG00000035354", "ENSXETT00000012803" ] }, "reaction_10326218": { "compartment": "compartment_7660", "id": "reaction_10326218", "reactome": "R-XTR-2168079", "name": "MASTL (GWL) phosphorylates ARPP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10326205" ], "products": [ "species_113582", "species_10326208" ], "modifiers": [ [ "species_10326215", "catalyst" ] ], "additional_components": [ "ENSXETG00000027097", "ENSXETG00000027097", "ENSXETG00000018741" ] }, "reaction_10326837": { "compartment": "compartment_7660", "id": "reaction_10326837", "reactome": "R-XTR-2430535", "name": "MASTL phosphorylates ENSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10326832" ], "products": [ "species_113582", "species_10326835" ], "modifiers": [ [ "species_10326215", "catalyst" ] ], "additional_components": [ "ENSXETT00000056121", "ENSXETT00000056121", "ENSXETG00000018741" ] }, "reaction_10337987": { "compartment": "compartment_70101", "id": "reaction_10337987", "reactome": "R-XTR-9647746", "name": "EML4 trimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337983" ], "products": [ "species_10337985" ], "modifiers": [], "additional_components": [ "ENSXETG00000006002", "Q6DIP5", "ENSXETG00000006002" ] }, "reaction_10313138": { "compartment": "compartment_7660", "id": "reaction_10313138", "reactome": "R-XTR-163010", "name": "Down Regulation of Emi1 through Phosphorylation of Emi1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10313127" ], "products": [ "species_113582", "species_10313130" ], "modifiers": [ [ "species_10313135", "catalyst" ] ], "additional_components": [ "ENSXETG00000018545", "ENSXETG00000018545", "ENSXETT00000022754" ] }, "reaction_10337822": { "compartment": "compartment_70101", "id": "reaction_10337822", "reactome": "R-XTR-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9624879", "species_10337818" ], "products": [ "species_10337820" ], "modifiers": [], "additional_components": [ "Q6GL85", "ENSXETG00000027832", "species_29438", "Q6GL85", "ENSXETG00000027832", "species_29438" ] }, "reaction_10313996": { "compartment": "compartment_13231", "id": "reaction_10313996", "reactome": "R-XTR-187506", "name": "Translocation of p27 to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313992" ], "products": [ "species_10313994" ], "modifiers": [], "additional_components": [ "ENSXETG00000038125", "ENSXETG00000038125" ] }, "reaction_10314011": { "compartment": "compartment_7660", "id": "reaction_10314011", "reactome": "R-XTR-187520", "name": "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314003", "species_29358" ], "products": [ "species_113582", "species_10314008" ], "modifiers": [ [ "species_10314003", "catalyst" ] ], "additional_components": [ "A0A6I8SFF7", "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10313473": { "compartment": "compartment_70101", "id": "reaction_10313473", "reactome": "R-XTR-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311363", "species_10313428" ], "products": [ "species_10313471" ], "modifiers": [], "additional_components": [ "ENSXETT00000046130", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10313488": { "compartment": "compartment_13231", "id": "reaction_10313488", "reactome": "R-XTR-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313471" ], "products": [ "species_10313486" ], "modifiers": [], "additional_components": [ "F6T0J1", "ENSXETT00000046130", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10314032": { "compartment": "compartment_7660", "id": "reaction_10314032", "reactome": "R-XTR-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10311391" ], "products": [ "species_113582", "species_10312634" ], "modifiers": [ [ "species_10314001", "catalyst" ] ], "additional_components": [ "ENSXETG00000031493", "ENSXETG00000031493", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10314018": { "compartment": "compartment_7660", "id": "reaction_10314018", "reactome": "R-XTR-187916", "name": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10314013" ], "products": [ "species_113582", "species_10314015" ], "modifiers": [ [ "species_10314013", "catalyst" ] ], "additional_components": [ "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125", "F6T0J1", "ENSXETT00000046130", "A0A6I8SFF7", "ENSXETG00000038125" ] }, "reaction_10311361": { "compartment": "compartment_7660", "id": "reaction_10311361", "reactome": "R-XTR-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311355" ], "products": [ "species_10311333", "species_10311353", "species_10311359", "species_10311341" ], "modifiers": [], "additional_components": [ "Q561P5", "ENSXETG00000000253", "Q6GL41", "ENSXETG00000004854", "Q6DIH3", "ENSXETG00000002059", "Q28BS0", "ENSXETG00000021701", "Q6NX31", "ENSXETT00000074596", "Q6P1V8", "ENSXETG00000014891", "ENSXETG00000021701", "ENSXETG00000002059", "Q6GL41", "ENSXETG00000004854", "Q6NX31", "ENSXETT00000074596", "Q6P1V8", "ENSXETG00000014891", "ENSXETG00000000253" ] }, "reaction_10338031": { "compartment": "compartment_70101", "id": "reaction_10338031", "reactome": "R-XTR-9659820", "name": "RB1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338029" ], "products": [ "species_10311367" ], "modifiers": [], "additional_components": [ "ENSXETG00000031493", "ENSXETG00000031493" ] }, "reaction_10322470": { "compartment": "compartment_7660", "id": "reaction_10322470", "reactome": "R-XTR-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322466", "species_10313486" ], "products": [ "species_10322468" ], "modifiers": [], "additional_components": [ "ENSXETT00000008804", "F6T0J1", "ENSXETT00000046130", "F6T0J1", "ENSXETT00000046130", "F6UBS5", "ENSXETT00000008804" ] }, "reaction_10326109": { "compartment": "compartment_12045", "id": "reaction_10326109", "reactome": "R-XTR-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10326106", "catalyst" ] ], "additional_components": [ "A0A6I8SJ30", "ENSXETG00000038590", "A0A6I8PUP3", "ENSXETG00000033706", "F6W5W2", "ENSXETT00000042586", "A4IGV4", "ENSXETT00000061279" ] }, "reaction_10326121": { "compartment": "compartment_12045", "id": "reaction_10326121", "reactome": "R-XTR-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10326118", "catalyst" ] ], "additional_components": [ "A0A6I8SJ30", "ENSXETG00000038590", "F6W5W2", "ENSXETT00000042586", "A4IGV4", "ENSXETT00000061279" ] }, "reaction_10326104": { "compartment": "compartment_12045", "id": "reaction_10326104", "reactome": "R-XTR-2161795", "name": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2161639" ], "modifiers": [ [ "species_10326101", "catalyst" ] ], "additional_components": [ "CHEBI:63995", "CHEBI:63994", "CHEBI:63579", "A0A6I8SJ30", "ENSXETG00000038590", "A4IGV4", "ENSXETT00000061279" ] }, "reaction_10316618": { "compartment": "compartment_70101", "id": "reaction_10316618", "reactome": "R-XTR-264444", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316611", "species_10312116" ], "products": [ "species_10316615" ], "modifiers": [ [ "species_10316611", "catalyst" ] ], "additional_components": [ "ENSXETG00000009192", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8RXS2", "ENSXETG00000009192", "ENSXETG00000009192" ] }, "reaction_10316613": { "compartment": "compartment_13231", "id": "reaction_10316613", "reactome": "R-XTR-264418", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316609" ], "products": [ "species_10316611" ], "modifiers": [], "additional_components": [ "ENSXETG00000009192", "ENSXETG00000009192" ] }, "reaction_10320461": { "compartment": "compartment_17963", "id": "reaction_10320461", "reactome": "R-XTR-914012", "name": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320438" ], "products": [ "species_10320454", "species_205687" ], "modifiers": [ [ "species_10320458", "catalyst" ] ], "additional_components": [ "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "ENSXETG00000032293" ] }, "reaction_10320365": { "compartment": "compartment_17963", "id": "reaction_10320365", "reactome": "R-XTR-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10320292" ], "products": [ "species_10320363", "species_205687" ], "modifiers": [], "additional_components": [ "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522" ] }, "reaction_10320383": { "compartment": "compartment_17963", "id": "reaction_10320383", "reactome": "R-XTR-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320292" ], "products": [ "species_205687", "species_10320381" ], "modifiers": [], "additional_components": [ "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8R3H8", "ENSXETG00000039522" ] }, "reaction_10320479": { "compartment": "compartment_17963", "id": "reaction_10320479", "reactome": "R-XTR-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10320292" ], "products": [ "species_205687", "species_10320477" ], "modifiers": [], "additional_components": [ "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8R3H8", "ENSXETG00000039522" ] }, "reaction_10331400": { "compartment": "compartment_20699", "id": "reaction_10331400", "reactome": "R-XTR-5694487", "name": "A4GNT transfers GlcNAc to core 2 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320454" ], "products": [ "species_10331393", "species_205687" ], "modifiers": [ [ "species_10331397", "catalyst" ] ], "additional_components": [ "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8R3H8", "ENSXETG00000039522", "ENSXETG00000037302" ] }, "reaction_10320347": { "compartment": "compartment_17963", "id": "reaction_10320347", "reactome": "R-XTR-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320292" ], "products": [ "species_205687", "species_10320345" ], "modifiers": [], "additional_components": [ "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8QTA8", "ENSXETG00000018869" ] }, "reaction_10320327": { "compartment": "compartment_20699", "id": "reaction_10320327", "reactome": "R-XTR-913675", "name": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10320276" ], "products": [ "species_10320292", "species_205687" ], "modifiers": [ [ "species_10320324", "catalyst" ] ], "additional_components": [ "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "Q6DJR8", "ENSXETG00000040522", "A0A6I8SNY2", "ENSXETG00000040522", "F6VQB1", "ENSXETT00000045011", "F6R8Z5", "ENSXETT00000046964" ] }, "reaction_10332295": { "compartment": "compartment_20699", "id": "reaction_10332295", "reactome": "R-XTR-6786012", "name": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10320454" ], "products": [ "species_10332290", "species_742343" ], "modifiers": [ [ "species_10332292", "catalyst" ] ], "additional_components": [ "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "ENSXETG00000040380" ] }, "reaction_10320422": { "compartment": "compartment_20699", "id": "reaction_10320422", "reactome": "R-XTR-914010", "name": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320292" ], "products": [ "species_205687", "species_10320399" ], "modifiers": [ [ "species_10320419", "catalyst" ] ], "additional_components": [ "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8SXK5", "ENSXETG00000040687", "Q6P3P5", "ENSXETT00000055015" ] }, "reaction_10320497": { "compartment": "compartment_20699", "id": "reaction_10320497", "reactome": "R-XTR-914018", "name": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10320399" ], "products": [ "species_205687", "species_10320495" ], "modifiers": [ [ "species_10320458", "catalyst" ] ], "additional_components": [ "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "A0A6I8QYJ7", "ENSXETG00000037294", "ENSXETG00000032293" ] }, "reaction_10316180": { "compartment": "compartment_7660", "id": "reaction_10316180", "reactome": "R-XTR-211178", "name": "Phosphorylated FOXO1A is excluded from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315552" ], "products": [ "species_10316178" ], "modifiers": [], "additional_components": [ "ENSXETT00000101788", "ENSXETT00000101788" ] }, "reaction_10338106": { "compartment": "compartment_70101", "id": "reaction_10338106", "reactome": "R-XTR-9680443", "name": "ROCK1,2 bind ROCKi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9686558", "species_10317786" ], "products": [ "species_10317790" ], "modifiers": [], "additional_components": [ "ENSXETG00000023782", "A0A6I8Q6H0", "ENSXETG00000023782" ] }, "reaction_10317792": { "compartment": "compartment_70101", "id": "reaction_10317792", "reactome": "R-XTR-419049", "name": "ROCK activation by RHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317786", "species_10317689" ], "products": [ "species_10317788" ], "modifiers": [ [ "species_10317790", "inhibitor" ] ], "additional_components": [ "ENSXETG00000023782", "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8Q6H0", "ENSXETG00000023782", "A0A6I8Q6H0", "ENSXETG00000023782" ] }, "reaction_10336907": { "compartment": "compartment_5460", "id": "reaction_10336907", "reactome": "R-XTR-8952903", "name": "ADPRHL2 hydrolyses poly(ADP-ribose)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8952909", "species_113521" ], "products": [ "species_8952909", "species_8952905" ], "modifiers": [ [ "species_10336904", "catalyst" ] ], "additional_components": [ "species_8952905", "species_8952905", "ENSXETG00000004374" ] }, "reaction_10312814": { "compartment": "compartment_70101", "id": "reaction_10312814", "reactome": "R-XTR-139905", "name": "Translocation of activated BAD protein to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312810" ], "products": [ "species_10312812" ], "modifiers": [], "additional_components": [ "ENSXETG00000031875", "ENSXETG00000031875" ] }, "reaction_10312808": { "compartment": "compartment_70101", "id": "reaction_10312808", "reactome": "R-XTR-139899", "name": "Sequestration of BAD protein by 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312790", "species_10312804" ], "products": [ "species_10312806" ], "modifiers": [], "additional_components": [ "ENSXETG00000031875", "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830", "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830", "A0A6I8PXS6", "ENSXETG00000031875" ] }, "reaction_10312632": { "compartment": "compartment_7660", "id": "reaction_10312632", "reactome": "R-XTR-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312624", "species_10312628" ], "products": [ "species_10312630" ], "modifiers": [], "additional_components": [ "ENSXETG00000024742", "ENSXETT00000049621", "F7CLE9", "ENSXETT00000049621", "Q6GLD8", "ENSXETG00000024742" ] }, "reaction_10328189": { "compartment": "compartment_876", "id": "reaction_10328189", "reactome": "R-XTR-3781943", "name": "WLS:WNT complex is internalized for maturation into exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327498" ], "products": [ "species_10328169" ], "modifiers": [], "additional_components": [ "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930", "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930" ] }, "reaction_10327518": { "compartment": "compartment_171062", "id": "reaction_10327518", "reactome": "R-XTR-3247847", "name": "WLS is endocytosed to the early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327484" ], "products": [ "species_10327516" ], "modifiers": [], "additional_components": [ "ENSXETG00000012387", "ENSXETG00000012387" ] }, "reaction_10327512": { "compartment": "compartment_984", "id": "reaction_10327512", "reactome": "R-XTR-3247843", "name": "secretion of WNT ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327498" ], "products": [ "species_10327510", "species_10327484" ], "modifiers": [], "additional_components": [ "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930", "A0A6I8PXW7", "ENSXETG00000031623", "A0A6I8PX82", "ENSXETG00000011173", "A0A6I8QGQ0", "ENSXETG00000039930", "B2GUT4", "ENSXETT00000042046", "A0A6I8R7P2", "ENSXETG00000031217", "ENSXETG00000012387" ] }, "reaction_10328187": { "compartment": "compartment_383505", "id": "reaction_10328187", "reactome": "R-XTR-3781941", "name": "WNTs are secreted in exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328169" ], "products": [ "species_10328185" ], "modifiers": [], "additional_components": [ "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930", "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930" ] }, "reaction_10327482": { "compartment": "compartment_20699", "id": "reaction_10327482", "reactome": "R-XTR-3247840", "name": "WLS binds WNT ligands in the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327472", "species_10327478" ], "products": [ "species_10327480" ], "modifiers": [], "additional_components": [ "A0A6I8QGQ0", "ENSXETG00000039930", "ENSXETG00000012387", "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930" ] }, "reaction_10327514": { "compartment": "compartment_20699", "id": "reaction_10327514", "reactome": "R-XTR-3247844", "name": "WNT ligands traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327480" ], "products": [ "species_10327498" ], "modifiers": [], "additional_components": [ "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930", "A0A6I8PTQ1", "ENSXETG00000012387", "A0A6I8QGQ0", "ENSXETG00000039930" ] }, "reaction_10327474": { "compartment": "compartment_17963", "id": "reaction_10327474", "reactome": "R-XTR-3247837", "name": "WNT ligands traffic to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327460" ], "products": [ "species_10327472" ], "modifiers": [], "additional_components": [ "A0A6I8QGQ0", "ENSXETG00000039930", "A0A6I8QGQ0", "ENSXETG00000039930" ] }, "reaction_10312702": { "compartment": "compartment_17906", "id": "reaction_10312702", "reactome": "R-XTR-114284", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312698" ], "products": [ "species_10312660" ], "modifiers": [ [ "species_10312700", "catalyst" ] ], "additional_components": [ "Q6PBF4", "ENSXETT00000049267", "Q640U4", "ENSXETT00000018532", "Q640U4", "ENSXETT00000018532", "Q6PBF4", "ENSXETT00000049267", "A0A6I8QFQ5", "ENSXETG00000038338", "F6TEC3", "ENSXETT00000031936" ] }, "reaction_10337835": { "compartment": "compartment_70101", "id": "reaction_10337835", "reactome": "R-XTR-9627106", "name": "SMAC (DIABLO) forms dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312709" ], "products": [ "species_10337828" ], "modifiers": [], "additional_components": [ "ENSXETT00000008194", "Q0IJ31", "ENSXETT00000008194" ] }, "reaction_10312711": { "compartment": "compartment_17906", "id": "reaction_10312711", "reactome": "R-XTR-114307", "name": "Release of SMAC (DIABLO) from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312707" ], "products": [ "species_10312709" ], "modifiers": [ [ "species_10312700", "catalyst" ] ], "additional_components": [ "ENSXETT00000008194", "ENSXETT00000008194", "A0A6I8QFQ5", "ENSXETG00000038338", "F6TEC3", "ENSXETT00000031936" ] }, "reaction_10334049": { "compartment": "compartment_70101", "id": "reaction_10334049", "reactome": "R-XTR-6805507", "name": "APAF1 binds AVEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312666", "species_10334045" ], "products": [ "species_10334047" ], "modifiers": [], "additional_components": [ "A0A6I8RCL3", "ENSXETG00000006695", "species_29370", "ENSXETG00000017866", "A0A6I8PLL4", "ENSXETG00000017866", "A0A6I8RCL3", "ENSXETG00000006695", "species_29370" ] }, "reaction_10312672": { "compartment": "compartment_70101", "id": "reaction_10312672", "reactome": "R-XTR-114254", "name": "CYCS binds to APAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10312660", "species_10312666" ], "products": [ "species_29370", "species_10312670" ], "modifiers": [], "additional_components": [ "Q640U4", "ENSXETT00000018532", "Q6PBF4", "ENSXETT00000049267", "A0A6I8RCL3", "ENSXETG00000006695", "species_29370", "A0A6I8RCL3", "ENSXETG00000006695", "species_113593", "Q640U4", "ENSXETT00000018532", "Q6PBF4", "ENSXETT00000049267" ] }, "reaction_10337832": { "compartment": "compartment_70101", "id": "reaction_10337832", "reactome": "R-XTR-9627104", "name": "XIAP binds CASP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312650", "species_10329609" ], "products": [ "species_10337826" ], "modifiers": [ [ "species_10337830", "inhibitor" ] ], "additional_components": [ "A0A6I8PZK4", "ENSXETG00000030678", "ENSXETT00000035327", "Q5BKL8", "ENSXETT00000035327", "A0A6I8PZK4", "ENSXETG00000030678", "Q0IJ31", "ENSXETT00000008194", "Q5BKL8", "ENSXETT00000035327", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10337839": { "compartment": "compartment_70101", "id": "reaction_10337839", "reactome": "R-XTR-9627350", "name": "SMAC (DIABLO) binds XIAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337828", "species_10329609" ], "products": [ "species_10337837" ], "modifiers": [], "additional_components": [ "Q0IJ31", "ENSXETT00000008194", "ENSXETT00000035327", "Q5BKL8", "ENSXETT00000035327", "Q0IJ31", "ENSXETT00000008194" ] }, "reaction_10328555": { "compartment": "compartment_12045", "id": "reaction_10328555", "reactome": "R-XTR-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419981", "species_29364" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10328552", "catalyst" ] ], "additional_components": [ "ENSXETG00000021063" ] }, "reaction_10336283": { "compartment": "compartment_70101", "id": "reaction_10336283", "reactome": "R-XTR-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869353", "species_113592" ], "products": [ "species_1132084", "species_29360" ], "modifiers": [ [ "species_10314359", "catalyst" ] ], "additional_components": [ "species_109496", "A4IH61", "ENSXETT00000027403" ] }, "reaction_10314362": { "compartment": "compartment_70101", "id": "reaction_10314362", "reactome": "R-XTR-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_1132084" ], "modifiers": [ [ "species_10314359", "catalyst" ] ], "additional_components": [ "species_109496", "A4IH61", "ENSXETT00000027403" ] }, "reaction_10335877": { "compartment": "compartment_70101", "id": "reaction_10335877", "reactome": "R-XTR-8869633", "name": "NMRK1 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_8869353", "species_70106", "species_29370" ], "modifiers": [ [ "species_10335871", "catalyst" ] ], "additional_components": [ "ENSXETG00000031505" ] }, "reaction_10329621": { "compartment": "compartment_70101", "id": "reaction_10329621", "reactome": "R-XTR-5359451", "name": "NNMT transfers CH3 from SAM to NAM to form MNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197277", "species_71284" ], "products": [ "species_549282", "species_71285" ], "modifiers": [ [ "species_10313553", "catalyst" ] ], "additional_components": [ "ENSXETG00000028049" ] }, "reaction_10336214": { "compartment": "compartment_70101", "id": "reaction_10336214", "reactome": "R-XTR-8938073", "name": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938276", "species_29360" ], "products": [ "species_197277", "species_8938282" ], "modifiers": [ [ "species_10336211", "catalyst" ] ], "additional_components": [ "A0A1B8XUU3", "ENSXETT00000078735", "F6YMQ2", "ENSXETT00000038413" ] }, "reaction_10334496": { "compartment": "compartment_5460", "id": "reaction_10334496", "reactome": "R-XTR-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10334493", "catalyst" ] ], "additional_components": [ "A0A5S6NBZ0", "ENSXETG00000020391" ] }, "reaction_10335874": { "compartment": "compartment_70101", "id": "reaction_10335874", "reactome": "R-XTR-8869606", "name": "NMRK1 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10335871", "catalyst" ] ], "additional_components": [ "ENSXETG00000031505" ] }, "reaction_10336978": { "compartment": "compartment_5460", "id": "reaction_10336978", "reactome": "R-XTR-8955030", "name": "NADK2 dimer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113526" ], "products": [ "species_113581", "species_113563", "species_113529" ], "modifiers": [ [ "species_10336975", "catalyst" ] ], "additional_components": [ "Q08CZ6", "ENSXETT00000010405" ] }, "reaction_10314353": { "compartment": "compartment_70101", "id": "reaction_10314353", "reactome": "R-XTR-196955", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29386" ], "products": [ "species_73524", "species_76577" ], "modifiers": [ [ "species_10314350", "catalyst" ] ], "additional_components": [ "A0A6I8RYX5", "ENSXETG00000030043" ] }, "reaction_10315543": { "compartment": "compartment_70616", "id": "reaction_10315543", "reactome": "R-XTR-199216", "name": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194" ], "products": [ "species_29374" ], "modifiers": [ [ "species_10315540", "catalyst" ] ], "additional_components": [ "ENSXETG00000030903" ] }, "reaction_10327160": { "compartment": "compartment_70101", "id": "reaction_10327160", "reactome": "R-XTR-2993802", "name": "HLCS biotinylates PC:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_199207", "species_10327148" ], "products": [ "species_111294", "species_10327153", "species_76577" ], "modifiers": [ [ "species_10327157", "catalyst" ] ], "additional_components": [ "A0A6I8QW74", "ENSXETG00000008415", "CHEBI:29035", "A0A6I8QW74", "ENSXETG00000008415", "CHEBI:29035", "ENSXETG00000013028" ] }, "reaction_10327703": { "compartment": "compartment_70101", "id": "reaction_10327703", "reactome": "R-XTR-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327153" ], "products": [ "species_10327240" ], "modifiers": [], "additional_components": [ "A0A6I8QW74", "ENSXETG00000008415", "CHEBI:29035", "CHEBI:29035", "A0A6I8QW74", "ENSXETG00000008415" ] }, "reaction_10331341": { "compartment": "compartment_70616", "id": "reaction_10331341", "reactome": "R-XTR-5694137", "name": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_5693984", "species_113521" ], "products": [ "species_200671", "species_379732" ], "modifiers": [ [ "species_10331338", "catalyst" ] ], "additional_components": [ "A0A6I8RGC7", "ENSXETG00000017162" ] }, "reaction_10315636": { "compartment": "compartment_70101", "id": "reaction_10315636", "reactome": "R-XTR-200735", "name": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_197969" ], "products": [ "species_29424", "species_200739" ], "modifiers": [ [ "species_10311706", "catalyst" ] ], "additional_components": [ "A0A6I8QRM0", "ENSXETG00000005754" ] }, "reaction_10334535": { "compartment": "compartment_70101", "id": "reaction_10334535", "reactome": "R-XTR-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111353", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_197969" ], "modifiers": [ [ "species_10334532", "catalyst" ] ], "additional_components": [ "Q63ZT8", "ENSXETT00000084678" ] }, "reaction_10315634": { "compartment": "compartment_70101", "id": "reaction_10315634", "reactome": "R-XTR-200651", "name": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_200739" ], "products": [ "species_200736", "species_197969" ], "modifiers": [ [ "species_10311706", "catalyst" ] ], "additional_components": [ "A0A6I8QRM0", "ENSXETG00000005754" ] }, "reaction_10320707": { "compartment": "compartment_70101", "id": "reaction_10320707", "reactome": "R-XTR-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947539", "species_111707" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10320704", "catalyst" ] ], "additional_components": [ "ENSXETG00000038002" ] }, "reaction_10327276": { "compartment": "compartment_70101", "id": "reaction_10327276", "reactome": "R-XTR-3149494", "name": "MMACHC:cob(II)alamin binds MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327268", "species_10327246" ], "products": [ "species_10327270" ], "modifiers": [], "additional_components": [ "ENSXETG00000004524", "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "A0A6I8Q401", "ENSXETG00000004524" ] }, "reaction_10327279": { "compartment": "compartment_70101", "id": "reaction_10327279", "reactome": "R-XTR-3149519", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10327244", "species_3149505" ], "products": [ "species_29366", "species_10327246", "species_1130611" ], "modifiers": [ [ "species_10327244", "catalyst" ] ], "additional_components": [ "ENSXETG00000003502", "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "ENSXETG00000003502" ] }, "reaction_10327274": { "compartment": "compartment_70101", "id": "reaction_10327274", "reactome": "R-XTR-3149492", "name": "cob(II)alamin dissociates from MMACHC:MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327270" ], "products": [ "species_3149479", "species_10327272" ], "modifiers": [], "additional_components": [ "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "A0A6I8Q401", "ENSXETG00000004524", "A0A6I8Q1G4", "ENSXETG00000003502", "A0A6I8Q401", "ENSXETG00000004524" ] }, "reaction_10327290": { "compartment": "compartment_5460", "id": "reaction_10327290", "reactome": "R-XTR-3159253", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159260", "species_113593" ], "products": [ "species_3159274", "species_3159297" ], "modifiers": [ [ "species_10327287", "catalyst" ] ], "additional_components": [ "A0A6I8T0P0", "ENSXETG00000040875" ] }, "reaction_10327249": { "compartment": "compartment_70101", "id": "reaction_10327249", "reactome": "R-XTR-3095889", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000241", "species_70106", "species_29364", "species_10327244" ], "products": [ "species_29366", "species_10327246" ], "modifiers": [ [ "species_10327244", "catalyst" ] ], "additional_components": [ "ENSXETG00000003502", "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "ENSXETG00000003502" ] }, "reaction_10327281": { "compartment": "compartment_70101", "id": "reaction_10327281", "reactome": "R-XTR-3149563", "name": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327270" ], "products": [ "species_3149564", "species_10327272" ], "modifiers": [], "additional_components": [ "A0A6I8Q1G4", "ENSXETG00000003502", "species_3149564", "A0A6I8Q401", "ENSXETG00000004524", "A0A6I8Q1G4", "ENSXETG00000003502", "A0A6I8Q401", "ENSXETG00000004524" ] }, "reaction_10327186": { "compartment": "compartment_70101", "id": "reaction_10327186", "reactome": "R-XTR-3000238", "name": "LMBRD1 transports lysosomal Cbl to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000239" ], "products": [ "species_3000241" ], "modifiers": [ [ "species_10327183", "catalyst" ] ], "additional_components": [ "ENSXETT00000025716" ] }, "reaction_10327301": { "compartment": "compartment_70101", "id": "reaction_10327301", "reactome": "R-XTR-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965131" ], "products": [ "species_3204324", "species_29408" ], "modifiers": [ [ "species_10327298", "catalyst" ] ], "additional_components": [ "A0A6I8RQ40", "ENSXETG00000039500", "CHEBI:33722", "CHEBI:44074", "species_113596" ] }, "reaction_10314427": { "compartment": "compartment_70101", "id": "reaction_10314427", "reactome": "R-XTR-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497805", "species_10314424" ], "products": [ "species_10314422", "species_198816" ], "modifiers": [ [ "species_10314424", "catalyst" ] ], "additional_components": [ "F6WBG7", "ENSXETT00000038708", "species_189444", "species_917955", "F6WBG7", "ENSXETT00000038708", "F6WBG7", "ENSXETT00000038708", "species_189444" ] }, "reaction_10314434": { "compartment": "compartment_876", "id": "reaction_10314434", "reactome": "R-XTR-198870", "name": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198836", "species_74113" ], "products": [ "species_83910", "species_198816" ], "modifiers": [ [ "species_10314431", "catalyst" ] ], "additional_components": [ "ENSXETT00000099885" ] }, "reaction_10326701": { "compartment": "compartment_70101", "id": "reaction_10326701", "reactome": "R-XTR-2395764", "name": "atREs binds to nascent CM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326405", "species_2534423" ], "products": [ "species_10326407" ], "modifiers": [], "additional_components": [ "species_171126", "species_171142", "A0A6I8RKY6", "ENSXETG00000026768", "A0A6I8PU04", "ENSXETG00000033423", "species_216762", "species_163579", "A0A6I8SNZ3", "ENSXETG00000038088", "Q08BT8", "ENSXETT00000008146", "species_2534407", "CHEBI:70762", "CHEBI:70760", "CHEBI:70761", "species_2534407", "CHEBI:70762", "CHEBI:70760", "CHEBI:70761", "species_171126", "species_171142", "A0A6I8RKY6", "ENSXETG00000026768", "A0A6I8PU04", "ENSXETG00000033423", "species_216762", "species_163579", "A0A6I8SNZ3", "ENSXETG00000038088", "Q08BT8", "ENSXETT00000008146" ] }, "reaction_10326780": { "compartment": "compartment_984", "id": "reaction_10326780", "reactome": "R-XTR-2404135", "name": "RBP4 binds atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395761", "species_10326766" ], "products": [ "species_10326768" ], "modifiers": [], "additional_components": [ "ENSXETT00000008077", "F6UH11", "ENSXETT00000008077", "species_30209" ] }, "reaction_10326411": { "compartment": "compartment_70101", "id": "reaction_10326411", "reactome": "R-XTR-2187332", "name": "Cytosolic CMs translocate to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326407" ], "products": [ "species_10326409" ], "modifiers": [], "additional_components": [ "species_2534407", "CHEBI:70762", "CHEBI:70760", "CHEBI:70761", "species_171126", "species_171142", "A0A6I8RKY6", "ENSXETG00000026768", "A0A6I8PU04", "ENSXETG00000033423", "species_216762", "species_163579", "A0A6I8SNZ3", "ENSXETG00000038088", "Q08BT8", "ENSXETT00000008146", "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "CHEBI:70760", "species_2534407", "CHEBI:70762", "CHEBI:70761", "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "A0A6I8SNZ3", "ENSXETG00000038088", "Q08BT8", "ENSXETT00000008146", "species_216762" ] }, "reaction_10320762": { "compartment": "compartment_984", "id": "reaction_10320762", "reactome": "R-XTR-975593", "name": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_975591" ], "products": [ "species_975590", "species_426576" ], "modifiers": [ [ "species_10314239", "catalyst" ] ], "additional_components": [ "F6ZWX1", "ENSXETT00000007508" ] }, "reaction_10326778": { "compartment": "compartment_984", "id": "reaction_10326778", "reactome": "R-XTR-2404134", "name": "RBP4:atROL binds TTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326768", "species_10326774" ], "products": [ "species_10326776" ], "modifiers": [], "additional_components": [ "F6UH11", "ENSXETT00000008077", "species_30209", "A4QNN7", "ENSXETT00000010246", "A4QNN7", "ENSXETT00000010246", "F6UH11", "ENSXETT00000008077", "species_30209" ] }, "reaction_10334456": { "compartment": "compartment_17957", "id": "reaction_10334456", "reactome": "R-XTR-6806674", "name": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806891", "species_6806657" ], "products": [ "species_6806362", "species_6806656" ], "modifiers": [ [ "species_10334453", "catalyst" ] ], "additional_components": [ "ENSXETG00000017414" ] }, "reaction_10323409": { "compartment": "compartment_70101", "id": "reaction_10323409", "reactome": "R-XTR-1497869", "name": "Salvage - Sepiapterin is reduced to BH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1497811", "species_29364" ], "products": [ "species_1497857", "species_29366" ], "modifiers": [ [ "species_10323229", "catalyst" ] ], "additional_components": [ "A0A6I8PWL6", "ENSXETG00000033127" ] }, "reaction_10323232": { "compartment": "compartment_70101", "id": "reaction_10323232", "reactome": "R-XTR-1475414", "name": "PTHP is reduced to BH4 by sepiapterin reductase (SPR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474179", "species_29364" ], "products": [ "species_29870", "species_29366" ], "modifiers": [ [ "species_10323229", "catalyst" ] ], "additional_components": [ "A0A6I8PWL6", "ENSXETG00000033127" ] }, "reaction_10323123": { "compartment": "compartment_70101", "id": "reaction_10323123", "reactome": "R-XTR-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10323120", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8S775", "ENSXETG00000034891" ] }, "reaction_10327167": { "compartment": "compartment_5460", "id": "reaction_10327167", "reactome": "R-XTR-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189444", "species_2162257", "species_113521" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10327164", "catalyst" ] ], "additional_components": [ "ENSXETG00000033101" ] }, "reaction_10314072": { "compartment": "compartment_70101", "id": "reaction_10314072", "reactome": "R-XTR-189425", "name": "UROD decarboxylates URO3 to COPRO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189407" ], "products": [ "species_189455", "species_113528" ], "modifiers": [ [ "species_10314069", "catalyst" ] ], "additional_components": [ "A0A6I8QYD9", "ENSXETG00000041183" ] }, "reaction_10314085": { "compartment": "compartment_70101", "id": "reaction_10314085", "reactome": "R-XTR-190141", "name": "ALAD binds to Pb2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190173", "species_10314078" ], "products": [ "species_10314083", "species_29426" ], "modifiers": [], "additional_components": [ "F7BED4", "ENSXETT00000050679", "species_29426", "F7BED4", "ENSXETT00000050679", "species_29426", "species_190173" ] }, "reaction_10314087": { "compartment": "compartment_70101", "id": "reaction_10314087", "reactome": "R-XTR-190182", "name": "UROD decarboxylates URO1 to COPRO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190157" ], "products": [ "species_113528", "species_190128" ], "modifiers": [ [ "species_10314069", "catalyst" ] ], "additional_components": [ "A0A6I8QYD9", "ENSXETG00000041183" ] }, "reaction_10314081": { "compartment": "compartment_70101", "id": "reaction_10314081", "reactome": "R-XTR-189439", "name": "ALAD condenses 2 dALAs to form PBG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189489" ], "products": [ "species_29356", "species_70106", "species_189464" ], "modifiers": [ [ "species_10314078", "catalyst" ] ], "additional_components": [ "F7BED4", "ENSXETT00000050679", "species_29426" ] }, "reaction_10338037": { "compartment": "compartment_70101", "id": "reaction_10338037", "reactome": "R-XTR-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338035" ], "products": [ "species_189386", "species_10313560" ], "modifiers": [], "additional_components": [ "A0A6I8S817", "ENSXETG00000036388", "species_189386", "ENSXETG00000036388" ] }, "reaction_10338039": { "compartment": "compartment_70101", "id": "reaction_10338039", "reactome": "R-XTR-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10313560" ], "products": [ "species_10338035" ], "modifiers": [], "additional_components": [ "ENSXETG00000036388", "A0A6I8S817", "ENSXETG00000036388", "species_189386" ] }, "reaction_10311500": { "compartment": "compartment_70101", "id": "reaction_10311500", "reactome": "R-XTR-70581", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_76213" ], "products": [ "species_29406", "species_29448" ], "modifiers": [ [ "species_10311497", "catalyst" ] ], "additional_components": [ "F6VWW1", "ENSXETT00000039920" ] }, "reaction_10332346": { "compartment": "compartment_70101", "id": "reaction_10332346", "reactome": "R-XTR-6787757", "name": "PXLP-K333-GADL1 decarboxylates acidic AAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787759" ], "products": [ "species_113528", "species_6787762" ], "modifiers": [ [ "species_10332343", "catalyst" ] ], "additional_components": [ "species_6787748", "species_29448", "CHEBI:17285", "species_73590", "species_1655445", "CHEBI:15891", "Q28D99", "ENSXETG00000014481" ] }, "reaction_10311511": { "compartment": "compartment_70101", "id": "reaction_10311511", "reactome": "R-XTR-70592", "name": "PXLP-K259-GOT1 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29448" ], "products": [ "species_29404", "species_76213" ], "modifiers": [ [ "species_10311497", "catalyst" ] ], "additional_components": [ "F6VWW1", "ENSXETT00000039920" ] }, "reaction_10331184": { "compartment": "compartment_70101", "id": "reaction_10331184", "reactome": "R-XTR-5691507", "name": "ASPA deacetylates NAA to acetate and L-aspartate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5691492" ], "products": [ "species_29416", "species_29448" ], "modifiers": [ [ "species_10331181", "catalyst" ] ], "additional_components": [ "species_29426", "Q28C61", "ENSXETG00000005789" ] }, "reaction_10336962": { "compartment": "compartment_5460", "id": "reaction_10336962", "reactome": "R-XTR-8954468", "name": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113553" ], "products": [ "species_29374", "species_8954466", "species_113529" ], "modifiers": [ [ "species_10336959", "catalyst" ] ], "additional_components": [ "ENSXETG00000002389" ] }, "reaction_10311532": { "compartment": "compartment_5460", "id": "reaction_10311532", "reactome": "R-XTR-70654", "name": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113585" ], "products": [ "species_31339", "species_113552" ], "modifiers": [ [ "species_10311529", "catalyst" ] ], "additional_components": [ "A0A6I8STU4", "ENSXETG00000040155" ] }, "reaction_10311513": { "compartment": "compartment_5460", "id": "reaction_10311513", "reactome": "R-XTR-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113521", "species_517495" ], "products": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "modifiers": [ [ "species_10311506", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29360", "species_113563", "species_113600", "species_73473", "Q5XGI4", "ENSXETT00000103326" ] }, "reaction_10332232": { "compartment": "compartment_5460", "id": "reaction_10332232", "reactome": "R-XTR-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10332229", "catalyst" ] ], "additional_components": [ "F7ALX3", "ENSXETT00000021260" ] }, "reaction_10311541": { "compartment": "compartment_5460", "id": "reaction_10311541", "reactome": "R-XTR-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10311538", "catalyst" ] ], "additional_components": [ "F7ALX3", "ENSXETT00000021260" ] }, "reaction_10311509": { "compartment": "compartment_5460", "id": "reaction_10311509", "reactome": "R-XTR-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "products": [ "species_113552", "species_113521", "species_517495" ], "modifiers": [ [ "species_10311506", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_113600", "species_73473", "species_29360", "species_113563", "Q5XGI4", "ENSXETT00000103326" ] }, "reaction_10336771": { "compartment": "compartment_70101", "id": "reaction_10336771", "reactome": "R-XTR-8942575", "name": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113592", "species_5691492" ], "products": [ "species_29370", "species_5693762" ], "modifiers": [ [ "species_10336766", "catalyst" ] ], "additional_components": [ "ENSXETG00000030755" ] }, "reaction_10311674": { "compartment": "compartment_70101", "id": "reaction_10311674", "reactome": "R-XTR-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_31365" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10311671", "catalyst" ] ], "additional_components": [ "species_198836", "species_435347", "F7AAG5", "ENSXETT00000008159" ] }, "reaction_10326051": { "compartment": "compartment_984", "id": "reaction_10326051", "reactome": "R-XTR-2160492", "name": "IL4I1:FAD oxidises L-Phe to kPPV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_351993", "species_352327" ], "products": [ "species_2022135", "species_351629", "species_2160466" ], "modifiers": [ [ "species_10326048", "catalyst" ] ], "additional_components": [ "A0A5S6N697", "ENSXETG00000031027", "species_113596" ] }, "reaction_10332252": { "compartment": "compartment_5460", "id": "reaction_10332252", "reactome": "R-XTR-6784423", "name": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784229" ], "products": [ "species_904849", "species_113557" ], "modifiers": [ [ "species_10332249", "catalyst" ] ], "additional_components": [ "Q5M8W9", "ENSXETT00000007453" ] }, "reaction_10332243": { "compartment": "compartment_5460", "id": "reaction_10332243", "reactome": "R-XTR-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10332240", "catalyst" ] ], "additional_components": [ "A0A6I8SGS7", "ENSXETG00000040955", "species_113596" ] }, "reaction_10334594": { "compartment": "compartment_17951", "id": "reaction_10334594", "reactome": "R-XTR-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_6810061" ], "products": [ "species_113575", "species_389843", "species_6810070" ], "modifiers": [ [ "species_10334591", "catalyst" ] ], "additional_components": [ "F6TSP3", "ENSXETT00000046108", "species_113596" ] }, "reaction_10311490": { "compartment": "compartment_5460", "id": "reaction_10311490", "reactome": "R-XTR-70555", "name": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113561", "species_29896" ], "products": [ "species_113548", "species_113581", "species_29676" ], "modifiers": [ [ "species_10311487", "catalyst" ], [ "species_30471", "catalyst" ] ], "additional_components": [ "ENSXETG00000006919" ] }, "reaction_10311481": { "compartment": "compartment_70101", "id": "reaction_10311481", "reactome": "R-XTR-70523", "name": "PXLP-K314-GPT transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29432" ], "products": [ "species_29404", "species_29398" ], "modifiers": [ [ "species_10311478", "catalyst" ] ], "additional_components": [ "Q28DB5", "ENSXETG00000007140" ] }, "reaction_10323908": { "compartment": "compartment_70101", "id": "reaction_10323908", "reactome": "R-XTR-1614654", "name": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352015", "species_174369" ], "products": [ "species_174390", "species_1614585" ], "modifiers": [ [ "species_10323905", "catalyst" ] ], "additional_components": [ "Q5M8Z0", "ENSXETT00000001133", "species_29426" ] }, "reaction_10331943": { "compartment": "compartment_70101", "id": "reaction_10331943", "reactome": "R-XTR-5696838", "name": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4789070", "species_174369" ], "products": [ "species_70106", "species_174390" ], "modifiers": [ [ "species_10331940", "catalyst" ] ], "additional_components": [ "species_29426", "Q5M8Z0", "ENSXETT00000001133" ] }, "reaction_10322223": { "compartment": "compartment_70101", "id": "reaction_10322223", "reactome": "R-XTR-1237096", "name": "Methylthio-ribose-P = Methylthio-ribulose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237165" ], "products": [ "species_1237107" ], "modifiers": [ [ "species_10322220", "catalyst" ] ], "additional_components": [ "ENSXETT00000047323" ] }, "reaction_10322232": { "compartment": "compartment_70101", "id": "reaction_10322232", "reactome": "R-XTR-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_1237155" ], "products": [ "species_29460", "species_1237122" ], "modifiers": [ [ "species_10322229", "catalyst" ] ], "additional_components": [ "species_435347", "Q6DIY2", "ENSXETT00000000659" ] }, "reaction_10322241": { "compartment": "compartment_70101", "id": "reaction_10322241", "reactome": "R-XTR-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1237176" ], "products": [ "species_29372", "species_70106", "species_1237155" ], "modifiers": [ [ "species_10322238", "catalyst" ] ], "additional_components": [ "Q28C69", "ENSXETG00000012582", "species_109496" ] }, "reaction_10334661": { "compartment": "compartment_70101", "id": "reaction_10334661", "reactome": "R-XTR-6814165", "name": "PXLP-K333-GADL1 decarboxylates CSA to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787748" ], "products": [ "species_1655445", "species_113528" ], "modifiers": [ [ "species_10332343", "catalyst" ] ], "additional_components": [ "Q28D99", "ENSXETG00000014481" ] }, "reaction_10311608": { "compartment": "compartment_70101", "id": "reaction_10311608", "reactome": "R-XTR-70906", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_34979" ], "products": [ "species_30158", "species_70106" ], "modifiers": [ [ "species_10311605", "catalyst" ] ], "additional_components": [ "ENSXETT00000046755" ] }, "reaction_10332309": { "compartment": "compartment_70101", "id": "reaction_10332309", "reactome": "R-XTR-6786245", "name": "CARNS1 transforms ATP, L-His, b-Ala to CARN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612", "species_113592", "species_73590" ], "products": [ "species_6786250", "species_29372", "species_29370" ], "modifiers": [ [ "species_10332306", "catalyst" ] ], "additional_components": [ "ENSXETG00000034643" ] }, "reaction_10311601": { "compartment": "compartment_70101", "id": "reaction_10311601", "reactome": "R-XTR-70903", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30721" ], "products": [ "species_34979" ], "modifiers": [ [ "species_10311598", "catalyst" ] ], "additional_components": [ "species_29360", "A0A6I8R5U8", "ENSXETG00000011543" ] }, "reaction_10336008": { "compartment": "compartment_5668575", "id": "reaction_10336008", "reactome": "R-XTR-8878581", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662670", "species_5668566" ], "products": [ "species_8878586", "species_5668574" ], "modifiers": [ [ "species_10336005", "catalyst" ] ], "additional_components": [ "ENSXETG00000012905" ] }, "reaction_10311617": { "compartment": "compartment_5460", "id": "reaction_10311617", "reactome": "R-XTR-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113556", "species_113521" ], "products": [ "species_113529", "species_508531", "species_29362" ], "modifiers": [ [ "species_10311614", "catalyst" ] ], "additional_components": [ "F7BQF6", "ENSXETT00000011316" ] }, "reaction_10336981": { "compartment": "compartment_5460", "id": "reaction_10336981", "reactome": "R-XTR-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_6784215" ], "products": [ "species_113590", "species_164934", "species_113521" ], "modifiers": [ [ "species_10332236", "catalyst" ] ], "additional_components": [ "ENSXETG00000040955" ] }, "reaction_10316697": { "compartment": "compartment_70101", "id": "reaction_10316697", "reactome": "R-XTR-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10316694", "catalyst" ] ], "additional_components": [ "ENSXETG00000039007" ] }, "reaction_10316699": { "compartment": "compartment_70101", "id": "reaction_10316699", "reactome": "R-XTR-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_353555", "species_76194" ], "modifiers": [ [ "species_10316694", "catalyst" ] ], "additional_components": [ "ENSXETG00000039007" ] }, "reaction_10316690": { "compartment": "compartment_70101", "id": "reaction_10316690", "reactome": "R-XTR-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10316687", "catalyst" ] ], "additional_components": [ "ENSXETG00000040919" ] }, "reaction_10311558": { "compartment": "compartment_70101", "id": "reaction_10311558", "reactome": "R-XTR-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10311555", "catalyst" ] ], "additional_components": [ "A0A6I8QKY2", "ENSXETG00000040919", "F6VJF3", "ENSXETT00000007603" ] }, "reaction_10311567": { "compartment": "compartment_5460", "id": "reaction_10311567", "reactome": "R-XTR-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10311564", "catalyst" ] ], "additional_components": [ "F7DXL6", "ENSXETT00000001790" ] }, "reaction_10311576": { "compartment": "compartment_5460", "id": "reaction_10311576", "reactome": "R-XTR-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70718", "species_113596" ], "products": [ "species_70799", "species_31649" ], "modifiers": [ [ "species_10311573", "catalyst" ] ], "additional_components": [ "species_113596", "F6VHN6", "ENSXETT00000035066" ] }, "reaction_10311592": { "compartment": "compartment_5460", "id": "reaction_10311592", "reactome": "R-XTR-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10311589", "catalyst" ] ], "additional_components": [ "ENSXETT00000033364" ] }, "reaction_10311585": { "compartment": "compartment_5460", "id": "reaction_10311585", "reactome": "R-XTR-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10311582", "catalyst" ] ], "additional_components": [ "Q5BKN8", "ENSXETT00000031684" ] }, "reaction_10311725": { "compartment": "compartment_70101", "id": "reaction_10311725", "reactome": "R-XTR-71286", "name": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_30401" ], "products": [ "species_29916", "species_70106", "species_71285" ], "modifiers": [ [ "species_10311722", "catalyst" ] ], "additional_components": [ "ENSXETG00000003703" ] }, "reaction_10311718": { "compartment": "compartment_17927", "id": "reaction_10311718", "reactome": "R-XTR-71275", "name": "arginine + glycine => ornithine + guanidoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113530", "species_113545" ], "products": [ "species_113543", "species_113586" ], "modifiers": [ [ "species_10311715", "catalyst" ] ], "additional_components": [ "Q6P832", "ENSXETT00000035125" ] }, "reaction_10332468": { "compartment": "compartment_5460", "id": "reaction_10332468", "reactome": "R-XTR-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_6798194", "species_113521" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10311612", "catalyst" ] ], "additional_components": [ "ENSXETT00000011316" ] }, "reaction_10311690": { "compartment": "compartment_70101", "id": "reaction_10311690", "reactome": "R-XTR-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_29970" ], "products": [ "species_34351", "species_29356", "species_29366" ], "modifiers": [ [ "species_10311687", "catalyst" ] ], "additional_components": [ "ENSXETT00000035436" ] }, "reaction_10311683": { "compartment": "compartment_70101", "id": "reaction_10311683", "reactome": "R-XTR-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29500", "species_29368" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10311680", "catalyst" ] ], "additional_components": [ "species_189444", "Q5EBG2", "ENSXETT00000048482" ] }, "reaction_10311699": { "compartment": "compartment_70101", "id": "reaction_10311699", "reactome": "R-XTR-71218", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30487" ], "products": [ "species_36027" ], "modifiers": [ [ "species_10311696", "catalyst" ] ], "additional_components": [ "Q6DIZ0", "ENSXETG00000015771", "species_435347" ] }, "reaction_10326790": { "compartment": "compartment_70101", "id": "reaction_10326790", "reactome": "R-XTR-2408524", "name": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5359016", "species_5357697" ], "products": [ "species_5357660", "species_29432", "species_5359011" ], "modifiers": [ [ "species_10326787", "catalyst" ] ], "additional_components": [ "Q5U4Q9", "ENSXETT00000026454" ] }, "reaction_10311709": { "compartment": "compartment_70101", "id": "reaction_10311709", "reactome": "R-XTR-71249", "name": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31503" ], "products": [ "species_31311", "species_29424" ], "modifiers": [ [ "species_10311706", "catalyst" ] ], "additional_components": [ "A0A6I8QRM0", "ENSXETG00000005754" ] }, "reaction_10311917": { "compartment": "compartment_70101", "id": "reaction_10311917", "reactome": "R-XTR-73632", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_83928" ], "products": [ "species_29370", "species_109366" ], "modifiers": [ [ "species_10311914", "catalyst" ] ], "additional_components": [ "A0A6I8SMB6", "ENSXETG00000001323" ] }, "reaction_10312345": { "compartment": "compartment_70101", "id": "reaction_10312345", "reactome": "R-XTR-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10312342", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_727810", "species_109402", "B1H116", "ENSXETT00000037794" ] }, "reaction_10311908": { "compartment": "compartment_70101", "id": "reaction_10311908", "reactome": "R-XTR-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500829" ], "products": [ "species_500430", "species_31633" ], "modifiers": [ [ "species_10311905", "catalyst" ] ], "additional_components": [ "CHEBI:15698", "CHEBI:17562", "CHEBI:16450", "CHEBI:16704", "species_29426", "A0A6I8SN57", "ENSXETG00000037611" ] }, "reaction_10311993": { "compartment": "compartment_70101", "id": "reaction_10311993", "reactome": "R-XTR-74241", "name": "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500173" ], "products": [ "species_500172", "species_31633" ], "modifiers": [ [ "species_10311990", "catalyst" ] ], "additional_components": [ "species_8857850", "CHEBI:17256", "CHEBI:28997", "species_83927", "ENSXETG00000003459" ] }, "reaction_10312600": { "compartment": "compartment_70101", "id": "reaction_10312600", "reactome": "R-XTR-112033", "name": "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_500244" ], "products": [ "species_29372", "species_500172" ], "modifiers": [ [ "species_10311999", "catalyst" ] ], "additional_components": [ "CHEBI:28542", "CHEBI:35425", "CHEBI:28997", "species_83927", "A0A6I8SRS9", "ENSXETG00000016932" ] }, "reaction_10312602": { "compartment": "compartment_70101", "id": "reaction_10312602", "reactome": "R-XTR-112034", "name": "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83956", "species_500244" ], "products": [ "species_29372", "species_500245" ], "modifiers": [ [ "species_10311999", "catalyst" ] ], "additional_components": [ "CHEBI:28542", "CHEBI:35425", "CHEBI:17172", "CHEBI:16750", "A0A6I8SRS9", "ENSXETG00000016932" ] }, "reaction_10312245": { "compartment": "compartment_70101", "id": "reaction_10312245", "reactome": "R-XTR-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76577" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10312242", "catalyst" ] ], "additional_components": [ "A0A6I8SRY8", "ENSXETG00000002009" ] }, "reaction_10311986": { "compartment": "compartment_70101", "id": "reaction_10311986", "reactome": "R-XTR-74215", "name": "guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_500259" ], "products": [ "species_111294", "species_500260" ], "modifiers": [ [ "species_10311983", "catalyst" ] ], "additional_components": [ "species_83956", "species_113599", "species_29602", "species_5696194", "A0A6I8SQB1", "ENSXETG00000019768", "species_109496" ] }, "reaction_10312364": { "compartment": "compartment_70101", "id": "reaction_10312364", "reactome": "R-XTR-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_6788778", "species_113592" ], "modifiers": [ [ "species_10312361", "catalyst" ] ], "additional_components": [ "species_29370", "CHEBI:28846", "CHEBI:16174", "CHEBI:17239", "species_159448", "species_727810", "CHEBI:15918", "CHEBI:17713", "Q6P618", "ENSXETG00000006260", "A0A6I8Q090", "ENSXETG00000033226" ] }, "reaction_10312076": { "compartment": "compartment_70101", "id": "reaction_10312076", "reactome": "R-XTR-75125", "name": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_500006" ], "products": [ "species_500009", "species_113592" ], "modifiers": [ [ "species_10311896", "catalyst" ] ], "additional_components": [ "species_417888", "CHEBI:28846", "CHEBI:17239", "species_727810", "CHEBI:15918", "species_109402", "ENSXETG00000036011" ] }, "reaction_10312366": { "compartment": "compartment_70101", "id": "reaction_10312366", "reactome": "R-XTR-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788778", "species_113592" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10312361", "catalyst" ] ], "additional_components": [ "species_159448", "species_727810", "CHEBI:15918", "CHEBI:17713", "species_29370", "CHEBI:28846", "CHEBI:16174", "CHEBI:17239", "Q6P618", "ENSXETG00000006260", "A0A6I8Q090", "ENSXETG00000033226" ] }, "reaction_10312373": { "compartment": "compartment_70101", "id": "reaction_10312373", "reactome": "R-XTR-110144", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_113592", "species_76577" ], "modifiers": [ [ "species_10312370", "catalyst" ] ], "additional_components": [ "ENSXETT00000057918" ] }, "reaction_10312550": { "compartment": "compartment_70101", "id": "reaction_10312550", "reactome": "R-XTR-111746", "name": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312547", "species_29450" ], "products": [ "species_10312544", "species_111745" ], "modifiers": [ [ "species_10312547", "catalyst" ] ], "additional_components": [ "ENSXETG00000026267", "ENSXETG00000026267", "ENSXETG00000026267" ] }, "reaction_10311926": { "compartment": "compartment_7660", "id": "reaction_10311926", "reactome": "R-XTR-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742" ], "modifiers": [ [ "species_10311923", "catalyst" ] ], "additional_components": [ "A0A6I8RWX6", "ENSXETG00000036738" ] }, "reaction_10326748": { "compartment": "compartment_70101", "id": "reaction_10326748", "reactome": "R-XTR-2395879", "name": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395883", "species_29356" ], "products": [ "species_2395817", "species_29372" ], "modifiers": [ [ "species_10326740", "catalyst" ] ], "additional_components": [ "ENSXETG00000037630" ] }, "reaction_10326751": { "compartment": "compartment_70101", "id": "reaction_10326751", "reactome": "R-XTR-2395965", "name": "NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395963", "species_29356" ], "products": [ "species_29372", "species_2395964" ], "modifiers": [ [ "species_10326740", "catalyst" ] ], "additional_components": [ "ENSXETG00000037630" ] }, "reaction_10326734": { "compartment": "compartment_70101", "id": "reaction_10326734", "reactome": "R-XTR-2395869", "name": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395852" ], "products": [ "species_111294", "species_2395817" ], "modifiers": [ [ "species_10326731", "catalyst" ] ], "additional_components": [ "ENSXETG00000039868" ] }, "reaction_10326746": { "compartment": "compartment_70101", "id": "reaction_10326746", "reactome": "R-XTR-2395876", "name": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395883", "species_29356" ], "products": [ "species_2395817", "species_29372" ], "modifiers": [ [ "species_10326731", "catalyst" ] ], "additional_components": [ "ENSXETG00000039868" ] }, "reaction_10326724": { "compartment": "compartment_70101", "id": "reaction_10326724", "reactome": "R-XTR-2395818", "name": "NUDT1 hydrolyses 2-OH-dATP to 2-OH-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395822" ], "products": [ "species_111294", "species_2395855" ], "modifiers": [ [ "species_10326721", "catalyst" ] ], "additional_components": [ "species_109496", "Q6GL35", "ENSXETT00000085967" ] }, "reaction_10326727": { "compartment": "compartment_70101", "id": "reaction_10326727", "reactome": "R-XTR-2395849", "name": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395852" ], "products": [ "species_111294", "species_2395817" ], "modifiers": [ [ "species_10326721", "catalyst" ] ], "additional_components": [ "species_109496", "Q6GL35", "ENSXETT00000085967" ] }, "reaction_10326743": { "compartment": "compartment_70101", "id": "reaction_10326743", "reactome": "R-XTR-2395873", "name": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395880" ], "products": [ "species_29372", "species_2395877" ], "modifiers": [ [ "species_10326740", "catalyst" ] ], "additional_components": [ "ENSXETG00000037630" ] }, "reaction_10331430": { "compartment": "compartment_70101", "id": "reaction_10331430", "reactome": "R-XTR-5696049", "name": "ADPRM hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1131972" ], "products": [ "species_73578", "species_76577" ], "modifiers": [ [ "species_10331427", "catalyst" ] ], "additional_components": [ "CHEBI:29035", "Q66JJ3", "ENSXETT00000024142" ] }, "reaction_10326736": { "compartment": "compartment_70101", "id": "reaction_10326736", "reactome": "R-XTR-2395872", "name": "NUDT1 hydrolyses 2-OH-ATP to 2-OH-AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395868" ], "products": [ "species_111294", "species_2395878" ], "modifiers": [ [ "species_10326721", "catalyst" ] ], "additional_components": [ "species_109496", "Q6GL35", "ENSXETT00000085967" ] }, "reaction_10312296": { "compartment": "compartment_70101", "id": "reaction_10312296", "reactome": "R-XTR-109387", "name": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500125" ], "products": [ "species_29372", "species_500124" ], "modifiers": [ [ "species_10312291", "catalyst" ], [ "species_29370", "catalyst" ] ], "additional_components": [ "species_159448", "species_29602", "species_109330", "CHEBI:17713", "species_5696194", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_8857850", "CHEBI:17256", "species_83927", "CHEBI:16750", "species_109496", "A0A6I8QEC6", "ENSXETG00000037368" ] }, "reaction_10326856": { "compartment": "compartment_70101", "id": "reaction_10326856", "reactome": "R-XTR-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_111294", "species_109330" ], "modifiers": [ [ "species_10326847", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "A0A6I8SWT3", "ENSXETG00000036089" ] }, "reaction_10312011": { "compartment": "compartment_70101", "id": "reaction_10312011", "reactome": "R-XTR-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500120", "species_29356" ], "products": [ "species_29372", "species_500118" ], "modifiers": [ [ "species_10312008", "catalyst" ] ], "additional_components": [ "species_29602", "species_109330", "species_5696194", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_83927", "CHEBI:16750", "species_109496", "Q5EBF1", "ENSXETG00000009475" ] }, "reaction_10326853": { "compartment": "compartment_70101", "id": "reaction_10326853", "reactome": "R-XTR-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_111294", "species_111584" ], "modifiers": [ [ "species_10326847", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "A0A6I8SWT3", "ENSXETG00000036089" ] }, "reaction_10312305": { "compartment": "compartment_70101", "id": "reaction_10312305", "reactome": "R-XTR-109470", "name": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500120", "species_29356" ], "products": [ "species_29372", "species_500118" ], "modifiers": [ [ "species_10312302", "catalyst" ] ], "additional_components": [ "species_29602", "species_109330", "species_5696194", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_83927", "CHEBI:16750", "A0A6I8QJ17", "ENSXETG00000037325", "species_109496" ] }, "reaction_10326850": { "compartment": "compartment_70101", "id": "reaction_10326850", "reactome": "R-XTR-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_111294", "species_29602" ], "modifiers": [ [ "species_10326847", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "A0A6I8SWT3", "ENSXETG00000036089" ] }, "reaction_10312314": { "compartment": "compartment_5460", "id": "reaction_10312314", "reactome": "R-XTR-109514", "name": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500420", "species_113521" ], "products": [ "species_113548", "species_500421" ], "modifiers": [ [ "species_10312311", "catalyst" ] ], "additional_components": [ "species_109366", "species_500742", "CHEBI:28895", "species_109402", "CHEBI:28070", "species_83928", "CHEBI:16450", "CHEBI:16704", "A0A6I8QJ17", "ENSXETG00000037325", "species_109496" ] }, "reaction_10312294": { "compartment": "compartment_70101", "id": "reaction_10312294", "reactome": "R-XTR-109380", "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500347" ], "products": [ "species_500346", "species_29372" ], "modifiers": [ [ "species_10312291", "catalyst" ], [ "species_29370", "catalyst" ] ], "additional_components": [ "species_727810", "CHEBI:15918", "species_109366", "species_500742", "species_109402", "CHEBI:15698", "CHEBI:16450", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_109496", "A0A6I8QEC6", "ENSXETG00000037368" ] }, "reaction_10312307": { "compartment": "compartment_70101", "id": "reaction_10312307", "reactome": "R-XTR-109480", "name": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500414" ], "products": [ "species_29372", "species_500415" ], "modifiers": [ [ "species_10312302", "catalyst" ] ], "additional_components": [ "CHEBI:28070", "CHEBI:28895", "species_109366", "species_500742", "CHEBI:46322", "species_109402", "CHEBI:16450", "CHEBI:16704", "species_83928", "A0A6I8QJ17", "ENSXETG00000037325", "species_109496" ] }, "reaction_10334973": { "compartment": "compartment_984", "id": "reaction_10334973", "reactome": "R-XTR-8851356", "name": "NTPDase5 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8936165" ], "products": [ "species_8851369", "species_109277" ], "modifiers": [ [ "species_10334970", "catalyst" ] ], "additional_components": [ "species_29370", "species_417888", "species_29420", "CHEBI:17239", "species_109402", "species_727810", "species_5696194", "species_159448", "A0A6I8Q679", "ENSXETG00000030591", "species_109496", "species_74112" ] }, "reaction_10334998": { "compartment": "compartment_528865", "id": "reaction_10334998", "reactome": "R-XTR-8851494", "name": "NTPDase7 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851517", "species_8851509" ], "products": [ "species_8851513", "species_8851518" ], "modifiers": [ [ "species_10334995", "catalyst" ] ], "additional_components": [ "CHEBI:15713", "species_29438", "CHEBI:17677", "CHEBI:17239", "species_417888", "species_29420", "species_74112", "Q28CF8", "ENSXETG00000003746" ] }, "reaction_10334848": { "compartment": "compartment_984", "id": "reaction_10334848", "reactome": "R-XTR-8850846", "name": "NTPDase1 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8870907" ], "products": [ "species_8870906", "species_109277" ], "modifiers": [ [ "species_10334845", "catalyst" ] ], "additional_components": [ "A0A6I8QSY1", "ENSXETG00000037156", "species_109496", "species_74112" ] }, "reaction_10334960": { "compartment": "compartment_984", "id": "reaction_10334960", "reactome": "R-XTR-8851089", "name": "NTPDase2 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936166", "species_109276" ], "products": [ "species_109277", "species_8851092" ], "modifiers": [ [ "species_10334957", "catalyst" ] ], "additional_components": [ "species_2509836", "species_29438", "CHEBI:15713", "CHEBI:17677", "species_113593", "CHEBI:17808", "species_29370", "species_417888", "species_29420", "CHEBI:17239", "K9J7Q8", "ENSXETT00000008576", "species_109496", "species_74112" ] }, "reaction_10334851": { "compartment": "compartment_876", "id": "reaction_10334851", "reactome": "R-XTR-8850854", "name": "NTPDase1 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8870906" ], "products": [ "species_109277", "species_8870962" ], "modifiers": [ [ "species_10334845", "catalyst" ] ], "additional_components": [ "A0A6I8QSY1", "ENSXETG00000037156", "species_109496", "species_74112" ] }, "reaction_10311933": { "compartment": "compartment_70101", "id": "reaction_10311933", "reactome": "R-XTR-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_111584", "species_29472" ], "products": [ "species_111294", "species_29404", "species_113578", "species_76577" ], "modifiers": [ [ "species_10311930", "catalyst" ] ], "additional_components": [ "ENSXETG00000033049" ] }, "reaction_10312540": { "compartment": "compartment_70101", "id": "reaction_10312540", "reactome": "R-XTR-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29448", "species_29602" ], "products": [ "species_29372", "species_29420", "species_35141" ], "modifiers": [ [ "species_10312537", "catalyst" ], [ "species_30014", "inhibitor" ], [ "species_29420", "inhibitor" ], [ "species_35141", "inhibitor" ], [ "species_113578", "inhibitor" ] ], "additional_components": [ "Q6DIW6", "ENSXETG00000024695", "species_109496", "Q6P875", "ENSXETG00000014538" ] }, "reaction_10311946": { "compartment": "compartment_70101", "id": "reaction_10311946", "reactome": "R-XTR-73814", "name": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111292", "species_113592", "species_29424" ], "products": [ "species_29372", "species_111338", "species_29370" ], "modifiers": [ [ "species_10311937", "catalyst" ] ], "additional_components": [ "ENSXETG00000014148" ] }, "reaction_10311940": { "compartment": "compartment_70101", "id": "reaction_10311940", "reactome": "R-XTR-73810", "name": "FGAM + ATP => AIR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111369" ], "products": [ "species_29372", "species_111370", "species_29370" ], "modifiers": [ [ "species_10311937", "catalyst" ] ], "additional_components": [ "ENSXETG00000014148" ] }, "reaction_10311943": { "compartment": "compartment_70101", "id": "reaction_10311943", "reactome": "R-XTR-73813", "name": "GAR + 10-Formyl-THF => FGAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111338", "species_419151" ], "products": [ "species_111354", "species_111355" ], "modifiers": [ [ "species_10311937", "catalyst" ] ], "additional_components": [ "ENSXETG00000014148" ] }, "reaction_10332370": { "compartment": "compartment_70101", "id": "reaction_10332370", "reactome": "R-XTR-6788912", "name": "LHPP:Mg2+ dimer hydrolyses PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10332367", "catalyst" ] ], "additional_components": [ "A0A6I8PWJ2", "ENSXETG00000031230", "species_109496" ] }, "reaction_10315931": { "compartment": "compartment_70101", "id": "reaction_10315931", "reactome": "R-XTR-203553", "name": "eNOS binds NOSIP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315923", "species_10315927" ], "products": [ "species_10315929" ], "modifiers": [], "additional_components": [ "species_189444", "species_29426", "species_73524", "species_113596", "A0A6I8RYH7", "ENSXETG00000011979", "ENSXETT00000065273", "Q6P829", "ENSXETT00000065273", "species_189444", "species_29426", "species_73524", "species_113596", "A0A6I8RYH7", "ENSXETG00000011979" ] }, "reaction_10315952": { "compartment": "compartment_876", "id": "reaction_10315952", "reactome": "R-XTR-203680", "name": "eNOS:NOSIP translocation from caveolae to intracellular compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315929" ], "products": [ "species_10315950" ], "modifiers": [], "additional_components": [ "Q6P829", "ENSXETT00000065273", "species_189444", "species_29426", "species_73524", "species_113596", "A0A6I8RYH7", "ENSXETG00000011979", "Q6P829", "ENSXETT00000065273", "A0A6I8RYH7", "ENSXETG00000011979", "species_189444", "species_29426", "species_73524", "species_113596", "species_29870" ] }, "reaction_10315944": { "compartment": "compartment_70101", "id": "reaction_10315944", "reactome": "R-XTR-203611", "name": "N-myristoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_184174", "species_10315942" ], "products": [ "species_10315712" ], "modifiers": [], "additional_components": [ "ENSXETG00000011979", "ENSXETG00000011979" ] }, "reaction_10315720": { "compartment": "compartment_20699", "id": "reaction_10315720", "reactome": "R-XTR-202132", "name": "depalmitoylated eNOS translocates from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315714" ], "products": [ "species_10315718" ], "modifiers": [], "additional_components": [ "species_189444", "species_29426", "species_73524", "species_113596", "A0A6I8RYH7", "ENSXETG00000011979", "species_29870", "species_189444", "species_29426", "species_73524", "A0A6I8RYH7", "ENSXETG00000011979", "species_113596", "species_29870" ] }, "reaction_10315940": { "compartment": "compartment_20699", "id": "reaction_10315940", "reactome": "R-XTR-203567", "name": "palmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315712", "species_200993" ], "products": [ "species_10315933" ], "modifiers": [ [ "species_10315937", "catalyst" ] ], "additional_components": [ "ENSXETG00000011979", "ENSXETG00000011979", "ENSXETT00000055800" ] }, "reaction_10329588": { "compartment": "compartment_70101", "id": "reaction_10329588", "reactome": "R-XTR-5340226", "name": "CYGB dioxygenates NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_202124", "species_70106", "species_29364", "species_10329583" ], "products": [ "species_432031", "species_29366", "species_10329581" ], "modifiers": [ [ "species_10329583", "catalyst" ] ], "additional_components": [ "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_113533", "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_113533" ] }, "reaction_10329585": { "compartment": "compartment_70101", "id": "reaction_10329585", "reactome": "R-XTR-5340214", "name": "CYGB binds O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_10329581" ], "products": [ "species_10329583" ], "modifiers": [], "additional_components": [ "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_113533" ] }, "reaction_10315954": { "compartment": "compartment_20699", "id": "reaction_10315954", "reactome": "R-XTR-203700", "name": "eNOS translocation from Golgi to Caveolae", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315933" ], "products": [ "species_10315923" ], "modifiers": [], "additional_components": [ "ENSXETG00000011979", "species_189444", "species_29426", "species_73524", "species_113596", "A0A6I8RYH7", "ENSXETG00000011979" ] }, "reaction_10313418": { "compartment": "compartment_70616", "id": "reaction_10313418", "reactome": "R-XTR-170026", "name": "Protons are translocated from the intermembrane space to the matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163953" ], "products": [ "species_113529" ], "modifiers": [ [ "species_10313240", "catalyst" ], [ "species_30495", "catalyst" ], [ "species_170037", "inhibitor" ] ], "additional_components": [ "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_113593", "species_29370", "species_29420", "species_29438" ] }, "reaction_10313247": { "compartment": "compartment_70616", "id": "reaction_10313247", "reactome": "R-XTR-166214", "name": "FA anion flip-flops to the opposite surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313242" ], "products": [ "species_10313244" ], "modifiers": [ [ "species_10313242", "catalyst" ] ], "additional_components": [ "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_166216", "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_166216", "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_166216" ] }, "reaction_10313249": { "compartment": "compartment_70616", "id": "reaction_10313249", "reactome": "R-XTR-166220", "name": "FA anion diffuses laterally to UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_166213", "species_10313240" ], "products": [ "species_10313242" ], "modifiers": [], "additional_components": [ "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_166216" ] }, "reaction_10313251": { "compartment": "compartment_70616", "id": "reaction_10313251", "reactome": "R-XTR-166387", "name": "The FA anion diffuses away laterally from UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313244" ], "products": [ "species_166216", "species_10313240" ], "modifiers": [], "additional_components": [ "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740", "species_166216", "F7AQ05", "ENSXETT00000055772", "A9ULC3", "ENSXETT00000060557", "A0A6I8SUP0", "ENSXETG00000016256", "A0A6I8QNV8", "ENSXETG00000034740" ] }, "reaction_10338068": { "compartment": "compartment_984", "id": "reaction_10338068", "reactome": "R-XTR-9673054", "name": "PM20D1 hydrolyzes oleoyl-phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_9673044" ], "products": [ "species_351993", "species_9673048" ], "modifiers": [ [ "species_10338063", "catalyst" ] ], "additional_components": [ "ENSXETG00000005950" ] }, "reaction_10338066": { "compartment": "compartment_984", "id": "reaction_10338066", "reactome": "R-XTR-9673053", "name": "PM20D1 transforms oleoyl-phe from oleate and phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351993", "species_9673048" ], "products": [ "species_109276", "species_9673044" ], "modifiers": [ [ "species_10338063", "catalyst" ] ], "additional_components": [ "ENSXETG00000005950" ] }, "reaction_10320175": { "compartment": "compartment_5460", "id": "reaction_10320175", "reactome": "R-XTR-880002", "name": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_880046", "species_879997" ], "products": [ "species_113594", "species_880041" ], "modifiers": [ [ "species_10320172", "catalyst" ] ], "additional_components": [ "ENSXETG00000023251" ] }, "reaction_10332223": { "compartment": "compartment_70101", "id": "reaction_10332223", "reactome": "R-XTR-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29708", "species_29450" ], "modifiers": [ [ "species_10332220", "catalyst" ] ], "additional_components": [ "species_29426", "B4F6K2", "ENSXETG00000007202" ] }, "reaction_10337199": { "compartment": "compartment_5460", "id": "reaction_10337199", "reactome": "R-XTR-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_113557", "species_29376" ], "modifiers": [ [ "species_10337196", "catalyst" ] ], "additional_components": [ "A0A6I8PLR1", "ENSXETG00000033843", "species_109496" ] }, "reaction_10318622": { "compartment": "compartment_5460", "id": "reaction_10318622", "reactome": "R-XTR-450984", "name": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_29938" ], "products": [ "species_113594", "species_113529", "species_113600", "species_29376" ], "modifiers": [ [ "species_10318619", "catalyst" ] ], "additional_components": [ "F6WI63", "ENSXETT00000017597", "CHEBI:29035" ] }, "reaction_10311626": { "compartment": "compartment_5460", "id": "reaction_10311626", "reactome": "R-XTR-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113587", "species_113521" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10311623", "catalyst" ] ], "additional_components": [ "Q28DK1", "ENSXETT00000020990" ] }, "reaction_10311649": { "compartment": "compartment_5460", "id": "reaction_10311649", "reactome": "R-XTR-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10311646", "catalyst" ] ], "additional_components": [ "Q6P355", "ENSXETT00000057629", "B0BM36", "ENSXETG00000013435", "Q28ED0", "ENSXETT00000087904", "species_113596" ] }, "reaction_10311869": { "compartment": "compartment_70101", "id": "reaction_10311869", "reactome": "R-XTR-71732", "name": "pyrophosphate + H2O => 2 orthophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10311866", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "A0A6I8S9S0", "ENSXETG00000014102" ] }, "reaction_10318570": { "compartment": "compartment_5460", "id": "reaction_10318570", "reactome": "R-XTR-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159450", "species_113521" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10318567", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "A0A6I8S9S0", "ENSXETG00000014102" ] }, "reaction_10330207": { "compartment": "compartment_70101", "id": "reaction_10330207", "reactome": "R-XTR-5652195", "name": "SORD oxidizes D-sorbitol to Fru", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5652213", "species_29360" ], "products": [ "species_29532", "species_70106", "species_73473" ], "modifiers": [ [ "species_10330204", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8PMG1", "ENSXETG00000023897" ] }, "reaction_10337689": { "compartment": "compartment_161320", "id": "reaction_10337689", "reactome": "R-XTR-9036727", "name": "GAA hydrolyzes lysosomal glycogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_10337678" ], "products": [ "species_10337682", "species_1605745" ], "modifiers": [ [ "species_10337684", "catalyst" ] ], "additional_components": [ "A0A6I8SJ17", "ENSXETG00000016072", "CHEBI:29035", "CHEBI:29035", "A0A6I8SJ17", "ENSXETG00000016072", "ENSXETT00000002749" ] }, "reaction_10337919": { "compartment": "compartment_70101", "id": "reaction_10337919", "reactome": "R-XTR-9638125", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10337916", "catalyst" ] ], "additional_components": [ "species_109496", "F6PKQ4", "ENSXETT00000023697" ] }, "reaction_10311436": { "compartment": "compartment_70101", "id": "reaction_10311436", "reactome": "R-XTR-70467", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_30014", "species_29370" ], "modifiers": [ [ "species_10311433", "catalyst" ], [ "species_30533", "catalyst" ], [ "species_29370", "catalyst" ], [ "species_76577", "catalyst" ], [ "species_76190", "inhibitor" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "A0A6I8RGQ8", "ENSXETG00000007279" ] }, "reaction_10333611": { "compartment": "compartment_70101", "id": "reaction_10333611", "reactome": "R-XTR-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_449701" ], "products": [ "species_29512", "species_31633" ], "modifiers": [ [ "species_10333608", "catalyst" ] ], "additional_components": [ "A4IHW6", "ENSXETT00000018476" ] }, "reaction_10311418": { "compartment": "compartment_70101", "id": "reaction_10311418", "reactome": "R-XTR-70420", "name": "HK1,2,3,GCK phosphorylate Glc to form G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_70113" ], "products": [ "species_70106", "species_29370", "species_30537" ], "modifiers": [ [ "species_10311413", "catalyst" ] ], "additional_components": [ "ENSXETT00000005874" ] }, "reaction_10311878": { "compartment": "compartment_70101", "id": "reaction_10311878", "reactome": "R-XTR-71850", "name": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_29800" ], "products": [ "species_113592", "species_29728" ], "modifiers": [ [ "species_10311459", "catalyst" ] ], "additional_components": [ "A0A6I8SHY7", "ENSXETG00000007447", "species_109496" ] }, "reaction_10311427": { "compartment": "compartment_70101", "id": "reaction_10311427", "reactome": "R-XTR-70454", "name": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75970" ], "products": [ "species_29578" ], "modifiers": [ [ "species_10311424", "catalyst" ] ], "additional_components": [ "B0BM40", "ENSXETG00000023924" ] }, "reaction_10327532": { "compartment": "compartment_17957", "id": "reaction_10327532", "reactome": "R-XTR-3262512", "name": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_113782" ], "products": [ "species_113551", "species_113780" ], "modifiers": [ [ "species_10327529", "catalyst" ] ], "additional_components": [ "ENSXETG00000032824" ] }, "reaction_10311471": { "compartment": "compartment_5460", "id": "reaction_10311471", "reactome": "R-XTR-70501", "name": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113557", "species_29376" ], "products": [ "species_113548", "species_113581", "species_113587" ], "modifiers": [ [ "species_10311468", "catalyst" ], [ "species_113559", "catalyst" ] ], "additional_components": [ "CHEBI:29035", "A0A6I8QW74", "ENSXETG00000008415", "species_199207" ] }, "reaction_10314378": { "compartment": "compartment_70101", "id": "reaction_10314378", "reactome": "R-XTR-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_29360" ], "products": [ "species_70106", "species_76213", "species_73473" ], "modifiers": [ [ "species_10314375", "catalyst" ] ], "additional_components": [ "Q6DIY9", "ENSXETT00000101573" ] }, "reaction_10311445": { "compartment": "compartment_70101", "id": "reaction_10311445", "reactome": "R-XTR-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10311442", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "species_109496", "Q6P8F7", "ENSXETT00000049063" ] }, "reaction_10327525": { "compartment": "compartment_70101", "id": "reaction_10327525", "reactome": "R-XTR-3257122", "name": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113551", "species_30537" ], "products": [ "species_29372", "species_113782" ], "modifiers": [ [ "species_10327522", "catalyst" ] ], "additional_components": [ "ENSXETT00000094617" ] }, "reaction_10311876": { "compartment": "compartment_17957", "id": "reaction_10311876", "reactome": "R-XTR-71825", "name": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_113782" ], "products": [ "species_113551", "species_113780" ], "modifiers": [ [ "species_10311873", "catalyst" ] ], "additional_components": [ "ENSXETT00000033981" ] }, "reaction_10325949": { "compartment": "compartment_20699", "id": "reaction_10325949", "reactome": "R-XTR-2076419", "name": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10325677" ], "products": [ "species_742343", "species_10325691" ], "modifiers": [ [ "species_10325946", "catalyst" ] ], "additional_components": [ "Q0V9W0", "ENSXETT00000104077", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "ENSXETT00000011900" ] }, "reaction_10325593": { "compartment": "compartment_20699", "id": "reaction_10325593", "reactome": "R-XTR-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325590", "species_2022884" ], "products": [ "species_10325545", "species_2022890" ], "modifiers": [ [ "species_10325568", "catalyst" ] ], "additional_components": [ "A0A6I8R4L4", "ENSXETG00000039039", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8PYW4", "ENSXETG00000007104", "Q0V9W0", "ENSXETT00000104077", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "ENSXETG00000015804" ] }, "reaction_10319098": { "compartment": "compartment_20699", "id": "reaction_10319098", "reactome": "R-XTR-744231", "name": "SLC35D2 exchanges UDP-sugars for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744229", "species_735698" ], "products": [ "species_109402", "species_744234" ], "modifiers": [ [ "species_10319093", "catalyst" ] ], "additional_components": [ "species_744227", "species_162756", "species_744227", "species_162756", "ENSXETG00000041312" ] }, "reaction_10325767": { "compartment": "compartment_17963", "id": "reaction_10325767", "reactome": "R-XTR-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325693" ], "products": [ "species_10325765" ], "modifiers": [], "additional_components": [ "Q0V9W0", "ENSXETT00000104077", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8SBK0", "ENSXETG00000032333" ] }, "reaction_10325571": { "compartment": "compartment_20699", "id": "reaction_10325571", "reactome": "R-XTR-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10325545" ], "products": [ "species_742343", "species_10325564" ], "modifiers": [ [ "species_10325568", "catalyst" ] ], "additional_components": [ "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "Q0V9W0", "ENSXETT00000104077", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8R4L4", "ENSXETG00000039039", "ENSXETG00000015804" ] }, "reaction_10324079": { "compartment": "compartment_17938", "id": "reaction_10324079", "reactome": "R-XTR-1678660", "name": "HGSNAT oligomer acetylates Heparan sulfate chain(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090040", "species_76183" ], "products": [ "species_2090069", "species_76194" ], "modifiers": [ [ "species_10324076", "catalyst" ] ], "additional_components": [ "A0A6I8PYT1", "ENSXETG00000036665" ] }, "reaction_10325961": { "compartment": "compartment_161320", "id": "reaction_10325961", "reactome": "R-XTR-2090037", "name": "IDUA hydrolyses Heparan sulfate chain(6)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090055" ], "products": [ "species_2090070", "species_1678617" ], "modifiers": [ [ "species_10324111", "catalyst" ] ], "additional_components": [ "ENSXETG00000031913" ] }, "reaction_10325963": { "compartment": "compartment_17938", "id": "reaction_10325963", "reactome": "R-XTR-2090085", "name": "HGSNAT oligomer acetylates Heparan chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_2090045" ], "products": [ "species_2090053", "species_76194" ], "modifiers": [ [ "species_10324076", "catalyst" ] ], "additional_components": [ "A0A6I8PYT1", "ENSXETG00000036665" ] }, "reaction_10325601": { "compartment": "compartment_876", "id": "reaction_10325601", "reactome": "R-XTR-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324093" ], "products": [ "species_10323951" ], "modifiers": [], "additional_components": [ "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R5Q9", "ENSXETG00000035467", "Q0V9W0", "ENSXETT00000104077", "A0A6I8R4L4", "ENSXETG00000039039" ] }, "reaction_10324114": { "compartment": "compartment_161320", "id": "reaction_10324114", "reactome": "R-XTR-1678716", "name": "IDUA hydrolyses Heparan sulfate chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090033", "species_1605715" ], "products": [ "species_2090072", "species_1678617" ], "modifiers": [ [ "species_10324111", "catalyst" ] ], "additional_components": [ "ENSXETG00000031913" ] }, "reaction_10337912": { "compartment": "compartment_20699", "id": "reaction_10337912", "reactome": "R-XTR-9638064", "name": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10324414" ], "products": [ "species_10324442", "species_205687" ], "modifiers": [ [ "species_10324448", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8PV84", "ENSXETG00000015273", "F7DRX3", "ENSXETT00000049772", "CHEBI:29035" ] }, "reaction_10324451": { "compartment": "compartment_20699", "id": "reaction_10324451", "reactome": "R-XTR-1889955", "name": "B3GAT dimers transfer GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10324414" ], "products": [ "species_10324442", "species_205687" ], "modifiers": [ [ "species_10324448", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8R4L4", "ENSXETG00000039039", "Q0V9W0", "ENSXETT00000104077", "A0A6I8PV84", "ENSXETG00000015273", "F7DRX3", "ENSXETT00000049772", "CHEBI:29035" ] }, "reaction_10324386": { "compartment": "compartment_20699", "id": "reaction_10324386", "reactome": "R-XTR-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324351", "species_742361" ], "products": [ "species_10324379", "species_205687" ], "modifiers": [ [ "species_10324383", "catalyst" ] ], "additional_components": [ "Q0V9W0", "ENSXETT00000104077", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8SBK0", "ENSXETG00000032333", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8R4L4", "ENSXETG00000039039", "A0A6I8R5Q9", "ENSXETG00000035467", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8R4L4", "ENSXETG00000039039", "A0A6I8SBK0", "ENSXETG00000032333", "A4IIC2", "ENSXETT00000063928", "A0A6I8PYW4", "ENSXETG00000007104", "A0A6I8PV84", "ENSXETG00000015273", "Q0V9W0", "ENSXETT00000104077", "ENSXETG00000006839" ] }, "reaction_10325917": { "compartment": "compartment_984", "id": "reaction_10325917", "reactome": "R-XTR-2046239", "name": "Extracellular KSPG translocates to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325889" ], "products": [ "species_10324223" ], "modifiers": [], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260" ] }, "reaction_10325932": { "compartment": "compartment_20699", "id": "reaction_10325932", "reactome": "R-XTR-2046285", "name": "The keratan chain can be capped by N-acetylneuraminic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_10325925" ], "products": [ "species_10325894", "species_727810" ], "modifiers": [ [ "species_10325929", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "ENSXETG00000026104" ] }, "reaction_10325774": { "compartment": "compartment_20699", "id": "reaction_10325774", "reactome": "R-XTR-2025723", "name": "B4GALTs transfer Gal to the N-glycan precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10325769" ], "products": [ "species_205687", "species_10325772" ], "modifiers": [ [ "species_10320782", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "A0A6I8QS90", "ENSXETG00000034513" ] }, "reaction_10325934": { "compartment": "compartment_20699", "id": "reaction_10325934", "reactome": "R-XTR-2046298", "name": "B4GALTs transfer Gal to a branch of keratan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325920", "species_735682" ], "products": [ "species_10325925", "species_205687" ], "modifiers": [ [ "species_10320782", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "A0A6I8QS90", "ENSXETG00000034513" ] }, "reaction_10325915": { "compartment": "compartment_20699", "id": "reaction_10325915", "reactome": "R-XTR-2046222", "name": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10325894" ], "products": [ "species_742343", "species_10325885" ], "modifiers": [ [ "species_10325912", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "A0A6I8Q6E3", "ENSXETG00000040380", "A0A6I8PUA8", "ENSXETG00000034141" ] }, "reaction_10325780": { "compartment": "compartment_20699", "id": "reaction_10325780", "reactome": "R-XTR-2025724", "name": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10325772" ], "products": [ "species_10325777", "species_205687" ], "modifiers": [ [ "species_10320403", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "ENSXETG00000040687" ] }, "reaction_10325891": { "compartment": "compartment_17963", "id": "reaction_10325891", "reactome": "R-XTR-2046180", "name": "KSPG is secreted from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325887" ], "products": [ "species_10325889" ], "modifiers": [], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260" ] }, "reaction_10325922": { "compartment": "compartment_20699", "id": "reaction_10325922", "reactome": "R-XTR-2046265", "name": "B4GALTs transfer Gal to the keratan chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325777", "species_735682" ], "products": [ "species_10325920", "species_205687" ], "modifiers": [ [ "species_10320782", "catalyst" ] ], "additional_components": [ "ENSXETG00000040260", "ENSXETG00000040260", "A0A6I8QS90", "ENSXETG00000034513" ] }, "reaction_10326060": { "compartment": "compartment_161320", "id": "reaction_10326060", "reactome": "R-XTR-2160874", "name": "HYAL1 hydrolyses (HA)50", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2160864" ], "products": [ "species_2160866" ], "modifiers": [ [ "species_10324215", "catalyst" ] ], "additional_components": [ "species_2142867", "species_2142867", "ENSXETG00000040650" ] }, "reaction_10326088": { "compartment": "compartment_876", "id": "reaction_10326088", "reactome": "R-XTR-2160915", "name": "Receptor-mediated uptake of HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326064", "species_10326068", "species_2160848" ], "products": [ "species_10326070" ], "modifiers": [], "additional_components": [ "ENSXETG00000035220", "ENSXETT00000004761", "species_2142867", "species_2142867", "F7EIX5", "ENSXETT00000004761", "A0A6I8QK29", "ENSXETG00000035220" ] }, "reaction_10326086": { "compartment": "compartment_876", "id": "reaction_10326086", "reactome": "R-XTR-2160892", "name": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326083" ], "products": [ "species_2160894", "species_10326083" ], "modifiers": [ [ "species_10326083", "catalyst" ] ], "additional_components": [ "species_2142867", "F7EIX5", "ENSXETT00000004761", "A0A6I8QK29", "ENSXETG00000035220", "Q6DK70", "ENSXETT00000057366", "species_74112", "species_2142867", "species_2142867", "F7EIX5", "ENSXETT00000004761", "A0A6I8QK29", "ENSXETG00000035220", "Q6DK70", "ENSXETT00000057366", "species_74112", "species_2142867", "F7EIX5", "ENSXETT00000004761", "A0A6I8QK29", "ENSXETG00000035220", "Q6DK70", "ENSXETT00000057366", "species_74112" ] }, "reaction_10331295": { "compartment": "compartment_984", "id": "reaction_10331295", "reactome": "R-XTR-5693356", "name": "CEMIP hydrolyses HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2160848" ], "products": [ "species_5693343", "species_2160848" ], "modifiers": [ [ "species_10331292", "catalyst" ] ], "additional_components": [ "species_2142867", "species_2142867", "ENSXETG00000012981" ] }, "reaction_10326058": { "compartment": "compartment_876", "id": "reaction_10326058", "reactome": "R-XTR-2160851", "name": "HAS1,2,3 mediate the polymerisation of HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142867" ], "products": [ "species_2142896" ], "modifiers": [ [ "species_10326055", "catalyst" ] ], "additional_components": [ "species_2142867", "ENSXETG00000004083" ] }, "reaction_10325597": { "compartment": "compartment_17963", "id": "reaction_10325597", "reactome": "R-XTR-2022911", "name": "CSPG is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325595" ], "products": [ "species_10324884" ], "modifiers": [], "additional_components": [ "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928" ] }, "reaction_10324604": { "compartment": "compartment_20699", "id": "reaction_10324604", "reactome": "R-XTR-1971491", "name": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10324544" ], "products": [ "species_10324594", "species_205687" ], "modifiers": [ [ "species_10324598", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "ENSXETG00000030580" ] }, "reaction_10324796": { "compartment": "compartment_20699", "id": "reaction_10324796", "reactome": "R-XTR-2018682", "name": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10324555" ], "products": [ "species_742343", "species_10324789" ], "modifiers": [ [ "species_10324793", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "ENSXETG00000032713" ] }, "reaction_10324601": { "compartment": "compartment_20699", "id": "reaction_10324601", "reactome": "R-XTR-1971487", "name": "CHPF,CHSY3 transfer GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10324594" ], "products": [ "species_10324555", "species_205687" ], "modifiers": [ [ "species_10324598", "catalyst" ] ], "additional_components": [ "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "ENSXETG00000030580" ] }, "reaction_10324778": { "compartment": "compartment_20699", "id": "reaction_10324778", "reactome": "R-XTR-2018659", "name": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10324566" ], "products": [ "species_10324771", "species_742343" ], "modifiers": [ [ "species_10324775", "catalyst" ] ], "additional_components": [ "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "ENSXETT00000038652" ] }, "reaction_10337892": { "compartment": "compartment_20699", "id": "reaction_10337892", "reactome": "R-XTR-9632034", "name": "CHSY1 transfers GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10324544" ], "products": [ "species_10324594", "species_205687" ], "modifiers": [ [ "species_10337886", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "ENSXETG00000018744" ] }, "reaction_10324583": { "compartment": "compartment_20699", "id": "reaction_10324583", "reactome": "R-XTR-1971483", "name": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10324555" ], "products": [ "species_742343", "species_10324566" ], "modifiers": [ [ "species_10324580", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "Q28E26", "ENSXETT00000079954", "A0A6I8Q0S9", "ENSXETG00000001882", "A0A6I8PMV5", "ENSXETG00000027548" ] }, "reaction_10337889": { "compartment": "compartment_20699", "id": "reaction_10337889", "reactome": "R-XTR-9632033", "name": "CHSY1 transfers GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10324594" ], "products": [ "species_10324555", "species_205687" ], "modifiers": [ [ "species_10337886", "catalyst" ] ], "additional_components": [ "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "ENSXETG00000018744" ] }, "reaction_10324829": { "compartment": "compartment_20699", "id": "reaction_10324829", "reactome": "R-XTR-2022052", "name": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324798" ], "products": [ "species_10324822" ], "modifiers": [ [ "species_10324826", "catalyst" ] ], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A4IIC2", "ENSXETT00000063928", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "ENSXETT00000066016" ] }, "reaction_10324954": { "compartment": "compartment_17963", "id": "reaction_10324954", "reactome": "R-XTR-2022065", "name": "DSPGs are secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324952" ], "products": [ "species_10324858" ], "modifiers": [], "additional_components": [ "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928" ] }, "reaction_10324218": { "compartment": "compartment_161320", "id": "reaction_10324218", "reactome": "R-XTR-1793209", "name": "HYAL1 hydrolyses Chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065257" ], "products": [ "species_2065212" ], "modifiers": [ [ "species_10324215", "catalyst" ] ], "additional_components": [ "CHEBI:63512", "CHEBI:63513", "CHEBI:63515", "CHEBI:63511", "ENSXETG00000040650" ] }, "reaction_10324211": { "compartment": "compartment_161320", "id": "reaction_10324211", "reactome": "R-XTR-1793186", "name": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105025" ], "products": [ "species_2104993", "species_1678617" ], "modifiers": [ [ "species_10324111", "catalyst" ] ], "additional_components": [ "ENSXETG00000031913" ] }, "reaction_10324930": { "compartment": "compartment_984", "id": "reaction_10324930", "reactome": "R-XTR-2022056", "name": "DSPG and CSPG translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324884", "species_10324858" ], "products": [ "species_10324928", "species_10324910" ], "modifiers": [], "additional_components": [ "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273", "A4IIC2", "ENSXETT00000063928", "A4IIC2", "ENSXETT00000063928", "A0A6I8Q003", "ENSXETG00000014328", "A0A6I8PV84", "ENSXETG00000015273" ] }, "reaction_10330365": { "compartment": "compartment_70101", "id": "reaction_10330365", "reactome": "R-XTR-5662471", "name": "SORD tetramer oxidizes xylitol to D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5660033", "species_29360" ], "products": [ "species_70106", "species_5661281", "species_73473" ], "modifiers": [ [ "species_10330204", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8PMG1", "ENSXETG00000023897" ] }, "reaction_10330362": { "compartment": "compartment_70101", "id": "reaction_10330362", "reactome": "R-XTR-5661256", "name": "AKR1A1 reduces D-glucuronate to L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_5661264", "species_29364" ], "products": [ "species_29366", "species_5661268" ], "modifiers": [ [ "species_10330359", "catalyst" ] ], "additional_components": [ "ENSXETT00000007570" ] }, "reaction_10311741": { "compartment": "compartment_70101", "id": "reaction_10311741", "reactome": "R-XTR-71334", "name": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29882" ], "products": [ "species_29512", "species_29878" ], "modifiers": [ [ "species_10311738", "catalyst" ] ], "additional_components": [ "A0A6I8SUP4", "ENSXETG00000025887" ] }, "reaction_10311732": { "compartment": "compartment_70101", "id": "reaction_10311732", "reactome": "R-XTR-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31467" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10311729", "catalyst" ] ], "additional_components": [ "ENSXETG00000038389" ] }, "reaction_10335154": { "compartment": "compartment_161320", "id": "reaction_10335154", "reactome": "R-XTR-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_1678743", "species_6799594" ], "modifiers": [ [ "species_10335151", "catalyst" ] ], "additional_components": [ "ENSXETG00000002247" ] }, "reaction_10337628": { "compartment": "compartment_70101", "id": "reaction_10337628", "reactome": "R-XTR-9033959", "name": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_9033793" ], "products": [ "species_205687", "species_9033802" ], "modifiers": [ [ "species_10337625", "catalyst" ] ], "additional_components": [ "A0A6I8SLE8", "ENSXETG00000038208", "CHEBI:29035" ] }, "reaction_10337694": { "compartment": "compartment_17963", "id": "reaction_10337694", "reactome": "R-XTR-9036987", "name": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9037036" ], "modifiers": [ [ "species_10337691", "catalyst" ] ], "additional_components": [ "ENSXETG00000041078" ] }, "reaction_10337646": { "compartment": "compartment_984", "id": "reaction_10337646", "reactome": "R-XTR-9034042", "name": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9034101", "species_9034046" ], "products": [ "species_417888", "species_9037066" ], "modifiers": [ [ "species_10337643", "catalyst" ] ], "additional_components": [ "A0A6I8SLE8", "ENSXETG00000038208", "CHEBI:29035" ] }, "reaction_10337653": { "compartment": "compartment_984", "id": "reaction_10337653", "reactome": "R-XTR-9034053", "name": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9034101", "species_9034065" ], "products": [ "species_417888", "species_9037067" ], "modifiers": [ [ "species_10337650", "catalyst" ] ], "additional_components": [ "CHEBI:29035", "A0A6I8SLE8", "ENSXETG00000038208" ] }, "reaction_10337639": { "compartment": "compartment_70101", "id": "reaction_10337639", "reactome": "R-XTR-9033961", "name": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_9033793" ], "products": [ "species_9033798", "species_205687" ], "modifiers": [ [ "species_10337636", "catalyst" ] ], "additional_components": [ "CHEBI:29035", "A0A6I8SLE8", "ENSXETG00000038208" ] }, "reaction_10337619": { "compartment": "compartment_17963", "id": "reaction_10337619", "reactome": "R-XTR-9033949", "name": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_205689", "species_9033793" ], "modifiers": [ [ "species_10337616", "catalyst" ] ], "additional_components": [ "ENSXETG00000041078" ] }, "reaction_10337740": { "compartment": "compartment_17963", "id": "reaction_10337740", "reactome": "R-XTR-9605600", "name": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_9033790" ], "products": [ "species_727810", "species_9605685" ], "modifiers": [ [ "species_10325929", "catalyst" ] ], "additional_components": [ "ENSXETG00000026104" ] }, "reaction_10337743": { "compartment": "compartment_17963", "id": "reaction_10337743", "reactome": "R-XTR-9605609", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605595", "species_205683" ], "products": [ "species_9605615", "species_205689" ], "modifiers": [ [ "species_10331319", "catalyst" ] ], "additional_components": [ "ENSXETG00000032714" ] }, "reaction_10337721": { "compartment": "compartment_17963", "id": "reaction_10337721", "reactome": "R-XTR-9603984", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9605593", "species_205689" ], "modifiers": [ [ "species_10337718", "catalyst" ] ], "additional_components": [ "A0A6I8PN52", "ENSXETG00000037458", "A0A6I8PQF9", "ENSXETG00000032714" ] }, "reaction_10337736": { "compartment": "compartment_17963", "id": "reaction_10337736", "reactome": "R-XTR-9603989", "name": "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9604808", "species_735682" ], "products": [ "species_205687", "species_9036984" ], "modifiers": [ [ "species_10337733", "catalyst" ] ], "additional_components": [ "A0A6I8PS91", "ENSXETG00000040256", "A0A6I8PVV6", "ENSXETG00000040256" ] }, "reaction_10337723": { "compartment": "compartment_17963", "id": "reaction_10337723", "reactome": "R-XTR-9603986", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9605607" ], "modifiers": [ [ "species_10331319", "catalyst" ] ], "additional_components": [ "ENSXETG00000032714" ] }, "reaction_10337749": { "compartment": "compartment_17963", "id": "reaction_10337749", "reactome": "R-XTR-9605682", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605685", "species_205683" ], "products": [ "species_9605661", "species_205689" ], "modifiers": [ [ "species_10331319", "catalyst" ] ], "additional_components": [ "ENSXETG00000032714" ] }, "reaction_10337700": { "compartment": "compartment_17963", "id": "reaction_10337700", "reactome": "R-XTR-9603983", "name": "FUT2 transfers Fuc to LeX to form LeY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605593", "species_205683" ], "products": [ "species_205689", "species_9605586" ], "modifiers": [ [ "species_10337691", "catalyst" ] ], "additional_components": [ "ENSXETG00000041078" ] }, "reaction_10337751": { "compartment": "compartment_17963", "id": "reaction_10337751", "reactome": "R-XTR-9605700", "name": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_9605685" ], "products": [ "species_205687", "species_9605718" ], "modifiers": [ [ "species_10335255", "catalyst" ] ], "additional_components": [ "ENSXETG00000033376" ] }, "reaction_10337745": { "compartment": "compartment_17963", "id": "reaction_10337745", "reactome": "R-XTR-9605644", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605649", "species_205683" ], "products": [ "species_205689", "species_9605651" ], "modifiers": [ [ "species_10331319", "catalyst" ] ], "additional_components": [ "ENSXETG00000032714" ] }, "reaction_10337698": { "compartment": "compartment_17963", "id": "reaction_10337698", "reactome": "R-XTR-9603982", "name": "FUT2 transfers Fuc to LeA to form LeB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605607", "species_205683" ], "products": [ "species_205689", "species_9605394" ], "modifiers": [ [ "species_10337691", "catalyst" ] ], "additional_components": [ "ENSXETG00000041078" ] }, "reaction_10322454": { "compartment": "compartment_5460", "id": "reaction_10322454", "reactome": "R-XTR-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113531", "species_10322452" ], "products": [ "species_10322436" ], "modifiers": [], "additional_components": [ "A0A6I8R145", "ENSXETG00000039175", "A0A6I8Q5L5", "ENSXETG00000038488", "Q6P633", "ENSXETT00000057208", "A0A6I8Q5L5", "ENSXETG00000038488", "Q6P633", "ENSXETT00000057208", "A0A6I8R145", "ENSXETG00000039175", "species_435347" ] }, "reaction_10322449": { "compartment": "compartment_5460", "id": "reaction_10322449", "reactome": "R-XTR-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379721", "species_10322436", "species_10322442" ], "products": [ "species_379697", "species_10322446", "species_10322444" ], "modifiers": [ [ "species_10322436", "catalyst" ], [ "species_10322442", "catalyst" ] ], "additional_components": [ "A0A6I8Q5L5", "ENSXETG00000038488", "Q6P633", "ENSXETT00000057208", "A0A6I8R145", "ENSXETG00000039175", "species_435347", "CHEBI:33738", "F7CAB2", "ENSXETT00000030454", "F7CAB2", "ENSXETT00000030454", "CHEBI:33737", "A0A6I8R145", "ENSXETG00000039175", "A0A6I8Q5L5", "ENSXETG00000038488", "Q6P633", "ENSXETT00000057208", "CHEBI:33739", "A0A6I8Q5L5", "ENSXETG00000038488", "Q6P633", "ENSXETT00000057208", "A0A6I8R145", "ENSXETG00000039175", "species_435347", "CHEBI:33738", "F7CAB2", "ENSXETT00000030454" ] }, "reaction_10336048": { "compartment": "compartment_5460", "id": "reaction_10336048", "reactome": "R-XTR-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336040", "species_10336030" ], "products": [ "species_10336042", "species_10336028" ], "modifiers": [ [ "species_10336046", "catalyst" ] ], "additional_components": [ "A0A6I8PNK1", "ENSXETG00000031871", "A0A6I8PY88", "ENSXETG00000030839", "Q6DJ11", "ENSXETT00000054920", "CHEBI:33739", "A0A6I8PNK1", "ENSXETG00000031871", "A0A6I8PY88", "ENSXETG00000030839", "CHEBI:49883", "ENSXETT00000054920", "ENSXETG00000026948" ] }, "reaction_10317263": { "compartment": "compartment_876", "id": "reaction_10317263", "reactome": "R-XTR-381713", "name": "Potassium voltage-gated channels close in reponse to PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317261" ], "products": [ "species_10317261" ], "modifiers": [], "additional_components": [ "A0A6I8PNT1", "ENSXETG00000032745", "A0A6I8PSS9", "ENSXETG00000015573", "A0A6I8PNT1", "ENSXETG00000032745", "A0A6I8PSS9", "ENSXETG00000015573" ] }, "reaction_10317251": { "compartment": "compartment_12045", "id": "reaction_10317251", "reactome": "R-XTR-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317243" ], "products": [ "species_10317249" ], "modifiers": [], "additional_components": [ "F6XEN8", "ENSXETT00000003958", "A0A6I8QV43", "ENSXETG00000005153", "species_114520", "A0A6I8QV43", "ENSXETG00000005153", "F6XEN8", "ENSXETT00000003958" ] }, "reaction_10317267": { "compartment": "compartment_70101", "id": "reaction_10317267", "reactome": "R-XTR-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10317265" ], "products": [ "species_29420", "species_10316760" ], "modifiers": [], "additional_components": [ "species_29420", "Q640R7", "ENSXETT00000104159", "Q640R7", "ENSXETT00000104159", "species_29438" ] }, "reaction_10335625": { "compartment": "compartment_70101", "id": "reaction_10335625", "reactome": "R-XTR-8862380", "name": "HSD17B13 binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331297", "species_8866926" ], "products": [ "species_10335623" ], "modifiers": [], "additional_components": [ "ENSXETT00000002941", "species_171126", "species_163579", "species_171142", "species_171126", "species_163579", "species_171142", "A8WGW3", "ENSXETT00000002941" ] }, "reaction_10335344": { "compartment": "compartment_12045", "id": "reaction_10335344", "reactome": "R-XTR-8857686", "name": "FITM1, FITM2 bind TAGs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549167", "species_10335340" ], "products": [ "species_10335342" ], "modifiers": [], "additional_components": [ "ENSXETG00000001773", "A0JP80", "ENSXETG00000001773", "species_171126" ] }, "reaction_10331439": { "compartment": "compartment_12045", "id": "reaction_10331439", "reactome": "R-XTR-5696119", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_5696122", "species_29368" ], "products": [ "species_29356", "species_1497857", "species_76116", "species_5696116" ], "modifiers": [ [ "species_10331436", "catalyst" ] ], "additional_components": [ "ENSXETG00000005052" ] }, "reaction_10333674": { "compartment": "compartment_12045", "id": "reaction_10333674", "reactome": "R-XTR-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76103", "species_76194" ], "modifiers": [ [ "species_10333671", "catalyst" ] ], "additional_components": [ "Q5M8H5", "ENSXETT00000008697", "Q28C88", "ENSXETG00000002935" ] }, "reaction_10319045": { "compartment": "compartment_70101", "id": "reaction_10319045", "reactome": "R-XTR-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10319042", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10323897": { "compartment": "compartment_876", "id": "reaction_10323897", "reactome": "R-XTR-1606583", "name": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429807" ], "products": [ "species_1606609", "species_1861754" ], "modifiers": [ [ "species_10323894", "catalyst" ] ], "additional_components": [] }, "reaction_10323915": { "compartment": "compartment_20699", "id": "reaction_10323915", "reactome": "R-XTR-1638104", "name": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744227", "species_428270" ], "products": [ "species_1660674", "species_205687" ], "modifiers": [ [ "species_10323912", "catalyst" ] ], "additional_components": [ "ENSXETT00000084396" ] }, "reaction_10329573": { "compartment": "compartment_70101", "id": "reaction_10329573", "reactome": "R-XTR-5339535", "name": "GLTPD1 transports C1P from plasma membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1638840" ], "products": [ "species_5339515" ], "modifiers": [ [ "species_10329570", "catalyst" ] ], "additional_components": [ "ENSXETT00000024361" ] }, "reaction_10323888": { "compartment": "compartment_161320", "id": "reaction_10323888", "reactome": "R-XTR-1606564", "name": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1606573" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10323885", "catalyst" ] ], "additional_components": [ "ENSXETG00000016608" ] }, "reaction_10323922": { "compartment": "compartment_876", "id": "reaction_10323922", "reactome": "R-XTR-1638845", "name": "CERK phosphorylates CERA to form C1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_113592" ], "products": [ "species_29370", "species_1638840" ], "modifiers": [ [ "species_10323919", "catalyst" ] ], "additional_components": [ "ENSXETG00000030525" ] }, "reaction_10318077": { "compartment": "compartment_70101", "id": "reaction_10318077", "reactome": "R-XTR-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_428126", "species_29368" ], "products": [ "species_428218", "species_29356", "species_428256" ], "modifiers": [ [ "species_10318074", "catalyst" ] ], "additional_components": [ "species_73473", "species_113600", "species_29360", "species_113563", "ENSXETT00000040228" ] }, "reaction_10318094": { "compartment": "compartment_70101", "id": "reaction_10318094", "reactome": "R-XTR-428701", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10318088", "catalyst" ] ], "additional_components": [ "ENSXETG00000030642" ] }, "reaction_10318091": { "compartment": "compartment_70101", "id": "reaction_10318091", "reactome": "R-XTR-428664", "name": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428275" ], "products": [ "species_29372", "species_428694" ], "modifiers": [ [ "species_10318088", "catalyst" ] ], "additional_components": [ "ENSXETG00000030642" ] }, "reaction_10336999": { "compartment": "compartment_12045", "id": "reaction_10336999", "reactome": "R-XTR-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959490", "species_8959486" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10336996", "catalyst" ] ], "additional_components": [ "ENSXETT00000042961" ] }, "reaction_10318070": { "compartment": "compartment_70101", "id": "reaction_10318070", "reactome": "R-XTR-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_428163" ], "products": [ "species_428126", "species_76194" ], "modifiers": [ [ "species_10318067", "catalyst" ] ], "additional_components": [ "ENSXETT00000029263" ] }, "reaction_10331218": { "compartment": "compartment_12045", "id": "reaction_10331218", "reactome": "R-XTR-5692261", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428671", "species_29360" ], "products": [ "species_70106", "species_3632881", "species_73473" ], "modifiers": [ [ "species_10331215", "catalyst" ] ], "additional_components": [ "F6X8Y6", "ENSXETT00000029530" ] }, "reaction_10314156": { "compartment": "compartment_70101", "id": "reaction_10314156", "reactome": "R-XTR-191303", "name": "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191409", "species_191362" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10314153", "catalyst" ] ], "additional_components": [ "species_109496", "A0A6I8QKN8", "ENSXETG00000040625" ] }, "reaction_10314159": { "compartment": "compartment_70101", "id": "reaction_10314159", "reactome": "R-XTR-191322", "name": "Addition of isopentenyl pyrophosphate to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191324", "species_191362" ], "products": [ "species_111294", "species_191409" ], "modifiers": [ [ "species_10314153", "catalyst" ] ], "additional_components": [ "species_109496", "A0A6I8QKN8", "ENSXETG00000040625" ] }, "reaction_10314175": { "compartment": "compartment_70101", "id": "reaction_10314175", "reactome": "R-XTR-191366", "name": "Squalene 2,3-epoxide cyclizes, forming lanosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191309" ], "products": [ "species_194634" ], "modifiers": [ [ "species_10314172", "catalyst" ] ], "additional_components": [ "ENSXETT00000043201" ] }, "reaction_10314168": { "compartment": "compartment_70101", "id": "reaction_10314168", "reactome": "R-XTR-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374", "species_70106", "species_29364" ], "products": [ "species_29366", "species_76194", "species_191424" ], "modifiers": [ [ "species_10314165", "catalyst" ] ], "additional_components": [ "A0A6I8REP9", "ENSXETG00000005084" ] }, "reaction_10314315": { "compartment": "compartment_13231", "id": "reaction_10314315", "reactome": "R-XTR-194674", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194681", "species_194725", "species_194688" ], "products": [ "species_194668", "species_194704" ], "modifiers": [ [ "species_10314312", "catalyst" ] ], "additional_components": [ "ENSXETG00000034786" ] }, "reaction_10329482": { "compartment": "compartment_17957", "id": "reaction_10329482", "reactome": "R-XTR-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10329479", "catalyst" ] ], "additional_components": [ "ENSXETT00000055609" ] }, "reaction_10314344": { "compartment": "compartment_70101", "id": "reaction_10314344", "reactome": "R-XTR-196417", "name": "Reduction of desmosterol to cholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_196420", "species_29364" ], "products": [ "species_193384", "species_29366" ], "modifiers": [ [ "species_10314341", "catalyst" ] ], "additional_components": [ "ENSXETG00000020010" ] }, "reaction_10314337": { "compartment": "compartment_70101", "id": "reaction_10314337", "reactome": "R-XTR-196402", "name": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_195655", "species_29364" ], "products": [ "species_29366", "species_196420" ], "modifiers": [ [ "species_10314334", "catalyst" ] ], "additional_components": [ "ENSXETG00000008945" ] }, "reaction_10314322": { "compartment": "compartment_70101", "id": "reaction_10314322", "reactome": "R-XTR-195664", "name": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_195691", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_195655" ], "modifiers": [ [ "species_10314319", "catalyst" ] ], "additional_components": [ "ENSXETG00000040073" ] }, "reaction_10336886": { "compartment": "compartment_70101", "id": "reaction_10336886", "reactome": "R-XTR-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_191265" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10336883", "catalyst" ] ], "additional_components": [ "ENSXETT00000041334" ] }, "reaction_10335903": { "compartment": "compartment_70101", "id": "reaction_10335903", "reactome": "R-XTR-8873850", "name": "STARD5 binds DCA, LCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_10335899", "species_5357505" ], "products": [ "species_10335901" ], "modifiers": [], "additional_components": [ "ENSXETG00000030995", "species_5357505", "A0A6I8PZC4", "ENSXETG00000030995", "species_176655" ] }, "reaction_10313015": { "compartment": "compartment_70101", "id": "reaction_10313015", "reactome": "R-XTR-159431", "name": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194073", "species_194069" ], "products": [ "species_193416", "species_76194" ], "modifiers": [ [ "species_10313012", "catalyst" ] ], "additional_components": [ "species_192356", "species_193472", "species_159549", "CHEBI:15891", "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:28865", "ENSXETT00000000095" ] }, "reaction_10335837": { "compartment": "compartment_70101", "id": "reaction_10335837", "reactome": "R-XTR-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10335834", "catalyst" ] ], "additional_components": [ "Q0IJ05", "ENSXETG00000002831", "A0A6I8SCX9", "ENSXETG00000015011" ] }, "reaction_10314190": { "compartment": "compartment_5460", "id": "reaction_10314190", "reactome": "R-XTR-191999", "name": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_192078", "species_113529", "species_113600" ], "products": [ "species_192201", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314213": { "compartment": "compartment_5460", "id": "reaction_10314213", "reactome": "R-XTR-192042", "name": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192201", "species_113563" ], "products": [ "species_113529", "species_191968", "species_113600" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314261": { "compartment": "compartment_17951", "id": "reaction_10314261", "reactome": "R-XTR-193491", "name": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193463", "species_193472" ], "products": [ "species_193453", "species_193514" ], "modifiers": [ [ "species_10314228", "catalyst" ] ], "additional_components": [ "species_159549", "CHEBI:15891", "CHEBI:36274", "CHEBI:16525", "ENSXETT00000000095" ] }, "reaction_10314263": { "compartment": "compartment_5460", "id": "reaction_10314263", "reactome": "R-XTR-193497", "name": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_193387" ], "products": [ "species_193435", "species_113529", "species_113600" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314215": { "compartment": "compartment_5460", "id": "reaction_10314215", "reactome": "R-XTR-192054", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_191968", "species_113600" ], "products": [ "species_113563", "species_192161", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314231": { "compartment": "compartment_17951", "id": "reaction_10314231", "reactome": "R-XTR-192312", "name": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192356", "species_193463" ], "products": [ "species_193404", "species_193514" ], "modifiers": [ [ "species_10314228", "catalyst" ] ], "additional_components": [ "species_159549", "CHEBI:15891", "CHEBI:17687", "CHEBI:28865", "ENSXETT00000000095" ] }, "reaction_10314257": { "compartment": "compartment_5460", "id": "reaction_10314257", "reactome": "R-XTR-193393", "name": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193436", "species_113533", "species_113529", "species_113600" ], "products": [ "species_113563", "species_193387", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314211": { "compartment": "compartment_70101", "id": "reaction_10314211", "reactome": "R-XTR-192036", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192064" ], "products": [ "species_29366", "species_192087" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10314259": { "compartment": "compartment_5460", "id": "reaction_10314259", "reactome": "R-XTR-193460", "name": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_193435", "species_113529", "species_113600" ], "products": [ "species_113563", "species_193440", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314226": { "compartment": "compartment_70101", "id": "reaction_10314226", "reactome": "R-XTR-192160", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191980", "species_70106", "species_29364" ], "products": [ "species_192030", "species_29366" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10335848": { "compartment": "compartment_70101", "id": "reaction_10335848", "reactome": "R-XTR-8868402", "name": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399", "species_1806217" ], "products": [ "species_8868393", "species_1806234" ], "modifiers": [ [ "species_10335845", "catalyst" ] ], "additional_components": [ "ENSXETG00000020714" ] }, "reaction_10314269": { "compartment": "compartment_5460", "id": "reaction_10314269", "reactome": "R-XTR-193719", "name": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193708", "species_113533", "species_113529", "species_113600" ], "products": [ "species_113563", "species_193716", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314271": { "compartment": "compartment_5460", "id": "reaction_10314271", "reactome": "R-XTR-193737", "name": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_193716", "species_113600" ], "products": [ "species_193757", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314281": { "compartment": "compartment_5460", "id": "reaction_10314281", "reactome": "R-XTR-193792", "name": "CYP27A1 27-hydroxylates 5-CHOL3,7,24(s)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_193720", "species_113529", "species_113600" ], "products": [ "species_193708", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314267": { "compartment": "compartment_5460", "id": "reaction_10314267", "reactome": "R-XTR-193713", "name": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_193785", "species_113529", "species_113600" ], "products": [ "species_113563", "species_193747", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314277": { "compartment": "compartment_70101", "id": "reaction_10314277", "reactome": "R-XTR-193781", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193707", "species_29364" ], "products": [ "species_29366", "species_193728" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10314279": { "compartment": "compartment_5460", "id": "reaction_10314279", "reactome": "R-XTR-193787", "name": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_193777", "species_113600" ], "products": [ "species_113563", "species_193782", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314273": { "compartment": "compartment_70101", "id": "reaction_10314273", "reactome": "R-XTR-193758", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193760" ], "products": [ "species_29366", "species_213285" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10314275": { "compartment": "compartment_5460", "id": "reaction_10314275", "reactome": "R-XTR-193780", "name": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_193782", "species_113600" ], "products": [ "species_193785", "species_113563", "species_113521" ], "modifiers": [ [ "species_10314187", "catalyst" ] ], "additional_components": [ "ENSXETG00000039601" ] }, "reaction_10314285": { "compartment": "compartment_70101", "id": "reaction_10314285", "reactome": "R-XTR-193841", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193830" ], "products": [ "species_29366", "species_193842" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10314283": { "compartment": "compartment_70101", "id": "reaction_10314283", "reactome": "R-XTR-193800", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193829", "species_29364" ], "products": [ "species_29366", "species_193843" ], "modifiers": [ [ "species_10314208", "catalyst" ] ], "additional_components": [ "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10331300": { "compartment": "compartment_70101", "id": "reaction_10331300", "reactome": "R-XTR-5693390", "name": "HSD17B11 dehydrogenates EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193132", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10331297", "catalyst" ] ], "additional_components": [ "ENSXETT00000002941" ] }, "reaction_10334610": { "compartment": "compartment_70101", "id": "reaction_10334610", "reactome": "R-XTR-6810594", "name": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176619", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10334607", "catalyst" ] ], "additional_components": [ "A0A6I8S4B9", "ENSXETG00000035086" ] }, "reaction_10314330": { "compartment": "compartment_70616", "id": "reaction_10314330", "reactome": "R-XTR-196086", "name": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314328" ], "products": [ "species_10314326", "species_193156" ], "modifiers": [], "additional_components": [ "species_216762", "F7C998", "ENSXETT00000006725", "ENSXETT00000006725" ] }, "reaction_10338216": { "compartment": "compartment_70101", "id": "reaction_10338216", "reactome": "R-XTR-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10328552", "catalyst" ] ], "additional_components": [ "ENSXETG00000021063" ] }, "reaction_10338213": { "compartment": "compartment_70101", "id": "reaction_10338213", "reactome": "R-XTR-9705713", "name": "SRD5A2 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10338210", "catalyst" ] ], "additional_components": [ "ENSXETG00000025082" ] }, "reaction_10314308": { "compartment": "compartment_17957", "id": "reaction_10314308", "reactome": "R-XTR-194023", "name": "HSD11B2,HSD11B1 dimer oxidise CORT to COR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193977", "species_29366" ], "products": [ "species_70106", "species_29364", "species_194035" ], "modifiers": [ [ "species_10314305", "catalyst" ] ], "additional_components": [ "A4IGM4", "ENSXETT00000031363" ] }, "reaction_10322500": { "compartment": "compartment_984", "id": "reaction_10322500", "reactome": "R-XTR-1449687", "name": "Corticosteroids bind to CBG in blood", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1449707", "species_10322496" ], "products": [ "species_10322498" ], "modifiers": [], "additional_components": [ "species_193982", "CHEBI:17026", "species_194011", "species_193988", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350", "A0A6I8QL92", "ENSXETG00000039008", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350", "A0A6I8QL92", "ENSXETG00000039008", "species_193982", "CHEBI:17026", "species_194011", "species_193988" ] }, "reaction_10319038": { "compartment": "compartment_70101", "id": "reaction_10319038", "reactome": "R-XTR-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_548836", "species_29366" ], "modifiers": [ [ "species_10319035", "catalyst" ] ], "additional_components": [ "ENSXETT00000048094" ] }, "reaction_10315643": { "compartment": "compartment_70101", "id": "reaction_10315643", "reactome": "R-XTR-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3632881", "species_76194" ], "products": [ "species_111294", "species_29356", "species_200993", "species_76577" ], "modifiers": [ [ "species_10315640", "catalyst" ] ], "additional_components": [ "ENSXETG00000016588" ] }, "reaction_10319031": { "compartment": "compartment_70101", "id": "reaction_10319031", "reactome": "R-XTR-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_113528", "species_548812", "species_76194" ], "modifiers": [ [ "species_10319028", "catalyst" ] ], "additional_components": [ "ENSXETG00000035907" ] }, "reaction_10319024": { "compartment": "compartment_70101", "id": "reaction_10319024", "reactome": "R-XTR-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_29508" ], "products": [ "species_113528", "species_548816", "species_76194" ], "modifiers": [ [ "species_10319021", "catalyst" ] ], "additional_components": [ "ENSXETT00000034904" ] }, "reaction_10330576": { "compartment": "compartment_12045", "id": "reaction_10330576", "reactome": "R-XTR-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_29356", "species_5676634" ], "modifiers": [ [ "species_10330573", "catalyst" ] ], "additional_components": [ "A0A6I8T2J8", "ENSXETG00000040752" ] }, "reaction_10334601": { "compartment": "compartment_17951", "id": "reaction_10334601", "reactome": "R-XTR-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10334598", "catalyst" ] ], "additional_components": [ "ENSXETT00000054418" ] }, "reaction_10334696": { "compartment": "compartment_17947", "id": "reaction_10334696", "reactome": "R-XTR-8848247", "name": "ACBD4,5 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690520", "species_10334692" ], "products": [ "species_10334694" ], "modifiers": [], "additional_components": [ "CHEBI:33184", "CHEBI:61907", "Q640U0", "ENSXETT00000040674", "Q640U0", "ENSXETT00000040674", "CHEBI:33184", "CHEBI:61907" ] }, "reaction_10317404": { "compartment": "compartment_17947", "id": "reaction_10317404", "reactome": "R-XTR-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10317281", "catalyst" ] ], "additional_components": [ "A0A6I8Q353", "ENSXETG00000007705" ] }, "reaction_10330926": { "compartment": "compartment_17951", "id": "reaction_10330926", "reactome": "R-XTR-5690042", "name": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690520", "species_141343" ], "products": [ "species_5690539", "species_193514" ], "modifiers": [ [ "species_10330921", "catalyst" ] ], "additional_components": [ "CHEBI:33184", "CHEBI:61907", "CHEBI:59554", "species_30495", "ENSXETT00000000095" ] }, "reaction_10334585": { "compartment": "compartment_17951", "id": "reaction_10334585", "reactome": "R-XTR-6809808", "name": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6809801" ], "products": [ "species_6809800" ], "modifiers": [ [ "species_10334582", "catalyst" ] ], "additional_components": [ "A0A6I8RBB6", "ENSXETG00000032831" ] }, "reaction_10332329": { "compartment": "compartment_17951", "id": "reaction_10332329", "reactome": "R-XTR-6786720", "name": "DECR2 reduces LCtE-CoA to t3enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193465", "species_6786723", "species_113602" ], "products": [ "species_6786715", "species_389556" ], "modifiers": [ [ "species_10332326", "catalyst" ] ], "additional_components": [ "ENSXETT00000022727" ] }, "reaction_10334554": { "compartment": "compartment_17951", "id": "reaction_10334554", "reactome": "R-XTR-6809264", "name": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10334548", "catalyst" ] ], "additional_components": [ "ENSXETT00000023381" ] }, "reaction_10334551": { "compartment": "compartment_17951", "id": "reaction_10334551", "reactome": "R-XTR-6809263", "name": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_390249" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10334548", "catalyst" ] ], "additional_components": [ "ENSXETT00000023381" ] }, "reaction_10320834": { "compartment": "compartment_17951", "id": "reaction_10320834", "reactome": "R-XTR-977317", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977323" ], "products": [ "species_353123", "species_389536" ], "modifiers": [ [ "species_10320831", "catalyst" ] ], "additional_components": [ "ENSXETG00000013233" ] }, "reaction_10317365": { "compartment": "compartment_17951", "id": "reaction_10317365", "reactome": "R-XTR-389609", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389636", "species_192307" ], "products": [ "species_193465", "species_6811612", "species_192305" ], "modifiers": [ [ "species_10317362", "catalyst" ] ], "additional_components": [ "F6X8Y6", "ENSXETT00000029530" ] }, "reaction_10317391": { "compartment": "compartment_17951", "id": "reaction_10317391", "reactome": "R-XTR-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10317388", "catalyst" ] ], "additional_components": [ "species_113596", "A0A6I8PRN9", "ENSXETG00000031495" ] }, "reaction_10325882": { "compartment": "compartment_12045", "id": "reaction_10325882", "reactome": "R-XTR-2046100", "name": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046059", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046057", "species_162743", "species_159751" ], "modifiers": [ [ "species_10319021", "catalyst" ] ], "additional_components": [ "ENSXETT00000034904" ] }, "reaction_10325876": { "compartment": "compartment_17957", "id": "reaction_10325876", "reactome": "R-XTR-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046051", "species_162743", "species_159751" ], "modifiers": [ [ "species_10319021", "catalyst" ] ], "additional_components": [ "ENSXETT00000034904" ] }, "reaction_10325874": { "compartment": "compartment_17957", "id": "reaction_10325874", "reactome": "R-XTR-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_426639", "species_211606", "species_2046047" ], "modifiers": [ [ "species_10317279", "catalyst" ] ], "additional_components": [ "ENSXETG00000007705" ] }, "reaction_10326111": { "compartment": "compartment_12045", "id": "reaction_10326111", "reactome": "R-XTR-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2142739" ], "modifiers": [ [ "species_10326101", "catalyst" ] ], "additional_components": [ "A0A6I8SJ30", "ENSXETG00000038590", "A4IGV4", "ENSXETT00000061279" ] }, "reaction_10326116": { "compartment": "compartment_12045", "id": "reaction_10326116", "reactome": "R-XTR-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_2161753", "species_29366" ], "modifiers": [ [ "species_10326113", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "A0A6I8SJ30", "ENSXETG00000038590", "A0A6I8PUP3", "ENSXETG00000033706", "A4IGV4", "ENSXETT00000061279" ] }, "reaction_10326136": { "compartment": "compartment_70101", "id": "reaction_10326136", "reactome": "R-XTR-2161950", "name": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2142790" ], "modifiers": [ [ "species_10326133", "catalyst" ] ], "additional_components": [ "species_435347", "A0A6I8QVI1", "ENSXETG00000018683", "A0A6I8R9T5", "ENSXETG00000000004" ] }, "reaction_10336762": { "compartment": "compartment_70101", "id": "reaction_10336762", "reactome": "R-XTR-8942208", "name": "ALOXE3 isomerises 12R-HpETE to HXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142790" ], "products": [ "species_8942209" ], "modifiers": [ [ "species_10336759", "catalyst" ] ], "additional_components": [ "A0A6I8R9T5", "ENSXETG00000000004", "A0A6I8QVI1", "ENSXETG00000018683" ] }, "reaction_10331492": { "compartment": "compartment_12045", "id": "reaction_10331492", "reactome": "R-XTR-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192172", "species_5696426" ], "products": [ "species_5696412", "species_162743" ], "modifiers": [ [ "species_10331489", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10326094": { "compartment": "compartment_70101", "id": "reaction_10326094", "reactome": "R-XTR-2161614", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_879629" ], "products": [ "species_29366", "species_2142710" ], "modifiers": [ [ "species_10314206", "catalyst" ] ], "additional_components": [ "A0A6I8R8Y6", "ENSXETG00000040684", "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10326091": { "compartment": "compartment_70101", "id": "reaction_10326091", "reactome": "R-XTR-2161549", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_265283", "species_29364" ], "products": [ "species_29366", "species_879535" ], "modifiers": [ [ "species_10314206", "catalyst" ] ], "additional_components": [ "A0A6I8R8Y6", "ENSXETG00000040684", "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10326099": { "compartment": "compartment_70101", "id": "reaction_10326099", "reactome": "R-XTR-2161701", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_879629" ], "modifiers": [ [ "species_10326096", "catalyst" ] ], "additional_components": [ "F6SJ37", "ENSXETT00000045440", "species_1247892" ] }, "reaction_10326143": { "compartment": "compartment_70101", "id": "reaction_10326143", "reactome": "R-XTR-2162002", "name": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2142718" ], "modifiers": [ [ "species_10326140", "catalyst" ] ], "additional_components": [ "A0A6I8QVI1", "ENSXETG00000018683", "species_435347" ] }, "reaction_10312563": { "compartment": "compartment_12045", "id": "reaction_10312563", "reactome": "R-XTR-111883", "name": "Hydrolysis of phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_140356", "species_428981" ], "modifiers": [ [ "species_10312558", "catalyst" ] ], "additional_components": [ "B1WAZ6", "ENSXETT00000066288", "species_74112", "species_426925" ] }, "reaction_10335800": { "compartment": "compartment_70101", "id": "reaction_10335800", "reactome": "R-XTR-8866941", "name": "MID1IP1 binds THRSP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335794", "species_10335796" ], "products": [ "species_10335798" ], "modifiers": [], "additional_components": [ "ENSXETT00000087898", "ENSXETT00000087898", "Q6P8B2", "ENSXETT00000087898" ] }, "reaction_10315632": { "compartment": "compartment_70616", "id": "reaction_10315632", "reactome": "R-XTR-200410", "name": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_201050" ], "products": [ "species_201023", "species_77281" ], "modifiers": [ [ "species_10315629", "catalyst" ] ], "additional_components": [ "ENSXETT00000017686" ] }, "reaction_10330939": { "compartment": "compartment_70101", "id": "reaction_10330939", "reactome": "R-XTR-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5690044" ], "products": [ "species_5690064", "species_76194" ], "modifiers": [ [ "species_10330936", "catalyst" ] ], "additional_components": [ "CHEBI:61907", "CHEBI:33184", "CHEBI:59554", "species_30495", "Q6DER5", "ENSXETT00000054972", "F6UBG9", "ENSXETT00000000095" ] }, "reaction_10330950": { "compartment": "compartment_5460", "id": "reaction_10330950", "reactome": "R-XTR-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10330947", "catalyst" ] ], "additional_components": [ "CHEBI:33184", "CHEBI:61907", "species_30495", "CHEBI:59554", "F6UBG9", "ENSXETT00000000095", "A0A6I8RQ71", "ENSXETG00000036041" ] }, "reaction_10336900": { "compartment": "compartment_5460", "id": "reaction_10336900", "reactome": "R-XTR-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113529", "species_113600" ], "products": [ "species_77308", "species_113563" ], "modifiers": [ [ "species_10336897", "catalyst" ] ], "additional_components": [ "Q28GQ2", "ENSXETT00000031439" ] }, "reaction_10324062": { "compartment": "compartment_876", "id": "reaction_10324062", "reactome": "R-XTR-1676164", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10324057", "catalyst" ] ], "additional_components": [ "ENSXETG00000019407" ] }, "reaction_10324025": { "compartment": "compartment_876", "id": "reaction_10324025", "reactome": "R-XTR-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10324015", "catalyst" ] ], "additional_components": [ "ENSXETG00000009899" ] }, "reaction_10323994": { "compartment": "compartment_876", "id": "reaction_10323994", "reactome": "R-XTR-1675780", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_392417" ], "modifiers": [ [ "species_10323991", "catalyst" ] ], "additional_components": [ "Q28G26", "ENSXETG00000000962", "Q505I0", "ENSXETG00000013516" ] }, "reaction_10324053": { "compartment": "compartment_876", "id": "reaction_10324053", "reactome": "R-XTR-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10323969", "catalyst" ] ], "additional_components": [ "ENSXETT00000042073" ] }, "reaction_10324020": { "compartment": "compartment_876", "id": "reaction_10324020", "reactome": "R-XTR-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10324015", "catalyst" ] ], "additional_components": [ "ENSXETG00000009899" ] }, "reaction_10324048": { "compartment": "compartment_876", "id": "reaction_10324048", "reactome": "R-XTR-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10312068", "catalyst" ] ], "additional_components": [ "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252" ] }, "reaction_10323981": { "compartment": "compartment_876", "id": "reaction_10323981", "reactome": "R-XTR-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806240", "species_113592" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10323978", "catalyst" ] ], "additional_components": [ "Q6GL14", "ENSXETG00000006229" ] }, "reaction_10324043": { "compartment": "compartment_876", "id": "reaction_10324043", "reactome": "R-XTR-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10323969", "catalyst" ] ], "additional_components": [ "ENSXETT00000042073" ] }, "reaction_10324037": { "compartment": "compartment_876", "id": "reaction_10324037", "reactome": "R-XTR-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10312068", "catalyst" ] ], "additional_components": [ "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252" ] }, "reaction_10323972": { "compartment": "compartment_876", "id": "reaction_10323972", "reactome": "R-XTR-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10323969", "catalyst" ] ], "additional_components": [ "ENSXETT00000042073" ] }, "reaction_10324070": { "compartment": "compartment_876", "id": "reaction_10324070", "reactome": "R-XTR-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10324031", "catalyst" ] ], "additional_components": [ "A0A6I8QJY3", "ENSXETG00000016428", "A0A6I8RPT3", "ENSXETG00000009899" ] }, "reaction_10324065": { "compartment": "compartment_876", "id": "reaction_10324065", "reactome": "R-XTR-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10324015", "catalyst" ] ], "additional_components": [ "ENSXETG00000009899" ] }, "reaction_10324034": { "compartment": "compartment_876", "id": "reaction_10324034", "reactome": "R-XTR-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10324031", "catalyst" ] ], "additional_components": [ "A0A6I8QJY3", "ENSXETG00000016428", "A0A6I8RPT3", "ENSXETG00000009899" ] }, "reaction_10324045": { "compartment": "compartment_171062", "id": "reaction_10324045", "reactome": "R-XTR-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806205" ], "products": [ "species_29372", "species_1806259" ], "modifiers": [ [ "species_10323998", "catalyst" ] ], "additional_components": [ "ENSXETT00000011460" ] }, "reaction_10324060": { "compartment": "compartment_171062", "id": "reaction_10324060", "reactome": "R-XTR-1676162", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806238" ], "products": [ "species_29372", "species_1806200" ], "modifiers": [ [ "species_10324057", "catalyst" ] ], "additional_components": [ "ENSXETG00000019407" ] }, "reaction_10324022": { "compartment": "compartment_171062", "id": "reaction_10324022", "reactome": "R-XTR-1675974", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_1806180", "species_29370" ], "modifiers": [ [ "species_10323991", "catalyst" ] ], "additional_components": [ "Q28G26", "ENSXETG00000000962", "Q505I0", "ENSXETG00000013516" ] }, "reaction_10324050": { "compartment": "compartment_171062", "id": "reaction_10324050", "reactome": "R-XTR-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10323998", "catalyst" ] ], "additional_components": [ "ENSXETT00000011460" ] }, "reaction_10334562": { "compartment": "compartment_70101", "id": "reaction_10334562", "reactome": "R-XTR-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334558", "species_10323998" ], "products": [ "species_10334560" ], "modifiers": [], "additional_components": [ "ENSXETG00000015585", "ENSXETT00000011460", "F6VED7", "ENSXETT00000011460", "A0A6I8R2K2", "ENSXETG00000015585" ] }, "reaction_10334573": { "compartment": "compartment_70101", "id": "reaction_10334573", "reactome": "R-XTR-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5676030" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10334568", "catalyst" ] ], "additional_components": [ "F6VED7", "ENSXETT00000011460", "A0A6I8Q167", "ENSXETG00000023079" ] }, "reaction_10334570": { "compartment": "compartment_70101", "id": "reaction_10334570", "reactome": "R-XTR-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334566", "species_10323998" ], "products": [ "species_10334568" ], "modifiers": [], "additional_components": [ "ENSXETG00000023079", "ENSXETT00000011460", "F6VED7", "ENSXETT00000011460", "A0A6I8Q167", "ENSXETG00000023079" ] }, "reaction_10324004": { "compartment": "compartment_12045", "id": "reaction_10324004", "reactome": "R-XTR-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10323989", "catalyst" ] ], "additional_components": [ "ENSXETG00000000962" ] }, "reaction_10334576": { "compartment": "compartment_70101", "id": "reaction_10334576", "reactome": "R-XTR-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6809774" ], "products": [ "species_29372", "species_422529" ], "modifiers": [ [ "species_10334568", "catalyst" ] ], "additional_components": [ "F6VED7", "ENSXETT00000011460", "A0A6I8Q167", "ENSXETG00000023079" ] }, "reaction_10324011": { "compartment": "compartment_20699", "id": "reaction_10324011", "reactome": "R-XTR-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_29372", "species_1806217" ], "modifiers": [ [ "species_10324008", "catalyst" ] ], "additional_components": [ "ENSXETG00000038322" ] }, "reaction_10324067": { "compartment": "compartment_20699", "id": "reaction_10324067", "reactome": "R-XTR-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10323991", "catalyst" ] ], "additional_components": [ "Q28G26", "ENSXETG00000000962", "Q505I0", "ENSXETG00000013516" ] }, "reaction_10335920": { "compartment": "compartment_437051", "id": "reaction_10335920", "reactome": "R-XTR-8874470", "name": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8874484" ], "products": [ "species_8874460" ], "modifiers": [ [ "species_10335917", "catalyst" ] ], "additional_components": [ "species_179838", "species_179856", "species_179856", "species_179838", "A0A6I8R443", "ENSXETG00000036250" ] }, "reaction_10324040": { "compartment": "compartment_172574", "id": "reaction_10324040", "reactome": "R-XTR-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10323998", "catalyst" ] ], "additional_components": [ "ENSXETT00000011460" ] }, "reaction_10324001": { "compartment": "compartment_172574", "id": "reaction_10324001", "reactome": "R-XTR-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_29372", "species_1806195" ], "modifiers": [ [ "species_10323998", "catalyst" ] ], "additional_components": [ "ENSXETT00000011460" ] }, "reaction_10335862": { "compartment": "compartment_70101", "id": "reaction_10335862", "reactome": "R-XTR-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_1602448" ], "products": [ "species_426755", "species_426658" ], "modifiers": [ [ "species_10335859", "catalyst" ] ], "additional_components": [ "ENSXETG00000020679" ] }, "reaction_10323390": { "compartment": "compartment_70101", "id": "reaction_10323390", "reactome": "R-XTR-1483096", "name": "PETA is dephosphorylated to ETA by PHOSPHO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428686" ], "products": [ "species_29372", "species_1498751" ], "modifiers": [ [ "species_10323387", "catalyst" ] ], "additional_components": [ "A0A6I8PRS6", "ENSXETG00000033588", "species_109496" ] }, "reaction_10323403": { "compartment": "compartment_70101", "id": "reaction_10323403", "reactome": "R-XTR-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10323371", "catalyst" ] ], "additional_components": [ "A0A6I8PNM3", "ENSXETG00000031132" ] }, "reaction_10323365": { "compartment": "compartment_12045", "id": "reaction_10323365", "reactome": "R-XTR-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_1500581", "species_109395" ], "modifiers": [ [ "species_10323362", "catalyst" ] ], "additional_components": [ "Q28H54", "ENSXETT00000009560", "species_109496", "CHEBI:29035", "A0A6I8QF66", "ENSXETG00000036824" ] }, "reaction_10323400": { "compartment": "compartment_12045", "id": "reaction_10323400", "reactome": "R-XTR-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_264618", "species_1500646" ], "modifiers": [ [ "species_10323397", "catalyst" ] ], "additional_components": [ "ENSXETG00000036605" ] }, "reaction_10323381": { "compartment": "compartment_12045", "id": "reaction_10323381", "reactome": "R-XTR-1483089", "name": "PE is converted to PS by PTDSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_1500581" ], "products": [ "species_1498751", "species_1500646" ], "modifiers": [ [ "species_10323378", "catalyst" ] ], "additional_components": [ "ENSXETG00000027078" ] }, "reaction_10323309": { "compartment": "compartment_70616", "id": "reaction_10323309", "reactome": "R-XTR-1482794", "name": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524072", "species_1524079" ], "products": [ "species_1524075", "species_1498773" ], "modifiers": [ [ "species_10323303", "catalyst" ] ], "additional_components": [ "ENSXETT00000007327" ] }, "reaction_10323341": { "compartment": "compartment_70616", "id": "reaction_10323341", "reactome": "R-XTR-1482894", "name": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524072", "species_1524089" ], "products": [ "species_1524083", "species_1498773" ], "modifiers": [ [ "species_10323303", "catalyst" ] ], "additional_components": [ "ENSXETT00000007327" ] }, "reaction_10323290": { "compartment": "compartment_70616", "id": "reaction_10323290", "reactome": "R-XTR-1482759", "name": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_113521" ], "products": [ "species_1498753", "species_1524085" ], "modifiers": [ [ "species_10323287", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323332": { "compartment": "compartment_12045", "id": "reaction_10323332", "reactome": "R-XTR-1482867", "name": "DLCL is acylated to MLCL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524080", "species_1500578" ], "products": [ "species_76194", "species_1524069" ], "modifiers": [ [ "species_10312131", "catalyst" ] ], "additional_components": [ "ENSXETT00000031524" ] }, "reaction_10323328": { "compartment": "compartment_12045", "id": "reaction_10323328", "reactome": "R-XTR-1482861", "name": "MLCL is acylated to CL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1524069" ], "products": [ "species_1524081", "species_76194" ], "modifiers": [ [ "species_10312131", "catalyst" ] ], "additional_components": [ "ENSXETT00000031524" ] }, "reaction_10331497": { "compartment": "compartment_12045", "id": "reaction_10331497", "reactome": "R-XTR-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10331494", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10323338": { "compartment": "compartment_12045", "id": "reaction_10323338", "reactome": "R-XTR-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10319042", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10334710": { "compartment": "compartment_12045", "id": "reaction_10334710", "reactome": "R-XTR-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10334707", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10323276": { "compartment": "compartment_12045", "id": "reaction_10323276", "reactome": "R-XTR-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498722" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323343": { "compartment": "compartment_12045", "id": "reaction_10323343", "reactome": "R-XTR-1482897", "name": "PS is hydrolyzed to 2-acyl LPS by PLA2[10]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500646" ], "products": [ "species_1498722", "species_1524021" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323299": { "compartment": "compartment_12045", "id": "reaction_10323299", "reactome": "R-XTR-1482771", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[9]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500646" ], "products": [ "species_1524021", "species_1498724" ], "modifiers": [ [ "species_10323296", "catalyst" ] ], "additional_components": [ "A0A6I8PMU8", "ENSXETG00000029956", "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323266": { "compartment": "compartment_12045", "id": "reaction_10323266", "reactome": "R-XTR-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498724" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323810": { "compartment": "compartment_984", "id": "reaction_10323810", "reactome": "R-XTR-1602374", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_33625" ], "products": [ "species_1602419", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10336015": { "compartment": "compartment_5460", "id": "reaction_10336015", "reactome": "R-XTR-8878654", "name": "ACP6 hydrolyses MYS-LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8878649", "species_113521" ], "products": [ "species_113548", "species_8934414" ], "modifiers": [ [ "species_10336012", "catalyst" ] ], "additional_components": [ "ENSXETT00000009623" ] }, "reaction_10312153": { "compartment": "compartment_70101", "id": "reaction_10312153", "reactome": "R-XTR-75889", "name": "DHAP is converted to G3P by GPD1/GPD1L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75970", "species_73473" ], "products": [ "species_76114", "species_29360" ], "modifiers": [ [ "species_10312150", "catalyst" ] ], "additional_components": [ "F6XXP1", "ENSXETT00000038446", "Q6P824", "ENSXETT00000032859" ] }, "reaction_10312136": { "compartment": "compartment_12045", "id": "reaction_10312136", "reactome": "R-XTR-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_426755", "species_76194" ], "modifiers": [ [ "species_10312133", "catalyst" ] ], "additional_components": [ "Q28C60", "ENSXETT00000037017", "F7A464", "ENSXETT00000031524" ] }, "reaction_10323256": { "compartment": "compartment_17906", "id": "reaction_10323256", "reactome": "R-XTR-1482604", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500590" ], "products": [ "species_1500580", "species_1524103" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10336024": { "compartment": "compartment_984", "id": "reaction_10336024", "reactome": "R-XTR-8878787", "name": "ALPI dimer hydrolyses phosphate monoesters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8878780" ], "products": [ "species_8878776", "species_109277" ], "modifiers": [ [ "species_10336021", "catalyst" ] ], "additional_components": [ "species_29426", "species_74112", "A0A6I8RU07", "ENSXETG00000032063" ] }, "reaction_10332427": { "compartment": "compartment_876", "id": "reaction_10332427", "reactome": "R-XTR-6792445", "name": "LIPH, I hydrolyse PA to 2-acyl LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602448" ], "products": [ "species_6792472", "species_1602366" ], "modifiers": [ [ "species_10332424", "catalyst" ] ], "additional_components": [ "Q5XGE9", "ENSXETG00000005849", "F6XB15", "ENSXETT00000048464", "L7N2H3", "ENSXETT00000002050" ] }, "reaction_10336954": { "compartment": "compartment_17906", "id": "reaction_10336954", "reactome": "R-XTR-8954398", "name": "PLD6 dimer hydrolyses cardiolipin to PA and PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189422", "species_8954419" ], "products": [ "species_8954401", "species_1500590" ], "modifiers": [ [ "species_10336945", "catalyst" ], [ "species_10336952", "catalyst" ] ], "additional_components": [ "Q28DT3", "ENSXETG00000005747", "A0A6I8QVP8", "ENSXETG00000018962" ] }, "reaction_10323818": { "compartment": "compartment_984", "id": "reaction_10323818", "reactome": "R-XTR-1602446", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602448" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10323270": { "compartment": "compartment_70101", "id": "reaction_10323270", "reactome": "R-XTR-1482656", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323283": { "compartment": "compartment_17906", "id": "reaction_10323283", "reactome": "R-XTR-1482695", "name": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_76194", "species_1500580" ], "modifiers": [ [ "species_10323280", "catalyst" ] ], "additional_components": [ "ENSXETG00000033567" ] }, "reaction_10332322": { "compartment": "compartment_70101", "id": "reaction_10332322", "reactome": "R-XTR-6786650", "name": "DDHD1,2 hydrolyse PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1602448" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10332319", "catalyst" ] ], "additional_components": [ "A0A6I8SK52", "ENSXETG00000015184", "A0A6I8QC54", "ENSXETG00000038294" ] }, "reaction_10323321": { "compartment": "compartment_12045", "id": "reaction_10323321", "reactome": "R-XTR-1482828", "name": "PE is hydrolyzed to 2-acyl LPE by PLA2[4]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498729", "species_1524021" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323336": { "compartment": "compartment_12045", "id": "reaction_10323336", "reactome": "R-XTR-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10323313", "catalyst" ] ], "additional_components": [ "ENSXETG00000015758" ] }, "reaction_10323272": { "compartment": "compartment_12045", "id": "reaction_10323272", "reactome": "R-XTR-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498738" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10335402": { "compartment": "compartment_70101", "id": "reaction_10335402", "reactome": "R-XTR-8858298", "name": "HRASLS transfer acyl group from PC to PE to form NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_1500581" ], "products": [ "species_5694568", "species_6814253" ], "modifiers": [ [ "species_10335399", "catalyst" ] ], "additional_components": [ "A0A6I8PMU8", "ENSXETG00000029956", "A0A6I8SG35", "ENSXETG00000035934", "A0A6I8RYC6", "ENSXETG00000038318", "A0A6I8Q9S3", "ENSXETG00000035934" ] }, "reaction_10323268": { "compartment": "compartment_12045", "id": "reaction_10323268", "reactome": "R-XTR-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323334": { "compartment": "compartment_12045", "id": "reaction_10323334", "reactome": "R-XTR-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10323296", "catalyst" ] ], "additional_components": [ "A0A6I8PMU8", "ENSXETG00000029956", "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323814": { "compartment": "compartment_984", "id": "reaction_10323814", "reactome": "R-XTR-1602398", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602375", "species_109276" ], "products": [ "species_1602372", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10323262": { "compartment": "compartment_12045", "id": "reaction_10323262", "reactome": "R-XTR-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10323248", "catalyst" ] ], "additional_components": [ "ENSXETG00000036938" ] }, "reaction_10323812": { "compartment": "compartment_984", "id": "reaction_10323812", "reactome": "R-XTR-1602377", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_426658" ], "products": [ "species_1602420", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10323318": { "compartment": "compartment_12045", "id": "reaction_10323318", "reactome": "R-XTR-1482825", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[11]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426639" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10323296", "catalyst" ] ], "additional_components": [ "A0A6I8PMU8", "ENSXETG00000029956", "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323251": { "compartment": "compartment_12045", "id": "reaction_10323251", "reactome": "R-XTR-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10323248", "catalyst" ] ], "additional_components": [ "ENSXETG00000036938" ] }, "reaction_10323259": { "compartment": "compartment_12045", "id": "reaction_10323259", "reactome": "R-XTR-1482612", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_975614" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323274": { "compartment": "compartment_12045", "id": "reaction_10323274", "reactome": "R-XTR-1482685", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1524028" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323374": { "compartment": "compartment_70101", "id": "reaction_10323374", "reactome": "R-XTR-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_113592" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10323371", "catalyst" ] ], "additional_components": [ "A0A6I8PNM3", "ENSXETG00000031132" ] }, "reaction_10318360": { "compartment": "compartment_984", "id": "reaction_10318360", "reactome": "R-XTR-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10318357", "catalyst" ] ], "additional_components": [ "ENSXETG00000002987" ] }, "reaction_10323354": { "compartment": "compartment_12045", "id": "reaction_10323354", "reactome": "R-XTR-1482961", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524060", "species_1500596" ], "products": [ "species_426925", "species_109395" ], "modifiers": [ [ "species_10323351", "catalyst" ] ], "additional_components": [ "Q28H54", "ENSXETT00000009560", "species_109496", "CHEBI:29035" ] }, "reaction_10323393": { "compartment": "compartment_70101", "id": "reaction_10323393", "reactome": "R-XTR-1483159", "name": "PCho is dephosphorylated to Cho by PHOSPHO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1524071" ], "products": [ "species_264618", "species_29372" ], "modifiers": [ [ "species_10323387", "catalyst" ] ], "additional_components": [ "A0A6I8PRS6", "ENSXETG00000033588", "species_109496" ] }, "reaction_10335730": { "compartment": "compartment_984", "id": "reaction_10335730", "reactome": "R-XTR-8865637", "name": "MFSD2A transports LPC from extracellular region to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8865642", "species_74113" ], "products": [ "species_8865629", "species_83910" ], "modifiers": [ [ "species_10335727", "catalyst" ] ], "additional_components": [ "ENSXETT00000002564" ] }, "reaction_10323325": { "compartment": "compartment_12045", "id": "reaction_10323325", "reactome": "R-XTR-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10323296", "catalyst" ] ], "additional_components": [ "A0A6I8PMU8", "ENSXETG00000029956", "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323244": { "compartment": "compartment_12045", "id": "reaction_10323244", "reactome": "R-XTR-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323816": { "compartment": "compartment_984", "id": "reaction_10323816", "reactome": "R-XTR-1602417", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_429802" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10323316": { "compartment": "compartment_12045", "id": "reaction_10323316", "reactome": "R-XTR-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10323313", "catalyst" ] ], "additional_components": [ "ENSXETG00000015758" ] }, "reaction_10323239": { "compartment": "compartment_12045", "id": "reaction_10323239", "reactome": "R-XTR-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_975614" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323330": { "compartment": "compartment_12045", "id": "reaction_10323330", "reactome": "R-XTR-1482862", "name": "PC is hydrolysed to 2-acyl LPC by PLA2[7]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524021", "species_975614" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323242": { "compartment": "compartment_12045", "id": "reaction_10323242", "reactome": "R-XTR-1482539", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498740" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323345": { "compartment": "compartment_12045", "id": "reaction_10323345", "reactome": "R-XTR-1482900", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1524021", "species_1498740" ], "modifiers": [ [ "species_10323253", "catalyst" ] ], "additional_components": [ "species_74112", "B1WAZ6", "ENSXETT00000066288" ] }, "reaction_10323264": { "compartment": "compartment_12045", "id": "reaction_10323264", "reactome": "R-XTR-1482635", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498730", "species_1500578" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10312127", "catalyst" ] ], "additional_components": [ "ENSXETT00000037017" ] }, "reaction_10323808": { "compartment": "compartment_984", "id": "reaction_10323808", "reactome": "R-XTR-1602368", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602402" ], "products": [ "species_1602415", "species_1602366" ], "modifiers": [ [ "species_10323805", "catalyst" ] ], "additional_components": [ "species_74112", "Q28GM9", "ENSXETT00000083864", "F6TK24", "ENSXETT00000024072" ] }, "reaction_10311977": { "compartment": "compartment_5460", "id": "reaction_10311977", "reactome": "R-XTR-74181", "name": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_73871" ], "products": [ "species_113559" ], "modifiers": [ [ "species_10311582", "catalyst" ] ], "additional_components": [ "Q5BKN8", "ENSXETT00000031684" ] }, "reaction_10311959": { "compartment": "compartment_5460", "id": "reaction_10311959", "reactome": "R-XTR-73920", "name": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_73911" ], "products": [ "species_113529", "species_73909", "species_29362" ], "modifiers": [ [ "species_10311952", "catalyst" ] ], "additional_components": [ "F6RPR3", "ENSXETT00000007485" ] }, "reaction_10331407": { "compartment": "compartment_70101", "id": "reaction_10331407", "reactome": "R-XTR-5694494", "name": "AACS ligates CoA-SH to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_29666" ], "products": [ "species_111294", "species_191293", "species_76577" ], "modifiers": [ [ "species_10331404", "catalyst" ] ], "additional_components": [ "ENSXETG00000001210" ] }, "reaction_10335941": { "compartment": "compartment_5460", "id": "reaction_10335941", "reactome": "R-XTR-8875071", "name": "ACSS3 ligates CoA to CH3COO-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_113539" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10335938", "catalyst" ] ], "additional_components": [ "ENSXETG00000014528" ] }, "reaction_10332359": { "compartment": "compartment_70101", "id": "reaction_10332359", "reactome": "R-XTR-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_76183", "species_29666" ], "modifiers": [ [ "species_10332356", "catalyst" ] ], "additional_components": [ "species_109496", "A0A6I8PVX1", "ENSXETG00000007070" ] }, "reaction_10311955": { "compartment": "compartment_5460", "id": "reaction_10311955", "reactome": "R-XTR-73912", "name": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_73909", "species_29362" ], "products": [ "species_113526", "species_73911" ], "modifiers": [ [ "species_10311952", "catalyst" ] ], "additional_components": [ "F6RPR3", "ENSXETT00000007485" ] }, "reaction_10331506": { "compartment": "compartment_70101", "id": "reaction_10331506", "reactome": "R-XTR-5696457", "name": "BDH2 dehydrogenates 3HBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696461", "species_29360" ], "products": [ "species_70106", "species_29666", "species_73473" ], "modifiers": [ [ "species_10331503", "catalyst" ] ], "additional_components": [ "A0A6I8RES0", "ENSXETG00000021320" ] }, "reaction_10337487": { "compartment": "compartment_70101", "id": "reaction_10337487", "reactome": "R-XTR-9020255", "name": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024765" ], "products": [ "species_9024768", "species_29364" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337499": { "compartment": "compartment_70101", "id": "reaction_10337499", "reactome": "R-XTR-9020282", "name": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024765" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337493": { "compartment": "compartment_70101", "id": "reaction_10337493", "reactome": "R-XTR-9020264", "name": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024797" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337495": { "compartment": "compartment_70101", "id": "reaction_10337495", "reactome": "R-XTR-9020277", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024797" ], "products": [ "species_29364", "species_9024781" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337485": { "compartment": "compartment_70101", "id": "reaction_10337485", "reactome": "R-XTR-9020251", "name": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024463" ], "products": [ "species_9024479" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337497": { "compartment": "compartment_70101", "id": "reaction_10337497", "reactome": "R-XTR-9020278", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024576", "species_29366" ], "products": [ "species_9024577", "species_29364" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337489": { "compartment": "compartment_70101", "id": "reaction_10337489", "reactome": "R-XTR-9020256", "name": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024479" ], "products": [ "species_29364", "species_9024602" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337491": { "compartment": "compartment_70101", "id": "reaction_10337491", "reactome": "R-XTR-9020259", "name": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024463" ], "products": [ "species_9024576" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337534": { "compartment": "compartment_70101", "id": "reaction_10337534", "reactome": "R-XTR-9024997", "name": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025012", "species_29368" ], "products": [ "species_9024989" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337565": { "compartment": "compartment_70101", "id": "reaction_10337565", "reactome": "R-XTR-9027321", "name": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9027049" ], "products": [ "species_29356", "species_29366", "species_9027324" ], "modifiers": [ [ "species_10312165", "catalyst" ] ], "additional_components": [ "CHEBI:137368", "CHEBI:137361", "ENSXETG00000033706" ] }, "reaction_10337560": { "compartment": "compartment_70101", "id": "reaction_10337560", "reactome": "R-XTR-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9024011" ], "products": [ "species_29356", "species_29366", "species_9027049" ], "modifiers": [ [ "species_10337557", "catalyst" ] ], "additional_components": [ "A4IGV4", "ENSXETT00000061279", "A0A6I8PUP3", "ENSXETG00000033706", "F7B981", "ENSXETT00000026362", "A0A6I8Q6H5", "ENSXETT00000026362" ] }, "reaction_10337563": { "compartment": "compartment_70101", "id": "reaction_10337563", "reactome": "R-XTR-9027302", "name": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9027029", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_9027326", "species_29366" ], "modifiers": [ [ "species_10312165", "catalyst" ] ], "additional_components": [ "CHEBI:137360", "CHEBI:137354", "ENSXETG00000033706" ] }, "reaction_10337696": { "compartment": "compartment_12045", "id": "reaction_10337696", "reactome": "R-XTR-9037761", "name": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024886", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_9037755" ], "modifiers": [ [ "species_10312224", "catalyst" ] ], "additional_components": [ "ENSXETT00000061279" ] }, "reaction_10337555": { "compartment": "compartment_70101", "id": "reaction_10337555", "reactome": "R-XTR-9026911", "name": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024768" ], "products": [ "species_9026915" ], "modifiers": [ [ "species_10337550", "catalyst" ] ], "additional_components": [ "A0A6I8QSM3", "ENSXETG00000036146" ] }, "reaction_10337553": { "compartment": "compartment_70101", "id": "reaction_10337553", "reactome": "R-XTR-9026780", "name": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9025001" ], "products": [ "species_9026761" ], "modifiers": [ [ "species_10337550", "catalyst" ] ], "additional_components": [ "A0A6I8QSM3", "ENSXETG00000036146" ] }, "reaction_10337567": { "compartment": "compartment_70101", "id": "reaction_10337567", "reactome": "R-XTR-9027624", "name": "ALOX5 oxidises DHA to 7-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024011" ], "products": [ "species_9028274" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337569": { "compartment": "compartment_70101", "id": "reaction_10337569", "reactome": "R-XTR-9027628", "name": "ALOX5 oxidises EPA to 5-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2026977", "species_29368" ], "products": [ "species_9028283" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337571": { "compartment": "compartment_70101", "id": "reaction_10337571", "reactome": "R-XTR-9027633", "name": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9608444", "species_29368" ], "products": [ "species_9028240" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337542": { "compartment": "compartment_70101", "id": "reaction_10337542", "reactome": "R-XTR-9026005", "name": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026293", "species_29368" ], "products": [ "species_9026311" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337544": { "compartment": "compartment_70101", "id": "reaction_10337544", "reactome": "R-XTR-9026405", "name": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026400", "species_29368" ], "products": [ "species_9026394" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "CHEBI:137020", "CHEBI:137011", "CHEBI:137018", "CHEBI:137019", "ENSXETG00000007490" ] }, "reaction_10337540": { "compartment": "compartment_70101", "id": "reaction_10337540", "reactome": "R-XTR-9025999", "name": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9026047" ], "products": [ "species_9026046", "species_29364" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337536": { "compartment": "compartment_70101", "id": "reaction_10337536", "reactome": "R-XTR-9025995", "name": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026034", "species_29366" ], "products": [ "species_9026050", "species_29364" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337538": { "compartment": "compartment_70101", "id": "reaction_10337538", "reactome": "R-XTR-9025996", "name": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9026047" ], "products": [ "species_9026034" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337481": { "compartment": "compartment_70101", "id": "reaction_10337481", "reactome": "R-XTR-9018863", "name": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023651", "species_29368" ], "products": [ "species_9023702" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337483": { "compartment": "compartment_70101", "id": "reaction_10337483", "reactome": "R-XTR-9018894", "name": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023702", "species_29368" ], "products": [ "species_9023708" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337477": { "compartment": "compartment_70101", "id": "reaction_10337477", "reactome": "R-XTR-9018858", "name": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9020474" ], "products": [ "species_9020602" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10337479": { "compartment": "compartment_70101", "id": "reaction_10337479", "reactome": "R-XTR-9018859", "name": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9020602" ], "products": [ "species_9022655" ], "modifiers": [ [ "species_10318105", "catalyst" ] ], "additional_components": [ "ENSXETG00000007490" ] }, "reaction_10312123": { "compartment": "compartment_70101", "id": "reaction_10312123", "reactome": "R-XTR-75883", "name": "DHRS7B reduces GO3P to HXDG3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75973", "species_29364" ], "products": [ "species_29366", "species_390422" ], "modifiers": [ [ "species_10312120", "catalyst" ] ], "additional_components": [ "ENSXETT00000013330" ] }, "reaction_10334716": { "compartment": "compartment_12045", "id": "reaction_10334716", "reactome": "R-XTR-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200993", "species_30209" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10331494", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10334713": { "compartment": "compartment_12045", "id": "reaction_10334713", "reactome": "R-XTR-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_8848499", "species_76194" ], "modifiers": [ [ "species_10331494", "catalyst" ] ], "additional_components": [ "ENSXETG00000025317" ] }, "reaction_10326149": { "compartment": "compartment_70101", "id": "reaction_10326149", "reactome": "R-XTR-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_2162081", "species_73473" ], "modifiers": [ [ "species_10311790", "catalyst" ] ], "additional_components": [ "A0A6I8RYK1", "ENSXETG00000032351", "species_29426" ] }, "reaction_10326146": { "compartment": "compartment_70101", "id": "reaction_10326146", "reactome": "R-XTR-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10312008", "catalyst" ] ], "additional_components": [ "species_109496", "Q5EBF1", "ENSXETG00000009475" ] }, "reaction_10324293": { "compartment": "compartment_876", "id": "reaction_10324293", "reactome": "R-XTR-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10324290", "catalyst" ] ], "additional_components": [ "species_74112", "A0A6I8QLK5", "ENSXETG00000030514", "A0A6I8SLR0", "ENSXETG00000003578", "A0A6I8QCS0", "ENSXETG00000007772" ] }, "reaction_10324274": { "compartment": "compartment_70101", "id": "reaction_10324274", "reactome": "R-XTR-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10324015", "catalyst" ] ], "additional_components": [ "ENSXETG00000009899" ] }, "reaction_10324265": { "compartment": "compartment_70101", "id": "reaction_10324265", "reactome": "R-XTR-1855202", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629746" ], "products": [ "species_29372", "species_1629731" ], "modifiers": [ [ "species_10324057", "catalyst" ] ], "additional_components": [ "ENSXETG00000019407" ] }, "reaction_10324246": { "compartment": "compartment_70101", "id": "reaction_10324246", "reactome": "R-XTR-1855180", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994123" ], "products": [ "species_29372", "species_1629769" ], "modifiers": [ [ "species_10324057", "catalyst" ] ], "additional_components": [ "ENSXETG00000019407" ] }, "reaction_10324243": { "compartment": "compartment_70101", "id": "reaction_10324243", "reactome": "R-XTR-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10324015", "catalyst" ] ], "additional_components": [ "ENSXETG00000009899" ] }, "reaction_10324268": { "compartment": "compartment_7660", "id": "reaction_10324268", "reactome": "R-XTR-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10324230", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324249": { "compartment": "compartment_7660", "id": "reaction_10324249", "reactome": "R-XTR-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10324230", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324233": { "compartment": "compartment_7660", "id": "reaction_10324233", "reactome": "R-XTR-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10324230", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324299": { "compartment": "compartment_7660", "id": "reaction_10324299", "reactome": "R-XTR-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023940" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10324230", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10324305": { "compartment": "compartment_7660", "id": "reaction_10324305", "reactome": "R-XTR-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023922" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10324230", "catalyst" ] ], "additional_components": [ "ENSXETT00000020549" ] }, "reaction_10323209": { "compartment": "compartment_876", "id": "reaction_10323209", "reactome": "R-XTR-1475017", "name": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10322211", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8QID1", "ENSXETG00000034545" ] }, "reaction_10323220": { "compartment": "compartment_876", "id": "reaction_10323220", "reactome": "R-XTR-1475025", "name": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10322211", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8QID1", "ENSXETG00000034545" ] }, "reaction_10323222": { "compartment": "compartment_70101", "id": "reaction_10323222", "reactome": "R-XTR-1475026", "name": "Carbonic anhydrase hydrates carbon dioxide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113528" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10323215", "catalyst" ] ], "additional_components": [ "Q28CD7", "ENSXETT00000069496", "species_29426" ] }, "reaction_10323218": { "compartment": "compartment_70101", "id": "reaction_10323218", "reactome": "R-XTR-1475022", "name": "Carbonic anhydrase dehydrates bicarbonate (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_29356", "species_113528" ], "modifiers": [ [ "species_10323215", "catalyst" ] ], "additional_components": [ "Q28CD7", "ENSXETT00000069496", "species_29426" ] }, "reaction_10331322": { "compartment": "compartment_17963", "id": "reaction_10331322", "reactome": "R-XTR-5693925", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693930", "species_205683" ], "products": [ "species_5693933", "species_205689" ], "modifiers": [ [ "species_10331319", "catalyst" ] ], "additional_components": [ "ENSXETG00000032714" ] }, "reaction_10321826": { "compartment": "compartment_20699", "id": "reaction_10321826", "reactome": "R-XTR-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10321823", "catalyst" ] ], "additional_components": [ "ENSXETT00000016641" ] }, "reaction_10318217": { "compartment": "compartment_1462052", "id": "reaction_10318217", "reactome": "R-XTR-437085", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10318214", "catalyst" ] ], "additional_components": [ "ENSXETG00000000472" ] }, "reaction_10318231": { "compartment": "compartment_20699", "id": "reaction_10318231", "reactome": "R-XTR-437139", "name": "ZnT6 transports zinc into the golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216667" ], "modifiers": [ [ "species_10318228", "catalyst" ] ], "additional_components": [ "ENSXETT00000054089" ] }, "reaction_10318224": { "compartment": "compartment_20699", "id": "reaction_10318224", "reactome": "R-XTR-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10318221", "catalyst" ] ], "additional_components": [ "ENSXETG00000027945" ] }, "reaction_10318210": { "compartment": "compartment_876", "id": "reaction_10318210", "reactome": "R-XTR-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10318207", "catalyst" ] ], "additional_components": [ "ENSXETG00000034450" ] }, "reaction_10336888": { "compartment": "compartment_70101", "id": "reaction_10336888", "reactome": "R-XTR-8952716", "name": "SLC38A9 binds Ragulator:Rag dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330239", "species_10330253" ], "products": [ "species_10330255" ], "modifiers": [], "additional_components": [ "ENSXETG00000028090", "F6W400", "ENSXETT00000041436", "species_29438", "B4F6Y3", "ENSXETG00000026765", "Q6DF40", "ENSXETG00000020403", "A9UL91", "ENSXETT00000103950", "Q6P2W7", "ENSXETG00000024963", "F6W400", "ENSXETT00000041436", "species_29438", "B4F6Y3", "ENSXETG00000026765", "Q6DF40", "ENSXETG00000020403", "A9UL91", "ENSXETT00000103950", "Q6P2W7", "ENSXETG00000024963", "A0A6I8RIW4", "ENSXETG00000028090" ] }, "reaction_10336891": { "compartment": "compartment_70101", "id": "reaction_10336891", "reactome": "R-XTR-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10330255", "catalyst" ] ], "additional_components": [ "F6W400", "ENSXETT00000041436", "species_29438", "B4F6Y3", "ENSXETG00000026765", "Q6DF40", "ENSXETG00000020403", "A9UL91", "ENSXETT00000103950", "Q6P2W7", "ENSXETG00000024963", "A0A6I8RIW4", "ENSXETG00000028090" ] }, "reaction_10338102": { "compartment": "compartment_70101", "id": "reaction_10338102", "reactome": "R-XTR-9679044", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338098", "species_9678687" ], "products": [ "species_10338100" ], "modifiers": [], "additional_components": [ "ENSXETT00000003463", "F7BKJ1", "ENSXETT00000003463" ] }, "reaction_10338253": { "compartment": "compartment_984", "id": "reaction_10338253", "reactome": "R-XTR-9707586", "name": "FeHM oxidises LDL,HDL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338243", "species_917955" ], "products": [ "species_917877", "species_10338251" ], "modifiers": [], "additional_components": [ "species_171126", "A0A6I8RKY6", "ENSXETG00000026768", "species_163579", "species_171142", "species_216762", "species_171126", "A0A6I8RKY6", "ENSXETG00000026768", "species_163579", "species_2186967", "species_171142", "species_216762" ] }, "reaction_10338255": { "compartment": "compartment_7660", "id": "reaction_10338255", "reactome": "R-XTR-9707690", "name": "BACH1 binds MAFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321780", "species_10338235" ], "products": [ "species_10338237" ], "modifiers": [], "additional_components": [ "ENSXETT00000041786", "ENSXETT00000017505", "F6Y302", "ENSXETT00000017505", "F7A9R6", "ENSXETT00000041786" ] }, "reaction_10338231": { "compartment": "compartment_984", "id": "reaction_10338231", "reactome": "R-XTR-9707516", "name": "FeHM dissociates from MetHb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326232" ], "products": [ "species_917955", "species_10338229" ], "modifiers": [], "additional_components": [ "P07428", "ENSXETT00000002494", "species_917955", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "P07428", "ENSXETT00000002494", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627" ] }, "reaction_10338241": { "compartment": "compartment_7660", "id": "reaction_10338241", "reactome": "R-XTR-9707523", "name": "Hemes bind to BACH1:MAFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707575", "species_10338237" ], "products": [ "species_10321780", "species_10338239" ], "modifiers": [], "additional_components": [ "F6Y302", "ENSXETT00000017505", "F7A9R6", "ENSXETT00000041786", "ENSXETT00000041786", "F6Y302", "ENSXETT00000017505" ] }, "reaction_10338226": { "compartment": "compartment_984", "id": "reaction_10338226", "reactome": "R-XTR-9707504", "name": "H2O2 oxidises ferrohemoglobin to MetHb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_10338222" ], "products": [ "species_9707624", "species_9707647", "species_10326232" ], "modifiers": [ [ "species_10338224", "inhibitor" ] ], "additional_components": [ "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494", "P07428", "ENSXETT00000002494", "species_917955", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_9709335", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494" ] }, "reaction_10327581": { "compartment": "compartment_70101", "id": "reaction_10327581", "reactome": "R-XTR-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29368", "species_29408" ], "modifiers": [ [ "species_10327578", "catalyst" ] ], "additional_components": [ "species_29426", "species_209799", "Q0IIW3", "ENSXETT00000015994" ] }, "reaction_10331455": { "compartment": "compartment_5460", "id": "reaction_10331455", "reactome": "R-XTR-5696197", "name": "NUDT2 hydrolyses GP4G to GTP, GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696199", "species_113521" ], "products": [ "species_5696194", "species_113573" ], "modifiers": [ [ "species_10331452", "catalyst" ] ], "additional_components": [ "ENSXETT00000004614" ] }, "reaction_10327705": { "compartment": "compartment_70616", "id": "reaction_10327705", "reactome": "R-XTR-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_10313148" ], "products": [ "species_189461", "species_10313146" ], "modifiers": [], "additional_components": [ "Q640U4", "ENSXETT00000018532", "Q6PBF4", "ENSXETT00000049267", "CHEBI:38574", "Q640U4", "ENSXETT00000018532", "Q6PBF4", "ENSXETT00000049267", "CHEBI:38573" ] }, "reaction_10328075": { "compartment": "compartment_5460", "id": "reaction_10328075", "reactome": "R-XTR-3697894", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327691", "species_3697881" ], "products": [ "species_3697842", "species_10327694", "species_113521" ], "modifiers": [ [ "species_10327698", "catalyst" ] ], "additional_components": [ "ENSXETT00000089705", "ENSXETT00000089705", "ENSXETT00000013225" ] }, "reaction_10328149": { "compartment": "compartment_17927", "id": "reaction_10328149", "reactome": "R-XTR-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10328146", "catalyst" ] ], "additional_components": [ "species_209799", "Q0IIW3", "ENSXETT00000015994", "species_29426" ] }, "reaction_10327701": { "compartment": "compartment_5460", "id": "reaction_10327701", "reactome": "R-XTR-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327691", "species_1614617" ], "products": [ "species_10327694", "species_113521" ], "modifiers": [ [ "species_10327698", "catalyst" ] ], "additional_components": [ "ENSXETT00000089705", "ENSXETT00000089705", "ENSXETT00000013225" ] }, "reaction_10327715": { "compartment": "compartment_984", "id": "reaction_10327715", "reactome": "R-XTR-3341397", "name": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_1247892" ], "products": [ "species_109276", "species_3341331" ], "modifiers": [ [ "species_10327712", "catalyst" ] ], "additional_components": [ "Q6P8G5", "ENSXETT00000098364" ] }, "reaction_10333618": { "compartment": "compartment_984", "id": "reaction_10333618", "reactome": "R-XTR-6799695", "name": "GPX5,6 reduce H2O2 to H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_1247892" ], "products": [ "species_109276", "species_3341331" ], "modifiers": [ [ "species_10333613", "catalyst" ] ], "additional_components": [ "ENSXETT00000098364" ] }, "reaction_10338265": { "compartment": "compartment_984", "id": "reaction_10338265", "reactome": "R-XTR-9709317", "name": "CO binds to free ferrohemoglobin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338222", "species_9709335" ], "products": [ "species_10338224" ], "modifiers": [], "additional_components": [ "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494", "species_9709335", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494" ] }, "reaction_10338267": { "compartment": "compartment_984", "id": "reaction_10338267", "reactome": "R-XTR-9709360", "name": "H2O2 reduces MetHb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_10326232" ], "products": [ "species_109276", "species_10338222", "species_352327" ], "modifiers": [], "additional_components": [ "P07428", "ENSXETT00000002494", "species_917955", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494" ] }, "reaction_10338261": { "compartment": "compartment_70101", "id": "reaction_10338261", "reactome": "R-XTR-9708466", "name": "BACH1 translocates from the nucleoplasm to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338235" ], "products": [ "species_10338259" ], "modifiers": [ [ "species_3785707", "catalyst" ] ], "additional_components": [ "ENSXETT00000017505", "ENSXETT00000017505" ] }, "reaction_10321885": { "compartment": "compartment_70101", "id": "reaction_10321885", "reactome": "R-XTR-1234161", "name": "HIF-alpha translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321881" ], "products": [ "species_10321883" ], "modifiers": [], "additional_components": [ "ENSXETG00000026167", "ENSXETG00000026167" ] }, "reaction_10328289": { "compartment": "compartment_7660", "id": "reaction_10328289", "reactome": "R-XTR-3857336", "name": "CEBPB homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328281" ], "products": [ "species_10328283" ], "modifiers": [], "additional_components": [ "ENSXETT00000085676", "Q3SYP1", "ENSXETT00000085676" ] }, "reaction_10327348": { "compartment": "compartment_7660", "id": "reaction_10327348", "reactome": "R-XTR-3240295", "name": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10327345" ], "products": [ "species_77502", "species_10327343" ], "modifiers": [ [ "species_10316473", "catalyst" ] ], "additional_components": [ "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146" ] }, "reaction_10327310": { "compartment": "compartment_7660", "id": "reaction_10327310", "reactome": "R-XTR-3209159", "name": "Phosphorylated ERF translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327306" ], "products": [ "species_10327308" ], "modifiers": [], "additional_components": [ "ENSXETG00000012067", "ENSXETG00000012067" ] }, "reaction_10312580": { "compartment": "compartment_876", "id": "reaction_10312580", "reactome": "R-XTR-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10312577", "catalyst" ] ], "additional_components": [ "L7N333", "ENSXETT00000019255", "F6WUY6", "ENSXETT00000027105", "species_109496" ] }, "reaction_10312589": { "compartment": "compartment_70101", "id": "reaction_10312589", "reactome": "R-XTR-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10312586", "catalyst" ] ], "additional_components": [ "F6YP15", "ENSXETT00000040456" ] }, "reaction_10312591": { "compartment": "compartment_70101", "id": "reaction_10312591", "reactome": "R-XTR-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312586" ], "products": [ "species_10312586" ], "modifiers": [], "additional_components": [ "F6YP15", "ENSXETT00000040456", "F6YP15", "ENSXETT00000040456" ] }, "reaction_10335005": { "compartment": "compartment_17963", "id": "reaction_10335005", "reactome": "R-XTR-8851619", "name": "GALNT3 transfers GalNAc to FGF23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10335000" ], "products": [ "species_10335002", "species_205687" ], "modifiers": [ [ "species_10320310", "catalyst" ] ], "additional_components": [ "ENSXETG00000026353", "ENSXETG00000026353", "ENSXETT00000045011" ] }, "reaction_10335007": { "compartment": "compartment_17963", "id": "reaction_10335007", "reactome": "R-XTR-8851632", "name": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335002" ], "products": [ "species_10314114" ], "modifiers": [], "additional_components": [ "ENSXETG00000026353", "ENSXETG00000026353" ] }, "reaction_10320127": { "compartment": "compartment_876", "id": "reaction_10320127", "reactome": "R-XTR-877187", "name": "P2X7 mediates loss of intracellular K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10320124", "catalyst" ] ], "additional_components": [ "A0A6I8S619", "ENSXETG00000041261", "species_113593" ] }, "reaction_10320159": { "compartment": "compartment_70101", "id": "reaction_10320159", "reactome": "R-XTR-879221", "name": "PSTPIP1 binds Pyrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320155", "species_10320139" ], "products": [ "species_10320157" ], "modifiers": [], "additional_components": [ "A0A6I8QK31", "ENSXETG00000033202", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8QK31", "ENSXETG00000033202", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292" ] }, "reaction_10320120": { "compartment": "compartment_70101", "id": "reaction_10320120", "reactome": "R-XTR-844447", "name": "NLRP1 senses MDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_708341", "species_10320110" ], "products": [ "species_10320112" ], "modifiers": [], "additional_components": [ "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "species_708341" ] }, "reaction_10320149": { "compartment": "compartment_70101", "id": "reaction_10320149", "reactome": "R-XTR-879201", "name": "Bcl-2 and Bcl-XL bind NLRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320145", "species_10320110" ], "products": [ "species_10320147" ], "modifiers": [], "additional_components": [ "A0A6I8QYM7", "ENSXETG00000035771", "F6XC18", "ENSXETT00000050759", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "A0A6I8QYM7", "ENSXETG00000035771", "F6XC18", "ENSXETT00000050759" ] }, "reaction_10320118": { "compartment": "compartment_70101", "id": "reaction_10320118", "reactome": "R-XTR-844438", "name": "NLRP1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320114" ], "products": [ "species_10320116" ], "modifiers": [], "additional_components": [ "species_113593", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "species_708341", "species_113593", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "species_708341" ] }, "reaction_10320161": { "compartment": "compartment_70101", "id": "reaction_10320161", "reactome": "R-XTR-879222", "name": "MDP:NLRP1 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320112", "species_113592" ], "products": [ "species_10320114" ], "modifiers": [], "additional_components": [ "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "species_708341", "species_113593", "A0A6I8QL30", "ENSXETG00000038851", "A0A6I8Q7C5", "ENSXETG00000038851", "A0A6I8PU00", "ENSXETG00000038253", "species_708341" ] }, "reaction_10320168": { "compartment": "compartment_876", "id": "reaction_10320168", "reactome": "R-XTR-879585", "name": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879559" ], "products": [ "species_879544" ], "modifiers": [ [ "species_10320165", "catalyst" ] ], "additional_components": [ "CHEBI:16196", "CHEBI:16196", "ENSXETG00000037018" ] }, "reaction_10322403": { "compartment": "compartment_876", "id": "reaction_10322403", "reactome": "R-XTR-1299304", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10322400", "catalyst" ] ], "additional_components": [ "F7AEN8", "ENSXETT00000009094" ] }, "reaction_10322456": { "compartment": "compartment_984", "id": "reaction_10322456", "reactome": "R-XTR-1362465", "name": "GHBP binds GHR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320900", "species_10320910" ], "products": [ "species_10320912" ], "modifiers": [], "additional_components": [ "ENSXETG00000037965", "ENSXETG00000037965", "A0A6I8PXI3", "ENSXETG00000037965" ] }, "reaction_10320917": { "compartment": "compartment_70101", "id": "reaction_10320917", "reactome": "R-XTR-982792", "name": "Growth hormone receptor binds JAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320900", "species_10320904" ], "products": [ "species_10320906" ], "modifiers": [], "additional_components": [ "ENSXETG00000037965", "ENSXETG00000000586", "A0A6I8QZL9", "ENSXETG00000000586", "A0A6I8PXI3", "ENSXETG00000037965" ] }, "reaction_10320914": { "compartment": "compartment_876", "id": "reaction_10320914", "reactome": "R-XTR-982775", "name": "Growth hormone receptor dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320906" ], "products": [ "species_10320908" ], "modifiers": [ [ "species_10320912", "inhibitor" ] ], "additional_components": [ "A0A6I8QZL9", "ENSXETG00000000586", "A0A6I8PXI3", "ENSXETG00000037965", "A0A6I8QZL9", "ENSXETG00000000586", "A0A6I8PXI3", "ENSXETG00000037965", "A0A6I8PXI3", "ENSXETG00000037965" ] }, "reaction_10330559": { "compartment": "compartment_876", "id": "reaction_10330559", "reactome": "R-XTR-5676592", "name": "2xRANK binds RANKL,sRANKL trimer:RANK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330551", "species_10330553" ], "products": [ "species_10330557" ], "modifiers": [], "additional_components": [ "ENSXETT00000001109", "F7DPT4", "ENSXETT00000001109", "F6WJ69", "ENSXETT00000005335", "A0A6I8PXA6", "ENSXETG00000030595", "F7DPT4", "ENSXETT00000001109", "F6WJ69", "ENSXETT00000005335", "A0A6I8PXA6", "ENSXETG00000030595" ] }, "reaction_10330555": { "compartment": "compartment_876", "id": "reaction_10330555", "reactome": "R-XTR-5676589", "name": "RANKL,sRANKL trimer binds RANK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330455", "species_10330551" ], "products": [ "species_10330553" ], "modifiers": [], "additional_components": [ "F6WJ69", "ENSXETT00000005335", "A0A6I8PXA6", "ENSXETG00000030595", "ENSXETT00000001109", "F7DPT4", "ENSXETT00000001109", "F6WJ69", "ENSXETT00000005335", "A0A6I8PXA6", "ENSXETG00000030595" ] }, "reaction_10330429": { "compartment": "compartment_876", "id": "reaction_10330429", "reactome": "R-XTR-5669012", "name": "EDA binds EDAR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330421", "species_10330425" ], "products": [ "species_10330427" ], "modifiers": [], "additional_components": [ "ENSXETG00000039649", "ENSXETT00000004819", "Q6DF68", "ENSXETT00000004819", "A0A6I8RPF6", "ENSXETG00000039649" ] }, "reaction_10330437": { "compartment": "compartment_876", "id": "reaction_10330437", "reactome": "R-XTR-5669013", "name": "EDA-3 binds EDA2R", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330433", "species_10330421" ], "products": [ "species_10330435" ], "modifiers": [], "additional_components": [ "ENSXETT00000025196", "ENSXETG00000039649", "A0A6I8RPF6", "ENSXETG00000039649", "F7D7R4", "ENSXETT00000025196" ] }, "reaction_10330465": { "compartment": "compartment_876", "id": "reaction_10330465", "reactome": "R-XTR-5669097", "name": "LTA trimer binds TNFRSF1A,1B,14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330459", "species_10330461" ], "products": [ "species_10330463" ], "modifiers": [], "additional_components": [ "A0A6I8PXQ3", "ENSXETG00000035588", "A0A6I8PW21", "ENSXETG00000032118", "A0A6I8PXQ3", "ENSXETG00000035588", "A0A6I8PW21", "ENSXETG00000032118" ] }, "reaction_10332225": { "compartment": "compartment_984", "id": "reaction_10332225", "reactome": "R-XTR-6783670", "name": "CRLF1 binds CLCF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331527", "species_10331531" ], "products": [ "species_10331533" ], "modifiers": [], "additional_components": [ "F6UWV2", "ENSXETT00000045077", "A0A6I8SGV0", "ENSXETG00000036989", "ENSXETG00000023198", "A0A6I8PWA6", "ENSXETG00000023198", "F6UWV2", "ENSXETT00000045077", "A0A6I8SGV0", "ENSXETG00000036989" ] }, "reaction_10337128": { "compartment": "compartment_70101", "id": "reaction_10337128", "reactome": "R-XTR-9008684", "name": "TBK1 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10320676" ], "products": [ "species_10337126", "species_29370" ], "modifiers": [], "additional_components": [ "ENSXETG00000007322", "ENSXETG00000007322" ] }, "reaction_10327030": { "compartment": "compartment_70101", "id": "reaction_10327030", "reactome": "R-XTR-2730894", "name": "NFKB1:RELA translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313343" ], "products": [ "species_10313349" ], "modifiers": [], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173" ] }, "reaction_10332406": { "compartment": "compartment_17957", "id": "reaction_10332406", "reactome": "R-XTR-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10332404" ], "modifiers": [], "additional_components": [ "ENSXETG00000005359" ] }, "reaction_10332274": { "compartment": "compartment_70101", "id": "reaction_10332274", "reactome": "R-XTR-6785898", "name": "IL4R binds JAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320904", "species_10332270" ], "products": [ "species_10332272" ], "modifiers": [], "additional_components": [ "ENSXETG00000000586", "ENSXETG00000040733", "A0A6I8S2C9", "ENSXETG00000040733", "A0A6I8QZL9", "ENSXETG00000000586" ] }, "reaction_10318525": { "compartment": "compartment_984", "id": "reaction_10318525", "reactome": "R-XTR-448632", "name": "IL34 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318521" ], "products": [ "species_10318523" ], "modifiers": [], "additional_components": [ "ENSXETG00000038235", "A0A6I8QP85", "ENSXETG00000038235" ] }, "reaction_10318556": { "compartment": "compartment_984", "id": "reaction_10318556", "reactome": "R-XTR-449087", "name": "CD4 binds Interleukin-16", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318546", "species_10318552" ], "products": [ "species_10318554" ], "modifiers": [], "additional_components": [ "ENSXETG00000031478", "ENSXETT00000017485", "F7BD23", "ENSXETT00000017485", "A0A6I8SKD0", "ENSXETG00000031478" ] }, "reaction_10337036": { "compartment": "compartment_984", "id": "reaction_10337036", "reactome": "R-XTR-8981657", "name": "IL34 dimer binds PTPRZ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318523", "species_10337032" ], "products": [ "species_10337034" ], "modifiers": [], "additional_components": [ "A0A6I8QP85", "ENSXETG00000038235", "ENSXETG00000022735", "A0A6I8QZW2", "ENSXETG00000022735", "A0A6I8QP85", "ENSXETG00000038235" ] }, "reaction_10318548": { "compartment": "compartment_984", "id": "reaction_10318548", "reactome": "R-XTR-449077", "name": "Interleukin-16 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318541" ], "products": [ "species_10318546" ], "modifiers": [], "additional_components": [ "ENSXETG00000031478", "ENSXETG00000031478" ] }, "reaction_10318544": { "compartment": "compartment_70101", "id": "reaction_10318544", "reactome": "R-XTR-449073", "name": "Caspase-3 cleaves pro-interleukin-16", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318537" ], "products": [ "species_10318539", "species_10318541" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000031478", "ENSXETG00000031478", "ENSXETG00000031478", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10324152": { "compartment": "compartment_70101", "id": "reaction_10324152", "reactome": "R-XTR-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324128", "species_10324148" ], "products": [ "species_10324146", "species_10324150" ], "modifiers": [], "additional_components": [ "A0A6I8S9G6", "ENSXETG00000036095", "A0A6I8QSS2", "ENSXETG00000027885", "A0A6I8SXK0", "ENSXETG00000017287", "Q28ET8", "ENSXETG00000015908", "B7ZTW1", "ENSXETT00000030049", "F6V5S1", "ENSXETT00000039793", "A0A6I8SXK0", "ENSXETG00000017287", "Q28ET8", "ENSXETG00000015908", "B7ZTW1", "ENSXETT00000030049", "F6V5S1", "ENSXETT00000039793", "A0A6I8S9G6", "ENSXETG00000036095", "A0A6I8QSS2", "ENSXETG00000027885" ] }, "reaction_10320256": { "compartment": "compartment_70101", "id": "reaction_10320256", "reactome": "R-XTR-912685", "name": "UBP43 binds IFNAR2 and prevents JAK1 interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320248", "species_10320252" ], "products": [ "species_10320254" ], "modifiers": [], "additional_components": [ "ENSXETG00000038384", "ENSXETG00000034297", "A0A6I8R9K6", "ENSXETG00000034297", "A0A6I8QPM9", "ENSXETG00000038384" ] }, "reaction_10338086": { "compartment": "compartment_70101", "id": "reaction_10338086", "reactome": "R-XTR-9678561", "name": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338082", "species_9678984" ], "products": [ "species_10338084" ], "modifiers": [], "additional_components": [ "A0A6I8QPM9", "ENSXETG00000038384", "A0A6I8PL76", "ENSXETG00000030084", "A0A6I8QZL9", "ENSXETG00000000586", "A0A6I8QPM9", "ENSXETG00000038384", "A0A6I8PL76", "ENSXETG00000030084", "A0A6I8QZL9", "ENSXETG00000000586" ] }, "reaction_10315732": { "compartment": "compartment_70101", "id": "reaction_10315732", "reactome": "R-XTR-202407", "name": "PLC-gamma1 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10315729", "catalyst" ] ], "additional_components": [ "ENSXETG00000003578" ] }, "reaction_10317382": { "compartment": "compartment_70101", "id": "reaction_10317382", "reactome": "R-XTR-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317378", "species_10312717" ], "products": [ "species_10317376", "species_10317380" ], "modifiers": [], "additional_components": [ "A0A6I8T271", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10317356": { "compartment": "compartment_876", "id": "reaction_10317356", "reactome": "R-XTR-389523", "name": "BTLA interacts with HVEM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317348", "species_10317352" ], "products": [ "species_10317354" ], "modifiers": [], "additional_components": [ "ENSXETG00000040606", "ENSXETG00000035588", "A0A6I8PXQ3", "ENSXETG00000035588", "A0A6I8QYL7", "ENSXETG00000040606" ] }, "reaction_10317402": { "compartment": "compartment_70101", "id": "reaction_10317402", "reactome": "R-XTR-389919", "name": "Grb2 binds pBTLA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317398", "species_10312043" ], "products": [ "species_10317400" ], "modifiers": [], "additional_components": [ "A0A6I8PXQ3", "ENSXETG00000035588", "A0A6I8QYL7", "ENSXETG00000040606", "ENSXETT00000027387", "Q66II3", "ENSXETT00000027387", "A0A6I8PXQ3", "ENSXETG00000035588", "A0A6I8QYL7", "ENSXETG00000040606" ] }, "reaction_10338149": { "compartment": "compartment_70101", "id": "reaction_10338149", "reactome": "R-XTR-9690461", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338098", "species_9678991" ], "products": [ "species_10338147" ], "modifiers": [], "additional_components": [ "ENSXETT00000003463", "F7BKJ1", "ENSXETT00000003463" ] }, "reaction_10321852": { "compartment": "compartment_70101", "id": "reaction_10321852", "reactome": "R-XTR-1168633", "name": "NF-kappaB translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321840" ], "products": [ "species_10321850" ], "modifiers": [], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SJP9", "ENSXETG00000002209", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SJP9", "ENSXETG00000002209" ] }, "reaction_10321828": { "compartment": "compartment_70101", "id": "reaction_10321828", "reactome": "R-XTR-1168373", "name": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_10312735", "species_74016" ], "products": [ "species_10312741" ], "modifiers": [], "additional_components": [ "ENSXETG00000017294", "species_114519", "species_33625", "species_74112", "A8KBH6", "ENSXETG00000017294" ] }, "reaction_10316771": { "compartment": "compartment_70101", "id": "reaction_10316771", "reactome": "R-XTR-354173", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10316762" ], "products": [ "species_29420", "species_10316760" ], "modifiers": [ [ "species_10316768", "catalyst" ] ], "additional_components": [ "Q640R7", "ENSXETT00000104159", "species_29420", "Q640R7", "ENSXETT00000104159", "species_29438", "species_74112", "A0A6I8S7H2", "ENSXETG00000040253", "species_114519" ] }, "reaction_10317651": { "compartment": "compartment_70101", "id": "reaction_10317651", "reactome": "R-XTR-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316760" ], "products": [ "species_111294", "species_10316762" ], "modifiers": [ [ "species_10317648", "catalyst" ] ], "additional_components": [ "Q640R7", "ENSXETT00000104159", "species_29438", "Q640R7", "ENSXETT00000104159", "species_29420", "ENSXETG00000034215" ] }, "reaction_10335085": { "compartment": "compartment_876", "id": "reaction_10335085", "reactome": "R-XTR-8852010", "name": "BTNL2 binds activated T cells surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851965", "species_10335081" ], "products": [ "species_10335083" ], "modifiers": [], "additional_components": [ "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889" ] }, "reaction_10334889": { "compartment": "compartment_876", "id": "reaction_10334889", "reactome": "R-XTR-8851018", "name": "BTN2A1 binds DC-SIGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334885", "species_10329899" ], "products": [ "species_10334887" ], "modifiers": [], "additional_components": [ "A0A6I8RCC8", "ENSXETT00000021506", "F7AL17", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8SQD0", "ENSXETG00000030055", "K9J7V7", "ENSXETT00000021506", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "A0A6I8RCC8", "ENSXETT00000021506", "F7AL17", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8SQD0", "ENSXETG00000030055", "K9J7V7", "ENSXETT00000021506" ] }, "reaction_10336232": { "compartment": "compartment_876", "id": "reaction_10336232", "reactome": "R-XTR-8938431", "name": "BTN3A1 and BTN1A1 binds periplakin (PPL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336224", "species_10336228" ], "products": [ "species_10336230" ], "modifiers": [], "additional_components": [ "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506", "ENSXETG00000009137", "A0A6I8RD21", "ENSXETG00000009137", "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506" ] }, "reaction_10334949": { "compartment": "compartment_876", "id": "reaction_10334949", "reactome": "R-XTR-8851038", "name": "BTN3A1 binds prenylated phosphoantigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851032", "species_10334945" ], "products": [ "species_10334947" ], "modifiers": [], "additional_components": [ "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055" ] }, "reaction_10335063": { "compartment": "compartment_876", "id": "reaction_10335063", "reactome": "R-XTR-8851988", "name": "BTN2A2 binds T cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335059", "species_8851965" ], "products": [ "species_10335061" ], "modifiers": [], "additional_components": [ "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506" ] }, "reaction_10335041": { "compartment": "compartment_876", "id": "reaction_10335041", "reactome": "R-XTR-8851979", "name": "BTNL9 binds immune cell surfaces", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851998", "species_10335037" ], "products": [ "species_10335039" ], "modifiers": [], "additional_components": [ "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8QRU2", "ENSXETG00000037889", "F7AL17", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8T2C4", "ENSXETG00000006889", "A0A6I8RCC8", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055" ] }, "reaction_10335107": { "compartment": "compartment_876", "id": "reaction_10335107", "reactome": "R-XTR-8852013", "name": "BTNL8 binds resting T cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851976", "species_10335103" ], "products": [ "species_10335105" ], "modifiers": [], "additional_components": [ "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506", "K9J7V7", "ENSXETT00000021506", "A0A6I8PY83", "ENSXETT00000021506", "A0A6I8T2C4", "ENSXETG00000006889", "F7AL17", "ENSXETT00000021506", "A0A6I8SQD0", "ENSXETG00000030055", "A0A6I8SWS4", "ENSXETG00000041242", "A0A6I8QRU2", "ENSXETG00000037889", "A0A6I8RCC8", "ENSXETT00000021506" ] }, "reaction_10326539": { "compartment": "compartment_453088", "id": "reaction_10326539", "reactome": "R-XTR-2213239", "name": "Formation of MHC II alpha beta heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326535", "species_10326509" ], "products": [ "species_10326537" ], "modifiers": [], "additional_components": [ "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8PRA1", "ENSXETG00000034043" ] }, "reaction_10326006": { "compartment": "compartment_161320", "id": "reaction_10326006", "reactome": "R-XTR-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10326003", "catalyst" ] ], "additional_components": [ "A0A6I8RUR5", "ENSXETG00000035955", "A0A6I8QK05", "ENSXETG00000027581" ] }, "reaction_10335318": { "compartment": "compartment_876", "id": "reaction_10335318", "reactome": "R-XTR-8856157", "name": "LAG3 (CD233) binds MHC II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335314", "species_10335260" ], "products": [ "species_10335316" ], "modifiers": [], "additional_components": [ "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091", "ENSXETG00000004981", "A0A6I8PSX8", "ENSXETG00000004981", "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091" ] }, "reaction_10326627": { "compartment": "compartment_161320", "id": "reaction_10326627", "reactome": "R-XTR-2213244", "name": "Loading of antigenic peptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213226", "species_10326623" ], "products": [ "species_10326625", "species_10326567" ], "modifiers": [], "additional_components": [ "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8PRA1", "ENSXETG00000034043", "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8Q5N0", "ENSXETG00000040091", "A0A6I8PRA1", "ENSXETG00000034043" ] }, "reaction_10321631": { "compartment": "compartment_13945", "id": "reaction_10321631", "reactome": "R-XTR-983421", "name": "Journey of cargo through Golgi complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321513" ], "products": [ "species_10321629" ], "modifiers": [], "additional_components": [ "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "CHEBI:59080", "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "CHEBI:59080" ] }, "reaction_10321747": { "compartment": "compartment_876", "id": "reaction_10321747", "reactome": "R-XTR-983427", "name": "Expression of peptide bound class I MHC on cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321629" ], "products": [ "species_10314568" ], "modifiers": [], "additional_components": [ "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "CHEBI:59080", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246" ] }, "reaction_10322204": { "compartment": "compartment_1222693", "id": "reaction_10322204", "reactome": "R-XTR-1236965", "name": "Export of peptide loaded MHC class I complex to PM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322202" ], "products": [ "species_10314568" ], "modifiers": [], "additional_components": [ "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246" ] }, "reaction_10322086": { "compartment": "compartment_876", "id": "reaction_10322086", "reactome": "R-XTR-1236964", "name": "Translocation of peptide bound MHC class I complex to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322080" ], "products": [ "species_10314568" ], "modifiers": [], "additional_components": [ "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246", "species_1236727", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246" ] }, "reaction_10322082": { "compartment": "compartment_171043", "id": "reaction_10322082", "reactome": "R-XTR-1236943", "name": "Loading of antigen peptide onto MHC class I molecule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236727", "species_10322078" ], "products": [ "species_10322080" ], "modifiers": [], "additional_components": [ "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8PKK9", "ENSXETG00000033246", "species_1236727" ] }, "reaction_10321964": { "compartment": "compartment_24339", "id": "reaction_10321964", "reactome": "R-XTR-1236941", "name": "Internalization of receptor bound antigen into clathrin coted vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321942" ], "products": [ "species_10321962" ], "modifiers": [], "additional_components": [ "species_1236715", "L7N3D8", "ENSXETT00000028489", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "species_1236715", "L7N3D8", "ENSXETT00000028489", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813" ] }, "reaction_10322084": { "compartment": "compartment_24339", "id": "reaction_10322084", "reactome": "R-XTR-1236955", "name": "Movement of clathrin coated vesicles into early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321962" ], "products": [ "species_10321920" ], "modifiers": [], "additional_components": [ "species_1236715", "L7N3D8", "ENSXETT00000028489", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "L7N3D8", "ENSXETT00000028489", "species_1236715" ] }, "reaction_10321922": { "compartment": "compartment_171043", "id": "reaction_10321922", "reactome": "R-XTR-1236940", "name": "Exogenous soluble antigen targeted to more stable early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321920" ], "products": [ "species_1236715", "species_10321918" ], "modifiers": [], "additional_components": [ "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "L7N3D8", "ENSXETT00000028489", "species_1236715", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "L7N3D8", "ENSXETT00000028489" ] }, "reaction_10321357": { "compartment": "compartment_70101", "id": "reaction_10321357", "reactome": "R-XTR-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321345", "species_113592", "species_10321339" ], "products": [ "species_111294", "species_10321352", "species_10321337", "species_76577" ], "modifiers": [ [ "species_10321345", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "Q6GL05", "ENSXETT00000101990", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "Q6GL05", "ENSXETT00000101990", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608" ] }, "reaction_10321359": { "compartment": "compartment_70101", "id": "reaction_10321359", "reactome": "R-XTR-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321281", "species_10321339", "species_983035" ], "products": [ "species_10321341" ], "modifiers": [], "additional_components": [ "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "Q6GL05", "ENSXETT00000101990", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q6GL05", "ENSXETT00000101990", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608" ] }, "reaction_10321354": { "compartment": "compartment_70101", "id": "reaction_10321354", "reactome": "R-XTR-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321352" ], "products": [ "species_10321281", "species_983123" ], "modifiers": [], "additional_components": [ "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608" ] }, "reaction_10321348": { "compartment": "compartment_70101", "id": "reaction_10321348", "reactome": "R-XTR-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10321341" ], "products": [ "species_111294", "species_10321345", "species_10321337", "species_76577" ], "modifiers": [ [ "species_10321281", "catalyst" ] ], "additional_components": [ "Q6GL05", "ENSXETT00000101990", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608", "Q6GL05", "ENSXETT00000101990", "F7DJL8", "ENSXETT00000025117", "F7EP40", "ENSXETT00000016718", "A0A6I8S8J7", "ENSXETG00000008090", "Q6P1V3", "ENSXETT00000046179", "A0A6I8QHG5", "ENSXETG00000039845", "A0A6I8T262", "ENSXETG00000035671", "Q07G42", "ENSXETG00000004580", "B4F6W9", "ENSXETT00000085319", "A0A6I8S237", "ENSXETG00000034411", "K9J7V3", "ENSXETT00000014255", "F7CTL7", "ENSXETT00000018292", "A0A6I8S0I4", "ENSXETG00000035313", "F6Y9J3", "ENSXETT00000073985", "A0A6I8RJ77", "ENSXETG00000036916", "A0A6I8SWC6", "ENSXETG00000031311", "A0A6I8SN42", "ENSXETG00000036844", "F6ZT52", "ENSXETT00000091115", "A0A6I8Q4I3", "ENSXETG00000038110", "F7CA07", "ENSXETT00000042434", "B2GUS9", "ENSXETT00000063698", "Q5XGI3", "ENSXETG00000020331", "A0A6I8R265", "ENSXETG00000030638", "Q5XGG5", "ENSXETT00000027235", "Q0D2D2", "ENSXETT00000037873", "A0A6I8PWZ7", "ENSXETG00000039521", "F6TXL5", "ENSXETT00000035098", "A0A6I8RA00", "ENSXETG00000019608" ] }, "reaction_10334525": { "compartment": "compartment_984", "id": "reaction_10334525", "reactome": "R-XTR-6807585", "name": "BPI binds LPS on the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10313204" ], "products": [ "species_10334523" ], "modifiers": [], "additional_components": [ "ENSXETG00000017331", "A0A6I8REW5", "ENSXETG00000017331", "species_166005" ] }, "reaction_10333951": { "compartment": "compartment_984", "id": "reaction_10333951", "reactome": "R-XTR-6801762", "name": "REG3A oligomerize to form a pore complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333945" ], "products": [ "species_10333949" ], "modifiers": [ [ "species_166005", "inhibitor" ] ], "additional_components": [ "CHEBI:62643", "A0A6I8PQ14", "ENSXETG00000033383", "CHEBI:62643", "A0A6I8PQ14", "ENSXETG00000033383" ] }, "reaction_10321873": { "compartment": "compartment_1222282", "id": "reaction_10321873", "reactome": "R-XTR-1222491", "name": "Lactoferrin scavenges iron ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2101051", "species_1222611", "species_10321869" ], "products": [ "species_10321871" ], "modifiers": [], "additional_components": [ "ENSXETG00000011814", "Q501K5", "ENSXETG00000011814", "species_912516", "species_2101051" ] }, "reaction_10333978": { "compartment": "compartment_984", "id": "reaction_10333978", "reactome": "R-XTR-6803063", "name": "RNASEs bind bacterial LPS, PGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333974", "species_6803074" ], "products": [ "species_10333976" ], "modifiers": [], "additional_components": [ "A0A6I8R6T7", "ENSXETG00000038487", "CHEBI:55478", "species_6789198", "species_166005", "CHEBI:55478", "species_6789198", "species_166005", "A0A6I8R6T7", "ENSXETG00000038487" ] }, "reaction_10334646": { "compartment": "compartment_984", "id": "reaction_10334646", "reactome": "R-XTR-6813659", "name": "ELANE, CTSG or PRTN3 binds bacteria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334642", "species_8879165" ], "products": [ "species_10334644" ], "modifiers": [], "additional_components": [ "A0A6I8RBC3", "ENSXETG00000037351", "Q5HZU5", "ENSXETT00000093455", "A0A6I8QPJ5", "ENSXETG00000039590", "F7EHU5", "ENSXETT00000037000", "A0A6I8RBC3", "ENSXETG00000037351", "Q5HZU5", "ENSXETT00000093455", "A0A6I8QPJ5", "ENSXETG00000039590", "F7EHU5", "ENSXETT00000037000" ] }, "reaction_10334033": { "compartment": "compartment_984", "id": "reaction_10334033", "reactome": "R-XTR-6804527", "name": "INTL1 binds bacterial glycans", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334029", "species_6804535" ], "products": [ "species_10334031" ], "modifiers": [], "additional_components": [ "species_74112", "F7BS21", "ENSXETT00000047100", "CHEBI:42976", "CHEBI:59496", "CHEBI:85986", "CHEBI:42976", "CHEBI:59496", "CHEBI:85986", "species_74112", "F7BS21", "ENSXETT00000047100" ] }, "reaction_10334640": { "compartment": "compartment_984", "id": "reaction_10334640", "reactome": "R-XTR-6813626", "name": "LEAP2 binds bacteria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334636", "species_8931784" ], "products": [ "species_10334638" ], "modifiers": [], "additional_components": [ "ENSXETG00000030080", "CHEBI:62643", "CHEBI:62643", "A0A6I8QY26", "ENSXETG00000030080" ] }, "reaction_10333966": { "compartment": "compartment_984", "id": "reaction_10333966", "reactome": "R-XTR-6801808", "name": "REG3A,REG3G binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333943", "species_6789198" ], "products": [ "species_10333964" ], "modifiers": [], "additional_components": [ "ENSXETG00000033383", "species_6789198", "A0A6I8PQ14", "ENSXETG00000033383" ] }, "reaction_10333960": { "compartment": "compartment_984", "id": "reaction_10333960", "reactome": "R-XTR-6801766", "name": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333953" ], "products": [ "species_10333955", "species_10333943" ], "modifiers": [ [ "species_10333957", "catalyst" ] ], "additional_components": [ "ENSXETG00000033383", "ENSXETG00000033383", "ENSXETG00000033383", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148" ] }, "reaction_10336840": { "compartment": "compartment_984", "id": "reaction_10336840", "reactome": "R-XTR-8948027", "name": "RNASEs bind bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333974", "species_8931784" ], "products": [ "species_10336838" ], "modifiers": [], "additional_components": [ "A0A6I8R6T7", "ENSXETG00000038487", "CHEBI:62643", "CHEBI:62643", "A0A6I8R6T7", "ENSXETG00000038487" ] }, "reaction_10333962": { "compartment": "compartment_984", "id": "reaction_10333962", "reactome": "R-XTR-6801776", "name": "REG3A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333943", "species_8931784" ], "products": [ "species_10333945" ], "modifiers": [], "additional_components": [ "ENSXETG00000033383", "CHEBI:62643", "CHEBI:62643", "A0A6I8PQ14", "ENSXETG00000033383" ] }, "reaction_10335621": { "compartment": "compartment_984", "id": "reaction_10335621", "reactome": "R-XTR-8862320", "name": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10335616" ], "products": [ "species_6788991", "species_6788982" ], "modifiers": [ [ "species_10335616", "catalyst" ] ], "additional_components": [ "A0A6I8RID5", "ENSXETG00000037293", "species_6789198", "species_1236715", "CHEBI:21615", "A0A6I8RID5", "ENSXETG00000037293", "species_6789198" ] }, "reaction_10334628": { "compartment": "compartment_984", "id": "reaction_10334628", "reactome": "R-XTR-6810724", "name": "PI3 binds the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10334624" ], "products": [ "species_10334626" ], "modifiers": [], "additional_components": [ "A0A6I8RZ58", "ENSXETG00000038864", "A0A6I8QJ14", "ENSXETG00000036342", "A0A6I8RZ58", "ENSXETG00000038864", "A0A6I8QJ14", "ENSXETG00000036342", "species_166005" ] }, "reaction_10333638": { "compartment": "compartment_984", "id": "reaction_10333638", "reactome": "R-XTR-6799959", "name": "PGLYRP3,4 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333634", "species_6789198" ], "products": [ "species_10333636" ], "modifiers": [ [ "species_158417", "catalyst" ] ], "additional_components": [ "Q5BKE6", "ENSXETT00000089406", "species_6789198", "Q5BKE6", "ENSXETT00000089406" ] }, "reaction_10332387": { "compartment": "compartment_1222282", "id": "reaction_10332387", "reactome": "R-XTR-6789072", "name": "PGLYRP1 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10332383" ], "products": [ "species_10332385" ], "modifiers": [ [ "species_1562550", "catalyst" ] ], "additional_components": [ "Q5BKE6", "ENSXETT00000089406", "Q5BKE6", "ENSXETT00000089406", "species_6789198" ] }, "reaction_10335618": { "compartment": "compartment_984", "id": "reaction_10335618", "reactome": "R-XTR-8862300", "name": "LYZ binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10332888" ], "products": [ "species_10335616" ], "modifiers": [], "additional_components": [ "ENSXETG00000037293", "A0A6I8RID5", "ENSXETG00000037293", "species_6789198" ] }, "reaction_10327260": { "compartment": "compartment_12045", "id": "reaction_10327260", "reactome": "R-XTR-3134800", "name": "STING dimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324507" ], "products": [ "species_10326753" ], "modifiers": [ [ "species_10327258", "catalyst" ] ], "additional_components": [ "ENSXETG00000016088", "A8E5V9", "ENSXETG00000016088", "ENSXETG00000016088" ] }, "reaction_10327352": { "compartment": "compartment_12045", "id": "reaction_10327352", "reactome": "R-XTR-3244643", "name": "STING binds cyclic GMP-AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326753", "species_3244587" ], "products": [ "species_10327350" ], "modifiers": [], "additional_components": [ "A8E5V9", "ENSXETG00000016088", "species_3244587", "A8E5V9", "ENSXETG00000016088" ] }, "reaction_10326762": { "compartment": "compartment_12045", "id": "reaction_10326762", "reactome": "R-XTR-2396009", "name": "STING binds c-di-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326753", "species_2395973" ], "products": [ "species_10326760" ], "modifiers": [], "additional_components": [ "A8E5V9", "ENSXETG00000016088", "species_2395973", "A8E5V9", "ENSXETG00000016088" ] }, "reaction_10337738": { "compartment": "compartment_70101", "id": "reaction_10337738", "reactome": "R-XTR-9604480", "name": "NFkB complex translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313343" ], "products": [ "species_10313349" ], "modifiers": [], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173" ] }, "reaction_10329903": { "compartment": "compartment_876", "id": "reaction_10329903", "reactome": "R-XTR-5621571", "name": "CD209 binds ICAM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314660", "species_10329899" ], "products": [ "species_10329901" ], "modifiers": [], "additional_components": [ "A0A6I8PWA4", "ENSXETG00000027690", "A0A6I8Q7U5", "ENSXETG00000022064", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "A0A6I8PWA4", "ENSXETG00000027690", "A0A6I8Q7U5", "ENSXETG00000022064" ] }, "reaction_10330318": { "compartment": "compartment_7660", "id": "reaction_10330318", "reactome": "R-XTR-5660980", "name": "p-S276-RELA binds RELB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330314", "species_10329932" ], "products": [ "species_10330316" ], "modifiers": [], "additional_components": [ "ENSXETG00000031521", "ENSXETG00000026173", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8PZ90", "ENSXETG00000031521" ] }, "reaction_10329907": { "compartment": "compartment_876", "id": "reaction_10329907", "reactome": "R-XTR-5621615", "name": "CD209 binds ICAM3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10314666", "species_10329899", "species_74112" ], "products": [ "species_10329905" ], "modifiers": [], "additional_components": [ "A0A6I8Q7U5", "ENSXETG00000022064", "A0A6I8PWA4", "ENSXETG00000027690", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "species_74112", "A0A6I8T2E2", "ENSXETG00000035088", "A0A6I8SP31", "ENSXETG00000012998", "A0A6I8Q7U5", "ENSXETG00000022064", "A0A6I8PWA4", "ENSXETG00000027690" ] }, "reaction_10329834": { "compartment": "compartment_876", "id": "reaction_10329834", "reactome": "R-XTR-5607755", "name": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329832" ], "products": [ "species_10329827" ], "modifiers": [], "additional_components": [ "ENSXETG00000003578", "ENSXETG00000003578" ] }, "reaction_10329830": { "compartment": "compartment_876", "id": "reaction_10329830", "reactome": "R-XTR-5607735", "name": "p-Y753,Y759-PLCG2 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10329827", "catalyst" ] ], "additional_components": [ "ENSXETG00000003578" ] }, "reaction_10335614": { "compartment": "compartment_876", "id": "reaction_10335614", "reactome": "R-XTR-8858500", "name": "CLEC10A binds Tn-MUC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335610", "species_10335598" ], "products": [ "species_10335612" ], "modifiers": [], "additional_components": [ "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522", "ENSXETG00000041320", "A0A6I8Q6M7", "ENSXETG00000041320", "A0A6I8QTA8", "ENSXETG00000018869", "A0A6I8QYJ7", "ENSXETG00000037294", "A0A6I8RWC5", "ENSXETG00000036774", "A0A6I8R3H8", "ENSXETG00000039522" ] }, "reaction_10332377": { "compartment": "compartment_70101", "id": "reaction_10332377", "reactome": "R-XTR-6788999", "name": "HV1-mediated H+ transfer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10332374", "catalyst" ] ], "additional_components": [ "Q5M8L8", "ENSXETT00000045238" ] }, "reaction_10317728": { "compartment": "compartment_70101", "id": "reaction_10317728", "reactome": "R-XTR-418436", "name": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10315942", "catalyst" ] ], "additional_components": [ "ENSXETG00000011979" ] }, "reaction_10313407": { "compartment": "compartment_984", "id": "reaction_10313407", "reactome": "R-XTR-169719", "name": "Secreted CD14 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313202", "species_10313403" ], "products": [ "species_10313200", "species_10313405" ], "modifiers": [], "additional_components": [ "species_166005", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "ENSXETG00000031516", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "A0A6I8PVH6", "ENSXETG00000031516", "species_166005" ] }, "reaction_10313216": { "compartment": "compartment_984", "id": "reaction_10313216", "reactome": "R-XTR-166038", "name": "GPI-bound CD14 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313202", "species_10313212" ], "products": [ "species_10313200", "species_10313214" ], "modifiers": [], "additional_components": [ "species_166005", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "ENSXETG00000031516", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "A0A6I8PVH6", "ENSXETG00000031516", "species_166005" ] }, "reaction_10326889": { "compartment": "compartment_876", "id": "reaction_10326889", "reactome": "R-XTR-2559456", "name": "TIRAP binds PIP2-rich regions in the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326885", "species_179856" ], "products": [ "species_10326887" ], "modifiers": [], "additional_components": [ "ENSXETG00000031764", "species_179856", "A0A6I8QHE1", "ENSXETG00000031764" ] }, "reaction_10313206": { "compartment": "compartment_984", "id": "reaction_10313206", "reactome": "R-XTR-166015", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313200", "species_166005" ], "products": [ "species_10313202" ], "modifiers": [ [ "species_10313204", "inhibitor" ] ], "additional_components": [ "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "species_166005", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "ENSXETG00000017331" ] }, "reaction_10335885": { "compartment": "compartment_984", "id": "reaction_10335885", "reactome": "R-XTR-8869694", "name": "oxPL binds CD14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2186967", "species_10313403" ], "products": [ "species_10335883" ], "modifiers": [], "additional_components": [ "ENSXETG00000031516", "A0A6I8PVH6", "ENSXETG00000031516", "species_2186967" ] }, "reaction_10335881": { "compartment": "compartment_984", "id": "reaction_10335881", "reactome": "R-XTR-8869683", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313200", "species_2186967" ], "products": [ "species_10335879" ], "modifiers": [], "additional_components": [ "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015", "species_2186967", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8QVF2", "ENSXETG00000038104", "A0A6I8QHS4", "ENSXETG00000037015" ] }, "reaction_10313401": { "compartment": "compartment_984", "id": "reaction_10313401", "reactome": "R-XTR-168947", "name": "Ligand binds to TLR10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313395", "species_168948" ], "products": [ "species_10313399" ], "modifiers": [], "additional_components": [ "ENSXETG00000018477", "A0A6I8PMY8", "ENSXETG00000018477" ] }, "reaction_10324331": { "compartment": "compartment_876", "id": "reaction_10324331", "reactome": "R-XTR-1861621", "name": "Cross-linking of FCGRIIA with IgG-coated Ag", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324321", "species_10324327" ], "products": [ "species_10324329" ], "modifiers": [], "additional_components": [ "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8QLS0", "ENSXETG00000041230", "A0A6I8QM25", "ENSXETG00000041230", "A0A6I8PTS9", "ENSXETG00000041230", "A0A6I8RSN1", "ENSXETG00000041230", "A0A6I8PUH7", "ENSXETG00000041230", "A0A6I8S9Z8", "ENSXETG00000041230", "A0A6I8PM56", "ENSXETG00000041230", "A0A6I8RJH0", "ENSXETG00000041230", "A0A6I8PMK7", "ENSXETG00000041230", "A0A6I8RS78", "ENSXETG00000041230", "A0A6I8R4R2", "ENSXETG00000041230", "A0A6I8R767", "ENSXETG00000041230", "A0A6I8RSK9", "ENSXETG00000040383", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212", 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"A0A6I8R2N8", "ENSXETT00000069302", "A0A6I8R7C6", "ENSXETT00000069302", "A0A6I8QNF8", "ENSXETT00000069302", "A0A6I8QSF1", "ENSXETT00000069302", "A0A6I8QE50", "ENSXETT00000069302", "A0A6I8QMZ7", "ENSXETT00000069302", "A0A6I8Q652", "ENSXETT00000069302", "A0A6I8Q664", "ENSXETT00000069302", "A0A6I8Q2X0", "ENSXETT00000069302", "A0A6I8Q318", "ENSXETT00000069302", "A0A6I8Q0S1", "ENSXETT00000069302", "A0A6I8Q2I9", "ENSXETT00000069302", "K9J7P7", "ENSXETT00000007797", "A0A6I8PSU3", "ENSXETG00000039428", "F6S2S6", "ENSXETT00000022997", "A0A6I8Q2V3", "ENSXETG00000039428", "A0A6I8RZZ7", "ENSXETG00000039428", "A0A6I8SEP6", "ENSXETG00000039428", "A0A6I8QNA7", "ENSXETG00000039428", "A0A6I8R2R2", "ENSXETG00000039428", "A0A6I8Q7C1", "ENSXETG00000039428", "A0A6I8QD99", "ENSXETG00000039428", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "A0A6I8SQH9", "ENSXETG00000040813", "A0A6I8RCL0", "ENSXETG00000040813", "A0A6I8SLA7", "ENSXETG00000036911", "A0A6I8QLS0", "ENSXETG00000041230", "A0A6I8QM25", "ENSXETG00000041230", "A0A6I8PTS9", "ENSXETG00000041230", "A0A6I8RSN1", "ENSXETG00000041230", "A0A6I8PUH7", "ENSXETG00000041230", "A0A6I8S9Z8", "ENSXETG00000041230", "A0A6I8PM56", "ENSXETG00000041230", "A0A6I8RJH0", "ENSXETG00000041230", "A0A6I8PMK7", "ENSXETG00000041230", "A0A6I8RS78", "ENSXETG00000041230", "A0A6I8R4R2", "ENSXETG00000041230", "A0A6I8R767", "ENSXETG00000041230", "A0A6I8RSK9", "ENSXETG00000040383", "A0A6I8RFV0", "ENSXETG00000035252", "A0A6I8Q3Z3", "ENSXETG00000039491", "A0A6I8QXJ1", "ENSXETG00000039910", "A0A6I8Q236", "ENSXETG00000039910", "A0A6I8PTQ9", "ENSXETG00000040212", "A0A6I8RGY2", "ENSXETG00000040212", "A0A6I8STT9", "ENSXETG00000040212", "A0A6I8RG22", "ENSXETG00000040212", "A0A6I8SK71", "ENSXETG00000040212", "A0A6I8QZL1", "ENSXETG00000040212", "A0A6I8RUJ4", "ENSXETG00000040212", "A0A6I8QKP4", "ENSXETG00000040212", "A0A6I8RNX1", "ENSXETG00000040212", "A0A6I8SYV6", "ENSXETG00000040212", "A0A6I8PWK1", "ENSXETT00000069302", "A0A6I8PXL5", "ENSXETT00000069302", "A0A5G3K4A2", "ENSXETT00000069302", "F7ATU6", "ENSXETT00000069302", "A0A6I8PNW8", "ENSXETT00000069302", "L7N2W1", "ENSXETT00000013311", "A0A6I8SSF0", "ENSXETT00000069302", "A0A6I8SYX6", "ENSXETT00000069302", "A0A6I8SF25", "ENSXETT00000069302", "A0A6I8SJ82", "ENSXETT00000069302", "A0A6I8SCS2", "ENSXETT00000069302", "A0A6I8SCZ9", "ENSXETT00000069302", "A0A6I8S4K2", "ENSXETT00000069302", "A0A6I8S824", "ENSXETT00000069302", "A0A6I8S1H6", "ENSXETT00000069302", "A0A6I8S3H5", "ENSXETT00000069302", "A0A6I8RTG9", "ENSXETT00000069302", "A0A6I8RYE0", "ENSXETT00000069302", "A0A6I8RLS5", "ENSXETT00000069302", "A0A6I8RQ73", "ENSXETT00000069302", "A0A6I8RDF6", "ENSXETT00000069302", "A0A6I8RF32", "ENSXETT00000069302", "A0A6I8R2N8", "ENSXETT00000069302", "A0A6I8R7C6", "ENSXETT00000069302", "A0A6I8QNF8", "ENSXETT00000069302", "A0A6I8QSF1", "ENSXETT00000069302", "A0A6I8QE50", "ENSXETT00000069302", "A0A6I8QMZ7", "ENSXETT00000069302", "A0A6I8Q652", "ENSXETT00000069302", "A0A6I8Q664", "ENSXETT00000069302", "A0A6I8Q2X0", "ENSXETT00000069302", "A0A6I8Q318", "ENSXETT00000069302", "A0A6I8Q0S1", "ENSXETT00000069302", "A0A6I8Q2I9", "ENSXETT00000069302", "K9J7P7", "ENSXETT00000007797", "A0A6I8PSU3", "ENSXETG00000039428", "F6S2S6", "ENSXETT00000022997", "A0A6I8Q2V3", "ENSXETG00000039428", "A0A6I8RZZ7", "ENSXETG00000039428", "A0A6I8SEP6", "ENSXETG00000039428", "A0A6I8QNA7", "ENSXETG00000039428", "A0A6I8R2R2", "ENSXETG00000039428", "A0A6I8Q7C1", "ENSXETG00000039428", "A0A6I8QD99", "ENSXETG00000039428" ] }, "reaction_10326828": { "compartment": "compartment_876", "id": "reaction_10326828", "reactome": "R-XTR-2426569", "name": "Interaction of DAP12 and IREM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326824", "species_10316092" ], "products": [ "species_10326826" ], "modifiers": [], "additional_components": [ "ENSXETG00000036363", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8SNS8", "ENSXETG00000036363" ] }, "reaction_10316104": { "compartment": "compartment_876", "id": "reaction_10316104", "reactome": "R-XTR-210300", "name": "Interaction of DAP12 and TREM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316100", "species_10316092" ], "products": [ "species_10316102" ], "modifiers": [], "additional_components": [ "ENSXETG00000037809", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QSY3", "ENSXETG00000037809" ] }, "reaction_10326264": { "compartment": "compartment_876", "id": "reaction_10326264", "reactome": "R-XTR-2172123", "name": "Interaction of SIGLEC14/15/16 and DAP12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326260", "species_10316092" ], "products": [ "species_10326262" ], "modifiers": [], "additional_components": [ "A0A6I8Q2E3", "ENSXETG00000031297", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8Q2E3", "ENSXETG00000031297", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970" ] }, "reaction_10326651": { "compartment": "compartment_876", "id": "reaction_10326651", "reactome": "R-XTR-2272668", "name": "Interaction of DAP12 and KIR2DS5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315610", "species_10316092" ], "products": [ "species_10326649" ], "modifiers": [], "additional_components": [ "ENSXETG00000032630", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8Q0D7", "ENSXETG00000032630" ] }, "reaction_10325991": { "compartment": "compartment_876", "id": "reaction_10325991", "reactome": "R-XTR-2130151", "name": "Dimerization of DAP12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315608" ], "products": [ "species_10316092" ], "modifiers": [], "additional_components": [ "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786" ] }, "reaction_10326822": { "compartment": "compartment_876", "id": "reaction_10326822", "reactome": "R-XTR-2426566", "name": "Interaction of DAP12 and CLM7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326818", "species_10316092" ], "products": [ "species_10326820" ], "modifiers": [], "additional_components": [ "ENSXETG00000036363", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8SNS8", "ENSXETG00000036363" ] }, "reaction_10316096": { "compartment": "compartment_876", "id": "reaction_10316096", "reactome": "R-XTR-210273", "name": "Interaction of DAP12 and NKp44", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316090", "species_10316092" ], "products": [ "species_10316094" ], "modifiers": [], "additional_components": [ "ENSXETG00000032041", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8QP54", "ENSXETG00000039786", "A0A6I8PSB6", "ENSXETG00000032041" ] }, "reaction_10320644": { "compartment": "compartment_17906", "id": "reaction_10320644", "reactome": "R-XTR-936564", "name": "NLRX1 inhibits MAVS-DDX58 interaction.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320640", "species_10320636" ], "products": [ "species_10320642" ], "modifiers": [], "additional_components": [ "ENSXETG00000021586", "ENSXETG00000032111", "A0A6I8PQE8", "ENSXETG00000032111", "A0A6I8PYZ4", "ENSXETG00000021586" ] }, "reaction_10338275": { "compartment": "compartment_17906", "id": "reaction_10338275", "reactome": "R-XTR-9709842", "name": "MAVS binds TOMM70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331987", "species_10320636" ], "products": [ "species_10338273" ], "modifiers": [], "additional_components": [ "ENSXETG00000011867", "ENSXETG00000032111", "A0A6I8PQE8", "ENSXETG00000032111", "A0A6I8QP49", "ENSXETG00000011867" ] }, "reaction_10333758": { "compartment": "compartment_6800424", "id": "reaction_10333758", "reactome": "R-XTR-6800426", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333750" ], "products": [ "species_10333756" ], "modifiers": [], "additional_components": [ "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8PUI6", "ENSXETG00000037491", "A0A6I8QHU4", "ENSXETG00000015523", "A0A6I8SNS8", "ENSXETG00000036363", "Q6P2W7", "ENSXETG00000024963", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "Q6GL60", "ENSXETT00000092508", "A0A6I8SYN8", "ENSXETG00000035544", "A0A6I8Q475", "ENSXETG00000035544", "A0A6I8PQG1", "ENSXETG00000034243", "A0A6I8QZT4", "ENSXETG00000015766", "F6WCE6", "ENSXETT00000002749", "Q6NVR9", "ENSXETT00000028394", "A0A6I8SS44", "ENSXETG00000034408", "A1A5G6", "ENSXETG00000007635", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q632", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "Q0VA77", "ENSXETT00000035499", "Q6P8C8", "ENSXETT00000001981", "F6WSE4", "ENSXETT00000003359", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8PQG1", "ENSXETG00000034243", "Q0VA77", "ENSXETT00000035499", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8Q632", "ENSXETG00000041332", "A0A6I8QZT4", "ENSXETG00000015766", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8QHU4", "ENSXETG00000015523", "Q6P2W7", "ENSXETG00000024963", "A0A6I8Q475", "ENSXETG00000035544", "A0A6I8SYN8", "ENSXETG00000035544", "Q6P8C8", "ENSXETT00000001981", "F6WCE6", "ENSXETT00000002749", "Q6NVR9", "ENSXETT00000028394", "Q6GL60", "ENSXETT00000092508", "A1A5G6", "ENSXETG00000007635", "F6WSE4", "ENSXETT00000003359", "A0A6I8SS44", "ENSXETG00000034408", "A0A6I8SNS8", "ENSXETG00000036363", "A0A6I8PUI6", "ENSXETG00000037491" ] }, "reaction_10333460": { "compartment": "compartment_1470028", "id": "reaction_10333460", "reactome": "R-XTR-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333416" ], "products": [ "species_10333458" ], "modifiers": [], "additional_components": [ "Q6DIW0", "ENSXETT00000053781", "A0A6I8PNH6", "ENSXETG00000034056", "A4QNN7", "ENSXETT00000010246", "A0A6I8Q3I4", "ENSXETG00000032992", "Q6GLE7", "ENSXETT00000052187", "Q28FE0", "ENSXETT00000019617", "F6SF13", "ENSXETT00000019894", "F7EHU5", "ENSXETT00000037000", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8Q1T5", "ENSXETG00000014900", "A0A6I8T0D3", "ENSXETG00000001184", "F6YPC2", "ENSXETT00000038130", "A0A6I8S033", "ENSXETG00000009423", "A0A6I8QUN5", "ENSXETG00000039169", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "A0A6I8QPJ5", "ENSXETG00000039590", "A0A6I8RBC3", "ENSXETG00000037351", "Q5HZU5", "ENSXETT00000093455", "Q5BL41", "ENSXETT00000030571", "A0A6I8RID5", "ENSXETG00000037293", "A0A6I8QAR5", "ENSXETG00000003287", "Q6P4K6", "ENSXETG00000007155", "A0A6I8PSL2", "ENSXETG00000026399", "F6T7W4", "ENSXETT00000045926", "F7DYP1", "ENSXETT00000013582", "Q28BP9", "ENSXETG00000010945", "L7N3U2", "ENSXETT00000047429", "A0A6I8R6T7", "ENSXETG00000038487", "Q6DFR0", "ENSXETT00000010030", "Q6GL04", "ENSXETT00000067185", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "A0A6I8RID5", "ENSXETG00000037293", "A0A6I8QUN5", "ENSXETG00000039169", "L7N3U2", "ENSXETT00000047429", "A0A6I8Q3I4", "ENSXETG00000032992", "Q6GLE7", "ENSXETT00000052187", "Q6DIW0", "ENSXETT00000053781", "A0A6I8S033", "ENSXETG00000009423", "A0A6I8Q1T5", "ENSXETG00000014900", "F6SF13", "ENSXETT00000019894", "Q6P4K6", "ENSXETG00000007155", "F6YPC2", "ENSXETT00000038130", "A0A6I8QPJ5", "ENSXETG00000039590", "A0A6I8RBC3", "ENSXETG00000037351", "Q5HZU5", "ENSXETT00000093455", "F6T7W4", "ENSXETT00000045926", "F7DYP1", "ENSXETT00000013582", "A0A6I8PSL2", "ENSXETG00000026399", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8R6T7", "ENSXETG00000038487", "A4QNN7", "ENSXETT00000010246", "Q28BP9", "ENSXETG00000010945", "A0A6I8PNH6", "ENSXETG00000034056", "Q6DFR0", "ENSXETT00000010030", "A0A6I8T0D3", "ENSXETG00000001184", "Q28FE0", "ENSXETT00000019617", "A0A6I8QAR5", "ENSXETG00000003287", "F7EHU5", "ENSXETT00000037000", "Q5BL41", "ENSXETT00000030571", "Q6GL04", "ENSXETT00000067185" ] }, "reaction_10332598": { "compartment": "compartment_6798757", "id": "reaction_10332598", "reactome": "R-XTR-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10332572" ], "products": [ "species_10332596" ], "modifiers": [], "additional_components": [ "B1H3C9", "ENSXETG00000019826", "A0A6I8R329", "ENSXETG00000038658", "A0A6I8SB02", "ENSXETG00000038658", "A0A6I8PPZ5", "ENSXETG00000038658", "A0A6I8QZM7", "ENSXETG00000032631", "Q6P8C8", "ENSXETT00000001981", "Q640R7", "ENSXETT00000104159", "A0A1B8Y5B7", "ENSXETT00000104043", "F6WCE6", "ENSXETT00000002749", "A0A6I8RRU8", "ENSXETG00000035335", "Q6P2W7", "ENSXETG00000024963", "A0A6I8SFY1", "ENSXETG00000002247", "A0A6I8PML7", "ENSXETG00000027247", "A0A6I8QSY3", "ENSXETG00000037809", "F7AHQ1", "ENSXETT00000007782", "F6PX96", "ENSXETT00000016673", "F6ULZ5", "ENSXETT00000023447", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8Q632", "ENSXETG00000041332", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8SFY1", "ENSXETG00000002247", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8Q632", "ENSXETG00000041332", "A0A6I8R329", "ENSXETG00000038658", "A0A6I8PPZ5", "ENSXETG00000038658", "A0A6I8QZM7", "ENSXETG00000032631", "A0A6I8SB02", "ENSXETG00000038658", "Q640R7", "ENSXETT00000104159", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8PWE5", "ENSXETG00000033504", "F6ULZ5", "ENSXETT00000023447", "Q6P2W7", "ENSXETG00000024963", "A0A1B8Y5B7", "ENSXETT00000104043", "Q6P8C8", "ENSXETT00000001981", "F6WCE6", "ENSXETT00000002749", "A0A6I8RRU8", "ENSXETG00000035335", "F7AHQ1", "ENSXETT00000007782", "F6PX96", "ENSXETT00000016673", "A0A6I8PML7", "ENSXETG00000027247", "B1H3C9", "ENSXETG00000019826", "A0A6I8QSY3", "ENSXETG00000037809" ] }, "reaction_10333222": { "compartment": "compartment_1462052", "id": "reaction_10333222", "reactome": "R-XTR-6798748", "name": "Exocytosis of secretory granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333156" ], "products": [ "species_10333220" ], "modifiers": [], "additional_components": [ "Q6DEU1", "ENSXETT00000058038", "Q6P326", "ENSXETG00000021646", "A0A6I8Q5Z6", "ENSXETG00000031325", "A0A6I8SM68", "ENSXETG00000032580", "A0A6I8RCL3", "ENSXETG00000006695", "F7B3J1", "ENSXETT00000011348", "A0A6I8R1G6", "ENSXETG00000007490", "A0A6I8QYH5", "ENSXETG00000035070", "A0A6I8SRS9", "ENSXETG00000016932", "A0A6I8Q0D7", "ENSXETG00000032630", "Q28IX9", "ENSXETT00000096095", "A0A6I8QJX8", "ENSXETG00000010896", "L7N2L6", "ENSXETT00000005874", "A0A6I8S033", "ENSXETG00000009423", "A0A6I8SJ17", "ENSXETG00000016072", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8RMU5", "ENSXETG00000041054", "A0A6I8QYQ6", "ENSXETG00000037779", "A0A6I8RU72", "ENSXETG00000041054", "A0A6I8RSU0", "ENSXETG00000041054", "A0A6I8QAR5", "ENSXETG00000003287", "Q6GL04", "ENSXETT00000067185", "A0A6I8SZP6", "ENSXETG00000021325", "F6TGE8", "ENSXETT00000000571", "A0A6I8SR75", "ENSXETG00000037123", "A0A6I8SKX0", "ENSXETG00000018552", "A0A6I8RTF4", "ENSXETG00000038059", "F7BED4", "ENSXETT00000050679", "A0A6I8RKW5", "ENSXETG00000019013", "Q4V9Y5", "ENSXETT00000029363", "A0A6I8SN57", "ENSXETG00000037611", "A0A6I8QFG6", "ENSXETG00000037805", "Q5I0S8", "ENSXETT00000001376", "A0A6I8Q5Z6", "ENSXETG00000031325", "A0A6I8SRS9", "ENSXETG00000016932", "F7B3J1", "ENSXETT00000011348", "A0A6I8RKW5", "ENSXETG00000019013", "A0A6I8QJX8", "ENSXETG00000010896", "L7N2L6", "ENSXETT00000005874", "A0A6I8RSU0", "ENSXETG00000041054", "A0A6I8RU72", "ENSXETG00000041054", "A0A6I8QYQ6", "ENSXETG00000037779", "A0A6I8RMU5", "ENSXETG00000041054", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8SJ17", "ENSXETG00000016072", "A0A6I8SN57", "ENSXETG00000037611", "A0A6I8S033", "ENSXETG00000009423", "A0A6I8RTF4", "ENSXETG00000038059", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8SR75", "ENSXETG00000037123", "Q4V9Y5", "ENSXETT00000029363", "F7BED4", "ENSXETT00000050679", "A0A6I8QFG6", "ENSXETG00000037805", "A0A6I8SM68", "ENSXETG00000032580", "Q6DEU1", "ENSXETT00000058038", "Q6P326", "ENSXETG00000021646", "A0A6I8RCL3", "ENSXETG00000006695", "A0A6I8R1G6", "ENSXETG00000007490", "Q28IX9", "ENSXETT00000096095", "A0A6I8QYH5", "ENSXETG00000035070", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8QAR5", "ENSXETG00000003287", "F6TGE8", "ENSXETT00000000571", "Q6GL04", "ENSXETT00000067185", "A0A6I8SKX0", "ENSXETG00000018552", "Q5I0S8", "ENSXETT00000001376" ] }, "reaction_10333312": { "compartment": "compartment_6799371", "id": "reaction_10333312", "reactome": "R-XTR-6798749", "name": "Exocytosis of specific granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333294" ], "products": [ "species_10333310" ], "modifiers": [], "additional_components": [ "A0A6I8QDT0", "ENSXETG00000039678", "A0A6I8SHN1", "ENSXETG00000035535", "Q6P8G1", "ENSXETG00000014290", "Q5HZU5", "ENSXETT00000093455", "A0A6I8QPJ5", "ENSXETG00000039590", "A0A6I8RBC3", "ENSXETG00000037351", "A0A6I8QJ14", "ENSXETG00000036342", "A0A6I8RZ58", "ENSXETG00000038864", "Q6DFR0", "ENSXETT00000010030", "A0A6I8SZP6", "ENSXETG00000021325", "F6PTR9", "ENSXETT00000028682", "F7D5C5", "ENSXETT00000001620", "A0A6I8Q0D7", "ENSXETG00000032630", "F6TPK8", "ENSXETT00000008283", "Q5BKE6", "ENSXETT00000089406", "A0A6I8PKK9", "ENSXETG00000033246", "Q28IE5", "ENSXETG00000011864", "A0A6I8R549", "ENSXETG00000011988", "A0A6I8SVI1", "ENSXETG00000012869", "A0A6I8PV16", "ENSXETG00000031089", "A0A6I8REW5", "ENSXETG00000017331", "Q5M7S9", "ENSXETT00000073387", "A0A6I8RCC1", "ENSXETG00000006576", "A0A6I8RID5", "ENSXETG00000037293", "Q501K5", "ENSXETG00000011814", "F7DYP1", "ENSXETT00000013582", "A0A6I8PKK9", "ENSXETG00000033246", "F6TPK8", "ENSXETT00000008283", "Q501K5", "ENSXETG00000011814", "F7DYP1", "ENSXETT00000013582", "A0A6I8RID5", "ENSXETG00000037293", "A0A6I8SVI1", "ENSXETG00000012869", "A0A6I8R549", "ENSXETG00000011988", "A0A6I8QDT0", "ENSXETG00000039678", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8REW5", "ENSXETG00000017331", "A0A6I8RZ58", "ENSXETG00000038864", "A0A6I8QJ14", "ENSXETG00000036342", "F6PTR9", "ENSXETT00000028682", "Q6DFR0", "ENSXETT00000010030", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8RCC1", "ENSXETG00000006576", "Q5M7S9", "ENSXETT00000073387", "A0A6I8RBC3", "ENSXETG00000037351", "Q5HZU5", "ENSXETT00000093455", "A0A6I8QPJ5", "ENSXETG00000039590", "F7D5C5", "ENSXETT00000001620", "Q5BKE6", "ENSXETT00000089406", "Q6P8G1", "ENSXETG00000014290", "A0A6I8Q0D7", "ENSXETG00000032630", "Q28IE5", "ENSXETG00000011864", "A0A6I8PV16", "ENSXETG00000031089" ] }, "reaction_10333904": { "compartment": "compartment_984", "id": "reaction_10333904", "reactome": "R-XTR-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333882" ], "products": [ "species_10333902" ], "modifiers": [], "additional_components": [ "F6TFI0", "ENSXETT00000050806", "F7B3J1", "ENSXETT00000011348", "A0A6I8QYH5", "ENSXETG00000035070", "L7N3U2", "ENSXETT00000047429", "L7N2L6", "ENSXETT00000005874", "Q28IX9", "ENSXETT00000096095", "A0A6I8SRS9", "ENSXETG00000016932", "Q6P8G1", "ENSXETG00000014290", "A0A6I8SJ17", "ENSXETG00000016072", "Q5BL41", "ENSXETT00000030571", "A0A6I8QJX8", "ENSXETG00000010896", "A0A6I8RSU0", "ENSXETG00000041054", "A0A6I8RU72", "ENSXETG00000041054", "A0A6I8QYQ6", "ENSXETG00000037779", "A0A6I8RMU5", "ENSXETG00000041054", "A0A6I8RCC1", "ENSXETG00000006576", "Q5M7S9", "ENSXETT00000073387", "F6PKQ4", "ENSXETT00000023697", "F6PTR9", "ENSXETT00000028682", "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566", "A0A6I8SKX0", "ENSXETG00000018552", "A0A6I8SR75", "ENSXETG00000037123", "F6T7W4", "ENSXETT00000045926", "Q6GL04", "ENSXETT00000067185", "F6TGE8", "ENSXETT00000000571", "B1H326", "ENSXETT00000060143", "A0A6I8RKW5", "ENSXETG00000019013", "A0A6I8RTF4", "ENSXETG00000038059", "A0A6I8SN57", "ENSXETG00000037611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8RI96", "ENSXETG00000038203", "F7BED4", "ENSXETT00000050679", "A0A6I8PT30", "ENSXETG00000003014", "Q4V9Y5", "ENSXETT00000029363", "A0A6I8QFG6", "ENSXETG00000037805", "A0A6I8SM87", "ENSXETG00000038128", "A0A6I8RUR5", "ENSXETG00000035955", "B5DE93", "ENSXETG00000023695", "A0A6I8R1G6", "ENSXETG00000007490", "A0A6I8QL92", "ENSXETG00000039008", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350", "Q6DEU1", "ENSXETT00000058038", "Q6P326", "ENSXETG00000021646", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8RCL3", "ENSXETG00000006695", "F6PKQ4", "ENSXETT00000023697", "A0A6I8SRS9", "ENSXETG00000016932", "F7B3J1", "ENSXETT00000011348", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "A0A6I8RKW5", "ENSXETG00000019013", "A0A6I8QJX8", "ENSXETG00000010896", "F6T7W4", "ENSXETT00000045926", "L7N2L6", "ENSXETT00000005874", "L7N3U2", "ENSXETT00000047429", "A0A6I8PT30", "ENSXETG00000003014", "A0A6I8RSU0", "ENSXETG00000041054", "A0A6I8RU72", "ENSXETG00000041054", "A0A6I8QYQ6", "ENSXETG00000037779", "A0A6I8RMU5", "ENSXETG00000041054", "A0A6I8RUR5", "ENSXETG00000035955", "A0A6I8SJ17", "ENSXETG00000016072", "A0A6I8RCC1", "ENSXETG00000006576", "Q5M7S9", "ENSXETT00000073387", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8SN57", "ENSXETG00000037611", "A0A6I8RTF4", "ENSXETG00000038059", "Q6P8G1", "ENSXETG00000014290", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8SR75", "ENSXETG00000037123", "A0A6I8SM87", "ENSXETG00000038128", "Q4V9Y5", "ENSXETT00000029363", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350", "A0A6I8QL92", "ENSXETG00000039008", "F7BED4", "ENSXETT00000050679", "B1H326", "ENSXETT00000060143", "F6TFI0", "ENSXETT00000050806", "A0A6I8QFG6", "ENSXETG00000037805", "B5DE93", "ENSXETG00000023695", "Q6DEU1", "ENSXETT00000058038", "Q6P326", "ENSXETG00000021646", "A0A6I8RCL3", "ENSXETG00000006695", "F6PTR9", "ENSXETT00000028682", "A0A6I8R1G6", "ENSXETG00000007490", "Q28IX9", "ENSXETT00000096095", "A0A6I8QYH5", "ENSXETG00000035070", "F6TGE8", "ENSXETT00000000571", "Q6GL04", "ENSXETT00000067185", "Q5BL41", "ENSXETT00000030571", "A0A6I8SKX0", "ENSXETG00000018552" ] }, "reaction_10332768": { "compartment": "compartment_876", "id": "reaction_10332768", "reactome": "R-XTR-6798743", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10332852" ], "products": [ "species_10332896" ], "modifiers": [], "additional_components": [ "Q5BKE6", "ENSXETT00000089406", "A0A6I8SVI1", "ENSXETG00000012869", "A0A6I8Q0D7", "ENSXETG00000032630", "Q501K5", "ENSXETG00000011814", "F7D5C5", "ENSXETT00000001620", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8QDT0", "ENSXETG00000039678", "Q6P8G1", "ENSXETG00000014290", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "Q5M7S9", "ENSXETT00000073387", "A0A6I8RCC1", "ENSXETG00000006576", "F6PKQ4", "ENSXETT00000023697", "A0A6I8PKK9", "ENSXETG00000033246", "F6T7W4", "ENSXETT00000045926", "A0A6I8SN57", "ENSXETG00000037611", "F6PTR9", "ENSXETT00000028682", "A0A6I8RKW5", "ENSXETG00000019013", "Q28IE5", "ENSXETG00000011864", "A0A6I8PT30", "ENSXETG00000003014", "A0A6I8RID5", "ENSXETG00000037293", "A0A6I8PV16", "ENSXETG00000031089", "A0A6I8RUR5", "ENSXETG00000035955", "A0A6I8PKK9", "ENSXETG00000033246", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "F6PKQ4", "ENSXETT00000023697", "Q501K5", "ENSXETG00000011814", "A0A6I8RID5", "ENSXETG00000037293", "A0A6I8SVI1", "ENSXETG00000012869", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "A0A6I8QDT0", "ENSXETG00000039678", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8RKW5", "ENSXETG00000019013", "F6PTR9", "ENSXETT00000028682", "F6T7W4", "ENSXETT00000045926", "A0A6I8PT30", "ENSXETG00000003014", "A0A6I8RUR5", "ENSXETG00000035955", "A0A6I8RCC1", "ENSXETG00000006576", "Q5M7S9", "ENSXETT00000073387", "A0A6I8SN57", "ENSXETG00000037611", "F7D5C5", "ENSXETT00000001620", "Q5BKE6", "ENSXETT00000089406", "Q6P8G1", "ENSXETG00000014290", "A0A6I8Q0D7", "ENSXETG00000032630", "Q28IE5", "ENSXETG00000011864", "A0A6I8PV16", "ENSXETG00000031089" ] }, "reaction_10333042": { "compartment": "compartment_6799713", "id": "reaction_10333042", "reactome": "R-XTR-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10333006" ], "products": [ "species_10333040" ], "modifiers": [], "additional_components": [ "F6ZRG8", "ENSXETT00000037913", "A0A6I8PUI6", "ENSXETG00000037491", "A0A6I8PVI0", "ENSXETG00000010850", "A0A1B8Y5B7", "ENSXETT00000104043", "A0A6I8Q475", "ENSXETG00000035544", "A0A6I8SYN8", "ENSXETG00000035544", "A0A6I8Q0D7", "ENSXETG00000032630", "F6TV21", "ENSXETT00000001805", "B0BM39", "ENSXETT00000065869", "A0A6I8SMJ1", "ENSXETG00000040970", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8PYT1", "ENSXETG00000036665", "A0A6I8SS44", "ENSXETG00000034408", "Q28H62", "ENSXETT00000054186", "F6WCE6", "ENSXETT00000002749", "B4F6Y3", "ENSXETG00000026765", "A0A6I8SNS8", "ENSXETG00000036363", "A0A6I8SCB5", "ENSXETG00000018128", "Q6DF40", "ENSXETG00000020403", "A0A6I8PZB2", "ENSXETG00000001905", "A0A6I8SB02", "ENSXETG00000038658", "A0A6I8QZM7", "ENSXETG00000032631", "A0A6I8R329", "ENSXETG00000038658", "A0A6I8PPZ5", "ENSXETG00000038658", "A0A6I8QHU4", "ENSXETG00000015523", "A0A6I8SNU5", "ENSXETG00000031444", "A0A6I8PVI0", "ENSXETG00000010850", "A0A6I8Q0D7", "ENSXETG00000032630", "A0A6I8SNU5", "ENSXETG00000031444", "A0A6I8PYT1", "ENSXETG00000036665", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8R329", "ENSXETG00000038658", "A0A6I8PPZ5", "ENSXETG00000038658", "A0A6I8QZM7", "ENSXETG00000032631", "A0A6I8SB02", "ENSXETG00000038658", "B4F6Y3", "ENSXETG00000026765", "A0A6I8R800", "ENSXETG00000040970", "A0A6I8S878", "ENSXETG00000040970", "A0A6I8SMJ1", "ENSXETG00000040970", "Q28H62", "ENSXETT00000054186", "A0A6I8QHU4", "ENSXETG00000015523", "A0A6I8Q475", "ENSXETG00000035544", "A0A6I8SYN8", "ENSXETG00000035544", "Q6DF40", "ENSXETG00000020403", "A0A6I8SCB5", "ENSXETG00000018128", "A0A6I8SNS8", "ENSXETG00000036363", "A0A6I8PUI6", "ENSXETG00000037491", "A0A6I8PZB2", "ENSXETG00000001905", "A0A1B8Y5B7", "ENSXETT00000104043", "B0BM39", "ENSXETT00000065869", "F6WCE6", "ENSXETT00000002749", "F6TV21", "ENSXETT00000001805", "F6ZRG8", "ENSXETT00000037913", "A0A6I8SS44", "ENSXETG00000034408" ] }, "reaction_10320878": { "compartment": "compartment_876", "id": "reaction_10320878", "reactome": "R-XTR-981713", "name": "C4b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313268", "species_983438" ], "products": [ "species_10313290" ], "modifiers": [], "additional_components": [ "A0A6I8Q4R4", "ENSXETG00000005203", "A0A6I8Q4R4", "ENSXETG00000005203" ] }, "reaction_10313294": { "compartment": "compartment_984", "id": "reaction_10313294", "reactome": "R-XTR-166795", "name": "Formation of Classical C3 convertase (C4b:C2a complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313290", "species_10313274" ], "products": [ "species_10313292" ], "modifiers": [], "additional_components": [ "A0A6I8Q4R4", "ENSXETG00000005203", "ENSXETG00000041348", "A0A6I8R253", "ENSXETG00000041348", "A0A6I8Q4R4", "ENSXETG00000005203" ] }, "reaction_10313469": { "compartment": "compartment_984", "id": "reaction_10313469", "reactome": "R-XTR-173745", "name": "Factor D cleaves C3(H2O)-bound Factor B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313458" ], "products": [ "species_10313462", "species_10313320" ], "modifiers": [ [ "species_10313466", "catalyst" ] ], "additional_components": [ "A0A6I8S693", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "ENSXETG00000039379", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "ENSXETG00000021646" ] }, "reaction_10313981": { "compartment": "compartment_984", "id": "reaction_10313981", "reactome": "R-XTR-183126", "name": "Factor B binds to surface-associated C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313456", "species_10313326" ], "products": [ "species_10313977" ], "modifiers": [], "additional_components": [ "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379" ] }, "reaction_10320876": { "compartment": "compartment_876", "id": "reaction_10320876", "reactome": "R-XTR-981539", "name": "C3b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313307", "species_983438" ], "products": [ "species_10313326" ], "modifiers": [], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992" ] }, "reaction_10313454": { "compartment": "compartment_984", "id": "reaction_10313454", "reactome": "R-XTR-173739", "name": "Spontaneous hydrolysis of C3 thioester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10313303" ], "products": [ "species_10313314" ], "modifiers": [], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992" ] }, "reaction_10313979": { "compartment": "compartment_876", "id": "reaction_10313979", "reactome": "R-XTR-183122", "name": "Factor D cleaves C3b-bound Factor B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313977" ], "products": [ "species_10313462", "species_10313324" ], "modifiers": [ [ "species_10313466", "catalyst" ] ], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "ENSXETG00000021646" ] }, "reaction_10313460": { "compartment": "compartment_984", "id": "reaction_10313460", "reactome": "R-XTR-173740", "name": "Factor B binds to C3(H2O)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313314", "species_10313456" ], "products": [ "species_10313458" ], "modifiers": [], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "ENSXETG00000039379", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992" ] }, "reaction_10313984": { "compartment": "compartment_984", "id": "reaction_10313984", "reactome": "R-XTR-183130", "name": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313303" ], "products": [ "species_10313307", "species_10313309" ], "modifiers": [ [ "species_10313320", "catalyst" ] ], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992" ] }, "reaction_10334989": { "compartment": "compartment_876", "id": "reaction_10334989", "reactome": "R-XTR-8851436", "name": "CFHR dimers bind C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334985", "species_10313326" ], "products": [ "species_10334987" ], "modifiers": [], "additional_components": [ "A0A6I8PQF3", "ENSXETG00000031728", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10321772": { "compartment": "compartment_876", "id": "reaction_10321772", "reactome": "R-XTR-1006169", "name": "Factor H binds host cell surface markers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320787", "species_1006146" ], "products": [ "species_10320851" ], "modifiers": [], "additional_components": [ "ENSXETG00000031728", "species_1604784", "species_1006168", "species_1604784", "species_1006168", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10320856": { "compartment": "compartment_876", "id": "reaction_10320856", "reactome": "R-XTR-977605", "name": "Factor H displaces Bb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320849" ], "products": [ "species_10313318", "species_10320847" ], "modifiers": [], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8PQF3", "ENSXETG00000031728", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10320853": { "compartment": "compartment_876", "id": "reaction_10320853", "reactome": "R-XTR-977363", "name": "Factor H binds to C3bBb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320787", "species_10313324" ], "products": [ "species_10320849" ], "modifiers": [ [ "species_10320851", "catalyst" ] ], "additional_components": [ "ENSXETG00000031728", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8PQF3", "ENSXETG00000031728", "species_1604784", "species_1006168", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10320791": { "compartment": "compartment_984", "id": "reaction_10320791", "reactome": "R-XTR-976768", "name": "Factor H binds to C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320787", "species_10313307" ], "products": [ "species_10320789" ], "modifiers": [], "additional_components": [ "ENSXETG00000031728", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10320880": { "compartment": "compartment_876", "id": "reaction_10320880", "reactome": "R-XTR-981728", "name": "Factor H binds to membrane-associated C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320787", "species_10313326" ], "products": [ "species_10320847" ], "modifiers": [ [ "species_10320851", "catalyst" ] ], "additional_components": [ "ENSXETG00000031728", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8PQF3", "ENSXETG00000031728", "species_1604784", "species_1006168", "A0A6I8PQF3", "ENSXETG00000031728" ] }, "reaction_10327043": { "compartment": "compartment_984", "id": "reaction_10327043", "reactome": "R-XTR-2855047", "name": "Hydrolysis of internal thioester in C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10313268" ], "products": [ "species_10313281" ], "modifiers": [], "additional_components": [ "A0A6I8Q4R4", "ENSXETG00000005203", "A0A6I8Q4R4", "ENSXETG00000005203" ] }, "reaction_10313452": { "compartment": "compartment_876", "id": "reaction_10313452", "reactome": "R-XTR-173636", "name": "Formation of classic pathway C5 convertase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313326", "species_10313292" ], "products": [ "species_10313328" ], "modifiers": [], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8R253", "ENSXETG00000041348", "A0A6I8Q4R4", "ENSXETG00000005203", "A0A6I8R253", "ENSXETG00000041348", "A0A6I8Q4R4", "ENSXETG00000005203", "A0A6I8Q3I4", "ENSXETG00000032992" ] }, "reaction_10313333": { "compartment": "compartment_984", "id": "reaction_10313333", "reactome": "R-XTR-166817", "name": "Cleavage of C3 by C3 convertases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313303" ], "products": [ "species_10313307", "species_10313309" ], "modifiers": [ [ "species_10313330", "catalyst" ] ], "additional_components": [ "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "ENSXETG00000032992", "A0A6I8Q3I4", "ENSXETG00000032992", "A0A6I8S693", "ENSXETG00000039379", "A0A6I8R253", "ENSXETG00000041348", "A0A6I8Q4R4", "ENSXETG00000005203" ] }, "reaction_10337951": { "compartment": "compartment_70101", "id": "reaction_10337951", "reactome": "R-XTR-9645394", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312116" ], "products": [ "species_10313391" ], "modifiers": [ [ "species_10337948", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "Q28DL4", "ENSXETG00000007549" ] }, "reaction_10337966": { "compartment": "compartment_70101", "id": "reaction_10337966", "reactome": "R-XTR-9645501", "name": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320680", "species_10337964" ], "products": [ "species_10337953" ], "modifiers": [], "additional_components": [ "ENSXETG00000007549", "Q28DL4", "ENSXETG00000007549", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "Q28DL4", "ENSXETG00000007549", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337976": { "compartment": "compartment_70101", "id": "reaction_10337976", "reactome": "R-XTR-9645524", "name": "ALPK1:ADP-heptose binds TIFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337937", "species_10337972" ], "products": [ "species_10337974" ], "modifiers": [], "additional_components": [ "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "B5DE70", "ENSXETT00000052013", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337979": { "compartment": "compartment_70101", "id": "reaction_10337979", "reactome": "R-XTR-9645535", "name": "ALPK1 phosphorylates TIFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337974", "species_113592" ], "products": [ "species_29370", "species_10337960" ], "modifiers": [ [ "species_10337974", "catalyst" ] ], "additional_components": [ "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337962": { "compartment": "compartment_70101", "id": "reaction_10337962", "reactome": "R-XTR-9645481", "name": "TIFA oligomerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337960" ], "products": [ "species_10337946" ], "modifiers": [], "additional_components": [ "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337956": { "compartment": "compartment_70101", "id": "reaction_10337956", "reactome": "R-XTR-9645414", "name": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337953", "species_10312116" ], "products": [ "species_10337948" ], "modifiers": [ [ "species_10337953", "catalyst" ] ], "additional_components": [ "Q28DL4", "ENSXETG00000007549", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "Q28DL4", "ENSXETG00000007549", "Q28DL4", "ENSXETG00000007549", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337958": { "compartment": "compartment_70101", "id": "reaction_10337958", "reactome": "R-XTR-9645428", "name": "ALPK1 binds ADP-heptose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9645519", "species_10337935" ], "products": [ "species_10337937" ], "modifiers": [], "additional_components": [ "ENSXETG00000024103", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10337968": { "compartment": "compartment_70101", "id": "reaction_10337968", "reactome": "R-XTR-9645520", "name": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337946", "species_10320680" ], "products": [ "species_10337964" ], "modifiers": [], "additional_components": [ "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519", "ENSXETG00000007549", "Q28DL4", "ENSXETG00000007549", "B5DE70", "ENSXETT00000052013", "A0A6I8QX94", "ENSXETG00000024103", "species_9645519" ] }, "reaction_10330607": { "compartment": "compartment_70101", "id": "reaction_10330607", "reactome": "R-XTR-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10324029", "catalyst" ] ], "additional_components": [ "ENSXETG00000016428" ] }, "reaction_10330623": { "compartment": "compartment_5683628", "id": "reaction_10330623", "reactome": "R-XTR-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330602" ], "products": [ "species_10330621" ], "modifiers": [ [ "species_10320527", "catalyst" ] ], "additional_components": [ "species_8959490", "Q5BIZ2", "ENSXETT00000083554", "Q28FC7", "ENSXETT00000085573", "Q5BIZ2", "ENSXETT00000083554", "Q28FC7", "ENSXETT00000085573", "species_8959490", "Q5FW14", "ENSXETG00000016810", "Q5BKM3", "ENSXETT00000038990", "Q6NVL7", "ENSXETT00000016617", "Q6DFS6", "ENSXETT00000041697", "Q6GL11", "ENSXETG00000021424" ] }, "reaction_10336858": { "compartment": "compartment_70101", "id": "reaction_10336858", "reactome": "R-XTR-8948139", "name": "p-S13-FUNDC1 is dephosphorylated by PGAM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336847" ], "products": [ "species_10336844" ], "modifiers": [ [ "species_10336855", "catalyst" ] ], "additional_components": [ "ENSXETG00000004831", "ENSXETG00000004831", "ENSXETG00000023845" ] }, "reaction_10336851": { "compartment": "compartment_17906", "id": "reaction_10336851", "reactome": "R-XTR-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330653" ], "products": [ "species_10336849" ], "modifiers": [], "additional_components": [ "ENSXETG00000002028", "ENSXETG00000002028" ] }, "reaction_10336867": { "compartment": "compartment_17906", "id": "reaction_10336867", "reactome": "R-XTR-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10336844" ], "products": [ "species_10336864", "species_29370" ], "modifiers": [ [ "species_10336849", "catalyst" ] ], "additional_components": [ "ENSXETG00000004831", "ENSXETG00000004831", "ENSXETG00000002028" ] }, "reaction_10330657": { "compartment": "compartment_70101", "id": "reaction_10330657", "reactome": "R-XTR-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330651" ], "products": [ "species_29372", "species_10330655" ], "modifiers": [], "additional_components": [ "A0A6I8QPJ0", "ENSXETG00000002028", "A4IIM9", "ENSXETT00000004248", "A0A6I8QPJ0", "ENSXETG00000002028", "A4IIM9", "ENSXETT00000004248" ] }, "reaction_10337853": { "compartment": "compartment_7660", "id": "reaction_10337853", "reactome": "R-XTR-9629195", "name": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337843", "species_10337849" ], "products": [ "species_10337851" ], "modifiers": [], "additional_components": [ "ENSXETG00000030606", "Q28D37", "ENSXETT00000104494", "A0A6I8RKR7", "ENSXETG00000035354", "B8QB46", "ENSXETG00000012487", "A0A6I8PVF6", "ENSXETG00000031339", "F7E8S9", "ENSXETT00000020406", "Q28D37", "ENSXETT00000104494", "A0A6I8RKR7", "ENSXETG00000035354", "B8QB46", "ENSXETG00000012487", "A0A6I8PVF6", "ENSXETG00000031339", "F7E8S9", "ENSXETT00000020406", "A0A6I8Q015", "ENSXETG00000030606" ] }, "reaction_10337864": { "compartment": "compartment_7660", "id": "reaction_10337864", "reactome": "R-XTR-9629216", "name": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337851" ], "products": [ "species_10337861", "species_9629218" ], "modifiers": [ [ "species_10337851", "catalyst" ] ], "additional_components": [ "Q28D37", "ENSXETT00000104494", "A0A6I8RKR7", "ENSXETG00000035354", "B8QB46", "ENSXETG00000012487", "A0A6I8PVF6", "ENSXETG00000031339", "F7E8S9", "ENSXETT00000020406", "A0A6I8Q015", "ENSXETG00000030606", "A0A6I8Q015", "ENSXETG00000030606", "Q28D37", "ENSXETT00000104494", "A0A6I8RKR7", "ENSXETG00000035354", "B8QB46", "ENSXETG00000012487", "A0A6I8PVF6", "ENSXETG00000031339", "F7E8S9", "ENSXETT00000020406", "Q28D37", "ENSXETT00000104494", "A0A6I8RKR7", "ENSXETG00000035354", "B8QB46", "ENSXETG00000012487", "A0A6I8PVF6", "ENSXETG00000031339", "F7E8S9", "ENSXETT00000020406", "A0A6I8Q015", "ENSXETG00000030606" ] }, "reaction_10312491": { "compartment": "compartment_7660", "id": "reaction_10312491", "reactome": "R-XTR-110246", "name": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312486" ], "products": [ "species_5635947", "species_10312488" ], "modifiers": [ [ "species_10312486", "catalyst" ] ], "additional_components": [ "A0A6I8QBS0", "ENSXETG00000003533", "A0A6I8QBS0", "ENSXETG00000003533", "A0A6I8QBS0", "ENSXETG00000003533" ] }, "reaction_10337882": { "compartment": "compartment_7660", "id": "reaction_10337882", "reactome": "R-XTR-9629492", "name": "NEIL3 cleaves spiroiminodihydantoin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337879" ], "products": [ "species_9629439", "species_10337872" ], "modifiers": [ [ "species_10337879", "catalyst" ] ], "additional_components": [ "A0A6I8Q015", "ENSXETG00000030606", "A0A6I8Q015", "ENSXETG00000030606", "A0A6I8Q015", "ENSXETG00000030606" ] }, "reaction_10337875": { "compartment": "compartment_7660", "id": "reaction_10337875", "reactome": "R-XTR-9629470", "name": "NEIL3 cleaves 5-guanidinohydantoin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337868" ], "products": [ "species_10337872", "species_9629218" ], "modifiers": [ [ "species_10337868", "catalyst" ] ], "additional_components": [ "A0A6I8Q015", "ENSXETG00000030606", "A0A6I8Q015", "ENSXETG00000030606", "A0A6I8Q015", "ENSXETG00000030606" ] }, "reaction_10328441": { "compartment": "compartment_7660", "id": "reaction_10328441", "reactome": "R-XTR-4085350", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10327128" ], "products": [ "species_10328439", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328589": { "compartment": "compartment_7660", "id": "reaction_10328589", "reactome": "R-XTR-4551648", "name": "SUMOylation of TDG with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10312379" ], "products": [ "species_10328587", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000025927", "Q6DEP7", "ENSXETG00000022072", "A0A6I8RWH5", "ENSXETG00000025927", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328620": { "compartment": "compartment_7660", "id": "reaction_10328620", "reactome": "R-XTR-4568848", "name": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328610", "species_10327136" ], "products": [ "species_10328618", "species_10327128" ], "modifiers": [ [ "species_10328508", "catalyst" ] ], "additional_components": [ "ENSXETT00000057859", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "A8WH10", "ENSXETT00000057859", "ENSXETT00000054232", "ENSXETG00000021519" ] }, "reaction_10327230": { "compartment": "compartment_7660", "id": "reaction_10327230", "reactome": "R-XTR-3000433", "name": "SUMOylation of PML with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327222", "species_10327188" ], "products": [ "species_10327227", "species_10327128" ], "modifiers": [ [ "species_10327222", "catalyst" ] ], "additional_components": [ "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000039978", "ENSXETG00000039978", "ENSXETT00000054232", "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328606": { "compartment": "compartment_7660", "id": "reaction_10328606", "reactome": "R-XTR-4551738", "name": "SUMOylation of TDG with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328443", "species_10312379" ], "products": [ "species_10327128", "species_10328604" ], "modifiers": [ [ "species_10328443", "catalyst" ] ], "additional_components": [ "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462", "ENSXETG00000025927", "ENSXETT00000054232", "ENSXETG00000025927", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462" ] }, "reaction_10328632": { "compartment": "compartment_7660", "id": "reaction_10328632", "reactome": "R-XTR-4568863", "name": "SUMOylation of RAD52 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10312157" ], "products": [ "species_10328630", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000009413", "Q6DEP7", "ENSXETG00000022072", "A0A6I8RDE5", "ENSXETG00000009413", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328682": { "compartment": "compartment_7660", "id": "reaction_10328682", "reactome": "R-XTR-4570553", "name": "SUMOylation of MDC1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328677", "species_10328443" ], "products": [ "species_10327128", "species_10328680" ], "modifiers": [ [ "species_10328443", "catalyst" ] ], "additional_components": [ "ENSXETG00000039209", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462", "ENSXETT00000054232", "ENSXETG00000039209", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462" ] }, "reaction_10328644": { "compartment": "compartment_7660", "id": "reaction_10328644", "reactome": "R-XTR-4568914", "name": "SUMOylation of BLM with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328443", "species_10328636" ], "products": [ "species_10328642", "species_10327128" ], "modifiers": [ [ "species_10328443", "catalyst" ] ], "additional_components": [ "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462", "ENSXETG00000007847", "ENSXETG00000007847", "ENSXETT00000054232", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462" ] }, "reaction_10328692": { "compartment": "compartment_7660", "id": "reaction_10328692", "reactome": "R-XTR-4570554", "name": "SUMOylation of MDC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328677" ], "products": [ "species_10328690", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000039209", "Q6DEP7", "ENSXETG00000022072", "A0A6I8SUQ0", "ENSXETG00000039209", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10327201": { "compartment": "compartment_7660", "id": "reaction_10327201", "reactome": "R-XTR-3000383", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10327188" ], "products": [ "species_10327128", "species_10327198" ], "modifiers": [ [ "species_10327128", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000039978", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "A0A6I8SBS8", "ENSXETG00000039978", "ENSXETT00000054232" ] }, "reaction_10328673": { "compartment": "compartment_7660", "id": "reaction_10328673", "reactome": "R-XTR-4570528", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328663" ], "products": [ "species_10327128", "species_10328671" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000033244", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "A0A6I8PUF7", "ENSXETG00000033244", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328579": { "compartment": "compartment_7660", "id": "reaction_10328579", "reactome": "R-XTR-4551616", "name": "SUMOylation of RPA1 (RPA70) with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328443", "species_10311307" ], "products": [ "species_10328576", "species_10327128" ], "modifiers": [ [ "species_10328443", "catalyst" ] ], "additional_components": [ "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462", "ENSXETG00000013538", "ENSXETG00000013538", "ENSXETT00000054232", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "Q6DK72", "ENSXETT00000062462" ] }, "reaction_10328649": { "compartment": "compartment_7660", "id": "reaction_10328649", "reactome": "R-XTR-4570485", "name": "SUMOylation of Histone H4 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313794", "species_10327222" ], "products": [ "species_10328647", "species_10327128" ], "modifiers": [ [ "species_10327222", "catalyst" ] ], "additional_components": [ "ENSXETG00000035354", "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000035354", "ENSXETT00000054232", "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328739": { "compartment": "compartment_7660", "id": "reaction_10328739", "reactome": "R-XTR-4616015", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328729" ], "products": [ "species_10328737", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETT00000023583", "Q6DEP7", "ENSXETG00000022072", "F6QFY1", "ENSXETT00000023583", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328659": { "compartment": "compartment_7660", "id": "reaction_10328659", "reactome": "R-XTR-4570496", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313794", "species_10327136" ], "products": [ "species_10328657", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "ENSXETG00000035354", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "A0A6I8RKR7", "ENSXETG00000035354", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328722": { "compartment": "compartment_7660", "id": "reaction_10328722", "reactome": "R-XTR-4615889", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10321877" ], "products": [ "species_10328720", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000005253", "A0A6I8SGY5", "ENSXETG00000005253", "Q6DEP7", "ENSXETG00000022072", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328845": { "compartment": "compartment_7660", "id": "reaction_10328845", "reactome": "R-XTR-4719436", "name": "PIAS2,3,4 SUMOylate RORA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10317102" ], "products": [ "species_10328843", "species_10327128" ], "modifiers": [ [ "species_10328832", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000021123", "Q6DEP7", "ENSXETG00000022072", "A0A6I8QBV8", "ENSXETG00000021123", "ENSXETT00000054232", "A0A6I8Q277", "ENSXETG00000021519", "A0A6I8S7F8", "ENSXETG00000018642" ] }, "reaction_10328572": { "compartment": "compartment_7660", "id": "reaction_10328572", "reactome": "R-XTR-4546386", "name": "PIAS1,3 SUMOylates NR5A1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10317110" ], "products": [ "species_10328570", "species_10327128" ], "modifiers": [ [ "species_10328492", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETT00000025024", "F7EHW3", "ENSXETT00000025024", "Q6DEP7", "ENSXETG00000022072", "ENSXETT00000054232", "ENSXETG00000018642" ] }, "reaction_10328511": { "compartment": "compartment_7660", "id": "reaction_10328511", "reactome": "R-XTR-4090390", "name": "PIAS1,2-1 SUMOylates AR with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10317088" ], "products": [ "species_10327128", "species_10328504" ], "modifiers": [ [ "species_10328508", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000005089", "ENSXETT00000054232", "A0A6I8RK73", "ENSXETG00000005089", "Q6DEP7", "ENSXETG00000022072", "ENSXETG00000021519" ] }, "reaction_10328942": { "compartment": "compartment_7660", "id": "reaction_10328942", "reactome": "R-XTR-4755494", "name": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328932" ], "products": [ "species_10327128", "species_10328940" ], "modifiers": [ [ "species_10328508", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "CHEBI:77361", "F7EHW3", "ENSXETT00000025024", "ENSXETT00000054232", "CHEBI:77361", "F7EHW3", "ENSXETT00000025024", "Q6DEP7", "ENSXETG00000022072", "ENSXETG00000021519" ] }, "reaction_10328536": { "compartment": "compartment_7660", "id": "reaction_10328536", "reactome": "R-XTR-4341025", "name": "SUMOylation of NR3C1 (GR) with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328523" ], "products": [ "species_10328534", "species_10327128" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "A0A6I8S149", "ENSXETG00000040373", "Q6DEP7", "ENSXETG00000022072", "A0A6I8S149", "ENSXETG00000040373", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10328548": { "compartment": "compartment_7660", "id": "reaction_10328548", "reactome": "R-XTR-4341073", "name": "PIAS3 SUMOylates PGR with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317074", "species_10327136" ], "products": [ "species_10328546", "species_10327128" ], "modifiers": [ [ "species_10328492", "catalyst" ] ], "additional_components": [ "ENSXETT00000040897", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "F6SI83", "ENSXETT00000040897", "ENSXETT00000054232", "ENSXETG00000018642" ] }, "reaction_10328951": { "compartment": "compartment_7660", "id": "reaction_10328951", "reactome": "R-XTR-4755524", "name": "SUMOylation of NR1I2 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328944", "species_10327222" ], "products": [ "species_10328949", "species_10327128" ], "modifiers": [], "additional_components": [ "A0A6I8RH34", "ENSXETG00000031759", "CHEBI:28077", "Q6DK72", "ENSXETT00000062462", "Q28CQ4", "ENSXETT00000054232", "CHEBI:28077", "A0A6I8RH34", "ENSXETG00000031759", "ENSXETT00000054232" ] }, "reaction_10328561": { "compartment": "compartment_7660", "id": "reaction_10328561", "reactome": "R-XTR-4546385", "name": "PIAS1,3 SUMOylates NR5A1 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317110", "species_10327209" ], "products": [ "species_10327128", "species_10328559" ], "modifiers": [ [ "species_10328492", "catalyst" ] ], "additional_components": [ "ENSXETT00000025024", "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "ENSXETT00000054232", "ENSXETT00000025024", "ENSXETG00000018642" ] }, "reaction_10328835": { "compartment": "compartment_7660", "id": "reaction_10328835", "reactome": "R-XTR-4719413", "name": "PIAS2,3,4 SUMOylate RORA with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327209", "species_10317102" ], "products": [ "species_10327128", "species_10328830" ], "modifiers": [ [ "species_10328832", "catalyst" ] ], "additional_components": [ "Q28CQ4", "ENSXETT00000054232", "Q28H04", "ENSXETT00000027383", "ENSXETG00000021123", "ENSXETT00000054232", "ENSXETG00000021123", "A0A6I8Q277", "ENSXETG00000021519", "A0A6I8S7F8", "ENSXETG00000018642" ] }, "reaction_10328495": { "compartment": "compartment_7660", "id": "reaction_10328495", "reactome": "R-XTR-4090288", "name": "PIAS1,3 SUMOylate MBD1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328479" ], "products": [ "species_10327128", "species_10328488" ], "modifiers": [ [ "species_10328492", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETG00000040845", "ENSXETT00000054232", "A0A6I8RGR4", "ENSXETG00000040845", "Q6DEP7", "ENSXETG00000022072", "ENSXETG00000018642" ] }, "reaction_10328219": { "compartment": "compartment_7660", "id": "reaction_10328219", "reactome": "R-XTR-3782535", "name": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328201" ], "products": [ "species_10327128", "species_10328216" ], "modifiers": [ [ "species_10320733", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "A0A6I8QJW7", "ENSXETG00000019245", "A0A6I8RRG3", "ENSXETG00000040574", "A0A6I8RGG7", "ENSXETG00000035980", "ENSXETT00000054232", "A0A6I8RRG3", "ENSXETG00000040574", "A0A6I8RGG7", "ENSXETG00000035980", "Q6DEP7", "ENSXETG00000022072", "A0A6I8QJW7", "ENSXETG00000019245", "ENSXETG00000019245" ] }, "reaction_10328336": { "compartment": "compartment_7660", "id": "reaction_10328336", "reactome": "R-XTR-3900177", "name": "SUMOylation of DDX5 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327136", "species_10328325" ], "products": [ "species_10327128", "species_10328333" ], "modifiers": [ [ "species_10327136", "catalyst" ] ], "additional_components": [ "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "ENSXETT00000044525", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "F7CZ58", "ENSXETT00000044525", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232" ] }, "reaction_10337527": { "compartment": "compartment_7660", "id": "reaction_10337527", "reactome": "R-XTR-9023860", "name": "Histone acetyltransferases are recruited to the TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337523", "species_10337509" ], "products": [ "species_10337525" ], "modifiers": [], "additional_components": [ "Q6DEQ4", "ENSXETT00000056546", "Q28GG8", "ENSXETT00000018725", "L7N2Q7", "ENSXETT00000009600", "Q8AWH1", "ENSXETG00000025867", "CHEBI:142773", "species_193066", "species_193132", "CHEBI:27974", "F7CZ58", "ENSXETT00000044525", "Q28F07", "ENSXETT00000094658", "ENSXETG00000041035", "A0A6I8SAY5", "ENSXETG00000041035", "Q6DEQ4", "ENSXETT00000056546", "Q28GG8", "ENSXETT00000018725", "L7N2Q7", "ENSXETT00000009600", "Q8AWH1", "ENSXETG00000025867", "CHEBI:142773", "species_193066", "species_193132", "CHEBI:27974", "F7CZ58", "ENSXETT00000044525", "Q28F07", "ENSXETT00000094658" ] }, "reaction_10317879": { "compartment": "compartment_984", "id": "reaction_10317879", "reactome": "R-XTR-420489", "name": "Parathyroid hormone receptor can bind parathyroid hormone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317875", "species_10317871" ], "products": [ "species_10317877" ], "modifiers": [], "additional_components": [ "ENSXETG00000037389", "Q5G7I8", "ENSXETT00000000004", "F6UDH6", "ENSXETT00000022720", "Q5G7I8", "ENSXETT00000000004", "F6UDH6", "ENSXETT00000022720", "A0A6I8QXF2", "ENSXETG00000037389" ] }, "reaction_10318448": { "compartment": "compartment_984", "id": "reaction_10318448", "reactome": "R-XTR-444773", "name": "EGF-TM7 receptors bind chondroitin sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444761", "species_10318444" ], "products": [ "species_10318446" ], "modifiers": [], "additional_components": [ "F6WSE4", "ENSXETT00000003359", "F6WSE4", "ENSXETT00000003359", "species_444761" ] }, "reaction_10317843": { "compartment": "compartment_984", "id": "reaction_10317843", "reactome": "R-XTR-420214", "name": "The adrenomedullin receptor can bind adrenomedullin and intermedin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317829", "species_10317839" ], "products": [ "species_10317841" ], "modifiers": [], "additional_components": [ "A0A6I8SCW9", "ENSXETG00000040245", "A0A6I8REF2", "ENSXETG00000034576", "A0A6I8QAL9", "ENSXETG00000035598", "Q0P4Y4", "ENSXETT00000074242", "A0A6I8QAL9", "ENSXETG00000035598", "Q0P4Y4", "ENSXETT00000074242", "A0A6I8SCW9", "ENSXETG00000040245", "A0A6I8REF2", "ENSXETG00000034576" ] }, "reaction_10317901": { "compartment": "compartment_984", "id": "reaction_10317901", "reactome": "R-XTR-420739", "name": "GPRC6A can bind L-alpha amino acids and calcium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_420706", "species_10317897" ], "products": [ "species_10317899" ], "modifiers": [], "additional_components": [ "species_74112", "CHEBI:32551", "species_29468", "species_29498", "ENSXETG00000032935", "A0A6I8PQL7", "ENSXETG00000032935", "species_74112", "CHEBI:32551", "species_29468", "species_29498" ] }, "reaction_10327557": { "compartment": "compartment_876", "id": "reaction_10327557", "reactome": "R-XTR-3296233", "name": "T2Rs bind bitter-tasting compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320034", "species_3296423" ], "products": [ "species_10320036" ], "modifiers": [], "additional_components": [ "Q2AB79", "ENSXETT00000093107", "Q2AB72", "ENSXETT00000061687", "Q2AB77", "ENSXETT00000063907", "Q2AB63", "ENSXETT00000061269", "Q2AB68", "ENSXETT00000060826", "Q2AB52", "ENSXETT00000063621", "Q2AB53", "ENSXETT00000018688", "Q2AB48", "ENSXETT00000065249", "Q2AB51", "ENSXETT00000063088", "Q2AB44", "ENSXETT00000066089", "Q2AB45", "ENSXETT00000079130", "Q2AB41", "ENSXETT00000061480", "Q2AB42", "ENSXETT00000065552", "Q2AB38", "ENSXETT00000033481", "Q2AB39", "ENSXETT00000082983", "Q2AB34", "ENSXETT00000060343", "Q2AB35", "ENSXETT00000062616", "A0A6I8RXG4", "ENSXETG00000036502", "A0A6I8S8Y1", "ENSXETG00000038186", "A0A6I8Q8V5", "ENSXETG00000035342", "A0A6I8R2L9", "ENSXETG00000036502", "A0A6I8PTF7", "ENSXETG00000036502", "A0A6I8Q288", "ENSXETG00000031892", "A0A6I8PS37", "ENSXETG00000032405", "A0A6I8PSM4", "ENSXETG00000008531", "A0A6I8PK15", "ENSXETG00000027471", "A0A6I8PQY6", "ENSXETG00000040729", "A0A6I8PJF9", "ENSXETG00000040152", "CHEBI:3193", "species_76328", "CHEBI:3768", "CHEBI:10093", "CHEBI:17814", "species_40727", "CHEBI:8206", "CHEBI:48923", "CHEBI:28973", "CHEBI:73228", "CHEBI:23359", "CHEBI:28241", "CHEBI:73226", "CHEBI:73224", "CHEBI:65408", "CHEBI:3944", "CHEBI:73235", "CHEBI:73231", "CHEBI:16226", "CHEBI:27613", "CHEBI:5547", "CHEBI:2825", "CHEBI:73232", "CHEBI:18305", "CHEBI:3445", "CHEBI:36773", "CHEBI:2622", "CHEBI:73237", "CHEBI:2366", "CHEBI:3941", "CHEBI:7939", "CHEBI:351346", "CHEBI:8692", "CHEBI:73239", "CHEBI:15854", "CHEBI:9162", "CHEBI:26948", "CHEBI:50042", "CHEBI:69236", "CHEBI:73222", "CHEBI:17698", "CHEBI:73236", "CHEBI:2853", "CHEBI:3193", "species_76328", "CHEBI:3768", "CHEBI:10093", "CHEBI:17814", "species_40727", "CHEBI:8206", "CHEBI:48923", "CHEBI:28973", "CHEBI:73228", "CHEBI:23359", "CHEBI:28241", "CHEBI:73226", "CHEBI:73224", "CHEBI:65408", "CHEBI:3944", "CHEBI:73235", "CHEBI:73231", "CHEBI:16226", "CHEBI:27613", "CHEBI:5547", "CHEBI:2825", "CHEBI:73232", "CHEBI:18305", "CHEBI:3445", "CHEBI:36773", "CHEBI:2622", "CHEBI:73237", "CHEBI:2366", "CHEBI:3941", "CHEBI:7939", "CHEBI:351346", "CHEBI:8692", "CHEBI:73239", "CHEBI:15854", "CHEBI:9162", "CHEBI:26948", "CHEBI:50042", "CHEBI:69236", "CHEBI:73222", "CHEBI:17698", "CHEBI:73236", "CHEBI:2853", "Q2AB79", "ENSXETT00000093107", "Q2AB72", "ENSXETT00000061687", "Q2AB77", "ENSXETT00000063907", "Q2AB63", "ENSXETT00000061269", "Q2AB68", "ENSXETT00000060826", "Q2AB52", "ENSXETT00000063621", "Q2AB53", "ENSXETT00000018688", "Q2AB48", "ENSXETT00000065249", "Q2AB51", "ENSXETT00000063088", "Q2AB44", "ENSXETT00000066089", "Q2AB45", "ENSXETT00000079130", "Q2AB41", "ENSXETT00000061480", "Q2AB42", "ENSXETT00000065552", "Q2AB38", "ENSXETT00000033481", "Q2AB39", "ENSXETT00000082983", "Q2AB34", "ENSXETT00000060343", "Q2AB35", "ENSXETT00000062616", "A0A6I8RXG4", "ENSXETG00000036502", "A0A6I8S8Y1", "ENSXETG00000038186", "A0A6I8Q8V5", "ENSXETG00000035342", "A0A6I8R2L9", "ENSXETG00000036502", "A0A6I8PTF7", "ENSXETG00000036502", "A0A6I8Q288", "ENSXETG00000031892", "A0A6I8PS37", "ENSXETG00000032405", "A0A6I8PSM4", "ENSXETG00000008531", "A0A6I8PK15", "ENSXETG00000027471", "A0A6I8PQY6", "ENSXETG00000040729", "A0A6I8PJF9", "ENSXETG00000040152" ] }, "reaction_10316852": { "compartment": "compartment_984", "id": "reaction_10316852", "reactome": "R-XTR-373075", "name": "Metabotropic glutamate receptors bind glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316848", "species_210382" ], "products": [ "species_10316850" ], "modifiers": [], "additional_components": [ "ENSXETG00000006732", "species_210382", "A0A6I8RDQ8", "ENSXETG00000006732" ] }, "reaction_10317446": { "compartment": "compartment_984", "id": "reaction_10317446", "reactome": "R-XTR-390835", "name": "DRD1,5 bind DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317442", "species_380873" ], "products": [ "species_10317444" ], "modifiers": [], "additional_components": [ "ENSXETG00000026496", "species_351601", "A0A6I8PSM8", "ENSXETG00000026496" ] }, "reaction_10317454": { "compartment": "compartment_984", "id": "reaction_10317454", "reactome": "R-XTR-390909", "name": "HRH2 binds hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317450", "species_390899" ], "products": [ "species_10317452" ], "modifiers": [], "additional_components": [ "ENSXETG00000029997", "species_390899", "A0A6I8Q5E3", "ENSXETG00000029997" ] }, "reaction_10317462": { "compartment": "compartment_984", "id": "reaction_10317462", "reactome": "R-XTR-390912", "name": "HRH1 binds hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317458", "species_390899" ], "products": [ "species_10317460" ], "modifiers": [], "additional_components": [ "ENSXETG00000007717", "species_390899", "A0A6I8QYI9", "ENSXETG00000007717" ] }, "reaction_10317438": { "compartment": "compartment_984", "id": "reaction_10317438", "reactome": "R-XTR-390649", "name": "CHRM1,3,5 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317434", "species_372533" ], "products": [ "species_10317436" ], "modifiers": [], "additional_components": [ "A0A6I8PJ30", "ENSXETG00000017868", "A0A6I8SRX2", "ENSXETG00000037602", "species_372533", "A0A6I8PJ30", "ENSXETG00000017868", "A0A6I8SRX2", "ENSXETG00000037602" ] }, "reaction_10337759": { "compartment": "compartment_984", "id": "reaction_10337759", "reactome": "R-XTR-9611839", "name": "3-agonists bind ADRB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9611836", "species_10319102" ], "products": [ "species_10337757" ], "modifiers": [], "additional_components": [ "ENSXETG00000030790", "A0A6I8PZ77", "ENSXETG00000030790" ] }, "reaction_10317422": { "compartment": "compartment_984", "id": "reaction_10317422", "reactome": "R-XTR-390641", "name": "ADRA1A,B,D bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317414", "species_390627" ], "products": [ "species_10317416" ], "modifiers": [ [ "species_10317420", "catalyst" ], [ "species_10317418", "inhibitor" ] ], "additional_components": [ "F6SBD0", "ENSXETT00000037826", "A0A6I8RMZ6", "ENSXETG00000035197", "CHEBI:28918", "CHEBI:18357", "CHEBI:28918", "CHEBI:18357", "F6SBD0", "ENSXETT00000037826", "A0A6I8RMZ6", "ENSXETG00000035197", "F6SBD0", "ENSXETT00000037826", "A0A6I8RMZ6", "ENSXETG00000035197", "F6SBD0", "ENSXETT00000037826", "A0A6I8RMZ6", "ENSXETG00000035197" ] }, "reaction_10337755": { "compartment": "compartment_984", "id": "reaction_10337755", "reactome": "R-XTR-9609310", "name": "-blockers bind ADRB1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9609307", "species_10319102" ], "products": [ "species_10337753" ], "modifiers": [], "additional_components": [ "ENSXETG00000030790", "A0A6I8PZ77", "ENSXETG00000030790" ] }, "reaction_10337761": { "compartment": "compartment_984", "id": "reaction_10337761", "reactome": "R-XTR-9611852", "name": "ADRB3 bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10319102" ], "products": [ "species_10319104" ], "modifiers": [ [ "species_10337757", "catalyst" ], [ "species_10337753", "inhibitor" ] ], "additional_components": [ "CHEBI:28918", "CHEBI:18357", "ENSXETG00000030790", "A0A6I8PZ77", "ENSXETG00000030790", "CHEBI:28918", "CHEBI:18357", "A0A6I8PZ77", "ENSXETG00000030790", "A0A6I8PZ77", "ENSXETG00000030790" ] }, "reaction_10317574": { "compartment": "compartment_984", "id": "reaction_10317574", "reactome": "R-XTR-391211", "name": "Trace amine-associated receptors can bind trace amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317570", "species_391200" ], "products": [ "species_10317572" ], "modifiers": [], "additional_components": [ "A0A6I8RAX0", "ENSXETG00000039183", "species_391200", "A0A6I8RAX0", "ENSXETG00000039183" ] }, "reaction_10317480": { "compartment": "compartment_984", "id": "reaction_10317480", "reactome": "R-XTR-390929", "name": "HTR1 and 5A receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10317476" ], "products": [ "species_10317478" ], "modifiers": [], "additional_components": [ "A0A6I8R5Z0", "ENSXETG00000038202", "A0A6I8QW91", "ENSXETG00000040924", "A0A6I8QWR5", "ENSXETG00000036447", "A0A6I8R5Z0", "ENSXETG00000038202", "A0A6I8QW91", "ENSXETG00000040924", "A0A6I8QWR5", "ENSXETG00000036447", "species_114523" ] }, "reaction_10317496": { "compartment": "compartment_984", "id": "reaction_10317496", "reactome": "R-XTR-390931", "name": "5-HT4, 6 and 7 receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10317492" ], "products": [ "species_10317494" ], "modifiers": [], "additional_components": [ "ENSXETG00000031961", "A0A6I8PXU4", "ENSXETG00000031961", "species_114523" ] }, "reaction_10338203": { "compartment": "compartment_984", "id": "reaction_10338203", "reactome": "R-XTR-9693347", "name": "HTR1A binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338199", "species_114523" ], "products": [ "species_10338201" ], "modifiers": [], "additional_components": [ "ENSXETT00000025697", "species_114523", "F7CKP0", "ENSXETT00000025697" ] }, "reaction_10317488": { "compartment": "compartment_984", "id": "reaction_10317488", "reactome": "R-XTR-390930", "name": "5-HT2 receptor can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10317484" ], "products": [ "species_10317486" ], "modifiers": [], "additional_components": [ "ENSXETT00000009523", "F7D3H9", "ENSXETT00000009523", "species_114523" ] }, "reaction_10334962": { "compartment": "compartment_876", "id": "reaction_10334962", "reactome": "R-XTR-8851298", "name": "GPR143 binds L-Dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10319146", "species_8851314" ], "products": [ "species_10319148" ], "modifiers": [], "additional_components": [ "ENSXETT00000044971", "species_8851314", "F6TV02", "ENSXETT00000044971" ] }, "reaction_10334041": { "compartment": "compartment_984", "id": "reaction_10334041", "reactome": "R-XTR-6805205", "name": "GPR35 binds kynurenic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334037", "species_6805204" ], "products": [ "species_10334039" ], "modifiers": [], "additional_components": [ "ENSXETG00000032766", "species_6805204", "A0A6I8PMC3", "ENSXETG00000032766" ] }, "reaction_10318999": { "compartment": "compartment_984", "id": "reaction_10318999", "reactome": "R-XTR-517536", "name": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318995", "species_517533" ], "products": [ "species_10318997" ], "modifiers": [], "additional_components": [ "ENSXETG00000032224", "species_517533", "A0A6I8Q5A1", "ENSXETG00000032224" ] }, "reaction_10318398": { "compartment": "compartment_984", "id": "reaction_10318398", "reactome": "R-XTR-444527", "name": "FPR is a receptor for formyl peptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318394", "species_444519" ], "products": [ "species_10318396" ], "modifiers": [], "additional_components": [ "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8Q632", "ENSXETG00000041332", "species_444519", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8SM80", "ENSXETG00000041332", "A0A6I8Q632", "ENSXETG00000041332" ] }, "reaction_10318384": { "compartment": "compartment_984", "id": "reaction_10318384", "reactome": "R-XTR-444476", "name": "FPRL2 receptor binds a wide range of ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318376", "species_10318380" ], "products": [ "species_10318382" ], "modifiers": [], "additional_components": [ "A0A6I8Q632", "ENSXETG00000041332", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8SM80", "ENSXETG00000041332", "ENSXETT00000057031", "Q6DJ66", "ENSXETT00000057031", "A0A6I8Q632", "ENSXETG00000041332", "A0A6I8SWF4", "ENSXETG00000041332", "A0A6I8Q814", "ENSXETG00000041332", "A0A6I8SM80", "ENSXETG00000041332" ] }, "reaction_10317308": { "compartment": "compartment_984", "id": "reaction_10317308", "reactome": "R-XTR-388560", "name": "Endothelin receptors bind endothelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317300", "species_10317304" ], "products": [ "species_10317306" ], "modifiers": [], "additional_components": [ "ENSXETG00000041205", "ENSXETT00000033726", "F6RQM0", "ENSXETT00000033726", "A0A6I8QC71", "ENSXETG00000041205" ] }, "reaction_10316908": { "compartment": "compartment_984", "id": "reaction_10316908", "reactome": "R-XTR-373791", "name": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316886", "species_10316904" ], "products": [ "species_10316906" ], "modifiers": [], "additional_components": [ "F6XNR7", "ENSXETT00000034054", "A0A6I8T2T2", "ENSXETG00000036062", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8QDT0", "ENSXETG00000039678", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8QDT0", "ENSXETG00000039678", "F6XNR7", "ENSXETT00000034054", "A0A6I8T2T2", "ENSXETG00000036062" ] }, "reaction_10318316": { "compartment": "compartment_984", "id": "reaction_10318316", "reactome": "R-XTR-443986", "name": "Receptor ACKR2 binds most inflammatory CC chemokines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318292", "species_10318312" ], "products": [ "species_10318314" ], "modifiers": [], "additional_components": [ "ENSXETT00000003445", "A0A6I8SVN2", "ENSXETG00000037100", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "F7C531", "ENSXETT00000003445" ] }, "reaction_10316975": { "compartment": "compartment_984", "id": "reaction_10316975", "reactome": "R-XTR-374214", "name": "Receptors CXCR4 and 7 bind CXCL12 ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316967", "species_10316971" ], "products": [ "species_10316973" ], "modifiers": [], "additional_components": [ "ENSXETT00000032559", "ENSXETT00000068483", "Q5EBF6", "ENSXETT00000068483", "Q07FZ4", "ENSXETT00000032559" ] }, "reaction_10316942": { "compartment": "compartment_984", "id": "reaction_10316942", "reactome": "R-XTR-373813", "name": "Receptor CXCR2 binds ligands CXCL1 to 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316938", "species_10316910" ], "products": [ "species_10316940" ], "modifiers": [], "additional_components": [ "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8QDT0", "ENSXETG00000039678", "ENSXETG00000036062", "A0A6I8T2T2", "ENSXETG00000036062", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8QDT0", "ENSXETG00000039678" ] }, "reaction_10316872": { "compartment": "compartment_876", "id": "reaction_10316872", "reactome": "R-XTR-373342", "name": "CX3CR1 binds CX3CL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316818", "species_10316868" ], "products": [ "species_10316870" ], "modifiers": [], "additional_components": [ "A0A6I8R4J8", "ENSXETG00000041335", "F6RFH7", "ENSXETT00000046189", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8R4J8", "ENSXETG00000041335", "F6RFH7", "ENSXETT00000046189" ] }, "reaction_10335627": { "compartment": "compartment_984", "id": "reaction_10335627", "reactome": "R-XTR-8862733", "name": "CCR2, CCR3 bind CCL13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320058", "species_10320060" ], "products": [ "species_10320062" ], "modifiers": [], "additional_components": [ "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "F6RFH7", "ENSXETT00000046189", "A0A6I8R4J8", "ENSXETG00000041335", "F6RFH7", "ENSXETT00000046189", "A0A6I8R4J8", "ENSXETG00000041335", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100" ] }, "reaction_10316836": { "compartment": "compartment_984", "id": "reaction_10316836", "reactome": "R-XTR-373061", "name": "Receptors CCR3, 4 and 5 bind CCL5 ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316832", "species_10316808" ], "products": [ "species_10316834" ], "modifiers": [], "additional_components": [ "F6RFH7", "ENSXETT00000046189", "A0A6I8R4J8", "ENSXETG00000041335", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "F6RFH7", "ENSXETT00000046189", "A0A6I8R4J8", "ENSXETG00000041335" ] }, "reaction_10334964": { "compartment": "compartment_876", "id": "reaction_10334964", "reactome": "R-XTR-8851352", "name": "CCR8 binds CCL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320070", "species_10316812" ], "products": [ "species_10320072" ], "modifiers": [], "additional_components": [ "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100", "ENSXETG00000041335", "A0A6I8R4J8", "ENSXETG00000041335", "A0A6I8SYD2", "ENSXETG00000036196", "A0A6I8SI97", "ENSXETG00000036196", "A0A6I8SVN2", "ENSXETG00000037100" ] }, "reaction_10317326": { "compartment": "compartment_984", "id": "reaction_10317326", "reactome": "R-XTR-388900", "name": "Neurotensin receptors can bind neurotensins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317316", "species_10317320" ], "products": [ "species_10317324" ], "modifiers": [], "additional_components": [ "ENSXETG00000040562", "ENSXETG00000037844", "A0A6I8S4R6", "ENSXETG00000037844", "A0A6I8QBR7", "ENSXETG00000040562" ] }, "reaction_10317048": { "compartment": "compartment_984", "id": "reaction_10317048", "reactome": "R-XTR-375384", "name": "Bombesin-like receptors bind bombesin homologues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317040", "species_10317044" ], "products": [ "species_10317046" ], "modifiers": [], "additional_components": [ "ENSXETT00000045737", "ENSXETG00000030584", "A0A6I8Q016", "ENSXETG00000030584", "F7CE29", "ENSXETT00000045737" ] }, "reaction_10337771": { "compartment": "compartment_984", "id": "reaction_10337771", "reactome": "R-XTR-9615249", "name": "ARBs bind AGRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316946", "species_9615246" ], "products": [ "species_10316960" ], "modifiers": [], "additional_components": [ "ENSXETT00000023026", "B3DLC0", "ENSXETT00000023026" ] }, "reaction_10318464": { "compartment": "compartment_984", "id": "reaction_10318464", "reactome": "R-XTR-444848", "name": "Relaxin 3 receptor 1 binds relaxin 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318452", "species_10318460" ], "products": [ "species_10318462" ], "modifiers": [], "additional_components": [ "ENSXETT00000037509", "B1AAQ2", "ENSXETT00000062741", "B1AAQ2", "ENSXETT00000062741", "F7E376", "ENSXETT00000037509" ] }, "reaction_10318480": { "compartment": "compartment_984", "id": "reaction_10318480", "reactome": "R-XTR-444859", "name": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318466", "species_10318476" ], "products": [ "species_10318478" ], "modifiers": [], "additional_components": [ "ENSXETT00000037509", "B1AAQ2", "ENSXETT00000062741", "A0A6I8SQK1", "ENSXETG00000036496", "B1AAQ2", "ENSXETT00000062741", "A0A6I8SQK1", "ENSXETG00000036496", "F7E376", "ENSXETT00000037509" ] }, "reaction_10317344": { "compartment": "compartment_984", "id": "reaction_10317344", "reactome": "R-XTR-389487", "name": "Orexin 2 receptor can bind orexin-B neuropeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317336", "species_10317340" ], "products": [ "species_10317342" ], "modifiers": [], "additional_components": [ "ENSXETG00000036925", "ENSXETT00000034321", "F6UHP0", "ENSXETT00000034321", "A0A6I8RRB4", "ENSXETG00000036925" ] }, "reaction_10316962": { "compartment": "compartment_984", "id": "reaction_10316962", "reactome": "R-XTR-374173", "name": "AGT(34-41) binds to AGTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316946", "species_10316956" ], "products": [ "species_10316958" ], "modifiers": [ [ "species_10316960", "inhibitor" ] ], "additional_components": [ "ENSXETT00000023026", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "B3DLC0", "ENSXETT00000023026", "B3DLC0", "ENSXETT00000023026" ] }, "reaction_10320722": { "compartment": "compartment_876", "id": "reaction_10320722", "reactome": "R-XTR-947673", "name": "Melanin-concentrating hormone receptors bind MCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10319136", "species_10319140" ], "products": [ "species_10319142" ], "modifiers": [], "additional_components": [ "ENSXETT00000065305", "ENSXETG00000030934", "A0A6I8PX40", "ENSXETG00000030934", "F6YI59", "ENSXETT00000065305" ] }, "reaction_10317817": { "compartment": "compartment_984", "id": "reaction_10317817", "reactome": "R-XTR-419428", "name": "S1PR2-5 bind S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_10317813" ], "products": [ "species_10317815" ], "modifiers": [], "additional_components": [ "A0A6I8PRW9", "ENSXETG00000033700", "B1WAQ2", "ENSXETT00000070659", "A0A6I8PRW9", "ENSXETG00000033700", "B1WAQ2", "ENSXETT00000070659", "species_428203" ] }, "reaction_10317803": { "compartment": "compartment_984", "id": "reaction_10317803", "reactome": "R-XTR-419389", "name": "LPA-binding receptors bind LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317799", "species_417891" ], "products": [ "species_10317801" ], "modifiers": [], "additional_components": [ "ENSXETG00000039332", "species_417891", "A0A6I8RG49", "ENSXETG00000039332" ] }, "reaction_10318412": { "compartment": "compartment_984", "id": "reaction_10318412", "reactome": "R-XTR-444661", "name": "HCAR2 binds HCAR2 ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318408", "species_3296262" ], "products": [ "species_10318410" ], "modifiers": [], "additional_components": [ "ENSXETG00000033184", "CHEBI:20067", "CHEBI:15940", "CHEBI:20067", "CHEBI:15940", "A0A6I8PVP2", "ENSXETG00000033184" ] }, "reaction_10317756": { "compartment": "compartment_984", "id": "reaction_10317756", "reactome": "R-XTR-418918", "name": "The UDP/CysLT (P2Y17) receptor can bind UTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_417888", "species_10317614" ], "products": [ "species_10317754" ], "modifiers": [], "additional_components": [ "ENSXETG00000030217", "A0A6I8Q294", "ENSXETG00000030217", "species_417888" ] }, "reaction_10317705": { "compartment": "compartment_984", "id": "reaction_10317705", "reactome": "R-XTR-417927", "name": "P2Y2 receptor binds ATP and UTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317701", "species_511955" ], "products": [ "species_10317703" ], "modifiers": [], "additional_components": [ "ENSXETG00000039207", "CHEBI:15713", "species_113593", "CHEBI:15713", "species_113593", "A0A6I8T2N1", "ENSXETG00000039207" ] }, "reaction_10317752": { "compartment": "compartment_984", "id": "reaction_10317752", "reactome": "R-XTR-418904", "name": "A1 and A3 receptors bind adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317746", "species_83908" ], "products": [ "species_10317750" ], "modifiers": [], "additional_components": [ "ENSXETG00000031634", "species_8857850", "A0A6I8QZP2", "ENSXETG00000031634" ] }, "reaction_10327569": { "compartment": "compartment_876", "id": "reaction_10327569", "reactome": "R-XTR-3296309", "name": "HCAR3 binds HCAR3 ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320048", "species_3296330" ], "products": [ "species_10320050" ], "modifiers": [], "additional_components": [ "ENSXETG00000033184", "CHEBI:37098", "CHEBI:15940", "CHEBI:37098", "CHEBI:15940", "A0A6I8PVP2", "ENSXETG00000033184" ] }, "reaction_10327571": { "compartment": "compartment_876", "id": "reaction_10327571", "reactome": "R-XTR-3296326", "name": "HCAR1 binds LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_373863", "species_10320044" ], "products": [ "species_10320046" ], "modifiers": [], "additional_components": [ "ENSXETG00000033184", "A0A6I8PVP2", "ENSXETG00000033184", "species_373863" ] }, "reaction_10327567": { "compartment": "compartment_876", "id": "reaction_10327567", "reactome": "R-XTR-3296304", "name": "GPR31 is a receptor for 12(S)-HETE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320086", "species_3296298" ], "products": [ "species_10320088" ], "modifiers": [], "additional_components": [ "ENSXETG00000033184", "species_3296298", "A0A6I8PVP2", "ENSXETG00000033184" ] }, "reaction_10318324": { "compartment": "compartment_984", "id": "reaction_10318324", "reactome": "R-XTR-444047", "name": "Receptor FFAR3 binds carboxylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318320", "species_444074" ], "products": [ "species_10318322" ], "modifiers": [], "additional_components": [ "ENSXETG00000034865", "species_29460", "CHEBI:31011", "species_76179", "species_29416", "CHEBI:30768", "species_29460", "CHEBI:31011", "species_76179", "species_29416", "CHEBI:30768", "A0A6I8RL92", "ENSXETG00000034865" ] }, "reaction_10318339": { "compartment": "compartment_984", "id": "reaction_10318339", "reactome": "R-XTR-444171", "name": "Receptor FFAR2 binds carboxylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444210", "species_10318335" ], "products": [ "species_10318337" ], "modifiers": [], "additional_components": [ "species_29460", "CHEBI:17120", "CHEBI:31011", "species_76179", "species_29416", "CHEBI:30768", "ENSXETG00000034865", "A0A6I8RL92", "ENSXETG00000034865", "species_29460", "CHEBI:17120", "CHEBI:31011", "species_76179", "species_29416", "CHEBI:30768" ] }, "reaction_10327559": { "compartment": "compartment_876", "id": "reaction_10327559", "reactome": "R-XTR-3296244", "name": "SUCNR1 binds SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433123", "species_10320040" ], "products": [ "species_10320042" ], "modifiers": [], "additional_components": [ "ENSXETG00000039349", "A0A6I8S407", "ENSXETG00000039349", "species_159939" ] }, "reaction_10318406": { "compartment": "compartment_984", "id": "reaction_10318406", "reactome": "R-XTR-444572", "name": "Zinc is an agonist of GPR39", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318402", "species_158417" ], "products": [ "species_10318404" ], "modifiers": [], "additional_components": [ "ENSXETG00000036628", "species_29426", "A0A6I8RPP0", "ENSXETG00000036628" ] }, "reaction_10318432": { "compartment": "compartment_984", "id": "reaction_10318432", "reactome": "R-XTR-444731", "name": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_10318428" ], "products": [ "species_10318430" ], "modifiers": [], "additional_components": [ "F7AA76", "ENSXETT00000034427", "A0A6I8QT77", "ENSXETG00000040511", "A0A6I8PUB9", "ENSXETG00000033328", "F7AA76", "ENSXETT00000034427", "A0A6I8QT77", "ENSXETG00000040511", "A0A6I8PUB9", "ENSXETG00000033328", "species_156540" ] }, "reaction_10317644": { "compartment": "compartment_984", "id": "reaction_10317644", "reactome": "R-XTR-391942", "name": "IP receptor can bind prostacyclin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317640", "species_391926" ], "products": [ "species_10317642" ], "modifiers": [], "additional_components": [ "ENSXETG00000031128", "species_31593", "A0A6I8PVP3", "ENSXETG00000031128" ] }, "reaction_10317610": { "compartment": "compartment_984", "id": "reaction_10317610", "reactome": "R-XTR-391934", "name": "DP2 receptor can bind PGD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317606", "species_416911" ], "products": [ "species_10317608" ], "modifiers": [], "additional_components": [ "A0A6I8PVU0", "ENSXETG00000035176", "A0A6I8QNA8", "ENSXETG00000036987", "A0A6I8QGG0", "ENSXETG00000035176", "species_416911", "A0A6I8PVU0", "ENSXETG00000035176", "A0A6I8QNA8", "ENSXETG00000036987", "A0A6I8QGG0", "ENSXETG00000035176" ] }, "reaction_10317697": { "compartment": "compartment_984", "id": "reaction_10317697", "reactome": "R-XTR-416929", "name": "FP receptor can bind PGF2-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_391928", "species_10317693" ], "products": [ "species_10317695" ], "modifiers": [], "additional_components": [ "ENSXETG00000036599", "A0A6I8S7J6", "ENSXETG00000036599", "species_391928" ] }, "reaction_10317588": { "compartment": "compartment_984", "id": "reaction_10317588", "reactome": "R-XTR-391905", "name": "Oxoeicosanoid receptor can bind oxoeicosanoid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317584", "species_416428" ], "products": [ "species_10317586" ], "modifiers": [], "additional_components": [ "ENSXETG00000033184", "species_416428", "A0A6I8PVP2", "ENSXETG00000033184" ] }, "reaction_10317636": { "compartment": "compartment_984", "id": "reaction_10317636", "reactome": "R-XTR-391941", "name": "BLT receptors can bind LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317632", "species_416436" ], "products": [ "species_10317634" ], "modifiers": [], "additional_components": [ "F7B9R6", "ENSXETT00000038060", "A0A6I8S269", "ENSXETG00000036845", "species_416436", "F7B9R6", "ENSXETT00000038060", "A0A6I8S269", "ENSXETG00000036845" ] }, "reaction_10317618": { "compartment": "compartment_984", "id": "reaction_10317618", "reactome": "R-XTR-391937", "name": "UDP/CysLT receptor can bind cysteinyl leukotrienes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317614", "species_416372" ], "products": [ "species_10317616" ], "modifiers": [], "additional_components": [ "ENSXETG00000030217", "CHEBI:28666", "CHEBI:16978", "CHEBI:15650", "CHEBI:28666", "CHEBI:16978", "CHEBI:15650", "A0A6I8Q294", "ENSXETG00000030217" ] }, "reaction_10317742": { "compartment": "compartment_876", "id": "reaction_10317742", "reactome": "R-XTR-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312731" ], "products": [ "species_10317739" ], "modifiers": [ [ "species_10312731", "catalyst" ] ], "additional_components": [ "B1H2U7", "ENSXETT00000094272", "species_29438", "species_29420", "B1H2U7", "ENSXETT00000094272", "B1H2U7", "ENSXETT00000094272", "species_29438" ] }, "reaction_10317795": { "compartment": "compartment_70101", "id": "reaction_10317795", "reactome": "R-XTR-419166", "name": "GEFs activate RhoA,B,C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10317687" ], "products": [ "species_29420", "species_10317689" ], "modifiers": [ [ "species_10316070", "catalyst" ] ], "additional_components": [ "species_29420", "Q6NVL3", "ENSXETT00000056231", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8QGS5", "ENSXETG00000038787", "F7DKF6", "ENSXETT00000044021", "A4II46", "ENSXETT00000074782", "A0A6I8Q734", "ENSXETG00000009131", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10312776": { "compartment": "compartment_114521", "id": "reaction_10312776", "reactome": "R-XTR-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10312773", "catalyst" ] ], "additional_components": [ "species_114520", "species_74112", "A0A6I8QV43", "ENSXETG00000005153", "F6XEN8", "ENSXETT00000003958" ] }, "reaction_10317957": { "compartment": "compartment_70101", "id": "reaction_10317957", "reactome": "R-XTR-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_76108", "species_29370" ], "modifiers": [ [ "species_10317954", "catalyst" ] ], "additional_components": [ "A0A6I8SXY7", "ENSXETG00000014560", "A0A6I8SPG5", "ENSXETG00000005053", "F7DCA2", "ENSXETT00000006488" ] }, "reaction_10312816": { "compartment": "compartment_70101", "id": "reaction_10312816", "reactome": "R-XTR-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312771", "species_114520" ], "products": [ "species_10312773" ], "modifiers": [], "additional_components": [ "A0A6I8QV43", "ENSXETG00000005153", "F6XEN8", "ENSXETT00000003958", "species_114520", "species_74112", "A0A6I8QV43", "ENSXETG00000005153", "F6XEN8", "ENSXETT00000003958" ] }, "reaction_10331377": { "compartment": "compartment_876", "id": "reaction_10331377", "reactome": "R-XTR-5694462", "name": "ABHD6,12 hydrolyse 3AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694509" ], "products": [ "species_422506", "species_70106", "species_76116" ], "modifiers": [ [ "species_10331374", "catalyst" ] ], "additional_components": [ "ENSXETG00000012789" ] }, "reaction_10326350": { "compartment": "compartment_70101", "id": "reaction_10326350", "reactome": "R-XTR-2179415", "name": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312049", "species_10326342" ], "products": [ "species_10326348" ], "modifiers": [], "additional_components": [ "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387", "A0A6I8QCY1", "ENSXETG00000039798", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "F7C8B9", "ENSXETT00000006761", "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10326344": { "compartment": "compartment_984", "id": "reaction_10326344", "reactome": "R-XTR-2179387", "name": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313820", "species_10313836" ], "products": [ "species_10326342" ], "modifiers": [], "additional_components": [ "ENSXETT00000006761", "ENSXETG00000039798", "A0A6I8QCY1", "ENSXETG00000039798", "F7C8B9", "ENSXETT00000006761" ] }, "reaction_10320122": { "compartment": "compartment_984", "id": "reaction_10320122", "reactome": "R-XTR-870269", "name": "Gastrin binds to CCK-B receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10319126", "species_10319130" ], "products": [ "species_10319132" ], "modifiers": [], "additional_components": [ "ENSXETT00000050945", "ENSXETT00000027311", "F6W277", "ENSXETT00000027311", "F6ZEU0", "ENSXETT00000050945" ] }, "reaction_10317737": { "compartment": "compartment_70101", "id": "reaction_10317737", "reactome": "R-XTR-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10317734", "catalyst" ] ], "additional_components": [ "F6T8H7", "ENSXETT00000040889", "A0A6I8SHT5", "ENSXETG00000011637" ] }, "reaction_10338257": { "compartment": "compartment_70101", "id": "reaction_10338257", "reactome": "R-XTR-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10312595", "catalyst" ] ], "additional_components": [ "ENSXETG00000011637" ] }, "reaction_10337052": { "compartment": "compartment_876", "id": "reaction_10337052", "reactome": "R-XTR-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337050" ], "products": [ "species_10320096", "species_10337048" ], "modifiers": [], "additional_components": [ "F7ANT3", "ENSXETT00000036860", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236", "species_29420", "F7ANT3", "ENSXETT00000036860", "species_29420", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236" ] }, "reaction_10312560": { "compartment": "compartment_70101", "id": "reaction_10312560", "reactome": "R-XTR-111881", "name": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_10312556", "species_74016" ], "products": [ "species_10312558" ], "modifiers": [], "additional_components": [ "ENSXETT00000066288", "B1WAZ6", "ENSXETT00000066288", "species_74112", "species_426925" ] }, "reaction_10312598": { "compartment": "compartment_70101", "id": "reaction_10312598", "reactome": "R-XTR-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10312595", "catalyst" ] ], "additional_components": [ "ENSXETG00000011637" ] }, "reaction_10337061": { "compartment": "compartment_876", "id": "reaction_10337061", "reactome": "R-XTR-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337056" ], "products": [ "species_29372", "species_10337050" ], "modifiers": [ [ "species_10337056", "catalyst" ] ], "additional_components": [ "F7ANT3", "ENSXETT00000036860", "species_29438", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236", "F7ANT3", "ENSXETT00000036860", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236", "species_29420", "F7ANT3", "ENSXETT00000036860", "species_29438", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236" ] }, "reaction_10337058": { "compartment": "compartment_876", "id": "reaction_10337058", "reactome": "R-XTR-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337048", "species_10337054" ], "products": [ "species_10337056" ], "modifiers": [], "additional_components": [ "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236", "F7ANT3", "ENSXETT00000036860", "species_29438", "F7ANT3", "ENSXETT00000036860", "species_29438", "Q5M8L6", "ENSXETT00000012507", "A0A6I8RVJ2", "ENSXETG00000035236" ] }, "reaction_10318153": { "compartment": "compartment_876", "id": "reaction_10318153", "reactome": "R-XTR-432067", "name": "Aquaporin-4 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10318150", "catalyst" ] ], "additional_components": [ "A0A6I8PZD7", "ENSXETG00000033655" ] }, "reaction_10318981": { "compartment": "compartment_876", "id": "reaction_10318981", "reactome": "R-XTR-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10318974", "catalyst" ] ], "additional_components": [ "A0A6I8Q4T0", "ENSXETG00000002150", "A0A6I8PZD7", "ENSXETG00000033655" ] }, "reaction_10318983": { "compartment": "compartment_876", "id": "reaction_10318983", "reactome": "R-XTR-507871", "name": "Aquaporins passively transport glycerol out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10318159", "catalyst" ] ], "additional_components": [ "A0A6I8Q4T0", "ENSXETG00000002150" ] }, "reaction_10318977": { "compartment": "compartment_876", "id": "reaction_10318977", "reactome": "R-XTR-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10318974", "catalyst" ] ], "additional_components": [ "A0A6I8Q4T0", "ENSXETG00000002150", "A0A6I8PZD7", "ENSXETG00000033655" ] }, "reaction_10318979": { "compartment": "compartment_876", "id": "reaction_10318979", "reactome": "R-XTR-507869", "name": "Aquaporins passively transport glycerol into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192438" ], "products": [ "species_76116" ], "modifiers": [ [ "species_10318159", "catalyst" ] ], "additional_components": [ "A0A6I8Q4T0", "ENSXETG00000002150" ] }, "reaction_10318162": { "compartment": "compartment_876", "id": "reaction_10318162", "reactome": "R-XTR-432074", "name": "Aquaporin-7 passively transports glycerol out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10318159", "catalyst" ] ], "additional_components": [ "A0A6I8Q4T0", "ENSXETG00000002150" ] }, "reaction_10336143": { "compartment": "compartment_7660", "id": "reaction_10336143", "reactome": "R-XTR-8936584", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336130", "species_77087" ], "products": [ "species_77502", "species_10336140" ], "modifiers": [ [ "species_10336130", "catalyst" ] ], "additional_components": [ "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10336152": { "compartment": "compartment_7660", "id": "reaction_10336152", "reactome": "R-XTR-8936608", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10336147" ], "products": [ "species_77502", "species_10336149" ], "modifiers": [ [ "species_10336147", "catalyst" ] ], "additional_components": [ "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10336170": { "compartment": "compartment_7660", "id": "reaction_10336170", "reactome": "R-XTR-8937113", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10336165" ], "products": [ "species_77502", "species_10336167" ], "modifiers": [ [ "species_10336165", "catalyst" ] ], "additional_components": [ "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10336161": { "compartment": "compartment_7660", "id": "reaction_10336161", "reactome": "R-XTR-8937022", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10336156" ], "products": [ "species_77502", "species_10336158" ], "modifiers": [ [ "species_10336156", "catalyst" ] ], "additional_components": [ "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "F6TAI6", "ENSXETT00000033424", "A0A6I8SGY5", "ENSXETG00000005253", "B0JYW5", "ENSXETG00000009939", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10326663": { "compartment": "compartment_70101", "id": "reaction_10326663", "reactome": "R-XTR-2316434", "name": "PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10326660", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "A0A6I8RUB1", "ENSXETG00000007252", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "species_179838", "A0A6I8RAF1", "ENSXETG00000039550", "A0A6I8Q186", "ENSXETG00000012933" ] }, "reaction_10316685": { "compartment": "compartment_70101", "id": "reaction_10316685", "reactome": "R-XTR-350319", "name": "Caspase mediated cleavage of vimentin at IDVD (259)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315647" ], "products": [ "species_10316674", "species_10316672" ], "modifiers": [ [ "species_10316682", "catalyst" ] ], "additional_components": [ "ENSXETG00000007462", "ENSXETG00000007462", "ENSXETG00000007462", "A0A6I8Q0P2", "ENSXETG00000032748" ] }, "reaction_10315899": { "compartment": "compartment_70101", "id": "reaction_10315899", "reactome": "R-XTR-202967", "name": "Caspase mediated cleavage of alpha-II-Fodrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315893" ], "products": [ "species_10315895", "species_10315897" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000012869", "ENSXETG00000012869", "ENSXETG00000012869", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10315654": { "compartment": "compartment_70101", "id": "reaction_10315654", "reactome": "R-XTR-201628", "name": "Caspase-mediated cleavage of vimentin at DSVD (85)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315647" ], "products": [ "species_10315651", "species_10315649" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000007462", "ENSXETG00000007462", "ENSXETG00000007462", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10315889": { "compartment": "compartment_70101", "id": "reaction_10315889", "reactome": "R-XTR-202966", "name": "Caspase mediated cleavage of HIP-55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315883" ], "products": [ "species_10315887", "species_10315885" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000019013", "ENSXETG00000019013", "ENSXETG00000019013", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10315664": { "compartment": "compartment_70101", "id": "reaction_10315664", "reactome": "R-XTR-201629", "name": "Caspase-mediated cleavage of Tau", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315658" ], "products": [ "species_10315662", "species_10315660" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000001624", "ENSXETG00000001624", "ENSXETG00000001624", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10322285": { "compartment": "compartment_70101", "id": "reaction_10322285", "reactome": "R-XTR-1247668", "name": "Hemoglobin A binds O2, releasing H+ and CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_10322281" ], "products": [ "species_70106", "species_113528", "species_10322261" ], "modifiers": [], "additional_components": [ "species_189444", "P07428", "ENSXETT00000002494", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627", "species_189444", "P07428", "ENSXETT00000002494", "species_113533", "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566" ] }, "reaction_10322216": { "compartment": "compartment_984", "id": "reaction_10322216", "reactome": "R-XTR-1237059", "name": "CA4:Zn2+ dehydrates HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10322211", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8QID1", "ENSXETG00000034545" ] }, "reaction_10314265": { "compartment": "compartment_13231", "id": "reaction_10314265", "reactome": "R-XTR-193691", "name": "NF-kB migrates to the nucleus and turns on transcription", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313343" ], "products": [ "species_10313349" ], "modifiers": [], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173" ] }, "reaction_10318346": { "compartment": "compartment_876", "id": "reaction_10318346", "reactome": "R-XTR-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10318343", "catalyst" ] ], "additional_components": [ "ENSXETG00000017762" ] }, "reaction_10318353": { "compartment": "compartment_876", "id": "reaction_10318353", "reactome": "R-XTR-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10318350", "catalyst" ] ], "additional_components": [ "ENSXETG00000019898" ] }, "reaction_10318497": { "compartment": "compartment_876", "id": "reaction_10318497", "reactome": "R-XTR-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10318343", "catalyst" ] ], "additional_components": [ "ENSXETG00000017762" ] }, "reaction_10318499": { "compartment": "compartment_876", "id": "reaction_10318499", "reactome": "R-XTR-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10318350", "catalyst" ] ], "additional_components": [ "ENSXETG00000019898" ] }, "reaction_10328233": { "compartment": "compartment_7660", "id": "reaction_10328233", "reactome": "R-XTR-3782655", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10328125" ], "products": [ "species_10328131", "species_5566518" ], "modifiers": [ [ "species_10328230", "catalyst" ] ], "additional_components": [ "A0A6I8RKR7", "ENSXETG00000035354", "ENSXETG00000031474" ] }, "reaction_10328226": { "compartment": "compartment_7660", "id": "reaction_10328226", "reactome": "R-XTR-3782637", "name": "HDAC8 deacetylates histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10328125" ], "products": [ "species_10328131", "species_5566518" ], "modifiers": [ [ "species_10328223", "catalyst" ] ], "additional_components": [ "A0A6I8RKR7", "ENSXETG00000035354", "ENSXETT00000044353" ] }, "reaction_10317294": { "compartment": "compartment_984", "id": "reaction_10317294", "reactome": "R-XTR-383313", "name": "Glucagon-like Peptide 1 is secreted from intestinal L cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317286" ], "products": [ "species_10317231" ], "modifiers": [ [ "species_10317292", "catalyst" ], [ "species_70115", "catalyst" ], [ "species_372533", "catalyst" ], [ "species_10317040", "catalyst" ] ], "additional_components": [ "ENSXETT00000028848", "ENSXETT00000028848", "ENSXETG00000038809", "ENSXETT00000045737" ] }, "reaction_10317907": { "compartment": "compartment_17957", "id": "reaction_10317907", "reactome": "R-XTR-421416", "name": "Proglucagon translocates from the ER Lumen to secretory granules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317903" ], "products": [ "species_10317905" ], "modifiers": [], "additional_components": [ "ENSXETT00000028848", "ENSXETT00000028848" ] }, "reaction_10317913": { "compartment": "compartment_17957", "id": "reaction_10317913", "reactome": "R-XTR-421426", "name": "ProGIP translocates from the ER Lumen to secretory granules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317909" ], "products": [ "species_10317911" ], "modifiers": [], "additional_components": [ "ENSXETT00000062069", "ENSXETT00000062069" ] }, "reaction_10317675": { "compartment": "compartment_984", "id": "reaction_10317675", "reactome": "R-XTR-400509", "name": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317671" ], "products": [ "species_10317673" ], "modifiers": [], "additional_components": [ "ENSXETT00000062069", "ENSXETT00000062069" ] }, "reaction_10313060": { "compartment": "compartment_20699", "id": "reaction_10313060", "reactome": "R-XTR-159796", "name": "Furin cleaves pro-factor IX to factor IX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313049" ], "products": [ "species_10313051", "species_10313053" ], "modifiers": [ [ "species_10313057", "catalyst" ] ], "additional_components": [ "ENSXETT00000025939", "ENSXETT00000025939", "ENSXETT00000025939", "ENSXETG00000015462" ] }, "reaction_10334519": { "compartment": "compartment_20699", "id": "reaction_10334519", "reactome": "R-XTR-6807224", "name": "Furin cleaves pro-BGLAP to BGLAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334513" ], "products": [ "species_10334515", "species_10334517" ], "modifiers": [ [ "species_10313057", "catalyst" ] ], "additional_components": [ "ENSXETT00000005554", "ENSXETT00000005554", "ENSXETT00000005554", "ENSXETG00000015462" ] }, "reaction_10313171": { "compartment": "compartment_20699", "id": "reaction_10313171", "reactome": "R-XTR-163798", "name": "Furin cleaves pro-protein Z to protein Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313165" ], "products": [ "species_10313169", "species_10313167" ], "modifiers": [ [ "species_10313057", "catalyst" ] ], "additional_components": [ "ENSXETT00000025939", "ENSXETT00000025939", "ENSXETT00000025939", "ENSXETG00000015462" ] }, "reaction_10322355": { "compartment": "compartment_876", "id": "reaction_10322355", "reactome": "R-XTR-1296046", "name": "KCNJs transport K+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126" ], "products": [ "species_29804" ], "modifiers": [ [ "species_10322352", "catalyst" ] ], "additional_components": [ "Q0IJ30", "ENSXETT00000049657" ] }, "reaction_10315917": { "compartment": "compartment_70101", "id": "reaction_10315917", "reactome": "R-XTR-203070", "name": "Association of profilin with monomeric actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315905", "species_10315913" ], "products": [ "species_10315915" ], "modifiers": [], "additional_components": [ "Q6P378", "ENSXETT00000057558", "species_113593", "Q6P378", "ENSXETT00000057558", "species_113593" ] }, "reaction_10328317": { "compartment": "compartment_70101", "id": "reaction_10328317", "reactome": "R-XTR-3858489", "name": "ppDVL binds DAAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328291", "species_10328313" ], "products": [ "species_10328315" ], "modifiers": [], "additional_components": [ "Q05AS8", "ENSXETG00000017212", "ENSXETG00000017030", "A0A6I8SJ25", "ENSXETG00000017030", "Q05AS8", "ENSXETG00000017212" ] }, "reaction_10330409": { "compartment": "compartment_70101", "id": "reaction_10330409", "reactome": "R-XTR-5666070", "name": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330405", "species_10330399" ], "products": [ "species_10330407" ], "modifiers": [], "additional_components": [ "A0A6I8RD71", "ENSXETG00000018144", "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8RD71", "ENSXETG00000018144" ] }, "reaction_10329929": { "compartment": "compartment_876", "id": "reaction_10329929", "reactome": "R-XTR-5623622", "name": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329921", "species_10329925" ], "products": [ "species_10329927" ], "modifiers": [], "additional_components": [ "A0A6I8R6D3", "ENSXETG00000006092", "A0A6I8PK39", "ENSXETG00000039434", "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8R6D3", "ENSXETG00000006092", "A0A6I8PK39", "ENSXETG00000039434" ] }, "reaction_10329945": { "compartment": "compartment_7660", "id": "reaction_10329945", "reactome": "R-XTR-5625717", "name": "Phosphorylated PKN1 binds androgen receptor (AR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329937", "species_10329941" ], "products": [ "species_10329943" ], "modifiers": [], "additional_components": [ "ENSXETG00000039434", "species_30321", "CHEBI:16422", "species_469662", "CHEBI:29117", "A0A6I8RK73", "ENSXETG00000005089", "species_30321", "CHEBI:16422", "species_469662", "CHEBI:29117", "A0A6I8RK73", "ENSXETG00000005089", "A0A6I8PK39", "ENSXETG00000039434" ] }, "reaction_10329961": { "compartment": "compartment_7660", "id": "reaction_10329961", "reactome": "R-XTR-5625745", "name": "PKN1 stimulates association of AR with NCOA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329957", "species_10329951" ], "products": [ "species_10329959" ], "modifiers": [], "additional_components": [ "ENSXETG00000015926", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "B5DE09", "ENSXETG00000015926" ] }, "reaction_10329973": { "compartment": "compartment_7660", "id": "reaction_10329973", "reactome": "R-XTR-5625774", "name": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329969", "species_10329951" ], "products": [ "species_10329971" ], "modifiers": [], "additional_components": [ "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10330023": { "compartment": "compartment_7660", "id": "reaction_10330023", "reactome": "R-XTR-5625848", "name": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10330008", "species_113685" ], "products": [ "species_10330020", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10330008", "catalyst" ] ], "additional_components": [ "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803" ] }, "reaction_10329990": { "compartment": "compartment_7660", "id": "reaction_10329990", "reactome": "R-XTR-5625784", "name": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10329971" ], "products": [ "species_113582", "species_10329987" ], "modifiers": [ [ "species_10329971", "catalyst" ] ], "additional_components": [ "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354" ] }, "reaction_10329953": { "compartment": "compartment_70101", "id": "reaction_10329953", "reactome": "R-XTR-5625738", "name": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329943" ], "products": [ "species_10329951" ], "modifiers": [], "additional_components": [ "species_30321", "CHEBI:16422", "species_469662", "CHEBI:29117", "A0A6I8RK73", "ENSXETG00000005089", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PK39", "ENSXETG00000039434" ] }, "reaction_10330047": { "compartment": "compartment_70101", "id": "reaction_10330047", "reactome": "R-XTR-5626507", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330039", "species_10330043" ], "products": [ "species_10330045" ], "modifiers": [], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8S827", "ENSXETG00000020384", "Q6P378", "ENSXETT00000057558", "species_113593", "Q6P378", "ENSXETT00000057558", "species_113593", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8S827", "ENSXETG00000020384" ] }, "reaction_10330041": { "compartment": "compartment_70101", "id": "reaction_10330041", "reactome": "R-XTR-5626469", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330037", "species_10312717" ], "products": [ "species_10330039" ], "modifiers": [], "additional_components": [ "A0A6I8S827", "ENSXETG00000020384", "Q6GL60", "ENSXETT00000092508", "species_29438", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8S827", "ENSXETG00000020384" ] }, "reaction_10337088": { "compartment": "compartment_5460", "id": "reaction_10337088", "reactome": "R-XTR-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337081" ], "products": [], "modifiers": [ [ "species_10337085", "catalyst" ] ], "additional_components": [ "A0A6I8SHX8", "ENSXETG00000041384", "ENSXETG00000009818" ] }, "reaction_10329865": { "compartment": "compartment_24337", "id": "reaction_10329865", "reactome": "R-XTR-5610763", "name": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329855" ], "products": [ "species_10329859" ], "modifiers": [ [ "species_10329863", "inhibitor" ] ], "additional_components": [ "A0A6I8RRT2", "ENSXETG00000014939", "A0A6I8RRT2", "ENSXETG00000014939", "ENSXETG00000014834" ] }, "reaction_10329849": { "compartment": "compartment_876", "id": "reaction_10329849", "reactome": "R-XTR-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10329846", "catalyst" ] ], "additional_components": [ "species_109496" ] }, "reaction_10330636": { "compartment": "compartment_7660", "id": "reaction_10330636", "reactome": "R-XTR-5683831", "name": "CCDC59 binds TTF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330628", "species_10330632" ], "products": [ "species_10330634" ], "modifiers": [], "additional_components": [ "ENSXETT00000031815", "ENSXETG00000040672", "A0A6I8R1F2", "ENSXETG00000040672", "F6XAD1", "ENSXETT00000031815" ] }, "reaction_10330828": { "compartment": "compartment_876", "id": "reaction_10330828", "reactome": "R-XTR-5686286", "name": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330816" ], "products": [ "species_10330826" ], "modifiers": [], "additional_components": [ "A0A6I8SVN5", "ENSXETG00000009325", "F6ULZ5", "ENSXETT00000023447", "F6ULZ5", "ENSXETT00000023447", "A0A6I8SVN5", "ENSXETG00000009325" ] }, "reaction_10337007": { "compartment": "compartment_12045", "id": "reaction_10337007", "reactome": "R-XTR-8961021", "name": "SFTPD binds with itself to form SFTPD 12mer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337003" ], "products": [ "species_10337005" ], "modifiers": [], "additional_components": [ "A0A6I8R9D1", "ENSXETG00000034779", "A0A6I8R9D1", "ENSXETG00000034779" ] }, "reaction_10330798": { "compartment": "compartment_12045", "id": "reaction_10330798", "reactome": "R-XTR-5685649", "name": "SFTPAs translocate from ER membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330794" ], "products": [ "species_10330796" ], "modifiers": [], "additional_components": [ "A0A6I8SVN5", "ENSXETG00000009325", "A0A6I8SVN5", "ENSXETG00000009325" ] }, "reaction_10330830": { "compartment": "compartment_876", "id": "reaction_10330830", "reactome": "R-XTR-5686301", "name": "PALM-C100-CKAP4 binds SFTPAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330814", "species_10330796" ], "products": [ "species_10330816" ], "modifiers": [], "additional_components": [ "ENSXETT00000023447", "A0A6I8SVN5", "ENSXETG00000009325", "A0A6I8SVN5", "ENSXETG00000009325", "F6ULZ5", "ENSXETT00000023447" ] }, "reaction_10330809": { "compartment": "compartment_3828046", "id": "reaction_10330809", "reactome": "R-XTR-5685902", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5685882", "species_10330697" ], "products": [ "species_10330802", "species_10330800" ], "modifiers": [ [ "species_10330806", "catalyst" ] ], "additional_components": [ "ENSXETG00000031314", "ENSXETG00000031314", "ENSXETG00000031314", "ENSXETT00000003012" ] }, "reaction_10331288": { "compartment": "compartment_984", "id": "reaction_10331288", "reactome": "R-XTR-5693346", "name": "CECRI deaminates Ade-Rib to Ino", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_83908" ], "products": [ "species_2022135", "species_83921" ], "modifiers": [ [ "species_10331285", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8QUN5", "ENSXETG00000039169" ] }, "reaction_10330699": { "compartment": "compartment_12045", "id": "reaction_10330699", "reactome": "R-XTR-5684868", "name": "pro-SFTPC translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330695" ], "products": [ "species_10330697" ], "modifiers": [], "additional_components": [ "ENSXETG00000031314", "ENSXETG00000031314" ] }, "reaction_10337812": { "compartment": "compartment_12045", "id": "reaction_10337812", "reactome": "R-XTR-9624778", "name": "SFTPD 12mer translocates from ER membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337005" ], "products": [ "species_10337810" ], "modifiers": [], "additional_components": [ "A0A6I8R9D1", "ENSXETG00000034779", "A0A6I8R9D1", "ENSXETG00000034779" ] }, "reaction_10336078": { "compartment": "compartment_70101", "id": "reaction_10336078", "reactome": "R-XTR-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336068", "species_71284" ], "products": [ "species_10336071", "species_71285" ], "modifiers": [ [ "species_10336075", "catalyst" ] ], "additional_components": [ "ENSXETT00000067185", "ENSXETT00000067185", "ENSXETG00000037439" ] }, "reaction_10336088": { "compartment": "compartment_70101", "id": "reaction_10336088", "reactome": "R-XTR-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312906", "species_71284" ], "products": [ "species_10336081", "species_71285" ], "modifiers": [ [ "species_10336085", "catalyst" ] ], "additional_components": [ "ENSXETG00000037123", "ENSXETG00000037123", "ENSXETG00000030721" ] }, "reaction_10336059": { "compartment": "compartment_70101", "id": "reaction_10336059", "reactome": "R-XTR-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312906", "species_71284" ], "products": [ "species_10336052", "species_71285" ], "modifiers": [ [ "species_10336056", "catalyst" ] ], "additional_components": [ "ENSXETG00000037123", "ENSXETG00000037123", "ENSXETG00000033485" ] }, "reaction_10313177": { "compartment": "compartment_13959", "id": "reaction_10313177", "reactome": "R-XTR-163825", "name": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313175" ], "products": [ "species_10313165" ], "modifiers": [], "additional_components": [ "ENSXETT00000025939", "ENSXETT00000025939" ] }, "reaction_10334521": { "compartment": "compartment_13959", "id": "reaction_10334521", "reactome": "R-XTR-6807229", "name": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334511" ], "products": [ "species_10334513" ], "modifiers": [], "additional_components": [ "ENSXETT00000005554", "ENSXETT00000005554" ] }, "reaction_10313066": { "compartment": "compartment_13959", "id": "reaction_10313066", "reactome": "R-XTR-159836", "name": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313064" ], "products": [ "species_10313049" ], "modifiers": [], "additional_components": [ "ENSXETT00000025939", "ENSXETT00000025939" ] }, "reaction_10316020": { "compartment": "compartment_70101", "id": "reaction_10316020", "reactome": "R-XTR-204617", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_10316005", "species_204628", "species_73473" ], "products": [ "species_204635", "species_10316009", "species_29360" ], "modifiers": [ [ "species_10316017", "catalyst" ] ], "additional_components": [ "ENSXETG00000034500", "ENSXETG00000034500", "F6RYK2", "ENSXETT00000012343" ] }, "reaction_10316036": { "compartment": "compartment_70101", "id": "reaction_10316036", "reactome": "R-XTR-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_10316005", "species_29368", "species_73473" ], "products": [ "species_29356", "species_10316025", "species_29360" ], "modifiers": [ [ "species_10316033", "catalyst" ] ], "additional_components": [ "ENSXETG00000034500", "ENSXETG00000034500", "A0A6I8SV44", "ENSXETG00000040489", "species_435347" ] }, "reaction_10338051": { "compartment": "compartment_17963", "id": "reaction_10338051", "reactome": "R-XTR-9668023", "name": "TPST1,2 transfer SO4(2-) from PAPS to FVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10338041" ], "products": [ "species_10338049", "species_742343" ], "modifiers": [ [ "species_10336936", "catalyst" ] ], "additional_components": [ "ENSXETG00000038196", "ENSXETG00000038196", "ENSXETG00000017664" ] }, "reaction_10321802": { "compartment": "compartment_70101", "id": "reaction_10321802", "reactome": "R-XTR-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10321798" ], "products": [ "species_10321800" ], "modifiers": [], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "CHEBI:60627", "CHEBI:60628", "CHEBI:59092", "CHEBI:60629", "CHEBI:59087", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858" ] }, "reaction_10335136": { "compartment": "compartment_70101", "id": "reaction_10335136", "reactome": "R-XTR-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10321800" ], "products": [ "species_8853371", "species_8853381" ], "modifiers": [ [ "species_10335133", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "CHEBI:59092", "CHEBI:60629", "CHEBI:59087", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "CHEBI:91280", "CHEBI:91284", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "ENSXETT00000043623" ] }, "reaction_10328409": { "compartment": "compartment_17963", "id": "reaction_10328409", "reactome": "R-XTR-4084984", "name": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_4086285" ], "products": [ "species_4086277", "species_727810" ], "modifiers": [ [ "species_10325929", "catalyst" ] ], "additional_components": [ "ENSXETG00000026104" ] }, "reaction_10328407": { "compartment": "compartment_20699", "id": "reaction_10328407", "reactome": "R-XTR-4084978", "name": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_4088006" ], "products": [ "species_727810", "species_4087982" ], "modifiers": [ [ "species_10328404", "catalyst" ] ], "additional_components": [ "A0A6I8Q045", "ENSXETG00000024127", "A1KQY5", "ENSXETT00000075006", "Q6DNG6", "ENSXETG00000023481", "A0A6I8QSS5", "ENSXETG00000035254", "A0A6I8S6X4", "ENSXETG00000039548" ] }, "reaction_10328418": { "compartment": "compartment_70101", "id": "reaction_10328418", "reactome": "R-XTR-4085217", "name": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4088096" ], "products": [ "species_4088099", "species_29398" ], "modifiers": [ [ "species_10328415", "catalyst" ] ], "additional_components": [ "species_975925", "CHEBI:29025", "CHEBI:17122", "CHEBI:28255", "Q5M905", "ENSXETT00000033244" ] }, "reaction_10333998": { "compartment": "compartment_70101", "id": "reaction_10333998", "reactome": "R-XTR-6803771", "name": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803785", "species_113592" ], "products": [ "species_6803738", "species_70106", "species_29370" ], "modifiers": [ [ "species_10333995", "catalyst" ] ], "additional_components": [ "CHEBI:27459", "species_1678743", "CHEBI:15784", "CHEBI:88130", "A0A5K1VLH5", "ENSXETT00000012241" ] }, "reaction_10318563": { "compartment": "compartment_70101", "id": "reaction_10318563", "reactome": "R-XTR-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512", "species_29472" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10318560", "catalyst" ] ], "additional_components": [ "ENSXETT00000029938" ] }, "reaction_10319089": { "compartment": "compartment_20699", "id": "reaction_10319089", "reactome": "R-XTR-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10319086", "catalyst" ] ], "additional_components": [ "ENSXETG00000036219" ] }, "reaction_10332336": { "compartment": "compartment_70101", "id": "reaction_10332336", "reactome": "R-XTR-6787540", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6787678" ], "products": [ "species_29370", "species_6787542" ], "modifiers": [ [ "species_10332333", "catalyst" ] ], "additional_components": [ "ENSXETG00000040982" ] }, "reaction_10320776": { "compartment": "compartment_20699", "id": "reaction_10320776", "reactome": "R-XTR-975916", "name": "Addition of GlcNAc to position 5 by MGAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981617" ], "modifiers": [ [ "species_10320773", "catalyst" ] ], "additional_components": [ "ENSXETG00000000514" ] }, "reaction_10321819": { "compartment": "compartment_20699", "id": "reaction_10321819", "reactome": "R-XTR-1022133", "name": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975925", "species_975910" ], "products": [ "species_981615" ], "modifiers": [ [ "species_10321816", "catalyst" ] ], "additional_components": [ "A0A6I8Q045", "ENSXETG00000024127", "A0A6I8QSS5", "ENSXETG00000035254", "Q6DNG6", "ENSXETG00000023481" ] }, "reaction_10320769": { "compartment": "compartment_20699", "id": "reaction_10320769", "reactome": "R-XTR-975903", "name": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981616" ], "modifiers": [ [ "species_10320766", "catalyst" ] ], "additional_components": [ "ENSXETG00000019401" ] }, "reaction_10320785": { "compartment": "compartment_20699", "id": "reaction_10320785", "reactome": "R-XTR-975919", "name": "Addition of galactose by beta 4-galactosyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_975910" ], "products": [ "species_981618" ], "modifiers": [ [ "species_10320782", "catalyst" ] ], "additional_components": [ "A0A6I8QS90", "ENSXETG00000034513" ] }, "reaction_10320729": { "compartment": "compartment_17963", "id": "reaction_10320729", "reactome": "R-XTR-964759", "name": "Alternative endo-mannosidase I route", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964754" ], "products": [ "species_964744", "species_964746" ], "modifiers": [ [ "species_10320726", "catalyst" ] ], "additional_components": [ "ENSXETG00000038826" ] }, "reaction_10335243": { "compartment": "compartment_984", "id": "reaction_10335243", "reactome": "R-XTR-8855711", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855720", "species_10335239" ], "products": [ "species_10335241" ], "modifiers": [], "additional_components": [ "A0A6I8Q6M7", "ENSXETG00000041320", "A0A6I8Q6M7", "ENSXETG00000041320", "species_8855720" ] }, "reaction_10335258": { "compartment": "compartment_20699", "id": "reaction_10335258", "reactome": "R-XTR-8855954", "name": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335248", "species_735682" ], "products": [ "species_10335251", "species_205687" ], "modifiers": [ [ "species_10335255", "catalyst" ] ], "additional_components": [ "ENSXETG00000037485", "ENSXETG00000037485", "ENSXETG00000033376" ] }, "reaction_10335149": { "compartment": "compartment_70101", "id": "reaction_10335149", "reactome": "R-XTR-8853529", "name": "OTULIN,USP5 cleaves UBB yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335147" ], "products": [ "species_10312090", "species_10312094", "species_10312092" ], "modifiers": [ [ "species_10335142", "catalyst" ] ], "additional_components": [ "ENSXETG00000037858", "ENSXETG00000037858", "ENSXETG00000037858", "ENSXETG00000037858", "ENSXETT00000003610" ] }, "reaction_10335145": { "compartment": "compartment_70101", "id": "reaction_10335145", "reactome": "R-XTR-8853515", "name": "OTULIN,USP5 cleaves UBC yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335138" ], "products": [ "species_10312114", "species_10312098", "species_10312112", "species_10312102", "species_10312100", "species_10312106", "species_10312104", "species_10312110", "species_10312108" ], "modifiers": [ [ "species_10335142", "catalyst" ] ], "additional_components": [ "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETG00000036372", "ENSXETT00000003610" ] }, "reaction_10313091": { "compartment": "compartment_17957", "id": "reaction_10313091", "reactome": "R-XTR-162729", "name": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_10313078" ], "products": [ "species_1524021", "species_10313084" ], "modifiers": [ [ "species_10313088", "catalyst" ] ], "additional_components": [ "A0A6I8PQQ3", "ENSXETG00000033079", "A0A6I8SLF2", "ENSXETG00000037404", "A0A6I8PQQ3", "ENSXETG00000033079", "A0A6I8SLF2", "ENSXETG00000037404", "ENSXETG00000034065" ] }, "reaction_10313104": { "compartment": "compartment_12045", "id": "reaction_10313104", "reactome": "R-XTR-162742", "name": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855660" ], "products": [ "species_8855660" ], "modifiers": [ [ "species_10313101", "catalyst" ] ], "additional_components": [ "A0A6I8QRW2", "ENSXETG00000003720", "B7ZT49", "ENSXETT00000055317" ] }, "reaction_10313123": { "compartment": "compartment_70101", "id": "reaction_10313123", "reactome": "R-XTR-162857", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855657", "species_29356" ], "products": [ "species_8855661", "species_29416" ], "modifiers": [ [ "species_10313120", "catalyst" ] ], "additional_components": [ "ENSXETG00000038618" ] }, "reaction_10327110": { "compartment": "compartment_7660", "id": "reaction_10327110", "reactome": "R-XTR-2990833", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10327093", "species_10327097" ], "products": [ "species_10327107", "species_164121", "species_113541" ], "modifiers": [ [ "species_10327093", "catalyst" ] ], "additional_components": [ "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374", "ENSXETG00000022072", "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374", "Q6DEP7", "ENSXETG00000022072", "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374" ] }, "reaction_10327143": { "compartment": "compartment_7660", "id": "reaction_10327143", "reactome": "R-XTR-2993780", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327107", "species_10327128" ], "products": [ "species_10327136", "species_10327093" ], "modifiers": [ [ "species_10327093", "catalyst" ], [ "species_10327141", "catalyst" ] ], "additional_components": [ "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374", "Q6DEP7", "ENSXETG00000022072", "ENSXETT00000054232", "Q6DEP7", "ENSXETG00000022072", "Q28CQ4", "ENSXETT00000054232", "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374", "Q28DS0", "ENSXETT00000000333", "Q28GH3", "ENSXETG00000002374", "ENSXETG00000025843" ] }, "reaction_10325469": { "compartment": "compartment_984", "id": "reaction_10325469", "reactome": "R-XTR-2022411", "name": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10325445" ], "products": [ "species_10316956" ], "modifiers": [ [ "species_10325464", "catalyst" ] ], "additional_components": [ "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "ENSXETT00000037000" ] }, "reaction_10325439": { "compartment": "compartment_984", "id": "reaction_10325439", "reactome": "R-XTR-2022368", "name": "Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325426", "species_109276" ], "products": [ "species_10325432" ], "modifiers": [ [ "species_10325436", "catalyst" ] ], "additional_components": [ "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "ENSXETG00000007771" ] }, "reaction_10325448": { "compartment": "compartment_984", "id": "reaction_10325448", "reactome": "R-XTR-2022383", "name": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10325445" ], "products": [ "species_10316956" ], "modifiers": [ [ "species_10323745", "catalyst" ] ], "additional_components": [ "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "ENSXETT00000037000" ] }, "reaction_10325450": { "compartment": "compartment_984", "id": "reaction_10325450", "reactome": "R-XTR-2022396", "name": "Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10325445" ], "products": [ "species_10325432" ], "modifiers": [ [ "species_10325436", "catalyst" ] ], "additional_components": [ "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "ENSXETG00000007771" ] }, "reaction_10337782": { "compartment": "compartment_984", "id": "reaction_10337782", "reactome": "R-XTR-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10331304", "catalyst" ] ], "additional_components": [ "A0A5G3JDL4", "ENSXETT00000103127" ] }, "reaction_10325793": { "compartment": "compartment_984", "id": "reaction_10325793", "reactome": "R-XTR-2028294", "name": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10325445" ], "products": [ "species_10325426" ], "modifiers": [ [ "species_10325790", "catalyst" ] ], "additional_components": [ "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "F7BFR9", "ENSXETT00000050417", "Q6P614", "ENSXETT00000057632", "A0A6I8PU97", "ENSXETG00000033023" ] }, "reaction_10317212": { "compartment": "compartment_984", "id": "reaction_10317212", "reactome": "R-XTR-381412", "name": "IGFBP2 binds IGF forming IGF:IGFBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317204", "species_10317208" ], "products": [ "species_10317210" ], "modifiers": [], "additional_components": [ "ENSXETT00000094605", "ENSXETT00000006287", "F7CZB7", "ENSXETT00000006287", "A4IIA2", "ENSXETT00000094605" ] }, "reaction_10317228": { "compartment": "compartment_984", "id": "reaction_10317228", "reactome": "R-XTR-381545", "name": "Formation of the IGF:IGFBP5:ALS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317216", "species_10317220", "species_10317208" ], "products": [ "species_10317222" ], "modifiers": [], "additional_components": [ "ENSXETG00000006623", "ENSXETT00000074759", "ENSXETT00000006287", "F7CZB7", "ENSXETT00000006287", "Q0IJ34", "ENSXETT00000074759", "A0A6I8PJ44", "ENSXETG00000006623" ] }, "reaction_10331191": { "compartment": "compartment_70101", "id": "reaction_10331191", "reactome": "R-XTR-5691512", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5691496", "species_29356" ], "products": [ "species_6785226", "species_5691517" ], "modifiers": [ [ "species_10331188", "catalyst" ] ], "additional_components": [ "species_5691517", "species_6785226", "ENSXETT00000050806" ] }, "reaction_10330583": { "compartment": "compartment_70101", "id": "reaction_10330583", "reactome": "R-XTR-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_5687529", "species_71285" ], "modifiers": [ [ "species_10330580", "catalyst" ] ], "additional_components": [ "ENSXETG00000017500" ] }, "reaction_10337612": { "compartment": "compartment_70101", "id": "reaction_10337612", "reactome": "R-XTR-9033232", "name": "PEX7 binds cargo proteins containing PTS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337604", "species_10337608" ], "products": [ "species_10337610" ], "modifiers": [], "additional_components": [ "ENSXETG00000027656", "ENSXETG00000008462", "A0A6I8R668", "ENSXETG00000008462", "A0A6I8SMH6", "ENSXETG00000027656" ] }, "reaction_10336877": { "compartment": "compartment_876", "id": "reaction_10336877", "reactome": "R-XTR-8951586", "name": "p-VAV family:PIP3 binds RAC1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325847", "species_10329285" ], "products": [ "species_10329291" ], "modifiers": [], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29420", "species_179838", "L7N3Q8", "ENSXETT00000043225", "species_179838", "L7N3Q8", "ENSXETT00000043225", "Q6GL60", "ENSXETT00000092508", "species_29420" ] }, "reaction_10329594": { "compartment": "compartment_876", "id": "reaction_10329594", "reactome": "R-XTR-5357445", "name": "PAK1-3 dimer disassociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329590" ], "products": [ "species_10329592" ], "modifiers": [], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "A0A6I8T271", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10329601": { "compartment": "compartment_876", "id": "reaction_10329601", "reactome": "R-XTR-5357472", "name": "PAK1-3 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10329592" ], "products": [ "species_29370", "species_10329598", "species_10329293" ], "modifiers": [ [ "species_10317378", "catalyst" ] ], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "A0A6I8T271", "ENSXETG00000011808", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10329603": { "compartment": "compartment_876", "id": "reaction_10329603", "reactome": "R-XTR-5357483", "name": "RAC1 binds PAK1-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317378", "species_10329293" ], "products": [ "species_10329590" ], "modifiers": [], "additional_components": [ "A0A6I8T271", "ENSXETG00000011808", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "A0A6I8T271", "ENSXETG00000011808" ] }, "reaction_10329279": { "compartment": "compartment_70101", "id": "reaction_10329279", "reactome": "R-XTR-5218805", "name": "PKC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10329272" ], "products": [ "species_29370", "species_10329276" ], "modifiers": [ [ "species_10329272", "catalyst" ] ], "additional_components": [ "ENSXETG00000017294", "ENSXETG00000017294", "ENSXETG00000017294" ] }, "reaction_10329296": { "compartment": "compartment_876", "id": "reaction_10329296", "reactome": "R-XTR-5218850", "name": "VAV exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10329291" ], "products": [ "species_29420", "species_10329293" ], "modifiers": [ [ "species_10329291", "catalyst" ] ], "additional_components": [ "species_179838", "L7N3Q8", "ENSXETT00000043225", "Q6GL60", "ENSXETT00000092508", "species_29420", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225", "species_179838", "L7N3Q8", "ENSXETT00000043225", "Q6GL60", "ENSXETT00000092508", "species_29420" ] }, "reaction_10315879": { "compartment": "compartment_70101", "id": "reaction_10315879", "reactome": "R-XTR-202960", "name": "Caspase mediated cleavage of C-IAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315857" ], "products": [ "species_10315877", "species_10315867" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8QAZ5", "ENSXETG00000039278", "A0A6I8QAZ5", "ENSXETG00000039278", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8QAZ5", "ENSXETG00000039278", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10315839": { "compartment": "compartment_70101", "id": "reaction_10315839", "reactome": "R-XTR-202917", "name": "Caspase-mediated cleavage of Desmoglein 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315833" ], "products": [ "species_10315835", "species_10315837" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000034243", "ENSXETG00000034243", "ENSXETG00000034243", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10316731": { "compartment": "compartment_876", "id": "reaction_10316731", "reactome": "R-XTR-351913", "name": "Caspase-mediated cleavage of TJP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316727" ], "products": [ "species_10316729" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000020296", "ENSXETG00000020296", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10315674": { "compartment": "compartment_70101", "id": "reaction_10315674", "reactome": "R-XTR-201631", "name": "Caspase-mediated cleavage of Desmoglein 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315668" ], "products": [ "species_10315670", "species_10315672" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000034243", "ENSXETG00000034243", "ENSXETG00000034243", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10316723": { "compartment": "compartment_876", "id": "reaction_10316723", "reactome": "R-XTR-351877", "name": "Caspase-mediated cleavage of Desmoglein 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316719" ], "products": [ "species_10316721" ], "modifiers": [ [ "species_10312650", "catalyst" ] ], "additional_components": [ "ENSXETG00000034243", "ENSXETG00000034243", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10334778": { "compartment": "compartment_70101", "id": "reaction_10334778", "reactome": "R-XTR-8848726", "name": "PTK6 phosphorylates BCAR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334769", "species_113592" ], "products": [ "species_10334775", "species_10334679", "species_29370" ], "modifiers": [ [ "species_10334769", "catalyst" ] ], "additional_components": [ "L7N3R0", "ENSXETT00000043234", "A0A6I8Q2T5", "ENSXETG00000031017", "ENSXETT00000043234", "ENSXETG00000031017", "L7N3R0", "ENSXETT00000043234", "A0A6I8Q2T5", "ENSXETG00000031017" ] }, "reaction_10334771": { "compartment": "compartment_70101", "id": "reaction_10334771", "reactome": "R-XTR-8848713", "name": "PTK6 binds BCAR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334679", "species_10334767" ], "products": [ "species_10334769" ], "modifiers": [], "additional_components": [ "ENSXETG00000031017", "ENSXETT00000043234", "L7N3R0", "ENSXETT00000043234", "A0A6I8Q2T5", "ENSXETG00000031017" ] }, "reaction_10334782": { "compartment": "compartment_70101", "id": "reaction_10334782", "reactome": "R-XTR-8848930", "name": "PTK6 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334679" ], "products": [ "species_10334780" ], "modifiers": [], "additional_components": [ "ENSXETG00000031017", "ENSXETG00000031017" ] }, "reaction_10334792": { "compartment": "compartment_7660", "id": "reaction_10334792", "reactome": "R-XTR-8849032", "name": "PTK6 phosphorylates KHDRBS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334786", "species_29358" ], "products": [ "species_113582", "species_10334789" ], "modifiers": [ [ "species_10334780", "catalyst" ] ], "additional_components": [ "ENSXETG00000004451", "ENSXETG00000004451", "ENSXETG00000031017" ] }, "reaction_10334682": { "compartment": "compartment_70101", "id": "reaction_10334682", "reactome": "R-XTR-8848005", "name": "ERBB2 promotes PTK6 autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334674", "species_113592" ], "products": [ "species_10334679", "species_29370", "species_10322318" ], "modifiers": [ [ "species_10334674", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "A0A6I8Q2T5", "ENSXETG00000031017", "ENSXETG00000031017", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "A0A6I8Q2T5", "ENSXETG00000031017" ] }, "reaction_10334676": { "compartment": "compartment_876", "id": "reaction_10334676", "reactome": "R-XTR-8847995", "name": "Activated ERBB2 binds PTK6 (BRK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334672", "species_10322318" ], "products": [ "species_10334674" ], "modifiers": [], "additional_components": [ "ENSXETG00000031017", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "A0A6I8Q2T5", "ENSXETG00000031017" ] }, "reaction_10334802": { "compartment": "compartment_70101", "id": "reaction_10334802", "reactome": "R-XTR-8849102", "name": "SRMS phosphorylates PTK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334679", "species_113592" ], "products": [ "species_29370", "species_10334795" ], "modifiers": [ [ "species_10334799", "catalyst" ] ], "additional_components": [ "ENSXETG00000031017", "ENSXETG00000031017", "ENSXETG00000034490" ] }, "reaction_10318268": { "compartment": "compartment_876", "id": "reaction_10318268", "reactome": "R-XTR-442317", "name": "ZIP6 and ZIP14 mediate zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10318265", "catalyst" ] ], "additional_components": [ "ENSXETG00000010532" ] }, "reaction_10318288": { "compartment": "compartment_876", "id": "reaction_10318288", "reactome": "R-XTR-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10318285", "catalyst" ] ], "additional_components": [ "ENSXETG00000035832" ] }, "reaction_10337769": { "compartment": "compartment_70101", "id": "reaction_10337769", "reactome": "R-XTR-9614423", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316178", "species_10312804" ], "products": [ "species_10337767" ], "modifiers": [], "additional_components": [ "ENSXETT00000101788", "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830", "Q6P4Z5", "ENSXETT00000013608", "Q5XGC8", "ENSXETG00000022830", "Q66JJ0", "ENSXETT00000101788" ] }, "reaction_10337765": { "compartment": "compartment_7660", "id": "reaction_10337765", "reactome": "R-XTR-9614414", "name": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315552" ], "products": [ "species_10316178" ], "modifiers": [], "additional_components": [ "ENSXETT00000101788", "ENSXETT00000101788" ] }, "reaction_10337071": { "compartment": "compartment_7660", "id": "reaction_10337071", "reactome": "R-XTR-8985343", "name": "RUNX2 binds SOX9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337067", "species_10335995" ], "products": [ "species_10337069" ], "modifiers": [], "additional_components": [ "ENSXETT00000087663", "ENSXETG00000001397", "Q6F2E7", "ENSXETT00000087663", "A0A6I8PZM7", "ENSXETG00000001397" ] }, "reaction_10336222": { "compartment": "compartment_7660", "id": "reaction_10336222", "reactome": "R-XTR-8938356", "name": "RMB14 binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336218", "species_10335995" ], "products": [ "species_10336220" ], "modifiers": [], "additional_components": [ "ENSXETG00000026650", "ENSXETG00000001397", "A0A6I8PZM7", "ENSXETG00000001397", "A0A6I8PSM7", "ENSXETG00000026650" ] }, "reaction_10336001": { "compartment": "compartment_7660", "id": "reaction_10336001", "reactome": "R-XTR-8877902", "name": "Activated AR binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335995", "species_10329949" ], "products": [ "species_10335999" ], "modifiers": [], "additional_components": [ "ENSXETG00000001397", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8RK73", "ENSXETG00000005089", "species_469662", "CHEBI:29117", "species_30321", "CHEBI:16422", "A0A6I8PZM7", "ENSXETG00000001397" ] }, "reaction_10317275": { "compartment": "compartment_7660", "id": "reaction_10317275", "reactome": "R-XTR-382096", "name": "Formation of NR-NCOR Corepressor Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317154", "species_10317271" ], "products": [ "species_10317273" ], "modifiers": [], "additional_components": [ "A4IIG7", "ENSXETT00000011580", "A0A6I8S377", "ENSXETT00000011580", "A0A6I8QVA7", "ENSXETG00000005219", "A0A6I8RH34", "ENSXETG00000031759", "F7EHW3", "ENSXETT00000025024", "F6SI83", "ENSXETT00000040897", "F6V3Y1", "ENSXETT00000012055", "A0A6I8S149", "ENSXETG00000040373", "F7C0K4", "ENSXETT00000050646", "A0A6I8QBV8", "ENSXETG00000021123", "Q28CK1", "ENSXETG00000023840", "A0A6I8QMK1", "ENSXETG00000007693", "F6WU58", "ENSXETT00000039111", "F7ETJ5", "ENSXETT00000028937", "F7BMW5", "ENSXETT00000027035", "Q66JK1", "ENSXETT00000090817", "A0A6I8RK73", "ENSXETG00000005089", "ENSXETG00000006720", "Q4KKX4", "ENSXETG00000006720", "A4IIG7", "ENSXETT00000011580", "A0A6I8S377", "ENSXETT00000011580", "A0A6I8QVA7", "ENSXETG00000005219", "A0A6I8RH34", "ENSXETG00000031759", "F7EHW3", "ENSXETT00000025024", "F6SI83", "ENSXETT00000040897", "F6V3Y1", "ENSXETT00000012055", "A0A6I8S149", "ENSXETG00000040373", "F7C0K4", "ENSXETT00000050646", "A0A6I8QBV8", "ENSXETG00000021123", "Q28CK1", "ENSXETG00000023840", "A0A6I8QMK1", "ENSXETG00000007693", "F6WU58", "ENSXETT00000039111", "F7ETJ5", "ENSXETT00000028937", "F7BMW5", "ENSXETT00000027035", "Q66JK1", "ENSXETT00000090817", "A0A6I8RK73", "ENSXETG00000005089" ] }, "reaction_10335895": { "compartment": "compartment_7660", "id": "reaction_10335895", "reactome": "R-XTR-8871260", "name": "YAP1 binds TEAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325861", "species_10325849" ], "products": [ "species_10335893" ], "modifiers": [], "additional_components": [ "ENSXETG00000036112", "ENSXETG00000032689", "A0A6I8SYU4", "ENSXETG00000032689", "A0A6I8SG09", "ENSXETG00000036112" ] }, "reaction_10325859": { "compartment": "compartment_7660", "id": "reaction_10325859", "reactome": "R-XTR-2032775", "name": "YAP1 binds TEAD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325849", "species_10325855" ], "products": [ "species_10325857" ], "modifiers": [], "additional_components": [ "ENSXETG00000032689", "ENSXETG00000036112", "A0A6I8SG09", "ENSXETG00000036112", "A0A6I8SYU4", "ENSXETG00000032689" ] }, "reaction_10326415": { "compartment": "compartment_70101", "id": "reaction_10326415", "reactome": "R-XTR-2187395", "name": "Dephosphorylated SMAD2/3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326413" ], "products": [ "species_10323441" ], "modifiers": [], "additional_components": [ "ENSXETT00000061335", "ENSXETT00000061335" ] }, "reaction_10337276": { "compartment": "compartment_876", "id": "reaction_10337276", "reactome": "R-XTR-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10325847" ], "products": [ "species_29420", "species_10312717" ], "modifiers": [ [ "species_10337273", "catalyst" ] ], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29420", "Q6GL60", "ENSXETT00000092508", "species_29438", "B1H2U7", "ENSXETT00000094272", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10337311": { "compartment": "compartment_876", "id": "reaction_10337311", "reactome": "R-XTR-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10312717" ], "products": [ "species_29372", "species_10325847" ], "modifiers": [ [ "species_10337308", "catalyst" ] ], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "Q6GL60", "ENSXETT00000092508", "species_29420", "Q08CX6", "ENSXETT00000056057", "A0A6I8SWA3", "ENSXETG00000032660", "A0A6I8SAF2", "ENSXETG00000004047", "F6UHQ8", "ENSXETT00000010378", "A0A6I8QAR5", "ENSXETG00000003287" ] }, "reaction_10337349": { "compartment": "compartment_876", "id": "reaction_10337349", "reactome": "R-XTR-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337345", "species_10325847" ], "products": [ "species_10337347" ], "modifiers": [], "additional_components": [ "ENSXETT00000020510", "Q6GL60", "ENSXETT00000092508", "species_29420", "F7D6Y2", "ENSXETT00000020510", "species_29420", "Q6GL60", "ENSXETT00000092508" ] }, "reaction_10338163": { "compartment": "compartment_876", "id": "reaction_10338163", "reactome": "R-XTR-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312717" ], "products": [ "species_10330027" ], "modifiers": [], "additional_components": [ "Q6GL60", "ENSXETT00000092508", "species_29438", "Q6GL60", "ENSXETT00000092508", "species_29438" ] }, "reaction_10330269": { "compartment": "compartment_7660", "id": "reaction_10330269", "reactome": "R-XTR-5655193", "name": "KIAA0101 double monoubiquitination", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327687", "species_10330261" ], "products": [ "species_10330267" ], "modifiers": [], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "ENSXETT00000057278", "Q6AZL2", "ENSXETT00000057278", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858" ] }, "reaction_10312503": { "compartment": "compartment_7660", "id": "reaction_10312503", "reactome": "R-XTR-110322", "name": "Formation of Pol zeta complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312499", "species_10312495" ], "products": [ "species_10312501" ], "modifiers": [], "additional_components": [ "ENSXETT00000102467", "ENSXETG00000027754", "A0A6I8PTL2", "ENSXETG00000027754", "Q28H85", "ENSXETT00000102467" ] }, "reaction_10326699": { "compartment": "compartment_984", "id": "reaction_10326699", "reactome": "R-XTR-2395364", "name": "LTBP4 binds TGF-Beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326673", "species_10326683" ], "products": [ "species_10326697" ], "modifiers": [], "additional_components": [ "ENSXETG00000016967", "F6SX40", "ENSXETT00000046545", "F6SX40", "ENSXETT00000046545", "A0A6I8PY10", "ENSXETG00000016967" ] }, "reaction_10326695": { "compartment": "compartment_984", "id": "reaction_10326695", "reactome": "R-XTR-2395328", "name": "LTBP1, LTBP3 bind TGF-Beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326691", "species_10326685" ], "products": [ "species_10326693" ], "modifiers": [], "additional_components": [ "F6SX40", "ENSXETT00000046545", "A0A6I8RJM7", "ENSXETG00000019349", "A0A6I8S6N3", "ENSXETG00000008431", "A0A6I8RJM7", "ENSXETG00000019349", "A0A6I8S6N3", "ENSXETG00000008431", "F6SX40", "ENSXETT00000046545" ] }, "reaction_10327034": { "compartment": "compartment_876", "id": "reaction_10327034", "reactome": "R-XTR-2731078", "name": "Syndecans 2, (4) bind TGFB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313442", "species_10325703" ], "products": [ "species_10327032" ], "modifiers": [], "additional_components": [ "ENSXETT00000046545", "ENSXETG00000035467", "A0A6I8R5Q9", "ENSXETG00000035467", "F6SX40", "ENSXETT00000046545" ] }, "reaction_10326862": { "compartment": "compartment_984", "id": "reaction_10326862", "reactome": "R-XTR-2534248", "name": "DCN (decorin) degradation by MMP2, MMP3, MMP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326665" ], "products": [ "species_10326858", "species_10326860" ], "modifiers": [ [ "species_10323712", "catalyst" ] ], "additional_components": [ "ENSXETT00000063928", "ENSXETT00000063928", "ENSXETT00000063928", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801" ] }, "reaction_10323101": { "compartment": "compartment_984", "id": "reaction_10323101", "reactome": "R-XTR-1454757", "name": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323080" ], "products": [], "modifiers": [ [ "species_10323098", "catalyst" ] ], "additional_components": [ "Q6P4Z2", "ENSXETT00000043834", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8QL61", "ENSXETG00000022198", "A0A6I8RGF4", "ENSXETG00000002801", "F6ZRF9", "ENSXETT00000037915" ] }, "reaction_10323166": { "compartment": "compartment_984", "id": "reaction_10323166", "reactome": "R-XTR-1474197", "name": "Collagen type II degradation by MMP1,3,8,13,PRSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323151" ], "products": [ "species_10322559" ], "modifiers": [ [ "species_10323163", "catalyst" ] ], "additional_components": [ "Q6P4Z2", "ENSXETT00000043834", "Q6P4Z2", "ENSXETT00000043834", "A0A6I8QL61", "ENSXETG00000022198", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801" ] }, "reaction_10326201": { "compartment": "compartment_876", "id": "reaction_10326201", "reactome": "R-XTR-2167942", "name": "Collagen type XIII ectodomain shedding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326034" ], "products": [ "species_10326177", "species_10326175" ], "modifiers": [], "additional_components": [ "A0A6I8SFH9", "ENSXETG00000037705", "ENSXETG00000037705", "A0A6I8SFH9", "ENSXETG00000037705" ] }, "reaction_10326292": { "compartment": "compartment_984", "id": "reaction_10326292", "reactome": "R-XTR-2172433", "name": "Collagen type XIX degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326290" ], "products": [], "modifiers": [], "additional_components": [ "A0A6I8SFH9", "ENSXETG00000037705" ] }, "reaction_10323715": { "compartment": "compartment_984", "id": "reaction_10323715", "reactome": "R-XTR-1564142", "name": "Collagen type IV degradation by MMP2,3,4,9,10,12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323710" ], "products": [ "species_10323078" ], "modifiers": [ [ "species_10323712", "catalyst" ] ], "additional_components": [ "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801" ] }, "reaction_10323113": { "compartment": "compartment_984", "id": "reaction_10323113", "reactome": "R-XTR-1454781", "name": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323109", "species_10312984" ], "products": [ "species_10323111" ], "modifiers": [], "additional_components": [ "A0A6I8QL61", "ENSXETG00000022198", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801", "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942", "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942", "A0A6I8QL61", "ENSXETG00000022198", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801" ] }, "reaction_10334763": { "compartment": "compartment_70101", "id": "reaction_10334763", "reactome": "R-XTR-8848658", "name": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848706" ], "products": [ "species_8848709" ], "modifiers": [ [ "species_10334760", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "F7CZN1", "ENSXETT00000006277", "species_74112", "A0A6I8QL03", "ENSXETG00000030338" ] }, "reaction_10323839": { "compartment": "compartment_984", "id": "reaction_10323839", "reactome": "R-XTR-1602488", "name": "Initial activation of proMMP13 by plasmin and trypsin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323832" ], "products": [ "species_10323834", "species_10323836" ], "modifiers": [ [ "species_10323161", "catalyst" ] ], "additional_components": [ "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148" ] }, "reaction_10323881": { "compartment": "compartment_984", "id": "reaction_10323881", "reactome": "R-XTR-1604752", "name": "Initial activation of proMMP13 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323832" ], "products": [ "species_10323855", "species_10323868" ], "modifiers": [ [ "species_10323878", "catalyst" ] ], "additional_components": [ "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801", "F6ZRF9", "ENSXETT00000037915", "A0A6I8QK05", "ENSXETG00000027581", "A0A6I8SNY4", "ENSXETG00000035558" ] }, "reaction_10323864": { "compartment": "compartment_984", "id": "reaction_10323864", "reactome": "R-XTR-1604732", "name": "Autocatalytic activation of proMMP13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323853" ], "products": [ "species_10323857", "species_10323092" ], "modifiers": [ [ "species_10323853", "catalyst" ] ], "additional_components": [ "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801" ] }, "reaction_10323851": { "compartment": "compartment_984", "id": "reaction_10323851", "reactome": "R-XTR-1604731", "name": "Autocatalytic activation of MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323764" ], "products": [ "species_10323848", "species_10323096" ], "modifiers": [ [ "species_10323764", "catalyst" ] ], "additional_components": [ "ENSXETT00000037915", "ENSXETT00000037915", "ENSXETT00000037915", "ENSXETT00000037915" ] }, "reaction_10323781": { "compartment": "compartment_984", "id": "reaction_10323781", "reactome": "R-XTR-1592371", "name": "Initial activation of proMMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323762" ], "products": [ "species_10323766", "species_10323764" ], "modifiers": [ [ "species_10323778", "catalyst" ] ], "additional_components": [ "ENSXETT00000037915", "ENSXETT00000037915", "ENSXETT00000037915", "A0A6I8S6I3", "ENSXETG00000005867", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "A0A5G3K998", "ENSXETT00000090622" ] }, "reaction_10323735": { "compartment": "compartment_984", "id": "reaction_10323735", "reactome": "R-XTR-1592297", "name": "Full activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323732" ], "products": [ "species_10323084" ], "modifiers": [ [ "species_10323712", "catalyst" ] ], "additional_components": [ "ENSXETG00000022198", "ENSXETG00000022198", "F6ZRF9", "ENSXETT00000037915", "A0A6I8RGF4", "ENSXETG00000002801" ] }, "reaction_10323830": { "compartment": "compartment_984", "id": "reaction_10323830", "reactome": "R-XTR-1602473", "name": "Autocatalytic activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323739" ], "products": [ "species_10323827", "species_10323732" ], "modifiers": [ [ "species_10323739", "catalyst" ] ], "additional_components": [ "ENSXETG00000022198", "ENSXETG00000022198", "ENSXETG00000022198", "ENSXETG00000022198" ] }, "reaction_10323846": { "compartment": "compartment_984", "id": "reaction_10323846", "reactome": "R-XTR-1604359", "name": "Initial activation of proMMP2 by MMP1, 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323841" ], "products": [ "species_10323843", "species_10323725" ], "modifiers": [ [ "species_10323084", "catalyst" ] ], "additional_components": [ "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000022198" ] }, "reaction_10323825": { "compartment": "compartment_984", "id": "reaction_10323825", "reactome": "R-XTR-1602458", "name": "Activation of proMMP10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323820" ], "products": [ "species_10323103" ], "modifiers": [ [ "species_10323822", "catalyst" ] ], "additional_components": [ "ENSXETT00000037915", "ENSXETT00000037915", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "A0A5G3K998", "ENSXETT00000090622" ] }, "reaction_10323760": { "compartment": "compartment_984", "id": "reaction_10323760", "reactome": "R-XTR-1592316", "name": "Initial activation of proMMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323737" ], "products": [ "species_10323739", "species_10323741" ], "modifiers": [ [ "species_10323757", "catalyst" ] ], "additional_components": [ "ENSXETG00000022198", "ENSXETG00000022198", "ENSXETG00000022198", "A0A6I8S6I3", "ENSXETG00000005867", "F7A271", "ENSXETT00000036622", "A0A6I8R8N0", "ENSXETG00000026148", "A0A6I8RBC3", "ENSXETG00000037351", "Q5HZU5", "ENSXETT00000093455", "A0A6I8QPJ5", "ENSXETG00000039590", "F7EHU5", "ENSXETT00000037000" ] }, "reaction_10323730": { "compartment": "compartment_984", "id": "reaction_10323730", "reactome": "R-XTR-1592278", "name": "Autocatalytic activation of proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323725" ], "products": [ "species_10323094", "species_10323727" ], "modifiers": [ [ "species_10323725", "catalyst" ] ], "additional_components": [ "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801", "ENSXETG00000002801" ] }, "reaction_10324621": { "compartment": "compartment_12045", "id": "reaction_10324621", "reactome": "R-XTR-1981104", "name": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10324614", "species_1650779" ], "products": [ "species_1650769", "species_10324618", "species_159751" ], "modifiers": [ [ "species_10324612", "catalyst" ] ], "additional_components": [ "species_435347", "F7D3M1", "ENSXETT00000023809", "species_435347", "F7D3M1", "ENSXETT00000023809", "species_435347", "F7D3M1", "ENSXETT00000023809" ] }, "reaction_10336797": { "compartment": "compartment_17957", "id": "reaction_10336797", "reactome": "R-XTR-8944250", "name": "Association of procollagen type XXV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325361" ], "products": [ "species_10325363" ], "modifiers": [], "additional_components": [ "ENSXETG00000035357", "A0A6I8STN5", "ENSXETG00000035357" ] }, "reaction_10336799": { "compartment": "compartment_17957", "id": "reaction_10336799", "reactome": "R-XTR-8944254", "name": "Association of procollagen type XXVI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325368" ], "products": [ "species_10325392" ], "modifiers": [], "additional_components": [ "ENSXETG00000035357", "A0A6I8STN5", "ENSXETG00000035357" ] }, "reaction_10336793": { "compartment": "compartment_17957", "id": "reaction_10336793", "reactome": "R-XTR-8944242", "name": "Association of procollagen type XXVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325394" ], "products": [ "species_10325418" ], "modifiers": [], "additional_components": [ "ENSXETT00000032928", "A0JP88", "ENSXETT00000032928" ] }, "reaction_10336795": { "compartment": "compartment_17957", "id": "reaction_10336795", "reactome": "R-XTR-8944246", "name": "Association of procollagen type XXI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325329" ], "products": [ "species_10325331" ], "modifiers": [], "additional_components": [ "ENSXETG00000034204", "A0A6I8RDS2", "ENSXETG00000034204" ] }, "reaction_10336805": { "compartment": "compartment_17957", "id": "reaction_10336805", "reactome": "R-XTR-8944265", "name": "Association of procollagen type IV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325154", "species_10325056", "species_10325206", "species_10325156", "species_10325182", "species_10325054" ], "products": [ "species_10325232" ], "modifiers": [], "additional_components": [ "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "ENSXETG00000001547", "ENSXETG00000001547", "ENSXETG00000001547", "ENSXETG00000001565", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565" ] }, "reaction_10336791": { "compartment": "compartment_17957", "id": "reaction_10336791", "reactome": "R-XTR-8944236", "name": "Association of procollagen type XIV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325272" ], "products": [ "species_10325298" ], "modifiers": [], "additional_components": [ "ENSXETG00000005761", "A0A6I8RGK2", "ENSXETG00000005761" ] }, "reaction_10336801": { "compartment": "compartment_17957", "id": "reaction_10336801", "reactome": "R-XTR-8944261", "name": "Association of procollagen type XIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325239" ], "products": [ "species_10325265" ], "modifiers": [], "additional_components": [ "ENSXETG00000037705", "A0A6I8SFH9", "ENSXETG00000037705" ] }, "reaction_10324656": { "compartment": "compartment_17957", "id": "reaction_10324656", "reactome": "R-XTR-2002401", "name": "Association of procollagen type XVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324628" ], "products": [ "species_10324654" ], "modifiers": [], "additional_components": [ "ENSXETT00000012721", "F6VQW0", "ENSXETT00000012721" ] }, "reaction_10336803": { "compartment": "compartment_17957", "id": "reaction_10336803", "reactome": "R-XTR-8944263", "name": "Association of procollagen type II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324956" ], "products": [ "species_10324980" ], "modifiers": [], "additional_components": [ "ENSXETT00000043834", "Q6P4Z2", "ENSXETT00000043834" ] }, "reaction_10336787": { "compartment": "compartment_17957", "id": "reaction_10336787", "reactome": "R-XTR-8944227", "name": "Association of procollagen type XXII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325336" ], "products": [ "species_10325357" ], "modifiers": [], "additional_components": [ "ENSXETG00000034204", "A0A6I8RDS2", "ENSXETG00000034204" ] }, "reaction_10326042": { "compartment": "compartment_17957", "id": "reaction_10326042", "reactome": "R-XTR-2152276", "name": "Secretion of transmembrane collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326008" ], "products": [ "species_10326040" ], "modifiers": [], "additional_components": [ "A0A6I8SFH9", "ENSXETG00000037705", "A0A6I8STN5", "ENSXETG00000035357", "A0A6I8STN5", "ENSXETG00000035357", "A0A6I8SFH9", "ENSXETG00000037705" ] }, "reaction_10326479": { "compartment": "compartment_984", "id": "reaction_10326479", "reactome": "R-XTR-2213207", "name": "Formation of collagen networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326477" ], "products": [ "species_10323710" ], "modifiers": [], "additional_components": [ "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547" ] }, "reaction_10326447": { "compartment": "compartment_984", "id": "reaction_10326447", "reactome": "R-XTR-2213201", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323205" ], "products": [ "species_10326445" ], "modifiers": [], "additional_components": [ "Q6P4Z2", "ENSXETT00000043834", "A0JP88", "ENSXETT00000032928", "Q6P4Z2", "ENSXETT00000043834", "A0JP88", "ENSXETT00000032928" ] }, "reaction_10326993": { "compartment": "compartment_984", "id": "reaction_10326993", "reactome": "R-XTR-2559639", "name": "Collagen type IV sulfilimine cross-linking by peroxidasin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_10323710" ], "products": [ "species_10326984" ], "modifiers": [ [ "species_10326990", "catalyst" ] ], "additional_components": [ "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8R6H3", "ENSXETG00000002635", "A4IGL7", "ENSXETG00000006965", "CHEBI:15858" ] }, "reaction_10323207": { "compartment": "compartment_984", "id": "reaction_10323207", "reactome": "R-XTR-1474266", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323201" ], "products": [ "species_10323205" ], "modifiers": [], "additional_components": [ "Q6P4Z2", "ENSXETT00000043834", "A0JP88", "ENSXETT00000032928", "Q6P4Z2", "ENSXETT00000043834", "A0JP88", "ENSXETT00000032928" ] }, "reaction_10326814": { "compartment": "compartment_984", "id": "reaction_10326814", "reactome": "R-XTR-2426450", "name": "Laminins:Nidogens binds collagen type IV networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326810", "species_10323710" ], "products": [ "species_10326812" ], "modifiers": [], "additional_components": [ "A0A6I8QYL3", "ENSXETG00000012279", "A0A6I8SMI4", "ENSXETG00000007336", "A0JP86", "ENSXETG00000012525", "A0A6I8RIS5", "ENSXETG00000012198", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8R6H3", "ENSXETG00000002635", "A0A6I8SI48", "ENSXETG00000001565", "A0A6I8RXV9", "ENSXETG00000001547", "A0A6I8QYL3", "ENSXETG00000012279", "A0A6I8SMI4", "ENSXETG00000007336", "A0JP86", "ENSXETG00000012525", "A0A6I8RIS5", "ENSXETG00000012198" ] }, "reaction_10336708": { "compartment": "compartment_876", "id": "reaction_10336708", "reactome": "R-XTR-8941234", "name": "SH3PXD2A binds ADAM12,ADAM15,ADAM19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10336704", "species_10336700" ], "products": [ "species_10336706" ], "modifiers": [], "additional_components": [ "ENSXETG00000034170", "species_1806238", "A0A6I8RHF6", "ENSXETG00000011399", "species_1806238", "A0A6I8RHF6", "ENSXETG00000011399", "A0A6I8PWV8", "ENSXETG00000034170" ] }, "reaction_10323437": { "compartment": "compartment_70101", "id": "reaction_10323437", "reactome": "R-XTR-1504213", "name": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10323415", "species_10323417" ], "products": [ "species_10323419" ], "modifiers": [], "additional_components": [ "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8SYH3", "ENSXETG00000025907", "A4IHP4", "ENSXETT00000017945", "B1WAP7", "ENSXETT00000037606", "Q05AS8", "ENSXETG00000017212", "B1WAP7", "ENSXETT00000037606", "Q05AS8", "ENSXETG00000017212", "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8SYH3", "ENSXETG00000025907", "A4IHP4", "ENSXETT00000017945" ] }, "reaction_10323435": { "compartment": "compartment_70101", "id": "reaction_10323435", "reactome": "R-XTR-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312116", "species_10323419" ], "products": [ "species_10323432" ], "modifiers": [ [ "species_10323419", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "B1WAP7", "ENSXETT00000037606", "Q05AS8", "ENSXETG00000017212", "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8SYH3", "ENSXETG00000025907", "A4IHP4", "ENSXETT00000017945", "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8SYH3", "ENSXETG00000025907", "A4IHP4", "ENSXETT00000017945", "Q05AS8", "ENSXETG00000017212", "B1WAP7", "ENSXETT00000037606", "B1WAP7", "ENSXETT00000037606", "Q05AS8", "ENSXETG00000017212", "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8SYH3", "ENSXETG00000025907", "A4IHP4", "ENSXETT00000017945" ] }, "reaction_10328747": { "compartment": "compartment_70101", "id": "reaction_10328747", "reactome": "R-XTR-4641147", "name": "DACT1 binds DVL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328743", "species_10315690" ], "products": [ "species_10328745" ], "modifiers": [], "additional_components": [ "ENSXETG00000011962", "ENSXETG00000017212", "Q05AS8", "ENSXETG00000017212", "Q66KC9", "ENSXETG00000011962" ] }, "reaction_10328777": { "compartment": "compartment_876", "id": "reaction_10328777", "reactome": "R-XTR-4641246", "name": "ZNRF3 autoubiquitinates to promote its internalization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312116", "species_10328767" ], "products": [ "species_10328774" ], "modifiers": [ [ "species_10328767", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q08D68", "ENSXETT00000070371", "Q5M7L6", "ENSXETT00000065307", "A0A6I8PSP2", "ENSXETG00000030823", "Q08D68", "ENSXETT00000070371", "Q5M7L6", "ENSXETT00000065307", "A0A6I8PSP2", "ENSXETG00000030823", "Q08D68", "ENSXETT00000070371", "Q5M7L6", "ENSXETT00000065307", "A0A6I8PSP2", "ENSXETG00000030823" ] }, "reaction_10328795": { "compartment": "compartment_876", "id": "reaction_10328795", "reactome": "R-XTR-4641253", "name": "ZNRF3 ubiquitinates FZD to promote its downregulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328787", "species_10312116" ], "products": [ "species_10328792" ], "modifiers": [ [ "species_10328787", "catalyst" ] ], "additional_components": [ "Q08D68", "ENSXETT00000070371", "A0A6I8QRN7", "ENSXETG00000034910", "A0A6I8S584", "ENSXETG00000008917", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q08D68", "ENSXETT00000070371", "A0A6I8QRN7", "ENSXETG00000034910", "A0A6I8S584", "ENSXETG00000008917", "Q08D68", "ENSXETT00000070371", "A0A6I8QRN7", "ENSXETG00000034910", "A0A6I8S584", "ENSXETG00000008917" ] }, "reaction_10328769": { "compartment": "compartment_876", "id": "reaction_10328769", "reactome": "R-XTR-4641205", "name": "RSPO:LGR binds ZNRF3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328761", "species_10328765" ], "products": [ "species_10328767" ], "modifiers": [], "additional_components": [ "Q5M7L6", "ENSXETT00000065307", "A0A6I8PSP2", "ENSXETG00000030823", "ENSXETT00000070371", "Q08D68", "ENSXETT00000070371", "Q5M7L6", "ENSXETT00000065307", "A0A6I8PSP2", "ENSXETG00000030823" ] }, "reaction_10335855": { "compartment": "compartment_12045", "id": "reaction_10335855", "reactome": "R-XTR-8869206", "name": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8869214" ], "products": [ "species_29416", "species_8869207" ], "modifiers": [ [ "species_10335852", "catalyst" ] ], "additional_components": [ "ENSXETG00000040379" ] }, "reaction_10317819": { "compartment": "compartment_984", "id": "reaction_10317819", "reactome": "R-XTR-419490", "name": "Binding of ATP to P2X receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114570", "species_10312780" ], "products": [ "species_10312782" ], "modifiers": [], "additional_components": [ "ENSXETG00000041261", "A0A6I8S619", "ENSXETG00000041261", "species_113593" ] }, "reaction_10312785": { "compartment": "compartment_876", "id": "reaction_10312785", "reactome": "R-XTR-139855", "name": "P2X1-mediated entry of Ca++ from plasma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10312782", "catalyst" ] ], "additional_components": [ "A0A6I8S619", "ENSXETG00000041261", "species_113593" ] }, "reaction_10317725": { "compartment": "compartment_114521", "id": "reaction_10317725", "reactome": "R-XTR-418365", "name": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427899", "species_74016" ], "products": [ "species_70106", "species_139827" ], "modifiers": [ [ "species_10317722", "catalyst" ] ], "additional_components": [ "A0A6I8Q1N1", "ENSXETG00000002512", "A0A6I8RIR9", "ENSXETG00000009695" ] }, "reaction_10317712": { "compartment": "compartment_876", "id": "reaction_10317712", "reactome": "R-XTR-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10317709", "catalyst" ] ], "additional_components": [ "ENSXETG00000000441" ] }, "reaction_10328380": { "compartment": "compartment_70101", "id": "reaction_10328380", "reactome": "R-XTR-3928578", "name": "EPH receptors autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10328363" ], "products": [ "species_29370", "species_10328377" ], "modifiers": [ [ "species_10328363", "catalyst" ] ], "additional_components": [ "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R4R5", "ENSXETG00000017584", "A0A6I8R3N5", "ENSXETG00000018746", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584" ] }, "reaction_10328388": { "compartment": "compartment_876", "id": "reaction_10328388", "reactome": "R-XTR-3928646", "name": "EPHAs bind EFNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328359", "species_10328349" ], "products": [ "species_10328361" ], "modifiers": [], "additional_components": [ "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584" ] }, "reaction_10328519": { "compartment": "compartment_876", "id": "reaction_10328519", "reactome": "R-XTR-4093342", "name": "SDC2 multimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328515" ], "products": [ "species_10328517" ], "modifiers": [], "additional_components": [ "ENSXETG00000035467", "A0A6I8R5Q9", "ENSXETG00000035467" ] }, "reaction_10328384": { "compartment": "compartment_876", "id": "reaction_10328384", "reactome": "R-XTR-3928591", "name": "EPH:EFN tetramers oligomerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328361", "species_10328382" ], "products": [ "species_10328363" ], "modifiers": [], "additional_components": [ "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584" ] }, "reaction_10328386": { "compartment": "compartment_876", "id": "reaction_10328386", "reactome": "R-XTR-3928597", "name": "EPH:EFN dimers tetramerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328361" ], "products": [ "species_10328382" ], "modifiers": [], "additional_components": [ "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584", "F6TBR2", "ENSXETT00000007111", "A0A6I8SYQ8", "ENSXETG00000039321", "A0A6I8R3N5", "ENSXETG00000018746", "A0A6I8R4R5", "ENSXETG00000017584" ] }, "reaction_10313950": { "compartment": "compartment_70101", "id": "reaction_10313950", "reactome": "R-XTR-183036", "name": "Ubiquitination of stimulated EGFR (CBL:GRB2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312116", "species_10313941" ], "products": [ "species_10313947" ], "modifiers": [ [ "species_10313941", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "Q66II3", "ENSXETT00000027387", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "Q66II3", "ENSXETT00000027387", "F7C8B9", "ENSXETT00000006761", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "Q66II3", "ENSXETT00000027387", "F7C8B9", "ENSXETT00000006761" ] }, "reaction_10313975": { "compartment": "compartment_70101", "id": "reaction_10313975", "reactome": "R-XTR-183058", "name": "Phosphorylation of CBL (EGFR:GRB2:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10313972" ], "products": [ "species_29370", "species_10313941" ], "modifiers": [ [ "species_10313972", "catalyst" ] ], "additional_components": [ "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "Q66II3", "ENSXETT00000027387", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10313968": { "compartment": "compartment_70101", "id": "reaction_10313968", "reactome": "R-XTR-183051", "name": "CBL ubiquitinates Sprouty", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312116", "species_10313961" ], "products": [ "species_10313965" ], "modifiers": [ [ "species_10313961", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8SCT0", "ENSXETG00000041240", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8SCT0", "ENSXETG00000041240", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8SCT0", "ENSXETG00000041240" ] }, "reaction_10313903": { "compartment": "compartment_70101", "id": "reaction_10313903", "reactome": "R-XTR-177934", "name": "EGFR autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313842", "species_113592" ], "products": [ "species_29370", "species_10313869" ], "modifiers": [ [ "species_10313842", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877" ] }, "reaction_10313900": { "compartment": "compartment_70101", "id": "reaction_10313900", "reactome": "R-XTR-177930", "name": "GAB1 phosphorylation by EGFR kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10313892" ], "products": [ "species_29370", "species_10313871" ], "modifiers": [ [ "species_10313892", "catalyst" ] ], "additional_components": [ "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838" ] }, "reaction_10313886": { "compartment": "compartment_70101", "id": "reaction_10313886", "reactome": "R-XTR-177924", "name": "Dephosphorylation of Gab1 by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10313873" ], "products": [ "species_29372", "species_10313883" ], "modifiers": [ [ "species_10313873", "catalyst" ] ], "additional_components": [ "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838" ] }, "reaction_10313913": { "compartment": "compartment_70101", "id": "reaction_10313913", "reactome": "R-XTR-177935", "name": "SHP2 dephosphorylates Tyr 992 on EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10313873" ], "products": [ "species_29372", "species_10313911" ], "modifiers": [ [ "species_10313873", "catalyst" ] ], "additional_components": [ "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838" ] }, "reaction_10313816": { "compartment": "compartment_70101", "id": "reaction_10313816", "reactome": "R-XTR-177920", "name": "Binding of GRB2 to GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313812", "species_10312043" ], "products": [ "species_10313814" ], "modifiers": [], "additional_components": [ "ENSXETT00000038110", "ENSXETT00000027387", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110" ] }, "reaction_10313924": { "compartment": "compartment_70101", "id": "reaction_10313924", "reactome": "R-XTR-177941", "name": "GRB2:GAB1 binds to phosphorylated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313890", "species_10313869" ], "products": [ "species_10313892" ], "modifiers": [], "additional_components": [ "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838" ] }, "reaction_10313937": { "compartment": "compartment_70101", "id": "reaction_10313937", "reactome": "R-XTR-179467", "name": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10313814" ], "products": [ "species_10313888" ], "modifiers": [], "additional_components": [ "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "species_179838" ] }, "reaction_10313922": { "compartment": "compartment_70101", "id": "reaction_10313922", "reactome": "R-XTR-177939", "name": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10313919", "catalyst" ] ], "additional_components": [ "A0A6I8RUB1", "ENSXETG00000007252", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "C0IMZ9", "ENSXETT00000038110", "Q66II3", "ENSXETT00000027387", "species_179838" ] }, "reaction_10313930": { "compartment": "compartment_984", "id": "reaction_10313930", "reactome": "R-XTR-177942", "name": "EGFR binds EGF ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313838", "species_10313820" ], "products": [ "species_10313840" ], "modifiers": [ [ "species_10313928", "inhibitor" ] ], "additional_components": [ "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "ENSXETT00000006761", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "ENSXETT00000017426" ] }, "reaction_10313844": { "compartment": "compartment_876", "id": "reaction_10313844", "reactome": "R-XTR-177922", "name": "EGFR dimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313840" ], "products": [ "species_10313842" ], "modifiers": [], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877" ] }, "reaction_10313935": { "compartment": "compartment_70101", "id": "reaction_10313935", "reactome": "R-XTR-177943", "name": "GRB2:SOS1 complex binds to EGF:EGFR complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312049", "species_10313869" ], "products": [ "species_10313933" ], "modifiers": [], "additional_components": [ "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "A0A6I8QCY1", "ENSXETG00000039798", "A0A6I8SIL3", "ENSXETG00000031904", "F7AYD2", "ENSXETT00000010416", "F7CWY4", "ENSXETT00000011877", "F7C8B9", "ENSXETT00000006761", "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10312326": { "compartment": "compartment_70101", "id": "reaction_10312326", "reactome": "R-XTR-109813", "name": "GRB2-1 binds SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312043", "species_10312047" ], "products": [ "species_10312049" ], "modifiers": [], "additional_components": [ "ENSXETT00000027387", "ENSXETT00000044021", "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10314255": { "compartment": "compartment_984", "id": "reaction_10314255", "reactome": "R-XTR-192475", "name": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10314252", "catalyst" ] ], "additional_components": [ "F6ZWX1", "ENSXETT00000007508" ] }, "reaction_10337016": { "compartment": "compartment_984", "id": "reaction_10337016", "reactome": "R-XTR-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10337013", "catalyst" ] ], "additional_components": [] }, "reaction_10314244": { "compartment": "compartment_984", "id": "reaction_10314244", "reactome": "R-XTR-192434", "name": "Digestion of diacylglycerols by extracellular PTL:colipase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_174675" ], "products": [ "species_6814795", "species_174602" ], "modifiers": [ [ "species_10314239", "catalyst" ] ], "additional_components": [ "F6ZWX1", "ENSXETT00000007508" ] }, "reaction_10314242": { "compartment": "compartment_984", "id": "reaction_10314242", "reactome": "R-XTR-192422", "name": "Digestion of triacylglycerols by extracellular PTL:colipase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10314239", "catalyst" ] ], "additional_components": [ "F6ZWX1", "ENSXETT00000007508" ] }, "reaction_10329311": { "compartment": "compartment_7660", "id": "reaction_10329311", "reactome": "R-XTR-5218952", "name": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10327320" ], "products": [ "species_77502", "species_10329304" ], "modifiers": [ [ "species_10329308", "catalyst" ] ], "additional_components": [ "ENSXETG00000006676" ] }, "reaction_10329214": { "compartment": "compartment_7660", "id": "reaction_10329214", "reactome": "R-XTR-5205867", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10329171" ], "products": [ "species_77502", "species_10329211" ], "modifiers": [ [ "species_10327331", "catalyst" ] ], "additional_components": [ "ENSXETT00000094658" ] }, "reaction_10329098": { "compartment": "compartment_7660", "id": "reaction_10329098", "reactome": "R-XTR-5205820", "name": "PRMT6 methylates arginine-4 of histone H2A (H2AR3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10329055" ], "products": [ "species_77502", "species_10329095" ], "modifiers": [ [ "species_10329010", "catalyst" ] ], "additional_components": [ "ENSXETG00000009939" ] }, "reaction_10329429": { "compartment": "compartment_7660", "id": "reaction_10329429", "reactome": "R-XTR-5229203", "name": "PRMT6 methylates histone H2A arginine-30 (H2AR29)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10329387" ], "products": [ "species_77502", "species_10329427" ], "modifiers": [ [ "species_10329010", "catalyst" ] ], "additional_components": [ "ENSXETG00000009939" ] }, "reaction_10329124": { "compartment": "compartment_7660", "id": "reaction_10329124", "reactome": "R-XTR-5205824", "name": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10329112" ], "products": [ "species_77502", "species_10329122" ], "modifiers": [ [ "species_10329010", "catalyst" ] ], "additional_components": [ "ENSXETG00000009939" ] }, "reaction_10329015": { "compartment": "compartment_7660", "id": "reaction_10329015", "reactome": "R-XTR-5205798", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313794", "species_77087" ], "products": [ "species_77502", "species_10329006" ], "modifiers": [ [ "species_10329012", "catalyst" ] ], "additional_components": [ "ENSXETG00000035354", "ENSXETG00000035354", "Q28F07", "ENSXETT00000094658", "B0JYW5", "ENSXETG00000009939" ] }, "reaction_10330343": { "compartment": "compartment_7660", "id": "reaction_10330343", "reactome": "R-XTR-5661126", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10329006" ], "products": [ "species_77502", "species_10330341" ], "modifiers": [ [ "species_10329012", "catalyst" ] ], "additional_components": [ "ENSXETG00000035354", "ENSXETG00000035354", "Q28F07", "ENSXETT00000094658", "B0JYW5", "ENSXETG00000009939" ] }, "reaction_10329334": { "compartment": "compartment_7660", "id": "reaction_10329334", "reactome": "R-XTR-5225649", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316471", "species_10327320" ], "products": [ "species_10329332" ], "modifiers": [ [ "species_10329304", "inhibitor" ] ], "additional_components": [ "ENSXETT00000002157", "Q6P315", "ENSXETT00000002157" ] }, "reaction_10329330": { "compartment": "compartment_7660", "id": "reaction_10329330", "reactome": "R-XTR-5225602", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329304", "species_10329326" ], "products": [ "species_10329328" ], "modifiers": [], "additional_components": [ "ENSXETT00000102075", "Q5M786", "ENSXETT00000102075" ] }, "reaction_10326338": { "compartment": "compartment_70101", "id": "reaction_10326338", "reactome": "R-XTR-2176452", "name": "Degradation of ubiquitinated SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326336" ], "products": [], "modifiers": [], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "Q07G47", "ENSXETT00000061335" ] }, "reaction_10337420": { "compartment": "compartment_876", "id": "reaction_10337420", "reactome": "R-XTR-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337392", "species_10337416" ], "products": [ "species_10337418" ], "modifiers": [], "additional_components": [ "B1H300", "ENSXETT00000065865", "species_29438", "A0A6I8SQB3", "ENSXETG00000005314", "A0A6I8SBQ3", "ENSXETG00000021139", "A0A6I8T271", "ENSXETG00000011808", "A0A6I8SQB3", "ENSXETG00000005314", "A0A6I8SBQ3", "ENSXETG00000021139", "A0A6I8T271", "ENSXETG00000011808", "B1H300", "ENSXETT00000065865", "species_29438" ] }, "reaction_10337396": { "compartment": "compartment_876", "id": "reaction_10337396", "reactome": "R-XTR-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337392", "species_10337345" ], "products": [ "species_10337394" ], "modifiers": [], "additional_components": [ "B1H300", "ENSXETT00000065865", "species_29438", "ENSXETT00000020510", "F7D6Y2", "ENSXETT00000020510", "B1H300", "ENSXETT00000065865", "species_29438" ] }, "reaction_10337398": { "compartment": "compartment_876", "id": "reaction_10337398", "reactome": "R-XTR-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10337390" ], "products": [ "species_10337392" ], "modifiers": [], "additional_components": [ "ENSXETT00000065865", "B1H300", "ENSXETT00000065865", "species_29438" ] }, "reaction_10319096": { "compartment": "compartment_20699", "id": "reaction_10319096", "reactome": "R-XTR-744230", "name": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_744239" ], "products": [ "species_113578", "species_744233" ], "modifiers": [ [ "species_10319093", "catalyst" ] ], "additional_components": [ "ENSXETG00000041312" ] }, "reaction_10312321": { "compartment": "compartment_70101", "id": "reaction_10312321", "reactome": "R-XTR-109538", "name": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737", "species_74113" ], "products": [ "species_179743", "species_83910" ], "modifiers": [ [ "species_10312318", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_8857850", "CHEBI:17562", "species_8857850", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "ENSXETG00000011724" ] }, "reaction_10329473": { "compartment": "compartment_5460", "id": "reaction_10329473", "reactome": "R-XTR-5250210", "name": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329471" ], "products": [ "species_10329463" ], "modifiers": [], "additional_components": [ "Q5FW25", "ENSXETT00000039869", "F7BJL3", "ENSXETT00000003496", "species_29438", "Q5FW25", "ENSXETT00000039869", "F7BJL3", "ENSXETT00000003496", "species_29438" ] }, "reaction_10329475": { "compartment": "compartment_70101", "id": "reaction_10329475", "reactome": "R-XTR-5250217", "name": "ARL2:GTP binds ARL2BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329467", "species_10329469" ], "products": [ "species_10329471" ], "modifiers": [], "additional_components": [ "F7BJL3", "ENSXETT00000003496", "species_29438", "ENSXETT00000039869", "Q5FW25", "ENSXETT00000039869", "F7BJL3", "ENSXETT00000003496", "species_29438" ] }, "reaction_10316666": { "compartment": "compartment_984", "id": "reaction_10316666", "reactome": "R-XTR-349657", "name": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316664", "species_171095", "species_171142" ], "products": [ "species_10316576" ], "modifiers": [], "additional_components": [ "A0A6I8PU04", "ENSXETG00000033423", "species_163579", "species_171142", "species_216762", "A0A6I8PU04", "ENSXETG00000033423", "species_171142", "species_216762" ] }, "reaction_10316578": { "compartment": "compartment_984", "id": "reaction_10316578", "reactome": "R-XTR-216756", "name": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171095", "species_171142", "species_10313516" ], "products": [ "species_10316576" ], "modifiers": [], "additional_components": [ "ENSXETG00000033423", "A0A6I8PU04", "ENSXETG00000033423", "species_171142", "species_216762" ] }, "reaction_10312324": { "compartment": "compartment_70101", "id": "reaction_10312324", "reactome": "R-XTR-109699", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10312070", "catalyst" ] ], "additional_components": [ "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252", "A0A6I8RAF1", "ENSXETG00000039550" ] }, "reaction_10312072": { "compartment": "compartment_70101", "id": "reaction_10312072", "reactome": "R-XTR-74737", "name": "p-Y-IRS1,p-Y-IRS2 bind PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312054", "species_10312068" ], "products": [ "species_10312070" ], "modifiers": [], "additional_components": [ "ENSXETG00000039550", "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252", "A0A6I8Q186", "ENSXETG00000012933", "A0A6I8RUB1", "ENSXETG00000007252", "A0A6I8RAF1", "ENSXETG00000039550" ] }, "reaction_10312058": { "compartment": "compartment_70101", "id": "reaction_10312058", "reactome": "R-XTR-74736", "name": "GRB2-1:SOS1 binds p-IRS1,p-IRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312049", "species_10312054" ], "products": [ "species_10312056" ], "modifiers": [], "additional_components": [ "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387", "ENSXETG00000039550", "A0A6I8RAF1", "ENSXETG00000039550", "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10316221": { "compartment": "compartment_7660", "id": "reaction_10316221", "reactome": "R-XTR-211207", "name": "Cleaved fragments of DFF45 dissociate from DFF40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316198" ], "products": [ "species_10316194", "species_10316196", "species_10316184", "species_10316188" ], "modifiers": [], "additional_components": [ "F6TTW7", "ENSXETT00000013820", "F7EHJ0", "ENSXETT00000013293", "ENSXETT00000013820", "ENSXETT00000013820", "ENSXETT00000013293", "ENSXETT00000013820" ] }, "reaction_10316223": { "compartment": "compartment_13231", "id": "reaction_10316223", "reactome": "R-XTR-211219", "name": "Translocation of caspase-3 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312650" ], "products": [ "species_10316206" ], "modifiers": [], "additional_components": [ "A0A6I8PZK4", "ENSXETG00000030678", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10316219": { "compartment": "compartment_7660", "id": "reaction_10316219", "reactome": "R-XTR-211193", "name": "Homodimerization of DFF40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316184" ], "products": [ "species_10316217" ], "modifiers": [], "additional_components": [ "ENSXETT00000013293", "F7EHJ0", "ENSXETT00000013293" ] }, "reaction_10316346": { "compartment": "compartment_7660", "id": "reaction_10316346", "reactome": "R-XTR-211247", "name": "Cleavage of DNA by DFF40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316339" ], "products": [ "species_10316337", "species_10316343" ], "modifiers": [ [ "species_10316339", "catalyst" ] ], "additional_components": [ "Q6NVM0", "ENSXETT00000101169", "F7EHJ0", "ENSXETT00000013293", "F7EHJ0", "ENSXETT00000013293", "Q6NVM0", "ENSXETT00000101169", "Q6NVM0", "ENSXETT00000101169", "F7EHJ0", "ENSXETT00000013293" ] }, "reaction_10316341": { "compartment": "compartment_7660", "id": "reaction_10316341", "reactome": "R-XTR-211239", "name": "Association of DFF40 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316337", "species_10316333" ], "products": [ "species_10316339" ], "modifiers": [], "additional_components": [ "F7EHJ0", "ENSXETT00000013293", "Q6NVM0", "ENSXETT00000101169", "Q6NVM0", "ENSXETT00000101169", "F7EHJ0", "ENSXETT00000013293" ] }, "reaction_10316231": { "compartment": "compartment_70101", "id": "reaction_10316231", "reactome": "R-XTR-211224", "name": "Association of DFF40 with DFF45", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316227", "species_10316225" ], "products": [ "species_10316229" ], "modifiers": [], "additional_components": [ "ENSXETT00000013293", "ENSXETT00000013820", "F6TTW7", "ENSXETT00000013820", "F7EHJ0", "ENSXETT00000013293" ] }, "reaction_10316215": { "compartment": "compartment_7660", "id": "reaction_10316215", "reactome": "R-XTR-211190", "name": "Caspase 3-mediated cleavage of DFF45 (117)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316213" ], "products": [ "species_10316192" ], "modifiers": [ [ "species_10316206", "catalyst" ] ], "additional_components": [ "F7EHJ0", "ENSXETT00000013293", "F6TTW7", "ENSXETT00000013820", "F6TTW7", "ENSXETT00000013820", "F7EHJ0", "ENSXETT00000013293", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10316209": { "compartment": "compartment_70101", "id": "reaction_10316209", "reactome": "R-XTR-211186", "name": "Cleavage of DFF45 (224) by caspase-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316192" ], "products": [ "species_10316198" ], "modifiers": [ [ "species_10316206", "catalyst" ] ], "additional_components": [ "F6TTW7", "ENSXETT00000013820", "F7EHJ0", "ENSXETT00000013293", "F6TTW7", "ENSXETT00000013820", "F7EHJ0", "ENSXETT00000013293", "A0A6I8PZK4", "ENSXETG00000030678" ] }, "reaction_10316073": { "compartment": "compartment_70101", "id": "reaction_10316073", "reactome": "R-XTR-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10316042" ], "products": [ "species_29420", "species_10316044" ], "modifiers": [ [ "species_10316070", "catalyst" ] ], "additional_components": [ "species_29420", "Q6GL60", "ENSXETT00000092508", "Q6GL60", "ENSXETT00000092508", "species_29438", "A0A6I8QGS5", "ENSXETG00000038787", "F7DKF6", "ENSXETT00000044021", "A4II46", "ENSXETT00000074782", "A0A6I8Q734", "ENSXETG00000009131", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10316650": { "compartment": "compartment_984", "id": "reaction_10316650", "reactome": "R-XTR-265456", "name": "NPC1L1 inactivation by ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316646", "species_265479" ], "products": [ "species_10316648" ], "modifiers": [], "additional_components": [ "ENSXETG00000019001", "species_265479", "A0A6I8Q9Y0", "ENSXETG00000019001" ] }, "reaction_10330543": { "compartment": "compartment_70101", "id": "reaction_10330543", "reactome": "R-XTR-5675470", "name": "BIRC2/3 (cIAP1/2) is autoubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330519", "species_10329611" ], "products": [ "species_10330540" ], "modifiers": [ [ "species_10329611", "catalyst" ] ], "additional_components": [ "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8QAZ5", "ENSXETG00000039278", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8QAZ5", "ENSXETG00000039278", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8SGM4", "ENSXETG00000022183", "A0A6I8SZB7", "ENSXETG00000039278", "A0A6I8QUK4", "ENSXETG00000039278", "A0A6I8QAZ5", "ENSXETG00000039278" ] }, "reaction_10338143": { "compartment": "compartment_70101", "id": "reaction_10338143", "reactome": "R-XTR-9688831", "name": "STUB1 ubiquitinates RIPK3 at K55, K363", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338134", "species_10312116" ], "products": [ "species_10338140" ], "modifiers": [ [ "species_10338134", "catalyst" ] ], "additional_components": [ "A0A6I8QJD3", "ENSXETG00000038971", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A0A6I8QJD3", "ENSXETG00000038971", "A0A6I8QJD3", "ENSXETG00000038971" ] }, "reaction_10338120": { "compartment": "compartment_876", "id": "reaction_10338120", "reactome": "R-XTR-9686930", "name": "RIPK3 is cleaved by CASP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338114" ], "products": [ "species_10338118", "species_10338116" ], "modifiers": [ [ "species_10316682", "catalyst" ] ], "additional_components": [ "ENSXETG00000038971", "ENSXETG00000038971", "ENSXETG00000038971", "A0A6I8Q0P2", "ENSXETG00000032748" ] }, "reaction_10338145": { "compartment": "compartment_70101", "id": "reaction_10338145", "reactome": "R-XTR-9688838", "name": "RIPK3 binds STUB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338114", "species_10338132" ], "products": [ "species_10338134" ], "modifiers": [], "additional_components": [ "ENSXETG00000038971", "A0A6I8QJD3", "ENSXETG00000038971" ] }, "reaction_10338130": { "compartment": "compartment_70101", "id": "reaction_10338130", "reactome": "R-XTR-9687828", "name": "O-GlcNAcylation of RIPK3 (TLR4 signaling)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338114", "species_162756" ], "products": [ "species_10338123", "species_110096" ], "modifiers": [ [ "species_10338127", "catalyst" ] ], "additional_components": [ "ENSXETG00000038971", "ENSXETG00000038971", "ENSXETT00000034743" ] }, "reaction_10318991": { "compartment": "compartment_17906", "id": "reaction_10318991", "reactome": "R-XTR-508162", "name": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318987", "species_10312812" ], "products": [ "species_10318989" ], "modifiers": [], "additional_components": [ "ENSXETT00000050759", "ENSXETG00000031875", "A0A6I8PXS6", "ENSXETG00000031875", "F6XC18", "ENSXETT00000050759" ] }, "reaction_10312680": { "compartment": "compartment_17906", "id": "reaction_10312680", "reactome": "R-XTR-114263", "name": "Oligomerization of BAK at the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312676" ], "products": [ "species_10312678" ], "modifiers": [], "additional_components": [ "ENSXETG00000038338", "A0A6I8QFQ5", "ENSXETG00000038338" ] }, "reaction_10312692": { "compartment": "compartment_17906", "id": "reaction_10312692", "reactome": "R-XTR-114275", "name": "Oligomerization of BAX at the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312686" ], "products": [ "species_10312690" ], "modifiers": [], "additional_components": [ "ENSXETT00000031936", "F6TEC3", "ENSXETT00000031936" ] }, "reaction_10312688": { "compartment": "compartment_70101", "id": "reaction_10312688", "reactome": "R-XTR-114264", "name": "Translocation of activated BAX to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312684" ], "products": [ "species_10312686" ], "modifiers": [], "additional_components": [ "ENSXETT00000031936", "ENSXETT00000031936" ] }, "reaction_10312412": { "compartment": "compartment_7660", "id": "reaction_10312412", "reactome": "R-XTR-110218", "name": "Cleavage of uracil by TDG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312407" ], "products": [ "species_10312409", "species_29554" ], "modifiers": [ [ "species_10312407", "catalyst" ] ], "additional_components": [ "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927" ] }, "reaction_10312428": { "compartment": "compartment_7660", "id": "reaction_10312428", "reactome": "R-XTR-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312423" ], "products": [ "species_110223", "species_10312425" ], "modifiers": [ [ "species_10312423", "catalyst" ] ], "additional_components": [ "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540" ] }, "reaction_10312476": { "compartment": "compartment_7660", "id": "reaction_10312476", "reactome": "R-XTR-110234", "name": "Cleavage of ethenocytosine by TDG glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312473" ], "products": [ "species_110233", "species_10312409" ], "modifiers": [ [ "species_10312473", "catalyst" ] ], "additional_components": [ "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927" ] }, "reaction_10312398": { "compartment": "compartment_7660", "id": "reaction_10312398", "reactome": "R-XTR-110215", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312391" ], "products": [ "species_10312395", "species_29554" ], "modifiers": [ [ "species_10312391", "catalyst" ] ], "additional_components": [ "F6V364", "ENSXETT00000048248", "F6V364", "ENSXETT00000048248", "F6V364", "ENSXETT00000048248" ] }, "reaction_10312462": { "compartment": "compartment_7660", "id": "reaction_10312462", "reactome": "R-XTR-110231", "name": "Cleavage of uracil by MBD4 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312457" ], "products": [ "species_10312459", "species_29554" ], "modifiers": [ [ "species_10312457", "catalyst" ] ], "additional_components": [ "A0A6I8PM79", "ENSXETG00000026622", "A0A6I8PM79", "ENSXETG00000026622", "A0A6I8PM79", "ENSXETG00000026622" ] }, "reaction_10312442": { "compartment": "compartment_7660", "id": "reaction_10312442", "reactome": "R-XTR-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312439" ], "products": [ "species_30140", "species_10312425" ], "modifiers": [ [ "species_10312439", "catalyst" ] ], "additional_components": [ "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540" ] }, "reaction_10312405": { "compartment": "compartment_7660", "id": "reaction_10312405", "reactome": "R-XTR-110217", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312402" ], "products": [ "species_110216", "species_10312395" ], "modifiers": [ [ "species_10312402", "catalyst" ] ], "additional_components": [ "F6V364", "ENSXETT00000048248", "F6V364", "ENSXETT00000048248", "F6V364", "ENSXETT00000048248" ] }, "reaction_10312469": { "compartment": "compartment_7660", "id": "reaction_10312469", "reactome": "R-XTR-110232", "name": "Cleavage of thymine by MBD4 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312466" ], "products": [ "species_29692", "species_10312459" ], "modifiers": [ [ "species_10312466", "catalyst" ] ], "additional_components": [ "A0A6I8PM79", "ENSXETG00000026622", "A0A6I8PM79", "ENSXETG00000026622", "A0A6I8PM79", "ENSXETG00000026622" ] }, "reaction_10330164": { "compartment": "compartment_7660", "id": "reaction_10330164", "reactome": "R-XTR-5649681", "name": "NEIL2 cleaves 5-OHU from damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330159" ], "products": [ "species_10330161", "species_110216" ], "modifiers": [ [ "species_10330159", "catalyst" ] ], "additional_components": [ "F7D0D2", "ENSXETT00000051487", "F7D0D2", "ENSXETT00000051487", "F7D0D2", "ENSXETT00000051487" ] }, "reaction_10312449": { "compartment": "compartment_7660", "id": "reaction_10312449", "reactome": "R-XTR-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312446" ], "products": [ "species_5637659", "species_10312425" ], "modifiers": [ [ "species_10312446", "catalyst" ] ], "additional_components": [ "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540" ] }, "reaction_10312419": { "compartment": "compartment_7660", "id": "reaction_10312419", "reactome": "R-XTR-110219", "name": "Cleavage of thymine by TDG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312416" ], "products": [ "species_29692", "species_10312409" ], "modifiers": [ [ "species_10312416", "catalyst" ] ], "additional_components": [ "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927" ] }, "reaction_10312435": { "compartment": "compartment_7660", "id": "reaction_10312435", "reactome": "R-XTR-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312432" ], "products": [ "species_10312425", "species_110225" ], "modifiers": [ [ "species_10312432", "catalyst" ] ], "additional_components": [ "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540", "A0A6I8R4X6", "ENSXETG00000035540" ] }, "reaction_10316654": { "compartment": "compartment_984", "id": "reaction_10316654", "reactome": "R-XTR-266089", "name": "Discoidal HDL binds membrane-associated free cholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316576", "species_171095" ], "products": [ "species_10316652" ], "modifiers": [], "additional_components": [ "A0A6I8PU04", "ENSXETG00000033423", "species_171142", "species_216762", "A0A6I8PU04", "ENSXETG00000033423", "species_171142", "species_216762" ] }, "reaction_10316660": { "compartment": "compartment_984", "id": "reaction_10316660", "reactome": "R-XTR-266299", "name": "Spherical HDL binds membrane-associated free cholesterol and phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316656", "species_171095", "species_171142" ], "products": [ "species_10316658" ], "modifiers": [], "additional_components": [ "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "species_171142", "species_216762", "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "species_171142", "species_216762" ] }, "reaction_10331331": { "compartment": "compartment_984", "id": "reaction_10331331", "reactome": "R-XTR-5694109", "name": "LIPC dimer hydrolyses TAG to DAG and FA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_422024", "species_174675" ], "modifiers": [ [ "species_10331328", "catalyst" ] ], "additional_components": [ "species_1604784" ] }, "reaction_10332258": { "compartment": "compartment_984", "id": "reaction_10332258", "reactome": "R-XTR-6785213", "name": "LIPC dimer binds heparin", "reversible": "false", "notes": "", "reactants": [ "species_1604784", "species_10331326" ], "products": [ "species_10331328" ], "modifiers": [], "additional_components": [ "species_1604784" ] }, "reaction_10313538": { "compartment": "compartment_984", "id": "reaction_10313538", "reactome": "R-XTR-174739", "name": "chylomicron remnant + apoE => chylomicron remnant:apoE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313530", "species_10313532" ], "products": [ "species_10313534" ], "modifiers": [], "additional_components": [ "ENSXETT00000100802", "species_171126", "species_163579", "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "Q6P615", "ENSXETT00000100802", "species_216762", "species_171126", "species_163579", "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "Q6P615", "ENSXETT00000100802", "species_216762" ] }, "reaction_10317772": { "compartment": "compartment_204883", "id": "reaction_10317772", "reactome": "R-XTR-419001", "name": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140648", "species_10317768" ], "products": [ "species_10317770" ], "modifiers": [], "additional_components": [ "A0A6I8SWY9", "ENSXETG00000011269", "A0A6I8RR45", "ENSXETG00000020131", "F6XNI3", "ENSXETT00000034059", "A0A6I8SWY9", "ENSXETG00000011269", "A0A6I8RR45", "ENSXETG00000020131", "F6XNI3", "ENSXETT00000034059" ] }, "reaction_10318171": { "compartment": "compartment_876", "id": "reaction_10318171", "reactome": "R-XTR-433711", "name": "Cis-homodimerization of nectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317776" ], "products": [ "species_10317778" ], "modifiers": [], "additional_components": [ "ENSXETT00000020211", "F7E015", "ENSXETT00000020211" ] }, "reaction_10317893": { "compartment": "compartment_204883", "id": "reaction_10317893", "reactome": "R-XTR-420593", "name": "PVR:PVRL3 trans heterodimer interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317776", "species_10314618" ], "products": [ "species_10317891" ], "modifiers": [], "additional_components": [ "ENSXETT00000020211", "ENSXETG00000038811", "A0A6I8QUW8", "ENSXETG00000038811", "F7E015", "ENSXETT00000020211" ] }, "reaction_10317782": { "compartment": "compartment_204883", "id": "reaction_10317782", "reactome": "R-XTR-419011", "name": "Transhomodimerization of Nectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317778" ], "products": [ "species_10317780" ], "modifiers": [], "additional_components": [ "F7E015", "ENSXETT00000020211", "F7E015", "ENSXETT00000020211" ] }, "reaction_10331249": { "compartment": "compartment_984", "id": "reaction_10331249", "reactome": "R-XTR-5692437", "name": "ANG binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331241", "species_10331245" ], "products": [ "species_10331247" ], "modifiers": [], "additional_components": [ "ENSXETG00000038487", "A0A6I8R6T7", "ENSXETG00000038487" ] }, "reaction_10317889": { "compartment": "compartment_204883", "id": "reaction_10317889", "reactome": "R-XTR-420592", "name": "Transhomodimerization of Nectin-like (Necl) proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317885" ], "products": [ "species_10317887" ], "modifiers": [], "additional_components": [ "Q6DJ83", "ENSXETG00000026489", "Q6DJ83", "ENSXETG00000026489" ] }, "reaction_10337532": { "compartment": "compartment_70101", "id": "reaction_10337532", "reactome": "R-XTR-9023912", "name": "AGO2 cleaves passenger strand of duplex siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325973" ], "products": [ "species_10337529" ], "modifiers": [ [ "species_10325973", "catalyst" ] ], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "Q6DJB9", "ENSXETT00000051244", "Q6DJB9", "ENSXETT00000051244" ] }, "reaction_10317966": { "compartment": "compartment_70101", "id": "reaction_10317966", "reactome": "R-XTR-426464", "name": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426463", "species_10315976" ], "products": [ "species_10317963" ], "modifiers": [ [ "species_10315976", "catalyst" ] ], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175", "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175", "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175" ] }, "reaction_10325989": { "compartment": "compartment_70101", "id": "reaction_10325989", "reactome": "R-XTR-2106625", "name": "Duplex siRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317963" ], "products": [ "species_10325979" ], "modifiers": [], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175", "B3DLA6", "ENSXETT00000096069", "Q6DJB9", "ENSXETT00000051244", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175" ] }, "reaction_10325987": { "compartment": "compartment_70101", "id": "reaction_10325987", "reactome": "R-XTR-2106615", "name": "Removal of siRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325979" ], "products": [ "species_10325985" ], "modifiers": [], "additional_components": [ "B3DLA6", "ENSXETT00000096069", "Q6DJB9", "ENSXETT00000051244", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175", "B3DLA6", "ENSXETT00000096069", "A0A6I8S266", "ENSXETG00000036175", "Q6DJB9", "ENSXETT00000051244", "Q5BJ52", "ENSXETG00000012644" ] }, "reaction_10317981": { "compartment": "compartment_70101", "id": "reaction_10317981", "reactome": "R-XTR-426520", "name": "Endonucleolytic RISC hydrolyzes target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426523" ], "products": [ "species_426511" ], "modifiers": [ [ "species_10317970", "catalyst" ] ], "additional_components": [ "Q6DJB9", "ENSXETT00000051244" ] }, "reaction_10317978": { "compartment": "compartment_70101", "id": "reaction_10317978", "reactome": "R-XTR-426489", "name": "RISC binds inexactly matching target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317970", "species_10317974", "species_426515" ], "products": [ "species_10317976" ], "modifiers": [], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "ENSXETG00000030437", "A0A6I8RHW3", "ENSXETG00000030437", "Q6DJB9", "ENSXETT00000051244" ] }, "reaction_10316176": { "compartment": "compartment_70101", "id": "reaction_10316176", "reactome": "R-XTR-210805", "name": "Removal of miRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316164" ], "products": [ "species_10316174" ], "modifiers": [], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "A0A6I8S266", "ENSXETG00000036175", "Q5BJ52", "ENSXETG00000012644", "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "Q5BJ52", "ENSXETG00000012644", "A0A6I8S266", "ENSXETG00000036175" ] }, "reaction_10325971": { "compartment": "compartment_70101", "id": "reaction_10325971", "reactome": "R-XTR-2106614", "name": "Duplex miRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10325969" ], "products": [ "species_10316164" ], "modifiers": [], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "A0A6I8S266", "ENSXETG00000036175", "Q5BJ52", "ENSXETG00000012644", "Q6DJB9", "ENSXETT00000051244", "B3DLA6", "ENSXETT00000096069", "A0A6I8S266", "ENSXETG00000036175", "Q5BJ52", "ENSXETG00000012644" ] }, "reaction_10329786": { "compartment": "compartment_70101", "id": "reaction_10329786", "reactome": "R-XTR-5578966", "name": "TNRC6A:AGO2:miRNA is transported into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329778" ], "products": [ "species_10329784" ], "modifiers": [], "additional_components": [ "Q6DJB9", "ENSXETT00000051244", "A0A6I8RHW3", "ENSXETG00000030437", "A0A6I8RHW3", "ENSXETG00000030437", "Q6DJB9", "ENSXETT00000051244" ] }, "reaction_10329780": { "compartment": "compartment_70101", "id": "reaction_10329780", "reactome": "R-XTR-5578965", "name": "TNRC6A binds AGO2:miRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317974", "species_10316168" ], "products": [ "species_10329778" ], "modifiers": [], "additional_components": [ "ENSXETG00000030437", "Q6DJB9", "ENSXETT00000051244", "Q6DJB9", "ENSXETT00000051244", "A0A6I8RHW3", "ENSXETG00000030437" ] }, "reaction_10316485": { "compartment": "compartment_7660", "id": "reaction_10316485", "reactome": "R-XTR-212252", "name": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316481", "species_10316457" ], "products": [ "species_10316483" ], "modifiers": [], "additional_components": [ "A0A6I8QJB3", "ENSXETG00000020362", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QJB3", "ENSXETG00000020362", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146" ] }, "reaction_10316517": { "compartment": "compartment_7660", "id": "reaction_10316517", "reactome": "R-XTR-212269", "name": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10316508" ], "products": [ "species_77502", "species_10316514" ], "modifiers": [ [ "species_10316508", "catalyst" ] ], "additional_components": [ "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146" ] }, "reaction_10316502": { "compartment": "compartment_7660", "id": "reaction_10316502", "reactome": "R-XTR-212263", "name": "PRC2 trimethylates histone H3 at lysine-27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10316483" ], "products": [ "species_77502", "species_10316499" ], "modifiers": [ [ "species_10316483", "catalyst" ] ], "additional_components": [ "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QJB3", "ENSXETG00000020362", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QJB3", "ENSXETG00000020362", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146", "A0A6I8QNX3", "ENSXETG00000039206", "A0A6I8SS59", "ENSXETG00000039803", "A0A6I8RKR7", "ENSXETG00000035354", "A0A6I8QJB3", "ENSXETG00000020362", "Q28DT7", "ENSXETT00000022912", "Q6P315", "ENSXETT00000002157", "Q28D84", "ENSXETG00000020146" ] }, "reaction_10329316": { "compartment": "compartment_7660", "id": "reaction_10329316", "reactome": "R-XTR-5221061", "name": "TDG excises 5-carboxylcytosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5220996", "species_10312379" ], "products": [ "species_5221064", "species_10312409" ], "modifiers": [ [ "species_10312379", "catalyst" ] ], "additional_components": [ "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927", "ENSXETG00000025927" ] }, "reaction_10329314": { "compartment": "compartment_7660", "id": "reaction_10329314", "reactome": "R-XTR-5220959", "name": "TDG excises 5-formylcytosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5221062", "species_10312379" ], "products": [ "species_5221065", "species_10312409" ], "modifiers": [ [ "species_10312379", "catalyst" ] ], "additional_components": [ "ENSXETG00000025927", "A0A6I8RWH5", "ENSXETG00000025927", "ENSXETG00000025927" ] }, "reaction_10330834": { "compartment": "compartment_70101", "id": "reaction_10330834", "reactome": "R-XTR-5686315", "name": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312336" ], "products": [ "species_10312054", "species_10312334" ], "modifiers": [], "additional_components": [ "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387", "A0A6I8RAF1", "ENSXETG00000039550", "ENSXETG00000039550", "F7DKF6", "ENSXETT00000044021", "Q66II3", "ENSXETT00000027387" ] }, "reaction_10312039": { "compartment": "compartment_876", "id": "reaction_10312039", "reactome": "R-XTR-74734", "name": "Re-integration of insulin receptor into plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312037" ], "products": [ "species_10312021" ], "modifiers": [], "additional_components": [ "A0A6I8QUB9", "ENSXETG00000013518", "A0A6I8QUB9", "ENSXETG00000013518" ] }, "reaction_10322416": { "compartment": "compartment_876", "id": "reaction_10322416", "reactome": "R-XTR-1306957", "name": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10322413", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "A0A6I8RUB1", "ENSXETG00000007252" ] }, "reaction_10322418": { "compartment": "compartment_876", "id": "reaction_10322418", "reactome": "R-XTR-1306963", "name": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313814", "species_10322318" ], "products": [ "species_10322409" ], "modifiers": [], "additional_components": [ "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "Q66II3", "ENSXETT00000027387", "C0IMZ9", "ENSXETT00000038110" ] }, "reaction_10324487": { "compartment": "compartment_876", "id": "reaction_10324487", "reactome": "R-XTR-1963563", "name": "MATK (CSK homologous kinase) binds phosphorylated ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10324483", "species_10322318" ], "products": [ "species_10324485" ], "modifiers": [], "additional_components": [ "ENSXETG00000032315", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "A0A6I8RYR6", "ENSXETG00000032315" ] }, "reaction_10335698": { "compartment": "compartment_876", "id": "reaction_10335698", "reactome": "R-XTR-8864125", "name": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335683", "species_29356" ], "products": [ "species_29372", "species_10335695" ], "modifiers": [ [ "species_10335683", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145" ] }, "reaction_10324503": { "compartment": "compartment_876", "id": "reaction_10324503", "reactome": "R-XTR-1963582", "name": "Trans-autophosphorylation of ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10324500" ], "products": [ "species_29370", "species_10322311" ], "modifiers": [ [ "species_10324500", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145" ] }, "reaction_10322327": { "compartment": "compartment_876", "id": "reaction_10322327", "reactome": "R-XTR-1250195", "name": "SHC1 phosphorylation by ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322320", "species_113592" ], "products": [ "species_29370", "species_10322324" ], "modifiers": [ [ "species_10322320", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145" ] }, "reaction_10332266": { "compartment": "compartment_70101", "id": "reaction_10332266", "reactome": "R-XTR-6785636", "name": "Phosphorylated ERBB2 heterodimers bind MEMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10332262", "species_10322318" ], "products": [ "species_10332264" ], "modifiers": [], "additional_components": [ "ENSXETT00000018710", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "Q6DJ03", "ENSXETT00000018710" ] }, "reaction_10324496": { "compartment": "compartment_876", "id": "reaction_10324496", "reactome": "R-XTR-1963581", "name": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10324493" ], "products": [ "species_29370", "species_10322316" ], "modifiers": [ [ "species_10324493", "catalyst" ] ], "additional_components": [ "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145", "F7C8B9", "ENSXETT00000006761", "F7CWY4", "ENSXETT00000011877", "A0A6I8S7Y3", "ENSXETG00000015145" ] }, "reaction_10322488": { "compartment": "compartment_70101", "id": "reaction_10322488", "reactome": "R-XTR-1433415", "name": "Activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317330", "species_29438" ], "products": [ "species_29420", "species_10312717" ], "modifiers": [ [ "species_10322485", "catalyst" ] ], "additional_components": [ "species_29420", "Q6GL60", "ENSXETT00000092508", "Q6GL60", "ENSXETT00000092508", "species_29438", "species_179838", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10312285": { "compartment": "compartment_876", "id": "reaction_10312285", "reactome": "R-XTR-83660", "name": "Membrane-anchored TNF-alpha binds TNFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312281", "species_10312271" ], "products": [ "species_10312279", "species_10312283" ], "modifiers": [], "additional_components": [ "F6X123", "ENSXETT00000023023", "A0A6I8PW21", "ENSXETG00000032118", "ENSXETT00000023023", "A0A6I8PW21", "ENSXETG00000032118" ] }, "reaction_10327781": { "compartment": "compartment_876", "id": "reaction_10327781", "reactome": "R-XTR-3371353", "name": "Soluble TNF-alpha binds TNFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327777", "species_10312281" ], "products": [ "species_10327779", "species_10312279" ], "modifiers": [], "additional_components": [ "F6X123", "ENSXETT00000023023", "A0A6I8PW21", "ENSXETG00000032118", "A0A6I8PW21", "ENSXETG00000032118", "ENSXETT00000023023" ] }, "reaction_10337807": { "compartment": "compartment_876", "id": "reaction_10337807", "reactome": "R-XTR-9624272", "name": "MMPs cleave HB-EGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337798" ], "products": [ "species_10337800", "species_10313836" ], "modifiers": [ [ "species_10337802", "catalyst" ], [ "species_10337805", "catalyst" ] ], "additional_components": [ "ENSXETG00000039798", "ENSXETG00000039798", "ENSXETG00000039798", "A0A6I8PRW9", "ENSXETG00000033700", "species_428203" ] }, "reaction_10337899": { "compartment": "compartment_7660", "id": "reaction_10337899", "reactome": "R-XTR-9632873", "name": "p-S10 CDKN1B translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337895" ], "products": [ "species_10337897" ], "modifiers": [], "additional_components": [ "ENSXETG00000038125", "ENSXETG00000038125" ] }, "reaction_10337824": { "compartment": "compartment_876", "id": "reaction_10337824", "reactome": "R-XTR-9625813", "name": "S1P binds S1PR3 in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5218688", "species_10317807" ], "products": [ "species_10337805" ], "modifiers": [], "additional_components": [ "ENSXETG00000033700", "A0A6I8PRW9", "ENSXETG00000033700", "species_428203" ] }, "reaction_10313536": { "compartment": "compartment_17957", "id": "reaction_10313536", "reactome": "R-XTR-174731", "name": "Degradation of newly synthesized ApoB-48", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313490" ], "products": [], "modifiers": [], "additional_components": [ "ENSXETG00000026768" ] }, "reaction_10335790": { "compartment": "compartment_17960", "id": "reaction_10335790", "reactome": "R-XTR-8866327", "name": "VLDL translocates from SER lumen to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335778" ], "products": [ "species_10335788" ], "modifiers": [], "additional_components": [ "species_171142", "species_171126", "species_216762", "species_163579", "A0A6I8RKY6", "ENSXETG00000026768", "species_171126", "A0A6I8RKY6", "ENSXETG00000026768", "species_163579", "species_171142", "species_216762" ] }, "reaction_10335786": { "compartment": "compartment_17960", "id": "reaction_10335786", "reactome": "R-XTR-8866308", "name": "pre-VLDL translocates from RER membrane to SER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335784" ], "products": [ "species_10335776" ], "modifiers": [], "additional_components": [ "species_171126", "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "species_171126" ] }, "reaction_10335780": { "compartment": "compartment_70101", "id": "reaction_10335780", "reactome": "R-XTR-8866304", "name": "pre-VLDL binds lipids to form VLDL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335776", "species_8866316", "species_8866305", "species_8866307", "species_8866324" ], "products": [ "species_10335778" ], "modifiers": [], "additional_components": [ "A0A6I8RKY6", "ENSXETG00000026768", "species_171142", "species_171126", "species_171142", "species_171126", "species_216762", "species_163579", "A0A6I8RKY6", "ENSXETG00000026768" ] }, "reaction_10330351": { "compartment": "compartment_70101", "id": "reaction_10330351", "reactome": "R-XTR-5661217", "name": "MT1A binds zinc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330347", "species_29426" ], "products": [ "species_10330349" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "species_29426", "A0A6I8RW79", "ENSXETG00000030675" ] }, "reaction_10330383": { "compartment": "compartment_70101", "id": "reaction_10330383", "reactome": "R-XTR-5662620", "name": "MT3 binds cadmium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1132098", "species_10330367" ], "products": [ "species_10330381" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "A0A6I8RW79", "ENSXETG00000030675", "species_1132098" ] }, "reaction_10330379": { "compartment": "compartment_70101", "id": "reaction_10330379", "reactome": "R-XTR-5662613", "name": "MT3 exchanges zinc for copper", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330369", "species_209799" ], "products": [ "species_10330377", "species_29426" ], "modifiers": [], "additional_components": [ "A0A6I8RW79", "ENSXETG00000030675", "species_29426", "A0A6I8RW79", "ENSXETG00000030675", "species_29426", "species_3299744" ] }, "reaction_10330375": { "compartment": "compartment_70101", "id": "reaction_10330375", "reactome": "R-XTR-5662608", "name": "MT2A binds cadmium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330347", "species_1132098" ], "products": [ "species_10330373" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "species_1132098", "A0A6I8RW79", "ENSXETG00000030675" ] }, "reaction_10330355": { "compartment": "compartment_70101", "id": "reaction_10330355", "reactome": "R-XTR-5661230", "name": "MT1A binds arsenic", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5661216", "species_10330347" ], "products": [ "species_10330353" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "A0A6I8RW79", "ENSXETG00000030675", "species_5661216" ] }, "reaction_10330387": { "compartment": "compartment_70101", "id": "reaction_10330387", "reactome": "R-XTR-5662986", "name": "MT2A binds copper", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330347", "species_3299744" ], "products": [ "species_10330385" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "species_3299744", "A0A6I8RW79", "ENSXETG00000030675" ] }, "reaction_10330371": { "compartment": "compartment_70101", "id": "reaction_10330371", "reactome": "R-XTR-5662606", "name": "MT3 binds zinc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426", "species_10330367" ], "products": [ "species_10330369" ], "modifiers": [], "additional_components": [ "ENSXETG00000030675", "A0A6I8RW79", "ENSXETG00000030675", "species_29426" ] }, "reaction_10330863": { "compartment": "compartment_70101", "id": "reaction_10330863", "reactome": "R-XTR-5687107", "name": "MAPK4,6 translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330857" ], "products": [ "species_10330861" ], "modifiers": [], "additional_components": [ "A0A6I8RH21", "ENSXETG00000038723", "A0A6I8RH21", "ENSXETG00000038723" ] }, "reaction_10330849": { "compartment": "compartment_70101", "id": "reaction_10330849", "reactome": "R-XTR-5687086", "name": "PAK1,2,3 phosphorylates MAPK6,4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10330843" ], "products": [ "species_29370", "species_10330846" ], "modifiers": [ [ "species_10329598", "catalyst" ] ], "additional_components": [ "ENSXETG00000038723", "ENSXETG00000038723", "ENSXETG00000011808" ] }, "reaction_10338027": { "compartment": "compartment_12045", "id": "reaction_10338027", "reactome": "R-XTR-9653514", "name": "USP17L2 deubiquitinates RCE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10338022" ], "products": [ "species_10338024", "species_10331757" ], "modifiers": [ [ "species_10331547", "catalyst" ] ], "additional_components": [ "ENSXETT00000056088", "ENSXETT00000056088", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "ENSXETT00000015033" ] }, "reaction_10338001": { "compartment": "compartment_876", "id": "reaction_10338001", "reactome": "R-XTR-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10337997" ], "products": [ "species_10337999" ], "modifiers": [], "additional_components": [ "Q6GL10", "ENSXETT00000004138", "Q6DEY3", "ENSXETT00000057305", "Q6GL10", "ENSXETT00000004138", "Q6DEY3", "ENSXETT00000057305" ] }, "reaction_10330310": { "compartment": "compartment_876", "id": "reaction_10330310", "reactome": "R-XTR-5658438", "name": "SPRED dimer binds NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330297", "species_10330301" ], "products": [ "species_10330303" ], "modifiers": [], "additional_components": [ "Q66JG9", "ENSXETT00000039156", "ENSXETG00000021350", "A0A6I8R7X8", "ENSXETG00000021350", "Q66JG9", "ENSXETT00000039156" ] }, "reaction_10337357": { "compartment": "compartment_70101", "id": "reaction_10337357", "reactome": "R-XTR-9014294", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312723", "species_10337353" ], "products": [ "species_10337355" ], "modifiers": [], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "A0A6I8SQB3", "ENSXETG00000005314", "A0A6I8S090", "ENSXETG00000032218", "A0A6I8SQB3", "ENSXETG00000005314", "A0A6I8S090", "ENSXETG00000032218", "F7DEH8", "ENSXETT00000009928", "species_29438" ] }, "reaction_10337369": { "compartment": "compartment_876", "id": "reaction_10337369", "reactome": "R-XTR-9014420", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312723" ], "products": [ "species_10330417" ], "modifiers": [], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "F7DEH8", "ENSXETT00000009928", "species_29438" ] }, "reaction_10338297": { "compartment": "compartment_876", "id": "reaction_10338297", "reactome": "R-XTR-9714483", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312723" ], "products": [ "species_10338295" ], "modifiers": [], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "F7DEH8", "ENSXETT00000009928", "species_29438" ] }, "reaction_10337367": { "compartment": "compartment_70101", "id": "reaction_10337367", "reactome": "R-XTR-9014296", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10337351" ], "products": [ "species_10312723", "species_29420" ], "modifiers": [ [ "species_10337364", "catalyst" ] ], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29420", "F7DEH8", "ENSXETT00000009928", "species_29438", "A4II46", "ENSXETT00000074782", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10338289": { "compartment": "compartment_17906", "id": "reaction_10338289", "reactome": "R-XTR-9714477", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338279", "species_10338285" ], "products": [ "species_10338287" ], "modifiers": [], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "F7DEH8", "ENSXETT00000009928", "species_29438" ] }, "reaction_10338291": { "compartment": "compartment_876", "id": "reaction_10338291", "reactome": "R-XTR-9714480", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312723" ], "products": [ "species_10338279" ], "modifiers": [], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "F7DEH8", "ENSXETT00000009928", "species_29438" ] }, "reaction_10337362": { "compartment": "compartment_70101", "id": "reaction_10337362", "reactome": "R-XTR-9014295", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312723", "species_29356" ], "products": [ "species_29372", "species_10337351" ], "modifiers": [ [ "species_10337359", "catalyst" ] ], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "species_29438", "F7DEH8", "ENSXETT00000009928", "species_29420", "A0A6I8QIL4", "ENSXETG00000001985", "B5DFQ4", "ENSXETT00000003971" ] }, "reaction_10311975": { "compartment": "compartment_876", "id": "reaction_10311975", "reactome": "R-XTR-73945", "name": "FAS-mediated dimerization of procaspase-8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311969", "species_10311967" ], "products": [ "species_10311973" ], "modifiers": [], "additional_components": [ "A0A6I8Q0P2", "ENSXETG00000032748", "A0A6I8PTW1", "ENSXETG00000031916", "A0A6I8QWZ8", "ENSXETG00000041356", "ENSXETG00000032748", "A0A6I8PTW1", "ENSXETG00000031916", "A0A6I8QWZ8", "ENSXETG00000041356", "A0A6I8Q0P2", "ENSXETG00000032748" ] }, "reaction_10338303": { "compartment": "compartment_876", "id": "reaction_10338303", "reactome": "R-XTR-9714694", "name": "RAC3 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337426" ], "products": [ "species_10338301" ], "modifiers": [], "additional_components": [ "species_29438", "species_29438" ] }, "reaction_10337431": { "compartment": "compartment_876", "id": "reaction_10337431", "reactome": "R-XTR-9018806", "name": "RAC3 GAPs stimulate RAC3 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337426", "species_29356" ], "products": [ "species_10337424", "species_29372" ], "modifiers": [ [ "species_10337428", "catalyst" ] ], "additional_components": [ "species_29438", "species_29420", "A0A6I8QIL4", "ENSXETG00000001985", "B5DFQ4", "ENSXETT00000003971" ] }, "reaction_10337441": { "compartment": "compartment_876", "id": "reaction_10337441", "reactome": "R-XTR-9018807", "name": "RAC3 GDIs block activation of RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337424", "species_10337433" ], "products": [ "species_10337439" ], "modifiers": [], "additional_components": [ "species_29420", "species_29420" ] }, "reaction_10337386": { "compartment": "compartment_70101", "id": "reaction_10337386", "reactome": "R-XTR-9018745", "name": "RHOQ GAPs stimulate RHOQ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337379", "species_29356" ], "products": [ "species_29372", "species_10337381" ], "modifiers": [ [ "species_10337383", "catalyst" ] ], "additional_components": [ "F6ZQ78", "ENSXETT00000010273", "species_29438", "F6ZQ78", "ENSXETT00000010273", "species_29420", "A0A6I8QIL4", "ENSXETG00000001985", "A0A6I8T1P4", "ENSXETG00000005630", "B5DFQ4", "ENSXETT00000003971" ] }, "reaction_10337474": { "compartment": "compartment_876", "id": "reaction_10337474", "reactome": "R-XTR-9018836", "name": "RHOQ translocates to the Golgi-associated vesicle membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337379" ], "products": [ "species_10337472" ], "modifiers": [], "additional_components": [ "F6ZQ78", "ENSXETT00000010273", "species_29438", "F6ZQ78", "ENSXETT00000010273", "species_29438" ] }, "reaction_10337263": { "compartment": "compartment_70101", "id": "reaction_10337263", "reactome": "R-XTR-9013024", "name": "RHOB binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337259", "species_10317689" ], "products": [ "species_10337261" ], "modifiers": [], "additional_components": [ "A0A6I8R6D3", "ENSXETG00000006092", "A0A6I8SJ25", "ENSXETG00000017030", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8Q6H0", "ENSXETG00000023782", "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8R6D3", "ENSXETG00000006092", "A0A6I8SJ25", "ENSXETG00000017030", "A0A6I8PK39", "ENSXETG00000039434", "A0A6I8Q6H0", "ENSXETG00000023782" ] }, "reaction_10338159": { "compartment": "compartment_74700", "id": "reaction_10338159", "reactome": "R-XTR-9690493", "name": "RHOB binds effectors on endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338155", "species_10330399" ], "products": [ "species_10338157" ], "modifiers": [], "additional_components": [ "A0A6I8R8W7", "ENSXETG00000018271", "A0A6I8RD71", "ENSXETG00000018144", "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438", "A0A6I8R8W7", "ENSXETG00000018271", "A0A6I8RD71", "ENSXETG00000018144" ] }, "reaction_10337240": { "compartment": "compartment_70101", "id": "reaction_10337240", "reactome": "R-XTR-9013022", "name": "RHOB GAPs stimulate RHOB GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10317689" ], "products": [ "species_29372", "species_10337201" ], "modifiers": [ [ "species_10337237", "catalyst" ] ], "additional_components": [ "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29420", "A0A6I8QIL4", "ENSXETG00000001985", "A4II46", "ENSXETT00000074782", "A0A6I8T1P4", "ENSXETG00000005630", "B5DFQ4", "ENSXETT00000003971" ] }, "reaction_10337243": { "compartment": "compartment_876", "id": "reaction_10337243", "reactome": "R-XTR-9013023", "name": "RHOB GEFs activate RHOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10337201" ], "products": [ "species_29420", "species_10317689" ], "modifiers": [ [ "species_10316060", "catalyst" ] ], "additional_components": [ "Q6NVL3", "ENSXETT00000056231", "species_29420", "Q6NVL3", "ENSXETT00000056231", "species_29438", "ENSXETG00000038787" ] }, "reaction_10337211": { "compartment": "compartment_70101", "id": "reaction_10337211", "reactome": "R-XTR-9013021", "name": "GDIs block activation of RHOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337201", "species_10337205" ], "products": [ "species_10337209" ], "modifiers": [], "additional_components": [ "Q6NVL3", "ENSXETT00000056231", "species_29420", "ENSXETT00000020510", "F7D6Y2", "ENSXETT00000020510", "Q6NVL3", "ENSXETT00000056231", "species_29420" ] }, "reaction_10338161": { "compartment": "compartment_876", "id": "reaction_10338161", "reactome": "R-XTR-9690494", "name": "RHOB translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317689" ], "products": [ "species_10330399" ], "modifiers": [], "additional_components": [ "Q6NVL3", "ENSXETT00000056231", "species_29438", "Q6NVL3", "ENSXETT00000056231", "species_29438" ] }, "reaction_10337468": { "compartment": "compartment_70101", "id": "reaction_10337468", "reactome": "R-XTR-9018826", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10337449" ], "products": [ "species_29372", "species_10337465" ], "modifiers": [ [ "species_10337449", "catalyst" ] ], "additional_components": [ "Q6DIS1", "ENSXETT00000007838", "species_29438", "Q6DIS1", "ENSXETT00000007838", "species_29420", "Q6DIS1", "ENSXETT00000007838", "species_29438" ] }, "reaction_10337463": { "compartment": "compartment_70101", "id": "reaction_10337463", "reactome": "R-XTR-9018824", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337459", "species_10337449" ], "products": [ "species_10337461" ], "modifiers": [], "additional_components": [ "A0A6I8RC59", "ENSXETG00000013857", "A0A6I8RIZ7", "ENSXETG00000032904", "Q6DIS1", "ENSXETT00000007838", "species_29438", "Q6DIS1", "ENSXETT00000007838", "species_29438", "A0A6I8RC59", "ENSXETG00000013857", "A0A6I8RIZ7", "ENSXETG00000032904" ] }, "reaction_10329821": { "compartment": "compartment_984", "id": "reaction_10329821", "reactome": "R-XTR-5607023", "name": "factor IXa associates with cell membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312873" ], "products": [ "species_10312962" ], "modifiers": [], "additional_components": [ "Q5M8Y0", "ENSXETT00000025939", "Q5M8Y0", "ENSXETT00000025939" ] }, "reaction_10312988": { "compartment": "compartment_984", "id": "reaction_10312988", "reactome": "R-XTR-158340", "name": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312984", "species_10312972" ], "products": [ "species_10312986" ], "modifiers": [], "additional_components": [ "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942", "A0A6I8S6I3", "ENSXETG00000005867", "A0A6I8S6I3", "ENSXETG00000005867", "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942" ] }, "reaction_10329823": { "compartment": "compartment_984", "id": "reaction_10329823", "reactome": "R-XTR-5607043", "name": "factor VIIIa associates with cell membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312938" ], "products": [ "species_10312956" ], "modifiers": [], "additional_components": [ "A0A6I8SC83", "ENSXETG00000038196", "A0A6I8SC83", "ENSXETG00000038196" ] }, "reaction_10338059": { "compartment": "compartment_17957", "id": "reaction_10338059", "reactome": "R-XTR-9670673", "name": "FIX is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10338057" ], "products": [ "species_10312867" ], "modifiers": [], "additional_components": [ "ENSXETT00000025939", "ENSXETT00000025939" ] }, "reaction_10338055": { "compartment": "compartment_984", "id": "reaction_10338055", "reactome": "R-XTR-9670014", "name": "Factor VIIIa dissociates ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312938" ], "products": [ "species_10312934", "species_10338053" ], "modifiers": [], "additional_components": [ "A0A6I8SC83", "ENSXETG00000038196", "ENSXETG00000038196", "A0A6I8SC83", "ENSXETG00000038196" ] }, "reaction_10312966": { "compartment": "compartment_984", "id": "reaction_10312966", "reactome": "R-XTR-158278", "name": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312962", "species_10312956" ], "products": [ "species_10312964" ], "modifiers": [ [ "species_74112", "catalyst" ] ], "additional_components": [ "Q5M8Y0", "ENSXETT00000025939", "A0A6I8SC83", "ENSXETG00000038196", "A0A6I8SC83", "ENSXETG00000038196", "Q5M8Y0", "ENSXETT00000025939" ] }, "reaction_10338033": { "compartment": "compartment_17957", "id": "reaction_10338033", "reactome": "R-XTR-9661625", "name": "FVIII is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331360" ], "products": [ "species_10312922" ], "modifiers": [], "additional_components": [ "ENSXETG00000038196", "A0A6I8SC83", "ENSXETG00000038196" ] }, "reaction_10312930": { "compartment": "compartment_984", "id": "reaction_10312930", "reactome": "R-XTR-158118", "name": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312922", "species_10312926" ], "products": [ "species_10312928" ], "modifiers": [], "additional_components": [ "A0A6I8SC83", "ENSXETG00000038196", "F6TMK5", "ENSXETT00000046700", "F6TMK5", "ENSXETT00000046700", "A0A6I8SC83", "ENSXETG00000038196" ] }, "reaction_10330109": { "compartment": "compartment_5263228", "id": "reaction_10330109", "reactome": "R-XTR-5635843", "name": "GLI translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330107" ], "products": [ "species_10330101" ], "modifiers": [], "additional_components": [ "ENSXETG00000036606", "ENSXETG00000036606" ] }, "reaction_10330074": { "compartment": "compartment_261122", "id": "reaction_10330074", "reactome": "R-XTR-5632677", "name": "PTCH is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330070" ], "products": [ "species_10330072" ], "modifiers": [], "additional_components": [ "ENSXETG00000014834", "ENSXETG00000014834" ] }, "reaction_10330132": { "compartment": "compartment_7660", "id": "reaction_10330132", "reactome": "R-XTR-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330129", "species_10327687" ], "products": [ "species_10330125" ], "modifiers": [ [ "species_10330129", "catalyst" ] ], "additional_components": [ "A4IHP4", "ENSXETT00000017945", "Q6P8B3", "ENSXETT00000057841", "A0A6I8S0I4", "ENSXETG00000035313", "A0A6I8PW00", "ENSXETG00000036372", "A0A6I8RD22", "ENSXETG00000037858", "A4IHP4", "ENSXETT00000017945", "Q6P8B3", "ENSXETT00000057841", "A0A6I8S0I4", "ENSXETG00000035313", "A4IHP4", "ENSXETT00000017945", "Q6P8B3", "ENSXETT00000057841", "A0A6I8S0I4", "ENSXETG00000035313" ] }, "reaction_10330098": { "compartment": "compartment_261122", "id": "reaction_10330098", "reactome": "R-XTR-5635102", "name": "GPR161 is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329842" ], "products": [ "species_10330096" ], "modifiers": [], "additional_components": [ "ENSXETG00000002410", "ENSXETG00000002410" ] }, "reaction_10329881": { "compartment": "compartment_20699", "id": "reaction_10329881", "reactome": "R-XTR-5617828", "name": "TRIP11:IFT20 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329879" ], "products": [ "species_10329873", "species_10329877" ], "modifiers": [], "additional_components": [ "A0A6I8SZZ2", "ENSXETG00000015833", "Q66KL7", "ENSXETT00000069320", "ENSXETT00000069320", "ENSXETG00000015833" ] }, "reaction_10321867": { "compartment": "compartment_70101", "id": "reaction_10321867", "reactome": "R-XTR-1183128", "name": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1183111" ], "products": [ "species_29382", "species_1183191" ], "modifiers": [ [ "species_10321864", "catalyst" ] ], "additional_components": [ "species_74112", "F6YPC2", "ENSXETT00000038130" ] }, "reaction_10328860": { "compartment": "compartment_7660", "id": "reaction_10328860", "reactome": "R-XTR-4722133", "name": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328853", "species_113671", "species_113685" ], "products": [ "species_29478", "species_10327320", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328857", "catalyst" ] ], "additional_components": [ "ENSXETT00000070583" ] }, "reaction_10327327": { "compartment": "compartment_7660", "id": "reaction_10327327", "reactome": "R-XTR-3214912", "name": "KDM1A, KDM1B demethylate MeK5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10327318" ], "products": [ "species_29478", "species_10327320" ], "modifiers": [ [ "species_10327324", "catalyst" ] ], "additional_components": [ "ENSXETG00000015429" ] }, "reaction_10328879": { "compartment": "compartment_7660", "id": "reaction_10328879", "reactome": "R-XTR-4724284", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328864", "species_113671", "species_113685" ], "products": [ "species_29478", "species_10327320", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328876", "catalyst" ] ], "additional_components": [ "Q08D35", "ENSXETG00000002669", "A0A6I8Q587", "ENSXETG00000006700" ] }, "reaction_10330334": { "compartment": "compartment_7660", "id": "reaction_10330334", "reactome": "R-XTR-5661121", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10330190" ], "products": [ "species_10328898", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328914", "catalyst" ] ], "additional_components": [ "A0A6I8S4K7", "ENSXETG00000004822", "Q08D35", "ENSXETG00000002669" ] }, "reaction_10328890": { "compartment": "compartment_7660", "id": "reaction_10328890", "reactome": "R-XTR-4754181", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328881", "species_113671", "species_113685" ], "products": [ "species_10327318", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328885", "catalyst" ] ], "additional_components": [ "ENSXETT00000007540" ] }, "reaction_10328917": { "compartment": "compartment_7660", "id": "reaction_10328917", "reactome": "R-XTR-4754187", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328898", "species_113671", "species_113685" ], "products": [ "species_10328906", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328914", "catalyst" ] ], "additional_components": [ "A0A6I8S4K7", "ENSXETG00000004822", "Q08D35", "ENSXETG00000002669" ] }, "reaction_10330324": { "compartment": "compartment_7660", "id": "reaction_10330324", "reactome": "R-XTR-5661116", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329431", "species_113671", "species_113685" ], "products": [ "species_10328881", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328885", "catalyst" ] ], "additional_components": [ "ENSXETT00000007540" ] }, "reaction_10330320": { "compartment": "compartment_7660", "id": "reaction_10330320", "reactome": "R-XTR-5661114", "name": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10330145", "species_113671", "species_113685" ], "products": [ "species_10328853", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328857", "catalyst" ] ], "additional_components": [ "ENSXETT00000070583" ] }, "reaction_10330338": { "compartment": "compartment_7660", "id": "reaction_10330338", "reactome": "R-XTR-5661123", "name": "KDM1A, KDM1B demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328881" ], "products": [ "species_10327318", "species_29478" ], "modifiers": [ [ "species_10327324", "catalyst" ] ], "additional_components": [ "ENSXETG00000015429" ] }, "reaction_10330322": { "compartment": "compartment_7660", "id": "reaction_10330322", "reactome": "R-XTR-5661115", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10328862" ], "products": [ "species_10328864", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10328876", "catalyst" ] ], "additional_components": [ "Q08D35", "ENSXETG00000002669", "A0A6I8Q587", "ENSXETG00000006700" ] }, "reaction_10327428": { "compartment": "compartment_7660", "id": "reaction_10327428", "reactome": "R-XTR-3247569", "name": "PADI4 deiminates Histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10327386" ], "products": [ "species_76230", "species_10327417" ], "modifiers": [ [ "species_10327419", "catalyst" ] ], "additional_components": [ "ENSXETT00000038130" ] }, "reaction_10329663": { "compartment": "compartment_7660", "id": "reaction_10329663", "reactome": "R-XTR-5423038", "name": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313794", "species_77087" ], "products": [ "species_77502", "species_10326319" ], "modifiers": [ [ "species_10326655", "catalyst" ] ], "additional_components": [ "ENSXETG00000035354", "ENSXETG00000035354", "ENSXETT00000012803" ] }, "reaction_10330137": { "compartment": "compartment_7660", "id": "reaction_10330137", "reactome": "R-XTR-5637686", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10327318" ], "products": [ "species_77502", "species_10328881" ], "modifiers": [ [ "species_10330134", "catalyst" ] ], "additional_components": [ "B7ZUF3", "ENSXETT00000065894", "A0A6I8S8Z5", "ENSXETG00000040375" ] }, "reaction_10335723": { "compartment": "compartment_7660", "id": "reaction_10335723", "reactome": "R-XTR-8865237", "name": "SETD6 methylates RELA in the NFkB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10313349" ], "products": [ "species_77502", "species_10335716" ], "modifiers": [ [ "species_10335720", "catalyst" ] ], "additional_components": [ "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "A0A6I8SZP6", "ENSXETG00000021325", "A0A6I8PS73", "ENSXETG00000026173", "ENSXETG00000013793" ] }, "reaction_10329450": { "compartment": "compartment_7660", "id": "reaction_10329450", "reactome": "R-XTR-5244692", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10328881" ], "products": [ "species_77502", "species_10329431" ], "modifiers": [ [ "species_10329447", "catalyst" ], [ "species_10329122", "inhibitor" ] ], "additional_components": [ "A0A6I8S8Z5", "ENSXETG00000040375", "A0A6I8RD53", "ENSXETG00000039708", "A0A6I8SUP9", "ENSXETG00000037286" ] }, "reaction_10328986": { "compartment": "compartment_7660", "id": "reaction_10328986", "reactome": "R-XTR-4827382", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10328862" ], "products": [ "species_77502", "species_10328969" ], "modifiers": [ [ "species_10328983", "catalyst" ] ], "additional_components": [ "Q28CQ7", "ENSXETG00000005401", "A4IGY9", "ENSXETG00000015666", "Q08D57", "ENSXETG00000003760" ] }, "reaction_10328999": { "compartment": "compartment_7660", "id": "reaction_10328999", "reactome": "R-XTR-5159245", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10327320" ], "products": [ "species_77502", "species_10327318" ], "modifiers": [ [ "species_10328996", "catalyst" ] ], "additional_components": [ "B7ZUF3", "ENSXETT00000065894", "Q4QQN5", "ENSXETT00000036910" ] }, "reaction_10314063": { "compartment": "compartment_876", "id": "reaction_10314063", "reactome": "R-XTR-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10314060", "catalyst" ] ], "additional_components": [ "ENSXETT00000048392" ] }, "reaction_10336095": { "compartment": "compartment_876", "id": "reaction_10336095", "reactome": "R-XTR-8932955", "name": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189227", "species_74113" ], "products": [ "species_83910", "species_189254" ], "modifiers": [ [ "species_10336092", "catalyst" ] ], "additional_components": [ "species_188995", "species_70113", "species_70113", "species_188995", "ENSXETG00000036486" ] }, "reaction_10317056": { "compartment": "compartment_876", "id": "reaction_10317056", "reactome": "R-XTR-376122", "name": "DSCAM/DSCAML1 homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10317052" ], "products": [ "species_10317054" ], "modifiers": [], "additional_components": [ "ENSXETG00000003741", "A0A6I8S5X4", "ENSXETG00000003741" ] }, "reaction_10322283": { "compartment": "compartment_70101", "id": "reaction_10322283", "reactome": "R-XTR-1237325", "name": "Hemoglobin A is protonated and carbamated causing release of oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113528", "species_10322261" ], "products": [ "species_29368", "species_10322281" ], "modifiers": [], "additional_components": [ "species_189444", "P07428", "ENSXETT00000002494", "species_113533", "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566", "species_189444", "P07428", "ENSXETT00000002494", "P07429", "ENSXETT00000054566", "P08423", "ENSXETG00000024627" ] }, "reaction_10334487": { "compartment": "compartment_70101", "id": "reaction_10334487", "reactome": "R-XTR-6806831", "name": "CYB5Rs reduce MetHb to HbA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334462", "species_73473" ], "products": [ "species_70106", "species_10334468", "species_29360" ], "modifiers": [ [ "species_10334484", "catalyst" ] ], "additional_components": [ "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566", "species_917955", "P07428", "ENSXETT00000002494", "species_189444", "P07428", "ENSXETT00000002494", "P08423", "ENSXETG00000024627", "P07429", "ENSXETT00000054566", "Q5BJ68", "ENSXETT00000096157", "A0A6I8SMQ8", "ENSXETG00000035257", "Q28CZ9", "ENSXETG00000022592" ] }, "reaction_10322214": { "compartment": "compartment_984", "id": "reaction_10322214", "reactome": "R-XTR-1237047", "name": "CA4:Zn2+ hydrates CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10322211", "catalyst" ] ], "additional_components": [ "species_29426", "A0A6I8QID1", "ENSXETG00000034545" ] }, "reaction_10335965": { "compartment": "compartment_171907", "id": "reaction_10335965", "reactome": "R-XTR-8876366", "name": "LDL translocates from endosome lumen to lysosome lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10335963" ], "products": [ "species_10335734" ], "modifiers": [], "additional_components": [ "species_163579", "A0A6I8RKY6", "ENSXETG00000026768", "species_216762", "species_171126", "species_171142", "species_171126", "species_171142", "species_163579", "species_216762", "A0A6I8RKY6", "ENSXETG00000026768" ] }, "reaction_10335741": { "compartment": "compartment_161320", "id": "reaction_10335741", "reactome": "R-XTR-8865667", "name": "LIPA hydrolyses sterol esters to sterols and fatty acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_10335734" ], "products": [ "species_8848047", "species_10335736", "species_8865666" ], "modifiers": [ [ "species_10335738", "catalyst" ] ], "additional_components": [ "species_171126", "species_171142", "species_163579", "species_216762", "A0A6I8RKY6", "ENSXETG00000026768", "species_171126", "species_171142", "species_216762", "A0A6I8RKY6", "ENSXETG00000026768", "ENSXETT00000020371" ] }, "reaction_10334653": { "compartment": "compartment_70101", "id": "reaction_10334653", "reactome": "R-XTR-6813720", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10334650", "catalyst" ] ], "additional_components": [ "ENSXETG00000038694" ] }, "reaction_10335991": { "compartment": "compartment_12045", "id": "reaction_10335991", "reactome": "R-XTR-8876696", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384", "species_1500578" ], "products": [ "species_8876704", "species_76194" ], "modifiers": [ [ "species_10335988", "catalyst" ] ], "additional_components": [ "ENSXETG00000034253" ] }, "reaction_10335379": { "compartment": "compartment_876", "id": "reaction_10335379", "reactome": "R-XTR-8858252", "name": "HDLBP binds HDL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316656", "species_10335375" ], "products": [ "species_10335377" ], "modifiers": [], "additional_components": [ "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "species_171142", "species_216762", "ENSXETG00000012164", "A0A6I8S7E7", "ENSXETG00000012164", "A0A6I8PU04", "ENSXETG00000033423", "species_171126", "species_163579", "species_171142", "species_216762" ] }, "reaction_10317284": { "compartment": "compartment_17947", "id": "reaction_10317284", "reactome": "R-XTR-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_382577" ], "products": [ "species_382571", "species_29372", "species_29370" ], "modifiers": [ [ "species_10317281", "catalyst" ] ], "additional_components": [ "A0A6I8Q353", "ENSXETG00000007705" ] }, "reaction_10322479": { "compartment": "compartment_17906", "id": "reaction_10322479", "reactome": "R-XTR-1369065", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1369066", "species_29356", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1369027" ], "modifiers": [ [ "species_10322476", "catalyst" ] ], "additional_components": [ "Q08D64", "ENSXETT00000030397" ] }, "reaction_10318119": { "compartment": "compartment_876", "id": "reaction_10318119", "reactome": "R-XTR-429094", "name": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10318116", "catalyst" ] ], "additional_components": [ "ENSXETT00000007515" ] }, "reaction_10335959": { "compartment": "compartment_70101", "id": "reaction_10335959", "reactome": "R-XTR-8876319", "name": "SLC50A1 transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10335956", "catalyst" ] ], "additional_components": [ "ENSXETG00000019427" ] }, "reaction_10318099": { "compartment": "compartment_876", "id": "reaction_10318099", "reactome": "R-XTR-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10318096", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_70113", "species_29532", "ENSXETT00000048392" ] }, "reaction_10318281": { "compartment": "compartment_876", "id": "reaction_10318281", "reactome": "R-XTR-442368", "name": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71067" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10318278", "catalyst" ] ], "additional_components": [ "A0A6I8SBF5", "ENSXETG00000041263", "CHEBI:28694", "F7EFD4", "ENSXETT00000006578" ] }, "reaction_10318333": { "compartment": "compartment_876", "id": "reaction_10318333", "reactome": "R-XTR-444160", "name": "VMAT1/2 can mediate the transport of biogenic amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444154" ], "products": [ "species_444152" ], "modifiers": [ [ "species_10318330", "catalyst" ] ], "additional_components": [ "species_351601", "CHEBI:28918", "species_114523", "species_390899", "CHEBI:18357", "CHEBI:18357", "CHEBI:28918", "species_390899", "species_351601", "species_114523", "F6YMA0", "ENSXETT00000019549", "A0A6I8R508", "ENSXETG00000038313" ] }, "reaction_10318203": { "compartment": "compartment_876", "id": "reaction_10318203", "reactome": "R-XTR-434650", "name": "MATEs mediate extrusion of xenobiotics", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_446589" ], "products": [ "species_70106", "species_446597" ], "modifiers": [ [ "species_10318200", "catalyst" ] ], "additional_components": [ "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:6801", "CHEBI:16737", "CHEBI:8428", "CHEBI:42820", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "CHEBI:6801", "A4IIS8", "ENSXETG00000022931", "A0A6I8STL3", "ENSXETG00000039254" ] }, "reaction_10319068": { "compartment": "compartment_876", "id": "reaction_10319068", "reactome": "R-XTR-561253", "name": "SLC22A12 exchanges extracellular urate for cytosolic LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_429056" ], "products": [ "species_373863", "species_30034" ], "modifiers": [ [ "species_10319065", "catalyst" ] ], "additional_components": [ "ENSXETG00000023239" ] }, "reaction_10319063": { "compartment": "compartment_876", "id": "reaction_10319063", "reactome": "R-XTR-561059", "name": "OAT2 and OAT4 mediate transport of sulphate conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561071" ], "products": [ "species_561062", "species_561075" ], "modifiers": [ [ "species_10319060", "catalyst" ] ], "additional_components": [ "species_176496", "species_176501", "species_176501", "species_176496", "ENSXETG00000023239" ] }, "reaction_10319058": { "compartment": "compartment_876", "id": "reaction_10319058", "reactome": "R-XTR-561041", "name": "OAT1-3 transport organic anions with antiport of dicarboxylic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561049" ], "products": [ "species_561078", "species_561075" ], "modifiers": [ [ "species_10319055", "catalyst" ] ], "additional_components": [ "CHEBI:104011", "CHEBI:2453", "CHEBI:2453", "CHEBI:104011", "A0A6I8QMN4", "ENSXETG00000035704", "A0A6I8RMY7", "ENSXETG00000023239" ] }, "reaction_10318169": { "compartment": "compartment_876", "id": "reaction_10318169", "reactome": "R-XTR-433099", "name": "NaS2 co-transports sulphate and two sodium ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_83910", "species_174375" ], "modifiers": [ [ "species_10318166", "catalyst" ] ], "additional_components": [ "ENSXETG00000010608" ] }, "reaction_10320605": { "compartment": "compartment_947586", "id": "reaction_10320605", "reactome": "R-XTR-917839", "name": "apo-Transferrin dissociates from the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320599" ], "products": [ "species_10318912", "species_10320572" ], "modifiers": [], "additional_components": [ "A0A6I8QZE2", "ENSXETG00000040690", "Q501K5", "ENSXETG00000011814", "ENSXETG00000011814", "A0A6I8QZE2", "ENSXETG00000040690" ] }, "reaction_10320588": { "compartment": "compartment_876", "id": "reaction_10320588", "reactome": "R-XTR-917807", "name": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320576" ], "products": [ "species_10320586" ], "modifiers": [], "additional_components": [ "A0A6I8QZE2", "ENSXETG00000040690", "species_912516", "Q501K5", "ENSXETG00000011814", "species_912516", "Q501K5", "ENSXETG00000011814", "A0A6I8QZE2", "ENSXETG00000040690" ] }, "reaction_10320601": { "compartment": "compartment_70101", "id": "reaction_10320601", "reactome": "R-XTR-917814", "name": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320597" ], "products": [ "species_10320599" ], "modifiers": [], "additional_components": [ "A0A6I8QZE2", "ENSXETG00000040690", "Q501K5", "ENSXETG00000011814", "A0A6I8QZE2", "ENSXETG00000040690", "Q501K5", "ENSXETG00000011814" ] }, "reaction_10320603": { "compartment": "compartment_171907", "id": "reaction_10320603", "reactome": "R-XTR-917835", "name": "Fe3+ dissociates from holoTF:TFRC dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320586" ], "products": [ "species_10320597", "species_917966" ], "modifiers": [], "additional_components": [ "species_912516", "Q501K5", "ENSXETG00000011814", "A0A6I8QZE2", "ENSXETG00000040690", "A0A6I8QZE2", "ENSXETG00000040690", "Q501K5", "ENSXETG00000011814" ] }, "reaction_10320612": { "compartment": "compartment_984", "id": "reaction_10320612", "reactome": "R-XTR-917987", "name": "TFRC dimer binds 2xholoTF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10320574", "species_10320572" ], "products": [ "species_10320576" ], "modifiers": [], "additional_components": [ "species_912516", "Q501K5", "ENSXETG00000011814", "A0A6I8QZE2", "ENSXETG00000040690", "A0A6I8QZE2", "ENSXETG00000040690", "species_912516", "Q501K5", "ENSXETG00000011814" ] }, "reaction_10331142": { "compartment": "compartment_876", "id": "reaction_10331142", "reactome": "R-XTR-5691154", "name": "HFE binds TFRC dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331138", "species_10320572" ], "products": [ "species_10331140" ], "modifiers": [], "additional_components": [ "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8PKL5", "ENSXETG00000033834", "A0A6I8QZE2", "ENSXETG00000040690", "A0A6I8QZE2", "ENSXETG00000040690", "A0A6I8R2K0", "ENSXETG00000034817", "A0A6I8RP42", "ENSXETG00000039951", "A0A6I8Q4X5", "ENSXETG00000034817", "A0A6I8R1D6", "ENSXETG00000035146", "A0A6I8PWE5", "ENSXETG00000033504", "A0A6I8Q2E4", "ENSXETG00000032895", "A0A6I8RZT1", "ENSXETG00000017938", "A0A6I8PKL5", "ENSXETG00000033834" ] }, "reaction_10320595": { "compartment": "compartment_171907", "id": "reaction_10320595", "reactome": "R-XTR-917811", "name": "STEAP3-like proteins reduce Fe3+ to Fe2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917882", "species_917966" ], "products": [ "species_917810" ], "modifiers": [ [ "species_10320592", "catalyst" ] ], "additional_components": [ "ENSXETT00000016208" ] }, "reaction_10331101": { "compartment": "compartment_70101", "id": "reaction_10331101", "reactome": "R-XTR-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690881", "species_10331097" ], "products": [ "species_10331099" ], "modifiers": [], "additional_components": [ "ENSXETG00000009184", "A0A6I8SX09", "ENSXETG00000009184" ] }, "reaction_10331117": { "compartment": "compartment_5460", "id": "reaction_10331117", "reactome": "R-XTR-5691107", "name": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113531", "species_113529" ], "products": [ "species_5691135" ], "modifiers": [ [ "species_10331114", "catalyst" ] ], "additional_components": [ "F6T7W4", "ENSXETT00000045926" ] }, "reaction_10320607": { "compartment": "compartment_984", "id": "reaction_10320607", "reactome": "R-XTR-917888", "name": "apoTF binds 2Fe3+ to form holoTF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318912", "species_912516" ], "products": [ "species_10320574" ], "modifiers": [], "additional_components": [ "ENSXETG00000011814", "species_912516", "Q501K5", "ENSXETG00000011814" ] }, "reaction_10320566": { "compartment": "compartment_984", "id": "reaction_10320566", "reactome": "R-XTR-917805", "name": "CYBRD1:Heme reduces Fe3+ to Fe2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917828", "species_912516" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10320563", "catalyst" ] ], "additional_components": [ "species_189444", "Q5CZL8", "ENSXETT00000040828" ] }, "reaction_10331110": { "compartment": "compartment_70101", "id": "reaction_10331110", "reactome": "R-XTR-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10331099", "catalyst" ] ], "additional_components": [ "A0A6I8SX09", "ENSXETG00000009184" ] }, "reaction_10320610": { "compartment": "compartment_947586", "id": "reaction_10320610", "reactome": "R-XTR-917933", "name": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347", "species_352327" ], "products": [ "species_109276", "species_912516" ], "modifiers": [ [ "species_10318278", "catalyst" ] ], "additional_components": [ "A0A6I8SBF5", "ENSXETG00000041263", "CHEBI:28694", "F7EFD4", "ENSXETT00000006578" ] }, "reaction_10323458": { "compartment": "compartment_70101", "id": "reaction_10323458", "reactome": "R-XTR-1562626", "name": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71067", "species_29368" ], "products": [ "species_5691103" ], "modifiers": [ [ "species_10323455", "catalyst" ] ], "additional_components": [ "F6T7W4", "ENSXETT00000045926" ] }, "reaction_10320671": { "compartment": "compartment_876", "id": "reaction_10320671", "reactome": "R-XTR-936897", "name": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_29356", "species_113592", "species_83910" ], "products": [ "species_29372", "species_29804", "species_29370", "species_74113" ], "modifiers": [ [ "species_10320666", "catalyst" ], [ "species_10320669", "inhibitor" ] ], "additional_components": [ "Q6P617", "ENSXETT00000095333", "A0A6I8QKL0", "ENSXETG00000020366", "A0A6I8S802", "ENSXETG00000038243", "Q6P617", "ENSXETT00000095333", "A0A6I8QKL0", "ENSXETG00000020366", "A0A6I8S802", "ENSXETG00000038243" ] }, "reaction_10338110": { "compartment": "compartment_984", "id": "reaction_10338110", "reactome": "R-XTR-9684068", "name": "ATP1A:ATP1B:FXYD binds cardiac glycosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9684063", "species_10320666" ], "products": [ "species_10320669" ], "modifiers": [], "additional_components": [ "Q6P617", "ENSXETT00000095333", "A0A6I8QKL0", "ENSXETG00000020366", "A0A6I8S802", "ENSXETG00000038243", "Q6P617", "ENSXETT00000095333", "A0A6I8QKL0", "ENSXETG00000020366", "A0A6I8S802", "ENSXETG00000038243" ] }, "reaction_10329512": { "compartment": "compartment_70101", "id": "reaction_10329512", "reactome": "R-XTR-5251989", "name": "ATP13A4,5 transport divalent ions from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5252122", "species_113592" ], "products": [ "species_29372", "species_29370", "species_5252016" ], "modifiers": [ [ "species_10329509", "catalyst" ] ], "additional_components": [ "F7C820", "ENSXETT00000003028", "A0A6I8R4Z6", "ENSXETG00000034939" ] }, "reaction_10320699": { "compartment": "compartment_876", "id": "reaction_10320699", "reactome": "R-XTR-939763", "name": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_947594" ], "products": [ "species_29372", "species_29370", "species_947588" ], "modifiers": [ [ "species_10320696", "catalyst" ] ], "additional_components": [ "species_8959490", "species_33625", "species_33625", "species_8959490", "Q5BL50", "ENSXETG00000020878" ] }, "reaction_10318054": { "compartment": "compartment_12045", "id": "reaction_10318054", "reactome": "R-XTR-427910", "name": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_74016" ], "products": [ "species_70106", "species_111875" ], "modifiers": [ [ "species_10318040", "catalyst" ], [ "species_10318052", "catalyst" ], [ "species_10318047", "inhibitor" ] ], "additional_components": [ "A0A6I8RIR9", "ENSXETG00000009695", "A0A6I8Q1N1", "ENSXETG00000002512", "A0A6I8ST89", "ENSXETG00000036412", "A0A6I8ST89", "ENSXETG00000036412" ] }, "reaction_10329566": { "compartment": "compartment_70101", "id": "reaction_10329566", "reactome": "R-XTR-5336466", "name": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29926" ], "products": [ "species_109496" ], "modifiers": [ [ "species_10329563", "catalyst" ] ], "additional_components": [ "ENSXETG00000021985" ] }, "reaction_10337028": { "compartment": "compartment_70101", "id": "reaction_10337028", "reactome": "R-XTR-8981621", "name": "Neuroglobin:oxygen dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337024" ], "products": [ "species_29368", "species_10337022" ], "modifiers": [], "additional_components": [ "species_189444", "Q575T7", "ENSXETT00000083304", "species_113533", "species_189444", "Q575T7", "ENSXETT00000083304" ] }, "reaction_10337063": { "compartment": "compartment_70101", "id": "reaction_10337063", "reactome": "R-XTR-8982617", "name": "CYGB:O2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329583" ], "products": [ "species_29368", "species_10329581" ], "modifiers": [], "additional_components": [ "species_189444", "Q6DEW1", "ENSXETT00000093870", "species_113533", "species_189444", "Q6DEW1", "ENSXETT00000093870" ] }, "reaction_10337026": { "compartment": "compartment_70101", "id": "reaction_10337026", "reactome": "R-XTR-8981610", "name": "Neuroglobin binds oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_10337022" ], "products": [ "species_10337024" ], "modifiers": [], "additional_components": [ "species_189444", "Q575T7", "ENSXETT00000083304", "species_189444", "Q575T7", "ENSXETT00000083304", "species_113533" ] }, "reaction_10329738": { "compartment": "compartment_70101", "id": "reaction_10329738", "reactome": "R-XTR-5577050", "name": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10329735", "catalyst" ] ], "additional_components": [ "A0A6I8SN44", "ENSXETG00000041349", "A0A6I8Q2V9", "ENSXETG00000032386", "A0A6I8SMY0", "ENSXETG00000003440", "A0A6I8Q0D6", "ENSXETG00000034068" ] }, "reaction_10329869": { "compartment": "compartment_70101", "id": "reaction_10329869", "reactome": "R-XTR-5615668", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10314206", "catalyst" ] ], "additional_components": [ "A0A6I8R8Y6", "ENSXETG00000040684", "A0A6I8SP23", "ENSXETG00000041302", "A0A6I8RTD2", "ENSXETG00000038578" ] }, "reaction_10329660": { "compartment": "compartment_70101", "id": "reaction_10329660", "reactome": "R-XTR-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10329657", "catalyst" ] ], "additional_components": [ "A0A6I8RYK1", "ENSXETG00000032351", "species_29426", "F6YU63", "ENSXETT00000024409", "F7DZV1", "ENSXETT00000020485", "A0A6I8PVR9", "ENSXETG00000032433" ] }, "reaction_10329646": { "compartment": "compartment_70101", "id": "reaction_10329646", "reactome": "R-XTR-5362518", "name": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10329643", "catalyst" ] ], "additional_components": [ "A0A6I8PYC1", "ENSXETG00000033315", "Q5XGF7", "ENSXETT00000025854", "A8WGW3", "ENSXETT00000002941", "F6Z4N6", "ENSXETT00000035399" ] }, "reaction_10329909": { "compartment": "compartment_70101", "id": "reaction_10329909", "reactome": "R-XTR-5622134", "name": "CRABP1 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10329651", "species_5334816" ], "products": [ "species_10329653" ], "modifiers": [], "additional_components": [ "ENSXETG00000040354", "species_215573", "A0A6I8QHI5", "ENSXETG00000040354" ] }, "reaction_10329655": { "compartment": "compartment_70101", "id": "reaction_10329655", "reactome": "R-XTR-5362525", "name": "CYP26A1,B1,C1 4-hydroxylate atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_10329653", "species_29364" ], "products": [ "species_10329651", "species_29356", "species_5362521", "species_29366" ], "modifiers": [ [ "species_10316440", "catalyst" ] ], "additional_components": [ "species_215573", "A0A6I8QHI5", "ENSXETG00000040354", "ENSXETG00000040354", "ENSXETG00000021546" ] }, "reaction_10332441": { "compartment": "compartment_876", "id": "reaction_10332441", "reactome": "R-XTR-6794346", "name": "NRXNs bind NLGNs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10332437", "species_10332431" ], "products": [ "species_10332439" ], "modifiers": [], "additional_components": [ "A0A6I8S9J2", "ENSXETG00000035941", "ENSXETG00000011090", "A0A6I8Q952", "ENSXETG00000011090", "A0A6I8S9J2", "ENSXETG00000035941" ] }, "reaction_10332482": { "compartment": "compartment_876", "id": "reaction_10332482", "reactome": "R-XTR-6797974", "name": "LRRTMs bind NRXNs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10332478", "species_10332431" ], "products": [ "species_10332480" ], "modifiers": [], "additional_components": [ "ENSXETG00000011090", "A0A6I8Q952", "ENSXETG00000011090" ] }, "reaction_10313806": { "compartment": "compartment_17963", "id": "reaction_10313806", "reactome": "R-XTR-177107", "name": "Secretion and activation of the latent large complex of TGF-beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313438" ], "products": [ "species_10313444" ], "modifiers": [], "additional_components": [ "F6SX40", "ENSXETT00000046545", "F6SX40", "ENSXETT00000046545" ] }, "reaction_10313440": { "compartment": "compartment_20699", "id": "reaction_10313440", "reactome": "R-XTR-170844", "name": "Latent TGF-beta-1 is cleaved by furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10313434" ], "products": [ "species_10313438" ], "modifiers": [ [ "species_10313057", "catalyst" ] ], "additional_components": [ "F6SX40", "ENSXETT00000046545", "F6SX40", "ENSXETT00000046545", "ENSXETG00000015462" ] }, "reaction_10334815": { "compartment": "compartment_984", "id": "reaction_10334815", "reactome": "R-XTR-8849857", "name": "KLK5 cleaves and activates CELA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10334808" ], "products": [ "species_10334810", "species_10334812" ], "modifiers": [ [ "species_10334804", "catalyst" ] ], "additional_components": [ "ENSXETT00000031018", "ENSXETT00000031018", "ENSXETT00000031018", "ENSXETT00000037000" ] }, "reaction_10334837": { "compartment": "compartment_984", "id": "reaction_10334837", "reactome": "R-XTR-8850831", "name": "KLK5 cleaves and activates KLK8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10334831" ], "products": [ "species_10334835", "species_10334833" ], "modifiers": [ [ "species_10334804", "catalyst" ] ], "additional_components": [ "ENSXETT00000037000", "ENSXETT00000037000", "ENSXETT00000037000", "ENSXETT00000037000" ] }, "reaction_10332400": { "compartment": "compartment_984", "id": "reaction_10332400", "reactome": "R-XTR-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174675", "species_6789319" ], "modifiers": [ [ "species_10332391", "catalyst" ] ], "additional_components": [ "ENSXETT00000020371" ] }, "reaction_10312850": { "compartment": "compartment_876", "id": "reaction_10312850", "reactome": "R-XTR-140761", "name": "sequestered tissue factor -> tissue factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312848" ], "products": [ "species_10312846" ], "modifiers": [], "additional_components": [ "ENSXETG00000030465", "ENSXETG00000030465" ] }, "reaction_10322381": { "compartment": "compartment_984", "id": "reaction_10322381", "reactome": "R-XTR-1297333", "name": "Association of Acrosin Heavy and Light Chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322369", "species_10322377" ], "products": [ "species_10322379" ], "modifiers": [], "additional_components": [ "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8R444", "ENSXETG00000036832", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8R444", "ENSXETG00000036832", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8R444", "ENSXETG00000036832" ] }, "reaction_10322392": { "compartment": "compartment_984", "id": "reaction_10322392", "reactome": "R-XTR-1297354", "name": "Acrosin Cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322389" ], "products": [ "species_10322369", "species_10322377" ], "modifiers": [ [ "species_10322389", "catalyst" ] ], "additional_components": [ "A0A6I8R444", "ENSXETG00000036832", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8R444", "ENSXETG00000036832", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8SN95", "ENSXETG00000034074", "A0A6I8R444", "ENSXETG00000036832", "A0A6I8R444", "ENSXETG00000036832", "A0A6I8RYQ2", "ENSXETG00000033999", "A0A6I8SN95", "ENSXETG00000034074" ] }, "reaction_10328392": { "compartment": "compartment_70101", "id": "reaction_10328392", "reactome": "R-XTR-3965450", "name": "DAAM1 recruits PFN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10315909", "species_10328315" ], "products": [ "species_10328390" ], "modifiers": [], "additional_components": [ "ENSXETG00000036913", "A0A6I8SJ25", "ENSXETG00000017030", "Q05AS8", "ENSXETG00000017212", "A0A6I8SJ25", "ENSXETG00000017030", "Q05AS8", "ENSXETG00000017212", "A0A6I8RDQ2", "ENSXETG00000036913" ] }, "reaction_10328309": { "compartment": "compartment_876", "id": "reaction_10328309", "reactome": "R-XTR-3858482", "name": "DVL is recruited to the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328305", "species_10328303" ], "products": [ "species_10328307" ], "modifiers": [], "additional_components": [ "Q05AS8", "ENSXETG00000017212", "B2GUT4", "ENSXETT00000042046", "Q5BL72", "ENSXETT00000027115", "B2GUT4", "ENSXETT00000042046", "Q5BL72", "ENSXETT00000027115", "Q05AS8", "ENSXETG00000017212" ] }, "reaction_10328295": { "compartment": "compartment_70101", "id": "reaction_10328295", "reactome": "R-XTR-3858475", "name": "ppDVL recruits RAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10328291", "species_10318239" ], "products": [ "species_10328293" ], "modifiers": [], "additional_components": [ "Q05AS8", "ENSXETG00000017212", "F7DEH8", "ENSXETT00000009928", "Q6GL60", "ENSXETT00000092508", "species_29438", "F7DEH8", "ENSXETT00000009928", "Q6GL60", "ENSXETT00000092508", "species_29438", "Q05AS8", "ENSXETG00000017212" ] }, "reaction_10316717": { "compartment": "compartment_70101", "id": "reaction_10316717", "reactome": "R-XTR-351863", "name": "Translocation of active caspase-8 to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316682" ], "products": [ "species_10316715" ], "modifiers": [], "additional_components": [ "A0A6I8Q0P2", "ENSXETG00000032748", "A0A6I8Q0P2", "ENSXETG00000032748" ] }, "reaction_10335361": { "compartment": "compartment_7660", "id": "reaction_10335361", "reactome": "R-XTR-8857692", "name": "RNA demethylases demethylate N6-methyladenosine RNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8857725", "species_113671", "species_111793" ], "products": [ "species_8857850", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10335358", "catalyst" ] ], "additional_components": [ "species_435347", "F6U6S7", "ENSXETT00000012796", "Q66JG8", "ENSXETT00000012702" ] }, "reaction_10337796": { "compartment": "compartment_7660", "id": "reaction_10337796", "reactome": "R-XTR-9624120", "name": "CEBPA binds CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311327", "species_10337788" ], "products": [ "species_10337794" ], "modifiers": [], "additional_components": [ "ENSXETT00000046130", "ENSXETG00000039574", "A0A6I8R9D5", "ENSXETG00000039574", "F6T0J1", "ENSXETT00000046130" ] }, "reaction_10337792": { "compartment": "compartment_7660", "id": "reaction_10337792", "reactome": "R-XTR-9624112", "name": "CEBPA binds CDK4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10337784", "species_10337788" ], "products": [ "species_10337790" ], "modifiers": [], "additional_components": [ "ENSXETG00000035239", "ENSXETG00000039574", "A0A6I8R9D5", "ENSXETG00000039574", "A0A6I8R6Z7", "ENSXETG00000035239" ] }, "reaction_10334445": { "compartment": "compartment_70101", "id": "reaction_10334445", "reactome": "R-XTR-6806613", "name": "Keratin tetramers bind to form unit length filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334433" ], "products": [ "species_10334437" ], "modifiers": [], "additional_components": [ "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390" ] }, "reaction_10334431": { "compartment": "compartment_70101", "id": "reaction_10334431", "reactome": "R-XTR-6805546", "name": "Keratin type I binds keratin type II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334213", "species_10334427" ], "products": [ "species_10334429" ], "modifiers": [], "additional_components": [ "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390" ] }, "reaction_10334443": { "compartment": "compartment_70101", "id": "reaction_10334443", "reactome": "R-XTR-6806610", "name": "Keratin filament formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334439" ], "products": [ "species_10334441" ], "modifiers": [], "additional_components": [ "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390" ] }, "reaction_10334449": { "compartment": "compartment_70101", "id": "reaction_10334449", "reactome": "R-XTR-6806629", "name": "Formation of tonofilament bundles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334441" ], "products": [ "species_10334447" ], "modifiers": [], "additional_components": [ "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390" ] }, "reaction_10334435": { "compartment": "compartment_70101", "id": "reaction_10334435", "reactome": "R-XTR-6805573", "name": "Keratin type I/type II heterodimers form tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10334429" ], "products": [ "species_10334433" ], "modifiers": [], "additional_components": [ "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390", "A0A6I8RI96", "ENSXETG00000038203", "A0A6I8S2K8", "ENSXETG00000040497", "A0A6I8PUX0", "ENSXETG00000040611", "A0A6I8R5I7", "ENSXETG00000040611", "A0A6I8QYX0", "ENSXETG00000039697", "F7AZB6", "ENSXETT00000027288", "A0A6I8S6R3", "ENSXETG00000029985", "A0A6I8R639", "ENSXETG00000040013", "Q6P864", "ENSXETG00000005611", "F6SZX5", "ENSXETT00000022390" ] }, "reaction_10331235": { "compartment": "compartment_876", "id": "reaction_10331235", "reactome": "R-XTR-5692408", "name": "NPR2 binds NPPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10331227", "species_10331231" ], "products": [ "species_10331233" ], "modifiers": [], "additional_components": [ "ENSXETG00000041083", "ENSXETG00000031971", "A0A6I8SDR4", "ENSXETG00000031971", "A0A6I8SMD0", "ENSXETG00000041083" ] }, "reaction_10329753": { "compartment": "compartment_70101", "id": "reaction_10329753", "reactome": "R-XTR-5578777", "name": "DMPK phosphorylates PLN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10318047" ], "products": [ "species_29370", "species_10318052" ], "modifiers": [ [ "species_10329750", "catalyst" ] ], "additional_components": [ "A0A6I8ST89", "ENSXETG00000036412", "A0A6I8ST89", "ENSXETG00000036412", "F6V346", "ENSXETT00000036273" ] }, "reaction_10329776": { "compartment": "compartment_70101", "id": "reaction_10329776", "reactome": "R-XTR-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10329773", "catalyst" ] ], "additional_components": [ "F6WH56", "ENSXETT00000048965", "F7AEN8", "ENSXETT00000009094" ] }, "reaction_10312747": { "compartment": "compartment_70101", "id": "reaction_10312747", "reactome": "R-XTR-114553", "name": "Activation of conventional Protein Kinase C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_10312735", "species_74016" ], "products": [ "species_10312745" ], "modifiers": [ [ "species_114519", "catalyst" ] ], "additional_components": [ "ENSXETG00000017294", "species_114519", "species_33625", "species_74112", "A8KBH6", "ENSXETG00000017294" ] }, "reaction_10318808": { "compartment": "compartment_876", "id": "reaction_10318808", "reactome": "R-XTR-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318758" ], "products": [ "species_10318806" ], "modifiers": [], "additional_components": [ "A0A6I8QDT0", "ENSXETG00000039678", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8S6I0", "ENSXETG00000027692", "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942", "A0A6I8QL92", "ENSXETG00000039008", "F6SYS3", "ENSXETT00000046350", "A0A6I8S033", "ENSXETG00000009423", "A0A6I8PY35", "ENSXETG00000033269", "F7B6V1", "ENSXETT00000038623", "A0A6I8Q251", "ENSXETG00000030791", "F7D5C5", "ENSXETT00000001620", "F6TMK5", "ENSXETT00000046700", "F7CZB7", "ENSXETT00000006287", "A0A6I8PVG7", "ENSXETG00000031284", "A0A6I8Q0D7", "ENSXETG00000032630", "F7C1U1", "ENSXETT00000043296", "Q5BKJ7", "ENSXETT00000050639", "A0A6I8SC83", "ENSXETG00000038196", "F6SX40", "ENSXETT00000046545", "A0A6I8STH4", "ENSXETG00000035410", "F6YIE1", "ENSXETT00000016028", "Q6P326", "ENSXETG00000021646", "Q66JG0", "ENSXETG00000008500", "F7CWY4", "ENSXETT00000011877", "F7CZB7", "ENSXETT00000006287", "A0A6I8S6I0", "ENSXETG00000027692", "A0A6I8S564", "ENSXETG00000009402", "A0A6I8QI46", "ENSXETG00000007942", "Q66JG0", "ENSXETG00000008500", "Q5BKJ7", "ENSXETT00000050639", "F7B6V1", "ENSXETT00000038623", "A0A6I8PY35", "ENSXETG00000033269", "A0A6I8QDT0", "ENSXETG00000039678", "A0A6I8SHN1", "ENSXETG00000035535", "A0A6I8S033", "ENSXETG00000009423", "F7D5C5", "ENSXETT00000001620", "A0A6I8STH4", "ENSXETG00000035410", "A0A6I8Q0D7", "ENSXETG00000032630", "F6SYS3", "ENSXETT00000046350", "A0A6I8QL92", "ENSXETG00000039008", "F7CWY4", "ENSXETT00000011877", "F6YIE1", "ENSXETT00000016028", "Q6P326", "ENSXETG00000021646", "F6TMK5", "ENSXETT00000046700", "F7C1U1", "ENSXETT00000043296", "A0A6I8SC83", "ENSXETG00000038196", "A0A6I8Q251", "ENSXETG00000030791", "A0A6I8PVG7", "ENSXETG00000031284", "F6SX40", "ENSXETT00000046545" ] }, "reaction_10318868": { "compartment": "compartment_876", "id": "reaction_10318868", "reactome": "R-XTR-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318842" ], "products": [ "species_10318866" ], "modifiers": [], "additional_components": [ "species_29438", "species_29370", "B0BLS9", "ENSXETT00000049183", "species_109496", "Q28F45", "ENSXETT00000055303", "species_113593", "Q28HY7", "ENSXETG00000000595", "species_29372", "A0A6I8RL39", "ENSXETG00000006887", "A0A6I8SSC0", "ENSXETG00000036712", "species_74112", "species_114523", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350", "A0A6I8QL92", "ENSXETG00000039008", "species_29420", "species_159450", "species_74112", "species_29438", "species_29370", "species_159450", "species_109496", "species_113593", "A0A6I8RL39", "ENSXETG00000006887", "A0A6I8SSC0", "ENSXETG00000036712", "B0BLS9", "ENSXETT00000049183", "Q28HY7", "ENSXETG00000000595", "species_114523", "Q28F45", "ENSXETT00000055303", "species_29372", "species_29420", "A0A6I8QL92", "ENSXETG00000039008", "A0A6I8S033", "ENSXETG00000009423", "F6SYS3", "ENSXETT00000046350" ] }, "reaction_10318948": { "compartment": "compartment_70101", "id": "reaction_10318948", "reactome": "R-XTR-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318936" ], "products": [ "species_10318946" ], "modifiers": [], "additional_components": [ "Q6DIF4", "ENSXETG00000000629", "Q28IX8", "ENSXETG00000019288", "A0A6I8RS05", "ENSXETG00000036422", "Q0IIW3", "ENSXETT00000015994", "Q6DIF4", "ENSXETG00000000629", "Q0IIW3", "ENSXETT00000015994", "Q28IX8", "ENSXETG00000019288", "A0A6I8RS05", "ENSXETG00000036422" ] }, "reaction_10318918": { "compartment": "compartment_984", "id": "reaction_10318918", "reactome": "R-XTR-482770", "name": "Release of platelet secretory granule components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318910" ], "products": [ "species_10318916" ], "modifiers": [], "additional_components": [ "F7E728", "ENSXETG00000020755", "A0A6I8PU04", "ENSXETG00000033423", "Q501K5", "ENSXETG00000011814", "A0A6I8PU04", "ENSXETG00000033423", "Q501K5", "ENSXETG00000011814", "F7E728", "ENSXETG00000020755" ] }, "reaction_10316707": { "compartment": "compartment_161320", "id": "reaction_10316707", "reactome": "R-XTR-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10316703" ], "products": [ "species_10316705" ], "modifiers": [], "additional_components": [ "ENSXETT00000041328", "ENSXETT00000041328" ] }, "reaction_10318882": { "compartment": "compartment_876", "id": "reaction_10318882", "reactome": "R-XTR-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318876" ], "products": [ "species_10318880" ], "modifiers": [], "additional_components": [ "A0A6I8SL99", "ENSXETG00000003366", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8SL99", "ENSXETG00000003366", "A0A6I8SFE9", "ENSXETG00000039556" ] }, "reaction_10318898": { "compartment": "compartment_876", "id": "reaction_10318898", "reactome": "R-XTR-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318892" ], "products": [ "species_10318896" ], "modifiers": [], "additional_components": [ "A0A6I8Q083", "ENSXETG00000031004", "A0A6I8S279", "ENSXETG00000037724", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8Q083", "ENSXETG00000031004", "A0A6I8SFE9", "ENSXETG00000039556", "A0A6I8S279", "ENSXETG00000037724" ] }, "reaction_10318249": { "compartment": "compartment_70101", "id": "reaction_10318249", "reactome": "R-XTR-442273", "name": "VAV1 is a GEF for Rho/Rac family GTPases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10318237" ], "products": [ "species_29420", "species_10318239" ], "modifiers": [ [ "species_10318242", "catalyst" ], [ "species_10318247", "catalyst" ], [ "species_10318245", "inhibitor" ] ], "additional_components": [ "F7DEH8", "ENSXETT00000009928", "Q6GL60", "ENSXETT00000092508", "species_29420", "F7DEH8", "ENSXETT00000009928", "Q6GL60", "ENSXETT00000092508", "species_29438", "ENSXETT00000043225", "species_179838", "L7N3Q8", "ENSXETT00000043225", "species_179856", "L7N3Q8", "ENSXETT00000043225" ] }, "reaction_10318123": { "compartment": "compartment_876", "id": "reaction_10318123", "reactome": "R-XTR-429497", "name": "SLP-76 stimulates PLC gamma 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10318121" ], "products": [ "species_10312756" ], "modifiers": [], "additional_components": [ "ENSXETG00000003578", "ENSXETG00000003578" ] }, "reaction_10312759": { "compartment": "compartment_70101", "id": "reaction_10312759", "reactome": "R-XTR-114689", "name": "PLC gamma 2-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10312756", "catalyst" ] ], "additional_components": [ "ENSXETG00000003578" ] }, "reaction_10322394": { "compartment": "compartment_876", "id": "reaction_10322394", "reactome": "R-XTR-1297444", "name": "Binding of cAMP to HCN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10322341", "species_30389" ], "products": [ "species_10322343" ], "modifiers": [], "additional_components": [ "A0A6I8SMA9", "ENSXETG00000017714", "A0A6I8RXX5", "ENSXETG00000031566", "species_30389", "A0A6I8SMA9", "ENSXETG00000017714", "A0A6I8RXX5", "ENSXETG00000031566" ] }, "reaction_10322346": { "compartment": "compartment_876", "id": "reaction_10322346", "reactome": "R-XTR-1296043", "name": "Activation of HCN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10322343", "catalyst" ] ], "additional_components": [ "species_30389", "A0A6I8SMA9", "ENSXETG00000017714", "A0A6I8RXX5", "ENSXETG00000031566" ] }, "reaction_10317036": { "compartment": "compartment_204883", "id": "reaction_10317036", "reactome": "R-XTR-375342", "name": "Connexin 36 mediated neuronal gap junction communication", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_29804" ], "modifiers": [ [ "species_10317033", "catalyst" ] ], "additional_components": [ "A0A6I8RRX1", "ENSXETG00000038711" ] }, "reaction_10311663": { "compartment": "compartment_876", "id": "reaction_10311663", "reactome": "R-XTR-71050", "name": "Trimerization of the FASL:FAS receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311659" ], "products": [ "species_10311661" ], "modifiers": [], "additional_components": [ "A0A6I8PTW1", "ENSXETG00000031916", "A0A6I8QWZ8", "ENSXETG00000041356", "A0A6I8PTW1", "ENSXETG00000031916", "A0A6I8QWZ8", "ENSXETG00000041356" ] }, "reaction_10312086": { "compartment": "compartment_876", "id": "reaction_10312086", "reactome": "R-XTR-75244", "name": "FASL binds FAS Receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10311653", "species_10311657" ], "products": [ "species_10311659" ], "modifiers": [], "additional_components": [ "ENSXETG00000041356", "ENSXETG00000031916", "A0A6I8PTW1", "ENSXETG00000031916", "A0A6I8QWZ8", "ENSXETG00000041356" ] }, "reaction_10312879": { "compartment": "compartment_984", "id": "reaction_10312879", "reactome": "R-XTR-140847", "name": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10312839", "species_74112" ], "products": [ "species_10312833", "species_10312877" ], "modifiers": [], "additional_components": [ "F6YIE1", "ENSXETT00000016028", "A0A6I8PQF3", "ENSXETG00000031728", "ENSXETG00000031728", "species_74112", "F6YIE1", "ENSXETT00000016028" ] }, "reaction_10326879": { "compartment": "compartment_876", "id": "reaction_10326879", "reactome": "R-XTR-2534378", "name": "Hv1 Mediated H+ Permeability", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1132304" ], "products": [ "species_351626" ], "modifiers": [ [ "species_10326876", "catalyst" ] ], "additional_components": [ "Q5M8L8", "ENSXETT00000045238" ] }, "reaction_10326870": { "compartment": "compartment_876", "id": "reaction_10326870", "reactome": "R-XTR-2534346", "name": "SPAM1 Binds Hyaluronic Acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10326866", "species_1297302" ], "products": [ "species_10326868" ], "modifiers": [], "additional_components": [ "ENSXETG00000033261", "species_1297302", "A0A6I8PVK0", "ENSXETG00000033261" ] }, "reaction_10330885": { "compartment": "compartment_5460", "id": "reaction_10330885", "reactome": "R-XTR-5688289", "name": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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